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Cheap flights from Detroit Metropolitan Wayne County Airport to Panama from $174

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Panama departing on 2/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:15 am - 1:00 am
DTW
-
PTY
19h 45m2 stops
Multiple Airlines Logo
9:45 am - 10:12 pm
PTY
-
DTW
12h 27m2 stops
$494Multiple Airlines
Tue, Feb 3 - Tue, Feb 10
Multiple Airlines Logo
5:15 am - 1:00 am
DTW
-
PTY
19h 45m2 stops
Multiple Airlines Logo
2:55 am - 9:39 pm
PTY
-
DTW
18h 44m2 stops
$504Multiple Airlines
Sun, Jan 25 - Thu, Feb 26
Multiple Airlines Logo
2:47 pm - 8:50 am
DTW
-
PTY
18h 03m2 stops
Multiple Airlines Logo
10:25 am - 10:12 pm
PTY
-
DTW
11h 47m1 stop
$518Multiple Airlines
Tue, Feb 3 - Tue, Feb 10
Multiple Airlines Logo
7:14 pm - 8:06 am
DTW
-
PTY
12h 52m2 stops
Multiple Airlines Logo
9:33 pm - 9:11 am
PTY
-
DTW
11h 38m1 stop
$524Multiple Airlines
Sun, Feb 8 - Tue, Feb 17
Multiple Airlines Logo
7:14 pm - 8:34 pm
DTW
-
PTY
25h 20m1 stop
Multiple Airlines Logo
5:50 pm - 9:39 pm
PTY
-
DTW
27h 49m2 stops
$535Multiple Airlines
Sun, Jan 25 - Fri, Feb 27
Multiple Airlines Logo
12:56 pm - 8:50 am
DTW
-
PTY
19h 54m2 stops
Multiple Airlines Logo
9:33 pm - 10:08 am
PTY
-
DTW
12h 35m1 stop
$554Multiple Airlines
Fri, Jan 23 - Fri, Feb 13
Multiple Airlines Logo
12:30 pm - 8:37 pm
DTW
-
PTY
8h 07m1 stop
Multiple Airlines Logo
7:50 pm - 11:16 am
PTY
-
DTW
39h 26m2 stops
$559Multiple Airlines
Sat, Jan 17 - Sat, Jan 24
Multiple Airlines Logo
6:09 am - 8:37 pm
DTW
-
PTY
14h 28m2 stops
Multiple Airlines Logo
12:33 pm - 10:43 pm
PTY
-
DTW
10h 10m1 stop
$562Multiple Airlines
Wed, Jan 28 - Thu, Feb 12
Multiple Airlines Logo
2:36 pm - 8:34 pm
DTW
-
PTY
29h 58m1 stop
Multiple Airlines Logo
5:50 pm - 11:16 am
PTY
-
DTW
17h 26m2 stops
$565Multiple Airlines
Wed, Jan 21 - Sun, Jan 25
Multiple Airlines Logo
7:14 pm - 8:34 pm
DTW
-
PTY
25h 20m1 stop
Multiple Airlines Logo
5:50 pm - 9:15 am
PTY
-
DTW
39h 25m2 stops
$566Multiple Airlines
Sun, Jan 25 - Sun, Mar 1

American Airlines flights from Detroit Metropolitan Wayne County Airport to Panama

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Panama flight tickets
American Airlines
Mar 11
DTW6:00 amDetroit Metropolitan Wayne County
9h 22m
1 stop
PTY2:22 pmPanama City Tocumen Intl
Mar 21
PTY1:44 pmPanama City Tocumen Intl
22h 57m
2 stops
DTW1:41 pmDetroit Metropolitan Wayne County
$661
Find similar
American Airlines
Mar 14
DTW7:39 pmDetroit Metropolitan Wayne County
19h 43m
2 stops
PTY2:22 pmPanama City Tocumen Intl
Mar 22
PTY3:13 pmPanama City Tocumen Intl
21h 28m
2 stops
DTW1:41 pmDetroit Metropolitan Wayne County
$686
Find similar
American Airlines
Mar 14
DTW7:39 pmDetroit Metropolitan Wayne County
19h 43m
2 stops
PTY2:22 pmPanama City Tocumen Intl
Mar 22
PTY3:13 pmPanama City Tocumen Intl
19h 44m
1 stop
DTW11:57 amDetroit Metropolitan Wayne County
$701
Find similar

