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Cheap flights from Charleston to Santiago de los Caballeros from $379

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Santiago de los Caballeros departing on 5/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Charleston to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
11:00 am - 11:56 pm
CHS
-
STI
12h 56m
1 stop
JetBlue Logo
8:31 am - 7:13 pm
STI
-
CHS
10h 42m
1 stop
$379JetBlue
Thu, May 7 - Mon, May 11
American Airlines Logo
6:20 pm - 12:23 pm
CHS
-
STI
18h 03m
2 stops
American Airlines Logo
1:32 pm - 11:12 am
STI
-
CHS
21h 40m
2 stops
$387American Airlines
Sat, May 16 - Mon, May 18
American Airlines Logo
4:46 pm - 12:23 pm
CHS
-
STI
19h 37m
2 stops
American Airlines Logo
1:32 pm - 8:31 am
STI
-
CHS
18h 59m
2 stops
$392American Airlines
Fri, May 15 - Sun, May 17
JetBlue Logo
5:59 pm - 1:35 am
CHS
-
STI
7h 36m
1 stop
JetBlue Logo
6:00 am - 4:57 pm
STI
-
CHS
10h 57m
1 stop
$395JetBlue
Fri, May 15 - Sun, May 17
American Airlines Logo
1:18 pm - 12:23 pm
CHS
-
STI
23h 05m
1 stop
American Airlines Logo
1:32 pm - 10:34 am
STI
-
CHS
21h 02m
1 stop
$399American Airlines
Sat, May 16 - Mon, May 18
American Airlines Logo
4:46 pm - 12:23 pm
CHS
-
STI
19h 37m
2 stops
American Airlines Logo
1:32 pm - 10:34 am
STI
-
CHS
21h 02m
1 stop
$400American Airlines
Fri, May 15 - Sun, May 17
Delta Logo
5:55 pm - 12:59 am
CHS
-
STI
7h 04m
1 stop
Delta Logo
8:59 pm - 12:12 pm
STI
-
CHS
15h 13m
1 stop
$403Delta
Sat, May 16 - Mon, May 18
JetBlue Logo
5:59 pm - 1:35 am
CHS
-
STI
7h 36m
1 stop
JetBlue Logo
6:00 am - 4:57 pm
STI
-
CHS
10h 57m
1 stop
$412JetBlue
Sat, May 16 - Mon, May 18
Delta Logo
6:00 am - 7:28 pm
CHS
-
STI
13h 28m
1 stop
Delta Logo
8:50 pm - 11:24 am
STI
-
CHS
14h 34m
2 stops
$413Delta
Fri, Jun 5 - Tue, Jun 9
JetBlue Logo
11:00 am - 10:26 pm
CHS
-
STI
11h 26m
1 stop
JetBlue Logo
8:31 am - 7:13 pm
STI
-
CHS
10h 42m
1 stop
$416JetBlue
Sat, May 9 - Wed, May 13

Spirit Airlines flights from Charleston to Santiago de los Caballeros

Our best Spirit Airlines deals on Charleston to Santiago de los Caballeros flight tickets
Spirit Airlines
Mar 27
CHS8:07 amCharleston
6h 28m
1 stop
STI2:35 pmSantiago de los Caballeros
Apr 7
STI3:28 pmSantiago de los Caballeros
6h 45m
1 stop
CHS10:13 pmCharleston
$369
Spirit Airlines
Apr 2
CHS8:07 amCharleston
6h 16m
1 stop
STI2:23 pmSantiago de los Caballeros
Apr 7
STI3:28 pmSantiago de los Caballeros
6h 45m
1 stop
CHS10:13 pmCharleston
$460
Spirit Airlines
Mar 27
CHS8:07 amCharleston
6h 28m
1 stop
STI2:35 pmSantiago de los Caballeros
Apr 7
STI3:28 pmSantiago de los Caballeros
19h 41m
3 stops
CHS11:09 amCharleston
$506

