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Cheap flights from Detroit Metropolitan Wayne County Airport to Santiago from $491

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Santiago departing on 12/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Air Canada Logo
6:20 pm - 6:50 amDTW  Detroit Metropolitan Wayne County-SCL Santiago Arturo Merino Benitez
34h 30m2 stops Toronto Pearson Intl Montreal Pierre Elliott Trudeau Intl
Air Canada Logo
8:25 am - 5:40 pmSCL  Santiago Arturo Merino Benitez-DTW Detroit Metropolitan Wayne County
35h 15m2 stops Montreal Pierre Elliott Trudeau Intl Toronto Pearson Intl
$898Air Canada
Mon, Jan 11 - Tue, Feb 9
Multiple Airlines Logo
5:21 pm - 12:45 pmDTW  Detroit Metropolitan Wayne County-SCL Santiago Arturo Merino Benitez
19h 24m2 stops Orlando Sao Paulo Guarulhos Intl
Multiple Airlines Logo
3:20 pm - 5:22 pmSCL  Santiago Arturo Merino Benitez-DTW Detroit Metropolitan Wayne County
50h 02m2 stops Bogotá El Dorado Fort Lauderdale
$938Multiple Airlines
Wed, Aug 19 - Sun, Aug 23
Air Canada Logo
6:20 pm - 6:50 amDTW  Detroit Metropolitan Wayne County-SCL Santiago Arturo Merino Benitez
34h 30m2 stops Toronto Pearson Intl Montreal Pierre Elliott Trudeau Intl
Air Canada Logo
9:55 pm - 5:40 pmSCL  Santiago Arturo Merino Benitez-DTW Detroit Metropolitan Wayne County
21h 45m1 stop Toronto Pearson Intl
$985Air Canada
Sun, Jan 10 - Sat, Jan 30
Air Canada Logo
6:20 pm - 12:15 pmDTW  Detroit Metropolitan Wayne County-SCL Santiago Arturo Merino Benitez
15h 55m1 stop Toronto Pearson Intl
Air Canada Logo
8:25 am - 5:40 pmSCL  Santiago Arturo Merino Benitez-DTW Detroit Metropolitan Wayne County
35h 15m2 stops Montreal Pierre Elliott Trudeau Intl Toronto Pearson Intl
$985Air Canada
Mon, Jan 11 - Tue, Feb 9
Delta Logo
7:20 pm - 8:15 amDTW  Detroit Metropolitan Wayne County-SCL Santiago Arturo Merino Benitez
11h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:55 pm - 4:25 pmSCL  Santiago Arturo Merino Benitez-DTW Detroit Metropolitan Wayne County
17h 30m1 stop Miami
$1,490Delta
Sat, Oct 3 - Sat, Oct 24
Delta Logo
3:55 pm - 6:40 amDTW  Detroit Metropolitan Wayne County-SCL Santiago Arturo Merino Benitez
12h 45m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:00 pm - 8:13 pmSCL  Santiago Arturo Merino Benitez-DTW Detroit Metropolitan Wayne County
23h 13m1 stop Atlanta Hartsfield-Jackson
$1,600Delta
Sun, Dec 20 - Sun, Dec 27
Delta Logo
7:30 am - 6:40 amDTW  Detroit Metropolitan Wayne County-SCL Santiago Arturo Merino Benitez
21h 10m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:00 pm - 11:21 amSCL  Santiago Arturo Merino Benitez-DTW Detroit Metropolitan Wayne County
14h 21m1 stop Atlanta Hartsfield-Jackson
$1,610Delta
Sun, Dec 20 - Wed, Dec 30
Delta Logo
7:45 pm - 6:40 amDTW  Detroit Metropolitan Wayne County-SCL Santiago Arturo Merino Benitez
32h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:00 pm - 5:09 pmSCL  Santiago Arturo Merino Benitez-DTW Detroit Metropolitan Wayne County
20h 09m1 stop Atlanta Hartsfield-Jackson
$1,613Delta
Sat, Dec 19 - Sun, Dec 27
Delta Logo
7:45 pm - 6:40 amDTW  Detroit Metropolitan Wayne County-SCL Santiago Arturo Merino Benitez
32h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:50 pm - 3:11 pmSCL  Santiago Arturo Merino Benitez-DTW Detroit Metropolitan Wayne County
19h 21m1 stop Atlanta Hartsfield-Jackson
$1,613Delta
Sat, Dec 19 - Sat, Dec 26
Delta Logo
7:45 pm - 6:40 amDTW  Detroit Metropolitan Wayne County-SCL Santiago Arturo Merino Benitez
32h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:00 pm - 5:09 pmSCL  Santiago Arturo Merino Benitez-DTW Detroit Metropolitan Wayne County
20h 09m1 stop Atlanta Hartsfield-Jackson
$1,623Delta
Sat, Dec 19 - Mon, Dec 28

