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Cheap flights from Knoxville to Panama City from $401

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

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Delta Logo
5:30 am - 12:55 pmTYS-PTY
8h 25m1 stop
Delta Logo
2:20 pm - 11:44 pmPTY-TYS
8h 24m1 stop
$476Delta
Find Deal
lun., abr. 6 - mar., abr. 7
American Airlines Logo
4:28 pm - 1:53 pmTYS-PTY
21h 25m2 stops
American Airlines Logo
2:27 pm - 11:34 amPTY-TYS
21h 07m2 stops
$485American Airlines
Find Deal
dom., ene. 4 - dom., ene. 18
Delta Logo
5:30 am - 12:55 pmTYS-PTY
8h 25m1 stop
Delta Logo
2:20 pm - 11:44 pmPTY-TYS
8h 24m1 stop
$501Delta
Find Deal
lun., abr. 6 - mar., abr. 7
American Airlines Logo
4:12 pm - 1:53 pmTYS-PTY
21h 41m2 stops
American Airlines Logo
2:53 pm - 8:56 amPTY-TYS
18h 03m2 stops
$550American Airlines
Find Deal
jue., dic. 18 - jue., dic. 25
American Airlines Logo
4:12 pm - 1:53 pmTYS-PTY
21h 41m2 stops
American Airlines Logo
2:53 pm - 10:16 pmPTY-TYS
7h 23m1 stop
$620American Airlines
Find Deal
jue., dic. 18 - jue., dic. 25
United Airlines Logo
7:00 am - 7:38 pmTYS-PTY
12h 38m1 stop
United Airlines Logo
4:41 pm - 7:50 pmPTY-TYS
27h 09m1 stop
$635United Airlines
Find Deal
dom., ene. 4 - dom., ene. 18
American Airlines Logo
7:04 am - 12:10 pmTYS-PTY
6h 06m1 stop
American Airlines Logo
1:55 pm - 10:46 amPTY-TYS
19h 51m2 stops
$645American Airlines
Find Deal
lun., abr. 6 - mar., abr. 7
American Airlines Logo
5:08 pm - 1:53 pmTYS-PTY
20h 45m2 stops
American Airlines Logo
4:55 pm - 12:38 amPTY-TYS
7h 43m1 stop
$690American Airlines
Find Deal
lun., dic. 22 - lun., dic. 29
Multiple Airlines Logo
2:56 pm - 4:55 pmTYS-PTY
25h 59m3 stops
Multiple Airlines Logo
2:55 am - 8:33 amPTY-TYS
29h 38m3 stops
$924Multiple Airlines
Find Deal
jue., dic. 18 - mié., dic. 24
Multiple Airlines Logo
2:56 pm - 4:55 pmTYS-PTY
25h 59m3 stops
Multiple Airlines Logo
11:25 am - 11:55 amPTY-TYS
24h 30m3 stops
$933Multiple Airlines
Find Deal
jue., dic. 18 - jue., dic. 25

Delta flights from Knoxville to Panama City

Our best Delta deals on Knoxville to Panama City flight tickets
Delta
Apr 6
TYS5:30 amKnoxville McGhee Tyson
8h 25m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Apr 7
PTY2:20 pmPanama City Tocumen Intl
8h 24m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
$476
Find similar
Delta
Apr 6
TYS5:30 amKnoxville McGhee Tyson
8h 25m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Apr 7
PTY2:20 pmPanama City Tocumen Intl
8h 24m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
$501
Find similar
Delta
Nov 22
TYS8:45 amKnoxville McGhee Tyson
11h 14m
1 stop
PTY7:59 pmPanama City Tocumen Intl
Nov 29
PTY8:05 amPanama City Tocumen Intl
10h 57m
1 stop
TYS7:02 pmKnoxville McGhee Tyson
$807
Find similar

