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Cheap flights from Greenville to Santo Domingo from $180

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Santo Domingo departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Greenville to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:48 am - 2:27 pm
GSP
-
SDQ
27h 39m1 stop
Multiple Airlines Logo
3:32 pm - 4:55 pm
SDQ
-
GSP
26h 23m1 stop
$366Multiple Airlines
Fri, Jan 23 - Wed, Jan 28
Multiple Airlines Logo
4:39 pm - 2:27 pm
GSP
-
SDQ
20h 48m2 stops
Multiple Airlines Logo
3:32 pm - 4:55 pm
SDQ
-
GSP
26h 23m1 stop
$384Multiple Airlines
Fri, Jan 23 - Wed, Jan 28
Delta Logo
6:50 am - 2:21 pm
GSP
-
SDQ
6h 31m1 stop
Delta Logo
3:46 pm - 9:52 pm
SDQ
-
GSP
7h 06m1 stop
$468Delta
Wed, Jan 21 - Thu, Jan 29
Delta Logo
5:40 am - 7:14 pm
GSP
-
SDQ
12h 34m2 stops
Delta Logo
3:46 pm - 9:52 pm
SDQ
-
GSP
7h 06m1 stop
$472Delta
Wed, Jan 21 - Thu, Jan 29
Delta Logo
5:40 am - 2:21 pm
GSP
-
SDQ
7h 41m1 stop
Delta Logo
3:46 pm - 11:50 pm
SDQ
-
GSP
9h 04m1 stop
$478Delta
Wed, Feb 4 - Mon, Feb 9
Delta Logo
5:40 am - 7:14 pm
GSP
-
SDQ
12h 34m2 stops
Delta Logo
3:46 pm - 11:50 pm
SDQ
-
GSP
9h 04m1 stop
$482Delta
Wed, Feb 4 - Mon, Feb 9
American Airlines Logo
7:12 pm - 9:00 am
GSP
-
SDQ
13h 48m1 stop
American Airlines Logo
10:00 am - 6:42 pm
SDQ
-
GSP
8h 42m1 stop
$483American Airlines
Sun, Mar 29 - Sun, Apr 5
American Airlines Logo
7:56 pm - 10:50 am
GSP
-
SDQ
14h 54m1 stop
American Airlines Logo
5:00 pm - 10:59 pm
SDQ
-
GSP
5h 59m1 stop
$518American Airlines
Mon, Jun 1 - Sat, Jun 6
Multiple Airlines Logo
2:57 pm - 9:41 am
GSP
-
SDQ
18h 44m1 stop
Multiple Airlines Logo
3:39 pm - 3:27 pm
SDQ
-
GSP
23h 48m2 stops
$550Multiple Airlines
Sun, Mar 29 - Sun, Apr 5
American Airlines Logo
7:56 pm - 10:50 am
GSP
-
SDQ
14h 54m1 stop
American Airlines Logo
6:30 pm - 10:05 am
SDQ
-
GSP
15h 35m2 stops
$572American Airlines
Mon, Jun 1 - Sat, Jun 6

Delta flights from Greenville to Santo Domingo

Our best Delta deals on Greenville to Santo Domingo flight tickets
Delta
Feb 4
GSP5:40 amGreenville
7h 41m
1 stop
SDQ2:21 pmSanto Domingo Las Americas
Feb 9
SDQ3:46 pmSanto Domingo Las Americas
9h 04m
1 stop
GSP11:50 pmGreenville
$478
Find similar
Delta
Feb 4
GSP5:40 amGreenville
12h 34m
2 stops
SDQ7:14 pmSanto Domingo Las Americas
Feb 9
SDQ3:46 pmSanto Domingo Las Americas
9h 04m
1 stop
GSP11:50 pmGreenville
$482
Find similar
Delta
Dec 25
GSP7:30 amGreenville
9h 53m
2 stops
SDQ6:23 pmSanto Domingo Las Americas
Jan 5
SDQ8:45 pmSanto Domingo Las Americas
15h 23m
2 stops
GSP11:08 amGreenville
$1,572
Find similar

