What airlines fly to Panama City?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Panama City from Knoxville according to our data. Delta is the first choice among our users, with 65% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 3 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

Prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport as of August 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport.

What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$653 Cheap Flights from Knoxville to Panama City in 2026

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7:15 am - 2:14 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

7h 59m1 stop Houston George Bush Intcntl

9:45 am - 8:45 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

10h 00m1 stop Newark

$653United Airlines

Wed, Oct 7 - Wed, Oct 14

6:00 am - 7:31 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

14h 31m2 stops Chicago O'Hare Intl Newark

3:30 pm - 1:14 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

20h 44m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$657United Airlines

Wed, Oct 7 - Wed, Oct 14

5:45 am - 7:31 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

14h 46m2 stops Washington, D.C. Dulles Intl Newark

10:00 am - 9:55 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

10h 55m1 stop Houston George Bush Intcntl

$657United Airlines

Wed, Oct 7 - Wed, Oct 14

5:45 am - 7:31 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

14h 46m2 stops Washington, D.C. Dulles Intl Newark

10:00 am - 10:37 amPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

23h 37m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

$661United Airlines

Sun, Oct 4 - Sun, Oct 11

6:55 pm - 1:02 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

19h 07m2 stops Chicago O'Hare Intl Miami

2:02 pm - 4:18 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

25h 16m2 stops Miami Charlotte Douglas

$692American Airlines

Thu, Oct 8 - Thu, Oct 15

6:05 am - 12:16 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

7h 11m1 stop Miami

1:16 pm - 11:07 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

8h 51m1 stop Miami

$719American Airlines

Sun, Sep 20 - Fri, Sep 25

6:09 pm - 12:16 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

19h 07m2 stops Charlotte Douglas Miami

1:16 pm - 11:26 amPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

21h 10m2 stops Miami Washington, D.C. Reagan-National

$723American Airlines

Sun, Sep 20 - Fri, Sep 25

7:20 pm - 1:55 amTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

31h 35m2 stops Washington, D.C. Dulles Intl San Salvador El Salvador Intl

11:25 am - 10:37 amPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

22h 12m3 stops San José Juan Santamaria Intl Guatemala City La Aurora Washington, D.C. Dulles Intl

$885Avianca

Sat, Sep 19 - Sat, Sep 26

7:00 am - 2:13 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

7h 13m1 stop Miami

4:33 pm - 12:34 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

20h 01m2 stops Miami Charlotte Douglas

$1,064GOL

Wed, Dec 2 - Sun, Jan 3

8:52 pm - 2:13 pmTYS Knoxville McGhee Tyson-PTY Panama City Tocumen Intl

17h 21m2 stops Chicago O'Hare Intl Miami

2:51 pm - 12:34 pmPTY Panama City Tocumen Intl-TYS Knoxville McGhee Tyson

21h 43m2 stops Miami Charlotte Douglas

$1,064GOL

Wed, Dec 2 - Sun, Jan 3

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American Airlines flights from Knoxville to Panama City

