Experience the charm of St. Louis at the Holiday Inn St. Louis SW – Route 66, where friendly service, comfortable accommodations and thoughtful amenities make every stay a delight. Conveniently located in Sunset Hills along historic Route 66 at I-44 and I-270, our full-service hotel is an ideal choice for business travelers, families and groups. Explore St. Louis favorites like the Gateway Arch, St. Louis Zoo, Missouri Botanical Garden, Busch Stadium, The Magic House & Six Flags St. Louis. Our location provides access to major business destinations & medical centers throughout Fenton, Sunset Hills and the greater St. Louis area. Traveling for business? Enjoy complimentary parking & Wi-Fi, a state-of-the-art fitness center, spacious guest rooms & flexible meeting rooms for business meetings, training sessions and team gatherings. Whether you're visiting corporate offices, working on a local project or visiting nearby medical facilities, ask our sales team about corporate lodging options and negotiated rates. Enjoy an exceptional meal at the award-winning Twisted Tree Steakhouse, breakfast at Wakey Wakey Breakfast Place, or cocktails and appetizers at Luxe Libations: The Lounge by Twisted Tree. Unwind at our heated outdoor pool with cabanas, gather around the fire pits or enjoy yard games in our outdoor courtyard. Whether you're visiting for business, leisure or a special occasion, Holiday Inn St. Louis SW – Route 66 offers the location & amenities you deserve.