Which airport is the most popular layover for flights between Des Moines and Panama City?

Houston (IAH) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from Des Moines to Panama City?

Flights via Houston (IAH) offer the lowest average round-trip price of $495.

Which layover airport has the shortest connection time from Des Moines to Panama City?

Atlanta (ATL) has the shortest average layover time for this route: 1h 14m.

What airlines fly to Panama City?

United Airlines, Delta and American Airlines are the top three most popular airlines that fly to Panama City from Des Moines according to our data. United Airlines is the first choice among our users, with 51% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 3 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to Panama City Tocumen Intl?

United Airlines is the most popular carrier operating from Des Moines to Panama City Tocumen Intl

Which layover airport has the shortest travel time from Des Moines to Panama City?

Flights connecting via Atlanta (ATL) have the shortest average one-way travel time: 7h 09m.

When did momondo last update prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

Prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

As of August 2025, there are 3 operators available to choose from for flights from Des Moines Airport to Panama City Tocumen Intl Airport.

How old do you have to be to fly from Des Moines Airport to Panama City Tocumen Intl Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama City Tocumen Intl Airport.

What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$198 Cheap Flights from Des Moines to Panama City (DSM-PTY) in 2025

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Find the cheapest flights from Des Moines to Panama City (DSM-PTY)

