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Cheap flights from Greenville to Santo Domingo from $424

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Santo Domingo departing on 3/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Greenville to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:45 pm - 1:38 am
GSP
-
SDQ
6h 53m
1 stop
Multiple Airlines Logo
2:52 am - 5:43 pm
SDQ
-
GSP
14h 51m
1 stop
$424Multiple Airlines
Fri, Mar 27 - Thu, Apr 2
Multiple Airlines Logo
8:18 pm - 1:15 pm
GSP
-
SDQ
16h 57m
2 stops
Multiple Airlines Logo
2:52 am - 5:43 pm
SDQ
-
GSP
14h 51m
1 stop
$455Multiple Airlines
Fri, Mar 27 - Thu, Apr 2
American Airlines Logo
7:26 pm - 9:00 am
GSP
-
SDQ
13h 34m
1 stop
American Airlines Logo
4:03 pm - 12:21 am
SDQ
-
GSP
8h 18m
1 stop
$489American Airlines
Tue, Mar 24 - Tue, Mar 31
Delta Logo
5:40 am - 6:55 pm
GSP
-
SDQ
13h 15m
2 stops
Delta Logo
2:37 pm - 11:54 pm
SDQ
-
GSP
9h 17m
1 stop
$493Delta
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
12:55 pm - 10:53 pm
GSP
-
SDQ
9h 58m
2 stops
American Airlines Logo
5:50 pm - 12:21 am
SDQ
-
GSP
6h 31m
1 stop
$558American Airlines
Wed, Mar 11 - Fri, Mar 20
Delta Logo
6:49 am - 2:17 pm
GSP
-
SDQ
6h 28m
1 stop
Delta Logo
3:42 pm - 11:43 pm
SDQ
-
GSP
9h 01m
1 stop
$559Delta
Wed, Feb 18 - Wed, Feb 25
Delta Logo
6:49 am - 7:14 pm
GSP
-
SDQ
11h 25m
2 stops
Delta Logo
3:42 pm - 11:43 pm
SDQ
-
GSP
9h 01m
1 stop
$563Delta
Wed, Feb 18 - Wed, Feb 25
American Airlines Logo
7:51 am - 9:58 pm
GSP
-
SDQ
14h 07m
1 stop
American Airlines Logo
2:19 pm - 11:57 pm
SDQ
-
GSP
9h 38m
1 stop
$574American Airlines
Thu, Jun 25 - Tue, Jul 7
American Airlines Logo
5:20 am - 5:50 pm
GSP
-
SDQ
11h 30m
2 stops
American Airlines Logo
11:01 am - 10:08 pm
SDQ
-
GSP
12h 07m
2 stops
$593American Airlines
Sun, Feb 22 - Fri, Feb 27
American Airlines Logo
8:08 pm - 9:21 am
GSP
-
SDQ
13h 13m
1 stop
American Airlines Logo
4:26 pm - 11:57 pm
SDQ
-
GSP
7h 31m
1 stop
$594American Airlines
Sat, Jun 20 - Fri, Jun 26

American Airlines flights from Greenville to Santo Domingo

Our best American Airlines deals on Greenville to Santo Domingo flight tickets
American Airlines
Mar 24
GSP7:26 pmGreenville
13h 34m
1 stop
SDQ9:00 amSanto Domingo Las Americas
Mar 31
SDQ4:03 pmSanto Domingo Las Americas
8h 18m
1 stop
GSP12:21 amGreenville
$489
American Airlines
Mar 11
GSP12:55 pmGreenville
9h 58m
2 stops
SDQ10:53 pmSanto Domingo Las Americas
Mar 20
SDQ5:50 pmSanto Domingo Las Americas
6h 31m
1 stop
GSP12:21 amGreenville
$558
American Airlines
Jun 25
GSP7:51 amGreenville
14h 07m
1 stop
SDQ9:58 pmSanto Domingo Las Americas
Jul 7
SDQ2:19 pmSanto Domingo Las Americas
9h 38m
1 stop
GSP11:57 pmGreenville
$574

