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Cheap flights from Houston to Santiago from $348

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Houston to Santiago departing on 3/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:25 pm - 5:50 amIAH-SCL
33h 25m2 stops
Multiple Airlines Logo
5:50 am - 11:59 pmSCL-IAH
21h 09m2 stops
$601Multiple Airlines
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Sat, Dec 6 - Sun, Dec 14
Multiple Airlines Logo
5:00 am - 12:15 pmIAH-SCL
28h 15m3 stops
Multiple Airlines Logo
5:50 am - 11:59 pmSCL-IAH
21h 09m2 stops
$617Multiple Airlines
Find Deal
Sat, Dec 6 - Sun, Dec 14
Multiple Airlines Logo
5:25 pm - 5:50 amIAH-SCL
33h 25m2 stops
Multiple Airlines Logo
11:25 pm - 11:59 pmSCL-IAH
27h 34m1 stop
$623Multiple Airlines
Find Deal
Sat, Dec 6 - Sun, Dec 14
Multiple Airlines Logo
5:27 pm - 10:15 pmIAH-SCL
25h 48m2 stops
Multiple Airlines Logo
9:29 pm - 5:56 pmSCL-IAH
23h 27m2 stops
$642Multiple Airlines
Find Deal
Sat, Jan 10 - Tue, Jan 20
Air Canada Logo
10:03 am - 12:15 pmIAH-SCL
23h 12m1 stop
Air Canada Logo
8:55 pm - 6:45 pmSCL-IAH
24h 50m1 stop
$660Air Canada
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Mon, Feb 9 - Tue, Feb 17
Multiple Airlines Logo
5:00 am - 12:15 pmIAH-SCL
28h 15m3 stops
Multiple Airlines Logo
7:25 am - 11:59 pmSCL-IAH
43h 34m3 stops
$665Multiple Airlines
Find Deal
Sat, Dec 6 - Sun, Dec 14
Delta Logo
10:46 am - 5:50 amHOU-SCL
16h 04m2 stops
Delta Logo
8:10 am - 10:35 pmSCL-HOU
17h 25m2 stops
$955Delta
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Thu, Jan 1 - Thu, Jan 15
Delta Logo
10:46 am - 5:50 amHOU-SCL
16h 04m2 stops
Delta Logo
6:30 pm - 10:21 amSCL-HOU
18h 51m2 stops
$957Delta
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Thu, Jan 1 - Wed, Jan 14
LATAM Airlines Logo
5:35 am - 7:40 amHOU-SCL
23h 05m1 stop
LATAM Airlines Logo
8:40 pm - 12:10 pmSCL-HOU
16h 30m1 stop
$986LATAM Airlines
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Mon, Jan 12 - Wed, May 13
LATAM Airlines Logo
5:19 pm - 2:05 pmHOU-SCL
17h 46m2 stops
LATAM Airlines Logo
11:15 pm - 12:21 pmSCL-HOU
16h 06m1 stop
$988LATAM Airlines
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Fri, Feb 13 - Tue, Feb 24

American Airlines flights from Houston to Santiago

Our best American Airlines deals on Houston to Santiago flight tickets
American Airlines
Dec 24
HOU10:13 amHouston Hobby
18h 42m
2 stops
SCL7:55 amSantiago Arturo Merino Benitez
Jan 12
SCL10:35 pmSantiago Arturo Merino Benitez
16h 34m
2 stops
HOU12:09 pmHouston Hobby
$1,200
Find similar
American Airlines
Dec 22
HOU12:09 pmHouston Hobby
16h 36m
1 stop
SCL7:45 amSantiago Arturo Merino Benitez
Jan 12
SCL10:35 pmSantiago Arturo Merino Benitez
16h 34m
2 stops
HOU12:09 pmHouston Hobby
$1,325
Find similar
American Airlines
Dec 22
HOU4:17 pmHouston Hobby
14h 08m
2 stops
SCL9:25 amSantiago Arturo Merino Benitez
Jan 12
SCL10:35 pmSantiago Arturo Merino Benitez
16h 34m
2 stops
HOU12:09 pmHouston Hobby
$1,328
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LATAM Airlines flights from Houston to Santiago

