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Cheap flights from Guayaquil to Santiago from $214

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Guayaquil to Santiago departing on 10/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Guayaquil to Santiago (GYE-SCL)

Cheap round-trip flights

Avianca Logo
3:35 am - 2:25 pmGYE-SCL
8h 50m1 stop
Avianca Logo
7:10 am - 5:20 pmSCL-GYE
12h 10m1 stop
$310Avianca
Find Deal
Sat, Oct 11 - Sun, Oct 19
Avianca Logo
6:25 pm - 5:15 amGYE-SCL
8h 50m1 stop
Avianca Logo
3:30 pm - 10:40 pmSCL-GYE
9h 10m1 stop
$311Avianca
Find Deal
Mon, Oct 13 - Tue, Oct 21
Logo
3:35 am - 2:25 pmGYE-SCL
8h 50m1 stop
Logo
6:40 am - 11:55 amSCL-GYE
7h 15m1 stop
$317
Find Deal
Mon, Oct 13 - Tue, Oct 28
Logo
3:35 am - 11:30 pmGYE-SCL
17h 55m1 stop
Logo
11:50 pm - 3:13 amSCL-GYE
5h 23mnonstop
$318
Find Deal
Wed, Oct 8 - Wed, Oct 15
Logo
3:35 pm - 3:20 pmGYE-SCL
21h 45m1 stop
Logo
7:59 pm - 11:55 amSCL-GYE
17h 56m2 stops
$325
Find Deal
Wed, Nov 5 - Mon, Nov 10
Logo
3:35 am - 2:25 pmGYE-SCL
8h 50m1 stop
Logo
11:50 pm - 3:13 amSCL-GYE
5h 23mnonstop
$329
Find Deal
Wed, Oct 15 - Tue, Oct 21
Logo
3:35 am - 2:25 pmGYE-SCL
8h 50m1 stop
Logo
11:50 pm - 3:13 amSCL-GYE
5h 23mnonstop
$330
Find Deal
Wed, Oct 15 - Wed, Oct 22
Avianca Logo
3:35 am - 2:25 pmGYE-SCL
8h 50m1 stop
Avianca Logo
12:55 am - 11:25 amSCL-GYE
12h 30m2 stops
$331Avianca
Find Deal
Sun, Oct 12 - Mon, Oct 20
Avianca Logo
6:25 pm - 5:15 amGYE-SCL
8h 50m1 stop
Avianca Logo
12:55 am - 8:35 amSCL-GYE
9h 40m1 stop
$333Avianca
Find Deal
Fri, Oct 10 - Wed, Oct 15
Copa Airlines Logo
2:35 pm - 3:43 amGYE-SCL
11h 08m1 stop
Copa Airlines Logo
5:44 am - 1:34 pmSCL-GYE
9h 50m1 stop
$397Copa Airlines
Find Deal
Tue, Nov 11 - Fri, Feb 13

Avianca flights from Guayaquil to Santiago

Our best Avianca deals on Guayaquil to Santiago flight tickets
Avianca
Oct 11
GYE3:35 amGuayaquil Jose Joaquin de Olmedo
8h 50m
1 stop
SCL2:25 pmSantiago Arturo Merino Benitez
Oct 19
SCL7:10 amSantiago Arturo Merino Benitez
12h 10m
1 stop
GYE5:20 pmGuayaquil Jose Joaquin de Olmedo
$310
Find similar
Avianca
Oct 13
GYE6:25 pmGuayaquil Jose Joaquin de Olmedo
8h 50m
1 stop
SCL5:15 amSantiago Arturo Merino Benitez
Oct 21
SCL3:30 pmSantiago Arturo Merino Benitez
9h 10m
1 stop
GYE10:40 pmGuayaquil Jose Joaquin de Olmedo
$311
Find similar
Avianca
Oct 12
GYE3:35 amGuayaquil Jose Joaquin de Olmedo
8h 50m
1 stop
SCL2:25 pmSantiago Arturo Merino Benitez
Oct 20
SCL12:55 amSantiago Arturo Merino Benitez
12h 30m
2 stops
GYE11:25 amGuayaquil Jose Joaquin de Olmedo
$331
Find similar

Copa Airlines flights from Guayaquil to Santiago

Our best Copa Airlines deals on Guayaquil to Santiago flight tickets
Copa Airlines
Nov 11
GYE2:35 pmGuayaquil Jose Joaquin de Olmedo
11h 08m
1 stop
SCL3:43 amSantiago Arturo Merino Benitez
Feb 13
SCL5:44 amSantiago Arturo Merino Benitez
9h 50m
1 stop
GYE1:34 pmGuayaquil Jose Joaquin de Olmedo
$397
Find similar
Copa Airlines
Aug 29
GYE4:27 amGuayaquil Jose Joaquin de Olmedo
17h 41m
1 stop
SCL11:08 pmSantiago Arturo Merino Benitez
Sep 1
SCL2:26 amSantiago Arturo Merino Benitez
12h 20m
1 stop
GYE1:46 pmGuayaquil Jose Joaquin de Olmedo
$565
Find similar
Copa Airlines
Aug 29
GYE12:17 pmGuayaquil Jose Joaquin de Olmedo
9h 27m
1 stop
SCL10:44 pmSantiago Arturo Merino Benitez
Sep 4
SCL2:26 amSantiago Arturo Merino Benitez
9h 49m
1 stop
GYE11:15 amGuayaquil Jose Joaquin de Olmedo
$570
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Guayaquil to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 28, 2025.
Use the filters below to find and compare flights from Guayaquil to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sat 10/11