Delta flights from Greenville to Santo Domingo

Our best Delta deals on Greenville to Santo Domingo flight tickets
Delta
Mar 24
GSP5:40 amGreenville
13h 15m
2 stops
SDQ6:55 pmSanto Domingo Las Americas
Mar 31
SDQ2:37 pmSanto Domingo Las Americas
9h 17m
1 stop
GSP11:54 pmGreenville
$493
Delta
Feb 18
GSP6:49 amGreenville
6h 28m
1 stop
SDQ2:17 pmSanto Domingo Las Americas
Feb 25
SDQ3:42 pmSanto Domingo Las Americas
9h 01m
1 stop
GSP11:43 pmGreenville
$559
Delta
Feb 18
GSP6:49 amGreenville
11h 25m
2 stops
SDQ7:14 pmSanto Domingo Las Americas
Feb 25
SDQ3:42 pmSanto Domingo Las Americas
9h 01m
1 stop
GSP11:43 pmGreenville
$563

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from Greenville to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Fri 3/27

6:45 pm-1:38 am

1 stop6h 53m

Santo Domingo Las Americas

Thu 4/2

2:52 am-5:43 pm

1 stop14h 51m

$424

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Fri 3/27

8:18 pm-1:15 pm

2 stops16h 57m

Santo Domingo Las Americas

Thu 4/2

2:52 am-5:43 pm

1 stop14h 51m

$455

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Tue 3/24

7:26 pm-9:00 am

1 stop13h 34m

Santo Domingo Las Americas

Tue 3/31

4:03 pm-12:21 am

1 stop8h 18m

$489

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Tue 3/24

5:40 am-6:55 pm

2 stops13h 15m

Santo Domingo Las Americas

Tue 3/31

2:37 pm-11:54 pm

1 stop9h 17m

$493

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 3/11

12:55 pm-10:53 pm

2 stops9h 58m

Santo Domingo Las Americas

Fri 3/20

5:50 pm-12:21 am

1 stop6h 31m

$558

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 2/18

6:49 am-2:17 pm

1 stop6h 28m

Santo Domingo Las Americas

Wed 2/25

3:42 pm-11:43 pm

1 stop9h 01m

$559

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 2/18

6:49 am-7:14 pm

2 stops11h 25m

Santo Domingo Las Americas

Wed 2/25

3:42 pm-11:43 pm

1 stop9h 01m

$563

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Thu 6/25

7:51 am-9:58 pm

1 stop14h 07m

Santo Domingo Las Americas

Tue 7/7

2:19 pm-11:57 pm

1 stop9h 38m

$574

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sun 2/22

5:20 am-5:50 pm

2 stops11h 30m

Santo Domingo Las Americas

Fri 2/27

11:01 am-10:08 pm

2 stops12h 07m

$593

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sat 6/20

8:08 pm-9:21 am

1 stop13h 13m

Santo Domingo Las Americas

Fri 6/26

4:26 pm-11:57 pm

1 stop7h 31m

$594

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Greenville to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in May, then you should wait until October to fly from Greenville, when ticket prices are also cheap, with an average price of $504.

Can stopping save me money on Greenville to Santo Domingo flights?

You could potentially save up to 5% on your flight if you consider stops on a Greenville to Santo Domingo flight.

When to book flights from Greenville to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to Santo Domingo (GSP to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Santo Domingo

Fastest flight time

6h 28m

Direct flights

None
The fastest flight from Greenville to Santo Domingo takes 6h 28m
There are no direct flights from Greenville to Santo Domingo. There are no popular flight routes from Greenville to Santo Domingo.
Search flight deals

  • How far is Greenville to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 1364.2 mi away from Greenville. Flights usually cover this in 6h 28m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Greenville Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Greenville Airport to Santo Domingo Las Americas Airport were last updated today.

  • How many operators does momondo search for flights from Greenville Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Greenville Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Greenville Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents you'll need for your trip to Santo Domingo Las Americas Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santo Domingo Las Americas Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to Santo Domingo?

Best airlines flying from Greenville to Santo Domingo

Compare and see reviews for airlines that fly from Greenville to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $484Free CancellationRating
7.9
8,174 reviews
Search Delta flights
American AirlinesPriceFrom $499Free CancellationRating
7.2
11,258 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Santo Domingo?

It is quick and easy to find Greenville to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Greenville to Santo Domingo with flexible booking policies on momondo?

Yes. All flights to Santo Domingo from Greenville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Greenville to Santo Domingo?

momondo helps you find the best flight between Greenville and Santo Domingo by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Greenville to Santo Domingo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santo Domingo from Greenville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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