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Cheap flights from St. Louis to Panama City from $246

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 6/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 1:13 pm
STL
-
PTY
7h 13m
1 stop
Delta Logo
2:21 pm - 11:37 pm
PTY
-
STL
9h 16m
1 stop
$525Delta
Tue, Sep 8 - Tue, Sep 15
United Airlines Logo
6:14 am - 2:14 pm
STL
-
PTY
8h 00m
1 stop
United Airlines Logo
3:30 pm - 12:13 pm
PTY
-
STL
20h 43m
2 stops
$529United Airlines
Tue, Sep 8 - Tue, Sep 15
United Airlines Logo
6:01 am - 4:04 am
STL
-
PTY
22h 03m
1 stop
United Airlines Logo
9:45 am - 11:44 pm
PTY
-
STL
13h 59m
1 stop
$534United Airlines
Mon, Jul 20 - Wed, Jul 29
United Airlines Logo
6:01 am - 4:04 am
STL
-
PTY
22h 03m
1 stop
United Airlines Logo
3:30 pm - 8:37 am
PTY
-
STL
17h 07m
2 stops
$539United Airlines
Mon, Jul 6 - Wed, Aug 12
United Airlines Logo
6:00 am - 7:31 pm
STL
-
PTY
13h 31m
1 stop
United Airlines Logo
10:00 am - 10:45 pm
PTY
-
STL
12h 45m
1 stop
$542United Airlines
Thu, Jun 4 - Sun, Jun 7
United Airlines Logo
6:01 am - 4:04 am
STL
-
PTY
22h 03m
1 stop
United Airlines Logo
10:55 pm - 11:36 pm
PTY
-
STL
24h 41m
1 stop
$543United Airlines
Mon, Jul 20 - Mon, Jul 27
United Airlines Logo
11:10 am - 6:37 pm
STL
-
PTY
7h 27m
1 stop
United Airlines Logo
3:30 pm - 8:37 am
PTY
-
STL
17h 07m
2 stops
$546United Airlines
Sat, Aug 22 - Wed, Aug 26
American Airlines Logo
5:02 pm - 12:14 pm
STL
-
PTY
19h 12m
2 stops
American Airlines Logo
1:24 pm - 5:34 pm
PTY
-
STL
28h 10m
2 stops
$547American Airlines
Mon, Aug 3 - Fri, Aug 7
United Airlines Logo
8:35 am - 4:12 pm
STL
-
PTY
7h 37m
1 stop
United Airlines Logo
9:45 am - 11:36 pm
PTY
-
STL
13h 51m
1 stop
$549United Airlines
Tue, Jul 21 - Tue, Aug 4
Delta Logo
6:00 am - 1:05 pm
STL
-
PTY
7h 05m
1 stop
Delta Logo
2:20 pm - 9:20 am
PTY
-
STL
19h 00m
1 stop
$550Delta
Tue, Jul 28 - Fri, Aug 7

American Airlines flights from St. Louis to Panama City

Our best American Airlines deals on St. Louis to Panama City flight tickets
American Airlines
Aug 3
STL5:02 pmLambert-St Louis
19h 12m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Aug 7
PTY1:24 pmPanama City Tocumen Intl
28h 10m
2 stops
STL5:34 pmLambert-St Louis
$547
American Airlines
Aug 24
STL11:35 amLambert-St Louis
24h 49m
1 stop
PTY12:24 pmPanama City Tocumen Intl
Aug 31
PTY1:24 pmPanama City Tocumen Intl
9h 16m
1 stop
STL10:40 pmLambert-St Louis
$554
American Airlines
Jul 31
STL6:16 pmLambert-St Louis
17h 58m
2 stops
PTY12:14 pmPanama City Tocumen Intl
Aug 4
PTY1:14 pmPanama City Tocumen Intl
21h 31m
1 stop
STL10:45 amLambert-St Louis
$558

