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Cheap flights from St. Louis to Panama City from $358

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
8:50 am - 7:38 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
9h 48m1 stop Houston George Bush Intcntl
United Airlines Logo
11:35 am - 10:13 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
11h 38m1 stop Houston George Bush Intcntl
$607United Airlines
Mon, Jan 18 - Tue, Jan 26
United Airlines Logo
6:15 am - 5:12 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
9h 57m1 stop Houston George Bush Intcntl
United Airlines Logo
8:55 am - 10:13 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
14h 18m1 stop Houston George Bush Intcntl
$607United Airlines
Tue, Jan 19 - Thu, Jan 28
American Airlines Logo
4:12 pm - 2:13 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
21h 01m2 stops New York LaGuardia Miami
American Airlines Logo
3:13 pm - 8:21 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
18h 08m2 stops Miami Charlotte Douglas
$611American Airlines
Tue, Dec 1 - Wed, Dec 9
American Airlines Logo
4:12 pm - 2:13 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
21h 01m2 stops New York LaGuardia Miami
American Airlines Logo
3:13 pm - 8:21 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
18h 08m2 stops Miami Charlotte Douglas
$611American Airlines
Tue, Dec 1 - Wed, Dec 9
Delta Logo
6:00 am - 12:59 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
6h 59m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:24 pm - 11:54 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 30m1 stop Atlanta Hartsfield-Jackson
$702Delta
Fri, Oct 23 - Wed, Oct 28
Delta Logo
6:00 am - 1:59 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
6h 59m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:29 pm - 11:56 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 27m1 stop Atlanta Hartsfield-Jackson
$702Delta
Fri, Nov 6 - Tue, Nov 10
Copa Airlines Logo
9:35 am - 2:45 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
28h 10m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
Copa Airlines Logo
11:35 am - 10:30 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
11h 55m1 stop Houston George Bush Intcntl
$730Copa Airlines
Tue, Dec 22 - Mon, Dec 28
Copa Airlines Logo
6:58 pm - 7:38 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
23h 40m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
Copa Airlines Logo
4:41 pm - 10:42 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
19h 01m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$750Copa Airlines
Tue, Dec 22 - Mon, Dec 28
GOL Logo
5:00 am - 1:02 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
8h 02m1 stop Miami
GOL Logo
3:13 pm - 9:30 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
19h 17m2 stops Miami Dallas/Fort Worth
$822GOL
Sat, Oct 31 - Fri, Nov 6
Multiple Airlines Logo
4:26 pm - 2:10 amSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
32h 44m3 stops Orlando Dallas/Fort Worth San Salvador El Salvador Intl
Multiple Airlines Logo
5:30 am - 3:23 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
34h 53m3 stops San Salvador El Salvador Intl Dallas/Fort Worth Denver Intl
$981Multiple Airlines
Fri, Nov 6 - Tue, Nov 10

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American Airlines flights from St. Louis to Panama City

Our best American Airlines deals on St. Louis to Panama City flight tickets
American Airlines
Nov 5
STL6:15 pmLambert-St Louis
18h 58m
1 stop
PTY2:13 pmPanama City Tocumen Intl
Nov 12
PTY3:13 pmPanama City Tocumen Intl
18h 29m
2 stops
STL8:42 amLambert-St Louis
$665
American Airlines
Nov 5
STL6:15 pmLambert-St Louis
18h 58m
1 stop
PTY2:13 pmPanama City Tocumen Intl
Nov 10
PTY3:13 pmPanama City Tocumen Intl
19h 34m
2 stops
STL9:47 amLambert-St Louis
$704
American Airlines
Oct 22
STL5:08 pmLambert-St Louis
19h 54m
2 stops
PTY1:02 pmPanama City Tocumen Intl
Oct 26
PTY2:02 pmPanama City Tocumen Intl
20h 16m
2 stops
STL10:18 amLambert-St Louis
$711