Round-trip

One-way

Cheap round-trip flights

6:08 am - 6:37 pmDSM-PTY

12h 29m1 stop

3:30 pm - 2:13 pmPTY-DSM

22h 43m1 stop

$449United Airlines

Find Deal

Fri, Oct 10 - Fri, Oct 17

6:08 am - 6:37 pmDSM-PTY

12h 29m1 stop

3:30 pm - 2:13 pmPTY-DSM

22h 43m1 stop

$452United Airlines

Find Deal

Fri, Oct 10 - Fri, Oct 17

6:08 am - 6:37 pmDSM-PTY

12h 29m1 stop

3:30 pm - 2:13 pmPTY-DSM

22h 43m1 stop

$456United Airlines

Find Deal

Fri, Oct 10 - Fri, Oct 17

5:42 pm - 2:03 pmDSM-PTY

20h 21m2 stops

3:15 pm - 8:22 amPTY-DSM

17h 07m2 stops

$465American Airlines

Find Deal

Wed, Oct 8 - Wed, Oct 15

6:07 pm - 2:03 pmDSM-PTY

19h 56m2 stops

3:15 pm - 5:42 pmPTY-DSM

26h 27m2 stops

$471American Airlines

Find Deal

Sun, Oct 12 - Sun, Oct 19

12:30 pm - 12:56 pmDSM-PTY

24h 26m2 stops

2:21 pm - 10:26 amPTY-DSM

20h 05m2 stops

$491Delta

Find Deal

Sat, Oct 18 - Sat, Oct 25

6:39 pm - 12:56 pmDSM-PTY

18h 17m1 stop

2:21 pm - 10:30 pmPTY-DSM

8h 09m1 stop

$513Delta

Find Deal

Thu, Oct 16 - Sat, Oct 25

6:15 am - 6:37 pmDSM-PTY

12h 22m1 stop

10:00 am - 10:22 pmPTY-DSM

12h 22m1 stop

$709Lufthansa

Find Deal

Thu, Oct 9 - Thu, Oct 16

10:51 am - 6:33 amDSM-PTY

19h 42m2 stops

3:20 am - 5:14 pmPTY-DSM

37h 54m3 stops

$766

Find Deal

Thu, Oct 9 - Wed, Oct 15

4:39 pm - 5:16 pmDSM-PTY

24h 37m3 stops

5:25 pm - 5:01 pmPTY-DSM

23h 36m3 stops

$767

Find Deal

Sun, Oct 12 - Sun, Oct 19

United Airlines flights from Des Moines to Panama City

Our best United Airlines deals on Des Moines to Panama City flight tickets

United Airlines

Oct 10

DSM6:08 amDes Moines

12h 29m

1 stop

PTY6:37 pmPanama City Tocumen Intl

Oct 17

PTY3:30 pmPanama City Tocumen Intl

22h 43m

1 stop

DSM2:13 pmDes Moines

$449

Find similar

United Airlines

Oct 10

DSM6:08 amDes Moines

12h 29m

1 stop

PTY6:37 pmPanama City Tocumen Intl

Oct 17

PTY3:30 pmPanama City Tocumen Intl

22h 43m

1 stop

DSM2:13 pmDes Moines

$452

Find similar

United Airlines

Oct 10

DSM6:08 amDes Moines

12h 29m

1 stop

PTY6:37 pmPanama City Tocumen Intl

Oct 17

PTY3:30 pmPanama City Tocumen Intl

22h 43m

1 stop

DSM2:13 pmDes Moines

$456

Find similar

American Airlines flights from Des Moines to Panama City

Our best American Airlines deals on Des Moines to Panama City flight tickets

American Airlines

Oct 8

DSM5:42 pmDes Moines

20h 21m

2 stops

PTY2:03 pmPanama City Tocumen Intl

Oct 15

PTY3:15 pmPanama City Tocumen Intl

17h 07m

2 stops

DSM8:22 amDes Moines

$465

Find similar

American Airlines

Oct 12

DSM6:07 pmDes Moines

19h 56m

2 stops

PTY2:03 pmPanama City Tocumen Intl

Oct 19

PTY3:15 pmPanama City Tocumen Intl

26h 27m

2 stops

DSM5:42 pmDes Moines

$471

Find similar

American Airlines

Jan 1

DSM6:00 amDes Moines

8h 54m

1 stop

PTY3:54 pmPanama City Tocumen Intl

Apr 1

PTY3:50 pmPanama City Tocumen Intl

30h 35m

1 stop

DSM10:25 pmDes Moines

$473

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 10/10

6:08 am-6:37 pm

1 stop12h 29m

Panama City Tocumen Intl

Fri 10/17

3:30 pm-2:13 pm

1 stop22h 43m

$449

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 10/10

6:08 am-6:37 pm

1 stop12h 29m

Panama City Tocumen Intl

Fri 10/17

3:30 pm-2:13 pm

1 stop22h 43m

$452

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 10/10

6:08 am-6:37 pm

1 stop12h 29m

Panama City Tocumen Intl

Fri 10/17

3:30 pm-2:13 pm

1 stop22h 43m

$456

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 10/8

5:42 pm-2:03 pm

2 stops20h 21m

Panama City Tocumen Intl

Wed 10/15

3:15 pm-8:22 am

2 stops17h 07m

$465

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/12

6:07 pm-2:03 pm

2 stops19h 56m

Panama City Tocumen Intl

Sun 10/19

3:15 pm-5:42 pm

2 stops26h 27m

$471

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 10/18

12:30 pm-12:56 pm

2 stops24h 26m

Panama City Tocumen Intl

Sat 10/25

2:21 pm-10:26 am

2 stops20h 05m

$491

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 10/16

6:39 pm-12:56 pm

1 stop18h 17m

Panama City Tocumen Intl

Sat 10/25

2:21 pm-10:30 pm

1 stop8h 09m

$513

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 10/9

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Thu 10/16

10:00 am-10:22 pm

1 stop12h 22m

$709

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 10/9

10:51 am-6:33 am

2 stops19h 42m

Panama City Tocumen Intl

Wed 10/15

3:20 am-5:14 pm

3 stops37h 54m

$766

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/12

4:39 pm-5:16 pm

3 stops24h 37m

Panama City Tocumen Intl

Sun 10/19

5:25 pm-5:01 pm

3 stops23h 36m

$767

Flights are sorted by cheapest round-trip flights first.

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How to get the cheapest flight ticket from Des Moines to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Panama City?

