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Cheap flights from South Carolina to Panama City from $174

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 8/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

American Airlines Logo
6:00 am - 2:03 pmCHS-PTY
9h 03m1 stop
American Airlines Logo
2:43 pm - 12:23 amPTY-CHS
9h 40m1 stop
$369American Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6
American Airlines Logo
5:34 pm - 2:03 pmCHS-PTY
21h 29m2 stops
American Airlines Logo
2:43 pm - 12:23 amPTY-CHS
9h 40m1 stop
$374American Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6
American Airlines Logo
7:08 am - 2:31 pmCHS-PTY
8h 23m1 stop
American Airlines Logo
3:31 pm - 11:37 pmPTY-CHS
7h 06m1 stop
$389American Airlines
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Fri, Sep 19 - Mon, Sep 29
Delta Logo
6:45 am - 2:02 pmGSP-PTY
7h 17m1 stop
Delta Logo
3:27 pm - 11:36 pmPTY-GSP
8h 09m1 stop
$391Delta
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Wed, Jan 21 - Wed, Feb 4
American Airlines Logo
7:08 am - 2:31 pmCHS-PTY
8h 23m1 stop
American Airlines Logo
3:31 pm - 10:08 amPTY-CHS
17h 37m2 stops
$394American Airlines
Find Deal
Fri, Sep 19 - Mon, Sep 29
American Airlines Logo
6:24 pm - 3:35 pmGSP-PTY
21h 11m2 stops
American Airlines Logo
2:45 pm - 9:59 amPTY-GSP
19h 14m2 stops
$396American Airlines
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Wed, Jan 21 - Wed, Feb 4
Delta Logo
6:30 am - 8:04 pmCHS-PTY
13h 34m1 stop
Delta Logo
3:27 pm - 11:39 pmPTY-CHS
8h 12m1 stop
$409Delta
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Fri, Jan 16 - Sun, Feb 1
Logo
7:00 am - 12:45 amCLT-PTY
18h 45m2 stops
Logo
3:20 am - 10:59 pmPTY-CLT
18h 39m2 stops
$419
Find Deal
Fri, Aug 15 - Wed, Sep 24
Logo
5:45 am - 12:45 amCLT-PTY
20h 00m2 stops
Logo
3:25 am - 10:59 pmPTY-CLT
18h 34m2 stops
$421
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Wed, Sep 24 - Fri, Sep 26
United Airlines Logo
6:30 am - 2:45 pmCHS-PTY
8h 15m1 stop
United Airlines Logo
4:41 pm - 9:59 pmPTY-CHS
29h 18m1 stop
$557United Airlines
Find Deal
Sat, Nov 22 - Sat, Nov 29

Delta flights from South Carolina to Panama City

Our best Delta deals on South Carolina to Panama City flight tickets
Delta
Jan 21
GSP6:45 amGreenville
7h 17m
1 stop
PTY2:02 pmPanama City Tocumen Intl
Feb 4
PTY3:27 pmPanama City Tocumen Intl
8h 09m
1 stop
GSP11:36 pmGreenville
$391
Find similar
Delta
Jan 16
CHS6:30 amCharleston
13h 34m
1 stop
PTY8:04 pmPanama City Tocumen Intl
Feb 1
PTY3:27 pmPanama City Tocumen Intl
8h 12m
1 stop
CHS11:39 pmCharleston
$409
Find similar
Delta
Dec 5
GSP6:45 amGreenville
7h 07m
1 stop
PTY1:52 pmPanama City Tocumen Intl
Dec 13
PTY8:05 amPanama City Tocumen Intl
12h 11m
1 stop
GSP8:16 pmGreenville
$427
Find similar

