Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Greenville to Panama City from $392

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Panama City departing on 12/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Greenville to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:10 am - 3:42 pmGSP-PTY
10h 32m1 stop
American Airlines Logo
4:43 pm - 11:59 pmPTY-GSP
7h 16m1 stop
$392American Airlines
Find Deal
Wed, Dec 10 - Wed, Dec 17
American Airlines Logo
6:53 pm - 1:47 pmGSP-PTY
18h 54m2 stops
American Airlines Logo
2:50 pm - 8:36 amPTY-GSP
17h 46m2 stops
$396American Airlines
Find Deal
Wed, Dec 10 - Wed, Dec 17
United Airlines Logo
6:45 am - 7:38 pmGSP-PTY
12h 53m1 stop
United Airlines Logo
4:41 pm - 9:58 pmPTY-GSP
29h 17m1 stop
$400United Airlines
Find Deal
Thu, Nov 27 - Thu, Dec 4
United Airlines Logo
4:56 pm - 7:38 pmGSP-PTY
26h 42m1 stop
United Airlines Logo
4:41 pm - 9:59 pmPTY-GSP
29h 18m1 stop
$427United Airlines
Find Deal
Fri, Nov 14 - Mon, Nov 17
American Airlines Logo
7:55 pm - 2:20 pmGSP-PTY
19h 25m2 stops
American Airlines Logo
1:50 pm - 9:56 amPTY-GSP
19h 06m2 stops
$432American Airlines
Find Deal
Sun, Mar 15 - Sat, Mar 21
United Airlines Logo
6:50 am - 5:07 pmGSP-PTY
10h 17m1 stop
United Airlines Logo
11:35 am - 9:59 pmPTY-GSP
10h 24m1 stop
$435United Airlines
Find Deal
Thu, Feb 12 - Fri, Feb 20
Delta Logo
5:35 am - 2:12 pmGSP-PTY
8h 37m1 stop
Delta Logo
3:46 pm - 11:55 pmPTY-GSP
8h 09m1 stop
$503Delta
Find Deal
Wed, Nov 26 - Wed, Dec 3
Delta Logo
8:30 am - 7:59 pmGSP-PTY
11h 29m1 stop
Delta Logo
8:05 am - 9:54 pmPTY-GSP
13h 49m1 stop
$961Delta
Find Deal
Sat, Nov 22 - Sat, Nov 29
Multiple Airlines Logo
3:00 pm - 10:30 amGSP-PTY
19h 30m2 stops
Multiple Airlines Logo
2:55 am - 8:08 pmPTY-GSP
17h 13m3 stops
$1,071Multiple Airlines
Find Deal
Mon, Dec 15 - Sun, Jan 4
Multiple Airlines Logo
9:34 pm - 2:00 pmGSP-PTY
40h 26m3 stops
Multiple Airlines Logo
2:55 am - 4:48 pmPTY-GSP
37h 53m3 stops
$1,082Multiple Airlines
Find Deal
Sat, Nov 22 - Fri, Nov 28

American Airlines flights from Greenville to Panama City

Our best American Airlines deals on Greenville to Panama City flight tickets
American Airlines
Dec 10
GSP5:10 amGreenville
10h 32m
1 stop
PTY3:42 pmPanama City Tocumen Intl
Dec 17
PTY4:43 pmPanama City Tocumen Intl
7h 16m
1 stop
GSP11:59 pmGreenville
$392
Find similar
American Airlines
Dec 10
GSP6:53 pmGreenville
18h 54m
2 stops
PTY1:47 pmPanama City Tocumen Intl
Dec 17
PTY2:50 pmPanama City Tocumen Intl
17h 46m
2 stops
GSP8:36 amGreenville
$396
Find similar
American Airlines
Mar 15
GSP7:55 pmGreenville
19h 25m
2 stops
PTY2:20 pmPanama City Tocumen Intl
Mar 21
PTY1:50 pmPanama City Tocumen Intl
19h 06m
2 stops
GSP9:56 amGreenville
$432
Find similar

