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Cheap flights from Houston to Santiago de los Caballeros from $154

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Houston to Santiago de los Caballeros departing on 2/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Houston to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
4:35 pm - 3:33 pm
IAH
-
STI
20h 58m1 stop
Spirit Airlines Logo
4:40 pm - 8:40 am
STI
-
IAH
18h 00m1 stop
$338Spirit Airlines
Fri, Jan 23 - Fri, Jan 30
Multiple Airlines Logo
8:18 pm - 3:33 pm
IAH
-
STI
17h 15m2 stops
Multiple Airlines Logo
4:40 pm - 8:40 am
STI
-
IAH
18h 00m1 stop
$341Multiple Airlines
Fri, Jan 23 - Fri, Jan 30
Spirit Airlines Logo
4:15 pm - 3:33 pm
IAH
-
STI
21h 18m2 stops
Spirit Airlines Logo
4:40 pm - 10:53 pm
STI
-
IAH
32h 13m2 stops
$368Spirit Airlines
Fri, Jan 23 - Fri, Jan 30
Spirit Airlines Logo
4:15 pm - 3:33 pm
IAH
-
STI
21h 18m3 stops
Spirit Airlines Logo
4:40 pm - 10:53 pm
STI
-
IAH
32h 13m2 stops
$392Spirit Airlines
Fri, Jan 23 - Fri, Jan 30
Spirit Airlines Logo
4:35 pm - 3:33 pm
IAH
-
STI
20h 58m1 stop
Spirit Airlines Logo
4:40 pm - 8:40 am
STI
-
IAH
18h 00m1 stop
$413Spirit Airlines
Thu, Jan 8 - Mon, Jan 12
Delta Logo
5:45 am - 12:50 am
HOU
-
STI
17h 05m2 stops
Delta Logo
6:38 am - 10:33 pm
STI
-
HOU
17h 55m2 stops
$562Delta
Sat, Jan 24 - Sat, Jan 31
Delta Logo
10:35 am - 11:27 pm
HOU
-
STI
11h 52m2 stops
Delta Logo
1:30 pm - 9:20 am
STI
-
HOU
20h 50m2 stops
$563Delta
Wed, Apr 8 - Wed, Apr 15
Delta Logo
5:45 am - 12:50 am
HOU
-
STI
17h 05m2 stops
Delta Logo
6:39 am - 10:33 pm
STI
-
HOU
17h 54m2 stops
$583Delta
Fri, Jan 23 - Fri, Jan 30
American Airlines Logo
5:40 am - 9:04 pm
HOU
-
STI
13h 24m2 stops
American Airlines Logo
6:17 pm - 10:05 am
STI
-
HOU
17h 48m2 stops
$1,262American Airlines
Thu, Dec 25 - Mon, Jan 5
American Airlines Logo
5:40 am - 9:04 pm
HOU
-
STI
13h 24m2 stops
American Airlines Logo
6:17 pm - 10:05 am
STI
-
HOU
17h 48m2 stops
$1,367American Airlines
Thu, Dec 25 - Mon, Jan 5

Spirit Airlines flights from Houston to Santiago de los Caballeros

Our best Spirit Airlines deals on Houston to Santiago de los Caballeros flight tickets
Spirit Airlines
Jan 23
IAH4:35 pmHouston George Bush Intcntl
20h 58m
1 stop
STI3:33 pmSantiago de los Caballeros
Jan 30
STI4:40 pmSantiago de los Caballeros
18h 00m
1 stop
IAH8:40 amHouston George Bush Intcntl
$338
Find similar
Spirit Airlines
Jan 23
IAH4:15 pmHouston George Bush Intcntl
21h 18m
2 stops
STI3:33 pmSantiago de los Caballeros
Jan 30
STI4:40 pmSantiago de los Caballeros
32h 13m
2 stops
IAH10:53 pmHouston George Bush Intcntl
$368
Find similar
Spirit Airlines
Jan 23
IAH4:15 pmHouston George Bush Intcntl
21h 18m
3 stops
STI3:33 pmSantiago de los Caballeros
Jan 30
STI4:40 pmSantiago de los Caballeros
32h 13m
2 stops
IAH10:53 pmHouston George Bush Intcntl
$392
Find similar

American Airlines flights from Houston to Santiago de los Caballeros

Our best American Airlines deals on Houston to Santiago de los Caballeros flight tickets
American Airlines
Jan 15
IAH6:05 amHouston George Bush Intcntl
13h 41m
2 stops
STI9:46 pmSantiago de los Caballeros
Jan 20
STI4:33 pmSantiago de los Caballeros
10h 18m
1 stop
IAH12:51 amHouston George Bush Intcntl
$522
Find similar
American Airlines
Jan 8
IAH11:18 amHouston George Bush Intcntl
8h 28m
1 stop
STI9:46 pmSantiago de los Caballeros
Jan 12
STI4:33 pmSantiago de los Caballeros
10h 12m
1 stop
IAH12:45 amHouston George Bush Intcntl
$538
Find similar
American Airlines
May 21
IAH5:35 amHouston George Bush Intcntl
5h 50m
1 stop
STI12:25 pmSantiago de los Caballeros
Jun 4
STI1:40 pmSantiago de los Caballeros
6h 38m
1 stop
IAH7:18 pmHouston George Bush Intcntl
$568
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Houston to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Houston to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Fri 1/23