3:35 am-2:25 pm

1 stop8h 50m

Santiago Arturo Merino Benitez

Sun 10/19

7:10 am-5:20 pm

1 stop12h 10m

$310

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 10/13

6:25 pm-5:15 am

1 stop8h 50m

Santiago Arturo Merino Benitez

Tue 10/21

3:30 pm-10:40 pm

1 stop9h 10m

$311

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Mon 10/13

3:35 am-2:25 pm

1 stop8h 50m

Santiago Arturo Merino Benitez

Tue 10/28

6:40 am-11:55 am

1 stop7h 15m

$317

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 10/8

3:35 am-11:30 pm

1 stop17h 55m

Santiago Arturo Merino Benitez

Wed 10/15

11:50 pm-3:13 am

Nonstop5h 23m

$318

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 11/5

3:35 pm-3:20 pm

1 stop21h 45m

Santiago Arturo Merino Benitez

Mon 11/10

7:59 pm-11:55 am

2 stops17h 56m

$325

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 10/15

3:35 am-2:25 pm

1 stop8h 50m

Santiago Arturo Merino Benitez

Tue 10/21

11:50 pm-3:13 am

Nonstop5h 23m

$329

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 10/15

3:35 am-2:25 pm

1 stop8h 50m

Santiago Arturo Merino Benitez

Wed 10/22

11:50 pm-3:13 am

Nonstop5h 23m

$330

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sun 10/12

3:35 am-2:25 pm

1 stop8h 50m

Santiago Arturo Merino Benitez

Mon 10/20

12:55 am-11:25 am

2 stops12h 30m

$331

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Fri 10/10

6:25 pm-5:15 am

1 stop8h 50m

Santiago Arturo Merino Benitez

Wed 10/15

12:55 am-8:35 am

1 stop9h 40m

$333

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Tue 11/11

2:35 pm-3:43 am

1 stop11h 08m

Santiago Arturo Merino Benitez

Fri 2/13

5:44 am-1:34 pm

1 stop9h 50m

$397

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Santiago from

How to get the cheapest flight ticket from Guayaquil to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Guayaquil and Santiago?

What is the cheapest month to fly to Santiago?

In general, November is the cheapest month to fly from Guayaquil to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $373. If you don’t want to visit Santiago in November, then you should wait until October to fly from Guayaquil, when ticket prices are also cheap, with an average price of $382.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Thursday when prices can be found for as low as $487. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $600.

What is the cheapest time of day to depart on your flight to Santiago?

In the morning is the cheapest time of day to fly from Guayaquil to Santiago when you can find flight prices for as low as $376. Flying to Santiago in the morning is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $546 per ticket.

What is the cheapest Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez flight route?

Fly from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez for the best Guayaquil Jose Joaquin de Olmedo - Santiago Arturo Merino Benitez flight prices

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Guayaquil when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $410 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Guayaquil for as low as $359 on momondo.

What cabin class options are available on Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez flights?

There are 2 cabin classes available to choose from on Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Guayaquil to Santiago flights?

You could potentially save up to 17% on your flight if you consider stops on a Guayaquil to Santiago flight.

How have Guayaquil to Santiago flight prices changed over time?

As of August 2025, prices for Guayaquil to Santiago flights are approximately 18% cheaper when compared to flights at the same time last year.

When to book flights from Guayaquil to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Guayaquil to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Guayaquil to Santiago (GYE to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Guayaquil to Santiago

Best Price Found

$302

Fastest flight time

4h 47m

Direct flights

Every day

Airports in Santiago

1 airport
The best one-way flight to Santiago from Guayaquil in the past 72 hours is $302. The best round-trip flight deal from Guayaquil to Santiago found on momondo in the last 72 hours is $416.
The fastest flight from Guayaquil to Santiago takes 4h 47m
Direct flights go from Guayaquil to Santiago every day.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
Search flight deals

  • How far is Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez by plane?

    Santiago Arturo Merino Benitez is 2238.9 mi away from Guayaquil Jose Joaquin de Olmedo. A reasonable flight in good conditions will take 4h 53m.

  • When did momondo last update prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Guayaquil Jose Joaquin de Olmedo Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Guayaquil Jose Joaquin de Olmedo Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Guayaquil Jose Joaquin de Olmedo Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Guayaquil to Santiago?

  • What is the most popular airline from Guayaquil to Santiago?

Best airlines flying from Guayaquil to Santiago

Compare and see reviews for airlines that fly from Guayaquil to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $178Free CancellationRating
7.5
1,517 reviews
Search Copa Airlines flights
AviancaPriceFrom $191Free CancellationRating
6.7
2,420 reviews
Search Avianca flights
LATAM AirlinesPriceFrom $254Free CancellationRating
7.5
1,842 reviews
Search LATAM Airlines flights

  • LATAM Airlines Flights From Guayaquil to Santiago

    LATAM Airlines flight deals from Guayaquil to Santiago start from $254 round-trip. Over the 4 LATAM Airlines flights for this route in a normal week, average airfare is usually $496 round-trip - but some users have found much cheaper deals with momondo.

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Guayaquil to Santiago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Guayaquil to Santiago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Guayaquil to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from Guayaquil which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Guayaquil to Santiago?

momondo helps you find the best flight between Guayaquil and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Guayaquil to Santiago right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santiago, momondo offers a useful price alert feature which will track prices for flights to Santiago from Guayaquil and alert you when they change.

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