United Airlines flights from South Carolina to Panama City

Our best United Airlines deals on South Carolina to Panama City flight tickets
United Airlines
Aug 13
GSP7:00 amGreenville
8h 14m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Aug 19
PTY3:30 pmPanama City Tocumen Intl
23h 16m
1 stop
GSP3:46 pmGreenville
$412
Find similar
United Airlines
Aug 13
GSP5:34 pmGreenville
26h 03m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Aug 19
PTY3:30 pmPanama City Tocumen Intl
29h 30m
1 stop
GSP10:00 pmGreenville
$420
Find similar
United Airlines
Aug 9
CHS7:00 amCharleston
8h 14m
1 stop
PTY2:14 pmPanama City Tocumen Intl
Aug 16
PTY3:30 pmPanama City Tocumen Intl
30h 15m
1 stop
CHS10:45 pmCharleston
$483
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momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 10/30

6:00 am-2:03 pm

1 stop9h 03m

Panama City Tocumen Intl

Thu 11/6

2:43 pm-12:23 am

1 stop9h 40m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 10/30

5:34 pm-2:03 pm

2 stops21h 29m

Panama City Tocumen Intl

Thu 11/6

2:43 pm-12:23 am

1 stop9h 40m

$374

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 9/19

7:08 am-2:31 pm

1 stop8h 23m

Panama City Tocumen Intl

Mon 9/29

3:31 pm-11:37 pm

1 stop7h 06m

$389

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:45 am-2:02 pm

1 stop7h 17m

Panama City Tocumen Intl

Wed 2/4

3:27 pm-11:36 pm

1 stop8h 09m

$391

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 9/19

7:08 am-2:31 pm

1 stop8h 23m

Panama City Tocumen Intl

Mon 9/29

3:31 pm-10:08 am

2 stops17h 37m

$394

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:24 pm-3:35 pm

2 stops21h 11m

Panama City Tocumen Intl

Wed 2/4

2:45 pm-9:59 am

2 stops19h 14m

$396

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/16

6:30 am-8:04 pm

1 stop13h 34m

Panama City Tocumen Intl

Sun 2/1

3:27 pm-11:39 pm

1 stop8h 12m

$409

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 8/15

7:00 am-12:45 am

2 stops18h 45m

Panama City Tocumen Intl

Wed 9/24

3:20 am-10:59 pm

2 stops18h 39m

$419

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 9/24

5:45 am-12:45 am

2 stops20h 00m

Panama City Tocumen Intl

Fri 9/26

3:25 am-10:59 pm

2 stops18h 34m

$421

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 11/22

6:30 am-2:45 pm

1 stop8h 15m

Panama City Tocumen Intl

Sat 11/29

4:41 pm-9:59 pm

1 stop29h 18m

$557

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, November is the cheapest month to fly from South Carolina to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $402. If you’re not able to fly to Panama City in November, then July is your next best option. Flight prices from South Carolina to Panama City during July average around $406.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $341. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $712. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from South Carolina to Panama City during this time can be as low as $466. Try not to purchase tickets in the afternoon because they tend to be around $495. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on South Carolina to Panama City flights?

You could potentially save up to 9% on your flight if you consider stops on a South Carolina to Panama City flight.

Cheap South Carolina to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City

Best Price Found

$174

Fastest flight time

6h 15m

Direct flights

None

Airports in Panama City

1 airport
The best one-way flight to Panama City from South Carolina in the past 72 hours is $174. The best round-trip flight deal from South Carolina to Panama City found on momondo in the last 72 hours is $369.
The fastest flight from South Carolina to Panama City takes 6h 15m
There are no direct flights from South Carolina to Panama City. Popular non-direct routes for this connection are Savannah/Hilton Head Airport - Panama City Tocumen Intl Airport, Charlotte Douglas Airport - Panama City Tocumen Intl Airport and Charleston Airport - Panama City Tocumen Intl Airport.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
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  • When did momondo last update prices for flights from South Carolina to Panama City Tocumen Intl Airport?

    Prices for flights from South Carolina to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from South Carolina to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Panama City

Compare and see reviews for airlines that fly from South Carolina to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $331Free CancellationRating
8.0
7,985 reviews
Search Delta flights
United AirlinesPriceFrom $352Free CancellationRating
7.4
8,916 reviews
Search United Airlines flights
American AirlinesPriceFrom $362Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

Finding the right flight to Panama City from South Carolina is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Panama City.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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