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Air Canada flights from Detroit Metropolitan Wayne County Airport to Santiago

Our best Air Canada deals on Detroit Metropolitan Wayne County Airport to Santiago flight tickets
Air Canada
Jan 11
DTW6:20 pmDetroit Metropolitan Wayne County
34h 30m
2 stops
SCL6:50 amSantiago Arturo Merino Benitez
Feb 9
SCL8:25 amSantiago Arturo Merino Benitez
35h 15m
2 stops
DTW5:40 pmDetroit Metropolitan Wayne County
$898
Air Canada
Jan 11
DTW6:20 pmDetroit Metropolitan Wayne County
15h 55m
1 stop
SCL12:15 pmSantiago Arturo Merino Benitez
Feb 9
SCL8:25 amSantiago Arturo Merino Benitez
35h 15m
2 stops
DTW5:40 pmDetroit Metropolitan Wayne County
$985
Air Canada
Nov 25
DTW6:20 pmDetroit Metropolitan Wayne County
34h 30m
2 stops
SCL6:50 amSantiago Arturo Merino Benitez
Nov 29
SCL8:25 amSantiago Arturo Merino Benitez
35h 15m
2 stops
DTW5:40 pmDetroit Metropolitan Wayne County
$1,018

LATAM Airlines flights from Detroit Metropolitan Wayne County Airport to Santiago

Our best LATAM Airlines deals on Detroit Metropolitan Wayne County Airport to Santiago flight tickets
LATAM Airlines
Nov 18
DTW2:40 pmDetroit Metropolitan Wayne County
14h 15m
1 stop
SCL6:55 amSantiago Arturo Merino Benitez
Nov 25
SCL11:10 pmSantiago Arturo Merino Benitez
13h 56m
1 stop
DTW11:06 amDetroit Metropolitan Wayne County
$1,164
LATAM Airlines
Nov 19
DTW10:10 amDetroit Metropolitan Wayne County
18h 40m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
Dec 11
SCL11:10 pmSantiago Arturo Merino Benitez
19h 10m
1 stop
DTW4:20 pmDetroit Metropolitan Wayne County
$1,245
LATAM Airlines
Jan 9
DTW10:15 amDetroit Metropolitan Wayne County
18h 35m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
Jan 17
SCL1:40 pmSantiago Arturo Merino Benitez
23h 24m
2 stops
DTW11:04 amDetroit Metropolitan Wayne County
$1,304

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 6, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitSantiago

