Cheap flights from Chicago to Brussels from $350

The cheapest month to fly to Brussels Bruxelles-National Airport from Chicago is in April. Flight prices, which tend to average around $635, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of April, then book flights to Brussels Bruxelles-National Airport from Chicago during February instead. Flights to Brussels Bruxelles-National Airport in February, while not as cheap as those in April, still average around $654.

The cheapest day to depart from Chicago to Brussels Bruxelles-National Airport is on a Tuesday. Travelers who choose to depart for Brussels Bruxelles-National Airport on a Tuesday will often find tickets for as low as $1,139. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Chicago to Brussels Bruxelles-National Airport for around $1,439.

Our most recent data shows that the best time of day to fly to Brussels Bruxelles-National Airport is in the evening. Flights from Chicago to Brussels Bruxelles-National Airport during this time can be as low as $1,234. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $1,326 on average. Flights to Brussels Bruxelles-National Airport from Chicago in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from Chicago O'Hare Intl to Brussels Bruxelles-National for the best Chicago - Brussels Bruxelles-National flight prices

You are more likely to see cheaper flights to Brussels Bruxelles-National Airport from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Brussels Bruxelles-National Airport for around $906 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Brussels Bruxelles-National Airport from Chicago for as low as $591 on momondo.

There are 3 cabin classes available to choose from on Chicago to Brussels Bruxelles-National Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 16% on your flight if you consider stops on a Chicago to Brussels Bruxelles-National Airport flight.

Turkish Airlines and Delta are the most popular carriers operating from Chicago to Brussels Bruxelles-National

Scandinavian Airlines, United Airlines and Icelandair are the top three most popular airlines that fly to Brussels Bruxelles-National Airport from Chicago according to our data. Scandinavian Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Brussels Bruxelles-National Airport. Keep in mind that there are 7 different airlines that fly to Brussels Bruxelles-National Airport on a routine basis, so you have a few additional options to choose from.

Dublin (DUB) was the most common stop: 31% of momondo users choosing 1-stop flights on this route connected there.

Flights via Dublin (DUB) offer the lowest average round-trip price of $612.

Flights connecting via Reykjavik (KEF) have the shortest average one-way travel time: 10h 29m.

Reykjavik (KEF) has the shortest average layover time for this route: 1h 04m.

As of October 2026, there are 5 flights per day flying from Chicago to Brussels Bruxelles-National Airport. The most common time of day flights depart is 6:00PM, with 100% of flights taking off in the evening.

The number of flights available between Chicago and Brussels Bruxelles-National Airport is 35 per week as of October 2026. The most frequent departure day is Mon, with 14% of weekly flights leaving on this day.