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Cheap flights from Buffalo to Santo Domingo from $146

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Santo Domingo departing on 3/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Buffalo to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:25 pm - 10:00 am
BUF
-
SDQ
16h 35m
2 stops
American Airlines Logo
6:00 am - 11:31 pm
SDQ
-
BUF
17h 31m
2 stops
$319American Airlines
Tue, Mar 3 - Wed, Mar 18
Delta Logo
3:39 pm - 12:32 am
BUF
-
SDQ
7h 53m
1 stop
Delta Logo
8:25 pm - 10:57 am
SDQ
-
BUF
14h 32m
1 stop
$329Delta
Tue, Mar 3 - Wed, Mar 18
JetBlue Logo
7:30 pm - 3:55 am
BUF
-
SDQ
7h 25m
1 stop
JetBlue Logo
8:56 pm - 9:02 am
SDQ
-
BUF
12h 06m
1 stop
$371JetBlue
Sat, Mar 7 - Sat, Mar 14
JetBlue Logo
7:58 pm - 12:30 am
BUF
-
SDQ
28h 32m
1 stop
JetBlue Logo
9:45 am - 11:09 pm
SDQ
-
BUF
13h 24m
1 stop
$409JetBlue
Fri, Mar 20 - Fri, Mar 27
JetBlue Logo
8:00 am - 5:14 pm
BUF
-
SDQ
8h 14m
1 stop
JetBlue Logo
10:35 pm - 9:40 am
SDQ
-
BUF
12h 05m
1 stop
$422JetBlue
Thu, Feb 26 - Sun, Mar 1
JetBlue Logo
6:00 am - 3:11 pm
BUF
-
SDQ
8h 11m
1 stop
JetBlue Logo
6:05 am - 1:04 pm
SDQ
-
BUF
7h 59m
1 stop
$443JetBlue
Thu, Feb 26 - Sun, Mar 1
JetBlue Logo
8:00 am - 5:14 pm
BUF
-
SDQ
8h 14m
1 stop
JetBlue Logo
10:35 pm - 9:40 am
SDQ
-
BUF
12h 05m
1 stop
$446JetBlue
Thu, Feb 26 - Sun, Mar 1
JetBlue Logo
7:20 am - 8:18 pm
BUF
-
SDQ
12h 58m
1 stop
JetBlue Logo
1:40 am - 11:30 am
SDQ
-
BUF
9h 50m
1 stop
$471JetBlue
Wed, Jul 8 - Tue, Jul 21
JetBlue Logo
6:00 am - 3:11 pm
BUF
-
SDQ
8h 11m
1 stop
JetBlue Logo
6:20 am - 6:38 pm
SDQ
-
BUF
13h 18m
1 stop
$483JetBlue
Thu, Feb 26 - Sun, Mar 1
Multiple Airlines Logo
9:25 pm - 9:41 am
BUF
-
SDQ
12h 16m
1 stop
Multiple Airlines Logo
2:52 am - 10:49 am
SDQ
-
BUF
31h 57m
2 stops
$499Multiple Airlines
Fri, Mar 20 - Thu, Mar 26

American Airlines flights from Buffalo to Santo Domingo

Our best American Airlines deals on Buffalo to Santo Domingo flight tickets
American Airlines
Mar 3
BUF4:25 pmBuffalo
16h 35m
2 stops
SDQ10:00 amSanto Domingo Las Americas
Mar 18
SDQ6:00 amSanto Domingo Las Americas
17h 31m
2 stops
BUF11:31 pmBuffalo
$319
American Airlines
Jul 8
BUF10:48 amBuffalo
12h 11m
2 stops
SDQ10:59 pmSanto Domingo Las Americas
Jul 22
SDQ2:19 pmSanto Domingo Las Americas
10h 33m
2 stops
BUF12:52 amBuffalo
$549
American Airlines
Jul 8
BUF6:05 amBuffalo
15h 53m
1 stop
SDQ9:58 pmSanto Domingo Las Americas
Jul 22
SDQ2:19 pmSanto Domingo Las Americas
10h 33m
2 stops
BUF12:52 amBuffalo
$580

JetBlue flights from Buffalo to Santo Domingo

Our best JetBlue deals on Buffalo to Santo Domingo flight tickets
JetBlue
Mar 7
BUF7:30 pmBuffalo
7h 25m
1 stop
SDQ3:55 amSanto Domingo Las Americas
Mar 14
SDQ8:56 pmSanto Domingo Las Americas
12h 06m
1 stop
BUF9:02 amBuffalo
$371
JetBlue
Mar 20
BUF7:58 pmBuffalo
28h 32m
1 stop
SDQ12:30 amSanto Domingo Las Americas
Mar 27
SDQ9:45 amSanto Domingo Las Americas
13h 24m
1 stop
BUF11:09 pmBuffalo
$409
JetBlue
Feb 26
BUF8:00 amBuffalo
8h 14m
1 stop
SDQ5:14 pmSanto Domingo Las Americas
Mar 1
SDQ10:35 pmSanto Domingo Las Americas
12h 05m
1 stop
BUF9:40 amBuffalo
$422

