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Cheap flights from St. Louis to Panama City from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 9/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

American Airlines Logo
5:28 am - 2:31 pmSTL-PTY
9h 03m1 stop
American Airlines Logo
3:31 pm - 11:59 pmPTY-STL
8h 28m1 stop
$393American Airlines
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Fri, Sep 12 - Fri, Sep 19
United Airlines Logo
6:15 am - 2:45 pmSTL-PTY
7h 30m1 stop
United Airlines Logo
4:41 pm - 10:51 amPTY-STL
19h 10m2 stops
$398United Airlines
Find Deal
Thu, Nov 6 - Thu, Nov 13
United Airlines Logo
6:43 pm - 2:45 pmSTL-PTY
19h 02m2 stops
United Airlines Logo
8:55 am - 10:45 pmPTY-STL
14h 50m2 stops
$415United Airlines
Find Deal
Sun, Nov 23 - Fri, Nov 28
United Airlines Logo
11:20 am - 2:45 pmSTL-PTY
26h 25m1 stop
United Airlines Logo
8:55 am - 6:46 pmPTY-STL
10h 51m1 stop
$418United Airlines
Find Deal
Sun, Nov 23 - Fri, Nov 28
United Airlines Logo
11:05 am - 6:37 pmSTL-PTY
7h 32m1 stop
United Airlines Logo
3:30 pm - 6:58 pmPTY-STL
27h 28m1 stop
$419United Airlines
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Wed, Sep 3 - Sun, Sep 7
American Airlines Logo
5:28 am - 12:55 pmSTL-PTY
7h 27m1 stop
American Airlines Logo
3:31 pm - 12:23 pmPTY-STL
20h 52m2 stops
$420American Airlines
Find Deal
Wed, Sep 3 - Sun, Sep 7
United Airlines Logo
6:43 pm - 2:45 pmSTL-PTY
19h 02m2 stops
United Airlines Logo
4:41 pm - 9:59 pmPTY-STL
30h 18m1 stop
$423United Airlines
Find Deal
Sun, Nov 9 - Sun, Nov 16
United Airlines Logo
8:20 am - 6:37 pmSTL-PTY
10h 17m1 stop
United Airlines Logo
10:00 am - 10:08 pmPTY-STL
12h 08m1 stop
$427United Airlines
Find Deal
Fri, Sep 12 - Fri, Sep 19
United Airlines Logo
8:20 am - 6:37 pmSTL-PTY
10h 17m1 stop
United Airlines Logo
3:30 pm - 2:19 pmPTY-STL
22h 49m2 stops
$432United Airlines
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Fri, Sep 12 - Fri, Sep 19
Logo
10:35 am - 8:19 pmSTL-PTY
9h 44m1 stop
Logo
3:20 am - 1:02 pmPTY-STL
33h 42m2 stops
$824
Find Deal
Sun, Sep 14 - Sat, Sep 20

United Airlines flights from St. Louis to Panama City

Our best United Airlines deals on St. Louis to Panama City flight tickets
United Airlines
Nov 6
STL6:15 amLambert-St Louis
7h 30m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Nov 13
PTY4:41 pmPanama City Tocumen Intl
19h 10m
2 stops
STL10:51 amLambert-St Louis
$398
Find similar
United Airlines
Nov 23
STL6:43 pmLambert-St Louis
19h 02m
2 stops
PTY2:45 pmPanama City Tocumen Intl
Nov 28
PTY8:55 amPanama City Tocumen Intl
14h 50m
2 stops
STL10:45 pmLambert-St Louis
$415
Find similar
United Airlines
Nov 23
STL11:20 amLambert-St Louis
26h 25m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Nov 28
PTY8:55 amPanama City Tocumen Intl
10h 51m
1 stop
STL6:46 pmLambert-St Louis
$418
Find similar

