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Cheap flights from Des Moines to Panama City from $209

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 4/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:15 am - 6:38 pm
DSM
-
PTY
11h 23m
1 stop
United Airlines Logo
7:55 am - 10:43 pm
PTY
-
DSM
14h 48m
1 stop
$474United Airlines
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
7:00 am - 2:20 pm
DSM
-
PTY
7h 20m
1 stop
American Airlines Logo
3:51 pm - 10:34 am
PTY
-
DSM
18h 43m
2 stops
$475American Airlines
Tue, Mar 24 - Tue, Mar 31
United Airlines Logo
6:12 am - 6:38 pm
DSM
-
PTY
12h 26m
1 stop
United Airlines Logo
7:55 am - 10:43 pm
PTY
-
DSM
14h 48m
1 stop
$483United Airlines
Sat, Mar 28 - Sat, Apr 18
United Airlines Logo
3:28 pm - 4:12 pm
DSM
-
PTY
24h 44m
2 stops
United Airlines Logo
3:30 pm - 12:29 pm
PTY
-
DSM
20h 59m
2 stops
$487United Airlines
Sat, Mar 28 - Sun, Apr 19
United Airlines Logo
7:52 am - 5:07 pm
DSM
-
PTY
8h 15m
1 stop
United Airlines Logo
4:41 pm - 10:20 pm
PTY
-
DSM
30h 39m
1 stop
$492United Airlines
Mon, Feb 23 - Thu, Feb 26
United Airlines Logo
6:55 pm - 5:07 pm
DSM
-
PTY
21h 12m
2 stops
United Airlines Logo
4:41 pm - 10:20 pm
PTY
-
DSM
30h 39m
1 stop
$497United Airlines
Mon, Feb 23 - Thu, Feb 26
United Airlines Logo
3:28 pm - 6:38 pm
DSM
-
PTY
27h 10m
2 stops
United Airlines Logo
7:55 am - 10:43 pm
PTY
-
DSM
14h 48m
1 stop
$503United Airlines
Thu, Mar 26 - Tue, Apr 21
American Airlines Logo
7:44 pm - 2:20 pm
DSM
-
PTY
18h 36m
2 stops
American Airlines Logo
3:51 pm - 10:34 am
PTY
-
DSM
18h 43m
2 stops
$507American Airlines
Tue, Mar 24 - Tue, Mar 31
United Airlines Logo
3:28 pm - 6:38 pm
DSM
-
PTY
27h 10m
2 stops
United Airlines Logo
3:30 pm - 2:22 pm
PTY
-
DSM
22h 52m
1 stop
$512United Airlines
Thu, Mar 26 - Thu, Apr 16
United Airlines Logo
8:20 am - 4:12 pm
DSM
-
PTY
7h 52m
1 stop
United Airlines Logo
7:55 am - 10:43 pm
PTY
-
DSM
14h 48m
1 stop
$515United Airlines
Wed, Apr 22 - Sun, Apr 26

United Airlines flights from Des Moines to Panama City

Our best United Airlines deals on Des Moines to Panama City flight tickets
United Airlines
Mar 24
DSM8:00 amDes Moines
10h 38m
2 stops
PTY6:38 pmPanama City Tocumen Intl
Mar 31
PTY7:55 amPanama City Tocumen Intl
14h 48m
1 stop
DSM10:43 pmDes Moines
$474
United Airlines
Mar 28
DSM6:12 amDes Moines
12h 26m
1 stop
PTY6:38 pmPanama City Tocumen Intl
Apr 17
PTY10:00 amPanama City Tocumen Intl
12h 43m
1 stop
DSM10:43 pmDes Moines
$483
United Airlines
Feb 9
DSM8:10 amDes Moines
10h 28m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Feb 25
PTY4:41 pmPanama City Tocumen Intl
22h 46m
2 stops
DSM2:27 pmDes Moines
$487

