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Cheap flights from St. Louis to Panama City from $200

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 4/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
10:09 am - 6:37 pm
STL
-
PTY
8h 28m
1 stop
United Airlines Logo
10:00 am - 10:28 pm
PTY
-
STL
12h 28m
1 stop
$465United Airlines
Wed, Apr 15 - Mon, Apr 20
United Airlines Logo
6:30 am - 7:31 pm
STL
-
PTY
13h 01m
2 stops
United Airlines Logo
3:30 pm - 8:25 am
PTY
-
STL
16h 55m
2 stops
$469United Airlines
Wed, Apr 15 - Mon, Apr 20
United Airlines Logo
6:00 am - 2:14 pm
STL
-
PTY
8h 14m
1 stop
United Airlines Logo
7:55 am - 10:30 pm
PTY
-
STL
14h 35m
1 stop
$482United Airlines
Sat, Apr 25 - Tue, May 5
United Airlines Logo
6:00 am - 6:37 pm
STL
-
PTY
12h 37m
1 stop
United Airlines Logo
7:55 am - 10:30 pm
PTY
-
STL
14h 35m
1 stop
$485United Airlines
Tue, May 5 - Wed, May 13
United Airlines Logo
6:00 am - 4:12 pm
STL
-
PTY
10h 12m
1 stop
United Airlines Logo
3:30 pm - 8:25 am
PTY
-
STL
16h 55m
2 stops
$486United Airlines
Thu, Apr 9 - Sun, Apr 12
Copa Airlines Logo
11:10 am - 6:37 pm
STL
-
PTY
7h 27m
1 stop
Copa Airlines Logo
3:30 pm - 10:07 am
PTY
-
STL
18h 37m
1 stop
$487Copa Airlines
Tue, Jun 2 - Tue, Jul 14
United Airlines Logo
7:09 pm - 4:12 pm
STL
-
PTY
21h 03m
2 stops
United Airlines Logo
7:55 am - 10:45 pm
PTY
-
STL
14h 50m
2 stops
$489United Airlines
Tue, May 5 - Wed, May 13
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
American Airlines Logo
1:49 pm - 8:54 am
PTY
-
STL
19h 05m
2 stops
$491American Airlines
Sun, Apr 19 - Wed, Apr 22
United Airlines Logo
6:00 am - 6:37 pm
STL
-
PTY
12h 37m
1 stop
United Airlines Logo
3:30 pm - 8:25 am
PTY
-
STL
16h 55m
2 stops
$493United Airlines
Tue, Apr 21 - Sat, Apr 25
United Airlines Logo
6:30 pm - 2:14 pm
STL
-
PTY
19h 44m
1 stop
United Airlines Logo
7:55 am - 5:49 pm
PTY
-
STL
9h 54m
1 stop
$494United Airlines
Mon, Jun 1 - Tue, Aug 11

American Airlines flights from St. Louis to Panama City

Our best American Airlines deals on St. Louis to Panama City flight tickets
American Airlines
Apr 19
STL5:24 amLambert-St Louis
7h 22m
1 stop
PTY12:46 pmPanama City Tocumen Intl
Apr 22
PTY1:49 pmPanama City Tocumen Intl
8h 35m
1 stop
STL10:24 pmLambert-St Louis
$491
American Airlines
May 19
STL3:42 pmLambert-St Louis
21h 04m
2 stops
PTY12:46 pmPanama City Tocumen Intl
May 26
PTY1:14 pmPanama City Tocumen Intl
21h 20m
1 stop
STL10:34 amLambert-St Louis
$501
American Airlines
May 14
STL6:54 pmLambert-St Louis
17h 52m
2 stops
PTY12:46 pmPanama City Tocumen Intl
May 17
PTY1:49 pmPanama City Tocumen Intl
21h 20m
2 stops
STL11:09 amLambert-St Louis
$511

Copa Airlines flights from St. Louis to Panama City

Our best Copa Airlines deals on St. Louis to Panama City flight tickets
Copa Airlines
Jun 2
STL11:10 amLambert-St Louis
7h 27m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Jul 14
PTY3:30 pmPanama City Tocumen Intl
18h 37m
1 stop
STL10:07 amLambert-St Louis
$487
Copa Airlines
Jul 30
STL8:35 pmLambert-St Louis
17h 39m
2 stops
PTY2:14 pmPanama City Tocumen Intl
Aug 2
PTY9:45 amPanama City Tocumen Intl
14h 00m
1 stop
STL11:45 pmLambert-St Louis
$525

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 14, 2026.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/15

10:09 am-6:37 pm

1 stop8h 28m

Panama City Tocumen Intl

Mon 4/20

10:00 am-10:28 pm

1 stop12h 28m

$465

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/15

6:30 am-7:31 pm

2 stops13h 01m

Panama City Tocumen Intl

Mon 4/20

3:30 pm-8:25 am

2 stops16h 55m

$469

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 4/25

6:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Tue 5/5

7:55 am-10:30 pm

1 stop14h 35m

$482

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 5/5

6:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Wed 5/13

7:55 am-10:30 pm

1 stop14h 35m

$485

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 4/9

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Sun 4/12

3:30 pm-8:25 am

2 stops16h 55m

$486

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 6/2

11:10 am-6:37 pm

1 stop7h 27m

Panama City Tocumen Intl

Tue 7/14

3:30 pm-10:07 am

1 stop18h 37m

$487

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 5/5

7:09 pm-4:12 pm

2 stops21h 03m

Panama City Tocumen Intl

Wed 5/13

7:55 am-10:45 pm

2 stops14h 50m

$489

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 4/19

5:24 am-12:46 pm

1 stop7h 22m

Panama City Tocumen Intl

Wed 4/22

1:49 pm-8:54 am

2 stops19h 05m

$491

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 4/21

6:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Sat 4/25

3:30 pm-8:25 am

2 stops16h 55m

$493

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 6/1

6:30 pm-2:14 pm

1 stop19h 44m

Panama City Tocumen Intl

Tue 8/11

7:55 am-5:49 pm

1 stop9h 54m

$494

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from St. Louis to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $459. If you’re not able to fly to Panama City in April, then May is your next best option. Flight prices from St. Louis to Panama City during May average around $510.

Can stopping save me money on St. Louis to Panama City flights?

You could potentially save up to 39% on your flight if you consider stops on a St. Louis to Panama City flight.

When to book flights from St. Louis to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City (STL to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City

Fastest flight time

7h 37m

Direct flights

None
The fastest flight from St. Louis to Panama City takes 7h 37m
There are no direct flights from St. Louis to Panama City. There are no popular flight routes from St. Louis to Panama City.
Search flight deals

  • How far is Lambert-St Louis to Panama City Tocumen Intl by plane?

    There are 2151.1 mi between Lambert-St Louis and Panama City Tocumen Intl. Flights usually cover this in 7h 37m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Panama City?

Best airlines flying from St. Louis to Panama City

Compare and see reviews for airlines that fly from St. Louis to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $227Free CancellationRating
7.9
8,291 reviews
Search Delta flights
United AirlinesPriceFrom $393Free CancellationRating
7.4
9,423 reviews
Search United Airlines flights
American AirlinesPriceFrom $393Free CancellationRating
7.1
11,464 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from St. Louis are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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