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Cheap flights from Charleston to Santiago de los Caballeros from $175

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Santiago de los Caballeros departing on 1/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Charleston to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 12:13 pmCHS-STI
6h 13m1 stop
American Airlines Logo
1:14 pm - 11:59 pmSTI-CHS
10h 45m1 stop
$345American Airlines
Find Deal
Mon, Oct 27 - Fri, Oct 31
American Airlines Logo
5:00 am - 12:13 pmCHS-STI
7h 13m2 stops
American Airlines Logo
1:14 pm - 7:04 pmSTI-CHS
5h 50m1 stop
$350American Airlines
Find Deal
Mon, Oct 27 - Fri, Oct 31
JetBlue Logo
6:19 pm - 2:26 amCHS-STI
8h 07m1 stop
JetBlue Logo
9:00 am - 3:48 pmSTI-CHS
6h 48m1 stop
$369JetBlue
Find Deal
Mon, Mar 9 - Wed, Mar 11
Delta Logo
12:15 pm - 11:27 pmCHS-STI
11h 12m2 stops
Delta Logo
6:00 am - 4:47 pmSTI-CHS
10h 47m1 stop
$375Delta
Find Deal
Mon, Mar 9 - Wed, Mar 11
JetBlue Logo
6:19 pm - 2:26 amCHS-STI
8h 07m1 stop
JetBlue Logo
3:51 am - 5:22 pmSTI-CHS
13h 31m1 stop
$391JetBlue
Find Deal
Mon, Mar 9 - Tue, Mar 10
Delta Logo
12:15 pm - 11:27 pmCHS-STI
11h 12m2 stops
Delta Logo
6:00 am - 4:49 pmSTI-CHS
10h 49m2 stops
$398Delta
Find Deal
Mon, Mar 9 - Wed, Mar 11
Delta Logo
6:00 am - 6:16 pmCHS-STI
12h 16m1 stop
Delta Logo
6:00 am - 4:49 pmSTI-CHS
10h 49m2 stops
$400Delta
Find Deal
Mon, Mar 9 - Wed, Mar 11
Delta Logo
12:15 pm - 11:27 pmCHS-STI
11h 12m2 stops
Delta Logo
6:00 am - 4:49 pmSTI-CHS
10h 49m2 stops
$448Delta
Find Deal
Mon, Mar 9 - Wed, Mar 11
Spirit Airlines Logo
11:40 am - 5:06 pmCHS-STI
28h 26m3 stops
Spirit Airlines Logo
6:18 pm - 8:34 amSTI-CHS
39h 16m3 stops
$1,200Spirit Airlines
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Tue, Dec 23 - Tue, Dec 30
Spirit Airlines Logo
11:40 am - 5:06 pmCHS-STI
28h 26m3 stops
Spirit Airlines Logo
6:18 pm - 4:45 pmSTI-CHS
23h 27m2 stops
$1,251Spirit Airlines
Find Deal
Tue, Dec 23 - Tue, Dec 30

American Airlines flights from Charleston to Santiago de los Caballeros

Our best American Airlines deals on Charleston to Santiago de los Caballeros flight tickets
American Airlines
Oct 27
CHS6:00 amCharleston
6h 13m
1 stop
STI12:13 pmSantiago de los Caballeros
Oct 31
STI1:14 pmSantiago de los Caballeros
10h 45m
1 stop
CHS11:59 pmCharleston
$345
Find similar
American Airlines
Oct 27
CHS5:00 amCharleston
7h 13m
2 stops
STI12:13 pmSantiago de los Caballeros
Oct 31
STI1:14 pmSantiago de los Caballeros
5h 50m
1 stop
CHS7:04 pmCharleston
$350
Find similar
American Airlines
Oct 4
CHS7:28 pmCharleston
16h 59m
2 stops
STI12:27 pmSantiago de los Caballeros
Oct 10
STI1:14 pmSantiago de los Caballeros
10h 45m
1 stop
CHS11:59 pmCharleston
$455
Find similar

JetBlue flights from Charleston to Santiago de los Caballeros

Our best JetBlue deals on Charleston to Santiago de los Caballeros flight tickets
JetBlue
Mar 9
CHS6:19 pmCharleston
8h 07m
1 stop
STI2:26 amSantiago de los Caballeros
Mar 11
STI9:00 amSantiago de los Caballeros
6h 48m
1 stop
CHS3:48 pmCharleston
$369
Find similar
JetBlue
Mar 9
CHS6:19 pmCharleston
8h 07m
1 stop
STI2:26 amSantiago de los Caballeros
Mar 10
STI3:51 amSantiago de los Caballeros
13h 31m
1 stop
CHS5:22 pmCharleston
$391
Find similar
JetBlue
Oct 27
CHS6:05 amCharleston
8h 33m
1 stop
STI2:38 pmSantiago de los Caballeros
Oct 30
STI3:43 amSantiago de los Caballeros
9h 36m
1 stop
CHS1:19 pmCharleston
$542
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momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 1, 2025.
Use the filters below to find and compare flights from Charleston to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Mon 10/27

