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Cheap flights from Houston to Santiago from $262

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Houston to Santiago departing on 1/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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Multiple Airlines Logo
4:10 pm - 3:35 amIAH-SCL
32h 25m2 stops
Multiple Airlines Logo
10:35 am - 11:16 pmSCL-IAH
15h 41m1 stop
$571Multiple Airlines
Find Deal
Wed, Dec 31 - Sat, Jan 24
Multiple Airlines Logo
12:13 pm - 10:15 pmIAH-SCL
31h 02m2 stops
Multiple Airlines Logo
11:25 pm - 3:16 pmSCL-IAH
18h 51m1 stop
$578Multiple Airlines
Find Deal
Thu, Jan 15 - Wed, Jan 28
Multiple Airlines Logo
4:10 pm - 3:35 amIAH-SCL
32h 25m2 stops
Multiple Airlines Logo
10:35 am - 11:59 pmSCL-IAH
16h 24m1 stop
$580Multiple Airlines
Find Deal
Wed, Dec 31 - Mon, Jan 26
Multiple Airlines Logo
4:10 pm - 3:35 amIAH-SCL
32h 25m2 stops
Multiple Airlines Logo
11:25 pm - 3:08 pmSCL-IAH
18h 43m1 stop
$583Multiple Airlines
Find Deal
Wed, Dec 31 - Tue, Jan 27
Delta Logo
11:09 am - 11:35 amHOU-SCL
21h 26m2 stops
Delta Logo
12:20 am - 10:28 pmSCL-HOU
25h 08m2 stops
$964Delta
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Mon, Feb 2 - Mon, Feb 16
Delta Logo
5:45 am - 5:35 amHOU-SCL
20h 50m2 stops
Delta Logo
11:10 pm - 10:21 amSCL-HOU
14h 11m1 stop
$969Delta
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Thu, Jan 15 - Wed, Jan 28
LATAM Airlines Logo
11:09 am - 6:35 amHOU-SCL
16h 26m2 stops
LATAM Airlines Logo
4:35 am - 10:33 pmSCL-HOU
20h 58m2 stops
$988LATAM Airlines
Find Deal
Thu, Jan 22 - Fri, Jan 30
LATAM Airlines Logo
5:35 pm - 2:05 pmHOU-SCL
17h 30m2 stops
LATAM Airlines Logo
4:35 am - 10:28 pmSCL-HOU
20h 53m2 stops
$996LATAM Airlines
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Sat, Feb 14 - Sun, Mar 1
American Airlines Logo
10:15 am - 7:55 amHOU-SCL
18h 40m1 stop
American Airlines Logo
10:15 pm - 11:48 amSCL-HOU
15h 33m1 stop
$1,007American Airlines
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Sat, Feb 28 - Tue, Mar 10
American Airlines Logo
9:04 am - 8:15 amHOU-SCL
20h 11m1 stop
American Airlines Logo
10:30 pm - 8:34 amSCL-HOU
13h 04m1 stop
$1,089American Airlines
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Thu, Jan 8 - Thu, Jan 15

Delta flights from Houston to Santiago

Our best Delta deals on Houston to Santiago flight tickets
Delta
Feb 2
HOU11:09 amHouston Hobby
21h 26m
2 stops
SCL11:35 amSantiago Arturo Merino Benitez
Feb 16
SCL12:20 amSantiago Arturo Merino Benitez
25h 08m
2 stops
HOU10:28 pmHouston Hobby
$964
Find similar
Delta
Jan 29
HOU5:45 amHouston Hobby
20h 50m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
Feb 5
SCL11:55 pmSantiago Arturo Merino Benitez
25h 38m
2 stops
HOU10:33 pmHouston Hobby
$969
Find similar
Delta
May 15
HOU10:05 amHouston Hobby
18h 55m
2 stops
SCL6:00 amSantiago Arturo Merino Benitez
Jun 1
SCL11:25 pmSantiago Arturo Merino Benitez
23h 13m
2 stops
HOU9:38 pmHouston Hobby
$1,004
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LATAM Airlines flights from Houston to Santiago

