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Cheap flights from St. Louis to Panama City from $290

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 10/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 12:58 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
6h 58m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:23 pm - 11:42 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 19m1 stop Atlanta Hartsfield-Jackson
$645Delta
Mon, Sep 21 - Mon, Oct 5
Delta Logo
6:00 am - 12:58 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
6h 58m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:23 pm - 11:42 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 19m1 stop Atlanta Hartsfield-Jackson
$645Delta
Tue, Sep 22 - Mon, Oct 5
United Airlines Logo
6:15 am - 2:14 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
7h 59m1 stop Houston George Bush Intcntl
United Airlines Logo
10:00 am - 10:30 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
12h 30m1 stop Houston George Bush Intcntl
$645United Airlines
Thu, Sep 24 - Thu, Oct 8
United Airlines Logo
7:00 am - 7:31 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
12h 31m1 stop Newark
United Airlines Logo
3:30 pm - 12:13 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
20h 43m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$645United Airlines
Wed, Sep 23 - Wed, Oct 7
American Airlines Logo
5:45 pm - 12:16 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
18h 31m2 stops Philadelphia Miami
American Airlines Logo
1:16 pm - 10:18 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
21h 02m2 stops Miami Chicago O'Hare Intl
$649American Airlines
Thu, Sep 10 - Wed, Sep 16
American Airlines Logo
5:00 am - 12:26 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
7h 26m1 stop Miami
American Airlines Logo
1:16 pm - 11:59 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
10h 43m1 stop Miami
$650American Airlines
Wed, Sep 9 - Fri, Sep 11
Multiple Airlines Logo
2:29 pm - 8:31 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
30h 02m1 stop Atlanta Hartsfield-Jackson
Multiple Airlines Logo
9:33 pm - 9:40 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
36h 07m2 stops Miami Atlanta Hartsfield-Jackson
$739Multiple Airlines
Mon, Sep 21 - Sat, Oct 10
Multiple Airlines Logo
2:29 pm - 8:31 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
30h 02m1 stop Atlanta Hartsfield-Jackson
Multiple Airlines Logo
10:25 am - 9:40 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
23h 15m2 stops Miami Atlanta Hartsfield-Jackson
$743Multiple Airlines
Fri, Sep 25 - Wed, Oct 7
Copa Airlines Logo
11:00 am - 7:38 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
7h 38m1 stop Houston George Bush Intcntl
Copa Airlines Logo
4:41 pm - 10:06 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
30h 25m1 stop Houston George Bush Intcntl
$808Copa Airlines
Fri, Jan 8 - Sun, Jan 17
Copa Airlines Logo
6:15 am - 7:38 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
12h 23m1 stop Houston George Bush Intcntl
Copa Airlines Logo
4:41 pm - 10:06 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
30h 25m1 stop Houston George Bush Intcntl
$829Copa Airlines
Fri, Jan 8 - Sun, Jan 17

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United Airlines flights from St. Louis to Panama City

Our best United Airlines deals on St. Louis to Panama City flight tickets
United Airlines
Sep 22
STL7:00 amLambert-St Louis
12h 31m
1 stop
PTY7:31 pmPanama City Tocumen Intl
Oct 8
PTY3:30 pmPanama City Tocumen Intl
20h 43m
2 stops
STL12:13 pmLambert-St Louis
$645
United Airlines
Sep 20
STL5:30 pmLambert-St Louis
20h 44m
2 stops
PTY2:14 pmPanama City Tocumen Intl
Oct 6
PTY10:00 amPanama City Tocumen Intl
10h 16m
1 stop
STL8:16 pmLambert-St Louis
$649
United Airlines
Sep 24
STL7:30 amLambert-St Louis
12h 01m
1 stop
PTY7:31 pmPanama City Tocumen Intl
Oct 1
PTY3:30 pmPanama City Tocumen Intl
18h 40m
1 stop
STL10:10 amLambert-St Louis
$655

