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Cheap flights from South Carolina to Panama City from $170

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 4/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:30 am - 12:35 am
CLT
-
PTY
19h 05m
2 stops
Multiple Airlines Logo
3:10 pm - 11:45 am
PTY
-
CLT
19h 35m
2 stops
$394Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
6:30 am - 12:35 am
CLT
-
PTY
19h 05m
2 stops
Multiple Airlines Logo
5:55 pm - 11:45 am
PTY
-
CLT
16h 50m
2 stops
$418Multiple Airlines
Thu, Apr 30 - Sat, May 2
Multiple Airlines Logo
6:30 am - 3:54 pm
CLT
-
PTY
10h 24m
1 stop
Multiple Airlines Logo
9:33 pm - 11:45 am
PTY
-
CLT
13h 12m
1 stop
$432Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
American Airlines Logo
5:17 am - 2:20 pm
CLT
-
PTY
10h 03m
1 stop
American Airlines Logo
3:20 pm - 8:25 am
PTY
-
CLT
16h 05m
1 stop
$449American Airlines
Wed, Aug 12 - Wed, Aug 19
American Airlines Logo
5:17 am - 2:20 pm
CLT
-
PTY
10h 03m
1 stop
American Airlines Logo
3:20 pm - 6:29 am
PTY
-
CLT
14h 09m
2 stops
$453American Airlines
Wed, Aug 12 - Wed, Aug 19
United Airlines Logo
6:50 am - 6:37 pm
CHS
-
PTY
12h 47m
1 stop
United Airlines Logo
10:00 am - 10:15 pm
PTY
-
CHS
11h 15m
1 stop
$467United Airlines
Thu, Jun 18 - Wed, Jul 1
United Airlines Logo
6:50 am - 6:37 pm
CHS
-
PTY
12h 47m
1 stop
United Airlines Logo
10:55 pm - 9:48 pm
PTY
-
CHS
21h 53m
2 stops
$471United Airlines
Thu, Jun 18 - Wed, Jul 1
Copa Airlines Logo
6:15 am - 7:31 pm
SAV
-
PTY
14h 16m
1 stop
Copa Airlines Logo
10:00 am - 9:55 pm
PTY
-
SAV
10h 55m
1 stop
$539Copa Airlines
Thu, Jun 18 - Tue, Jun 30
Delta Logo
6:50 am - 1:02 pm
CAE
-
PTY
7h 12m
1 stop
Delta Logo
2:15 pm - 11:49 pm
PTY
-
CAE
8h 34m
1 stop
$617Delta
Sat, May 2 - Thu, May 21
Delta Logo
5:42 am - 12:50 pm
AGS
-
PTY
8h 08m
1 stop
Delta Logo
2:15 pm - 11:52 pm
PTY
-
AGS
8h 37m
1 stop
$1,310Delta
Mon, May 11 - Mon, May 18

United Airlines flights from South Carolina to Panama City

Our best United Airlines deals on South Carolina to Panama City flight tickets
United Airlines
Jun 18
CHS6:50 amCharleston
12h 47m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Jul 1
PTY10:00 amPanama City Tocumen Intl
11h 15m
1 stop
CHS10:15 pmCharleston
$467
United Airlines
Jun 18
CHS6:50 amCharleston
12h 47m
1 stop
PTY6:37 pmPanama City Tocumen Intl
Jun 30
PTY10:55 pmPanama City Tocumen Intl
21h 53m
2 stops
CHS9:48 pmCharleston
$471
United Airlines
May 11
CHS5:08 pmCharleston
24h 04m
2 stops
PTY4:12 pmPanama City Tocumen Intl
May 20
PTY7:55 amPanama City Tocumen Intl
15h 04m
2 stops
CHS11:59 pmCharleston
$478

