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Cheap flights from South Carolina to Panama City from $158

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 3/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:40 pm - 4:04 am
CHS
-
PTY
9h 24m
1 stop
United Airlines Logo
7:55 am - 9:59 pm
PTY
-
CHS
13h 04m
1 stop
$391United Airlines
Thu, Apr 16 - Mon, Apr 20
American Airlines Logo
6:00 am - 12:40 pm
CHS
-
PTY
7h 40m
1 stop
American Airlines Logo
1:40 pm - 12:42 pm
PTY
-
CHS
22h 02m
2 stops
$395American Airlines
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
6:00 am - 2:20 pm
CHS
-
PTY
9h 20m
1 stop
American Airlines Logo
3:51 pm - 11:59 pm
PTY
-
CHS
7h 08m
1 stop
$409American Airlines
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
8:45 pm - 12:46 pm
CLT
-
PTY
17h 01m
1 stop
American Airlines Logo
1:10 pm - 9:23 pm
PTY
-
CLT
7h 13m
1 stop
$409American Airlines
Thu, May 14 - Thu, May 28
Multiple Airlines Logo
7:00 am - 1:00 am
CLT
-
PTY
19h 00m
2 stops
Multiple Airlines Logo
5:50 pm - 12:07 pm
PTY
-
CLT
17h 17m
2 stops
$423Multiple Airlines
Tue, Mar 10 - Tue, Mar 17
Azul Logo
6:12 am - 8:02 pm
GSP
-
PTY
13h 50m
1 stop
Azul Logo
9:30 am - 11:59 pm
PTY
-
GSP
13h 29m
1 stop
$429Azul
Wed, Feb 25 - Wed, Mar 11
Multiple Airlines Logo
7:00 am - 1:00 am
CLT
-
PTY
19h 00m
2 stops
Multiple Airlines Logo
5:50 pm - 12:07 pm
PTY
-
CLT
17h 17m
2 stops
$448Multiple Airlines
Tue, Mar 10 - Tue, Mar 17
Copa Airlines Logo
12:07 pm - 7:31 pm
GSP
-
PTY
8h 24m
1 stop
Copa Airlines Logo
7:55 am - 10:14 pm
PTY
-
GSP
13h 19m
1 stop
$459Copa Airlines
Sat, May 2 - Sat, May 9
LATAM Airlines Logo
6:50 am - 1:03 pm
CAE
-
PTY
7h 13m
1 stop
LATAM Airlines Logo
2:27 pm - 11:29 am
PTY
-
CAE
20h 02m
1 stop
$463LATAM Airlines
Tue, Mar 31 - Thu, Apr 16
LATAM Airlines Logo
6:50 am - 1:03 pm
CAE
-
PTY
7h 13m
1 stop
LATAM Airlines Logo
2:27 pm - 11:29 am
PTY
-
CAE
20h 02m
1 stop
$483LATAM Airlines
Tue, Mar 31 - Fri, Apr 17

United Airlines flights from South Carolina to Panama City

Our best United Airlines deals on South Carolina to Panama City flight tickets
United Airlines
Apr 16
CHS7:40 pmCharleston
9h 24m
1 stop
PTY4:04 amPanama City Tocumen Intl
Apr 20
PTY7:55 amPanama City Tocumen Intl
13h 04m
1 stop
CHS9:59 pmCharleston
$391
United Airlines
Apr 16
CHS7:40 pmCharleston
9h 24m
1 stop
PTY4:04 amPanama City Tocumen Intl
Apr 19
PTY7:55 amPanama City Tocumen Intl
13h 04m
1 stop
CHS9:59 pmCharleston
$411
United Airlines
Jun 6
CHS11:03 amCharleston
9h 28m
1 stop
PTY7:31 pmPanama City Tocumen Intl
Jun 14
PTY7:55 amPanama City Tocumen Intl
13h 17m
1 stop
CHS10:12 pmCharleston
$431

