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Cheap flights from Des Moines to Panama City from $214

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 8/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:08 pm - 12:40 pm
DSM
-
PTY
18h 32m
2 stops
American Airlines Logo
1:49 pm - 11:26 am
PTY
-
DSM
21h 37m
2 stops
$482American Airlines
Tue, Mar 31 - Tue, Apr 7
American Airlines Logo
7:00 am - 3:01 pm
DSM
-
PTY
8h 01m
1 stop
American Airlines Logo
1:49 pm - 11:26 am
PTY
-
DSM
21h 37m
2 stops
$485American Airlines
Tue, Mar 31 - Tue, Apr 7
United Airlines Logo
8:04 am - 6:37 pm
DSM
-
PTY
10h 33m
2 stops
United Airlines Logo
7:55 am - 10:43 pm
PTY
-
DSM
14h 48m
1 stop
$493United Airlines
Tue, Mar 31 - Tue, Apr 7
American Airlines Logo
2:00 pm - 12:40 pm
DSM
-
PTY
22h 40m
2 stops
American Airlines Logo
1:49 pm - 11:26 am
PTY
-
DSM
21h 37m
2 stops
$495American Airlines
Tue, Mar 31 - Tue, Apr 7
United Airlines Logo
8:20 am - 4:12 pm
DSM
-
PTY
7h 52m
1 stop
United Airlines Logo
3:30 pm - 10:37 am
PTY
-
DSM
19h 07m
2 stops
$497United Airlines
Sun, Apr 26 - Sun, May 3
American Airlines Logo
7:00 am - 12:40 pm
DSM
-
PTY
29h 40m
1 stop
American Airlines Logo
1:49 pm - 2:47 pm
PTY
-
DSM
24h 58m
2 stops
$498American Airlines
Tue, Mar 31 - Tue, Apr 7
United Airlines Logo
6:20 am - 6:37 pm
DSM
-
PTY
12h 17m
1 stop
United Airlines Logo
4:41 pm - 2:20 pm
PTY
-
DSM
22h 39m
1 stop
$502United Airlines
Sat, Aug 1 - Tue, Jan 12
United Airlines Logo
1:10 pm - 4:04 am
DSM
-
PTY
14h 54m
2 stops
United Airlines Logo
3:30 pm - 2:22 pm
PTY
-
DSM
22h 52m
1 stop
$507United Airlines
Fri, Apr 3 - Fri, Apr 10
United Airlines Logo
6:20 am - 7:31 pm
DSM
-
PTY
13h 11m
2 stops
United Airlines Logo
7:55 am - 10:43 pm
PTY
-
DSM
14h 48m
1 stop
$529United Airlines
Wed, Apr 22 - Sun, Apr 26
LATAM Airlines Logo
5:45 am - 1:07 pm
DSM
-
PTY
7h 22m
1 stop
LATAM Airlines Logo
2:28 pm - 5:42 pm
PTY
-
DSM
27h 14m
1 stop
$535LATAM Airlines
Tue, Aug 4 - Sat, Aug 22

Delta flights from Des Moines to Panama City

Our best Delta deals on Des Moines to Panama City flight tickets
Delta
Mar 31
DSM5:35 amDes Moines
7h 28m
1 stop
PTY1:03 pmPanama City Tocumen Intl
Apr 7
PTY2:28 pmPanama City Tocumen Intl
8h 10m
1 stop
DSM10:38 pmDes Moines
$703
Delta
Apr 1
DSM5:35 amDes Moines
7h 28m
1 stop
PTY1:03 pmPanama City Tocumen Intl
Apr 8
PTY2:28 pmPanama City Tocumen Intl
8h 10m
1 stop
DSM10:38 pmDes Moines
$848

