> The Holiday Inn Express Hotel & Suites in O'Fallon, MO is located just west of St. Louis. Our hotel is convenient to Interstate 64 and is near several local attractions and businesses making it the perfect hotel for travelers looking for lodging in O'Fallon. Our O’Fallon hotel is conveniently located near major businesses including Citi, General Motors, Mastercard, APC, Nortek, the Missouri Research Park, and Progress West Hospital, making us an ideal choice for business travelers. When it’s time to relax, you’ll find plenty of fun nearby. We’re just minutes from historic St. Charles, Six Flags St. Louis, and the O’Fallon Sports Complex. And with downtown St. Louis only a short drive away, you can easily explore iconic attractions like the Gateway Arch, Anheuser-Busch Brewery, Laclede’s Landing, and cheer on the Cardinals or the Blues at their home stadiums. Whether you’re here for meetings or memories, our location puts the best of St. Louis within easy reach. Bring the whole family—even the four-legged ones! Our pet-friendly O’Fallon hotel features a heated indoor pool, modern fitness center, and our free Express Start breakfast bar with favorites like fresh coffee and signature cinnamon rolls. Explore our latest deals and book your stay today.