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 6, 2026.
Use the filters below to find and compare flights from Buffalo to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloSanto Domingo

BUF - SDQ

BUFSDQ

Buffalo

Tue 3/3

4:25 pm-10:00 am

2 stops16h 35m

Santo Domingo Las Americas

Wed 3/18

6:00 am-11:31 pm

2 stops17h 31m

$319

BuffaloSanto Domingo

BUF - SDQ

BUFSDQ

Buffalo

Tue 3/3

3:39 pm-12:32 am

1 stop7h 53m

Santo Domingo Las Americas

Wed 3/18

8:25 pm-10:57 am

1 stop14h 32m

$329

BuffaloSanto Domingo

BUF - SDQ

BUFSDQ

Buffalo

Sat 3/7

7:30 pm-3:55 am

1 stop7h 25m

Santo Domingo Las Americas

Sat 3/14

8:56 pm-9:02 am

1 stop12h 06m

$371

BuffaloSanto Domingo

BUF - SDQ

BUFSDQ

Buffalo

Fri 3/20

7:58 pm-12:30 am

1 stop28h 32m

Santo Domingo Las Americas

Fri 3/27

9:45 am-11:09 pm

1 stop13h 24m

$409

BuffaloSanto Domingo

BUF - SDQ

BUFSDQ

Buffalo

Thu 2/26

8:00 am-5:14 pm

1 stop8h 14m

Santo Domingo Las Americas

Sun 3/1

10:35 pm-9:40 am

1 stop12h 05m

$422

BuffaloSanto Domingo

BUF - SDQ

BUFSDQ

Buffalo

Thu 2/26

6:00 am-3:11 pm

1 stop8h 11m

Santo Domingo Las Americas

Sun 3/1

6:05 am-1:04 pm

1 stop7h 59m

$443

BuffaloSanto Domingo

BUF - SDQ

BUFSDQ

Buffalo

Thu 2/26

8:00 am-5:14 pm

1 stop8h 14m

Santo Domingo Las Americas

Sun 3/1

10:35 pm-9:40 am

1 stop12h 05m

$446

BuffaloSanto Domingo

BUF - SDQ

BUFSDQ

Buffalo

Wed 7/8

7:20 am-8:18 pm

1 stop12h 58m

Santo Domingo Las Americas

Tue 7/21

1:40 am-11:30 am

1 stop9h 50m

$471

BuffaloSanto Domingo

BUF - SDQ

BUFSDQ

Buffalo

Thu 2/26

6:00 am-3:11 pm

1 stop8h 11m

Santo Domingo Las Americas

Sun 3/1

6:20 am-6:38 pm

1 stop13h 18m

$483

BuffaloSanto Domingo

BUF - SDQ

BUFSDQ

Buffalo

Fri 3/20

9:25 pm-9:41 am

1 stop12h 16m

Santo Domingo Las Americas

Thu 3/26

2:52 am-10:49 am

2 stops31h 57m

$499

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Buffalo to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in March, then you should wait until June to fly from Buffalo, when ticket prices are also cheap, with an average price of $432.

Can stopping save me money on Buffalo to Santo Domingo flights?

You could potentially save up to 21% on your flight if you consider stops on a Buffalo to Santo Domingo flight.

When to book flights from Buffalo to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Santo Domingo (BUF to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Santo Domingo

Fastest flight time

6h 25m

Direct flights

None
The fastest flight from Buffalo to Santo Domingo takes 6h 25m
There are no direct flights from Buffalo to Santo Domingo. There are no popular flight routes from Buffalo to Santo Domingo.
Search flight deals

  • How far is Buffalo to Santo Domingo Las Americas by plane?

    Santo Domingo Las Americas is 1764.1 mi away from Buffalo. By plane, this route typically takes 6h 25m.

  • When did momondo last update prices for flights from Buffalo Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Buffalo Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Buffalo Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Buffalo Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Buffalo to Santo Domingo?

Best airlines flying from Buffalo to Santo Domingo

Compare and see reviews for airlines that fly from Buffalo to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $325Free CancellationRating
7.2
2,898 reviews
Search JetBlue flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Santo Domingo?

Finding the right flight to Santo Domingo from Buffalo is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santo Domingo quick and easy, saving you time and money.

Can I find flights from Buffalo to Santo Domingo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santo Domingo from Buffalo with this policy.

How can momondo help me find flights from Buffalo to Santo Domingo?

momondo provides multiple filters to help you find the best flight to Santo Domingo from Buffalo. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Buffalo to Santo Domingo right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Buffalo to Santo Domingo flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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