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Cheap flights from Houston to Santiago de los Caballeros from $204

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Houston to Santiago de los Caballeros departing on 11/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Houston to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
2:59 pm - 12:22 pmIAH-STI
19h 23m1 stop
Spirit Airlines Logo
1:17 pm - 9:11 amSTI-IAH
21h 54m1 stop
$331Spirit Airlines
Find Deal
Mon, Nov 10 - Sun, Nov 16
Spirit Airlines Logo
8:47 pm - 12:22 pmIAH-STI
37h 35m2 stops
Spirit Airlines Logo
1:17 pm - 9:11 amSTI-IAH
21h 54m1 stop
$344Spirit Airlines
Find Deal
Mon, Nov 10 - Sun, Nov 16
Spirit Airlines Logo
12:50 pm - 2:42 amIAH-STI
11h 52m2 stops
Spirit Airlines Logo
6:18 pm - 11:30 pmSTI-IAH
7h 12m1 stop
$367Spirit Airlines
Find Deal
Mon, Dec 8 - Wed, Jan 14
Multiple Airlines Logo
6:09 pm - 12:22 pmIAH-STI
16h 13m1 stop
Multiple Airlines Logo
1:17 pm - 10:30 pmSTI-IAH
11h 13m2 stops
$369Multiple Airlines
Find Deal
Thu, Nov 20 - Thu, Nov 27
Spirit Airlines Logo
6:09 pm - 12:22 pmIAH-STI
16h 13m1 stop
Spirit Airlines Logo
1:17 pm - 9:01 amSTI-IAH
21h 44m1 stop
$372Spirit Airlines
Find Deal
Thu, Nov 20 - Thu, Nov 27
Multiple Airlines Logo
2:59 pm - 12:22 pmIAH-STI
19h 23m1 stop
Multiple Airlines Logo
1:17 pm - 7:24 amSTI-IAH
20h 07m2 stops
$417Multiple Airlines
Find Deal
Wed, Nov 19 - Wed, Nov 26
American Airlines Logo
6:28 pm - 3:32 pmIAH-STI
19h 04m2 stops
American Airlines Logo
6:02 am - 5:05 pmSTI-IAH
13h 03m2 stops
$512American Airlines
Find Deal
Mon, Dec 8 - Wed, Jan 14
American Airlines Logo
4:24 pm - 3:32 pmHOU-STI
21h 08m2 stops
American Airlines Logo
6:20 am - 5:52 pmSTI-HOU
13h 32m2 stops
$569American Airlines
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Wed, Nov 19 - Wed, Nov 26
Delta Logo
6:48 pm - 1:06 pmHOU-STI
16h 18m2 stops
Delta Logo
6:40 am - 5:53 pmSTI-HOU
13h 13m2 stops
$592Delta
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Wed, Nov 12 - Thu, Nov 20
Delta Logo
10:05 am - 12:14 amHOU-STI
13h 09m2 stops
Delta Logo
7:15 pm - 4:26 pmSTI-HOU
22h 11m2 stops
$642Delta
Find Deal
Mon, Apr 13 - Fri, Apr 17

Spirit Airlines flights from Houston to Santiago de los Caballeros

Our best Spirit Airlines deals on Houston to Santiago de los Caballeros flight tickets
Spirit Airlines
Nov 10
IAH2:59 pmHouston George Bush Intcntl
19h 23m
1 stop
STI12:22 pmSantiago de los Caballeros
Nov 16
STI1:17 pmSantiago de los Caballeros
21h 54m
1 stop
IAH9:11 amHouston George Bush Intcntl
$331
Find similar
Spirit Airlines
Nov 10
IAH8:47 pmHouston George Bush Intcntl
37h 35m
2 stops
STI12:22 pmSantiago de los Caballeros
Nov 16
STI1:17 pmSantiago de los Caballeros
21h 54m
1 stop
IAH9:11 amHouston George Bush Intcntl
$344
Find similar
Spirit Airlines
Dec 8
IAH12:50 pmHouston George Bush Intcntl
11h 52m
2 stops
STI2:42 amSantiago de los Caballeros
Jan 14
STI6:18 pmSantiago de los Caballeros
7h 12m
1 stop
IAH11:30 pmHouston George Bush Intcntl
$367
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American Airlines flights from Houston to Santiago de los Caballeros

Our best American Airlines deals on Houston to Santiago de los Caballeros flight tickets
American Airlines
Dec 8
IAH6:28 pmHouston George Bush Intcntl
19h 04m
2 stops
STI3:32 pmSantiago de los Caballeros
Jan 14
STI6:02 amSantiago de los Caballeros
13h 03m
2 stops
IAH5:05 pmHouston George Bush Intcntl
$512
Find similar
American Airlines
Nov 19
HOU4:24 pmHouston Hobby
21h 08m
2 stops
STI3:32 pmSantiago de los Caballeros
Nov 26
STI6:20 amSantiago de los Caballeros
13h 32m
2 stops
HOU5:52 pmHouston Hobby
$569
Find similar
American Airlines
Apr 16
HOU6:31 pmHouston Hobby
18h 49m
2 stops
STI2:20 pmSantiago de los Caballeros
Apr 23
STI3:35 pmSantiago de los Caballeros
18h 55m
2 stops
HOU9:30 amHouston Hobby
$572
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momondo Fare Finder

