Settle in for a relaxing stay at the Sikeston’s newest hotel. Our Hampton Inn Sikeston hotel is located off Highway 60 and Interstate 55, just minutes from historic downtown and within walking distance to many shops and restaurants. Settle in for a relaxing stay in one of our modern guest rooms. Enjoy the convenience of a mini-refrigerator, microwave, free WiFi, coffeemaker, 42-inch flat-screen TV with premium cable channels and work desk with ergonomic chair. Upgrade to a studio suite for extra space and a separate seating area. Start each day with our free hot breakfast or, if you’re in a hurry, grab one of Hampton’s On the Run™ Breakfast Bags, available Monday through Friday. Stop by our Treats Shop any time of day or night for a quick snack or beverage. Stay in shape with a workout in our 24-hour fitness center or take a dip in our indoor heated pool. Plan a meeting in our 700 sq. ft. of meeting space fully equipped with A/V equipment.