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Cheap flights from Houston to Santiago from $250

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Houston to Santiago departing on 1/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Houston to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:08 am - 3:20 pm
IAH
-
SCL
49h 12m2 stops
Multiple Airlines Logo
11:25 pm - 11:59 pm
SCL
-
IAH
27h 34m1 stop
$583Multiple Airlines
lun., feb. 9 - lun., feb. 23
Multiple Airlines Logo
8:30 am - 5:35 am
IAH
-
SCL
18h 05m1 stop
Multiple Airlines Logo
9:05 pm - 3:08 pm
SCL
-
IAH
21h 03m2 stops
$611Multiple Airlines
mié., ene. 14 - lun., ene. 26
Multiple Airlines Logo
12:13 pm - 5:35 am
IAH
-
SCL
14h 22m1 stop
Multiple Airlines Logo
9:05 pm - 3:08 pm
SCL
-
IAH
21h 03m2 stops
$615Multiple Airlines
dom., ene. 18 - lun., ene. 26
Multiple Airlines Logo
12:13 pm - 5:35 am
IAH
-
SCL
14h 22m1 stop
Multiple Airlines Logo
6:30 pm - 1:10 pm
SCL
-
IAH
21h 40m2 stops
$619Multiple Airlines
dom., ene. 18 - mié., ene. 28
Delta Logo
5:45 am - 7:40 am
HOU
-
SCL
22h 55m1 stop
Delta Logo
11:10 pm - 12:20 pm
SCL
-
HOU
16h 10m1 stop
$964Delta
lun., feb. 9 - lun., feb. 23
LATAM Airlines Logo
5:35 pm - 5:30 pm
HOU
-
SCL
20h 55m2 stops
LATAM Airlines Logo
11:10 pm - 10:01 am
SCL
-
HOU
13h 51m1 stop
$996LATAM Airlines
sáb., feb. 14 - lun., mar. 2
Delta Logo
10:50 am - 3:30 pm
HOU
-
SCL
25h 40m2 stops
Delta Logo
11:10 pm - 12:20 pm
SCL
-
HOU
16h 10m1 stop
$1,004Delta
sáb., feb. 14 - lun., mar. 2
LATAM Airlines Logo
5:22 pm - 7:40 am
HOU
-
SCL
12h 18m1 stop
LATAM Airlines Logo
10:10 pm - 10:42 pm
SCL
-
HOU
26h 32m1 stop
$1,034LATAM Airlines
lun., mar. 9 - vie., mar. 20
American Airlines Logo
4:55 pm - 8:15 am
HOU
-
SCL
12h 20m1 stop
American Airlines Logo
10:00 pm - 11:47 am
SCL
-
HOU
16h 47m1 stop
$1,089American Airlines
jue., feb. 5 - jue., feb. 12
American Airlines Logo
12:47 pm - 9:00 am
HOU
-
SCL
17h 13m2 stops
American Airlines Logo
10:00 pm - 11:47 am
SCL
-
HOU
16h 47m1 stop
$1,094American Airlines
jue., feb. 5 - jue., feb. 12

Delta flights from Houston to Santiago

Our best Delta deals on Houston to Santiago flight tickets
Delta
Feb 9
HOU5:45 amHouston Hobby
22h 55m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Feb 23
SCL11:10 pmSantiago Arturo Merino Benitez
16h 10m
1 stop
HOU12:20 pmHouston Hobby
$964
Find similar
Delta
Feb 14
HOU10:50 amHouston Hobby
25h 40m
2 stops
SCL3:30 pmSantiago Arturo Merino Benitez
Mar 2
SCL11:10 pmSantiago Arturo Merino Benitez
16h 10m
1 stop
HOU12:20 pmHouston Hobby
$1,004
Find similar
Delta
Jan 18
HOU5:04 pmHouston Hobby
34h 06m
1 stop
SCL6:10 amSantiago Arturo Merino Benitez
Jan 26
SCL9:30 pmSantiago Arturo Merino Benitez
21h 40m
1 stop
HOU4:10 pmHouston Hobby
$1,225
Find similar

