Cheap flights from Chicago to Brussels from $353

In general, May is the cheapest month to fly from Chicago to Brussels. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $129. If you are unable to visit Brussels during the month of May, then departing from Chicago during the month November is also very affordable. Most momondo users find prices during this month for around $328.

On average, the least expensive day to fly to Brussels from Chicago is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $1,051. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Saturday is the most expensive day to depart from Chicago because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $1,363.

Fly from Chicago O'Hare Intl to Brussels Bruxelles-National for the best Chicago - Brussels flight prices

You are more likely to see cheaper flights to Brussels from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Brussels for around $784 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Brussels from Chicago for as low as $477 on momondo.

As of May 2026, there are 5 flights per day flying from Chicago to Brussels. The most common time of day flights depart is 6:00PM, with 100% of flights taking off in the evening.

As of May 2026, 35 flights take off from Chicago and land in Brussels each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.