Our best American Airlines deals on Knoxville to Panama City flight tickets

American Airlines

Oct 8

TYS6:55 pmKnoxville McGhee Tyson

19h 07m

2 stops

PTY1:02 pmPanama City Tocumen Intl

Oct 15

PTY2:02 pmPanama City Tocumen Intl

25h 16m

2 stops

TYS4:18 pmKnoxville McGhee Tyson

$692

American Airlines

Sep 20

TYS6:05 amKnoxville McGhee Tyson

7h 11m

1 stop

PTY12:16 pmPanama City Tocumen Intl

Sep 25

PTY1:16 pmPanama City Tocumen Intl

8h 51m

1 stop

TYS11:07 pmKnoxville McGhee Tyson

$719

American Airlines

Sep 20

TYS6:09 pmKnoxville McGhee Tyson

19h 07m

2 stops

PTY12:16 pmPanama City Tocumen Intl

Sep 25

PTY1:16 pmPanama City Tocumen Intl

21h 10m

2 stops

TYS11:26 amKnoxville McGhee Tyson

$723

United Airlines flights from Knoxville to Panama City

Our best United Airlines deals on Knoxville to Panama City flight tickets

United Airlines

Oct 7

TYS7:15 amKnoxville McGhee Tyson

7h 59m

1 stop

PTY2:14 pmPanama City Tocumen Intl

Oct 14

PTY9:45 amPanama City Tocumen Intl

10h 00m

1 stop

TYS8:45 pmKnoxville McGhee Tyson

$653

United Airlines

Oct 7

TYS6:00 amKnoxville McGhee Tyson

14h 31m

2 stops

PTY7:31 pmPanama City Tocumen Intl

Oct 14

PTY3:30 pmPanama City Tocumen Intl

20h 44m

2 stops

TYS1:14 pmKnoxville McGhee Tyson

$657

United Airlines

Sep 19

TYS7:15 amKnoxville McGhee Tyson

12h 22m

1 stop

PTY6:37 pmPanama City Tocumen Intl

Sep 26

PTY9:45 amPanama City Tocumen Intl

23h 52m

2 stops

TYS10:37 amKnoxville McGhee Tyson

$661

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Wed 10/7

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Wed 10/14

9:45 am-8:45 pm

1 stop10h 00m

$653

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Wed 10/7

6:00 am-7:31 pm

2 stops14h 31m

Panama City Tocumen Intl

Wed 10/14

3:30 pm-1:14 pm

2 stops20h 44m

$657

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Wed 10/7

5:45 am-7:31 pm

2 stops14h 46m

Panama City Tocumen Intl

Wed 10/14

10:00 am-9:55 pm

1 stop10h 55m

$657

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Sun 10/4

5:45 am-7:31 pm

2 stops14h 46m

Panama City Tocumen Intl

Sun 10/11

10:00 am-10:37 am

2 stops23h 37m

$661

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Thu 10/8

6:55 pm-1:02 pm

2 stops19h 07m

Panama City Tocumen Intl

Thu 10/15

2:02 pm-4:18 pm

2 stops25h 16m

$692

Quickest round-trip

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Sun 9/20

6:05 am-12:16 pm

1 stop7h 11m

Panama City Tocumen Intl

Fri 9/25

1:16 pm-11:07 pm

1 stop8h 51m

$719

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Sun 9/20

6:09 pm-12:16 pm

2 stops19h 07m

Panama City Tocumen Intl

Fri 9/25

1:16 pm-11:26 am

2 stops21h 10m

$723

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Sat 9/19

7:20 pm-1:55 am

2 stops31h 35m

Panama City Tocumen Intl

Sat 9/26

11:25 am-10:37 am

3 stops22h 12m

$885

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Wed 12/2

7:00 am-2:13 pm

1 stop7h 13m

Panama City Tocumen Intl

Sun 1/3

4:33 pm-12:34 pm

2 stops20h 01m

$1,064

KnoxvillePanama City

TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl

TYSPTY

Knoxville McGhee Tyson

Wed 12/2

8:52 pm-2:13 pm

2 stops17h 21m

Panama City Tocumen Intl

Sun 1/3

2:51 pm-12:34 pm

2 stops21h 43m

$1,064

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama City?

In general, July is the cheapest month to fly from Knoxville to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you’re not able to fly to Panama City in July, then April is your next best option. Flight prices from Knoxville to Panama City during April average around $496.

When to book flights from Knoxville to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Panama City according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Knoxville to Panama City (TYS to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama City

Best Price Found	$653
Fastest flight time	7h 59m
Direct flights	None

The best flight deal from Knoxville to Panama City found on momondo in the last 72 hours is $653

The fastest flight from Knoxville to Panama City takes 7h 59m

There are no direct flights from Knoxville to Panama City. There are no popular flight routes from Knoxville to Panama City.

Search flight deals

Frequently asked questions about flying from Knoxville to Panama City

How far is Knoxville McGhee Tyson to Panama City Tocumen Intl by plane?
A flight from Knoxville McGhee Tyson to Panama City Tocumen Intl will travel around 1883.0 mi. Typically, this will take 7h 59m by plane in normal conditions.
When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?
Prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?
There are 3 operators available for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport as of August 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport.
What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?
The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Knoxville to Panama City?
Based on momondo bookings for flights between Knoxville and Panama City, the leading airline is Delta, making up 38% of the total bookings. Other popular airlines include American Airlines with 32% and United Airlines with 30%.

Best airlines flying from Knoxville to Panama City

Compare and see reviews for airlines that fly from Knoxville to Panama City with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $261	Free Cancellation	Rating 7.4 10,121 reviews	Search United Airlines flights
American Airlines	PriceFrom $504	Free Cancellation	Rating 7.1 11,992 reviews	Search American Airlines flights
Delta	PriceFrom $547	Free Cancellation	Rating 7.8 8,529 reviews	Search Delta flights

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Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Panama City?

Once all potential Knoxville to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Puerto Obaldia Airport

Playon Chico Airport

Cheap flights from Knoxville to Panama City from $653

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 10/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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An easier way to manage your Panama City trip

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