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Cheap flights from South Carolina to Panama City from $178

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 12/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Delta Logo
5:35 am - 1:56 pmCHS-PTY
8h 21m1 stop
Delta Logo
3:37 pm - 11:56 pmPTY-CHS
8h 19m1 stop
$369Delta
Find Deal
Tue, Nov 4 - Tue, Nov 11
American Airlines Logo
7:12 pm - 1:49 pmCHS-PTY
18h 37m2 stops
American Airlines Logo
2:49 pm - 12:23 pmPTY-CHS
21h 34m2 stops
$374American Airlines
Find Deal
Mon, Nov 3 - Fri, Nov 7
American Airlines Logo
7:57 pm - 1:49 pmCHS-PTY
17h 52m1 stop
American Airlines Logo
2:49 pm - 11:59 pmPTY-CHS
9h 10m1 stop
$377American Airlines
Find Deal
Mon, Nov 3 - Fri, Nov 7
Delta Logo
6:40 am - 1:56 pmCHS-PTY
7h 16m1 stop
Delta Logo
3:21 pm - 11:59 pmPTY-CHS
8h 38m1 stop
$389Delta
Find Deal
Mon, Nov 3 - Fri, Nov 7
American Airlines Logo
5:38 am - 1:10 pmGSP-PTY
7h 32m1 stop
American Airlines Logo
4:40 pm - 12:15 amPTY-GSP
7h 35m1 stop
$391American Airlines
Find Deal
Wed, Jan 21 - Wed, Feb 4
American Airlines Logo
6:34 pm - 12:10 pmCHS-PTY
18h 36m2 stops
American Airlines Logo
1:50 pm - 12:09 pmPTY-CHS
21h 19m2 stops
$394American Airlines
Find Deal
Sat, Mar 14 - Tue, Mar 24
American Airlines Logo
6:04 pm - 1:10 pmGSP-PTY
19h 06m2 stops
American Airlines Logo
4:40 pm - 12:06 pmPTY-GSP
19h 26m2 stops
$396American Airlines
Find Deal
Wed, Jan 21 - Wed, Feb 4
American Airlines Logo
8:08 pm - 3:35 pmCHS-PTY
19h 27m2 stops
American Airlines Logo
2:45 pm - 11:12 pmPTY-CHS
8h 27m1 stop
$399American Airlines
Find Deal
Mon, Jan 5 - Sun, Jan 25
United Airlines Logo
11:00 am - 8:02 pmCHS-PTY
9h 02m1 stop
United Airlines Logo
11:55 pm - 9:50 amPTY-CHS
9h 55m1 stop
$409United Airlines
Find Deal
Fri, Jan 16 - Sun, Feb 1
United Airlines Logo
6:30 am - 2:45 pmCHS-PTY
8h 15m1 stop
United Airlines Logo
4:41 pm - 9:57 pmPTY-CHS
29h 16m1 stop
$430United Airlines
Find Deal
Thu, Jan 8 - Sun, Jan 25

Delta flights from South Carolina to Panama City

Our best Delta deals on South Carolina to Panama City flight tickets
Delta
Nov 4
CHS5:35 amCharleston
8h 21m
1 stop
PTY1:56 pmPanama City Tocumen Intl
Nov 11
PTY3:37 pmPanama City Tocumen Intl
8h 19m
1 stop
CHS11:56 pmCharleston
$369
Find similar
Delta
Nov 3
CHS6:40 amCharleston
7h 16m
1 stop
PTY1:56 pmPanama City Tocumen Intl
Nov 7
PTY3:21 pmPanama City Tocumen Intl
8h 38m
1 stop
CHS11:59 pmCharleston
$389
Find similar
Delta
Jan 1
CLT6:00 amCharlotte Douglas
7h 55m
1 stop
PTY1:55 pmPanama City Tocumen Intl
Jan 22
PTY3:27 pmPanama City Tocumen Intl
17h 13m
1 stop
CLT8:40 amCharlotte Douglas
$405
Find similar

