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Cheap flights from St. Louis to Panama City from $255

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 7/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:15 am - 6:37 pm
STL
-
PTY
7h 22m
1 stop
United Airlines Logo
9:45 am - 11:38 pm
PTY
-
STL
13h 53m
1 stop
$575United Airlines
Mon, Sep 14 - Thu, Sep 17
United Airlines Logo
5:59 pm - 2:14 pm
STL
-
PTY
20h 15m
2 stops
United Airlines Logo
9:45 am - 11:44 pm
PTY
-
STL
13h 59m
1 stop
$579United Airlines
Sun, Aug 2 - Mon, Aug 10
United Airlines Logo
2:57 pm - 4:12 pm
STL
-
PTY
25h 15m
1 stop
United Airlines Logo
9:45 am - 11:44 pm
PTY
-
STL
13h 59m
1 stop
$585United Airlines
Sun, Aug 2 - Mon, Aug 10
United Airlines Logo
8:00 am - 6:37 pm
STL
-
PTY
10h 37m
2 stops
United Airlines Logo
3:30 pm - 3:38 pm
PTY
-
STL
24h 08m
2 stops
$589United Airlines
Mon, Sep 14 - Thu, Sep 17
United Airlines Logo
11:10 am - 6:37 pm
STL
-
PTY
7h 27m
1 stop
United Airlines Logo
9:45 am - 11:36 pm
PTY
-
STL
13h 51m
1 stop
$592United Airlines
Fri, Jul 31 - Tue, Aug 4
United Airlines Logo
6:14 am - 6:37 pm
STL
-
PTY
12h 23m
1 stop
United Airlines Logo
7:55 am - 11:29 pm
PTY
-
STL
15h 34m
2 stops
$596United Airlines
Fri, Jul 31 - Tue, Aug 4
United Airlines Logo
6:30 pm - 6:37 pm
STL
-
PTY
24h 07m
1 stop
United Airlines Logo
3:30 pm - 12:02 pm
PTY
-
STL
20h 32m
2 stops
$599United Airlines
Sun, Aug 2 - Mon, Aug 10
United Airlines Logo
6:14 am - 4:12 pm
STL
-
PTY
9h 58m
1 stop
United Airlines Logo
7:55 am - 8:40 pm
PTY
-
STL
12h 45m
1 stop
$602United Airlines
Fri, Jul 31 - Tue, Aug 4
United Airlines Logo
6:30 pm - 6:37 pm
STL
-
PTY
24h 07m
1 stop
United Airlines Logo
3:30 pm - 6:04 pm
PTY
-
STL
26h 34m
1 stop
$605United Airlines
Sun, Aug 2 - Mon, Aug 10
United Airlines Logo
6:14 am - 4:12 pm
STL
-
PTY
9h 58m
1 stop
United Airlines Logo
3:30 pm - 2:23 pm
PTY
-
STL
22h 53m
2 stops
$606United Airlines
Fri, Jul 31 - Tue, Aug 4

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American Airlines flights from St. Louis to Panama City

Our best American Airlines deals on St. Louis to Panama City flight tickets
American Airlines
Jul 13
STL1:16 pmLambert-St Louis
22h 58m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Jul 19
PTY1:14 pmPanama City Tocumen Intl
21h 21m
2 stops
STL10:35 amLambert-St Louis
$614
American Airlines
Dec 6
STL6:53 pmLambert-St Louis
17h 55m
2 stops
PTY1:48 pmPanama City Tocumen Intl
Dec 13
PTY2:50 pmPanama City Tocumen Intl
19h 33m
2 stops
STL9:23 amLambert-St Louis
$618
American Airlines
Jul 14
STL6:13 pmLambert-St Louis
18h 01m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Aug 18
PTY1:39 pmPanama City Tocumen Intl
23h 15m
2 stops
STL12:54 pmLambert-St Louis
$632