In general, December is the cheapest month to fly from Des Moines to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $402. If you’re not able to fly to Panama City in December, then September is your next best option. Flight prices from Des Moines to Panama City during September average around $441.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Sunday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $412. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $578. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from Des Moines to Panama City during this time can be as low as $439. Try not to purchase tickets in the morning because they tend to be around $539. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Des Moines to Panama City flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Panama City flight.

When to book flights from Des Moines to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Panama City (DSM to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City

Direct flights	None

There are no direct flights from Des Moines to Panama City. There are no popular flight routes from Des Moines to Panama City.

Search flight deals

How far is Des Moines to Panama City Tocumen Intl by plane?
The distance between Des Moines and Panama City Tocumen Intl is about 2409.5 mi. Flights usually cover this in 7h 09m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport?
Prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Panama City Tocumen Intl Airport?
As of August 2025, there are 3 operators available to choose from for flights from Des Moines Airport to Panama City Tocumen Intl Airport.
How old do you have to be to fly from Des Moines Airport to Panama City Tocumen Intl Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama City Tocumen Intl Airport.
What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?
The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Panama City?
Based on momondo bookings for flights between Des Moines and Panama City, the leading airline is United Airlines, making up 51% of the total bookings. Other popular airlines include Delta with 25% and American Airlines with 24%.

Best airlines flying from Des Moines to Panama City

Compare and see reviews for airlines that fly from Des Moines to Panama City with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $410	Free Cancellation	Rating 7.9 7,977 reviews	Search Delta flights
United Airlines	PriceFrom $411	Free Cancellation	Rating 7.4 8,944 reviews	Search United Airlines flights
American Airlines	PriceFrom $445	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights

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Why should I use momondo to find a flight deal from Des Moines to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Panama City for you.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Flights from Des Moines to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Panama City?

momondo helps you find the best flight between Des Moines and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Bocas Del Toro Airport

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David Enrique Malek Airport

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Cheap flights from Des Moines to Panama City from $198

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 10/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Find the cheapest flights from Des Moines to Panama City (DSM-PTY)

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United Airlines flights from Des Moines to Panama City

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American Airlines flights from Des Moines to Panama City

Our best American Airlines deals on Des Moines to Panama City flight tickets

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How to get the cheapest flight ticket from Des Moines to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

What is the cheapest day to depart on your flight to Panama City?

What is the cheapest time of day to depart on your flight to Panama City?

Can stopping save me money on Des Moines to Panama City flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Panama City flight.

What is the cheapest airline that flies from Des Moines to Panama City Tocumen Intl?

United Airlines is the most popular carrier operating from Des Moines to Panama City Tocumen Intl

What airlines fly to Panama City?

Which airport is the most popular layover for flights between Des Moines and Panama City?

Houston (IAH) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from Des Moines to Panama City?

Flights via Houston (IAH) offer the lowest average round-trip price of $495.

Which layover airport has the shortest travel time from Des Moines to Panama City?

Flights connecting via Atlanta (ATL) have the shortest average one-way travel time: 7h 09m.

Which layover airport has the shortest connection time from Des Moines to Panama City?

Atlanta (ATL) has the shortest average layover time for this route: 1h 14m.

When to book flights from Des Moines to Panama City

Cheap Des Moines to Panama City (DSM to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City

Direct flights

How far is Des Moines to Panama City Tocumen Intl by plane?

When did momondo last update prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

How many operators does momondo search for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

How old do you have to be to fly from Des Moines Airport to Panama City Tocumen Intl Airport?

What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

What is the most popular airline from Des Moines to Panama City?

Best airlines flying from Des Moines to Panama City

Compare and see reviews for airlines that fly from Des Moines to Panama City with momondo

Traveling to a place near Panama City?

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama City?

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

How can momondo help me find flights from Des Moines to Panama City?

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

An easier way to manage your Panama City trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Airports servicing Panama