Cheap flights from Cartagena to Panama City from $219

In general, April is the cheapest month to fly from Cartagena to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $204. If you’re not able to fly to Panama City in April, then June is your next best option. Flight prices from Cartagena to Panama City during June average around $224.

Our data shows that Friday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $310. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $422. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from Cartagena to Panama City during this time can be as low as $342. Try not to purchase tickets in the afternoon because they tend to be around $451. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Cartagena Rafael Nunez to Panama City Tocumen Intl for the best Cartagena Rafael Nunez - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Cartagena when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $268 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Cartagena for as low as $222 on momondo.

You could potentially save up to 16% on your flight if you consider stops on a Cartagena to Panama City flight.

As of May 2026, prices for Cartagena to Panama City flights are approximately 4% more expensive when compared to flights at the same time last year.

Copa Airlines and Avianca are the most popular carriers operating from Cartagena Rafael Nunez to Panama City Tocumen Intl

Copa Airlines, Wingo and Avianca are the top three most popular airlines that fly to Panama City from Cartagena according to our data. Copa Airlines is the first choice among our users, with 67% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 3 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

Historically, on average around 2% of flights between Cartagena and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 91 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights in the evening have, in the past, seen delays more frequently in comparison.

Saturday is statistically the day of the week which experiences the fewest number of delays on this flight route. Friday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 2% of their flights experiencing any sort of delay.

8 flights are operational daily from Cartagena to Panama City as of May 2026. The most popular departure time for this route is 3:00PM, with 60% of flights per day taking off in the afternoon.

As of May 2026, there are 62 flights per week flying from Cartagena to Panama City. The most common day of the week flights depart is Fri, with 16% of flights taking off on this day.