Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from St. Louis to Panama City from $252

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 9/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

Delta Logo
6:00 am - 12:56 pmSTL-PTY
6h 56m1 stop
Delta Logo
2:21 pm - 11:41 pmPTY-STL
9h 20m1 stop
$386Delta
Find Deal
Mon, Oct 13 - Thu, Oct 23
United Airlines Logo
6:15 am - 2:14 pmSTL-PTY
7h 59m1 stop
United Airlines Logo
10:00 am - 6:57 pmPTY-STL
8h 57m1 stop
$393United Airlines
Find Deal
Tue, Oct 14 - Wed, Oct 22
United Airlines Logo
6:15 am - 6:37 pmSTL-PTY
12h 22m1 stop
United Airlines Logo
3:30 pm - 10:49 amPTY-STL
19h 19m2 stops
$398United Airlines
Find Deal
Mon, Oct 13 - Mon, Oct 20
American Airlines Logo
3:03 pm - 2:03 pmSTL-PTY
23h 00m2 stops
American Airlines Logo
3:15 pm - 9:35 amPTY-STL
18h 20m2 stops
$399American Airlines
Find Deal
Tue, Oct 14 - Thu, Oct 23
United Airlines Logo
6:15 am - 6:37 pmSTL-PTY
12h 22m1 stop
United Airlines Logo
3:41 pm - 6:47 pmPTY-STL
27h 06m1 stop
$401United Airlines
Find Deal
Thu, Oct 23 - Mon, Oct 27
Delta Logo
6:00 am - 12:56 pmSTL-PTY
6h 56m1 stop
Delta Logo
2:21 pm - 11:41 pmPTY-STL
9h 20m1 stop
$403Delta
Find Deal
Mon, Oct 13 - Fri, Oct 24
United Airlines Logo
6:15 am - 2:14 pmSTL-PTY
7h 59m1 stop
United Airlines Logo
10:00 am - 10:00 pmPTY-STL
12h 00m1 stop
$410United Airlines
Find Deal
Fri, Oct 17 - Tue, Oct 21
United Airlines Logo
6:15 am - 2:14 pmSTL-PTY
7h 59m1 stop
United Airlines Logo
3:30 pm - 10:49 amPTY-STL
19h 19m2 stops
$415United Airlines
Find Deal
Fri, Oct 17 - Thu, Oct 23
American Airlines Logo
6:08 pm - 2:03 pmSTL-PTY
19h 55m1 stop
American Airlines Logo
3:15 pm - 9:28 amPTY-STL
18h 13m2 stops
$473American Airlines
Find Deal
Thu, Oct 23 - Mon, Oct 27
American Airlines Logo
3:03 pm - 2:03 pmSTL-PTY
23h 00m2 stops
American Airlines Logo
3:15 pm - 12:05 pmPTY-STL
20h 50m2 stops
$480American Airlines
Find Deal
Wed, Oct 15 - Thu, Oct 23

Delta flights from St. Louis to Panama City

Our best Delta deals on St. Louis to Panama City flight tickets
Delta
Oct 13
STL6:00 amLambert-St Louis
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
Oct 23
PTY2:21 pmPanama City Tocumen Intl
9h 20m
1 stop
STL11:41 pmLambert-St Louis
$386
Find similar
Delta
Oct 13
STL6:00 amLambert-St Louis
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
Oct 24
PTY2:21 pmPanama City Tocumen Intl
9h 20m
1 stop
STL11:41 pmLambert-St Louis
$403
Find similar
Delta
Oct 13
STL6:00 amLambert-St Louis
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
Oct 25
PTY2:21 pmPanama City Tocumen Intl
17h 44m
1 stop
STL8:05 amLambert-St Louis
$462
Find similar

United Airlines flights from St. Louis to Panama City

Our best United Airlines deals on St. Louis to Panama City flight tickets
United Airlines
Oct 14
STL6:15 amLambert-St Louis
7h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Oct 22
PTY10:00 amPanama City Tocumen Intl
8h 57m
1 stop
STL6:57 pmLambert-St Louis
$393
Find similar
United Airlines
Oct 13
STL6:15 amLambert-St Louis
12h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Oct 20
PTY3:30 pmPanama City Tocumen Intl
19h 19m
2 stops
STL10:49 amLambert-St Louis
$398
Find similar
United Airlines
Oct 23
STL6:15 amLambert-St Louis
12h 22m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Oct 27
PTY3:41 pmPanama City Tocumen Intl
27h 06m
1 stop
STL6:47 pmLambert-St Louis
$401
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

6:00 am-12:56 pm

1 stop6h 56m

Panama City Tocumen Intl

Thu 10/23

2:21 pm-11:41 pm

1 stop9h 20m

$386

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 10/14

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Wed 10/22

10:00 am-6:57 pm

1 stop8h 57m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 10/20

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 10/14

3:03 pm-2:03 pm

2 stops23h 00m

Panama City Tocumen Intl

Thu 10/23

3:15 pm-9:35 am

2 stops18h 20m

$399

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/23

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 10/27

3:41 pm-6:47 pm

1 stop27h 06m

$401

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 10/13

6:00 am-12:56 pm

1 stop6h 56m

Panama City Tocumen Intl

Fri 10/24

2:21 pm-11:41 pm

1 stop9h 20m

$403

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 10/17

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 10/21

10:00 am-10:00 pm

1 stop12h 00m

$410

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 10/17

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Thu 10/23

3:30 pm-10:49 am

2 stops19h 19m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 10/23

6:08 pm-2:03 pm

1 stop19h 55m

Panama City Tocumen Intl

Mon 10/27

3:15 pm-9:28 am

2 stops18h 13m

$473

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 10/15

3:03 pm-2:03 pm

2 stops23h 00m

Panama City Tocumen Intl

Thu 10/23

3:15 pm-12:05 pm

2 stops20h 50m

$480

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Panama City?

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from St. Louis to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $441. If you’re not able to fly to Panama City in April, then May is your next best option. Flight prices from St. Louis to Panama City during May average around $506.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $509. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $607. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from St. Louis to Panama City during this time can be as low as $512. Try not to purchase tickets in the evening because they tend to be around $691. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $550 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from St. Louis for as low as $456 on momondo.

When to book flights from St. Louis to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City (STL to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City

Direct flights

None
There are no direct flights from St. Louis to Panama City. There are no popular flight routes from St. Louis to Panama City.
Search flight deals

  • How far is Lambert-St Louis to Panama City Tocumen Intl by plane?

    There are 2151.1 mi between Lambert-St Louis and Panama City Tocumen Intl. Flights usually cover this in 6h 56m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Panama City?

Best airlines flying from St. Louis to Panama City

Compare and see reviews for airlines that fly from St. Louis to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $373Free CancellationRating
7.9
7,957 reviews
Search Delta flights
United AirlinesPriceFrom $401Free CancellationRating
7.4
8,924 reviews
Search United Airlines flights
American AirlinesPriceFrom $410Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from St. Louis are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Panama City trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 10/16
Thu 10/23
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Panama