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Cheap flights from Des Moines to Panama City from $613

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:20 am - 6:37 pm
DSM
-
PTY
12h 17m
1 stop
United Airlines Logo
7:55 am - 10:35 pm
PTY
-
DSM
14h 40m
1 stop
$613United Airlines
Thu, May 28 - Tue, Jun 2
United Airlines Logo
6:20 am - 6:37 pm
DSM
-
PTY
12h 17m
1 stop
United Airlines Logo
3:30 pm - 10:27 am
PTY
-
DSM
18h 57m
2 stops
$617United Airlines
Thu, May 28 - Tue, Jun 2
United Airlines Logo
6:20 am - 6:37 pm
DSM
-
PTY
12h 17m
1 stop
United Airlines Logo
3:30 pm - 2:20 pm
PTY
-
DSM
22h 50m
1 stop
$624United Airlines
Tue, May 26 - Tue, Jun 9
United Airlines Logo
6:20 am - 6:37 pm
DSM
-
PTY
12h 17m
1 stop
United Airlines Logo
7:55 am - 10:35 pm
PTY
-
DSM
14h 40m
1 stop
$658United Airlines
Tue, May 26 - Mon, Jun 8
United Airlines Logo
6:20 am - 4:12 pm
DSM
-
PTY
9h 52m
1 stop
United Airlines Logo
3:30 pm - 10:27 am
PTY
-
DSM
18h 57m
2 stops
$662United Airlines
Mon, May 25 - Mon, Jun 8
Copa Airlines Logo
6:20 am - 6:37 pm
DSM
-
PTY
12h 17m
1 stop
Copa Airlines Logo
3:30 pm - 10:27 am
PTY
-
DSM
18h 57m
2 stops
$666Copa Airlines
Tue, May 26 - Tue, Jun 9
United Airlines Logo
6:20 am - 6:37 pm
DSM
-
PTY
12h 17m
1 stop
United Airlines Logo
3:30 pm - 2:20 pm
PTY
-
DSM
22h 50m
1 stop
$669United Airlines
Mon, May 25 - Tue, Jun 9
United Airlines Logo
6:50 pm - 2:14 pm
DSM
-
PTY
19h 24m
2 stops
United Airlines Logo
3:30 pm - 2:20 pm
PTY
-
DSM
22h 50m
1 stop
$673United Airlines
Mon, May 25 - Tue, Jun 9
United Airlines Logo
6:20 am - 6:37 pm
DSM
-
PTY
12h 17m
1 stop
United Airlines Logo
7:55 am - 10:35 pm
PTY
-
DSM
14h 40m
1 stop
$703United Airlines
Mon, May 25 - Mon, Jun 8
American Airlines Logo
1:37 pm - 12:14 pm
DSM
-
PTY
22h 37m
2 stops
American Airlines Logo
1:14 pm - 9:11 am
PTY
-
DSM
19h 57m
2 stops
$715American Airlines
Thu, Jun 4 - Thu, Jun 11

United Airlines flights from Des Moines to Panama City

Our best United Airlines deals on Des Moines to Panama City flight tickets
United Airlines
May 28
DSM6:20 amDes Moines
12h 17m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Jun 2
PTY7:55 amPanama City Tocumen Intl
14h 40m
1 stop
DSM10:35 pmDes Moines
$613
United Airlines
May 28
DSM6:20 amDes Moines
12h 17m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Jun 2
PTY3:30 pmPanama City Tocumen Intl
18h 57m
2 stops
DSM10:27 amDes Moines
$617
United Airlines
May 26
DSM6:20 amDes Moines
12h 17m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Jun 9
PTY3:30 pmPanama City Tocumen Intl
22h 50m
1 stop
DSM2:20 pmDes Moines
$624

American Airlines flights from Des Moines to Panama City

Our best American Airlines deals on Des Moines to Panama City flight tickets
American Airlines
Jun 4
DSM1:37 pmDes Moines
22h 37m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Jun 11
PTY1:14 pmPanama City Tocumen Intl
19h 57m
2 stops
DSM9:11 amDes Moines
$715
American Airlines
Jun 4
DSM4:48 pmDes Moines
19h 26m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Jun 11
PTY1:14 pmPanama City Tocumen Intl
23h 38m
2 stops
DSM12:52 pmDes Moines
$716
American Airlines
May 26
DSM8:02 pmDes Moines
16h 12m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Jun 9
PTY1:14 pmPanama City Tocumen Intl
10h 56m
2 stops
DSM12:10 amDes Moines
$717

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 20, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 5/28

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Tue 6/2

7:55 am-10:35 pm

1 stop14h 40m

$613

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 5/28

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Tue 6/2

3:30 pm-10:27 am

2 stops18h 57m

$617

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 5/26

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Tue 6/9

3:30 pm-2:20 pm

1 stop22h 50m

$624

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 5/26

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Mon 6/8

7:55 am-10:35 pm

1 stop14h 40m

$658

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 5/25

6:20 am-4:12 pm

1 stop9h 52m

Panama City Tocumen Intl

Mon 6/8

3:30 pm-10:27 am

2 stops18h 57m

$662

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 5/26

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Tue 6/9

3:30 pm-10:27 am

2 stops18h 57m

$666

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 5/25

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Tue 6/9

3:30 pm-2:20 pm

1 stop22h 50m

$669

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 5/25

6:50 pm-2:14 pm

2 stops19h 24m

Panama City Tocumen Intl

Tue 6/9

3:30 pm-2:20 pm

1 stop22h 50m

$673

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 5/25

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Mon 6/8

7:55 am-10:35 pm

1 stop14h 40m

$703

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 6/4

1:37 pm-12:14 pm

2 stops22h 37m

Panama City Tocumen Intl

Thu 6/11

1:14 pm-9:11 am

2 stops19h 57m

$715

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from Des Moines to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Panama City?

What is the cheapest month to fly to Panama City?

In general, February is the cheapest month to fly from Des Moines to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $461. If you’re not able to fly to Panama City in February, then September is your next best option. Flight prices from Des Moines to Panama City during September average around $488.

Can stopping save me money on Des Moines to Panama City flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Panama City flight.

When to book flights from Des Moines to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Panama City (DSM to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City

Fastest flight time

9h 52m

Direct flights

None
The fastest flight from Des Moines to Panama City takes 9h 52m
There are no direct flights from Des Moines to Panama City. There are no popular flight routes from Des Moines to Panama City.
Search flight deals

Frequently asked questions about flying from Des Moines to Panama City

  • How far is Des Moines to Panama City Tocumen Intl by plane?

    The distance between Des Moines and Panama City Tocumen Intl is about 2409.5 mi. Flights usually cover this in 9h 52m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Panama City Tocumen Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Panama City?

Best airlines flying from Des Moines to Panama City

Compare and see reviews for airlines that fly from Des Moines to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $441Free CancellationRating
7.9
8,422 reviews
Search Delta flights
United AirlinesPriceFrom $461Free CancellationRating
7.4
9,607 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Panama City for you.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Flights from Des Moines to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Panama City?

momondo helps you find the best flight between Des Moines and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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