United Airlines flights from St. Louis to Panama City

Our best United Airlines deals on St. Louis to Panama City flight tickets
United Airlines
Sep 14
STL11:15 amLambert-St Louis
7h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Sep 17
PTY9:45 amPanama City Tocumen Intl
13h 53m
1 stop
STL11:38 pmLambert-St Louis
$575
United Airlines
Aug 2
STL5:59 pmLambert-St Louis
20h 15m
2 stops
PTY2:14 pmPanama City Tocumen Intl
Aug 10
PTY9:45 amPanama City Tocumen Intl
13h 59m
1 stop
STL11:44 pmLambert-St Louis
$579
United Airlines
Aug 2
STL2:57 pmLambert-St Louis
25h 15m
1 stop
PTY4:12 pmPanama City Tocumen Intl
Aug 10
PTY9:45 amPanama City Tocumen Intl
13h 59m
1 stop
STL11:44 pmLambert-St Louis
$585

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 18, 2026.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 9/14

11:15 am-6:37 pm

1 stop7h 22m

Panama City Tocumen Intl

Thu 9/17

9:45 am-11:38 pm

1 stop13h 53m

$575

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 8/2

5:59 pm-2:14 pm

2 stops20h 15m

Panama City Tocumen Intl

Mon 8/10

9:45 am-11:44 pm

1 stop13h 59m

$579

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 8/2

2:57 pm-4:12 pm

1 stop25h 15m

Panama City Tocumen Intl

Mon 8/10

9:45 am-11:44 pm

1 stop13h 59m

$585

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 9/14

8:00 am-6:37 pm

2 stops10h 37m

Panama City Tocumen Intl

Thu 9/17

3:30 pm-3:38 pm

2 stops24h 08m

$589

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 7/31

11:10 am-6:37 pm

1 stop7h 27m

Panama City Tocumen Intl

Tue 8/4

9:45 am-11:36 pm

1 stop13h 51m

$592

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 7/31

6:14 am-6:37 pm

1 stop12h 23m

Panama City Tocumen Intl

Tue 8/4

7:55 am-11:29 pm

2 stops15h 34m

$596

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 8/2

6:30 pm-6:37 pm

1 stop24h 07m

Panama City Tocumen Intl

Mon 8/10

3:30 pm-12:02 pm

2 stops20h 32m

$599

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 7/31

6:14 am-4:12 pm

1 stop9h 58m

Panama City Tocumen Intl

Tue 8/4

7:55 am-8:40 pm

1 stop12h 45m

$602

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 8/2

6:30 pm-6:37 pm

1 stop24h 07m

Panama City Tocumen Intl

Mon 8/10

3:30 pm-6:04 pm

1 stop26h 34m

$605

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 7/31

6:14 am-4:12 pm

1 stop9h 58m

Panama City Tocumen Intl

Tue 8/4

3:30 pm-2:23 pm

2 stops22h 53m

$606

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from St. Louis to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Panama City?

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from St. Louis to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $495. If you’re not able to fly to Panama City in April, then November is your next best option. Flight prices from St. Louis to Panama City during November average around $510.

Can stopping save me money on St. Louis to Panama City flights?

You could potentially save up to 15% on your flight if you consider stops on a St. Louis to Panama City flight.

When to book flights from St. Louis to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City (STL to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City

Fastest flight time

7h 22m

Direct flights

None
The fastest flight from St. Louis to Panama City takes 7h 22m
There are no direct flights from St. Louis to Panama City. There are no popular flight routes from St. Louis to Panama City.
Search flight deals

Frequently asked questions about flying from St. Louis to Panama City

  • How far is Lambert-St Louis to Panama City Tocumen Intl by plane?

    There are 2151.1 mi between Lambert-St Louis and Panama City Tocumen Intl. Flights usually cover this in 7h 22m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Panama City?

Best airlines flying from St. Louis to Panama City

Compare and see reviews for airlines that fly from St. Louis to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $393Free CancellationRating
7.4
9,859 reviews
Search United Airlines flights
American AirlinesPriceFrom $393Free CancellationRating
7.1
11,686 reviews
Search American Airlines flights
DeltaPriceFrom $452Free CancellationRating
7.8
8,410 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from St. Louis are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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