Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to Panama City from $587

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 10/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:15 am - 12:16 pm
TYS
-
PTY
7h 01m
1 stop
American Airlines Logo
1:52 pm - 11:24 pm
PTY
-
TYS
8h 32m
1 stop
$587American Airlines
Thu, Oct 1 - Thu, Oct 8
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
3:30 pm - 1:17 pm
PTY
-
TYS
20h 47m
2 stops
$591United Airlines
Wed, Aug 26 - Thu, Aug 27
United Airlines Logo
7:15 am - 2:14 pm
TYS
-
PTY
7h 59m
1 stop
United Airlines Logo
3:30 pm - 9:45 pm
PTY
-
TYS
29h 15m
1 stop
$597United Airlines
Wed, Aug 26 - Thu, Aug 27
United Airlines Logo
7:00 am - 6:37 pm
TYS
-
PTY
12h 37m
2 stops
United Airlines Logo
10:55 pm - 11:59 pm
PTY
-
TYS
24h 04m
2 stops
$606United Airlines
Wed, Aug 26 - Thu, Aug 27
American Airlines Logo
6:06 am - 12:39 pm
TYS
-
PTY
7h 33m
1 stop
American Airlines Logo
1:16 pm - 9:58 pm
PTY
-
TYS
7h 42m
1 stop
$617American Airlines
Sun, Sep 6 - Thu, Sep 17
American Airlines Logo
1:46 pm - 12:39 pm
TYS
-
PTY
23h 53m
2 stops
American Airlines Logo
1:16 pm - 12:30 pm
PTY
-
TYS
22h 14m
2 stops
$621American Airlines
Sun, Sep 6 - Thu, Sep 17
Delta Logo
5:40 am - 12:55 pm
TYS
-
PTY
8h 15m
1 stop
Delta Logo
2:20 pm - 11:52 pm
PTY
-
TYS
8h 32m
1 stop
$627Delta
Tue, Aug 4 - Mon, Aug 17
United Airlines Logo
7:19 pm - 4:12 pm
TYS
-
PTY
21h 53m
2 stops
United Airlines Logo
3:30 pm - 1:17 pm
PTY
-
TYS
20h 47m
2 stops
$631United Airlines
Tue, Aug 4 - Thu, Aug 20
Delta Logo
12:01 pm - 12:55 pm
TYS
-
PTY
25h 54m
1 stop
Delta Logo
2:20 pm - 11:52 pm
PTY
-
TYS
8h 32m
1 stop
$633Delta
Mon, Aug 3 - Tue, Aug 18
United Airlines Logo
6:00 am - 4:04 am
TYS
-
PTY
23h 04m
2 stops
United Airlines Logo
3:30 pm - 1:17 pm
PTY
-
TYS
20h 47m
2 stops
$646United Airlines
Sat, Aug 1 - Wed, Aug 19

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

United Airlines flights from Knoxville to Panama City

Our best United Airlines deals on Knoxville to Panama City flight tickets
United Airlines
Aug 26
TYS7:15 amKnoxville McGhee Tyson
7h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Aug 27
PTY3:30 pmPanama City Tocumen Intl
20h 47m
2 stops
TYS1:17 pmKnoxville McGhee Tyson
$591
United Airlines
Aug 26
TYS7:15 amKnoxville McGhee Tyson
7h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Aug 27
PTY3:30 pmPanama City Tocumen Intl
29h 15m
1 stop
TYS9:45 pmKnoxville McGhee Tyson
$597
United Airlines
Aug 26
TYS7:00 amKnoxville McGhee Tyson
12h 37m
2 stops
PTY6:37 pmPanama City Tocumen Intl
Aug 27
PTY10:55 pmPanama City Tocumen Intl
24h 04m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
$606

