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Cheap flights from Des Moines to Panama City from $312

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Panama City departing on 1/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:52 pm - 8:50 am
DSM
-
PTY
12h 58m
2 stops
Multiple Airlines Logo
9:45 am - 11:40 pm
PTY
-
DSM
14h 55m
2 stops
$665Multiple Airlines
Thu, Nov 26 - Tue, Dec 8
Multiple Airlines Logo
6:52 pm - 8:50 am
DSM
-
PTY
12h 58m
2 stops
Multiple Airlines Logo
9:45 am - 11:40 pm
PTY
-
DSM
14h 55m
2 stops
$689Multiple Airlines
Sat, Nov 28 - Fri, Dec 11
Multiple Airlines Logo
3:20 pm - 9:15 am
DSM
-
PTY
17h 55m
2 stops
Multiple Airlines Logo
5:30 am - 10:30 pm
PTY
-
DSM
17h 00m
2 stops
$690Multiple Airlines
Tue, Sep 1 - Sat, Sep 5
Delta Logo
5:45 am - 2:05 pm
DSM
-
PTY
7h 20m
1 stop
Delta Logo
3:30 pm - 10:29 pm
PTY
-
DSM
7h 59m
1 stop
$693Delta
Thu, Nov 26 - Thu, Dec 10
United Airlines Logo
6:21 am - 8:02 pm
DSM
-
PTY
12h 41m
2 stops
United Airlines Logo
11:35 am - 11:01 pm
PTY
-
DSM
12h 26m
2 stops
$697United Airlines
Thu, Nov 26 - Mon, Dec 14
American Airlines Logo
5:10 pm - 12:39 pm
DSM
-
PTY
19h 29m
2 stops
American Airlines Logo
1:16 pm - 8:39 am
PTY
-
DSM
19h 23m
2 stops
$703American Airlines
Wed, Sep 2 - Wed, Sep 9
Delta Logo
6:30 pm - 2:05 pm
DSM
-
PTY
18h 35m
1 stop
Delta Logo
3:30 pm - 10:29 pm
PTY
-
DSM
7h 59m
1 stop
$704Delta
Wed, Nov 25 - Tue, Dec 8
Delta Logo
5:45 am - 2:05 pm
DSM
-
PTY
7h 20m
1 stop
Delta Logo
3:30 pm - 10:29 pm
PTY
-
DSM
7h 59m
1 stop
$708Delta
Fri, Nov 27 - Wed, Dec 9
Delta Logo
5:45 am - 2:05 pm
DSM
-
PTY
7h 20m
1 stop
Delta Logo
3:30 pm - 9:24 am
PTY
-
DSM
18h 54m
2 stops
$712Delta
Fri, Nov 27 - Thu, Dec 10
Delta Logo
6:30 pm - 2:05 pm
DSM
-
PTY
18h 35m
1 stop
Delta Logo
3:30 pm - 10:29 pm
PTY
-
DSM
7h 59m
1 stop
$719Delta
Wed, Nov 25 - Fri, Dec 11

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American Airlines flights from Des Moines to Panama City

Our best American Airlines deals on Des Moines to Panama City flight tickets
American Airlines
Sep 2
DSM5:10 pmDes Moines
19h 29m
2 stops
PTY12:39 pmPanama City Tocumen Intl
Sep 9
PTY1:16 pmPanama City Tocumen Intl
19h 23m
2 stops
DSM8:39 amDes Moines
$703
American Airlines
Nov 28
DSM6:00 amDes Moines
30h 36m
1 stop
PTY1:36 pmPanama City Tocumen Intl
Dec 11
PTY2:50 pmPanama City Tocumen Intl
19h 04m
2 stops
DSM8:54 amDes Moines
$784
American Airlines
Sep 1
DSM4:13 pmDes Moines
20h 26m
2 stops
PTY12:39 pmPanama City Tocumen Intl
Sep 8
PTY1:39 pmPanama City Tocumen Intl
22h 52m
2 stops
DSM12:31 pmDes Moines
$791

