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Cheap flights from Houston to Santiago from $241

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Houston to Santiago departing on 10/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Multiple Airlines Logo
8:35 am - 12:20 pmIAH-SCL
25h 45m3 stops
Multiple Airlines Logo
12:30 pm - 9:17 pmSCL-IAH
34h 47m2 stops
$546Multiple Airlines
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Mon, Oct 13 - Mon, Oct 20
Multiple Airlines Logo
6:43 pm - 6:00 amIAH-SCL
33h 17m2 stops
Multiple Airlines Logo
5:55 am - 9:17 pmSCL-IAH
17h 22m2 stops
$556Multiple Airlines
Find Deal
Sun, Oct 12 - Fri, Oct 17
Multiple Airlines Logo
8:35 am - 10:15 pmIAH-SCL
35h 40m2 stops
Multiple Airlines Logo
9:15 pm - 9:17 pmSCL-IAH
26h 02m2 stops
$557Multiple Airlines
Find Deal
Mon, Oct 13 - Mon, Oct 20
Multiple Airlines Logo
8:35 am - 12:20 pmIAH-SCL
25h 45m3 stops
Multiple Airlines Logo
5:50 am - 9:17 pmSCL-IAH
17h 27m2 stops
$561Multiple Airlines
Find Deal
Mon, Oct 13 - Sat, Nov 1
LATAM Airlines Logo
2:22 pm - 7:40 amHOU-SCL
14h 18m1 stop
LATAM Airlines Logo
12:55 am - 5:58 pmSCL-HOU
20h 03m2 stops
$964LATAM Airlines
Find Deal
Mon, Nov 3 - Mon, Nov 24
Delta Logo
10:13 am - 6:00 amHOU-SCL
16h 47m2 stops
Delta Logo
12:55 am - 5:58 pmSCL-HOU
20h 03m2 stops
$968Delta
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Mon, Nov 3 - Mon, Nov 24
LATAM Airlines Logo
10:40 am - 9:35 pmHOU-SCL
31h 55m3 stops
LATAM Airlines Logo
8:50 pm - 11:46 pmSCL-HOU
29h 56m2 stops
$998LATAM Airlines
Find Deal
Sun, Nov 30 - Sun, Dec 14
Delta Logo
10:40 am - 12:50 pmHOU-SCL
23h 10m2 stops
Delta Logo
6:30 pm - 1:27 pmSCL-HOU
21h 57m2 stops
$1,044Delta
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Sun, Nov 30 - Sun, Dec 14
American Airlines Logo
2:26 pm - 7:30 amHOU-SCL
15h 04m1 stop
American Airlines Logo
10:25 pm - 11:44 amSCL-HOU
16h 19m2 stops
$1,093American Airlines
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Thu, Oct 30 - Thu, Nov 6
American Airlines Logo
2:26 pm - 8:55 amHOU-SCL
16h 29m2 stops
American Airlines Logo
10:25 pm - 11:44 amSCL-HOU
16h 19m2 stops
$1,099American Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6

American Airlines flights from Houston to Santiago

Our best American Airlines deals on Houston to Santiago flight tickets
American Airlines
Oct 30
HOU2:26 pmHouston Hobby
15h 04m
1 stop
SCL7:30 amSantiago Arturo Merino Benitez
Nov 6
SCL10:25 pmSantiago Arturo Merino Benitez
16h 19m
2 stops
HOU11:44 amHouston Hobby
$1,093
Find similar
American Airlines
Oct 30
HOU2:26 pmHouston Hobby
16h 29m
2 stops
SCL8:55 amSantiago Arturo Merino Benitez
Nov 6
SCL10:25 pmSantiago Arturo Merino Benitez
16h 19m
2 stops
HOU11:44 amHouston Hobby
$1,099
Find similar
American Airlines
Nov 21
HOU6:00 amHouston Hobby
23h 00m
1 stop
SCL8:00 amSantiago Arturo Merino Benitez
Nov 30
SCL11:15 pmSantiago Arturo Merino Benitez
13h 25m
1 stop
HOU9:40 amHouston Hobby
$1,150
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LATAM Airlines flights from Houston to Santiago

Our best LATAM Airlines deals on Houston to Santiago flight tickets
LATAM Airlines
Nov 3
HOU2:22 pmHouston Hobby
14h 18m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Nov 24
SCL12:55 amSantiago Arturo Merino Benitez
20h 03m
2 stops
HOU5:58 pmHouston Hobby
$964
Find similar
LATAM Airlines
Nov 30
HOU10:40 amHouston Hobby
31h 55m
3 stops
SCL9:35 pmSantiago Arturo Merino Benitez
Dec 14
SCL8:50 pmSantiago Arturo Merino Benitez
29h 56m
2 stops
HOU11:46 pmHouston Hobby
$998
Find similar
LATAM Airlines
Nov 30
HOU10:40 amHouston Hobby
18h 00m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Dec 14
SCL4:40 pmSantiago Arturo Merino Benitez
28h 12m
2 stops
HOU5:52 pmHouston Hobby
$1,004
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momondo Fare Finder

