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Cheap flights from Houston to Santiago from $286

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Houston to Santiago departing on 1/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Multiple Airlines Logo
5:25 pm - 8:15 amIAH-SCL
35h 50m2 stops
Multiple Airlines Logo
7:25 am - 7:04 amSCL-IAH
26h 39m2 stops
$582Multiple Airlines
Find Deal
Thu, Dec 4 - Wed, Dec 10
Multiple Airlines Logo
5:25 pm - 8:15 amIAH-SCL
35h 50m2 stops
Multiple Airlines Logo
7:15 am - 7:04 amSCL-IAH
26h 49m2 stops
$591Multiple Airlines
Find Deal
Thu, Dec 4 - Tue, Dec 9
Multiple Airlines Logo
5:25 pm - 8:15 amIAH-SCL
35h 50m2 stops
Multiple Airlines Logo
11:25 pm - 2:03 pmSCL-IAH
17h 38m1 stop
$595Multiple Airlines
Find Deal
Thu, Dec 4 - Mon, Dec 8
LATAM Airlines Logo
5:45 am - 6:10 amHOU-SCL
21h 25m1 stop
LATAM Airlines Logo
11:10 pm - 10:21 amSCL-HOU
14h 11m1 stop
$951LATAM Airlines
Find Deal
Mon, Jan 5 - Mon, Jan 19
Delta Logo
5:45 am - 6:10 amHOU-SCL
21h 25m1 stop
Delta Logo
8:15 am - 10:33 pmSCL-HOU
17h 18m2 stops
$956Delta
Find Deal
Mon, Jan 5 - Mon, Jan 19
Delta Logo
11:09 am - 11:35 amHOU-SCL
21h 26m2 stops
Delta Logo
12:20 pm - 12:21 pmSCL-HOU
27h 01m2 stops
$964Delta
Find Deal
Mon, Feb 2 - Tue, Feb 17
LATAM Airlines Logo
11:09 am - 7:40 amHOU-SCL
17h 31m1 stop
LATAM Airlines Logo
11:10 pm - 10:21 amSCL-HOU
14h 11m1 stop
$986LATAM Airlines
Find Deal
Tue, Jan 6 - Wed, Jan 28
LATAM Airlines Logo
1:00 pm - 7:00 amHOU-SCL
16h 00m1 stop
LATAM Airlines Logo
8:40 pm - 12:21 pmSCL-HOU
17h 41m1 stop
$992LATAM Airlines
Find Deal
Fri, Mar 20 - Tue, Mar 31
LATAM Airlines Logo
10:05 am - 6:35 amHOU-SCL
18h 30m2 stops
LATAM Airlines Logo
11:25 pm - 9:46 pmSCL-HOU
23h 21m2 stops
$996LATAM Airlines
Find Deal
Sun, Mar 22 - Sun, Apr 5
Delta Logo
1:00 pm - 7:00 amHOU-SCL
17h 00m1 stop
Delta Logo
8:40 pm - 12:10 pmSCL-HOU
16h 30m1 stop
$1,004Delta
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Fri, May 15 - Mon, Jun 1

LATAM Airlines flights from Houston to Santiago

Our best LATAM Airlines deals on Houston to Santiago flight tickets
LATAM Airlines
Jan 5
HOU5:45 amHouston Hobby
21h 25m
1 stop
SCL6:10 amSantiago Arturo Merino Benitez
Jan 19
SCL11:10 pmSantiago Arturo Merino Benitez
14h 11m
1 stop
HOU10:21 amHouston Hobby
$951
Find similar
LATAM Airlines
Jan 6
HOU11:09 amHouston Hobby
17h 31m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Jan 28
SCL11:10 pmSantiago Arturo Merino Benitez
14h 11m
1 stop
HOU10:21 amHouston Hobby
$986
Find similar
LATAM Airlines
Mar 20
HOU1:00 pmHouston Hobby
16h 00m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Mar 31
SCL8:40 pmSantiago Arturo Merino Benitez
17h 41m
1 stop
HOU12:21 pmHouston Hobby
$992
Find similar