United Airlines flights from Des Moines to Panama City

Our best United Airlines deals on Des Moines to Panama City flight tickets
United Airlines
Nov 26
DSM6:21 amDes Moines
12h 41m
2 stops
PTY8:02 pmPanama City Tocumen Intl
Dec 9
PTY11:35 amPanama City Tocumen Intl
11h 55m
1 stop
DSM10:30 pmDes Moines
$697
United Airlines
Sep 1
DSM6:15 amDes Moines
12h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Sep 6
PTY10:00 amPanama City Tocumen Intl
10h 24m
1 stop
DSM8:24 pmDes Moines
$723
United Airlines
Nov 26
DSM6:21 amDes Moines
12h 41m
2 stops
PTY8:02 pmPanama City Tocumen Intl
Dec 13
PTY4:41 pmPanama City Tocumen Intl
22h 39m
1 stop
DSM2:20 pmDes Moines
$724

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 20, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 11/26

6:52 pm-8:50 am

2 stops12h 58m

Panama City Tocumen Intl

Tue 12/8

9:45 am-11:40 pm

2 stops14h 55m

$665

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 11/28

6:52 pm-8:50 am

2 stops12h 58m

Panama City Tocumen Intl

Fri 12/11

9:45 am-11:40 pm

2 stops14h 55m

$689

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 9/1

3:20 pm-9:15 am

2 stops17h 55m

Panama City Tocumen Intl

Sat 9/5

5:30 am-10:30 pm

2 stops17h 00m

$690
Quickest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 11/26

5:45 am-2:05 pm

1 stop7h 20m

Panama City Tocumen Intl

Thu 12/10

3:30 pm-10:29 pm

1 stop7h 59m

$693

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 11/26

6:21 am-8:02 pm

2 stops12h 41m

Panama City Tocumen Intl

Mon 12/14

11:35 am-11:01 pm

2 stops12h 26m

$697

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 9/2

5:10 pm-12:39 pm

2 stops19h 29m

Panama City Tocumen Intl

Wed 9/9

1:16 pm-8:39 am

2 stops19h 23m

$703

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 11/25

6:30 pm-2:05 pm

1 stop18h 35m

Panama City Tocumen Intl

Tue 12/8

3:30 pm-10:29 pm

1 stop7h 59m

$704

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 11/27

5:45 am-2:05 pm

1 stop7h 20m

Panama City Tocumen Intl

Wed 12/9

3:30 pm-10:29 pm

1 stop7h 59m

$708

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 11/27

5:45 am-2:05 pm

1 stop7h 20m

Panama City Tocumen Intl

Thu 12/10

3:30 pm-9:24 am

2 stops18h 54m

$712

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 11/25

6:30 pm-2:05 pm

1 stop18h 35m

Panama City Tocumen Intl

Fri 12/11

3:30 pm-10:29 pm

1 stop7h 59m

$719

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Des Moines to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, May is the cheapest month to fly from Des Moines to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $461. If you’re not able to fly to Panama City in May, then February is your next best option. Flight prices from Des Moines to Panama City during February average around $461.

When to book flights from Des Moines to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Panama City (DSM to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Panama City

Fastest flight time

7h 15m

Direct flights

None
The fastest flight from Des Moines to Panama City takes 7h 15m
There are no direct flights from Des Moines to Panama City. There are no popular flight routes from Des Moines to Panama City.
Search flight deals

Frequently asked questions about flying from Des Moines to Panama City

  • How far is Des Moines to Panama City Tocumen Intl by plane?

    The distance between Des Moines and Panama City Tocumen Intl is about 2409.5 mi. Flights usually cover this in 7h 15m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Des Moines Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Panama City Tocumen Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Panama City?

Best airlines flying from Des Moines to Panama City

Compare and see reviews for airlines that fly from Des Moines to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $461Free CancellationRating
7.4
10,013 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Panama City for you.

Can I find flights from Des Moines to Panama City with flexible booking policies on momondo?

Flights from Des Moines to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Panama City?

momondo helps you find the best flight between Des Moines and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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