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Cheap flights from Houston to Santiago from $269

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Houston to Santiago departing on 3/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Houston to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:35 am - 1:45 pm
IAH
-
SCL
29h 10m2 stops
Multiple Airlines Logo
12:55 am - 11:49 pm
SCL
-
IAH
23h 54m3 stops
$605Multiple Airlines
Thu, Apr 9 - Mon, Apr 13
Multiple Airlines Logo
4:22 pm - 9:55 pm
IAH
-
SCL
50h 33m2 stops
Multiple Airlines Logo
10:35 am - 11:59 pm
SCL
-
IAH
15h 24m1 stop
$633Multiple Airlines
Thu, Feb 26 - Wed, Mar 11
Multiple Airlines Logo
5:15 am - 5:50 am
IAH
-
SCL
23h 35m3 stops
Multiple Airlines Logo
12:55 am - 11:49 pm
SCL
-
IAH
23h 54m3 stops
$636Multiple Airlines
Thu, Apr 9 - Mon, Apr 13
Multiple Airlines Logo
5:24 pm - 8:15 am
IAH
-
SCL
35h 51m2 stops
Multiple Airlines Logo
10:35 am - 10:36 am
SCL
-
IAH
26h 01m2 stops
$639Multiple Airlines
Thu, Mar 5 - Fri, Mar 13
Multiple Airlines Logo
5:05 am - 10:39 am
IAH
-
SCL
26h 34m3 stops
Multiple Airlines Logo
9:05 pm - 11:59 pm
SCL
-
IAH
29h 54m2 stops
$665Multiple Airlines
Fri, Feb 6 - Fri, Feb 13
Delta Logo
5:19 pm - 2:05 pm
HOU
-
SCL
17h 46m2 stops
Delta Logo
6:30 pm - 10:39 am
SCL
-
HOU
18h 09m2 stops
$958Delta
Thu, Feb 26 - Wed, Mar 11
Delta Logo
1:06 pm - 7:40 am
HOU
-
SCL
15h 34m1 stop
Delta Logo
6:30 pm - 10:39 am
SCL
-
HOU
18h 09m2 stops
$965Delta
Thu, Feb 26 - Wed, Mar 11
LATAM Airlines Logo
10:35 am - 6:00 am
HOU
-
SCL
18h 25m2 stops
LATAM Airlines Logo
8:40 pm - 9:20 am
SCL
-
HOU
13h 40m1 stop
$997LATAM Airlines
Fri, May 1 - Wed, May 13
LATAM Airlines Logo
1:45 pm - 6:55 am
HOU
-
SCL
16h 10m2 stops
LATAM Airlines Logo
6:45 pm - 12:10 pm
SCL
-
HOU
18h 25m2 stops
$1,002LATAM Airlines
Fri, May 1 - Wed, May 13
American Airlines Logo
12:18 pm - 8:05 am
HOU
-
SCL
16h 47m1 stop
American Airlines Logo
10:15 pm - 11:48 am
SCL
-
HOU
15h 33m1 stop
$1,010American Airlines
Mon, Mar 2 - Sun, Mar 15

American Airlines flights from Houston to Santiago

Our best American Airlines deals on Houston to Santiago flight tickets
American Airlines
Mar 2
HOU12:18 pmHouston Hobby
16h 47m
1 stop
SCL8:05 amSantiago Arturo Merino Benitez
Mar 15
SCL10:15 pmSantiago Arturo Merino Benitez
15h 33m
1 stop
HOU11:48 amHouston Hobby
$1,010
American Airlines
Mar 2
HOU12:18 pmHouston Hobby
18h 12m
2 stops
SCL9:30 amSantiago Arturo Merino Benitez
Mar 15
SCL10:15 pmSantiago Arturo Merino Benitez
13h 28m
1 stop
HOU9:43 amHouston Hobby
$1,140
American Airlines
Feb 7
HOU4:55 pmHouston Hobby
12h 20m
1 stop
SCL8:15 amSantiago Arturo Merino Benitez
Apr 11
SCL8:30 pmSantiago Arturo Merino Benitez
20h 19m
2 stops
HOU3:49 pmHouston Hobby
$1,175

