Cheap flights from Guayaquil to Santiago from $231

In general, September is the cheapest month to fly from Guayaquil to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $414. If you don’t want to visit Santiago in September, then you should wait until November to fly from Guayaquil, when ticket prices are also cheap, with an average price of $433.

The cheapest day to depart on your flight to Santiago is on a Sunday when prices can be found for as low as $472. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Wednesday is $577.

In the afternoon is the cheapest time of day to fly from Guayaquil to Santiago when you can find flight prices for as low as $530. Flying to Santiago in the afternoon is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Santiago, so prices are often more expensive at around $585 per ticket.

Fly from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez for the best Guayaquil Jose Joaquin de Olmedo - Santiago Arturo Merino Benitez flight prices

You are more likely to see cheaper flights to Santiago from Guayaquil when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $465 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Guayaquil for as low as $432 on momondo.

There are 2 cabin classes available to choose from on Guayaquil to Santiago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Guayaquil to Santiago.

As of November 2026, prices for Guayaquil to Santiago flights are approximately 15% more expensive when compared to flights at the same time last year.

LATAM Airlines and Copa Airlines are the most popular carriers operating from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez

LATAM Airlines, Avianca and Copa Airlines are the top three most popular airlines that fly to Santiago from Guayaquil according to our data. LATAM Airlines is the first choice among our users, with 75% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 3 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Historically, on average around 9% of flights between Guayaquil and Santiago have experienced a delay on any given week. The average delay length over the past 12 months has been 125 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Monday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the least number of delays on this route over the last 12 months; with about 9% of their flights experiencing any sort of delay.