American Airlines flights from Greenville to Santo Domingo

Our best American Airlines deals on Greenville to Santo Domingo flight tickets
American Airlines
Mar 29
GSP7:12 pmGreenville
13h 48m
1 stop
SDQ9:00 amSanto Domingo Las Americas
Apr 5
SDQ10:00 amSanto Domingo Las Americas
8h 42m
1 stop
GSP6:42 pmGreenville
$483
Find similar
American Airlines
Apr 5
GSP7:12 pmGreenville
13h 48m
1 stop
SDQ9:00 amSanto Domingo Las Americas
Apr 10
SDQ7:55 amSanto Domingo Las Americas
15h 08m
1 stop
GSP11:03 pmGreenville
$678
Find similar
American Airlines
Apr 5
GSP6:24 pmGreenville
14h 36m
2 stops
SDQ9:00 amSanto Domingo Las Americas
Apr 10
SDQ7:55 amSanto Domingo Las Americas
10h 16m
1 stop
GSP6:11 pmGreenville
$682
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Greenville to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Fri 1/23

9:48 am-2:27 pm

1 stop27h 39m

Santo Domingo Las Americas

Wed 1/28

3:32 pm-4:55 pm

1 stop26h 23m

$366

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Fri 1/23

4:39 pm-2:27 pm

2 stops20h 48m

Santo Domingo Las Americas

Wed 1/28

3:32 pm-4:55 pm

1 stop26h 23m

$384

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 1/21

6:50 am-2:21 pm

1 stop6h 31m

Santo Domingo Las Americas

Thu 1/29

3:46 pm-9:52 pm

1 stop7h 06m

$468

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 1/21

5:40 am-7:14 pm

2 stops12h 34m

Santo Domingo Las Americas

Thu 1/29

3:46 pm-9:52 pm

1 stop7h 06m

$472

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 2/4

5:40 am-2:21 pm

1 stop7h 41m

Santo Domingo Las Americas

Mon 2/9

3:46 pm-11:50 pm

1 stop9h 04m

$478

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 2/4

5:40 am-7:14 pm

2 stops12h 34m

Santo Domingo Las Americas

Mon 2/9

3:46 pm-11:50 pm

1 stop9h 04m

$482

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sun 3/29

7:12 pm-9:00 am

1 stop13h 48m

Santo Domingo Las Americas

Sun 4/5

10:00 am-6:42 pm

1 stop8h 42m

$483

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Mon 6/1

7:56 pm-10:50 am

1 stop14h 54m

Santo Domingo Las Americas

Sat 6/6

5:00 pm-10:59 pm

1 stop5h 59m

$518

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sun 3/29

2:57 pm-9:41 am

1 stop18h 44m

Santo Domingo Las Americas

Sun 4/5

3:39 pm-3:27 pm

2 stops23h 48m

$550

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Mon 6/1

7:56 pm-10:50 am

1 stop14h 54m

Santo Domingo Las Americas

Sat 6/6

6:30 pm-10:05 am

2 stops15h 35m

$572

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Greenville to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Greenville and Santo Domingo?

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in May, then you should wait until October to fly from Greenville, when ticket prices are also cheap, with an average price of $504.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Thursday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $623. The most expensive day to fly to Santo Domingo is Saturday, with ticket prices averaging around $803.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the evening when flights can be purchased for as low as $683. Try not to purchase tickets in the morning because they tend to be around $714. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Greenville to Santo Domingo flights?

You could potentially save up to 5% on your flight if you consider stops on a Greenville to Santo Domingo flight.

When to book flights from Greenville to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to Santo Domingo (GSP to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Santo Domingo

Fastest flight time

7h 17m

Direct flights

None
The fastest flight from Greenville to Santo Domingo takes 7h 17m
There are no direct flights from Greenville to Santo Domingo. There are no popular flight routes from Greenville to Santo Domingo.
Search flight deals

  • How far is Greenville to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 1364.2 mi away from Greenville. Flights usually cover this in 7h 17m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Greenville Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Greenville Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from Greenville Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Greenville Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Greenville Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents you'll need for your trip to Santo Domingo Las Americas Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santo Domingo Las Americas Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to Santo Domingo?

Best airlines flying from Greenville to Santo Domingo

Compare and see reviews for airlines that fly from Greenville to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $484Free CancellationRating
7.9
8,005 reviews
Search Delta flights
American AirlinesPriceFrom $511Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Santo Domingo?

It is quick and easy to find Greenville to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Greenville to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from Greenville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Greenville to Santo Domingo?

momondo helps you find the best flight between Greenville and Santo Domingo by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Greenville to Santo Domingo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santo Domingo from Greenville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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