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Cheap flights from Greenville to Panama City from $341

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Panama City departing on 10/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Delta Logo
5:30 am - 12:56 pmGSP-PTY
8h 26m1 stop
Delta Logo
2:21 pm - 11:54 pmPTY-GSP
8h 33m1 stop
$341Delta
Find Deal
Tue, Oct 7 - Tue, Oct 14
American Airlines Logo
6:00 am - 2:00 pmGSP-PTY
9h 00m1 stop
American Airlines Logo
3:15 pm - 11:40 amPTY-GSP
19h 25m2 stops
$346American Airlines
Find Deal
Tue, Oct 7 - Tue, Oct 14
American Airlines Logo
6:24 pm - 2:00 pmGSP-PTY
20h 36m2 stops
American Airlines Logo
3:15 pm - 3:58 pmPTY-GSP
23h 43m1 stop
$354American Airlines
Find Deal
Sat, Oct 11 - Sat, Oct 25
American Airlines Logo
4:46 pm - 2:00 pmGSP-PTY
22h 14m1 stop
American Airlines Logo
3:15 pm - 3:58 pmPTY-GSP
23h 43m1 stop
$357American Airlines
Find Deal
Sat, Oct 11 - Sat, Oct 25
Delta Logo
6:45 am - 2:02 pmGSP-PTY
7h 17m1 stop
Delta Logo
3:27 pm - 11:36 pmPTY-GSP
8h 09m1 stop
$391Delta
Find Deal
Wed, Jan 21 - Wed, Feb 4
American Airlines Logo
6:45 pm - 2:30 pmGSP-PTY
20h 45m2 stops
American Airlines Logo
3:31 pm - 10:55 amPTY-GSP
18h 24m2 stops
$396American Airlines
Find Deal
Thu, Aug 28 - Thu, Sep 4
American Airlines Logo
6:05 pm - 2:30 pmGSP-PTY
21h 25m1 stop
American Airlines Logo
3:31 pm - 11:56 pmPTY-GSP
7h 25m1 stop
$400American Airlines
Find Deal
Thu, Aug 28 - Thu, Sep 4
American Airlines Logo
4:51 pm - 3:35 pmGSP-PTY
22h 44m1 stop
American Airlines Logo
4:40 pm - 8:10 amPTY-GSP
15h 30m2 stops
$404American Airlines
Find Deal
Wed, Jan 21 - Wed, Feb 4
American Airlines Logo
7:24 pm - 2:30 pmGSP-PTY
20h 06m2 stops
American Airlines Logo
3:30 pm - 10:52 amPTY-GSP
18h 22m2 stops
$408American Airlines
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Wed, Aug 13 - Tue, Aug 19
United Airlines Logo
5:34 pm - 6:37 pmGSP-PTY
26h 03m1 stop
United Airlines Logo
3:30 pm - 3:46 pmPTY-GSP
23h 16m1 stop
$420United Airlines
Find Deal
Wed, Aug 13 - Tue, Aug 19

Delta flights from Greenville to Panama City

Our best Delta deals on Greenville to Panama City flight tickets
Delta
Oct 7
GSP5:30 amGreenville
8h 26m
1 stop
PTY12:56 pmPanama City Tocumen Intl
Oct 14
PTY2:21 pmPanama City Tocumen Intl
8h 33m
1 stop
GSP11:54 pmGreenville
$341
Find similar
Delta
Jan 21
GSP6:45 amGreenville
7h 17m
1 stop
PTY2:02 pmPanama City Tocumen Intl
Feb 4
PTY3:27 pmPanama City Tocumen Intl
8h 09m
1 stop
GSP11:36 pmGreenville
$391
Find similar
Delta
Nov 22
GSP6:45 amGreenville
7h 07m
1 stop
PTY1:52 pmPanama City Tocumen Intl
Nov 29
PTY3:17 pmPanama City Tocumen Intl
8h 20m
1 stop
GSP11:37 pmGreenville
$754
Find similar