American Airlines flights from St. Louis to Panama City

Our best American Airlines deals on St. Louis to Panama City flight tickets
American Airlines
Sep 12
STL5:28 amLambert-St Louis
9h 03m
1 stop
PTY2:31 pmPanama City Tocumen Intl
Sep 19
PTY3:31 pmPanama City Tocumen Intl
8h 28m
1 stop
STL11:59 pmLambert-St Louis
$393
Find similar
American Airlines
Sep 3
STL5:28 amLambert-St Louis
7h 27m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Sep 7
PTY3:31 pmPanama City Tocumen Intl
20h 52m
2 stops
STL12:23 pmLambert-St Louis
$420
Find similar
American Airlines
Sep 14
STL4:36 pmLambert-St Louis
21h 55m
2 stops
PTY2:31 pmPanama City Tocumen Intl
Sep 21
PTY3:31 pmPanama City Tocumen Intl
21h 20m
2 stops
STL12:51 pmLambert-St Louis
$437
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momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/12

5:28 am-2:31 pm

1 stop9h 03m

Panama City Tocumen Intl

Fri 9/19

3:31 pm-11:59 pm

1 stop8h 28m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 11/6

6:15 am-2:45 pm

1 stop7h 30m

Panama City Tocumen Intl

Thu 11/13

4:41 pm-10:51 am

2 stops19h 10m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 11/23

6:43 pm-2:45 pm

2 stops19h 02m

Panama City Tocumen Intl

Fri 11/28

8:55 am-10:45 pm

2 stops14h 50m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 11/23

11:20 am-2:45 pm

1 stop26h 25m

Panama City Tocumen Intl

Fri 11/28

8:55 am-6:46 pm

1 stop10h 51m

$418

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 9/3

11:05 am-6:37 pm

1 stop7h 32m

Panama City Tocumen Intl

Sun 9/7

3:30 pm-6:58 pm

1 stop27h 28m

$419

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 9/3

5:28 am-12:55 pm

1 stop7h 27m

Panama City Tocumen Intl

Sun 9/7

3:31 pm-12:23 pm

2 stops20h 52m

$420

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 11/9

6:43 pm-2:45 pm

2 stops19h 02m

Panama City Tocumen Intl

Sun 11/16

4:41 pm-9:59 pm

1 stop30h 18m

$423

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/12

8:20 am-6:37 pm

1 stop10h 17m

Panama City Tocumen Intl

Fri 9/19

10:00 am-10:08 pm

1 stop12h 08m

$427

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/12

8:20 am-6:37 pm

1 stop10h 17m

Panama City Tocumen Intl

Fri 9/19

3:30 pm-2:19 pm

2 stops22h 49m

$432

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 9/14

10:35 am-8:19 pm

1 stop9h 44m

Panama City Tocumen Intl

Sat 9/20

3:20 am-1:02 pm

2 stops33h 42m

$824

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from St. Louis to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $441. If you’re not able to fly to Panama City in April, then October is your next best option. Flight prices from St. Louis to Panama City during October average around $469.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $509. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $607. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from St. Louis to Panama City during this time can be as low as $512. Try not to purchase tickets in the evening because they tend to be around $691. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $543 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from St. Louis for as low as $451 on momondo.

When to book flights from St. Louis to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City (STL to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City

Best Price Found

$164

Fastest flight time

7h 18m

Direct flights

None

Airports in Panama City

1 airport
The best one-way flight to Panama City from St. Louis in the past 72 hours is $164. The best round-trip flight deal from St. Louis to Panama City found on momondo in the last 72 hours is $393.
The fastest flight from St. Louis to Panama City takes 7h 18m
There are no direct flights from St. Louis to Panama City. Popular non-direct route for this connection is Lambert-St Louis Airport - Panama City Tocumen Intl Airport.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
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  • How far is Lambert-St Louis to Panama City Tocumen Intl by plane?

    There are 2151.1 mi between Lambert-St Louis and Panama City Tocumen Intl. Flights usually cover this in 7h 18m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Panama City?

Best airlines flying from St. Louis to Panama City

Compare and see reviews for airlines that fly from St. Louis to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $373Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $410Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $435Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from St. Louis are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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