Cheap flights from the United States to Panama City from $221

In general, October is the cheapest month to fly from United States to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $584. If you’re not able to fly to Panama City in October, then May is your next best option. Flight prices from United States to Panama City during May average around $593.

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $630. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $657. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from United States to Panama City during this time can be as low as $582. Try not to purchase tickets in the morning because they tend to be around $693. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Orlando to Panama City Tocumen Intl for the best United States - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from United States when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $650 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from United States for as low as $562 on momondo.

There are 3 cabin classes available to choose from on United States to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines, Copa Airlines, and Avianca are the most popular carriers operating from United States to Panama City Tocumen Intl

Copa Airlines, United Airlines and Avianca are the top three most popular airlines that fly to Panama City from United States according to our data. Copa Airlines is the first choice among our users, with 69% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 7 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

Historically, on average around 12% of flights between United States and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 128 minutes.

Generally, flights departing in the evening tend to experience fewer delays. Flights in the morning have, in the past, seen delays more frequently in comparison.

Friday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 8% of their flights experiencing any sort of delay.

As of August 2026, there are 42 flights per day flying from United States to Panama City. The most common time of day flights depart is 1:00AM, with 31% of flights taking off at noon.

As of August 2026, 297 flights take off from United States and land in Panama City each week. The most common flight departure day for this route is Sat, with 16% of weekly flights taking off on this day.