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Cheap flights from South Carolina to Panama City from $237

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 11/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:48 pm - 8:06 am
CLT
-
PTY
14h 18m
1 stop
Multiple Airlines Logo
5:30 am - 4:46 pm
PTY
-
CLT
10h 16m
2 stops
$517Multiple Airlines
Fri, Aug 14 - Thu, Aug 20
Multiple Airlines Logo
1:58 pm - 8:37 pm
CLT
-
PTY
7h 39m
1 stop
Multiple Airlines Logo
5:30 am - 4:05 pm
PTY
-
CLT
9h 35m
2 stops
$518Multiple Airlines
Sun, Sep 6 - Thu, Sep 10
Multiple Airlines Logo
1:58 pm - 8:37 pm
CLT
-
PTY
7h 39m
1 stop
Multiple Airlines Logo
3:10 pm - 4:05 pm
PTY
-
CLT
23h 55m
2 stops
$525Multiple Airlines
Mon, Sep 7 - Wed, Sep 9
Copa Airlines Logo
6:00 am - 1:31 pm
CLT
-
PTY
7h 31m
1 stop
Copa Airlines Logo
6:46 pm - 10:04 am
PTY
-
CLT
15h 18m
1 stop
$533Copa Airlines
Thu, Nov 5 - Wed, Nov 11
United Airlines Logo
11:05 am - 7:31 pm
CHS
-
PTY
9h 26m
1 stop
United Airlines Logo
10:00 am - 10:21 pm
PTY
-
CHS
11h 21m
1 stop
$537United Airlines
Thu, Oct 1 - Wed, Oct 7
United Airlines Logo
6:53 am - 8:02 pm
CLT
-
PTY
13h 09m
1 stop
United Airlines Logo
4:41 pm - 10:52 am
PTY
-
CLT
18h 11m
1 stop
$539United Airlines
Wed, Nov 4 - Tue, Nov 10
Delta Logo
5:30 pm - 12:55 pm
CLT
-
PTY
20h 25m
1 stop
Delta Logo
2:23 pm - 11:59 pm
PTY
-
CLT
8h 36m
1 stop
$546Delta
Sun, Sep 6 - Thu, Sep 10
American Airlines Logo
6:00 am - 12:16 pm
CHS
-
PTY
7h 16m
1 stop
American Airlines Logo
1:16 pm - 9:36 pm
PTY
-
CHS
7h 20m
1 stop
$557American Airlines
Fri, Sep 11 - Tue, Sep 15
American Airlines Logo
7:00 am - 12:24 pm
GSP
-
PTY
6h 24m
1 stop
American Airlines Logo
3:35 pm - 11:14 pm
PTY
-
GSP
6h 39m
1 stop
$583American Airlines
Tue, Sep 15 - Thu, Oct 15
Delta Logo
5:35 am - 12:55 pm
SAV
-
PTY
8h 20m
1 stop
Delta Logo
2:20 pm - 9:16 am
PTY
-
SAV
17h 56m
1 stop
$589Delta
Thu, Aug 20 - Thu, Aug 27

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Delta flights from South Carolina to Panama City

Our best Delta deals on South Carolina to Panama City flight tickets
Delta
Sep 6
CLT5:30 pmCharlotte Douglas
20h 25m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Sep 10
PTY2:23 pmPanama City Tocumen Intl
8h 36m
1 stop
CLT11:59 pmCharlotte Douglas
$546
Delta
Sep 23
GSP7:00 amGreenville
6h 58m
1 stop
PTY12:58 pmPanama City Tocumen Intl
Sep 30
PTY2:23 pmPanama City Tocumen Intl
7h 37m
1 stop
GSP11:00 pmGreenville
$567
Delta
Sep 6
CLT5:30 pmCharlotte Douglas
20h 25m
1 stop
PTY12:55 pmPanama City Tocumen Intl
Sep 11
PTY2:23 pmPanama City Tocumen Intl
8h 36m
1 stop
CLT11:59 pmCharlotte Douglas
$576