6:00 am-12:13 pm

1 stop6h 13m

Santiago de los Caballeros

Fri 10/31

1:14 pm-11:59 pm

1 stop10h 45m

$345

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Mon 10/27

5:00 am-12:13 pm

2 stops7h 13m

Santiago de los Caballeros

Fri 10/31

1:14 pm-7:04 pm

1 stop5h 50m

$350

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Mon 3/9

6:19 pm-2:26 am

1 stop8h 07m

Santiago de los Caballeros

Wed 3/11

9:00 am-3:48 pm

1 stop6h 48m

$369

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Mon 3/9

12:15 pm-11:27 pm

2 stops11h 12m

Santiago de los Caballeros

Wed 3/11

6:00 am-4:47 pm

1 stop10h 47m

$375

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Mon 3/9

6:19 pm-2:26 am

1 stop8h 07m

Santiago de los Caballeros

Tue 3/10

3:51 am-5:22 pm

1 stop13h 31m

$391

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Mon 3/9

12:15 pm-11:27 pm

2 stops11h 12m

Santiago de los Caballeros

Wed 3/11

6:00 am-4:49 pm

2 stops10h 49m

$398

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Mon 3/9

6:00 am-6:16 pm

1 stop12h 16m

Santiago de los Caballeros

Wed 3/11

6:00 am-4:49 pm

2 stops10h 49m

$400

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Mon 3/9

12:15 pm-11:27 pm

2 stops11h 12m

Santiago de los Caballeros

Wed 3/11

6:00 am-4:49 pm

2 stops10h 49m

$448

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Tue 12/23

11:40 am-5:06 pm

3 stops28h 26m

Santiago de los Caballeros

Tue 12/30

6:18 pm-8:34 am

3 stops39h 16m

$1,200

CharlestonSantiago de los Caballeros

CHS - STI

CHSSTI

Charleston

Tue 12/23

11:40 am-5:06 pm

3 stops28h 26m

Santiago de los Caballeros

Tue 12/30

6:18 pm-4:45 pm

2 stops23h 27m

$1,251

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from Charleston to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Charleston and Santiago de los Caballeros?

What is the cheapest day to depart on your flight to Santiago de los Caballeros?

The cheapest day to depart from Charleston to Santiago de los Caballeros is on a Saturday when prices can be found for as low as $501. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Charleston to Santiago de los Caballeros for around $946.

What is the cheapest time of day to depart on your flight to Santiago de los Caballeros?

Our data shows that the cheapest Charleston to Santiago de los Caballeros flights are usually those with departure times in the afternoon. Our users have found flights to Santiago de los Caballeros in the afternoon for as low as $386. In the morning is when there is more demand to fly to Santiago de los Caballeros, so prices are often more expensive at around $585 per ticket.

When to book flights from Charleston to Santiago de los Caballeros

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Santiago de los Caballeros according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Santiago de los Caballeros (CHS to STI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Santiago de los Caballeros

Direct flights

None
There are no direct flights from Charleston to Santiago de los Caballeros. There are no popular flight routes from Charleston to Santiago de los Caballeros.
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  • How far is Charleston to Santiago de los Caballeros by plane?

    Charleston and Santiago de los Caballeros are 1082.3 mi apart from one another. In terms of flight time, this usually takes a little over 6h 13m.

  • When did momondo last update prices for flights from Charleston Airport to Santiago de los Caballeros Airport?

    Prices for flights from Charleston Airport to Santiago de los Caballeros Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charleston Airport to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from Charleston Airport to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The required travel and health documents for your Santiago de los Caballeros Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago de los Caballeros Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Charleston to Santiago de los Caballeros?

Best airlines flying from Charleston to Santiago de los Caballeros

Compare and see reviews for airlines that fly from Charleston to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $371Free CancellationRating
7.2
2,912 reviews
Search JetBlue flights
American AirlinesPriceFrom $458Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Santiago de los Caballeros?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Charleston to Santiago de los Caballeros for you.

Can I find flights from Charleston to Santiago de los Caballeros with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago de los Caballeros from Charleston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Charleston to Santiago de los Caballeros?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago de los Caballeros from Charleston.

I’m not ready to book a flight from Charleston to Santiago de los Caballeros right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charleston to Santiago de los Caballeros now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago de los Caballeros and let you know when they change.

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