American Airlines flights from Des Moines to Panama City

Our best American Airlines deals on Des Moines to Panama City flight tickets
American Airlines
Mar 31
DSM6:08 pmDes Moines
18h 32m
2 stops
PTY12:40 pmPanama City Tocumen Intl
Apr 7
PTY1:49 pmPanama City Tocumen Intl
21h 37m
2 stops
DSM11:26 amDes Moines
$482
American Airlines
Mar 31
DSM7:00 amDes Moines
8h 01m
1 stop
PTY3:01 pmPanama City Tocumen Intl
Apr 7
PTY1:49 pmPanama City Tocumen Intl
21h 37m
2 stops
DSM11:26 amDes Moines
$485
American Airlines
Mar 31
DSM2:00 pmDes Moines
22h 40m
2 stops
PTY12:40 pmPanama City Tocumen Intl
Apr 7
PTY1:49 pmPanama City Tocumen Intl
21h 37m
2 stops
DSM11:26 amDes Moines
$495

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 17, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 3/31

6:08 pm-12:40 pm

2 stops18h 32m

Panama City Tocumen Intl

Tue 4/7

1:49 pm-11:26 am

2 stops21h 37m

$482

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 3/31

7:00 am-3:01 pm

1 stop8h 01m

Panama City Tocumen Intl

Tue 4/7

1:49 pm-11:26 am

2 stops21h 37m

$485

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 3/31

8:04 am-6:37 pm

2 stops10h 33m

Panama City Tocumen Intl

Tue 4/7

7:55 am-10:43 pm

1 stop14h 48m

$493

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 3/31

2:00 pm-12:40 pm

2 stops22h 40m

Panama City Tocumen Intl

Tue 4/7

1:49 pm-11:26 am

2 stops21h 37m

$495

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 4/26

8:20 am-4:12 pm

1 stop7h 52m

Panama City Tocumen Intl

Sun 5/3

3:30 pm-10:37 am

2 stops19h 07m

$497

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 3/31

7:00 am-12:40 pm

1 stop29h 40m

Panama City Tocumen Intl

Tue 4/7

1:49 pm-2:47 pm

2 stops24h 58m

$498

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 8/1

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Tue 1/12

4:41 pm-2:20 pm

1 stop22h 39m

$502

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 4/3

1:10 pm-4:04 am

2 stops14h 54m

Panama City Tocumen Intl

Fri 4/10

3:30 pm-2:22 pm

1 stop22h 52m

$507

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 4/22

6:20 am-7:31 pm

2 stops13h 11m

Panama City Tocumen Intl

Sun 4/26

7:55 am-10:43 pm

1 stop14h 48m

$529

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 8/4

5:45 am-1:07 pm

1 stop7h 22m

Panama City Tocumen Intl

Sat 8/22

2:28 pm-5:42 pm

1 stop27h 14m

$535

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Des Moines to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, September is the cheapest month to fly from Des Moines to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $441. If you’re not able to fly to Panama City in September, then July is your next best option. Flight prices from Des Moines to Panama City during July average around $455.

Can stopping save me money on Des Moines to Panama City flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Panama City flight.

When to book flights from Des Moines to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Panama City (DSM to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City

Fastest flight time

10h 17m

Direct flights

None
The fastest flight from Des Moines to Panama City takes 10h 17m
There are no direct flights from Des Moines to Panama City. There are no popular flight routes from Des Moines to Panama City.
Search flight deals

  • How far is Des Moines to Panama City Tocumen Intl by plane?

    The distance between Des Moines and Panama City Tocumen Intl is about 2409.5 mi. Flights usually cover this in 10h 17m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Panama City Tocumen Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Panama City?

Best airlines flying from Des Moines to Panama City

Compare and see reviews for airlines that fly from Des Moines to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $441Free CancellationRating
7.4
9,312 reviews
Search United Airlines flights
DeltaPriceFrom $441Free CancellationRating
7.9
8,207 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Panama City for you.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Flights from Des Moines to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Panama City?

momondo helps you find the best flight between Des Moines and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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