Cheap flights from Guayaquil to Santiago from $231

In general, November is the cheapest month to fly from Guayaquil to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $421. If you don’t want to visit Santiago in November, then you should wait until September to fly from Guayaquil, when ticket prices are also cheap, with an average price of $439.

The cheapest day to depart on your flight to Santiago is on a Friday when prices can be found for as low as $509. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Monday is $584.

At noon is the cheapest time of day to fly from Guayaquil to Santiago when you can find flight prices for as low as $516. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $547 per ticket.

Fly from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez for the best Guayaquil Jose Joaquin de Olmedo - Santiago Arturo Merino Benitez flight prices

You are more likely to see cheaper flights to Santiago from Guayaquil when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $467 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Guayaquil for as low as $409 on momondo.

You could potentially save up to 40% on your flight if you consider stops on a Guayaquil to Santiago flight.

As of May 2026, prices for Guayaquil to Santiago flights are approximately 24% more expensive when compared to flights at the same time last year.

Avianca, LATAM Airlines, and Copa Airlines are the most popular carriers operating from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez

LATAM Airlines, Avianca and Copa Airlines are the top three most popular airlines that fly to Santiago from Guayaquil according to our data. LATAM Airlines is the first choice among our users, with 81% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Historically, on average around 8% of flights between Guayaquil and Santiago have experienced a delay on any given week. The average delay length over the past 12 months has been 122 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Friday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the least number of delays on this route over the last 12 months; with about 8% of their flights experiencing any sort of delay.