 
Customize your flight search to find flights from Houston to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Houston to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Mon 10/13

8:35 am-12:20 pm

3 stops25h 45m

Santiago Arturo Merino Benitez

Mon 10/20

12:30 pm-9:17 pm

2 stops34h 47m

$546

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Sun 10/12

6:43 pm-6:00 am

2 stops33h 17m

Santiago Arturo Merino Benitez

Fri 10/17

5:55 am-9:17 pm

2 stops17h 22m

$556

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Mon 10/13

8:35 am-10:15 pm

2 stops35h 40m

Santiago Arturo Merino Benitez

Mon 10/20

9:15 pm-9:17 pm

2 stops26h 02m

$557

HoustonSantiago

IAH - SCL

IAHSCL

Houston George Bush Intcntl

Mon 10/13

8:35 am-12:20 pm

3 stops25h 45m

Santiago Arturo Merino Benitez

Sat 11/1

5:50 am-9:17 pm

2 stops17h 27m

$561

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 11/3

2:22 pm-7:40 am

1 stop14h 18m

Santiago Arturo Merino Benitez

Mon 11/24

12:55 am-5:58 pm

2 stops20h 03m

$964

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Mon 11/3

10:13 am-6:00 am

2 stops16h 47m

Santiago Arturo Merino Benitez

Mon 11/24

12:55 am-5:58 pm

2 stops20h 03m

$968

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Sun 11/30

10:40 am-9:35 pm

3 stops31h 55m

Santiago Arturo Merino Benitez

Sun 12/14

8:50 pm-11:46 pm

2 stops29h 56m

$998

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Sun 11/30

10:40 am-12:50 pm

2 stops23h 10m

Santiago Arturo Merino Benitez

Sun 12/14

6:30 pm-1:27 pm

2 stops21h 57m

$1,044

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Thu 10/30

2:26 pm-7:30 am

1 stop15h 04m

Santiago Arturo Merino Benitez

Thu 11/6

10:25 pm-11:44 am

2 stops16h 19m

$1,093

HoustonSantiago

HOU - SCL

HOUSCL

Houston Hobby

Thu 10/30

2:26 pm-8:55 am

2 stops16h 29m

Santiago Arturo Merino Benitez

Thu 11/6

10:25 pm-11:44 am

2 stops16h 19m

$1,099

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Houston to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, May is the cheapest month to fly from Houston to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $847. If you don’t want to visit Santiago in May, then you should wait until April to fly from Houston, when ticket prices are also cheap, with an average price of $1,018.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $1,037. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,557.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Houston to Santiago when you can find flight prices for as low as $981. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,500 per ticket.

What is the cheapest Houston to Santiago Arturo Merino Benitez flight route?

Fly from Houston George Bush Intcntl to Santiago Arturo Merino Benitez for the best Houston - Santiago Arturo Merino Benitez flight prices

What cabin class options are available on Houston to Santiago Arturo Merino Benitez flights?

There are 3 cabin classes available to choose from on Houston to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Houston to Santiago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Houston to Santiago

Fastest flight time

9h 05m

Direct flights

Every day

Airports in Santiago

1 airport
The fastest flight from Houston to Santiago takes 9h 05m
Direct flights go from Houston to Santiago every day.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
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  • How far is Houston to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Houston to Santiago Arturo Merino Benitez is 4652.9 mi. A reasonable flight in good conditions will take 12h 38m.

  • When did momondo last update prices for flights from Houston to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Houston to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Houston to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Houston to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Houston to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Houston to Santiago

Compare and see reviews for airlines that fly from Houston to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AviancaPriceFrom $499Free CancellationRating
6.7
2,435 reviews
Search Avianca flights
DeltaPriceFrom $963Free CancellationRating
7.9
7,957 reviews
Search Delta flights
LATAM AirlinesPriceFrom $963Free CancellationRating
7.5
1,847 reviews
Search LATAM Airlines flights
United AirlinesPriceFrom $1,129Free CancellationRating
7.4
8,924 reviews
Search United Airlines flights
American AirlinesPriceFrom $1,242Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Houston to Santiago?

It is quick and easy to find Houston to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Houston to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from Houston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Houston to Santiago?

Once you have performed a search for Houston to Santiago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Houston to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Houston to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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