United Airlines flights from St. Louis to Panama City

Our best United Airlines deals on St. Louis to Panama City flight tickets
United Airlines
Sep 8
STL5:32 pmLambert-St Louis
20h 42m
2 stops
PTY2:14 pmPanama City Tocumen Intl
Sep 15
PTY9:45 amPanama City Tocumen Intl
13h 52m
1 stop
STL11:37 pmLambert-St Louis
$529
United Airlines
Jul 20
STL6:01 amLambert-St Louis
22h 03m
1 stop
PTY4:04 amPanama City Tocumen Intl
Jul 28
PTY9:45 amPanama City Tocumen Intl
13h 51m
1 stop
STL11:36 pmLambert-St Louis
$534
United Airlines
Jul 6
STL6:01 amLambert-St Louis
22h 03m
1 stop
PTY4:04 amPanama City Tocumen Intl
Aug 12
PTY3:30 pmPanama City Tocumen Intl
17h 07m
2 stops
STL8:37 amLambert-St Louis
$539

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 9/8

6:00 am-1:13 pm

1 stop7h 13m

Panama City Tocumen Intl

Tue 9/15

2:21 pm-11:37 pm

1 stop9h 16m

$525

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 9/8

6:14 am-2:14 pm

1 stop8h 00m

Panama City Tocumen Intl

Tue 9/15

3:30 pm-12:13 pm

2 stops20h 43m

$529

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 7/20

6:01 am-4:04 am

1 stop22h 03m

Panama City Tocumen Intl

Wed 7/29

9:45 am-11:44 pm

1 stop13h 59m

$534

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 7/6

6:01 am-4:04 am

1 stop22h 03m

Panama City Tocumen Intl

Wed 8/12

3:30 pm-8:37 am

2 stops17h 07m

$539

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 6/4

6:00 am-7:31 pm

1 stop13h 31m

Panama City Tocumen Intl

Sun 6/7

10:00 am-10:45 pm

1 stop12h 45m

$542

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 7/20

6:01 am-4:04 am

1 stop22h 03m

Panama City Tocumen Intl

Mon 7/27

10:55 pm-11:36 pm

1 stop24h 41m

$543

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 8/22

11:10 am-6:37 pm

1 stop7h 27m

Panama City Tocumen Intl

Wed 8/26

3:30 pm-8:37 am

2 stops17h 07m

$546

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 8/3

5:02 pm-12:14 pm

2 stops19h 12m

Panama City Tocumen Intl

Fri 8/7

1:24 pm-5:34 pm

2 stops28h 10m

$547

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 7/21

8:35 am-4:12 pm

1 stop7h 37m

Panama City Tocumen Intl

Tue 8/4

9:45 am-11:36 pm

1 stop13h 51m

$549

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 7/28

6:00 am-1:05 pm

1 stop7h 05m

Panama City Tocumen Intl

Fri 8/7

2:20 pm-9:20 am

1 stop19h 00m

$550

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Panama City?

What is the cheapest month to fly to Panama City?

In general, April is the cheapest month to fly from St. Louis to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $495. If you’re not able to fly to Panama City in April, then November is your next best option. Flight prices from St. Louis to Panama City during November average around $510.

How far in advance should I book a flight from St. Louis to Panama City?

You are more likely to see cheaper flights to Panama City from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $584 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from St. Louis for as low as $411 on momondo.

Can stopping save me money on St. Louis to Panama City flights?

You could potentially save up to 29% on your flight if you consider stops on a St. Louis to Panama City flight.

When to book flights from St. Louis to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City (STL to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City

Fastest flight time

6h 50m

Direct flights

None
The fastest flight from St. Louis to Panama City takes 6h 50m
There are no direct flights from St. Louis to Panama City. There are no popular flight routes from St. Louis to Panama City.
Search flight deals

Frequently asked questions about flying from St. Louis to Panama City

  • How far is Lambert-St Louis to Panama City Tocumen Intl by plane?

    There are 2151.1 mi between Lambert-St Louis and Panama City Tocumen Intl. Flights usually cover this in 6h 50m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Panama City?

Best airlines flying from St. Louis to Panama City

Compare and see reviews for airlines that fly from St. Louis to Panama City with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $373Free CancellationRating
7.1
11,668 reviews
Search American Airlines flights
United AirlinesPriceFrom $393Free CancellationRating
7.4
9,683 reviews
Search United Airlines flights
DeltaPriceFrom $393Free CancellationRating
7.9
8,459 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for St. Louis to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from St. Louis to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from St. Louis. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from St. Louis are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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