Delta flights from Houston to Santiago

Our best Delta deals on Houston to Santiago flight tickets
Delta
Jan 5
HOU5:45 amHouston Hobby
21h 25m
1 stop
SCL6:10 amSantiago Arturo Merino Benitez
Jan 19
SCL8:15 amSantiago Arturo Merino Benitez
17h 18m
2 stops
HOU10:33 pmHouston Hobby
$956
Find similar
Delta
Feb 2
HOU11:09 amHouston Hobby
22h 41m
2 stops
SCL12:50 pmSantiago Arturo Merino Benitez
Feb 16
SCL12:20 amSantiago Arturo Merino Benitez
24h 10m
2 stops
HOU9:30 pmHouston Hobby
$964
Find similar
Delta
May 1
HOU10:05 amHouston Hobby
18h 45m
2 stops
SCL5:50 amSantiago Arturo Merino Benitez
May 13
SCL10:35 amSantiago Arturo Merino Benitez
26h 35m
2 stops
HOU12:10 pmHouston Hobby
$1,004
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 17, 2025.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 12/4

5:25 pm-8:15 am

2 stops35h 50m

Santiago Arturo Merino Benitez

Wed 12/10

7:25 am-7:04 am

2 stops26h 39m

$582

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 12/4

5:25 pm-8:15 am

2 stops35h 50m

Santiago Arturo Merino Benitez

Tue 12/9

7:15 am-7:04 am

2 stops26h 49m

$591

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 12/4

5:25 pm-8:15 am

2 stops35h 50m

Santiago Arturo Merino Benitez

Mon 12/8

11:25 pm-2:03 pm

1 stop17h 38m

$595

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 1/5

5:45 am-6:10 am

1 stop21h 25m

Santiago Arturo Merino Benitez

Mon 1/19

11:10 pm-10:21 am

1 stop14h 11m

$951

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 1/5

5:45 am-6:10 am

1 stop21h 25m

Santiago Arturo Merino Benitez

Mon 1/19

8:15 am-10:33 pm

2 stops17h 18m

$956

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 2/2

11:09 am-11:35 am

2 stops21h 26m

Santiago Arturo Merino Benitez

Tue 2/17

12:20 pm-12:21 pm

2 stops27h 01m

$964

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Tue 1/6

11:09 am-7:40 am

1 stop17h 31m

Santiago Arturo Merino Benitez

Wed 1/28

11:10 pm-10:21 am

1 stop14h 11m

$986

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Fri 3/20

1:00 pm-7:00 am

1 stop16h 00m

Santiago Arturo Merino Benitez

Tue 3/31

8:40 pm-12:21 pm

1 stop17h 41m

$992

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Sun 3/22

10:05 am-6:35 am

2 stops18h 30m

Santiago Arturo Merino Benitez

Sun 4/5

11:25 pm-9:46 pm

2 stops23h 21m

$996

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Fri 5/15

1:00 pm-7:00 am

1 stop17h 00m

Santiago Arturo Merino Benitez

Mon 6/1

8:40 pm-12:10 pm

1 stop16h 30m

$1,004

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Houston to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Houston and Santiago?

What is the cheapest month to fly to Santiago?

In general, April is the cheapest month to fly from Houston to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $798. If you don’t want to visit Santiago in April, then you should wait until May to fly from Houston, when ticket prices are also cheap, with an average price of $847.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $1,037. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,557.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Houston to Santiago when you can find flight prices for as low as $981. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,499 per ticket.

What is the cheapest Houston to Santiago Arturo Merino Benitez flight route?

Fly from Houston George Bush Intcntl to Santiago Arturo Merino Benitez for the best Houston - Santiago Arturo Merino Benitez flight prices

What cabin class options are available on Houston to Santiago Arturo Merino Benitez flights?

There are 3 cabin classes available to choose from on Houston to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Houston to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Houston to Santiago

Fastest flight time

9h 05m

Direct flights

Every day

Airports in Santiago

1 airport
The fastest flight from Houston to Santiago takes 9h 05m
Direct flights go from Houston to Santiago every day.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
Search flight deals

  • How far is Houston to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Houston to Santiago Arturo Merino Benitez is 4652.9 mi. A reasonable flight in good conditions will take 12h 35m.

  • When did momondo last update prices for flights from Houston to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Houston to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Houston to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Houston to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Houston to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Houston to Santiago

Compare and see reviews for airlines that fly from Houston to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $499Free CancellationRating
6.6
2,476 reviews
Search Avianca flights
United AirlinesPriceFrom $949Free CancellationRating
7.4
9,014 reviews
Search United Airlines flights
DeltaPriceFrom $963Free CancellationRating
7.9
8,006 reviews
Search Delta flights
LATAM AirlinesPriceFrom $963Free CancellationRating
7.5
1,877 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $1,242Free CancellationRating
7.2
11,046 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Houston to Santiago?

It is quick and easy to find Houston to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Houston to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from Houston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Houston to Santiago?

Once you have performed a search for Houston to Santiago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Houston to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Houston to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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