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Cheap flights from South Carolina to Panama City from $152

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 1:47 pmCHS-PTY
7h 47m1 stop
American Airlines Logo
2:50 pm - 12:46 amPTY-CHS
9h 56m1 stop
$370American Airlines
Find Deal
mié., dic. 3 - mié., dic. 10
American Airlines Logo
6:00 am - 1:47 pmCHS-PTY
7h 47m1 stop
American Airlines Logo
4:43 pm - 10:55 amPTY-CHS
18h 12m2 stops
$374American Airlines
Find Deal
mié., dic. 3 - mié., dic. 10
United Airlines Logo
10:59 am - 7:02 pmCHS-PTY
9h 03m1 stop
United Airlines Logo
7:55 am - 9:52 pmPTY-CHS
12h 57m1 stop
$390United Airlines
Find Deal
sáb., mar. 14 - mar., mar. 24
United Airlines Logo
6:40 am - 5:07 pmGSP-PTY
10h 27m1 stop
United Airlines Logo
11:35 am - 9:57 pmPTY-GSP
10h 22m1 stop
$392United Airlines
Find Deal
mié., ene. 21 - mié., feb. 4
Delta Logo
6:45 am - 12:55 pmGSP-PTY
7h 10m1 stop
Delta Logo
2:20 pm - 2:53 pmPTY-GSP
23h 33m1 stop
$398Delta
Find Deal
lun., may. 4 - mié., may. 6
Delta Logo
8:19 am - 7:59 pmCLT-PTY
11h 40m1 stop
Delta Logo
3:46 pm - 11:42 pmPTY-CLT
7h 56m1 stop
$400Delta
Find Deal
vie., dic. 5 - jue., dic. 11
Multiple Airlines Logo
7:59 pm - 8:06 amCLT-PTY
12h 07m1 stop
Multiple Airlines Logo
9:33 pm - 9:18 amPTY-CLT
11h 45m1 stop
$439Multiple Airlines
Find Deal
mar., nov. 18 - jue., nov. 20
Multiple Airlines Logo
7:59 pm - 8:06 amCLT-PTY
12h 07m1 stop
Multiple Airlines Logo
9:33 pm - 8:49 amPTY-CLT
11h 16m1 stop
$460Multiple Airlines
Find Deal
mar., nov. 18 - vie., nov. 21
WestJet Logo
5:36 pm - 9:20 amCAE-PTY
39h 44m2 stops
WestJet Logo
10:20 am - 10:16 amPTY-CAE
47h 56m2 stops
$2,300WestJet
Find Deal
dom., dic. 21 - dom., dic. 28
WestJet Logo
7:13 pm - 9:20 amSAV-PTY
38h 07m2 stops
WestJet Logo
10:20 am - 11:40 pmPTY-SAV
37h 20m2 stops
$2,515WestJet
Find Deal
dom., dic. 21 - dom., dic. 28

United Airlines flights from South Carolina to Panama City

Our best United Airlines deals on South Carolina to Panama City flight tickets
United Airlines
Mar 14
CHS10:59 amCharleston
9h 03m
1 stop
PTY7:02 pmPanama City Tocumen Intl
Mar 24
PTY7:55 amPanama City Tocumen Intl
12h 57m
1 stop
CHS9:52 pmCharleston
$390
Find similar
United Airlines
Jan 21
GSP6:40 amGreenville
10h 27m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Feb 4
PTY11:35 amPanama City Tocumen Intl
10h 22m
1 stop
GSP9:57 pmGreenville
$392
Find similar
United Airlines
Mar 14
CHS7:25 pmCharleston
9h 45m
1 stop
PTY4:10 amPanama City Tocumen Intl
Mar 17
PTY3:41 pmPanama City Tocumen Intl
23h 16m
1 stop
CHS3:57 pmCharleston
$398
Find similar

