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Cheap flights from Detroit Metropolitan Wayne County Airport to Panama from $290

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Panama departing on 10/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Panama

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:30 pm - 10:30 am
DTW
-
PTY
18h 00m
2 stops
Multiple Airlines Logo
3:50 pm - 4:32 pm
PTY
-
DTW
23h 42m
2 stops
$609Multiple Airlines
Wed, Sep 30 - Sun, Oct 4
Multiple Airlines Logo
4:45 pm - 6:55 pm
DTW
-
PTY
26h 10m
2 stops
Multiple Airlines Logo
7:50 pm - 10:57 pm
PTY
-
DTW
27h 07m
2 stops
$617Multiple Airlines
Mon, Nov 16 - Tue, Dec 15
Multiple Airlines Logo
6:05 am - 10:30 am
DTW
-
PTY
29h 25m
2 stops
Multiple Airlines Logo
3:50 pm - 11:59 pm
PTY
-
DTW
31h 09m
2 stops
$619Multiple Airlines
Thu, Aug 20 - Thu, Aug 27
Multiple Airlines Logo
6:05 am - 10:30 am
DTW
-
PTY
29h 25m
2 stops
Multiple Airlines Logo
3:50 pm - 11:59 pm
PTY
-
DTW
31h 09m
2 stops
$621Multiple Airlines
Thu, Aug 20 - Thu, Aug 27
Multiple Airlines Logo
6:00 am - 6:55 pm
DTW
-
PTY
36h 55m
2 stops
Multiple Airlines Logo
3:50 pm - 10:57 pm
PTY
-
DTW
31h 07m
2 stops
$625Multiple Airlines
Thu, Dec 3 - Fri, Dec 11
Multiple Airlines Logo
6:00 am - 8:34 pm
DTW
-
PTY
15h 34m
1 stop
Multiple Airlines Logo
5:55 pm - 5:22 pm
PTY
-
DTW
46h 27m
2 stops
$628Multiple Airlines
Thu, Aug 20 - Thu, Aug 27
Multiple Airlines Logo
11:00 am - 8:19 pm
DTW
-
PTY
10h 19m
1 stop
Multiple Airlines Logo
10:10 am - 1:07 pm
PTY
-
DTW
25h 57m
2 stops
$630Multiple Airlines
Tue, Sep 15 - Tue, Sep 22
Multiple Airlines Logo
6:00 am - 10:30 am
DTW
-
PTY
28h 30m
2 stops
Multiple Airlines Logo
3:50 pm - 10:57 pm
PTY
-
DTW
31h 07m
2 stops
$634Multiple Airlines
Wed, Dec 9 - Mon, Dec 14
Multiple Airlines Logo
5:30 pm - 10:30 am
DTW
-
PTY
18h 00m
2 stops
Multiple Airlines Logo
11:25 am - 4:32 pm
PTY
-
DTW
28h 07m
3 stops
$642Multiple Airlines
Mon, Oct 12 - Fri, Oct 16
Multiple Airlines Logo
6:05 am - 10:30 am
DTW
-
PTY
29h 25m
2 stops
Multiple Airlines Logo
3:50 pm - 11:59 pm
PTY
-
DTW
31h 09m
2 stops
$644Multiple Airlines
Thu, Aug 20 - Thu, Aug 27

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Copa Airlines flights from Detroit Metropolitan Wayne County Airport to Panama

Our best Copa Airlines deals on Detroit Metropolitan Wayne County Airport to Panama flight tickets
Copa Airlines
Nov 5
DTW5:50 amDetroit Metropolitan Wayne County
7h 41m
1 stop
PTY1:31 pmPanama City Tocumen Intl
Nov 13
PTY8:05 amPanama City Tocumen Intl
12h 18m
1 stop
DTW8:23 pmDetroit Metropolitan Wayne County
$727
Copa Airlines
Oct 9
DTW5:30 amDetroit Metropolitan Wayne County
16h 11m
1 stop
PTY8:41 pmPanama City Tocumen Intl
Oct 18
PTY8:10 amPanama City Tocumen Intl
13h 05m
1 stop
DTW10:15 pmDetroit Metropolitan Wayne County
$733

