Cheap flights from Chicago to Brussels from $268

The cheapest month to fly to Brussels Bruxelles-National Airport from Chicago is in May. Flight prices, which tend to average around $129, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of May, then book flights to Brussels Bruxelles-National Airport from Chicago during April instead. Flights to Brussels Bruxelles-National Airport in April, while not as cheap as those in May, still average around $418.

The cheapest day to depart from Chicago to Brussels Bruxelles-National Airport is on a Tuesday. Travelers who choose to depart for Brussels Bruxelles-National Airport on a Tuesday will often find tickets for as low as $1,091. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Chicago to Brussels Bruxelles-National Airport for around $1,396.

Our most recent data shows that the best time of day to fly to Brussels Bruxelles-National Airport is in the evening. Flights from Chicago to Brussels Bruxelles-National Airport during this time can be as low as $1,233. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $1,267 on average. Flights to Brussels Bruxelles-National Airport from Chicago in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from Chicago O'Hare Intl to Brussels Bruxelles-National for the best Chicago - Brussels Bruxelles-National flight prices

You are more likely to see cheaper flights to Brussels Bruxelles-National Airport from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Brussels Bruxelles-National Airport for around $856 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Brussels Bruxelles-National Airport from Chicago for as low as $572 on momondo.

There are 3 cabin classes available to choose from on Chicago to Brussels Bruxelles-National Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Dublin (DUB) was the most common stop: 36% of momondo users choosing 1-stop flights on this route connected there.

Flights via Reykjavik (KEF) offer the lowest average round-trip price of $534.

Flights connecting via Reykjavik (KEF) have the shortest average one-way travel time: 10h 27m.

Reykjavik (KEF) has the shortest average layover time for this route: 1h 03m.

As of July 2026, there are 5 flights per day flying from Chicago to Brussels Bruxelles-National Airport. The most common time of day flights depart is 6:00PM, with 100% of flights taking off in the evening.

The number of flights available between Chicago and Brussels Bruxelles-National Airport is 35 per week as of July 2026. The most frequent departure day is Mon, with 14% of weekly flights leaving on this day.