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Cheap flights from Houston to Santiago from $273

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Houston to Santiago departing on 11/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Houston to Santiago

Cheap round-trip flights

Logo
6:20 am - 3:35 amIAH-SCL
19h 15m2 stops
Logo
3:30 pm - 5:37 pmSCL-IAH
28h 07m3 stops
$593
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Thu, Oct 9 - Wed, Oct 22
Logo
6:59 pm - 3:35 amIAH-SCL
30h 36m2 stops
Logo
11:00 am - 9:07 pmSCL-IAH
36h 07m1 stop
$598
Find Deal
Mon, Sep 15 - Mon, Sep 22
Logo
7:00 am - 3:35 amIAH-SCL
17h 35m2 stops
Logo
11:25 pm - 1:39 pmSCL-IAH
17h 14m1 stop
$605
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Tue, Nov 11 - Thu, Nov 13
Logo
2:48 pm - 3:35 amIAH-SCL
34h 47m2 stops
Logo
10:50 am - 5:37 pmSCL-IAH
32h 47m1 stop
$609
Find Deal
Wed, Oct 22 - Wed, Oct 29
LATAM Airlines Logo
5:00 pm - 2:05 pmHOU-SCL
18h 05m2 stops
LATAM Airlines Logo
11:15 pm - 9:32 amSCL-HOU
13h 17m1 stop
$957LATAM Airlines
Find Deal
Mon, Feb 2 - Tue, Feb 17
Delta Logo
10:13 am - 7:00 amHOU-SCL
18h 47m1 stop
Delta Logo
2:20 pm - 1:27 pmSCL-HOU
25h 07m2 stops
$964Delta
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Thu, Oct 9 - Wed, Oct 22
LATAM Airlines Logo
5:35 pm - 3:30 pmHOU-SCL
18h 55m2 stops
LATAM Airlines Logo
12:25 am - 9:46 pmSCL-HOU
24h 21m2 stops
$997LATAM Airlines
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Sat, Feb 14 - Sun, Mar 1
Delta Logo
6:00 am - 6:00 amHOU-SCL
21h 00m2 stops
Delta Logo
11:25 pm - 9:40 pmSCL-HOU
25h 15m2 stops
$1,048Delta
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Fri, Nov 21 - Sun, Nov 30
American Airlines Logo
10:20 am - 7:50 amHOU-SCL
18h 30m1 stop
American Airlines Logo
11:15 pm - 11:27 amSCL-HOU
15h 12m1 stop
$1,056American Airlines
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Thu, Dec 25 - Mon, Jan 12
American Airlines Logo
10:03 am - 8:00 amHOU-SCL
19h 57m2 stops
American Airlines Logo
9:55 pm - 4:09 pmSCL-HOU
20h 14m2 stops
$1,093American Airlines
Find Deal
Mon, Oct 6 - Mon, Oct 20

Delta flights from Houston to Santiago

Our best Delta deals on Houston to Santiago flight tickets
Delta
Oct 9
HOU10:13 amHouston Hobby
18h 47m
1 stop
SCL7:00 amSantiago Arturo Merino Benitez
Oct 22
SCL2:20 pmSantiago Arturo Merino Benitez
25h 07m
2 stops
HOU1:27 pmHouston Hobby
$964
Find similar
Delta
Nov 21
HOU6:00 amHouston Hobby
21h 00m
2 stops
SCL6:00 amSantiago Arturo Merino Benitez
Nov 30
SCL11:25 pmSantiago Arturo Merino Benitez
25h 15m
2 stops
HOU9:40 pmHouston Hobby
$1,048
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Delta
Dec 25
HOU6:03 amHouston Hobby
21h 37m
2 stops
SCL6:40 amSantiago Arturo Merino Benitez
Jan 12
SCL8:20 amSantiago Arturo Merino Benitez
28h 12m
2 stops
HOU9:32 amHouston Hobby
$1,089
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LATAM Airlines flights from Houston to Santiago