Delta flights from St. Louis to Panama City

Our best Delta deals on St. Louis to Panama City flight tickets
Delta
Sep 20
STL4:59 pmLambert-St Louis
19h 59m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Oct 7
PTY2:24 pmPanama City Tocumen Intl
9h 30m
1 stop
STL11:54 pmLambert-St Louis
$654
Delta
Nov 20
STL6:00 amLambert-St Louis
7h 05m
1 stop
PTY2:05 pmPanama City Tocumen Intl
Nov 26
PTY3:30 pmPanama City Tocumen Intl
8h 26m
1 stop
STL10:56 pmLambert-St Louis
$733
Delta
Aug 22
STL6:00 amLambert-St Louis
7h 05m
1 stop
PTY1:05 pmPanama City Tocumen Intl
Aug 29
PTY2:30 pmPanama City Tocumen Intl
9h 01m
1 stop
STL11:31 pmLambert-St Louis
$851

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Mon 9/21

6:00 am-12:58 pm

1 stop6h 58m

Panama City Tocumen Intl

Mon 10/5

2:23 pm-11:42 pm

1 stop9h 19m

$645

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Tue 9/22

6:00 am-12:58 pm

1 stop6h 58m

Panama City Tocumen Intl

Mon 10/5

2:23 pm-11:42 pm

1 stop9h 19m

$645

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Thu 9/24

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Thu 10/8

10:00 am-10:30 pm

1 stop12h 30m

$645

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Wed 9/23

7:00 am-7:31 pm

1 stop12h 31m

Panama City Tocumen Intl

Wed 10/7

3:30 pm-12:13 pm

2 stops20h 43m

$645

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Thu 9/10

5:45 pm-12:16 pm

2 stops18h 31m

Panama City Tocumen Intl

Wed 9/16

1:16 pm-10:18 am

2 stops21h 02m

$649

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Wed 9/9

5:00 am-12:26 pm

1 stop7h 26m

Panama City Tocumen Intl

Fri 9/11

1:16 pm-11:59 pm

1 stop10h 43m

$650

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Mon 9/21

2:29 pm-8:31 pm

1 stop30h 02m

Panama City Tocumen Intl

Sat 10/10

9:33 pm-9:40 am

2 stops36h 07m

$739

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Fri 9/25

2:29 pm-8:31 pm

1 stop30h 02m

Panama City Tocumen Intl

Wed 10/7

10:25 am-9:40 am

2 stops23h 15m

$743

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Fri 1/8

11:00 am-7:38 pm

1 stop7h 38m

Panama City Tocumen Intl

Sun 1/17

4:41 pm-10:06 pm

1 stop30h 25m

$808

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Fri 1/8

6:15 am-7:38 pm

1 stop12h 23m

Panama City Tocumen Intl

Sun 1/17

4:41 pm-10:06 pm

1 stop30h 25m

$829

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Panama City?

Prices are currently low for flights on this route.

Typical prices usually range from $704 to $754.
The lowest price recently found on this route was $645.

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from St. Louis to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $495. If you’re not able to fly to Panama City in April, then November is your next best option. Flight prices from St. Louis to Panama City during November average around $547.

Can stopping save me money on St. Louis to Panama City flights?

You could potentially save up to 22% on your flight if you consider stops on a St. Louis to Panama City flight.

When to book flights from St. Louis to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City (STL to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City

Fastest flight time

7h 05m

Direct flights

None
The fastest flight from St. Louis to Panama City takes 7h 05m
There are no direct flights from St. Louis to Panama City. There are no popular flight routes from St. Louis to Panama City.
Search flight deals

Frequently asked questions about flying from St. Louis to Panama City

  • How far is Lambert-St Louis to Panama City Tocumen Intl by plane?

    There are 2151.1 mi between Lambert-St Louis and Panama City Tocumen Intl. Flights usually cover this in 7h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Panama City?

Best airlines flying from St. Louis to Panama City

Compare and see reviews for airlines that fly from St. Louis to Panama City with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $393Free CancellationRating
7.1
11,927 reviews
Search American Airlines flights
United AirlinesPriceFrom $393Free CancellationRating
7.4
10,112 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $446Free CancellationRating
7.6
1,559 reviews
Search Copa Airlines flights
DeltaPriceFrom $478Free CancellationRating
7.8
8,504 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from St. Louis are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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