 
Customize your flight search to find flights from Houston to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from Houston to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Mon 11/10

2:59 pm-12:22 pm

1 stop19h 23m

Santiago de los Caballeros

Sun 11/16

1:17 pm-9:11 am

1 stop21h 54m

$331

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Mon 11/10

8:47 pm-12:22 pm

2 stops37h 35m

Santiago de los Caballeros

Sun 11/16

1:17 pm-9:11 am

1 stop21h 54m

$344

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Mon 12/8

12:50 pm-2:42 am

2 stops11h 52m

Santiago de los Caballeros

Wed 1/14

6:18 pm-11:30 pm

1 stop7h 12m

$367

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Thu 11/20

6:09 pm-12:22 pm

1 stop16h 13m

Santiago de los Caballeros

Thu 11/27

1:17 pm-10:30 pm

2 stops11h 13m

$369

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Thu 11/20

6:09 pm-12:22 pm

1 stop16h 13m

Santiago de los Caballeros

Thu 11/27

1:17 pm-9:01 am

1 stop21h 44m

$372

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Wed 11/19

2:59 pm-12:22 pm

1 stop19h 23m

Santiago de los Caballeros

Wed 11/26

1:17 pm-7:24 am

2 stops20h 07m

$417

HoustonSantiago de los Caballeros

IAH - STI

IAHSTI

Houston George Bush Intcntl

Mon 12/8

6:28 pm-3:32 pm

2 stops19h 04m

Santiago de los Caballeros

Wed 1/14

6:02 am-5:05 pm

2 stops13h 03m

$512

HoustonSantiago de los Caballeros

HOU - STI

HOUSTI

Houston Hobby

Wed 11/19

4:24 pm-3:32 pm

2 stops21h 08m

Santiago de los Caballeros

Wed 11/26

6:20 am-5:52 pm

2 stops13h 32m

$569

HoustonSantiago de los Caballeros

HOU - STI

HOUSTI

Houston Hobby

Wed 11/12

6:48 pm-1:06 pm

2 stops16h 18m

Santiago de los Caballeros

Thu 11/20

6:40 am-5:53 pm

2 stops13h 13m

$592

HoustonSantiago de los Caballeros

HOU - STI

HOUSTI

Houston Hobby

Mon 4/13

10:05 am-12:14 am

2 stops13h 09m

Santiago de los Caballeros

Fri 4/17

7:15 pm-4:26 pm

2 stops22h 11m

$642

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from Houston to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Houston and Santiago de los Caballeros?

What is the cheapest day to depart on your flight to Santiago de los Caballeros?

The cheapest day to depart from Houston to Santiago de los Caballeros is on a Thursday when prices can be found for as low as $555. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Houston to Santiago de los Caballeros for around $770.

What is the cheapest time of day to depart on your flight to Santiago de los Caballeros?

Our data shows that the cheapest Houston to Santiago de los Caballeros flights are usually those with departure times in the evening. Our users have found flights to Santiago de los Caballeros in the evening for as low as $332. At noon is when there is more demand to fly to Santiago de los Caballeros, so prices are often more expensive at around $762 per ticket.

Cheap Houston to Santiago de los Caballeros flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Houston to Santiago de los Caballeros

Direct flights

None
There are no direct flights from Houston to Santiago de los Caballeros. There are no popular flight routes from Houston to Santiago de los Caballeros.
Search flight deals

  • How far is Houston to Santiago de los Caballeros by plane?

    Santiago de los Caballeros is 1699.3 mi away from Houston. Flights usually cover this in 5h 12m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Houston to Santiago de los Caballeros Airport?

    Prices for flights from Houston to Santiago de los Caballeros Airport were last updated today.

  • How many operators does momondo search for flights from Houston to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from Houston to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Houston to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The necessary travel and health documents for your Santiago de los Caballeros Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Houston to Santiago de los Caballeros

Compare and see reviews for airlines that fly from Houston to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $298Free CancellationRating
6.3
8,104 reviews
Search Spirit Airlines flights
American AirlinesPriceFrom $514Free CancellationRating
7.2
11,033 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Houston to Santiago de los Caballeros?

It is quick and easy to find Houston to Santiago de los Caballeros flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago de los Caballeros that suits you.

Can I find flights from Houston to Santiago de los Caballeros with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Houston to Santiago de los Caballeros flights to just show those with flexible booking policies.

How can momondo help me find flights from Houston to Santiago de los Caballeros?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago de los Caballeros from Houston.

I’m not ready to book a flight from Houston to Santiago de los Caballeros right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Houston to Santiago de los Caballeros flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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