American Airlines flights from Des Moines to Panama City

Our best American Airlines deals on Des Moines to Panama City flight tickets
American Airlines
Mar 24
DSM7:00 amDes Moines
7h 20m
1 stop
PTY2:20 pmPanama City Tocumen Intl
Mar 31
PTY3:51 pmPanama City Tocumen Intl
18h 43m
2 stops
DSM10:34 amDes Moines
$475
American Airlines
Mar 24
DSM7:44 pmDes Moines
18h 36m
2 stops
PTY2:20 pmPanama City Tocumen Intl
Mar 31
PTY3:51 pmPanama City Tocumen Intl
18h 43m
2 stops
DSM10:34 amDes Moines
$507
American Airlines
Mar 23
DSM6:00 amDes Moines
8h 20m
1 stop
PTY2:20 pmPanama City Tocumen Intl
Mar 30
PTY3:51 pmPanama City Tocumen Intl
21h 16m
2 stops
DSM1:07 pmDes Moines
$558

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 3/24

7:15 am-6:38 pm

1 stop11h 23m

Panama City Tocumen Intl

Tue 3/31

7:55 am-10:43 pm

1 stop14h 48m

$474

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 3/24

7:00 am-2:20 pm

1 stop7h 20m

Panama City Tocumen Intl

Tue 3/31

3:51 pm-10:34 am

2 stops18h 43m

$475

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 3/28

6:12 am-6:38 pm

1 stop12h 26m

Panama City Tocumen Intl

Sat 4/18

7:55 am-10:43 pm

1 stop14h 48m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 3/28

3:28 pm-4:12 pm

2 stops24h 44m

Panama City Tocumen Intl

Sun 4/19

3:30 pm-12:29 pm

2 stops20h 59m

$487

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 2/23

7:52 am-5:07 pm

1 stop8h 15m

Panama City Tocumen Intl

Thu 2/26

4:41 pm-10:20 pm

1 stop30h 39m

$492

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 2/23

6:55 pm-5:07 pm

2 stops21h 12m

Panama City Tocumen Intl

Thu 2/26

4:41 pm-10:20 pm

1 stop30h 39m

$497

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 3/26

3:28 pm-6:38 pm

2 stops27h 10m

Panama City Tocumen Intl

Tue 4/21

7:55 am-10:43 pm

1 stop14h 48m

$503

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 3/24

7:44 pm-2:20 pm

2 stops18h 36m

Panama City Tocumen Intl

Tue 3/31

3:51 pm-10:34 am

2 stops18h 43m

$507

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 3/26

3:28 pm-6:38 pm

2 stops27h 10m

Panama City Tocumen Intl

Thu 4/16

3:30 pm-2:22 pm

1 stop22h 52m

$512

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 4/22

8:20 am-4:12 pm

1 stop7h 52m

Panama City Tocumen Intl

Sun 4/26

7:55 am-10:43 pm

1 stop14h 48m

$515

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Des Moines to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, September is the cheapest month to fly from Des Moines to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $441. If you’re not able to fly to Panama City in September, then January is your next best option. Flight prices from Des Moines to Panama City during January average around $453.

Can stopping save me money on Des Moines to Panama City flights?

You could potentially save up to 13% on your flight if you consider stops on a Des Moines to Panama City flight.

When to book flights from Des Moines to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Panama City (DSM to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City

Fastest flight time

7h 57m

Direct flights

None
The fastest flight from Des Moines to Panama City takes 7h 57m
There are no direct flights from Des Moines to Panama City. There are no popular flight routes from Des Moines to Panama City.
Search flight deals

  • How far is Des Moines to Panama City Tocumen Intl by plane?

    The distance between Des Moines and Panama City Tocumen Intl is about 2409.5 mi. Flights usually cover this in 7h 57m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Panama City Tocumen Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Panama City?

Best airlines flying from Des Moines to Panama City

Compare and see reviews for airlines that fly from Des Moines to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $441Free CancellationRating
7.4
9,254 reviews
Search United Airlines flights
DeltaPriceFrom $441Free CancellationRating
7.9
8,172 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Panama City for you.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Flights from Des Moines to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Panama City?

momondo helps you find the best flight between Des Moines and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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