United Airlines flights from Greenville to Panama City

Our best United Airlines deals on Greenville to Panama City flight tickets
United Airlines
Nov 27
GSP6:45 amGreenville
12h 53m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Dec 4
PTY4:41 pmPanama City Tocumen Intl
29h 17m
1 stop
GSP9:58 pmGreenville
$400
Find similar
United Airlines
Nov 14
GSP4:56 pmGreenville
26h 42m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Nov 17
PTY4:41 pmPanama City Tocumen Intl
29h 18m
1 stop
GSP9:59 pmGreenville
$427
Find similar
United Airlines
Feb 12
GSP6:50 amGreenville
10h 17m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Feb 20
PTY11:35 amPanama City Tocumen Intl
10h 24m
1 stop
GSP9:59 pmGreenville
$435
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 12/10

5:10 am-3:42 pm

1 stop10h 32m

Panama City Tocumen Intl

Wed 12/17

4:43 pm-11:59 pm

1 stop7h 16m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 12/10

6:53 pm-1:47 pm

2 stops18h 54m

Panama City Tocumen Intl

Wed 12/17

2:50 pm-8:36 am

2 stops17h 46m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 11/27

6:45 am-7:38 pm

1 stop12h 53m

Panama City Tocumen Intl

Thu 12/4

4:41 pm-9:58 pm

1 stop29h 17m

$400

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Fri 11/14

4:56 pm-7:38 pm

1 stop26h 42m

Panama City Tocumen Intl

Mon 11/17

4:41 pm-9:59 pm

1 stop29h 18m

$427

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 3/15

7:55 pm-2:20 pm

2 stops19h 25m

Panama City Tocumen Intl

Sat 3/21

1:50 pm-9:56 am

2 stops19h 06m

$432

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 2/12

6:50 am-5:07 pm

1 stop10h 17m

Panama City Tocumen Intl

Fri 2/20

11:35 am-9:59 pm

1 stop10h 24m

$435

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 11/26

5:35 am-2:12 pm

1 stop8h 37m

Panama City Tocumen Intl

Wed 12/3

3:46 pm-11:55 pm

1 stop8h 09m

$503

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 11/22

8:30 am-7:59 pm

1 stop11h 29m

Panama City Tocumen Intl

Sat 11/29

8:05 am-9:54 pm

1 stop13h 49m

$961

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 12/15

3:00 pm-10:30 am

2 stops19h 30m

Panama City Tocumen Intl

Sun 1/4

2:55 am-8:08 pm

3 stops17h 13m

$1,071

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 11/22

9:34 pm-2:00 pm

3 stops40h 26m

Panama City Tocumen Intl

Fri 11/28

2:55 am-4:48 pm

3 stops37h 53m

$1,082

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from Greenville to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, August is the cheapest month to fly from Greenville to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $371. If you’re not able to fly to Panama City in August, then October is your next best option. Flight prices from Greenville to Panama City during October average around $391.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $371. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $681. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from Greenville to Panama City during this time can be as low as $441. Try not to purchase tickets at noon because they tend to be around $677. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Greenville to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to Panama City (GSP to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Panama City

Direct flights

None
There are no direct flights from Greenville to Panama City. There are no popular flight routes from Greenville to Panama City.
Search flight deals

  • How far is Greenville to Panama City Tocumen Intl by plane?

    A flight from Greenville to Panama City Tocumen Intl will travel around 1795.3 mi. 8h 28m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Greenville Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Greenville Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Greenville Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Greenville Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Greenville Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to Panama City?

Best airlines flying from Greenville to Panama City

Compare and see reviews for airlines that fly from Greenville to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $352Free CancellationRating
7.4
8,976 reviews
Search United Airlines flights
DeltaPriceFrom $371Free CancellationRating
7.9
7,975 reviews
Search Delta flights
American AirlinesPriceFrom $383Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Panama City?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama City from Greenville.

Can I find flights from Greenville to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Greenville to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Greenville to Panama City?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama City from Greenville.

I’m not ready to book a flight from Greenville to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Greenville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Panama City trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 11/13
Thu 11/20
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Panama