Our best LATAM Airlines deals on Houston to Santiago flight tickets
LATAM Airlines
Feb 2
HOU5:00 pmHouston Hobby
18h 05m
2 stops
SCL2:05 pmSantiago Arturo Merino Benitez
Feb 17
SCL11:15 pmSantiago Arturo Merino Benitez
13h 17m
1 stop
HOU9:32 amHouston Hobby
$957
Find similar
LATAM Airlines
Feb 14
HOU5:35 pmHouston Hobby
18h 55m
2 stops
SCL3:30 pmSantiago Arturo Merino Benitez
Mar 1
SCL12:25 amSantiago Arturo Merino Benitez
24h 21m
2 stops
HOU9:46 pmHouston Hobby
$997
Find similar
LATAM Airlines
Feb 14
HOU5:35 pmHouston Hobby
21h 20m
2 stops
SCL5:55 pmSantiago Arturo Merino Benitez
Mar 1
SCL12:25 amSantiago Arturo Merino Benitez
24h 21m
2 stops
HOU9:46 pmHouston Hobby
$1,004
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momondo Fare Finder

 
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 10/9

6:20 am-3:35 am

2 stops19h 15m

Santiago Arturo Merino Benitez

Wed 10/22

3:30 pm-5:37 pm

3 stops28h 07m

$593

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Mon 9/15

6:59 pm-3:35 am

2 stops30h 36m

Santiago Arturo Merino Benitez

Mon 9/22

11:00 am-9:07 pm

1 stop36h 07m

$598

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Tue 11/11

7:00 am-3:35 am

2 stops17h 35m

Santiago Arturo Merino Benitez

Thu 11/13

11:25 pm-1:39 pm

1 stop17h 14m

$605

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Wed 10/22

2:48 pm-3:35 am

2 stops34h 47m

Santiago Arturo Merino Benitez

Wed 10/29

10:50 am-5:37 pm

1 stop32h 47m

$609

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 2/2

5:00 pm-2:05 pm

2 stops18h 05m

Santiago Arturo Merino Benitez

Tue 2/17

11:15 pm-9:32 am

1 stop13h 17m

$957

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Thu 10/9

10:13 am-7:00 am

1 stop18h 47m

Santiago Arturo Merino Benitez

Wed 10/22

2:20 pm-1:27 pm

2 stops25h 07m

$964

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Sat 2/14

5:35 pm-3:30 pm

2 stops18h 55m

Santiago Arturo Merino Benitez

Sun 3/1

12:25 am-9:46 pm

2 stops24h 21m

$997

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Fri 11/21

6:00 am-6:00 am

2 stops21h 00m

Santiago Arturo Merino Benitez

Sun 11/30

11:25 pm-9:40 pm

2 stops25h 15m

$1,048

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Thu 12/25

10:20 am-7:50 am

1 stop18h 30m

Santiago Arturo Merino Benitez

Mon 1/12

11:15 pm-11:27 am

1 stop15h 12m

$1,056

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 10/6

10:03 am-8:00 am

2 stops19h 57m

Santiago Arturo Merino Benitez

Mon 10/20

9:55 pm-4:09 pm

2 stops20h 14m

$1,093

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Houston to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Houston and Santiago?

What is the cheapest month to fly to Santiago?

In general, May is the cheapest month to fly from Houston to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $847. If you don’t want to visit Santiago in May, then you should wait until April to fly from Houston, when ticket prices are also cheap, with an average price of $1,018.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $1,037. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,557.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Houston to Santiago when you can find flight prices for as low as $981. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,498 per ticket.

What is the cheapest Houston to Santiago Arturo Merino Benitez flight route?

Fly from Houston George Bush Intcntl to Santiago Arturo Merino Benitez for the best Houston - Santiago Arturo Merino Benitez flight prices

What cabin class options are available on Houston to Santiago Arturo Merino Benitez flights?

There are 3 cabin classes available to choose from on Houston to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Houston to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Houston to Santiago

Fastest flight time

9h 05m

Direct flights

Every day

Airports in Santiago

1 airport
The fastest flight from Houston to Santiago takes 9h 05m
Direct flights go from Houston to Santiago every day.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
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  • How far is Houston to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Houston to Santiago Arturo Merino Benitez is 4652.9 mi. A reasonable flight in good conditions will take 12h 25m.

  • When did momondo last update prices for flights from Houston to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Houston to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Houston to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Houston to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Houston to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Houston to Santiago

Compare and see reviews for airlines that fly from Houston to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $499Free CancellationRating
6.7
2,415 reviews
Search Avianca flights
LATAM AirlinesPriceFrom $963Free CancellationRating
7.5
1,844 reviews
Search LATAM Airlines flights
United AirlinesPriceFrom $1,129Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights
American AirlinesPriceFrom $1,242Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Houston to Santiago?

It is quick and easy to find Houston to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Houston to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from Houston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Houston to Santiago?

Once you have performed a search for Houston to Santiago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Houston to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Houston to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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