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Cheap flights from Charleston to Santiago de los Caballeros from $165

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Santiago de los Caballeros departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Charleston to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:05 am - 5:33 pmCHS  Charleston-STI Santiago de los Caballeros
11h 28m1 stop New York John F Kennedy Intl
Delta Logo
7:05 pm - 12:12 pmSTI  Santiago de los Caballeros-CHS Charleston
17h 07m1 stop New York John F Kennedy Intl
$364Delta
Wed, Oct 28 - Fri, Oct 30
Delta Logo
6:05 am - 5:33 pmCHS  Charleston-STI Santiago de los Caballeros
11h 28m1 stop New York John F Kennedy Intl
Delta Logo
7:05 pm - 12:12 pmSTI  Santiago de los Caballeros-CHS Charleston
17h 07m1 stop New York John F Kennedy Intl
$364Delta
Tue, Oct 27 - Fri, Oct 30
Delta Logo
5:30 am - 5:33 pmCHS  Charleston-STI Santiago de los Caballeros
12h 03m2 stops Atlanta Hartsfield-Jackson New York John F Kennedy Intl
Delta Logo
7:05 pm - 12:12 pmSTI  Santiago de los Caballeros-CHS Charleston
17h 07m1 stop New York John F Kennedy Intl
$369Delta
Wed, Oct 28 - Fri, Oct 30
Delta Logo
6:05 am - 5:33 pmCHS  Charleston-STI Santiago de los Caballeros
11h 28m1 stop New York John F Kennedy Intl
Delta Logo
7:05 pm - 1:18 pmSTI  Santiago de los Caballeros-CHS Charleston
18h 13m2 stops New York John F Kennedy Intl Atlanta Hartsfield-Jackson
$369Delta
Tue, Oct 27 - Fri, Oct 30
Delta Logo
6:30 am - 5:33 pmCHS  Charleston-STI Santiago de los Caballeros
11h 03m2 stops Atlanta Hartsfield-Jackson New York John F Kennedy Intl
Delta Logo
7:05 pm - 11:04 amSTI  Santiago de los Caballeros-CHS Charleston
15h 59m2 stops New York John F Kennedy Intl Atlanta Hartsfield-Jackson
$369Delta
Wed, Oct 28 - Fri, Oct 30
Delta Logo
7:10 am - 5:33 pmCHS  Charleston-STI Santiago de los Caballeros
10h 23m2 stops Detroit Metropolitan Wayne County New York John F Kennedy Intl
Delta Logo
7:05 pm - 1:18 pmSTI  Santiago de los Caballeros-CHS Charleston
18h 13m2 stops New York John F Kennedy Intl Atlanta Hartsfield-Jackson
$369Delta
Tue, Oct 27 - Fri, Oct 30
American Airlines Logo
6:00 am - 9:07 pmCHS  Charleston-STI Santiago de los Caballeros
15h 07m1 stop Miami
American Airlines Logo
7:00 am - 11:54 pmSTI  Santiago de los Caballeros-CHS Charleston
16h 54m2 stops Miami Philadelphia
$405American Airlines
Fri, Aug 28 - Fri, Sep 4
American Airlines Logo
7:33 am - 9:07 pmCHS  Charleston-STI Santiago de los Caballeros
13h 34m2 stops Philadelphia Miami
American Airlines Logo
7:00 am - 11:54 pmSTI  Santiago de los Caballeros-CHS Charleston
16h 54m2 stops Miami Philadelphia
$405American Airlines
Fri, Aug 28 - Fri, Sep 4
American Airlines Logo
6:00 am - 9:07 pmCHS  Charleston-STI Santiago de los Caballeros
15h 07m1 stop Miami
American Airlines Logo
7:00 am - 11:59 pmSTI  Santiago de los Caballeros-CHS Charleston
16h 59m1 stop Miami
$408American Airlines
Fri, Aug 28 - Fri, Sep 4
American Airlines Logo
7:41 pm - 2:15 pmCHS  Charleston-STI Santiago de los Caballeros
18h 34m2 stops Charlotte Douglas Miami
American Airlines Logo
3:15 pm - 9:47 amSTI  Santiago de los Caballeros-CHS Charleston
18h 32m2 stops Miami Charlotte Douglas
$410American Airlines
Wed, Sep 23 - Wed, Sep 30

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American Airlines flights from Charleston to Santiago de los Caballeros

Our best American Airlines deals on Charleston to Santiago de los Caballeros flight tickets
American Airlines
Aug 28
CHS6:00 amCharleston
15h 07m
1 stop
STI9:07 pmSantiago de los Caballeros
Sep 4
STI7:00 amSantiago de los Caballeros
16h 54m
2 stops
CHS11:54 pmCharleston
$405
American Airlines
Aug 28
CHS6:00 amCharleston
15h 07m
1 stop
STI9:07 pmSantiago de los Caballeros
Sep 4
STI7:00 amSantiago de los Caballeros
16h 59m
1 stop
CHS11:59 pmCharleston
$408
American Airlines
Sep 23
CHS7:41 pmCharleston
18h 34m
2 stops
STI2:15 pmSantiago de los Caballeros
Sep 30
STI3:15 pmSantiago de los Caballeros
18h 32m
2 stops
CHS9:47 amCharleston
$410