American Airlines flights from Knoxville to Panama City

Our best American Airlines deals on Knoxville to Panama City flight tickets
American Airlines
Jan 4
TYS4:28 pmKnoxville McGhee Tyson
21h 25m
2 stops
PTY1:53 pmPanama City Tocumen Intl
Jan 18
PTY2:27 pmPanama City Tocumen Intl
21h 07m
2 stops
TYS11:34 amKnoxville McGhee Tyson
$485
Find similar
American Airlines
Dec 18
TYS4:12 pmKnoxville McGhee Tyson
21h 41m
2 stops
PTY1:53 pmPanama City Tocumen Intl
Dec 25
PTY2:53 pmPanama City Tocumen Intl
18h 03m
2 stops
TYS8:56 amKnoxville McGhee Tyson
$550
Find similar
American Airlines
Dec 18
TYS4:12 pmKnoxville McGhee Tyson
21h 41m
2 stops
PTY1:53 pmPanama City Tocumen Intl
Dec 25
PTY2:53 pmPanama City Tocumen Intl
7h 23m
1 stop
TYS10:16 pmKnoxville McGhee Tyson
$620
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated noviembre 3, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

lun. 4/6

5:30 am-12:55 pm

1 stop8h 25m

Panama City Tocumen Intl

mar. 4/7

2:20 pm-11:44 pm

1 stop8h 24m

$476

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

dom. 1/4

4:28 pm-1:53 pm

2 stops21h 25m

Panama City Tocumen Intl

dom. 1/18

2:27 pm-11:34 am

2 stops21h 07m

$485

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

lun. 4/6

5:30 am-12:55 pm

1 stop8h 25m

Panama City Tocumen Intl

mar. 4/7

2:20 pm-11:44 pm

1 stop8h 24m

$501

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

jue. 12/18

4:12 pm-1:53 pm

2 stops21h 41m

Panama City Tocumen Intl

jue. 12/25

2:53 pm-8:56 am

2 stops18h 03m

$550

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

jue. 12/18

4:12 pm-1:53 pm

2 stops21h 41m

Panama City Tocumen Intl

jue. 12/25

2:53 pm-10:16 pm

1 stop7h 23m

$620

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

dom. 1/4

7:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

dom. 1/18

4:41 pm-7:50 pm

1 stop27h 09m

$635

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

lun. 4/6

7:04 am-12:10 pm

1 stop6h 06m

Panama City Tocumen Intl

mar. 4/7

1:55 pm-10:46 am

2 stops19h 51m

$645

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

lun. 12/22

5:08 pm-1:53 pm

2 stops20h 45m

Panama City Tocumen Intl

lun. 12/29

4:55 pm-12:38 am

1 stop7h 43m

$690

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

jue. 12/18

2:56 pm-4:55 pm

3 stops25h 59m

Panama City Tocumen Intl

mié. 12/24

2:55 am-8:33 am

3 stops29h 38m

$924

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

jue. 12/18

2:56 pm-4:55 pm

3 stops25h 59m

Panama City Tocumen Intl

jue. 12/25

11:25 am-11:55 am

3 stops24h 30m

$933

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Knoxville to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Panama City?

What is the cheapest month to fly to Panama City?

In general, September is the cheapest month to fly from Knoxville to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $471. If you’re not able to fly to Panama City in September, then February is your next best option. Flight prices from Knoxville to Panama City during February average around $497.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Friday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $517. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $818. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

When to book flights from Knoxville to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Panama City (TYS to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama City

Direct flights

None
There are no direct flights from Knoxville to Panama City. There are no popular flight routes from Knoxville to Panama City.
Search flight deals

  • How far is Knoxville McGhee Tyson to Panama City Tocumen Intl by plane?

    A flight from Knoxville McGhee Tyson to Panama City Tocumen Intl will travel around 1883.0 mi. Typically, this will take 6h 06m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Knoxville to Panama City?

Best airlines flying from Knoxville to Panama City

Compare and see reviews for airlines that fly from Knoxville to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $387Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights
American AirlinesPriceFrom $440Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Panama City?

Once all potential Knoxville to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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