American Airlines flights from South Carolina to Panama City

Our best American Airlines deals on South Carolina to Panama City flight tickets
American Airlines
Oct 2
CLT7:07 amCharlotte Douglas
6h 09m
1 stop
PTY12:16 pmPanama City Tocumen Intl
Oct 9
PTY3:35 pmPanama City Tocumen Intl
18h 01m
1 stop
CLT10:36 amCharlotte Douglas
$550
American Airlines
Sep 11
CHS6:00 amCharleston
7h 16m
1 stop
PTY12:16 pmPanama City Tocumen Intl
Sep 15
PTY1:16 pmPanama City Tocumen Intl
7h 20m
1 stop
CHS9:36 pmCharleston
$557
American Airlines
Sep 6
CLT7:05 amCharlotte Douglas
6h 34m
1 stop
PTY12:39 pmPanama City Tocumen Intl
Sep 18
PTY1:16 pmPanama City Tocumen Intl
9h 38m
1 stop
CLT11:54 pmCharlotte Douglas
$569

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 28, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 8/14

6:48 pm-8:06 am

1 stop14h 18m

Panama City Tocumen Intl

Thu 8/20

5:30 am-4:46 pm

2 stops10h 16m

$517

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 9/6

1:58 pm-8:37 pm

1 stop7h 39m

Panama City Tocumen Intl

Thu 9/10

5:30 am-4:05 pm

2 stops9h 35m

$518

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 9/7

1:58 pm-8:37 pm

1 stop7h 39m

Panama City Tocumen Intl

Wed 9/9

3:10 pm-4:05 pm

2 stops23h 55m

$525

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 11/5

6:00 am-1:31 pm

1 stop7h 31m

Panama City Tocumen Intl

Wed 11/11

6:46 pm-10:04 am

1 stop15h 18m

$533

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 10/1

11:05 am-7:31 pm

1 stop9h 26m

Panama City Tocumen Intl

Wed 10/7

10:00 am-10:21 pm

1 stop11h 21m

$537

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 11/4

6:53 am-8:02 pm

1 stop13h 09m

Panama City Tocumen Intl

Tue 11/10

4:41 pm-10:52 am

1 stop18h 11m

$539

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 9/6

5:30 pm-12:55 pm

1 stop20h 25m

Panama City Tocumen Intl

Thu 9/10

2:23 pm-11:59 pm

1 stop8h 36m

$546

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 9/11

6:00 am-12:16 pm

1 stop7h 16m

Panama City Tocumen Intl

Tue 9/15

1:16 pm-9:36 pm

1 stop7h 20m

$557
Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

7:00 am-12:24 pm

1 stop6h 24m

Panama City Tocumen Intl

Thu 10/15

3:35 pm-11:14 pm

1 stop6h 39m

$583

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

Thu 8/20

5:35 am-12:55 pm

1 stop8h 20m

Panama City Tocumen Intl

Thu 8/27

2:20 pm-9:16 am

1 stop17h 56m

$589

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, September is the cheapest month to fly from South Carolina to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $235. If you’re not able to fly to Panama City in September, then October is your next best option. Flight prices from South Carolina to Panama City during October average around $309.

Can stopping save me money on South Carolina to Panama City flights?

You could potentially save up to 32% on your flight if you consider stops on a South Carolina to Panama City flight.

Cheap South Carolina to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City

Fastest flight time

7h 31m

Direct flights

None
The fastest flight from South Carolina to Panama City takes 7h 31m
There are no direct flights from South Carolina to Panama City. There are no popular flight routes from South Carolina to Panama City.
Search flight deals

Frequently asked questions about flying from South Carolina to Panama City

  • When did momondo last update prices for flights from South Carolina to Panama City Tocumen Intl Airport?

    Prices for flights from South Carolina to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from South Carolina to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Panama City

Compare and see reviews for airlines that fly from South Carolina to Panama City with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $235Free CancellationRating
7.4
9,899 reviews
Search United Airlines flights
DeltaPriceFrom $369Free CancellationRating
7.8
8,455 reviews
Search Delta flights
American AirlinesPriceFrom $399Free CancellationRating
7.1
11,776 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

Finding the right flight to Panama City from South Carolina is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Panama City.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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