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Cheap flights from South Carolina to Panama City from $201

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 10/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:00 am - 2:14 pm
CHS
-
PTY
8h 14m
1 stop
United Airlines Logo
10:00 am - 10:13 pm
PTY
-
CHS
11h 13m
1 stop
$467United Airlines
Tue, Sep 8 - Thu, Sep 17
United Airlines Logo
10:00 am - 4:04 am
CHS
-
PTY
19h 04m
2 stops
United Airlines Logo
3:30 pm - 1:55 pm
PTY
-
CHS
21h 25m
2 stops
$471United Airlines
Thu, Aug 27 - Mon, Aug 31
United Airlines Logo
4:02 pm - 4:04 am
CHS
-
PTY
13h 02m
1 stop
United Airlines Logo
3:30 pm - 10:13 pm
PTY
-
CHS
29h 43m
1 stop
$476United Airlines
Thu, Aug 27 - Mon, Aug 31
United Airlines Logo
11:20 am - 4:04 am
CLT
-
PTY
17h 44m
1 stop
United Airlines Logo
10:55 pm - 5:14 pm
PTY
-
CLT
17h 19m
1 stop
$479United Airlines
Wed, Aug 5 - Mon, Aug 10
American Airlines Logo
6:00 am - 12:24 pm
CHS
-
PTY
7h 24m
1 stop
American Airlines Logo
1:24 pm - 12:06 am
PTY
-
CHS
9h 42m
1 stop
$497American Airlines
Fri, Aug 14 - Fri, Aug 21
Delta Logo
6:45 am - 12:55 pm
CLT
-
PTY
7h 10m
1 stop
Delta Logo
2:30 pm - 8:52 am
PTY
-
CLT
17h 22m
1 stop
$509Delta
Wed, Aug 5 - Sat, Aug 8
Delta Logo
6:59 am - 1:09 pm
CLT
-
PTY
7h 10m
1 stop
Delta Logo
2:24 pm - 4:18 pm
PTY
-
CLT
24h 54m
1 stop
$515Delta
Sun, Jun 28 - Thu, Jul 2
American Airlines Logo
5:55 am - 2:10 pm
GSP
-
PTY
9h 15m
1 stop
American Airlines Logo
3:35 pm - 11:14 pm
PTY
-
GSP
6h 39m
1 stop
$523American Airlines
Tue, Sep 15 - Thu, Oct 15
Multiple Airlines Logo
7:15 pm - 10:30 am
SAV
-
PTY
16h 15m
2 stops
Multiple Airlines Logo
3:50 pm - 6:20 pm
PTY
-
SAV
25h 30m
2 stops
$570Multiple Airlines
Sat, May 23 - Thu, May 28
Multiple Airlines Logo
10:42 am - 10:30 am
SAV
-
PTY
24h 48m
2 stops
Multiple Airlines Logo
3:50 pm - 9:52 am
PTY
-
SAV
17h 02m
2 stops
$578Multiple Airlines
Fri, May 29 - Mon, Jun 1

American Airlines flights from South Carolina to Panama City

Our best American Airlines deals on South Carolina to Panama City flight tickets
American Airlines
Aug 14
CHS6:00 amCharleston
7h 24m
1 stop
PTY12:24 pmPanama City Tocumen Intl
Aug 21
PTY1:24 pmPanama City Tocumen Intl
9h 42m
1 stop
CHS12:06 amCharleston
$497
American Airlines
Sep 6
CLT5:20 amCharlotte Douglas
8h 04m
1 stop
PTY12:24 pmPanama City Tocumen Intl
Sep 18
PTY3:40 pmPanama City Tocumen Intl
14h 28m
1 stop
CLT7:08 amCharlotte Douglas
$509
American Airlines
Sep 15
GSP5:55 amGreenville
9h 15m
1 stop
PTY2:10 pmPanama City Tocumen Intl
Oct 15
PTY3:35 pmPanama City Tocumen Intl
6h 39m
1 stop
GSP11:14 pmGreenville
$523

