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Cheap flights from Knoxville to Panama City from $456

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 4/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
9:00 am - 4:12 pm
TYS
-
PTY
8h 12m1 stop
United Airlines Logo
7:55 am - 11:41 pm
PTY
-
TYS
14h 46m1 stop
$456United Airlines
Sat, Apr 18 - Wed, Apr 22
American Airlines Logo
5:14 pm - 1:27 pm
TYS
-
PTY
20h 13m2 stops
American Airlines Logo
4:50 pm - 11:31 am
PTY
-
TYS
18h 41m2 stops
$500American Airlines
Sun, Jan 25 - Fri, Jan 30
United Airlines Logo
9:05 am - 2:45 pm
TYS
-
PTY
29h 40m1 stop
United Airlines Logo
8:55 am - 6:05 pm
PTY
-
TYS
9h 10m1 stop
$505United Airlines
Sun, Jan 25 - Fri, Jan 30
American Airlines Logo
5:40 pm - 1:53 pm
TYS
-
PTY
20h 13m2 stops
American Airlines Logo
4:50 pm - 11:34 am
PTY
-
TYS
18h 44m2 stops
$545American Airlines
Sun, Jan 4 - Sun, Jan 18
American Airlines Logo
6:00 am - 3:52 pm
TYS
-
PTY
9h 52m2 stops
American Airlines Logo
5:00 pm - 11:03 am
PTY
-
TYS
18h 03m2 stops
$560American Airlines
Sat, Jan 10 - Sat, Jan 17
American Airlines Logo
5:40 pm - 1:53 pm
TYS
-
PTY
20h 13m2 stops
American Airlines Logo
4:50 pm - 10:49 am
PTY
-
TYS
17h 59m2 stops
$595American Airlines
Sun, Jan 4 - Sun, Jan 18
American Airlines Logo
5:36 pm - 3:38 pm
TYS
-
PTY
22h 02m1 stop
American Airlines Logo
5:00 pm - 11:03 am
PTY
-
TYS
18h 03m2 stops
$602American Airlines
Sat, Jan 10 - Sat, Jan 17
United Airlines Logo
9:05 am - 5:07 pm
TYS
-
PTY
8h 02m1 stop
United Airlines Logo
4:41 pm - 6:10 pm
PTY
-
TYS
25h 29m1 stop
$614United Airlines
Thu, Feb 5 - Thu, Feb 12
United Airlines Logo
11:40 am - 7:38 pm
TYS
-
PTY
7h 58m1 stop
United Airlines Logo
4:41 pm - 6:05 pm
PTY
-
TYS
25h 24m1 stop
$678United Airlines
Sat, Jan 10 - Sat, Jan 17
United Airlines Logo
11:58 am - 2:45 pm
TYS
-
PTY
26h 47m1 stop
United Airlines Logo
4:41 pm - 1:50 pm
PTY
-
TYS
21h 09m1 stop
$698United Airlines
Sun, Jan 4 - Sun, Jan 18

United Airlines flights from Knoxville to Panama City

Our best United Airlines deals on Knoxville to Panama City flight tickets
United Airlines
Apr 18
TYS9:00 amKnoxville McGhee Tyson
8h 12m
1 stop
PTY4:12 pmPanama City Tocumen Intl
Apr 22
PTY7:55 amPanama City Tocumen Intl
14h 46m
1 stop
TYS11:41 pmKnoxville McGhee Tyson
$456
Find similar
United Airlines
Jan 25
TYS9:05 amKnoxville McGhee Tyson
29h 40m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Jan 30
PTY8:55 amPanama City Tocumen Intl
9h 10m
1 stop
TYS6:05 pmKnoxville McGhee Tyson
$505
Find similar
United Airlines
Feb 5
TYS9:05 amKnoxville McGhee Tyson
8h 02m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Feb 12
PTY4:41 pmPanama City Tocumen Intl
25h 29m
1 stop
TYS6:10 pmKnoxville McGhee Tyson
$614
Find similar