LATAM Airlines flights from Houston to Santiago

Our best LATAM Airlines deals on Houston to Santiago flight tickets
LATAM Airlines
Mar 10
HOU11:44 amHouston Hobby
17h 56m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Mar 31
SCL8:40 pmSantiago Arturo Merino Benitez
15h 59m
1 stop
HOU10:39 amHouston Hobby
$1,032
LATAM Airlines
Apr 3
HOU5:27 pmHouston Hobby
12h 48m
1 stop
SCL8:15 amSantiago Arturo Merino Benitez
Apr 12
SCL8:40 pmSantiago Arturo Merino Benitez
27h 04m
1 stop
HOU10:44 pmHouston Hobby
$1,040
LATAM Airlines
Mar 8
HOU11:44 amHouston Hobby
17h 56m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Mar 21
SCL10:10 pmSantiago Arturo Merino Benitez
14h 29m
1 stop
HOU10:39 amHouston Hobby
$1,043

momondo Fare Finder

 
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 4/9

7:35 am-1:45 pm

2 stops29h 10m

Santiago Arturo Merino Benitez

Mon 4/13

12:55 am-11:49 pm

3 stops23h 54m

$605

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 2/26

4:22 pm-9:55 pm

2 stops50h 33m

Santiago Arturo Merino Benitez

Wed 3/11

10:35 am-11:59 pm

1 stop15h 24m

$633

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 4/9

5:15 am-5:50 am

3 stops23h 35m

Santiago Arturo Merino Benitez

Mon 4/13

12:55 am-11:49 pm

3 stops23h 54m

$636

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Thu 3/5

5:24 pm-8:15 am

2 stops35h 51m

Santiago Arturo Merino Benitez

Fri 3/13

10:35 am-10:36 am

2 stops26h 01m

$639

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Fri 2/6

5:05 am-10:39 am

3 stops26h 34m

Santiago Arturo Merino Benitez

Fri 2/13

9:05 pm-11:59 pm

2 stops29h 54m

$665

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Thu 2/26

5:19 pm-2:05 pm

2 stops17h 46m

Santiago Arturo Merino Benitez

Wed 3/11

6:30 pm-10:39 am

2 stops18h 09m

$958

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Thu 2/26

1:06 pm-7:40 am

1 stop15h 34m

Santiago Arturo Merino Benitez

Wed 3/11

6:30 pm-10:39 am

2 stops18h 09m

$965

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Fri 5/1

10:35 am-6:00 am

2 stops18h 25m

Santiago Arturo Merino Benitez

Wed 5/13

8:40 pm-9:20 am

1 stop13h 40m

$997

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Fri 5/1

1:45 pm-6:55 am

2 stops16h 10m

Santiago Arturo Merino Benitez

Wed 5/13

6:45 pm-12:10 pm

2 stops18h 25m

$1,002

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 3/2

12:18 pm-8:05 am

1 stop16h 47m

Santiago Arturo Merino Benitez

Sun 3/15

10:15 pm-11:48 am

1 stop15h 33m

$1,010

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Houston to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, April is the cheapest month to fly from Houston to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $720. If you don’t want to visit Santiago in April, then you should wait until May to fly from Houston, when ticket prices are also cheap, with an average price of $847.

What is the cheapest Houston to Santiago Arturo Merino Benitez flight route?

Fly from Houston George Bush Intcntl to Santiago Arturo Merino Benitez for the best Houston - Santiago Arturo Merino Benitez flight prices

What cabin class options are available on Houston to Santiago Arturo Merino Benitez flights?

There are 3 cabin classes available to choose from on Houston to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Houston to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Houston to Santiago

Fastest flight time

9h 05m

Direct flights

Every day

Airports in Santiago

1 airport
The fastest flight from Houston to Santiago takes 9h 05m
Direct flights go from Houston to Santiago every day.
There is 1 airport in Santiago. From Houston there are direct flights to Santiago Arturo Merino Benitez (SCL).
Search flight deals

  • How far is Houston to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Houston to Santiago Arturo Merino Benitez is 4652.9 mi. A reasonable flight in good conditions will take 9h 05m.

  • When did momondo last update prices for flights from Houston to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Houston to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Houston to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Houston to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Houston to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Houston to Santiago

Compare and see reviews for airlines that fly from Houston to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $548Free CancellationRating
6.6
2,492 reviews
Search Avianca flights
LATAM AirlinesPriceFrom $949Free CancellationRating
7.5
1,901 reviews
Search LATAM Airlines flights
United AirlinesPriceFrom $949Free CancellationRating
7.4
9,142 reviews
Search United Airlines flights
American AirlinesPriceFrom $964Free CancellationRating
7.2
11,097 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Houston to Santiago?

It is quick and easy to find Houston to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Houston to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from Houston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Houston to Santiago?

Once you have performed a search for Houston to Santiago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Houston to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Houston to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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