American Airlines flights from Greenville to Panama City

Our best American Airlines deals on Greenville to Panama City flight tickets
American Airlines
Oct 7
GSP6:00 amGreenville
9h 00m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Oct 14
PTY3:15 pmPanama City Tocumen Intl
19h 25m
2 stops
GSP11:40 amGreenville
$346
Find similar
American Airlines
Oct 11
GSP6:24 pmGreenville
20h 36m
2 stops
PTY2:00 pmPanama City Tocumen Intl
Oct 25
PTY3:15 pmPanama City Tocumen Intl
23h 43m
1 stop
GSP3:58 pmGreenville
$354
Find similar
American Airlines
Oct 11
GSP4:46 pmGreenville
22h 14m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Oct 25
PTY3:15 pmPanama City Tocumen Intl
23h 43m
1 stop
GSP3:58 pmGreenville
$357
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 10/7

5:30 am-12:56 pm

1 stop8h 26m

Panama City Tocumen Intl

Tue 10/14

2:21 pm-11:54 pm

1 stop8h 33m

$341

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 10/7

6:00 am-2:00 pm

1 stop9h 00m

Panama City Tocumen Intl

Tue 10/14

3:15 pm-11:40 am

2 stops19h 25m

$346

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 10/11

6:24 pm-2:00 pm

2 stops20h 36m

Panama City Tocumen Intl

Sat 10/25

3:15 pm-3:58 pm

1 stop23h 43m

$354

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 10/11

4:46 pm-2:00 pm

1 stop22h 14m

Panama City Tocumen Intl

Sat 10/25

3:15 pm-3:58 pm

1 stop23h 43m

$357

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:45 am-2:02 pm

1 stop7h 17m

Panama City Tocumen Intl

Wed 2/4

3:27 pm-11:36 pm

1 stop8h 09m

$391

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 8/28

6:45 pm-2:30 pm

2 stops20h 45m

Panama City Tocumen Intl

Thu 9/4

3:31 pm-10:55 am

2 stops18h 24m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 8/28

6:05 pm-2:30 pm

1 stop21h 25m

Panama City Tocumen Intl

Thu 9/4

3:31 pm-11:56 pm

1 stop7h 25m

$400

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

4:51 pm-3:35 pm

1 stop22h 44m

Panama City Tocumen Intl

Wed 2/4

4:40 pm-8:10 am

2 stops15h 30m

$404

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 8/13

7:24 pm-2:30 pm

2 stops20h 06m

Panama City Tocumen Intl

Tue 8/19

3:30 pm-10:52 am

2 stops18h 22m

$408

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 8/13

5:34 pm-6:37 pm

1 stop26h 03m

Panama City Tocumen Intl

Tue 8/19

3:30 pm-3:46 pm

1 stop23h 16m

$420

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from Greenville to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, November is the cheapest month to fly from Greenville to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $292. If you’re not able to fly to Panama City in November, then August is your next best option. Flight prices from Greenville to Panama City during August average around $371.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $371. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $681. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from Greenville to Panama City during this time can be as low as $441. Try not to purchase tickets at noon because they tend to be around $677. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Greenville to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to Panama City (GSP to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Panama City

Best Price Found

$341

Fastest flight time

7h 07m

Direct flights

None

Airports in Panama City

1 airport
The best flight deal from Greenville to Panama City found on momondo in the last 72 hours is $341
The fastest flight from Greenville to Panama City takes 7h 07m
There are no direct flights from Greenville to Panama City. Popular non-direct route for this connection is Greenville Airport - Panama City Tocumen Intl Airport.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is Greenville to Panama City Tocumen Intl by plane?

    A flight from Greenville to Panama City Tocumen Intl will travel around 1795.3 mi. 7h 07m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Greenville Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Greenville Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Greenville Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Greenville Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Greenville Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to Panama City?

Best airlines flying from Greenville to Panama City

Compare and see reviews for airlines that fly from Greenville to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $352Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights
DeltaPriceFrom $371Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $376Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Panama City?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama City from Greenville.

Can I find flights from Greenville to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Greenville to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Greenville to Panama City?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama City from Greenville.

I’m not ready to book a flight from Greenville to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Greenville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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