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Cheap flights from St. Louis to Panama City from $394

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 2/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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United Airlines Logo
10:10 am - 7:38 pmSTL-PTY
8h 28m1 stop
United Airlines Logo
4:41 pm - 9:23 amPTY-STL
17h 42m1 stop
$394United Airlines
Find Deal
Tue, Feb 17 - Wed, Feb 25
United Airlines Logo
6:00 am - 7:38 pmSTL-PTY
12h 38m1 stop
United Airlines Logo
8:55 am - 10:00 pmPTY-STL
14h 05m2 stops
$398United Airlines
Find Deal
Tue, Feb 17 - Wed, Feb 25
American Airlines Logo
6:02 pm - 1:27 pmSTL-PTY
18h 25m1 stop
American Airlines Logo
4:50 pm - 9:08 amPTY-STL
17h 18m1 stop
$403American Airlines
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Mon, Jan 19 - Fri, Jan 23
United Airlines Logo
6:00 am - 5:07 pmSTL-PTY
10h 07m1 stop
United Airlines Logo
4:41 pm - 9:22 amPTY-STL
17h 41m1 stop
$411United Airlines
Find Deal
Fri, Jan 23 - Tue, Jan 27
American Airlines Logo
7:03 pm - 12:15 pmSTL-PTY
17h 12m2 stops
American Airlines Logo
1:55 pm - 9:35 pmPTY-STL
7h 40m1 stop
$415American Airlines
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Fri, Apr 10 - Fri, Apr 17
United Airlines Logo
10:07 am - 5:07 pmSTL-PTY
30h 00m1 stop
United Airlines Logo
4:41 pm - 9:23 amPTY-STL
17h 42m1 stop
$419United Airlines
Find Deal
Tue, Feb 10 - Sat, Feb 14
American Airlines Logo
5:04 pm - 1:27 pmSTL-PTY
19h 23m2 stops
American Airlines Logo
4:50 pm - 9:24 amPTY-STL
17h 34m2 stops
$420American Airlines
Find Deal
Mon, Jan 12 - Sun, Jan 18
United Airlines Logo
6:15 am - 2:45 pmSTL-PTY
7h 30m1 stop
United Airlines Logo
4:41 pm - 9:49 amPTY-STL
18h 08m1 stop
$428United Airlines
Find Deal
Sun, Dec 14 - Sun, Dec 21
American Airlines Logo
6:02 pm - 1:27 pmSTL-PTY
18h 25m1 stop
American Airlines Logo
4:50 pm - 9:24 amPTY-STL
17h 34m2 stops
$430American Airlines
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Mon, Jan 12 - Sun, Jan 18
Multiple Airlines Logo
10:42 am - 8:34 pmSTL-PTY
8h 52m1 stop
Multiple Airlines Logo
2:55 am - 7:50 amPTY-STL
29h 55m2 stops
$744Multiple Airlines
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Sun, Jan 18 - Sat, Jan 24

American Airlines flights from St. Louis to Panama City

Our best American Airlines deals on St. Louis to Panama City flight tickets
American Airlines
Jan 19
STL6:02 pmLambert-St Louis
18h 25m
1 stop
PTY1:27 pmPanama City Tocumen Intl
Jan 23
PTY4:50 pmPanama City Tocumen Intl
17h 18m
1 stop
STL9:08 amLambert-St Louis
$403
Find similar
American Airlines
Apr 10
STL7:03 pmLambert-St Louis
17h 12m
2 stops
PTY12:15 pmPanama City Tocumen Intl
Apr 17
PTY1:55 pmPanama City Tocumen Intl
7h 40m
1 stop
STL9:35 pmLambert-St Louis
$415
Find similar
American Airlines
Jan 12
STL5:04 pmLambert-St Louis
19h 23m
2 stops
PTY1:27 pmPanama City Tocumen Intl
Jan 18
PTY4:50 pmPanama City Tocumen Intl
17h 34m
2 stops
STL9:24 amLambert-St Louis
$420
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United Airlines flights from St. Louis to Panama City

Our best United Airlines deals on St. Louis to Panama City flight tickets
United Airlines
Feb 17
STL10:10 amLambert-St Louis
8h 28m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Feb 25
PTY4:41 pmPanama City Tocumen Intl
17h 42m
1 stop
STL9:23 amLambert-St Louis
$394
Find similar
United Airlines
Feb 17
STL6:00 amLambert-St Louis
12h 38m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Feb 25
PTY8:55 amPanama City Tocumen Intl
14h 05m
2 stops
STL10:00 pmLambert-St Louis
$398
Find similar
United Airlines
Jan 23
STL6:00 amLambert-St Louis
10h 07m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Jan 27
PTY4:41 pmPanama City Tocumen Intl
17h 41m
1 stop
STL9:22 amLambert-St Louis
$411
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

10:10 am-7:38 pm

1 stop8h 28m

Panama City Tocumen Intl

Wed 2/25

4:41 pm-9:23 am

1 stop17h 42m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Wed 2/25

8:55 am-10:00 pm

2 stops14h 05m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 1/19

6:02 pm-1:27 pm

1 stop18h 25m

Panama City Tocumen Intl

Fri 1/23

4:50 pm-9:08 am

1 stop17h 18m

$403

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 1/23

6:00 am-5:07 pm

1 stop10h 07m

Panama City Tocumen Intl

Tue 1/27

4:41 pm-9:22 am

1 stop17h 41m

$411

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 4/10

7:03 pm-12:15 pm

2 stops17h 12m

Panama City Tocumen Intl

Fri 4/17

1:55 pm-9:35 pm

1 stop7h 40m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/10

10:07 am-5:07 pm

1 stop30h 00m

Panama City Tocumen Intl

Sat 2/14

4:41 pm-9:23 am

1 stop17h 42m

$419

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 1/12

5:04 pm-1:27 pm

2 stops19h 23m

Panama City Tocumen Intl

Sun 1/18

4:50 pm-9:24 am

2 stops17h 34m

$420

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 12/14

6:15 am-2:45 pm

1 stop7h 30m

Panama City Tocumen Intl

Sun 12/21

4:41 pm-9:49 am

1 stop18h 08m

$428

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 1/12

6:02 pm-1:27 pm

1 stop18h 25m

Panama City Tocumen Intl

Sun 1/18

4:50 pm-9:24 am

2 stops17h 34m

$430

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 1/18

10:42 am-8:34 pm

1 stop8h 52m

Panama City Tocumen Intl

Sat 1/24

2:55 am-7:50 am

2 stops29h 55m

$744

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Panama City?

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from St. Louis to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $441. If you’re not able to fly to Panama City in April, then May is your next best option. Flight prices from St. Louis to Panama City during May average around $504.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $509. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $607. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the afternoon. Flights from St. Louis to Panama City during this time can be as low as $512. Try not to purchase tickets in the evening because they tend to be around $691. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $548 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from St. Louis for as low as $410 on momondo.

When to book flights from St. Louis to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City (STL to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City

Direct flights

None
There are no direct flights from St. Louis to Panama City. There are no popular flight routes from St. Louis to Panama City.
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  • How far is Lambert-St Louis to Panama City Tocumen Intl by plane?

    There are 2151.1 mi between Lambert-St Louis and Panama City Tocumen Intl. Flights usually cover this in 6h 40m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Panama City?

Best airlines flying from St. Louis to Panama City

Compare and see reviews for airlines that fly from St. Louis to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $373Free CancellationRating
7.9
8,004 reviews
Search Delta flights
American AirlinesPriceFrom $394Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights
United AirlinesPriceFrom $401Free CancellationRating
7.4
9,002 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from St. Louis are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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