American Airlines flights from Knoxville to Panama City

Our best American Airlines deals on Knoxville to Panama City flight tickets
American Airlines
Sep 6
TYS6:06 amKnoxville McGhee Tyson
7h 33m
1 stop
PTY12:39 pmPanama City Tocumen Intl
Sep 17
PTY1:16 pmPanama City Tocumen Intl
7h 42m
1 stop
TYS9:58 pmKnoxville McGhee Tyson
$617
American Airlines
Sep 6
TYS1:46 pmKnoxville McGhee Tyson
23h 53m
2 stops
PTY12:39 pmPanama City Tocumen Intl
Sep 17
PTY1:16 pmPanama City Tocumen Intl
22h 14m
2 stops
TYS12:30 pmKnoxville McGhee Tyson
$621
American Airlines
Aug 2
TYS6:32 pmKnoxville McGhee Tyson
18h 42m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Aug 9
PTY1:39 pmPanama City Tocumen Intl
20h 39m
2 stops
TYS11:18 amKnoxville McGhee Tyson
$666

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 6, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 10/1

6:15 am-12:16 pm

1 stop7h 01m

Panama City Tocumen Intl

Thu 10/8

1:52 pm-11:24 pm

1 stop8h 32m

$587

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 8/26

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Thu 8/27

3:30 pm-1:17 pm

2 stops20h 47m

$591

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 8/26

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Thu 8/27

3:30 pm-9:45 pm

1 stop29h 15m

$597

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 8/26

7:00 am-6:37 pm

2 stops12h 37m

Panama City Tocumen Intl

Thu 8/27

10:55 pm-11:59 pm

2 stops24h 04m

$606
Quickest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 9/6

6:06 am-12:39 pm

1 stop7h 33m

Panama City Tocumen Intl

Thu 9/17

1:16 pm-9:58 pm

1 stop7h 42m

$617

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 9/6

1:46 pm-12:39 pm

2 stops23h 53m

Panama City Tocumen Intl

Thu 9/17

1:16 pm-12:30 pm

2 stops22h 14m

$621

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 8/4

5:40 am-12:55 pm

1 stop8h 15m

Panama City Tocumen Intl

Mon 8/17

2:20 pm-11:52 pm

1 stop8h 32m

$627

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 8/4

7:19 pm-4:12 pm

2 stops21h 53m

Panama City Tocumen Intl

Thu 8/20

3:30 pm-1:17 pm

2 stops20h 47m

$631

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 8/3

12:01 pm-12:55 pm

1 stop25h 54m

Panama City Tocumen Intl

Tue 8/18

2:20 pm-11:52 pm

1 stop8h 32m

$633

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 8/1

6:00 am-4:04 am

2 stops23h 04m

Panama City Tocumen Intl

Wed 8/19

3:30 pm-1:17 pm

2 stops20h 47m

$646

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from Knoxville to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from Knoxville to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $496. If you’re not able to fly to Panama City in April, then October is your next best option. Flight prices from Knoxville to Panama City during October average around $556.

When to book flights from Knoxville to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Panama City (TYS to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama City

Fastest flight time

6h 25m

Direct flights

None
The fastest flight from Knoxville to Panama City takes 6h 25m
There are no direct flights from Knoxville to Panama City. There are no popular flight routes from Knoxville to Panama City.
Search flight deals

Frequently asked questions about flying from Knoxville to Panama City

  • How far is Knoxville McGhee Tyson to Panama City Tocumen Intl by plane?

    A flight from Knoxville McGhee Tyson to Panama City Tocumen Intl will travel around 1883.0 mi. Typically, this will take 6h 25m by plane in normal conditions.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Knoxville to Panama City?

Best airlines flying from Knoxville to Panama City

Compare and see reviews for airlines that fly from Knoxville to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $261Free CancellationRating
7.4
9,938 reviews
Search United Airlines flights
American AirlinesPriceFrom $504Free CancellationRating
7.1
11,782 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Panama City?

Once all potential Knoxville to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Panama City trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 8/5
Wed 8/12
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Panama