Delta flights from South Carolina to Panama City

Our best Delta deals on South Carolina to Panama City flight tickets
Delta
Sep 2
CLT6:45 amCharlotte Douglas
7h 28m
1 stop
PTY1:13 pmPanama City Tocumen Intl
Sep 30
PTY2:21 pmPanama City Tocumen Intl
17h 17m
1 stop
CLT8:38 amCharlotte Douglas
$464
Delta
Jun 28
CLT6:59 amCharlotte Douglas
7h 10m
1 stop
PTY1:09 pmPanama City Tocumen Intl
Jul 2
PTY2:24 pmPanama City Tocumen Intl
24h 54m
1 stop
CLT4:18 pmCharlotte Douglas
$515
Delta
Jun 22
CLT6:59 amCharlotte Douglas
7h 10m
1 stop
PTY1:09 pmPanama City Tocumen Intl
Jul 2
PTY2:24 pmPanama City Tocumen Intl
24h 54m
1 stop
CLT4:18 pmCharlotte Douglas
$520

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 9/8

7:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Thu 9/17

10:00 am-10:13 pm

1 stop11h 13m

$467

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 8/27

10:00 am-4:04 am

2 stops19h 04m

Panama City Tocumen Intl

Mon 8/31

3:30 pm-1:55 pm

2 stops21h 25m

$471

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 8/27

4:02 pm-4:04 am

1 stop13h 02m

Panama City Tocumen Intl

Mon 8/31

3:30 pm-10:13 pm

1 stop29h 43m

$476

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 8/5

11:20 am-4:04 am

1 stop17h 44m

Panama City Tocumen Intl

Mon 8/10

10:55 pm-5:14 pm

1 stop17h 19m

$479

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 8/14

6:00 am-12:24 pm

1 stop7h 24m

Panama City Tocumen Intl

Fri 8/21

1:24 pm-12:06 am

1 stop9h 42m

$497

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 8/5

6:45 am-12:55 pm

1 stop7h 10m

Panama City Tocumen Intl

Sat 8/8

2:30 pm-8:52 am

1 stop17h 22m

$509

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Sun 6/28

6:59 am-1:09 pm

1 stop7h 10m

Panama City Tocumen Intl

Thu 7/2

2:24 pm-4:18 pm

1 stop24h 54m

$515
Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

5:55 am-2:10 pm

1 stop9h 15m

Panama City Tocumen Intl

Thu 10/15

3:35 pm-11:14 pm

1 stop6h 39m

$523

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

Sat 5/23

7:15 pm-10:30 am

2 stops16h 15m

Panama City Tocumen Intl

Thu 5/28

3:50 pm-6:20 pm

2 stops25h 30m

$570

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

Fri 5/29

10:42 am-10:30 am

2 stops24h 48m

Panama City Tocumen Intl

Mon 6/1

3:50 pm-9:52 am

2 stops17h 02m

$578

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, July is the cheapest month to fly from South Carolina to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $172. If you’re not able to fly to Panama City in July, then August is your next best option. Flight prices from South Carolina to Panama City during August average around $183.

Can stopping save me money on South Carolina to Panama City flights?

You could potentially save up to 32% on your flight if you consider stops on a South Carolina to Panama City flight.

Cheap South Carolina to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City

Fastest flight time

7h 10m

Direct flights

None
The fastest flight from South Carolina to Panama City takes 7h 10m
There are no direct flights from South Carolina to Panama City. There are no popular flight routes from South Carolina to Panama City.
Search flight deals

Frequently asked questions about flying from South Carolina to Panama City

  • When did momondo last update prices for flights from South Carolina to Panama City Tocumen Intl Airport?

    Prices for flights from South Carolina to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from South Carolina to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Panama City

Compare and see reviews for airlines that fly from South Carolina to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $309Free CancellationRating
7.9
8,451 reviews
Search Delta flights
United AirlinesPriceFrom $369Free CancellationRating
7.4
9,699 reviews
Search United Airlines flights
American AirlinesPriceFrom $373Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

Finding the right flight to Panama City from South Carolina is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Panama City.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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