What is the cheapest airline that flies from Des Moines to Panama City Tocumen Intl?

United Airlines is the most popular carrier operating from Des Moines to Panama City Tocumen Intl

When did momondo last update prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

Prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

As of October 2026, there is 1 operator available to choose from for flights from Des Moines Airport to Panama City Tocumen Intl Airport.

How old do you have to be to fly from Des Moines Airport to Panama City Tocumen Intl Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama City Tocumen Intl Airport.

What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$291 Cheap Flights from Des Moines to Panama City in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Panama City

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

10:30 am - 2:03 pmDSM Des Moines-PTY Panama City Tocumen Intl

26h 33m2 stops Detroit Metropolitan Wayne County Atlanta Hartsfield-Jackson

3:29 pm - 10:38 pmPTY Panama City Tocumen Intl-DSM Des Moines

8h 09m1 stop Atlanta Hartsfield-Jackson

$638Delta

Sun, Dec 6 - Tue, Dec 15

10:30 am - 2:03 pmDSM Des Moines-PTY Panama City Tocumen Intl

26h 33m2 stops Detroit Metropolitan Wayne County Atlanta Hartsfield-Jackson

3:29 pm - 4:49 pmPTY Panama City Tocumen Intl-DSM Des Moines

26h 20m2 stops Atlanta Hartsfield-Jackson Detroit Metropolitan Wayne County

$638Delta

Sun, Dec 6 - Tue, Dec 15

6:53 pm - 2:03 pmDSM Des Moines-PTY Panama City Tocumen Intl

18h 10m1 stop Atlanta Hartsfield-Jackson

3:29 pm - 10:38 pmPTY Panama City Tocumen Intl-DSM Des Moines

8h 09m1 stop Atlanta Hartsfield-Jackson

$638Delta

Sun, Dec 6 - Tue, Dec 15

8:00 am - 7:38 pmDSM Des Moines-PTY Panama City Tocumen Intl

10h 38m1 stop Houston George Bush Intcntl

11:35 am - 10:33 pmPTY Panama City Tocumen Intl-DSM Des Moines

11h 58m1 stop Houston George Bush Intcntl

$647United Airlines

Wed, Feb 3 - Thu, Feb 11

8:00 am - 5:12 pmDSM Des Moines-PTY Panama City Tocumen Intl

8h 12m1 stop Houston George Bush Intcntl

11:35 am - 10:30 pmPTY Panama City Tocumen Intl-DSM Des Moines

11h 55m1 stop Houston George Bush Intcntl

$647United Airlines

Tue, Feb 2 - Tue, Feb 9

8:00 am - 7:38 pmDSM Des Moines-PTY Panama City Tocumen Intl

10h 38m1 stop Houston George Bush Intcntl

11:35 am - 10:33 pmPTY Panama City Tocumen Intl-DSM Des Moines

11h 58m1 stop Houston George Bush Intcntl

$647United Airlines

Tue, Feb 2 - Thu, Feb 11

8:00 am - 5:12 pmDSM Des Moines-PTY Panama City Tocumen Intl

8h 12m1 stop Houston George Bush Intcntl

11:35 am - 10:30 pmPTY Panama City Tocumen Intl-DSM Des Moines

11h 55m1 stop Houston George Bush Intcntl

$647United Airlines

Wed, Feb 3 - Tue, Feb 9

8:00 am - 5:12 pmDSM Des Moines-PTY Panama City Tocumen Intl

8h 12m1 stop Houston George Bush Intcntl

11:35 am - 10:30 pmPTY Panama City Tocumen Intl-DSM Des Moines

11h 55m1 stop Houston George Bush Intcntl

$647United Airlines

Mon, Feb 1 - Tue, Feb 9

8:00 am - 5:12 pmDSM Des Moines-PTY Panama City Tocumen Intl

8h 12m1 stop Houston George Bush Intcntl

8:55 am - 10:33 pmPTY Panama City Tocumen Intl-DSM Des Moines

14h 38m1 stop Houston George Bush Intcntl

$647United Airlines

Thu, Feb 4 - Thu, Feb 11

8:00 am - 5:12 pmDSM Des Moines-PTY Panama City Tocumen Intl

8h 12m1 stop Houston George Bush Intcntl

11:35 am - 10:30 pmPTY Panama City Tocumen Intl-DSM Des Moines

11h 55m1 stop Houston George Bush Intcntl

$647United Airlines

Mon, Feb 1 - Wed, Feb 10

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Delta flights from Des Moines to Panama City