United Airlines flights from Detroit Metropolitan Wayne County Airport to Panama

Our best United Airlines deals on Detroit Metropolitan Wayne County Airport to Panama flight tickets
United Airlines
Mar 7
DTW11:46 amDetroit Metropolitan Wayne County
8h 16m
1 stop
PTY8:02 pmPanama City Tocumen Intl
Mar 17
PTY7:55 amPanama City Tocumen Intl
11h 15m
2 stops
DTW8:10 pmDetroit Metropolitan Wayne County
$700
Find similar
United Airlines
Mar 11
DTW6:15 amDetroit Metropolitan Wayne County
13h 23m
1 stop
PTY6:38 pmPanama City Tocumen Intl
Mar 21
PTY3:41 pmPanama City Tocumen Intl
31h 17m
1 stop
DTW11:58 pmDetroit Metropolitan Wayne County
$702
Find similar
United Airlines
Jan 12
DTW11:31 amDetroit Metropolitan Wayne County
8h 31m
1 stop
PTY8:02 pmPanama City Tocumen Intl
Mar 11
PTY9:30 amPanama City Tocumen Intl
9h 03m
1 stop
DTW7:33 pmDetroit Metropolitan Wayne County
$709
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 21, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 2/3

5:15 am-1:00 am

2 stops19h 45m

Panama City Tocumen Intl

Tue 2/10

9:45 am-10:12 pm

2 stops12h 27m

$494

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 1/25

5:15 am-1:00 am

2 stops19h 45m

Panama City Tocumen Intl

Thu 2/26

2:55 am-9:39 pm

2 stops18h 44m

$504

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 2/3

2:47 pm-8:50 am

2 stops18h 03m

Panama City Tocumen Intl

Tue 2/10

10:25 am-10:12 pm

1 stop11h 47m

$518

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 2/8

7:14 pm-8:06 am

2 stops12h 52m

Panama City Tocumen Intl

Tue 2/17

9:33 pm-9:11 am

1 stop11h 38m

$524

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 1/25

7:14 pm-8:34 pm

1 stop25h 20m

Panama City Tocumen Intl

Fri 2/27

5:50 pm-9:39 pm

2 stops27h 49m

$535

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Fri 1/23

12:56 pm-8:50 am

2 stops19h 54m

Panama City Tocumen Intl

Fri 2/13

9:33 pm-10:08 am

1 stop12h 35m

$554

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 1/17

12:30 pm-8:37 pm

1 stop8h 07m

Panama City Tocumen Intl

Sat 1/24

7:50 pm-11:16 am

2 stops39h 26m

$559

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 1/28

6:09 am-8:37 pm

2 stops14h 28m

Panama City Tocumen Intl

Thu 2/12

12:33 pm-10:43 pm

1 stop10h 10m

$562

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 1/21

2:36 pm-8:34 pm

1 stop29h 58m

Panama City Tocumen Intl

Sun 1/25

5:50 pm-11:16 am

2 stops17h 26m

$565

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 1/25

7:14 pm-8:34 pm

1 stop25h 20m

Panama City Tocumen Intl

Sun 3/1

5:50 pm-9:15 am

2 stops39h 25m

$566

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of June is, on average, the cheapest month to fly to Panama from Detroit Metropolitan Wayne County Airport, with most prices found around $723. If you don’t want to visit Panama in June, then you should wait until October to fly from Detroit Metropolitan Wayne County Airport, when ticket prices are also cheap, with an average price of $736.

What is the cheapest day to depart on your flight to Panama?

According to our data, Wednesday is the cheapest day to fly to Panama from Detroit Metropolitan Wayne County Airport. The lowest ticket price found for a Wednesday departure recently was $733. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Detroit Metropolitan Wayne County Airport to Panama for around $891.

What is the cheapest time of day to depart on your flight to Panama?

In the evening is the cheapest time of day to fly from Detroit Metropolitan Wayne County Airport to Panama when you can find flight prices for as low as $767. Flying to Panama in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Panama, so prices are often more expensive at around $794 per ticket.

Cheap Detroit Metropolitan Wayne County Airport to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Panama

Fastest flight time

8h 13m

Direct flights

None
The fastest flight from Detroit Metropolitan Wayne County Airport to Panama takes 8h 13m
There are no direct flights from Detroit Metropolitan Wayne County Airport to Panama. There are no popular flight routes from Detroit Metropolitan Wayne County Airport to Panama.
Search flight deals

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Panama?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Panama refresh daily.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Panama?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit Metropolitan Wayne County Airport to Panama

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Panama with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $578Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
United AirlinesPriceFrom $608Free CancellationRating
7.4
9,099 reviews
Search United Airlines flights
DeltaPriceFrom $608Free CancellationRating
7.9
8,021 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama from Detroit.

Can I find flights from Detroit to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Panama?

Once all potential Detroit to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Detroit to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Detroit to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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