Experience the charm of St. Louis at the renovated Holiday Inn St Louis SW - Route 66, a hotel blending utmost comfort with a prime location and exceptional service to provide an unforgettable stay. Located on historic Route 66 at highway I-44 and I-270, just 20 minutes from St. Louis Lambert International Airport, we offer easy access to top St. Louis attractions like The Gateway Arch, Missouri Botanical Garden, and the St. Louis Zoo. Catch a St. Louis Cardinals game at Busch Stadium, visit the Magic House, St. Louis Science Center, Six Flags or World Wide Technology Soccer Park. Business travelers appreciate proximity to companies like Maritz, Harris-Stowe, and top medical centers like Barnes Jewish Hospital, St. Louis Children's Hospital, SSM Health, and Mercy Hospital. Enjoy top amenities like a resort-style outdoor pool with luxury cabanas and a state-of-the-art Fitness Center. Relax by our fire pit with a cocktail or play yard games with family or friends. Savor delicious dining at our award-winning steakhouse, Twisted Tree Steakhouse, plus breakfast at Wakey Wakey Breakfast Place, and cocktails at Luxe Libations: The Lounge by Twisted Tree. From our elegant Sunset Event Center venues to complimentary parking, free Wi-Fi, and spacious rooms and suites, we are the ideal choice for an exciting and enjoyable stay in St. Louis.