American Airlines flights from Knoxville to Panama City

Our best American Airlines deals on Knoxville to Panama City flight tickets
American Airlines
Jan 25
TYS5:14 pmKnoxville McGhee Tyson
20h 13m
2 stops
PTY1:27 pmPanama City Tocumen Intl
Jan 30
PTY4:50 pmPanama City Tocumen Intl
18h 41m
2 stops
TYS11:31 amKnoxville McGhee Tyson
$500
Find similar
American Airlines
Jan 4
TYS5:40 pmKnoxville McGhee Tyson
20h 13m
2 stops
PTY1:53 pmPanama City Tocumen Intl
Jan 18
PTY4:50 pmPanama City Tocumen Intl
18h 44m
2 stops
TYS11:34 amKnoxville McGhee Tyson
$545
Find similar
American Airlines
Jan 10
TYS6:00 amKnoxville McGhee Tyson
9h 52m
2 stops
PTY3:52 pmPanama City Tocumen Intl
Jan 17
PTY5:00 pmPanama City Tocumen Intl
18h 03m
2 stops
TYS11:03 amKnoxville McGhee Tyson
$560
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 4/18

9:00 am-4:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Wed 4/22

7:55 am-11:41 pm

1 stop14h 46m

$456

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/25

5:14 pm-1:27 pm

2 stops20h 13m

Panama City Tocumen Intl

Fri 1/30

4:50 pm-11:31 am

2 stops18h 41m

$500

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/25

9:05 am-2:45 pm

1 stop29h 40m

Panama City Tocumen Intl

Fri 1/30

8:55 am-6:05 pm

1 stop9h 10m

$505

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

5:40 pm-1:53 pm

2 stops20h 13m

Panama City Tocumen Intl

Sun 1/18

4:50 pm-11:34 am

2 stops18h 44m

$545

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 1/10

6:00 am-3:52 pm

2 stops9h 52m

Panama City Tocumen Intl

Sat 1/17

5:00 pm-11:03 am

2 stops18h 03m

$560

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

5:40 pm-1:53 pm

2 stops20h 13m

Panama City Tocumen Intl

Sun 1/18

4:50 pm-10:49 am

2 stops17h 59m

$595

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 1/10

5:36 pm-3:38 pm

1 stop22h 02m

Panama City Tocumen Intl

Sat 1/17

5:00 pm-11:03 am

2 stops18h 03m

$602

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 2/5

9:05 am-5:07 pm

1 stop8h 02m

Panama City Tocumen Intl

Thu 2/12

4:41 pm-6:10 pm

1 stop25h 29m

$614

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 1/10

11:40 am-7:38 pm

1 stop7h 58m

Panama City Tocumen Intl

Sat 1/17

4:41 pm-6:05 pm

1 stop25h 24m

$678

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 1/4

11:58 am-2:45 pm

1 stop26h 47m

Panama City Tocumen Intl

Sun 1/18

4:41 pm-1:50 pm

1 stop21h 09m

$698

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from Knoxville to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Panama City?

What is the cheapest month to fly to Panama City?

In general, September is the cheapest month to fly from Knoxville to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $471. If you’re not able to fly to Panama City in September, then February is your next best option. Flight prices from Knoxville to Panama City during February average around $497.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Friday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $517. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $818. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

When to book flights from Knoxville to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Panama City (TYS to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama City

Fastest flight time

7h 45m

Direct flights

None
The fastest flight from Knoxville to Panama City takes 7h 45m
There are no direct flights from Knoxville to Panama City. There are no popular flight routes from Knoxville to Panama City.
Search flight deals

  • How far is Knoxville McGhee Tyson to Panama City Tocumen Intl by plane?

    A flight from Knoxville McGhee Tyson to Panama City Tocumen Intl will travel around 1883.0 mi. Typically, this will take 7h 45m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Knoxville to Panama City?

Best airlines flying from Knoxville to Panama City

Compare and see reviews for airlines that fly from Knoxville to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $387Free CancellationRating
7.4
9,105 reviews
Search United Airlines flights
American AirlinesPriceFrom $461Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Panama City?

Once all potential Knoxville to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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