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Cheap flights from St. Louis to Santa Cruz de la Sierra from $432

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Santa Cruz de la Sierra departing on 12/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Santa Cruz de la Sierra

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:00 am - 10:38 pmSTL  Lambert-St Louis-VVI Santa Cruz de la Sierra Viru Viru Intl
38h 38m2 stops Newark Panama City Tocumen Intl
Multiple Airlines Logo
3:40 am - 6:38 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-STL Lambert-St Louis
16h 58m2 stops Bogotá El Dorado Houston George Bush Intcntl
$926Multiple Airlines
Thu, Nov 19 - Wed, Nov 25
Multiple Airlines Logo
7:33 am - 10:46 pmSTL  Lambert-St Louis-VVI Santa Cruz de la Sierra Viru Viru Intl
37h 13m2 stops Chicago O'Hare Intl Panama City Tocumen Intl
Multiple Airlines Logo
3:40 am - 10:06 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-STL Lambert-St Louis
20h 26m2 stops Bogotá El Dorado Houston George Bush Intcntl
$1,168Multiple Airlines
Thu, Jan 14 - Sat, Jan 30
Copa Airlines Logo
8:05 am - 3:44 amSTL  Lambert-St Louis-VVI Santa Cruz de la Sierra Viru Viru Intl
17h 39m2 stops Chicago O'Hare Intl Panama City Tocumen Intl
Copa Airlines Logo
1:14 am - 11:09 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-STL Lambert-St Louis
23h 55m2 stops Panama City Tocumen Intl Chicago O'Hare Intl
$1,422Copa Airlines
Fri, Jan 1 - Tue, Jan 12
Multiple Airlines Logo
1:08 pm - 10:46 pmSTL  Lambert-St Louis-VVI Santa Cruz de la Sierra Viru Viru Intl
55h 38m3 stops Chicago O'Hare Intl Houston George Bush Intcntl Panama City Tocumen Intl
Multiple Airlines Logo
3:40 am - 10:06 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-STL Lambert-St Louis
20h 26m2 stops Bogotá El Dorado Houston George Bush Intcntl
$1,685Multiple Airlines
Thu, Jan 14 - Sat, Jan 30
Multiple Airlines Logo
6:04 am - 10:48 pmSTL  Lambert-St Louis-VVI Santa Cruz de la Sierra Viru Viru Intl
38h 44m2 stops Newark Panama City Tocumen Intl
Multiple Airlines Logo
3:40 am - 10:19 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-STL Lambert-St Louis
44h 39m2 stops Bogotá El Dorado Houston George Bush Intcntl
$2,665Multiple Airlines
Sat, Dec 19 - Fri, Dec 25
Multiple Airlines Logo
4:05 pm - 8:25 pmSTL  Lambert-St Louis-VVI Santa Cruz de la Sierra Viru Viru Intl
26h 20m2 stops Toronto Pearson Intl Sao Paulo Guarulhos Intl
Multiple Airlines Logo
6:50 am - 3:26 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-STL Lambert-St Louis
34h 36m3 stops La Paz El Alto Intl Bogotá El Dorado Toronto Pearson Intl
$2,936Multiple Airlines
Fri, Jan 1 - Wed, Jan 13
Multiple Airlines Logo
4:05 pm - 8:30 pmSTL  Lambert-St Louis-VVI Santa Cruz de la Sierra Viru Viru Intl
26h 25m3 stops Toronto Pearson Intl Sao Paulo Guarulhos Intl Cochabamba J Wilsterman
Multiple Airlines Logo
6:50 am - 3:26 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-STL Lambert-St Louis
34h 36m3 stops La Paz El Alto Intl Bogotá El Dorado Toronto Pearson Intl
$2,993Multiple Airlines
Fri, Jan 1 - Wed, Jan 13
Multiple Airlines Logo
4:05 pm - 1:10 amSTL  Lambert-St Louis-VVI Santa Cruz de la Sierra Viru Viru Intl
31h 05m3 stops Toronto Pearson Intl Sao Paulo Guarulhos Intl Buenos Aires Ministro Pistarini
Multiple Airlines Logo
1:40 pm - 3:26 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-STL Lambert-St Louis
27h 46m2 stops Sao Paulo Guarulhos Intl Toronto Pearson Intl
$3,400Multiple Airlines
Thu, Nov 19 - Thu, Nov 26

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Customize your flight search to find flights from St. Louis to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 8, 2026.
Use the filters below to find and compare flights from St. Louis to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSanta Cruz de la Sierra