JetBlue flights from Charleston to Santiago de los Caballeros

Our best JetBlue deals on Charleston to Santiago de los Caballeros flight tickets
JetBlue
Jan 18
CHS1:35 pmCharleston
10h 16m
1 stop
STI12:51 amSantiago de los Caballeros
Jan 21
STI6:01 amSantiago de los Caballeros
7h 39m
1 stop
CHS12:40 pmCharleston
$504
JetBlue
Jan 18
CHS1:35 pmCharleston
10h 16m
1 stop
STI12:51 amSantiago de los Caballeros
Jan 21
STI6:01 amSantiago de los Caballeros
7h 39m
1 stop
CHS12:40 pmCharleston
$524
JetBlue
Sep 4
CHS8:25 pmCharleston
13h 26m
1 stop
STI9:51 amSantiago de los Caballeros
Sep 8
STI8:13 amSantiago de los Caballeros
8h 20m
1 stop
CHS4:33 pmCharleston
$561

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from Charleston to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonSantiago de los Caballeros

CHS Charleston - STI Santiago de los Caballeros

CHSSTI

Charleston

Wed 10/28

6:05 am-5:33 pm

1 stop11h 28m

Santiago de los Caballeros

Fri 10/30

7:05 pm-12:12 pm

1 stop17h 07m

$364

CharlestonSantiago de los Caballeros

CHS Charleston - STI Santiago de los Caballeros

CHSSTI

Charleston

Tue 10/27

6:05 am-5:33 pm

1 stop11h 28m

Santiago de los Caballeros

Fri 10/30

7:05 pm-12:12 pm

1 stop17h 07m

$364

CharlestonSantiago de los Caballeros

CHS Charleston - STI Santiago de los Caballeros

CHSSTI

Charleston

Wed 10/28

5:30 am-5:33 pm

2 stops12h 03m

Santiago de los Caballeros

Fri 10/30

7:05 pm-12:12 pm

1 stop17h 07m

$369

CharlestonSantiago de los Caballeros

CHS Charleston - STI Santiago de los Caballeros

CHSSTI

Charleston

Tue 10/27

6:05 am-5:33 pm

1 stop11h 28m

Santiago de los Caballeros

Fri 10/30

7:05 pm-1:18 pm

2 stops18h 13m

$369
Quickest round-trip

CharlestonSantiago de los Caballeros

CHS Charleston - STI Santiago de los Caballeros

CHSSTI

Charleston

Wed 10/28

6:30 am-5:33 pm

2 stops11h 03m

Santiago de los Caballeros

Fri 10/30

7:05 pm-11:04 am

2 stops15h 59m

$369

CharlestonSantiago de los Caballeros

CHS Charleston - STI Santiago de los Caballeros

CHSSTI

Charleston

Tue 10/27

7:10 am-5:33 pm

2 stops10h 23m

Santiago de los Caballeros

Fri 10/30

7:05 pm-1:18 pm

2 stops18h 13m

$369

CharlestonSantiago de los Caballeros

CHS Charleston - STI Santiago de los Caballeros

CHSSTI

Charleston

Fri 8/28

6:00 am-9:07 pm

1 stop15h 07m

Santiago de los Caballeros

Fri 9/4

7:00 am-11:54 pm

2 stops16h 54m

$405

CharlestonSantiago de los Caballeros

CHS Charleston - STI Santiago de los Caballeros

CHSSTI

Charleston

Fri 8/28

7:33 am-9:07 pm

2 stops13h 34m

Santiago de los Caballeros

Fri 9/4

7:00 am-11:54 pm

2 stops16h 54m

$405

CharlestonSantiago de los Caballeros

CHS Charleston - STI Santiago de los Caballeros

CHSSTI

Charleston

Fri 8/28

6:00 am-9:07 pm

1 stop15h 07m

Santiago de los Caballeros

Fri 9/4

7:00 am-11:59 pm

1 stop16h 59m

$408

CharlestonSantiago de los Caballeros

CHS Charleston - STI Santiago de los Caballeros

CHSSTI

Charleston

Wed 9/23

7:41 pm-2:15 pm

2 stops18h 34m

Santiago de los Caballeros

Wed 9/30

3:15 pm-9:47 am

2 stops18h 32m

$410

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from Charleston to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Charleston to Santiago de los Caballeros flights?

You could potentially save up to 19% on your flight if you consider stops on a Charleston to Santiago de los Caballeros flight.

When to book flights from Charleston to Santiago de los Caballeros

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Santiago de los Caballeros according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Santiago de los Caballeros (CHS to STI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Santiago de los Caballeros

Fastest flight time

10h 16m

Direct flights

None
The fastest flight from Charleston to Santiago de los Caballeros takes 10h 16m
There are no direct flights from Charleston to Santiago de los Caballeros. There are no popular flight routes from Charleston to Santiago de los Caballeros.
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Frequently asked questions about flying from Charleston to Santiago de los Caballeros

  • How far is Charleston to Santiago de los Caballeros by plane?

    Charleston and Santiago de los Caballeros are 1082.3 mi apart from one another. In terms of flight time, this usually takes a little over 10h 16m.

  • When did momondo last update prices for flights from Charleston Airport to Santiago de los Caballeros Airport?

    Prices for flights from Charleston Airport to Santiago de los Caballeros Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Charleston Airport to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from Charleston Airport to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charleston Airport to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The required travel and health documents for your Santiago de los Caballeros Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago de los Caballeros Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Charleston to Santiago de los Caballeros?

Best airlines flying from Charleston to Santiago de los Caballeros

Compare and see reviews for airlines that fly from Charleston to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $414Free CancellationRating
7.1
11,915 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Santiago de los Caballeros?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Charleston to Santiago de los Caballeros for you.

Can I find flights from Charleston to Santiago de los Caballeros with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago de los Caballeros from Charleston which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Charleston to Santiago de los Caballeros?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santiago de los Caballeros from Charleston.

I’m not ready to book a flight from Charleston to Santiago de los Caballeros right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charleston to Santiago de los Caballeros now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago de los Caballeros and let you know when they change.

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