American Airlines flights from South Carolina to Panama City

Our best American Airlines deals on South Carolina to Panama City flight tickets
American Airlines
Nov 3
CHS7:12 pmCharleston
18h 37m
2 stops
PTY1:49 pmPanama City Tocumen Intl
Nov 7
PTY2:49 pmPanama City Tocumen Intl
21h 34m
2 stops
CHS12:23 pmCharleston
$374
Find similar
American Airlines
Nov 3
CHS7:57 pmCharleston
17h 52m
1 stop
PTY1:49 pmPanama City Tocumen Intl
Nov 7
PTY2:49 pmPanama City Tocumen Intl
9h 10m
1 stop
CHS11:59 pmCharleston
$377
Find similar
American Airlines
Jan 21
GSP5:38 amGreenville
7h 32m
1 stop
PTY1:10 pmPanama City Tocumen Intl
Feb 4
PTY4:40 pmPanama City Tocumen Intl
7h 35m
1 stop
GSP12:15 amGreenville
$391
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 22, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 11/4

5:35 am-1:56 pm

1 stop8h 21m

Panama City Tocumen Intl

Tue 11/11

3:37 pm-11:56 pm

1 stop8h 19m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 11/3

7:12 pm-1:49 pm

2 stops18h 37m

Panama City Tocumen Intl

Fri 11/7

2:49 pm-12:23 pm

2 stops21h 34m

$374

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 11/3

7:57 pm-1:49 pm

1 stop17h 52m

Panama City Tocumen Intl

Fri 11/7

2:49 pm-11:59 pm

1 stop9h 10m

$377

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 11/3

6:40 am-1:56 pm

1 stop7h 16m

Panama City Tocumen Intl

Fri 11/7

3:21 pm-11:59 pm

1 stop8h 38m

$389

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

5:38 am-1:10 pm

1 stop7h 32m

Panama City Tocumen Intl

Wed 2/4

4:40 pm-12:15 am

1 stop7h 35m

$391

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 3/14

6:34 pm-12:10 pm

2 stops18h 36m

Panama City Tocumen Intl

Tue 3/24

1:50 pm-12:09 pm

2 stops21h 19m

$394

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:04 pm-1:10 pm

2 stops19h 06m

Panama City Tocumen Intl

Wed 2/4

4:40 pm-12:06 pm

2 stops19h 26m

$396

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 1/5

8:08 pm-3:35 pm

2 stops19h 27m

Panama City Tocumen Intl

Sun 1/25

2:45 pm-11:12 pm

1 stop8h 27m

$399

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/16

11:00 am-8:02 pm

1 stop9h 02m

Panama City Tocumen Intl

Sun 2/1

11:55 pm-9:50 am

1 stop9h 55m

$409

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 1/8

6:30 am-2:45 pm

1 stop8h 15m

Panama City Tocumen Intl

Sun 1/25

4:41 pm-9:57 pm

1 stop29h 16m

$430

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, November is the cheapest month to fly from South Carolina to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $424. If you’re not able to fly to Panama City in November, then September is your next best option. Flight prices from South Carolina to Panama City during September average around $444.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $341. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $712. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from South Carolina to Panama City during this time can be as low as $466. Try not to purchase tickets in the afternoon because they tend to be around $495. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on South Carolina to Panama City flights?

You could potentially save up to 9% on your flight if you consider stops on a South Carolina to Panama City flight.

Cheap South Carolina to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City

Direct flights

None
There are no direct flights from South Carolina to Panama City. There are no popular flight routes from South Carolina to Panama City.
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  • When did momondo last update prices for flights from South Carolina to Panama City Tocumen Intl Airport?

    Prices for flights from South Carolina to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from South Carolina to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Panama City

Compare and see reviews for airlines that fly from South Carolina to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $352Free CancellationRating
7.4
8,922 reviews
Search United Airlines flights
American AirlinesPriceFrom $361Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $369Free CancellationRating
7.9
7,971 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

Finding the right flight to Panama City from South Carolina is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Panama City.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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