STL Lambert-St Louis - VVI Santa Cruz de la Sierra Viru Viru Intl

STLVVI

Lambert-St Louis

Thu 11/19

6:00 am-10:38 pm

2 stops38h 38m

Santa Cruz de la Sierra Viru Viru Intl

Wed 11/25

3:40 am-6:38 pm

2 stops16h 58m

$926

St. LouisSanta Cruz de la Sierra

STL Lambert-St Louis - VVI Santa Cruz de la Sierra Viru Viru Intl

STLVVI

Lambert-St Louis

Thu 1/14

7:33 am-10:46 pm

2 stops37h 13m

Santa Cruz de la Sierra Viru Viru Intl

Sat 1/30

3:40 am-10:06 pm

2 stops20h 26m

$1,168
Quickest round-trip

St. LouisSanta Cruz de la Sierra

STL Lambert-St Louis - VVI Santa Cruz de la Sierra Viru Viru Intl

STLVVI

Lambert-St Louis

Fri 1/1

8:05 am-3:44 am

2 stops17h 39m

Santa Cruz de la Sierra Viru Viru Intl

Tue 1/12

1:14 am-11:09 pm

2 stops23h 55m

$1,422

St. LouisSanta Cruz de la Sierra

STL Lambert-St Louis - VVI Santa Cruz de la Sierra Viru Viru Intl

STLVVI

Lambert-St Louis

Thu 1/14

1:08 pm-10:46 pm

3 stops55h 38m

Santa Cruz de la Sierra Viru Viru Intl

Sat 1/30

3:40 am-10:06 pm

2 stops20h 26m

$1,685

St. LouisSanta Cruz de la Sierra

STL Lambert-St Louis - VVI Santa Cruz de la Sierra Viru Viru Intl

STLVVI

Lambert-St Louis

Sat 12/19

6:04 am-10:48 pm

2 stops38h 44m

Santa Cruz de la Sierra Viru Viru Intl

Fri 12/25

3:40 am-10:19 pm

2 stops44h 39m

$2,665

St. LouisSanta Cruz de la Sierra

STL Lambert-St Louis - VVI Santa Cruz de la Sierra Viru Viru Intl

STLVVI

Lambert-St Louis

Fri 1/1

4:05 pm-8:25 pm

2 stops26h 20m

Santa Cruz de la Sierra Viru Viru Intl

Wed 1/13

6:50 am-3:26 pm

3 stops34h 36m

$2,936

St. LouisSanta Cruz de la Sierra

STL Lambert-St Louis - VVI Santa Cruz de la Sierra Viru Viru Intl

STLVVI

Lambert-St Louis

Fri 1/1

4:05 pm-8:30 pm

3 stops26h 25m

Santa Cruz de la Sierra Viru Viru Intl

Wed 1/13

6:50 am-3:26 pm

3 stops34h 36m

$2,993

St. LouisSanta Cruz de la Sierra

STL Lambert-St Louis - VVI Santa Cruz de la Sierra Viru Viru Intl

STLVVI

Lambert-St Louis

Thu 11/19

4:05 pm-1:10 am

3 stops31h 05m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/26

1:40 pm-3:26 pm

2 stops27h 46m

$3,400
Cheapest one-way
Quickest one-way

St. LouisSanta Cruz de la Sierra

STL Lambert-St Louis - VVI Santa Cruz de la Sierra Viru Viru Intl

STLVVI

Lambert-St Louis

Tue 12/1

7:33 am-3:42 am

2 stops18h 09m

$432

St. LouisSanta Cruz de la Sierra

STL Lambert-St Louis - VVI Santa Cruz de la Sierra Viru Viru Intl

STLVVI

Lambert-St Louis

Tue 12/1

6:05 pm-8:25 pm

3 stops48h 20m

$634

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santa Cruz de la Sierra from

How to get the cheapest flight ticket from St. Louis to Santa Cruz de la Sierra

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Lambert-St Louis to Santa Cruz de la Sierra Viru Viru Intl?

United Airlines is the most popular carrier operating from Lambert-St Louis to Santa Cruz de la Sierra Viru Viru Intl

When to book flights from St. Louis to Santa Cruz de la Sierra

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Santa Cruz de la Sierra according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Santa Cruz de la Sierra (STL to VVI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Santa Cruz de la Sierra

Fastest flight time

17h 09m

Direct flights

None
The fastest flight from St. Louis to Santa Cruz de la Sierra takes 17h 09m
There are no direct flights from St. Louis to Santa Cruz de la Sierra. There are no popular flight routes from St. Louis to Santa Cruz de la Sierra.
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Frequently asked questions about flying from St. Louis to Santa Cruz de la Sierra

  • How far is Lambert-St Louis to Santa Cruz de la Sierra Viru Viru Intl by plane?

    A flight from Lambert-St Louis to Santa Cruz de la Sierra Viru Viru Intl will travel around 4271.6 mi. 17h 09m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Santa Cruz de la Sierra Viru Viru Intl Airport?

    Prices for flights from Lambert-St Louis Airport to Santa Cruz de la Sierra Viru Viru Intl Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Santa Cruz de la Sierra Viru Viru Intl Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Santa Cruz de la Sierra Viru Viru Intl Airport.

  • What documentation or ID do you need to fly to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The required travel and health documents for your Santa Cruz de la Sierra Viru Viru Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Cruz de la Sierra Viru Viru Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Santa Cruz de la Sierra?

Best airlines flying from St. Louis to Santa Cruz de la Sierra

Compare and see reviews for airlines that fly from St. Louis to Santa Cruz de la Sierra with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $770Free CancellationRating
7.6
1,563 reviews
Search Copa Airlines flights

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Why should I use momondo to find a flight deal from St. Louis to Santa Cruz de la Sierra?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to Santa Cruz de la Sierra for you.

Can I find flights from St. Louis to Santa Cruz de la Sierra with flexible booking policies on momondo?

All flight searches from St. Louis to Santa Cruz de la Sierra on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from St. Louis to Santa Cruz de la Sierra?

Once you have performed a search for St. Louis to Santa Cruz de la Sierra flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to Santa Cruz de la Sierra right now. Can momondo alert me if prices change?

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