United Airlines flights from Detroit Metropolitan Wayne County Airport to Panama

Our best United Airlines deals on Detroit Metropolitan Wayne County Airport to Panama flight tickets
United Airlines
Nov 17
DTW7:25 amDetroit Metropolitan Wayne County
12h 13m
2 stops
PTY7:38 pmPanama City Tocumen Intl
Dec 15
PTY11:35 amPanama City Tocumen Intl
12h 17m
2 stops
DTW11:52 pmDetroit Metropolitan Wayne County
$737
United Airlines
Nov 16
DTW8:50 amDetroit Metropolitan Wayne County
10h 48m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Dec 17
PTY11:55 pmPanama City Tocumen Intl
23h 09m
1 stop
DTW11:04 pmDetroit Metropolitan Wayne County
$742
United Airlines
Nov 18
DTW7:25 amDetroit Metropolitan Wayne County
12h 13m
2 stops
PTY7:38 pmPanama City Tocumen Intl
Dec 17
PTY11:55 pmPanama City Tocumen Intl
21h 13m
1 stop
DTW9:08 pmDetroit Metropolitan Wayne County
$746

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 2, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 9/30

5:30 pm-10:30 am

2 stops18h 00m

Panama City Tocumen Intl

Sun 10/4

3:50 pm-4:32 pm

2 stops23h 42m

$609

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 11/16

4:45 pm-6:55 pm

2 stops26h 10m

Panama City Tocumen Intl

Tue 12/15

7:50 pm-10:57 pm

2 stops27h 07m

$617

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 8/20

6:05 am-10:30 am

2 stops29h 25m

Panama City Tocumen Intl

Thu 8/27

3:50 pm-11:59 pm

2 stops31h 09m

$619

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 8/20

6:05 am-10:30 am

2 stops29h 25m

Panama City Tocumen Intl

Thu 8/27

3:50 pm-11:59 pm

2 stops31h 09m

$621

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 12/3

6:00 am-6:55 pm

2 stops36h 55m

Panama City Tocumen Intl

Fri 12/11

3:50 pm-10:57 pm

2 stops31h 07m

$625

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 8/20

6:00 am-8:34 pm

1 stop15h 34m

Panama City Tocumen Intl

Thu 8/27

5:55 pm-5:22 pm

2 stops46h 27m

$628
Quickest round-trip

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 9/15

11:00 am-8:19 pm

1 stop10h 19m

Panama City Tocumen Intl

Tue 9/22

10:10 am-1:07 pm

2 stops25h 57m

$630

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 12/9

6:00 am-10:30 am

2 stops28h 30m

Panama City Tocumen Intl

Mon 12/14

3:50 pm-10:57 pm

2 stops31h 07m

$634

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 10/12

5:30 pm-10:30 am

2 stops18h 00m

Panama City Tocumen Intl

Fri 10/16

11:25 am-4:32 pm

3 stops28h 07m

$642

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 8/20

6:05 am-10:30 am

2 stops29h 25m

Panama City Tocumen Intl

Thu 8/27

3:50 pm-11:59 pm

2 stops31h 09m

$644

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Panama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama?

The month of March is, on average, the cheapest month to fly to Panama from Detroit Metropolitan Wayne County Airport, with most prices found around $514. If you don’t want to visit Panama in March, then you should wait until October to fly from Detroit Metropolitan Wayne County Airport, when ticket prices are also cheap, with an average price of $562.

Cheap Detroit Metropolitan Wayne County Airport to Panama flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Panama

Fastest flight time

7h 41m

Direct flights

None
The fastest flight from Detroit Metropolitan Wayne County Airport to Panama takes 7h 41m
There are no direct flights from Detroit Metropolitan Wayne County Airport to Panama. There are no popular flight routes from Detroit Metropolitan Wayne County Airport to Panama.
Search flight deals

Frequently asked questions about flying from Detroit Metropolitan Wayne County Airport to Panama

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Panama?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Panama refresh daily.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Panama?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Panama?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to Panama.

  • What documentation or ID do you need to fly to Panama?

    The required travel and health documents for your Panama trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit Metropolitan Wayne County Airport to Panama

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Panama with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $611Free CancellationRating
7.6
1,565 reviews
Search Copa Airlines flights
American AirlinesPriceFrom $673Free CancellationRating
7.1
11,771 reviews
Search American Airlines flights
United AirlinesPriceFrom $708Free CancellationRating
7.4
9,925 reviews
Search United Airlines flights
DeltaPriceFrom $709Free CancellationRating
7.8
8,452 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama from Detroit.

Can I find flights from Detroit to Panama with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama from Detroit which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Detroit to Panama?

Once all potential Detroit to Panama flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Detroit to Panama right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Detroit to Panama now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama and let you know when they change.

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