Cheap flights from Knoxville to Panama City from $395
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 11/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Fly from
Fly to
Route
Depart
Return
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Tue 12/8
6:20 am-8:02 pm
1 stop13h 42m
Panama City Tocumen Intl
Wed 12/16
8:55 am-9:57 pm
1 stop13h 02m
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 2/24
7:00 am-5:12 pm
1 stop10h 12m
Panama City Tocumen Intl
Tue 3/2
4:41 pm-11:01 am
1 stop18h 20m
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Tue 12/8
7:45 pm-8:02 pm
2 stops24h 17m
Panama City Tocumen Intl
Wed 12/16
11:35 am-11:59 pm
2 stops12h 24m
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 2/24
12:00 pm-7:38 pm
1 stop7h 38m
Panama City Tocumen Intl
Tue 3/2
8:55 am-11:36 am
3 stops26h 41m
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Tue 12/8
7:05 am-5:12 pm
1 stop10h 07m
Panama City Tocumen Intl
Wed 12/16
8:55 am-11:59 pm
2 stops15h 04m
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 2/24
7:35 pm-5:12 pm
2 stops21h 37m
Panama City Tocumen Intl
Tue 3/2
11:35 am-11:36 am
3 stops24h 01m
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 2/24
5:45 pm-2:45 pm
2 stops21h 00m
Panama City Tocumen Intl
Tue 3/2
4:41 pm-11:01 am
1 stop18h 20m
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Thu 11/19
11:20 am-8:02 pm
1 stop8h 42m
Panama City Tocumen Intl
Thu 11/26
8:55 am-9:57 pm
1 stop13h 02m
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Thu 11/19
5:45 am-7:38 pm
2 stops13h 53m
Panama City Tocumen Intl
Thu 11/26
8:55 am-9:57 pm
1 stop13h 02m
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Thu 11/19
6:45 am-8:02 pm
2 stops13h 17m
Panama City Tocumen Intl
Thu 11/26
10:00 am-2:48 pm
2 stops28h 48m
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How to get the cheapest flight ticket from Knoxville to Panama City
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
When to book flights from Knoxville to Panama City
Cheap Knoxville to Panama City (TYS to PTY) flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama City
Frequently asked questions about flying from Knoxville to Panama City
How far is Knoxville McGhee Tyson to Panama City Tocumen Intl by plane?
A flight from Knoxville McGhee Tyson to Panama City Tocumen Intl will travel around 1883.0 mi. Typically, this will take 8h 42m by plane in normal conditions.
When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?
Prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?
There is 1 operator available for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport as of October 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport.
What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?
The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Knoxville to Panama City?
Based on momondo bookings for flights between Knoxville and Panama City, the leading airline is Delta, making up 100% of the total bookings.
Best airlines flying from Knoxville to Panama City
Compare and see reviews for airlines that fly from Knoxville to Panama City with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $586 | Free Cancellation | Rating 7.8 8,646 reviews |
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Yes. momondo enables you to select and highlight flights to Panama City from Knoxville with this policy.
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