LATAM Airlines flights from Houston to Santiago

Our best LATAM Airlines deals on Houston to Santiago flight tickets
LATAM Airlines
Feb 14
HOU5:35 pmHouston Hobby
20h 55m
2 stops
SCL5:30 pmSantiago Arturo Merino Benitez
Mar 2
SCL11:10 pmSantiago Arturo Merino Benitez
13h 51m
1 stop
HOU10:01 amHouston Hobby
$996
Find similar
LATAM Airlines
Mar 9
HOU5:22 pmHouston Hobby
12h 18m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Mar 20
SCL10:10 pmSantiago Arturo Merino Benitez
26h 32m
1 stop
HOU10:42 pmHouston Hobby
$1,034
Find similar
LATAM Airlines
Feb 14
HOU5:35 pmHouston Hobby
35h 05m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Mar 2
SCL11:10 pmSantiago Arturo Merino Benitez
13h 51m
1 stop
HOU10:01 amHouston Hobby
$1,078
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 23, 2025.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

lun. 2/9

11:08 am-3:20 pm

2 stops49h 12m

Santiago Arturo Merino Benitez

lun. 2/23

11:25 pm-11:59 pm

1 stop27h 34m

$583

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

mié. 1/14

8:30 am-5:35 am

1 stop18h 05m

Santiago Arturo Merino Benitez

lun. 1/26

9:05 pm-3:08 pm

2 stops21h 03m

$611

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

dom. 1/18

12:13 pm-5:35 am

1 stop14h 22m

Santiago Arturo Merino Benitez

lun. 1/26

9:05 pm-3:08 pm

2 stops21h 03m

$615

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

dom. 1/18

12:13 pm-5:35 am

1 stop14h 22m

Santiago Arturo Merino Benitez

mié. 1/28

6:30 pm-1:10 pm

2 stops21h 40m

$619

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

lun. 2/9

5:45 am-7:40 am

1 stop22h 55m

Santiago Arturo Merino Benitez

lun. 2/23

11:10 pm-12:20 pm

1 stop16h 10m

$964

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

sáb. 2/14

5:35 pm-5:30 pm

2 stops20h 55m

Santiago Arturo Merino Benitez

lun. 3/2

11:10 pm-10:01 am

1 stop13h 51m

$996

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

sáb. 2/14

10:50 am-3:30 pm

2 stops25h 40m

Santiago Arturo Merino Benitez

lun. 3/2

11:10 pm-12:20 pm

1 stop16h 10m

$1,004

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

lun. 3/9

5:22 pm-7:40 am

1 stop12h 18m

Santiago Arturo Merino Benitez

vie. 3/20

10:10 pm-10:42 pm

1 stop26h 32m

$1,034

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

jue. 2/5

4:55 pm-8:15 am

1 stop12h 20m

Santiago Arturo Merino Benitez

jue. 2/12

10:00 pm-11:47 am

1 stop16h 47m

$1,089

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

jue. 2/5

12:47 pm-9:00 am

2 stops17h 13m

Santiago Arturo Merino Benitez

jue. 2/12

10:00 pm-11:47 am

1 stop16h 47m

$1,094

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Houston to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, April is the cheapest month to fly from Houston to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $720. If you don’t want to visit Santiago in April, then you should wait until May to fly from Houston, when ticket prices are also cheap, with an average price of $847.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $1,037. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,557.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Houston to Santiago when you can find flight prices for as low as $981. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,438 per ticket.

What is the cheapest Houston to Santiago Arturo Merino Benitez flight route?

Fly from Houston George Bush Intcntl to Santiago Arturo Merino Benitez for the best Houston - Santiago Arturo Merino Benitez flight prices

What cabin class options are available on Houston to Santiago Arturo Merino Benitez flights?

There are 3 cabin classes available to choose from on Houston to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Houston to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Houston to Santiago

Fastest flight time

9h 05m

Direct flights

Every day

Airports in Santiago

1 airport
The fastest flight from Houston to Santiago takes 9h 05m
Direct flights go from Houston to Santiago every day.
There is 1 airport in Santiago. From Houston there are direct flights to Santiago Arturo Merino Benitez (SCL).
Search flight deals

  • How far is Houston to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Houston to Santiago Arturo Merino Benitez is 4652.9 mi. A reasonable flight in good conditions will take 9h 05m.

  • When did momondo last update prices for flights from Houston to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Houston to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Houston to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Houston to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Houston to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Houston to Santiago

Compare and see reviews for airlines that fly from Houston to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $548Free CancellationRating
6.6
2,491 reviews
Search Avianca flights
LATAM AirlinesPriceFrom $949Free CancellationRating
7.5
1,894 reviews
Search LATAM Airlines flights
United AirlinesPriceFrom $949Free CancellationRating
7.4
9,106 reviews
Search United Airlines flights
DeltaPriceFrom $963Free CancellationRating
7.9
8,014 reviews
Search Delta flights
American AirlinesPriceFrom $964Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Houston to Santiago?

It is quick and easy to find Houston to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Houston to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from Houston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Houston to Santiago?

Once you have performed a search for Houston to Santiago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Houston to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Houston to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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