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Cheap flights from Greenville to Panama City from $189

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Panama City departing on 12/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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United Airlines Logo
6:49 am - 2:45 pmGSP-PTY
7h 56m1 stop
United Airlines Logo
9:55 am - 9:57 pmPTY-GSP
12h 02m1 stop
$392United Airlines
Find Deal
Wed, Jan 21 - Wed, Feb 4
American Airlines Logo
4:40 pm - 1:27 pmGSP-PTY
20h 47m2 stops
American Airlines Logo
2:27 pm - 11:24 amPTY-GSP
20h 57m2 stops
$396American Airlines
Find Deal
Wed, Jan 21 - Wed, Feb 4
United Airlines Logo
6:50 am - 2:45 pmGSP-PTY
7h 55m1 stop
United Airlines Logo
8:55 am - 5:03 pmPTY-GSP
8h 08m1 stop
$398United Airlines
Find Deal
Mon, Dec 15 - Mon, Dec 22
United Airlines Logo
6:52 am - 2:45 pmGSP-PTY
7h 53m1 stop
United Airlines Logo
3:41 pm - 9:58 pmPTY-GSP
29h 17m1 stop
$400United Airlines
Find Deal
Thu, Mar 5 - Thu, Mar 12
Delta Logo
10:06 am - 1:55 pmGSP-PTY
27h 49m1 stop
Delta Logo
3:20 pm - 6:39 pmPTY-GSP
27h 19m1 stop
$404Delta
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Sun, Jan 18 - Thu, Jan 22
American Airlines Logo
7:12 pm - 2:22 pmGSP-PTY
20h 10m1 stop
American Airlines Logo
1:44 pm - 8:38 amPTY-GSP
17h 54m2 stops
$405American Airlines
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Tue, Mar 10 - Thu, Mar 19
United Airlines Logo
5:00 pm - 2:45 pmGSP-PTY
21h 45m1 stop
United Airlines Logo
11:35 am - 9:57 pmPTY-GSP
10h 22m1 stop
$406United Airlines
Find Deal
Sun, Dec 14 - Mon, Dec 22
United Airlines Logo
5:00 pm - 5:07 pmGSP-PTY
24h 07m1 stop
United Airlines Logo
8:55 am - 9:58 pmPTY-GSP
13h 03m1 stop
$412United Airlines
Find Deal
Sun, Dec 14 - Wed, Dec 17
American Airlines Logo
7:01 pm - 3:15 pmGSP-PTY
20h 14m2 stops
American Airlines Logo
1:44 pm - 10:58 amPTY-GSP
20h 14m2 stops
$414American Airlines
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Fri, Mar 6 - Thu, Mar 12
United Airlines Logo
6:50 am - 2:45 pmGSP-PTY
7h 55m1 stop
United Airlines Logo
11:35 am - 9:57 pmPTY-GSP
10h 22m1 stop
$418United Airlines
Find Deal
Fri, Dec 12 - Mon, Dec 22

American Airlines flights from Greenville to Panama City

Our best American Airlines deals on Greenville to Panama City flight tickets
American Airlines
Jan 21
GSP4:40 pmGreenville
20h 47m
2 stops
PTY1:27 pmPanama City Tocumen Intl
Feb 4
PTY2:27 pmPanama City Tocumen Intl
20h 57m
2 stops
GSP11:24 amGreenville
$396
Find similar
American Airlines
Mar 10
GSP7:12 pmGreenville
20h 10m
1 stop
PTY2:22 pmPanama City Tocumen Intl
Mar 19
PTY1:44 pmPanama City Tocumen Intl
17h 54m
2 stops
GSP8:38 amGreenville
$405
Find similar
American Airlines
Mar 6
GSP7:01 pmGreenville
20h 14m
2 stops
PTY3:15 pmPanama City Tocumen Intl
Mar 12
PTY1:44 pmPanama City Tocumen Intl
20h 14m
2 stops
GSP10:58 amGreenville
$414
Find similar