Delta flights from Charleston to Santiago de los Caballeros

Our best Delta deals on Charleston to Santiago de los Caballeros flight tickets
Delta
May 16
CHS5:55 pmCharleston
7h 04m
1 stop
STI12:59 amSantiago de los Caballeros
May 18
STI8:59 pmSantiago de los Caballeros
15h 13m
1 stop
CHS12:12 pmCharleston
$403
Delta
Jun 5
CHS6:00 amCharleston
13h 28m
1 stop
STI7:28 pmSantiago de los Caballeros
Jun 9
STI8:50 pmSantiago de los Caballeros
14h 34m
2 stops
CHS11:24 amCharleston
$413
Delta
May 15
CHS6:00 amCharleston
13h 28m
1 stop
STI7:28 pmSantiago de los Caballeros
May 17
STI8:59 pmSantiago de los Caballeros
18h 50m
2 stops
CHS3:49 pmCharleston
$433

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Charleston to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Thu 5/7

11:00 am-11:56 pm

1 stop12h 56m

Santiago de los Caballeros

Mon 5/11

8:31 am-7:13 pm

1 stop10h 42m

$379

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Sat 5/16

6:20 pm-12:23 pm

2 stops18h 03m

Santiago de los Caballeros

Mon 5/18

1:32 pm-11:12 am

2 stops21h 40m

$387

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Fri 5/15

4:46 pm-12:23 pm

2 stops19h 37m

Santiago de los Caballeros

Sun 5/17

1:32 pm-8:31 am

2 stops18h 59m

$392
Quickest round-trip

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Fri 5/15

5:59 pm-1:35 am

1 stop7h 36m

Santiago de los Caballeros

Sun 5/17

6:00 am-4:57 pm

1 stop10h 57m

$395

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Sat 5/16

1:18 pm-12:23 pm

1 stop23h 05m

Santiago de los Caballeros

Mon 5/18

1:32 pm-10:34 am

1 stop21h 02m

$399

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Fri 5/15

4:46 pm-12:23 pm

2 stops19h 37m

Santiago de los Caballeros

Sun 5/17

1:32 pm-10:34 am

1 stop21h 02m

$400

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Sat 5/16

5:55 pm-12:59 am

1 stop7h 04m

Santiago de los Caballeros

Mon 5/18

8:59 pm-12:12 pm

1 stop15h 13m

$403

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Sat 5/16

5:59 pm-1:35 am

1 stop7h 36m

Santiago de los Caballeros

Mon 5/18

6:00 am-4:57 pm

1 stop10h 57m

$412

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Fri 6/5

6:00 am-7:28 pm

1 stop13h 28m

Santiago de los Caballeros

Tue 6/9

8:50 pm-11:24 am

2 stops14h 34m

$413

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Sat 5/9

11:00 am-10:26 pm

1 stop11h 26m

Santiago de los Caballeros

Wed 5/13

8:31 am-7:13 pm

1 stop10h 42m

$416

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from Charleston to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Charleston to Santiago de los Caballeros flights?

You could potentially save up to 33% on your flight if you consider stops on a Charleston to Santiago de los Caballeros flight.

When to book flights from Charleston to Santiago de los Caballeros

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Santiago de los Caballeros according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Santiago de los Caballeros (CHS to STI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Santiago de los Caballeros

Fastest flight time

6h 16m

Direct flights

None
The fastest flight from Charleston to Santiago de los Caballeros takes 6h 16m
There are no direct flights from Charleston to Santiago de los Caballeros. There are no popular flight routes from Charleston to Santiago de los Caballeros.
Search flight deals

  • How far is Charleston to Santiago de los Caballeros by plane?

    Charleston and Santiago de los Caballeros are 1082.3 mi apart from one another. In terms of flight time, this usually takes a little over 6h 16m.

  • When did momondo last update prices for flights from Charleston Airport to Santiago de los Caballeros Airport?

    Prices for flights from Charleston Airport to Santiago de los Caballeros Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charleston Airport to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from Charleston Airport to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The required travel and health documents for your Santiago de los Caballeros Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago de los Caballeros Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Charleston to Santiago de los Caballeros?

Best airlines flying from Charleston to Santiago de los Caballeros

Compare and see reviews for airlines that fly from Charleston to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $438Free CancellationRating
7.1
11,468 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Santiago de los Caballeros?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Charleston to Santiago de los Caballeros for you.

Can I find flights from Charleston to Santiago de los Caballeros with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago de los Caballeros from Charleston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Charleston to Santiago de los Caballeros?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago de los Caballeros from Charleston.

I’m not ready to book a flight from Charleston to Santiago de los Caballeros right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charleston to Santiago de los Caballeros now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago de los Caballeros and let you know when they change.

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