Our best LATAM Airlines deals on Houston to Santiago flight tickets
LATAM Airlines
Jan 12
HOU5:35 amHouston Hobby
23h 05m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
May 13
SCL8:40 pmSantiago Arturo Merino Benitez
16h 30m
1 stop
HOU12:10 pmHouston Hobby
$986
Find similar
LATAM Airlines
Feb 13
HOU5:19 pmHouston Hobby
17h 46m
2 stops
SCL2:05 pmSantiago Arturo Merino Benitez
Feb 24
SCL11:15 pmSantiago Arturo Merino Benitez
16h 06m
1 stop
HOU12:21 pmHouston Hobby
$988
Find similar
LATAM Airlines
May 1
HOU5:35 pmHouston Hobby
12h 25m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
May 13
SCL4:55 pmSantiago Arturo Merino Benitez
20h 15m
2 stops
HOU12:10 pmHouston Hobby
$996
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Sat 12/6

5:25 pm-5:50 am

2 stops33h 25m

Santiago Arturo Merino Benitez

Sun 12/14

5:50 am-11:59 pm

2 stops21h 09m

$601

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Sat 12/6

5:00 am-12:15 pm

3 stops28h 15m

Santiago Arturo Merino Benitez

Sun 12/14

5:50 am-11:59 pm

2 stops21h 09m

$617

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Sat 12/6

5:25 pm-5:50 am

2 stops33h 25m

Santiago Arturo Merino Benitez

Sun 12/14

11:25 pm-11:59 pm

1 stop27h 34m

$623

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Sat 1/10

5:27 pm-10:15 pm

2 stops25h 48m

Santiago Arturo Merino Benitez

Tue 1/20

9:29 pm-5:56 pm

2 stops23h 27m

$642

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Mon 2/9

10:03 am-12:15 pm

1 stop23h 12m

Santiago Arturo Merino Benitez

Tue 2/17

8:55 pm-6:45 pm

1 stop24h 50m

$660

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Sat 12/6

5:00 am-12:15 pm

3 stops28h 15m

Santiago Arturo Merino Benitez

Sun 12/14

7:25 am-11:59 pm

3 stops43h 34m

$665

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Thu 1/1

10:46 am-5:50 am

2 stops16h 04m

Santiago Arturo Merino Benitez

Thu 1/15

8:10 am-10:35 pm

2 stops17h 25m

$955

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Thu 1/1

10:46 am-5:50 am

2 stops16h 04m

Santiago Arturo Merino Benitez

Wed 1/14

6:30 pm-10:21 am

2 stops18h 51m

$957

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 1/12

5:35 am-7:40 am

1 stop23h 05m

Santiago Arturo Merino Benitez

Wed 5/13

8:40 pm-12:10 pm

1 stop16h 30m

$986

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Fri 2/13

5:19 pm-2:05 pm

2 stops17h 46m

Santiago Arturo Merino Benitez

Tue 2/24

11:15 pm-12:21 pm

1 stop16h 06m

$988

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Houston to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Houston and Santiago?

What is the cheapest month to fly to Santiago?

In general, April is the cheapest month to fly from Houston to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $798. If you don’t want to visit Santiago in April, then you should wait until May to fly from Houston, when ticket prices are also cheap, with an average price of $847.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $1,037. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,557.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Houston to Santiago when you can find flight prices for as low as $981. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,499 per ticket.

What is the cheapest Houston to Santiago Arturo Merino Benitez flight route?

Fly from Houston George Bush Intcntl to Santiago Arturo Merino Benitez for the best Houston - Santiago Arturo Merino Benitez flight prices

What cabin class options are available on Houston to Santiago Arturo Merino Benitez flights?

There are 3 cabin classes available to choose from on Houston to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Houston to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Houston to Santiago

Fastest flight time

9h 05m

Direct flights

Mon, Tue, Thu, Fri, Sat and Sun

Airports in Santiago

1 airport
The fastest flight from Houston to Santiago takes 9h 05m
Direct flights go from Houston to Santiago on Monday, Tuesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
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  • How far is Houston to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Houston to Santiago Arturo Merino Benitez is 4652.9 mi. A reasonable flight in good conditions will take 12h 25m.

  • When did momondo last update prices for flights from Houston to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Houston to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Houston to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Houston to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Houston to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Houston to Santiago

Compare and see reviews for airlines that fly from Houston to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $499Free CancellationRating
6.6
2,475 reviews
Search Avianca flights
United AirlinesPriceFrom $949Free CancellationRating
7.4
9,015 reviews
Search United Airlines flights
DeltaPriceFrom $963Free CancellationRating
7.9
8,008 reviews
Search Delta flights
LATAM AirlinesPriceFrom $963Free CancellationRating
7.5
1,875 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $1,242Free CancellationRating
7.2
11,049 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Houston to Santiago?

It is quick and easy to find Houston to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Houston to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from Houston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Houston to Santiago?

Once you have performed a search for Houston to Santiago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Houston to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Houston to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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