American Airlines flights from South Carolina to Panama City

Our best American Airlines deals on South Carolina to Panama City flight tickets
American Airlines
Mar 24
CHS6:00 amCharleston
7h 40m
1 stop
PTY12:40 pmPanama City Tocumen Intl
Mar 31
PTY1:40 pmPanama City Tocumen Intl
22h 02m
2 stops
CHS12:42 pmCharleston
$395
American Airlines
Mar 24
CHS6:00 amCharleston
9h 20m
1 stop
PTY2:20 pmPanama City Tocumen Intl
Mar 31
PTY3:51 pmPanama City Tocumen Intl
7h 08m
1 stop
CHS11:59 pmCharleston
$409
American Airlines
May 11
CLT8:45 pmCharlotte Douglas
17h 01m
1 stop
PTY12:46 pmPanama City Tocumen Intl
May 19
PTY1:49 pmPanama City Tocumen Intl
15h 37m
2 stops
CLT6:26 amCharlotte Douglas
$413

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 10, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 4/16

7:40 pm-4:04 am

1 stop9h 24m

Panama City Tocumen Intl

Mon 4/20

7:55 am-9:59 pm

1 stop13h 04m

$391

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 3/24

6:00 am-12:40 pm

1 stop7h 40m

Panama City Tocumen Intl

Tue 3/31

1:40 pm-12:42 pm

2 stops22h 02m

$395

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 3/24

6:00 am-2:20 pm

1 stop9h 20m

Panama City Tocumen Intl

Tue 3/31

3:51 pm-11:59 pm

1 stop7h 08m

$409

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 5/14

8:45 pm-12:46 pm

1 stop17h 01m

Panama City Tocumen Intl

Thu 5/28

1:10 pm-9:23 pm

1 stop7h 13m

$409

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 3/10

7:00 am-1:00 am

2 stops19h 00m

Panama City Tocumen Intl

Tue 3/17

5:50 pm-12:07 pm

2 stops17h 17m

$423

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 2/25

6:12 am-8:02 pm

1 stop13h 50m

Panama City Tocumen Intl

Wed 3/11

9:30 am-11:59 pm

1 stop13h 29m

$429

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Tue 3/10

7:00 am-1:00 am

2 stops19h 00m

Panama City Tocumen Intl

Tue 3/17

5:50 pm-12:07 pm

2 stops17h 17m

$448

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sat 5/2

12:07 pm-7:31 pm

1 stop8h 24m

Panama City Tocumen Intl

Sat 5/9

7:55 am-10:14 pm

1 stop13h 19m

$459

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

Tue 3/31

6:50 am-1:03 pm

1 stop7h 13m

Panama City Tocumen Intl

Thu 4/16

2:27 pm-11:29 am

1 stop20h 02m

$463

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

Tue 3/31

6:50 am-1:03 pm

1 stop7h 13m

Panama City Tocumen Intl

Fri 4/17

2:27 pm-11:29 am

1 stop20h 02m

$483

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, March is the cheapest month to fly from South Carolina to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $373. If you’re not able to fly to Panama City in March, then September is your next best option. Flight prices from South Carolina to Panama City during September average around $389.

Can stopping save me money on South Carolina to Panama City flights?

You could potentially save up to 2% on your flight if you consider stops on a South Carolina to Panama City flight.

Cheap South Carolina to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City

Fastest flight time

7h 07m

Direct flights

None
The fastest flight from South Carolina to Panama City takes 7h 07m
There are no direct flights from South Carolina to Panama City. There are no popular flight routes from South Carolina to Panama City.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Panama City Tocumen Intl Airport?

    Prices for flights from South Carolina to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from South Carolina to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Panama City

Compare and see reviews for airlines that fly from South Carolina to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $309Free CancellationRating
7.9
8,178 reviews
Search Delta flights
American AirlinesPriceFrom $363Free CancellationRating
7.2
11,262 reviews
Search American Airlines flights
United AirlinesPriceFrom $369Free CancellationRating
7.4
9,269 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

Finding the right flight to Panama City from South Carolina is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Panama City.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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