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Cheap flights from Knoxville to Panama City from $407

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 8/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Knoxville to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:57 pm - 2:14 pm
TYS
-
PTY
21h 17m
2 stops
United Airlines Logo
10:00 am - 9:30 pm
PTY
-
TYS
10h 30m
1 stop
$527United Airlines
Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
10:55 pm - 4:59 pm
PTY
-
TYS
17h 04m
2 stops
$531United Airlines
Mon, Aug 17 - Thu, Aug 20
United Airlines Logo
5:57 pm - 2:14 pm
TYS
-
PTY
21h 17m
2 stops
United Airlines Logo
3:30 pm - 6:05 pm
PTY
-
TYS
25h 35m
1 stop
$536United Airlines
Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
3:25 pm - 6:37 pm
TYS
-
PTY
28h 12m
1 stop
United Airlines Logo
3:30 pm - 6:05 pm
PTY
-
TYS
25h 35m
1 stop
$546United Airlines
Sun, Aug 23 - Wed, Aug 26
United Airlines Logo
7:00 am - 7:31 pm
TYS
-
PTY
13h 31m
2 stops
United Airlines Logo
7:55 am - 6:11 pm
PTY
-
TYS
9h 16m
1 stop
$547United Airlines
Tue, May 12 - Tue, May 19
United Airlines Logo
7:18 pm - 2:14 pm
TYS
-
PTY
19h 56m
2 stops
United Airlines Logo
9:45 am - 10:49 am
PTY
-
TYS
24h 04m
2 stops
$551United Airlines
Tue, May 12 - Tue, May 19
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
10:00 am - 9:30 pm
PTY
-
TYS
10h 30m
1 stop
$557United Airlines
Sun, Aug 23 - Wed, Aug 26
American Airlines Logo
5:13 pm - 2:20 pm
TYS
-
PTY
22h 07m
2 stops
American Airlines Logo
3:20 pm - 10:30 am
PTY
-
TYS
18h 10m
2 stops
$561American Airlines
Sat, Aug 8 - Fri, Aug 14
American Airlines Logo
7:59 pm - 12:14 pm
TYS
-
PTY
17h 15m
2 stops
American Airlines Logo
1:14 pm - 1:10 pm
PTY
-
TYS
22h 56m
2 stops
$566American Airlines
Thu, May 28 - Sun, May 31
American Airlines Logo
7:34 pm - 12:14 pm
TYS
-
PTY
17h 40m
1 stop
American Airlines Logo
1:14 pm - 11:59 pm
PTY
-
TYS
9h 45m
1 stop
$573American Airlines
Thu, May 28 - Sun, May 31

American Airlines flights from Knoxville to Panama City

Our best American Airlines deals on Knoxville to Panama City flight tickets
American Airlines
Aug 8
TYS5:13 pmKnoxville McGhee Tyson
22h 07m
2 stops
PTY2:20 pmPanama City Tocumen Intl
Aug 14
PTY3:20 pmPanama City Tocumen Intl
18h 10m
2 stops
TYS10:30 amKnoxville McGhee Tyson
$561
American Airlines
May 28
TYS7:59 pmKnoxville McGhee Tyson
17h 15m
2 stops
PTY12:14 pmPanama City Tocumen Intl
May 31
PTY1:14 pmPanama City Tocumen Intl
22h 56m
2 stops
TYS1:10 pmKnoxville McGhee Tyson
$566
American Airlines
May 28
TYS7:34 pmKnoxville McGhee Tyson
17h 40m
1 stop
PTY12:14 pmPanama City Tocumen Intl
May 31
PTY1:14 pmPanama City Tocumen Intl
9h 45m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$573

GOL flights from Knoxville to Panama City

Our best GOL deals on Knoxville to Panama City flight tickets
GOL
Jul 10
TYS6:00 amKnoxville McGhee Tyson
7h 14m
1 stop
PTY12:14 pmPanama City Tocumen Intl
Jul 19
PTY1:14 pmPanama City Tocumen Intl
9h 45m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$1,355
GOL
Jul 10
TYS8:05 pmKnoxville McGhee Tyson
17h 09m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Jul 19
PTY1:14 pmPanama City Tocumen Intl
9h 45m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$1,386
GOL
Jul 10
TYS8:05 pmKnoxville McGhee Tyson
17h 09m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Jul 19
PTY1:14 pmPanama City Tocumen Intl
20h 24m
2 stops
TYS10:38 amKnoxville McGhee Tyson
$1,422

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 8/23

5:57 pm-2:14 pm

2 stops21h 17m

Panama City Tocumen Intl

Wed 8/26

10:00 am-9:30 pm

1 stop10h 30m

$527

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 8/17

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Thu 8/20

10:55 pm-4:59 pm

2 stops17h 04m

$531

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 8/23

5:57 pm-2:14 pm

2 stops21h 17m

Panama City Tocumen Intl

Wed 8/26

3:30 pm-6:05 pm

1 stop25h 35m

$536

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 8/23

3:25 pm-6:37 pm

1 stop28h 12m

Panama City Tocumen Intl

Wed 8/26

3:30 pm-6:05 pm

1 stop25h 35m

$546

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 5/12

7:00 am-7:31 pm

2 stops13h 31m

Panama City Tocumen Intl

Tue 5/19

7:55 am-6:11 pm

1 stop9h 16m

$547

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 5/12

7:18 pm-2:14 pm

2 stops19h 56m

Panama City Tocumen Intl

Tue 5/19

9:45 am-10:49 am

2 stops24h 04m

$551
Quickest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 8/23

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Wed 8/26

10:00 am-9:30 pm

1 stop10h 30m

$557

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 8/8

5:13 pm-2:20 pm

2 stops22h 07m

Panama City Tocumen Intl

Fri 8/14

3:20 pm-10:30 am

2 stops18h 10m

$561

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 5/28

7:59 pm-12:14 pm

2 stops17h 15m

Panama City Tocumen Intl

Sun 5/31

1:14 pm-1:10 pm

2 stops22h 56m

$566

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 5/28

7:34 pm-12:14 pm

1 stop17h 40m

Panama City Tocumen Intl

Sun 5/31

1:14 pm-11:59 pm

1 stop9h 45m

$573

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Knoxville to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Panama City?

What is the cheapest month to fly to Panama City?

In general, September is the cheapest month to fly from Knoxville to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $471. If you’re not able to fly to Panama City in September, then April is your next best option. Flight prices from Knoxville to Panama City during April average around $496.

When to book flights from Knoxville to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Panama City (TYS to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama City

Fastest flight time

7h 57m

Direct flights

None
The fastest flight from Knoxville to Panama City takes 7h 57m
There are no direct flights from Knoxville to Panama City. There are no popular flight routes from Knoxville to Panama City.
Search flight deals

  • How far is Knoxville McGhee Tyson to Panama City Tocumen Intl by plane?

    A flight from Knoxville McGhee Tyson to Panama City Tocumen Intl will travel around 1883.0 mi. Typically, this will take 7h 57m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Knoxville to Panama City?

Best airlines flying from Knoxville to Panama City

Compare and see reviews for airlines that fly from Knoxville to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $261Free CancellationRating
7.4
9,514 reviews
Search United Airlines flights
American AirlinesPriceFrom $475Free CancellationRating
7.1
11,530 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Panama City?

Once all potential Knoxville to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

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