Cheap flights from Chicago to Brussels from $250

In general, April is the cheapest month to fly from Chicago to Brussels. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $647. If you are unable to visit Brussels during the month of April, then departing from Chicago during the month November is also very affordable. Most momondo users find prices during this month for around $663.

On average, the least expensive day to fly to Brussels from Chicago is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $1,135. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Saturday is the most expensive day to depart from Chicago because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $1,437.

According to our data, the cheapest time of day to fly to Brussels is in the evening. momondo users have found flights departing from Chicago to Brussels in the evening for as low as $1,233. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights in the afternoon are often more expensive with an average ticket price of $1,287.

Fly from Chicago O'Hare Intl to Brussels Bruxelles-National for the best Chicago - Brussels flight prices

You are more likely to see cheaper flights to Brussels from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Brussels for around $847 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Brussels from Chicago for as low as $591 on momondo.

There are 3 cabin classes available to choose from on Chicago to Brussels flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Icelandair and Turkish Airlines are the most popular carriers operating from Chicago to Brussels

Scandinavian Airlines, United Airlines and Icelandair are the top three most popular airlines that fly to Brussels from Chicago according to our data. Scandinavian Airlines is the first choice among our users, with 33% of people opting to fly with this airline when traveling to Brussels. Keep in mind that there are 7 different airlines that fly to Brussels on a routine basis, so you have a few additional options to choose from.

As of August 2026, there are 5 flights per day flying from Chicago to Brussels. The most common time of day flights depart is 6:00PM, with 100% of flights taking off in the evening.

As of August 2026, 35 flights take off from Chicago and land in Brussels each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.