United Airlines flights from St. Louis to Panama City

Our best United Airlines deals on St. Louis to Panama City flight tickets
United Airlines
Dec 1
STL6:00 amLambert-St Louis
10h 12m
1 stop
PTY5:12 pmPanama City Tocumen Intl
Dec 9
PTY8:55 amPanama City Tocumen Intl
14h 35m
1 stop
STL10:30 pmLambert-St Louis
$607
United Airlines
Dec 1
STL6:00 amLambert-St Louis
10h 12m
1 stop
PTY5:12 pmPanama City Tocumen Intl
Dec 9
PTY4:41 pmPanama City Tocumen Intl
20h 41m
2 stops
STL12:22 pmLambert-St Louis
$611
United Airlines
Nov 18
STL9:59 amLambert-St Louis
9h 03m
1 stop
PTY8:02 pmPanama City Tocumen Intl
Dec 18
PTY10:00 amPanama City Tocumen Intl
13h 59m
1 stop
STL10:59 pmLambert-St Louis
$641

momondo Fare Finder

 
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

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Route

Depart

Return

Price

Cheapest round-trip

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Mon 1/18

8:50 am-7:38 pm

1 stop9h 48m

Panama City Tocumen Intl

Tue 1/26

11:35 am-10:13 pm

1 stop11h 38m

$607

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Tue 1/19

6:15 am-5:12 pm

1 stop9h 57m

Panama City Tocumen Intl

Thu 1/28

8:55 am-10:13 pm

1 stop14h 18m

$607

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Tue 12/1

4:12 pm-2:13 pm

2 stops21h 01m

Panama City Tocumen Intl

Wed 12/9

3:13 pm-8:21 am

2 stops18h 08m

$611

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Tue 12/1

4:12 pm-2:13 pm

2 stops21h 01m

Panama City Tocumen Intl

Wed 12/9

3:13 pm-8:21 am

2 stops18h 08m

$611

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Fri 10/23

6:00 am-12:59 pm

1 stop6h 59m

Panama City Tocumen Intl

Wed 10/28

2:24 pm-11:54 pm

1 stop9h 30m

$702
Quickest round-trip

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Fri 11/6

6:00 am-1:59 pm

1 stop6h 59m

Panama City Tocumen Intl

Tue 11/10

3:29 pm-11:56 pm

1 stop9h 27m

$702

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Tue 12/22

9:35 am-2:45 pm

2 stops28h 10m

Panama City Tocumen Intl

Mon 12/28

11:35 am-10:30 pm

1 stop11h 55m

$730

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Tue 12/22

6:58 pm-7:38 pm

2 stops23h 40m

Panama City Tocumen Intl

Mon 12/28

4:41 pm-10:42 am

2 stops19h 01m

$750

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Sat 10/31

5:00 am-1:02 pm

1 stop8h 02m

Panama City Tocumen Intl

Fri 11/6

3:13 pm-9:30 am

2 stops19h 17m

$822

St. LouisPanama City

STL Lambert-St Louis - PTY Panama City Tocumen Intl

STLPTY

Lambert-St Louis

Fri 11/6

4:26 pm-2:10 am

3 stops32h 44m

Panama City Tocumen Intl

Tue 11/10

5:30 am-3:23 pm

3 stops34h 53m

$981

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Panama City?

Prices are currently low for flights on this route.

Typical prices usually range from $611 to $1,256.
The lowest price recently found on this route was $607.

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from St. Louis to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $503. If you’re not able to fly to Panama City in April, then November is your next best option. Flight prices from St. Louis to Panama City during November average around $510.

How have St. Louis to Panama City flight prices changed over time?

As of September 2026, prices for St. Louis to Panama City flights are approximately 52% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City (STL to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City

Best Price Found

$358

Fastest flight time

6h 59m

Direct flights

None
The best one-way flight to Panama City from St. Louis in the past 72 hours is $358. The best round-trip flight deal from St. Louis to Panama City found on momondo in the last 72 hours is $607.
The fastest flight from St. Louis to Panama City takes 6h 59m
There are no direct flights from St. Louis to Panama City. There are no popular flight routes from St. Louis to Panama City.
Search flight deals

Frequently asked questions about flying from St. Louis to Panama City

  • How far is Lambert-St Louis to Panama City Tocumen Intl by plane?

    There are 2151.1 mi between Lambert-St Louis and Panama City Tocumen Intl. Flights usually cover this in 6h 59m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Panama City?

Best airlines flying from St. Louis to Panama City

Compare and see reviews for airlines that fly from St. Louis to Panama City with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $393Free CancellationRating
7.0
12,098 reviews
Search American Airlines flights
United AirlinesPriceFrom $393Free CancellationRating
7.4
10,243 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $446Free CancellationRating
7.6
1,544 reviews
Search Copa Airlines flights
DeltaPriceFrom $478Free CancellationRating
7.8
8,609 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

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Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

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