Our best LATAM Airlines deals on Houston to Santiago flight tickets
LATAM Airlines
Jan 22
HOU11:09 amHouston Hobby
16h 26m
2 stops
SCL6:35 amSantiago Arturo Merino Benitez
Jan 30
SCL4:35 amSantiago Arturo Merino Benitez
20h 58m
2 stops
HOU10:33 pmHouston Hobby
$988
Find similar
LATAM Airlines
Feb 14
HOU5:35 pmHouston Hobby
20h 55m
2 stops
SCL5:30 pmSantiago Arturo Merino Benitez
Mar 2
SCL5:15 amSantiago Arturo Merino Benitez
20h 13m
2 stops
HOU10:28 pmHouston Hobby
$996
Find similar
LATAM Airlines
May 1
HOU1:00 pmHouston Hobby
15h 35m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
May 13
SCL6:45 pmSantiago Arturo Merino Benitez
18h 25m
2 stops
HOU12:10 pmHouston Hobby
$1,001
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momondo Fare Finder

 
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Wed 12/31

4:10 pm-3:35 am

2 stops32h 25m

Santiago Arturo Merino Benitez

Sat 1/24

10:35 am-11:16 pm

1 stop15h 41m

$571

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 1/15

12:13 pm-10:15 pm

2 stops31h 02m

Santiago Arturo Merino Benitez

Wed 1/28

11:25 pm-3:16 pm

1 stop18h 51m

$578

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Wed 12/31

4:10 pm-3:35 am

2 stops32h 25m

Santiago Arturo Merino Benitez

Mon 1/26

10:35 am-11:59 pm

1 stop16h 24m

$580

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Wed 12/31

4:10 pm-3:35 am

2 stops32h 25m

Santiago Arturo Merino Benitez

Tue 1/27

11:25 pm-3:08 pm

1 stop18h 43m

$583

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 2/2

11:09 am-11:35 am

2 stops21h 26m

Santiago Arturo Merino Benitez

Mon 2/16

12:20 am-10:28 pm

2 stops25h 08m

$964

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Thu 1/15

5:45 am-5:35 am

2 stops20h 50m

Santiago Arturo Merino Benitez

Wed 1/28

11:10 pm-10:21 am

1 stop14h 11m

$969

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Thu 1/22

11:09 am-6:35 am

2 stops16h 26m

Santiago Arturo Merino Benitez

Fri 1/30

4:35 am-10:33 pm

2 stops20h 58m

$988

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Sat 2/14

5:35 pm-2:05 pm

2 stops17h 30m

Santiago Arturo Merino Benitez

Sun 3/1

4:35 am-10:28 pm

2 stops20h 53m

$996

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Sat 2/28

10:15 am-7:55 am

1 stop18h 40m

Santiago Arturo Merino Benitez

Tue 3/10

10:15 pm-11:48 am

1 stop15h 33m

$1,007

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Thu 1/8

9:04 am-8:15 am

1 stop20h 11m

Santiago Arturo Merino Benitez

Thu 1/15

10:30 pm-8:34 am

1 stop13h 04m

$1,089

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Houston to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Houston and Santiago?

What is the cheapest month to fly to Santiago?

In general, April is the cheapest month to fly from Houston to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $798. If you don’t want to visit Santiago in April, then you should wait until May to fly from Houston, when ticket prices are also cheap, with an average price of $847.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $1,037. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,557.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Houston to Santiago when you can find flight prices for as low as $981. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,467 per ticket.

What is the cheapest Houston to Santiago Arturo Merino Benitez flight route?

Fly from Houston George Bush Intcntl to Santiago Arturo Merino Benitez for the best Houston - Santiago Arturo Merino Benitez flight prices

What cabin class options are available on Houston to Santiago Arturo Merino Benitez flights?

There are 3 cabin classes available to choose from on Houston to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Houston to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Houston to Santiago

Fastest flight time

9h 05m

Direct flights

Every day

Airports in Santiago

1 airport
The fastest flight from Houston to Santiago takes 9h 05m
Direct flights go from Houston to Santiago every day.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
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  • How far is Houston to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Houston to Santiago Arturo Merino Benitez is 4652.9 mi. A reasonable flight in good conditions will take 12h 20m.

  • When did momondo last update prices for flights from Houston to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Houston to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Houston to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Houston to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Houston to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Houston to Santiago

Compare and see reviews for airlines that fly from Houston to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $499Free CancellationRating
6.6
2,477 reviews
Search Avianca flights
United AirlinesPriceFrom $949Free CancellationRating
7.4
9,047 reviews
Search United Airlines flights
DeltaPriceFrom $963Free CancellationRating
7.9
8,000 reviews
Search Delta flights
LATAM AirlinesPriceFrom $963Free CancellationRating
7.5
1,886 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $1,242Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Houston to Santiago?

It is quick and easy to find Houston to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Houston to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from Houston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Houston to Santiago?

Once you have performed a search for Houston to Santiago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Houston to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Houston to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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