Our best Delta deals on Des Moines to Panama City flight tickets

Delta

Dec 6

DSM6:53 pmDes Moines

18h 10m

1 stop

PTY2:03 pmPanama City Tocumen Intl

Dec 15

PTY3:29 pmPanama City Tocumen Intl

8h 09m

1 stop

DSM10:38 pmDes Moines

$638

Delta

Jan 30

DSM10:55 amDes Moines

50h 00m

2 stops

PTY1:55 pmPanama City Tocumen Intl

Feb 11

PTY3:20 pmPanama City Tocumen Intl

26h 30m

2 stops

DSM4:50 pmDes Moines

$670

Delta

Feb 5

DSM4:00 pmDes Moines

20h 55m

2 stops

PTY1:55 pmPanama City Tocumen Intl

Feb 11

PTY3:20 pmPanama City Tocumen Intl

26h 30m

2 stops

DSM4:50 pmDes Moines

$686

United Airlines flights from Des Moines to Panama City

Our best United Airlines deals on Des Moines to Panama City flight tickets

United Airlines

Feb 2

DSM8:00 amDes Moines

8h 12m

1 stop

PTY5:12 pmPanama City Tocumen Intl

Feb 10

PTY11:35 amPanama City Tocumen Intl

11h 55m

1 stop

DSM10:30 pmDes Moines

$647

United Airlines

Feb 1

DSM8:00 amDes Moines

8h 12m

1 stop

PTY5:12 pmPanama City Tocumen Intl

Feb 9

PTY8:55 amPanama City Tocumen Intl

15h 19m

2 stops

DSM11:14 pmDes Moines

$652

United Airlines

Jan 31

DSM3:00 pmDes Moines

22h 45m

1 stop

PTY2:45 pmPanama City Tocumen Intl

Feb 9

PTY11:35 amPanama City Tocumen Intl

11h 55m

1 stop

DSM10:30 pmDes Moines

$658

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Sun 12/6

10:30 am-2:03 pm

2 stops26h 33m

Panama City Tocumen Intl

Tue 12/15

3:29 pm-10:38 pm

1 stop8h 09m

$638

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Sun 12/6

10:30 am-2:03 pm

2 stops26h 33m

Panama City Tocumen Intl

Tue 12/15

3:29 pm-4:49 pm

2 stops26h 20m

$638

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Sun 12/6

6:53 pm-2:03 pm

1 stop18h 10m

Panama City Tocumen Intl

Tue 12/15

3:29 pm-10:38 pm

1 stop8h 09m

$638

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Wed 2/3

8:00 am-7:38 pm

1 stop10h 38m

Panama City Tocumen Intl

Thu 2/11

11:35 am-10:33 pm

1 stop11h 58m

$647

Quickest round-trip

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Tue 2/2

8:00 am-5:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Tue 2/9

11:35 am-10:30 pm

1 stop11h 55m

$647

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Tue 2/2

8:00 am-7:38 pm

1 stop10h 38m

Panama City Tocumen Intl

Thu 2/11

11:35 am-10:33 pm

1 stop11h 58m

$647

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Wed 2/3

8:00 am-5:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Tue 2/9

11:35 am-10:30 pm

1 stop11h 55m

$647

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Mon 2/1

8:00 am-5:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Tue 2/9

11:35 am-10:30 pm

1 stop11h 55m

$647

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Thu 2/4

8:00 am-5:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Thu 2/11

8:55 am-10:33 pm

1 stop14h 38m

$647

Des MoinesPanama City

DSM Des Moines - PTY Panama City Tocumen Intl

DSMPTY

Des Moines

Mon 2/1

8:00 am-5:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Wed 2/10

11:35 am-10:30 pm

1 stop11h 55m

$647

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Panama City?

In general, August is the cheapest month to fly from Des Moines to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you’re not able to fly to Panama City in August, then May is your next best option. Flight prices from Des Moines to Panama City during May average around $0.

When to book flights from Des Moines to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Panama City (DSM to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City

Best Price Found	$291
Fastest flight time	10h 38m
Direct flights	None

The best one-way flight to Panama City from Des Moines in the past 72 hours is $291. The best round-trip flight deal from Des Moines to Panama City found on momondo in the last 72 hours is $638.

The fastest flight from Des Moines to Panama City takes 10h 38m

There are no direct flights from Des Moines to Panama City. There are no popular flight routes from Des Moines to Panama City.

Search flight deals

Frequently asked questions about flying from Des Moines to Panama City

How far is Des Moines to Panama City Tocumen Intl by plane?
The distance between Des Moines and Panama City Tocumen Intl is about 2409.5 mi. Flights usually cover this in 10h 38m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport?
Prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Panama City Tocumen Intl Airport?
As of October 2026, there is 1 operator available to choose from for flights from Des Moines Airport to Panama City Tocumen Intl Airport.
How old do you have to be to fly from Des Moines Airport to Panama City Tocumen Intl Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama City Tocumen Intl Airport.
What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?
The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Panama City?
Based on momondo bookings for flights between Des Moines and Panama City, the leading airline is United Airlines, making up 100% of the total bookings.

Best airlines flying from Des Moines to Panama City

Compare and see reviews for airlines that fly from Des Moines to Panama City with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $461	Free Cancellation	Rating 7.3 10,388 reviews		Search United Airlines flights

San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Panama City for you.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Flights from Des Moines to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Panama City?

momondo helps you find the best flight between Des Moines and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Airports servicing Panama

Puerto Piña Bahia Pinas Airport

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Changuinola Airport

David Enrique Malek Airport

Jaque Airport

Mulatupo Airport

Puerto Obaldia Airport

Playon Chico Airport

Cheap flights from Des Moines to Panama City from $291

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 1/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Delta flights from Des Moines to Panama City

Our best Delta deals on Des Moines to Panama City flight tickets

United Airlines flights from Des Moines to Panama City

Our best United Airlines deals on Des Moines to Panama City flight tickets

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How to get the cheapest flight ticket from Des Moines to Panama City

What is the cheapest month to fly to Panama City?

What is the cheapest airline that flies from Des Moines to Panama City Tocumen Intl?

When to book flights from Des Moines to Panama City

Cheap Des Moines to Panama City (DSM to PTY) flight deals and tips

Best Price Found

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Direct flights

Frequently asked questions about flying from Des Moines to Panama City

Best airlines flying from Des Moines to Panama City

Compare and see reviews for airlines that fly from Des Moines to Panama City with momondo

Traveling to a place near Panama City?

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An easier way to manage your Panama City trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to Panama

Airports servicing Panama

Fly your favorite airline to Panama City

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama City

List of cabin classes available on flights landing in Panama City. Availability may vary depending on flight origin and airline.

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Popular flights according to clicks in the last 7 days on momondo

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