4:35 pm-3:33 pm

1 stop20h 58m

Santiago de los Caballeros

Fri 1/30

4:40 pm-8:40 am

1 stop18h 00m

$338

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Fri 1/23

8:18 pm-3:33 pm

2 stops17h 15m

Santiago de los Caballeros

Fri 1/30

4:40 pm-8:40 am

1 stop18h 00m

$341

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Fri 1/23

4:15 pm-3:33 pm

2 stops21h 18m

Santiago de los Caballeros

Fri 1/30

4:40 pm-10:53 pm

2 stops32h 13m

$368

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Fri 1/23

4:15 pm-3:33 pm

3 stops21h 18m

Santiago de los Caballeros

Fri 1/30

4:40 pm-10:53 pm

2 stops32h 13m

$392

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Thu 1/8

4:35 pm-3:33 pm

1 stop20h 58m

Santiago de los Caballeros

Mon 1/12

4:40 pm-8:40 am

1 stop18h 00m

$413

HoustonSantiago de los Caballeros

HOU - STI

HOUSTI

Houston Hobby

Sat 1/24

5:45 am-12:50 am

2 stops17h 05m

Santiago de los Caballeros

Sat 1/31

6:38 am-10:33 pm

2 stops17h 55m

$562

HoustonSantiago de los Caballeros

HOU - STI

HOUSTI

Houston Hobby

Wed 4/8

10:35 am-11:27 pm

2 stops11h 52m

Santiago de los Caballeros

Wed 4/15

1:30 pm-9:20 am

2 stops20h 50m

$563

HoustonSantiago de los Caballeros

HOU - STI

HOUSTI

Houston Hobby

Fri 1/23

5:45 am-12:50 am

2 stops17h 05m

Santiago de los Caballeros

Fri 1/30

6:39 am-10:33 pm

2 stops17h 54m

$583

HoustonSantiago de los Caballeros

HOU - STI

HOUSTI

Houston Hobby

Thu 12/25

5:40 am-9:04 pm

2 stops13h 24m

Santiago de los Caballeros

Mon 1/5

6:17 pm-10:05 am

2 stops17h 48m

$1,262

HoustonSantiago de los Caballeros

HOU - STI

HOUSTI

Houston Hobby

Thu 12/25

5:40 am-9:04 pm

2 stops13h 24m

Santiago de los Caballeros

Mon 1/5

6:17 pm-10:05 am

2 stops17h 48m

$1,367

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from Houston to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago de los Caballeros?

The cheapest day to depart from Houston to Santiago de los Caballeros is on a Thursday when prices can be found for as low as $555. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Houston to Santiago de los Caballeros for around $770.

What is the cheapest time of day to depart on your flight to Santiago de los Caballeros?

Our data shows that the cheapest Houston to Santiago de los Caballeros flights are usually those with departure times in the evening. Our users have found flights to Santiago de los Caballeros in the evening for as low as $332. At noon is when there is more demand to fly to Santiago de los Caballeros, so prices are often more expensive at around $762 per ticket.

Cheap Houston to Santiago de los Caballeros flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Houston to Santiago de los Caballeros

Fastest flight time

5h 17m

Direct flights

None
The fastest flight from Houston to Santiago de los Caballeros takes 5h 17m
There are no direct flights from Houston to Santiago de los Caballeros. There are no popular flight routes from Houston to Santiago de los Caballeros.
Search flight deals

  • How far is Houston to Santiago de los Caballeros by plane?

    Santiago de los Caballeros is 1699.3 mi away from Houston. Flights usually cover this in 5h 17m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Houston to Santiago de los Caballeros Airport?

    Prices for flights from Houston to Santiago de los Caballeros Airport were last updated today.

  • How many operators does momondo search for flights from Houston to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from Houston to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Houston to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The necessary travel and health documents for your Santiago de los Caballeros Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Houston to Santiago de los Caballeros

Compare and see reviews for airlines that fly from Houston to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $298Free CancellationRating
6.3
8,174 reviews
Search Spirit Airlines flights
American AirlinesPriceFrom $514Free CancellationRating
7.2
11,048 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Houston to Santiago de los Caballeros?

It is quick and easy to find Houston to Santiago de los Caballeros flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago de los Caballeros that suits you.

Can I find flights from Houston to Santiago de los Caballeros with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Houston to Santiago de los Caballeros flights to just show those with flexible booking policies.

How can momondo help me find flights from Houston to Santiago de los Caballeros?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago de los Caballeros from Houston.

I’m not ready to book a flight from Houston to Santiago de los Caballeros right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Houston to Santiago de los Caballeros flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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