Delta flights from South Carolina to Panama City

Our best Delta deals on South Carolina to Panama City flight tickets
Delta
Apr 13
CLT5:30 amCharlotte Douglas
8h 32m
1 stop
PTY1:02 pmPanama City Tocumen Intl
Apr 27
PTY2:27 pmPanama City Tocumen Intl
8h 26m
1 stop
CLT11:53 pmCharlotte Douglas
$499
Delta
Apr 13
CLT5:30 amCharlotte Douglas
8h 32m
1 stop
PTY1:02 pmPanama City Tocumen Intl
Apr 27
PTY2:27 pmPanama City Tocumen Intl
8h 26m
1 stop
CLT11:53 pmCharlotte Douglas
$519
Delta
Mar 30
CLT7:34 amCharlotte Douglas
6h 29m
1 stop
PTY1:03 pmPanama City Tocumen Intl
Apr 5
PTY2:28 pmPanama City Tocumen Intl
17h 12m
1 stop
CLT8:40 amCharlotte Douglas
$579

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 29, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 4/23

6:30 am-12:35 am

2 stops19h 05m

Panama City Tocumen Intl

Sun 4/26

3:10 pm-11:45 am

2 stops19h 35m

$394

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 4/30

6:30 am-12:35 am

2 stops19h 05m

Panama City Tocumen Intl

Sat 5/2

5:55 pm-11:45 am

2 stops16h 50m

$418

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 4/23

6:30 am-3:54 pm

1 stop10h 24m

Panama City Tocumen Intl

Sun 4/26

9:33 pm-11:45 am

1 stop13h 12m

$432

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 8/12

5:17 am-2:20 pm

1 stop10h 03m

Panama City Tocumen Intl

Wed 8/19

3:20 pm-8:25 am

1 stop16h 05m

$449

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 8/12

5:17 am-2:20 pm

1 stop10h 03m

Panama City Tocumen Intl

Wed 8/19

3:20 pm-6:29 am

2 stops14h 09m

$453

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 6/18

6:50 am-6:37 pm

1 stop12h 47m

Panama City Tocumen Intl

Wed 7/1

10:00 am-10:15 pm

1 stop11h 15m

$467

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 6/18

6:50 am-6:37 pm

1 stop12h 47m

Panama City Tocumen Intl

Wed 7/1

10:55 pm-9:48 pm

2 stops21h 53m

$471

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

Thu 6/18

6:15 am-7:31 pm

1 stop14h 16m

Panama City Tocumen Intl

Tue 6/30

10:00 am-9:55 pm

1 stop10h 55m

$539
Quickest round-trip

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

Sat 5/2

6:50 am-1:02 pm

1 stop7h 12m

Panama City Tocumen Intl

Thu 5/21

2:15 pm-11:49 pm

1 stop8h 34m

$617

AugustaPanama City

AGS - PTY

AGSPTY

Augusta Bush Field

Mon 5/11

5:42 am-12:50 pm

1 stop8h 08m

Panama City Tocumen Intl

Mon 5/18

2:15 pm-11:52 pm

1 stop8h 37m

$1,310

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, September is the cheapest month to fly from South Carolina to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $389. If you’re not able to fly to Panama City in September, then May is your next best option. Flight prices from South Carolina to Panama City during May average around $440.

Can stopping save me money on South Carolina to Panama City flights?

You could potentially save up to 32% on your flight if you consider stops on a South Carolina to Panama City flight.

Cheap South Carolina to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City

Fastest flight time

6h 13m

Direct flights

None
The fastest flight from South Carolina to Panama City takes 6h 13m
There are no direct flights from South Carolina to Panama City. There are no popular flight routes from South Carolina to Panama City.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Panama City Tocumen Intl Airport?

    Prices for flights from South Carolina to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from South Carolina to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Panama City

Compare and see reviews for airlines that fly from South Carolina to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $309Free CancellationRating
7.9
8,359 reviews
Search Delta flights
American AirlinesPriceFrom $363Free CancellationRating
7.1
11,521 reviews
Search American Airlines flights
United AirlinesPriceFrom $369Free CancellationRating
7.4
9,509 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

Finding the right flight to Panama City from South Carolina is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Panama City.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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