American Airlines flights from South Carolina to Panama City

Our best American Airlines deals on South Carolina to Panama City flight tickets
American Airlines
Dec 3
CHS6:00 amCharleston
7h 47m
1 stop
PTY1:47 pmPanama City Tocumen Intl
Dec 10
PTY2:50 pmPanama City Tocumen Intl
9h 56m
1 stop
CHS12:46 amCharleston
$370
Find similar
American Airlines
Dec 3
CHS6:00 amCharleston
7h 47m
1 stop
PTY1:47 pmPanama City Tocumen Intl
Dec 10
PTY4:43 pmPanama City Tocumen Intl
18h 12m
2 stops
CHS10:55 amCharleston
$374
Find similar
American Airlines
Dec 3
CHS5:38 pmCharleston
22h 04m
2 stops
PTY3:42 pmPanama City Tocumen Intl
Dec 10
PTY2:50 pmPanama City Tocumen Intl
19h 32m
2 stops
CHS10:22 amCharleston
$388
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated noviembre 6, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mié. 12/3

6:00 am-1:47 pm

1 stop7h 47m

Panama City Tocumen Intl

mié. 12/10

2:50 pm-12:46 am

1 stop9h 56m

$370

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mié. 12/3

6:00 am-1:47 pm

1 stop7h 47m

Panama City Tocumen Intl

mié. 12/10

4:43 pm-10:55 am

2 stops18h 12m

$374

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

sáb. 3/14

10:59 am-7:02 pm

1 stop9h 03m

Panama City Tocumen Intl

mar. 3/24

7:55 am-9:52 pm

1 stop12h 57m

$390

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 1/21

6:40 am-5:07 pm

1 stop10h 27m

Panama City Tocumen Intl

mié. 2/4

11:35 am-9:57 pm

1 stop10h 22m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

lun. 5/4

6:45 am-12:55 pm

1 stop7h 10m

Panama City Tocumen Intl

mié. 5/6

2:20 pm-2:53 pm

1 stop23h 33m

$398

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

vie. 12/5

8:19 am-7:59 pm

1 stop11h 40m

Panama City Tocumen Intl

jue. 12/11

3:46 pm-11:42 pm

1 stop7h 56m

$400

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

mar. 11/18

7:59 pm-8:06 am

1 stop12h 07m

Panama City Tocumen Intl

jue. 11/20

9:33 pm-9:18 am

1 stop11h 45m

$439

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

mar. 11/18

7:59 pm-8:06 am

1 stop12h 07m

Panama City Tocumen Intl

vie. 11/21

9:33 pm-8:49 am

1 stop11h 16m

$460

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

dom. 12/21

5:36 pm-9:20 am

2 stops39h 44m

Panama City Tocumen Intl

dom. 12/28

10:20 am-10:16 am

2 stops47h 56m

$2,300

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

dom. 12/21

7:13 pm-9:20 am

2 stops38h 07m

Panama City Tocumen Intl

dom. 12/28

10:20 am-11:40 pm

2 stops37h 20m

$2,515

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, September is the cheapest month to fly from South Carolina to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $389. If you’re not able to fly to Panama City in September, then November is your next best option. Flight prices from South Carolina to Panama City during November average around $430.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $341. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $712. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from South Carolina to Panama City during this time can be as low as $466. Try not to purchase tickets in the afternoon because they tend to be around $495. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on South Carolina to Panama City flights?

You could potentially save up to 17% on your flight if you consider stops on a South Carolina to Panama City flight.

Cheap South Carolina to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City

Direct flights

None
There are no direct flights from South Carolina to Panama City. There are no popular flight routes from South Carolina to Panama City.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Panama City Tocumen Intl Airport?

    Prices for flights from South Carolina to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from South Carolina to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Panama City

Compare and see reviews for airlines that fly from South Carolina to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $369Free CancellationRating
7.9
8,001 reviews
Search Delta flights
United AirlinesPriceFrom $383Free CancellationRating
7.4
9,007 reviews
Search United Airlines flights
American AirlinesPriceFrom $383Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

Finding the right flight to Panama City from South Carolina is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Panama City.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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