United Airlines flights from Greenville to Panama City

Our best United Airlines deals on Greenville to Panama City flight tickets
United Airlines
Jan 21
GSP6:49 amGreenville
7h 56m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Feb 4
PTY9:55 amPanama City Tocumen Intl
12h 02m
1 stop
GSP9:57 pmGreenville
$392
Find similar
United Airlines
Dec 15
GSP6:50 amGreenville
7h 55m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Dec 22
PTY8:55 amPanama City Tocumen Intl
8h 08m
1 stop
GSP5:03 pmGreenville
$398
Find similar
United Airlines
Mar 5
GSP6:52 amGreenville
7h 53m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Mar 12
PTY3:41 pmPanama City Tocumen Intl
29h 17m
1 stop
GSP9:58 pmGreenville
$400
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:49 am-2:45 pm

1 stop7h 56m

Panama City Tocumen Intl

Wed 2/4

9:55 am-9:57 pm

1 stop12h 02m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

4:40 pm-1:27 pm

2 stops20h 47m

Panama City Tocumen Intl

Wed 2/4

2:27 pm-11:24 am

2 stops20h 57m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 12/15

6:50 am-2:45 pm

1 stop7h 55m

Panama City Tocumen Intl

Mon 12/22

8:55 am-5:03 pm

1 stop8h 08m

$398

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 3/5

6:52 am-2:45 pm

1 stop7h 53m

Panama City Tocumen Intl

Thu 3/12

3:41 pm-9:58 pm

1 stop29h 17m

$400

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 1/18

10:06 am-1:55 pm

1 stop27h 49m

Panama City Tocumen Intl

Thu 1/22

3:20 pm-6:39 pm

1 stop27h 19m

$404

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 3/10

7:12 pm-2:22 pm

1 stop20h 10m

Panama City Tocumen Intl

Thu 3/19

1:44 pm-8:38 am

2 stops17h 54m

$405

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 12/14

5:00 pm-2:45 pm

1 stop21h 45m

Panama City Tocumen Intl

Mon 12/22

11:35 am-9:57 pm

1 stop10h 22m

$406

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 12/14

5:00 pm-5:07 pm

1 stop24h 07m

Panama City Tocumen Intl

Wed 12/17

8:55 am-9:58 pm

1 stop13h 03m

$412

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Fri 3/6

7:01 pm-3:15 pm

2 stops20h 14m

Panama City Tocumen Intl

Thu 3/12

1:44 pm-10:58 am

2 stops20h 14m

$414

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Fri 12/12

6:50 am-2:45 pm

1 stop7h 55m

Panama City Tocumen Intl

Mon 12/22

11:35 am-9:57 pm

1 stop10h 22m

$418

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Greenville to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Greenville and Panama City?

What is the cheapest month to fly to Panama City?

In general, August is the cheapest month to fly from Greenville to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $371. If you’re not able to fly to Panama City in August, then October is your next best option. Flight prices from Greenville to Panama City during October average around $391.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $371. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $681. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from Greenville to Panama City during this time can be as low as $441. Try not to purchase tickets at noon because they tend to be around $677. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Greenville to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to Panama City (GSP to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Panama City

Fastest flight time

7h 53m

Direct flights

None
The fastest flight from Greenville to Panama City takes 7h 53m
There are no direct flights from Greenville to Panama City. There are no popular flight routes from Greenville to Panama City.
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  • How far is Greenville to Panama City Tocumen Intl by plane?

    A flight from Greenville to Panama City Tocumen Intl will travel around 1795.3 mi. 7h 18m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Greenville Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Greenville Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Greenville Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Greenville Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Greenville Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Greenville to Panama City?

Best airlines flying from Greenville to Panama City

Compare and see reviews for airlines that fly from Greenville to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $371Free CancellationRating
7.9
7,998 reviews
Search Delta flights
United AirlinesPriceFrom $383Free CancellationRating
7.4
9,046 reviews
Search United Airlines flights
American AirlinesPriceFrom $383Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Panama City?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama City from Greenville.

Can I find flights from Greenville to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Greenville to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Greenville to Panama City?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama City from Greenville.

I’m not ready to book a flight from Greenville to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Greenville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Fri 12/26
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