DTW Detroit Metropolitan Wayne County - SCL Santiago Arturo Merino Benitez

DTWSCL

Detroit Metropolitan Wayne County

Mon 1/11

6:20 pm-6:50 am

2 stops34h 30m

Santiago Arturo Merino Benitez

Tue 2/9

8:25 am-5:40 pm

2 stops35h 15m

$898

DetroitSantiago

DTW Detroit Metropolitan Wayne County - SCL Santiago Arturo Merino Benitez

DTWSCL

Detroit Metropolitan Wayne County

Wed 8/19

5:21 pm-12:45 pm

2 stops19h 24m

Santiago Arturo Merino Benitez

Sun 8/23

3:20 pm-5:22 pm

2 stops50h 02m

$938

DetroitSantiago

DTW Detroit Metropolitan Wayne County - SCL Santiago Arturo Merino Benitez

DTWSCL

Detroit Metropolitan Wayne County

Sun 1/10

6:20 pm-6:50 am

2 stops34h 30m

Santiago Arturo Merino Benitez

Sat 1/30

9:55 pm-5:40 pm

1 stop21h 45m

$985

DetroitSantiago

DTW Detroit Metropolitan Wayne County - SCL Santiago Arturo Merino Benitez

DTWSCL

Detroit Metropolitan Wayne County

Mon 1/11

6:20 pm-12:15 pm

1 stop15h 55m

Santiago Arturo Merino Benitez

Tue 2/9

8:25 am-5:40 pm

2 stops35h 15m

$985
Quickest round-trip

DetroitSantiago

DTW Detroit Metropolitan Wayne County - SCL Santiago Arturo Merino Benitez

DTWSCL

Detroit Metropolitan Wayne County

Sat 10/3

7:20 pm-8:15 am

1 stop11h 55m

Santiago Arturo Merino Benitez

Sat 10/24

11:55 pm-4:25 pm

1 stop17h 30m

$1,490

DetroitSantiago

DTW Detroit Metropolitan Wayne County - SCL Santiago Arturo Merino Benitez

DTWSCL

Detroit Metropolitan Wayne County

Sun 12/20

3:55 pm-6:40 am

1 stop12h 45m

Santiago Arturo Merino Benitez

Sun 12/27

11:00 pm-8:13 pm

1 stop23h 13m

$1,600

DetroitSantiago

DTW Detroit Metropolitan Wayne County - SCL Santiago Arturo Merino Benitez

DTWSCL

Detroit Metropolitan Wayne County

Sun 12/20

7:30 am-6:40 am

1 stop21h 10m

Santiago Arturo Merino Benitez

Wed 12/30

11:00 pm-11:21 am

1 stop14h 21m

$1,610

DetroitSantiago

DTW Detroit Metropolitan Wayne County - SCL Santiago Arturo Merino Benitez

DTWSCL

Detroit Metropolitan Wayne County

Sat 12/19

7:45 pm-6:40 am

1 stop32h 55m

Santiago Arturo Merino Benitez

Sun 12/27

11:00 pm-5:09 pm

1 stop20h 09m

$1,613

DetroitSantiago

DTW Detroit Metropolitan Wayne County - SCL Santiago Arturo Merino Benitez

DTWSCL

Detroit Metropolitan Wayne County

Sat 12/19

7:45 pm-6:40 am

1 stop32h 55m

Santiago Arturo Merino Benitez

Sat 12/26

9:50 pm-3:11 pm

1 stop19h 21m

$1,613

DetroitSantiago

DTW Detroit Metropolitan Wayne County - SCL Santiago Arturo Merino Benitez

DTWSCL

Detroit Metropolitan Wayne County

Sat 12/19

7:45 pm-6:40 am

1 stop32h 55m

Santiago Arturo Merino Benitez

Mon 12/28

11:00 pm-5:09 pm

1 stop20h 09m

$1,623

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How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Santiago

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Can stopping save me money on Detroit Metropolitan Wayne County Airport to Santiago flights?

You could potentially save up to 32% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to Santiago flight.

When to book flights from Detroit Metropolitan Wayne County Airport to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Santiago (DTW to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Santiago

Fastest flight time

11h 55m

Direct flights

None
The fastest flight from Detroit Metropolitan Wayne County Airport to Santiago takes 11h 55m
There are no direct flights from Detroit Metropolitan Wayne County Airport to Santiago. There are no popular flight routes from Detroit Metropolitan Wayne County Airport to Santiago.
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Frequently asked questions about flying from Detroit Metropolitan Wayne County Airport to Santiago

  • How far is Detroit Metropolitan Wayne County to Santiago Arturo Merino Benitez by plane?

    Santiago Arturo Merino Benitez is 5286.2 mi away from Detroit Metropolitan Wayne County. By plane, this route typically takes 11h 55m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Santiago Arturo Merino Benitez Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to Santiago?

Best airlines flying from Detroit Metropolitan Wayne County Airport to Santiago

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Santiago with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $563Free CancellationRating
7.8
8,491 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
San Fernando
Valle Nevado
Pichilemu
Zapallar

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momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Detroit to Santiago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

Once you have performed a search for Detroit to Santiago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Detroit to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from Detroit. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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