Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from South Carolina to Panama City from $152

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 2/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:40 pm - 4:04 am
CHS
-
PTY
9h 24m1 stop
United Airlines Logo
7:55 am - 9:59 pm
PTY
-
CHS
13h 04m1 stop
$390United Airlines
Tue, Apr 14 - Sat, Apr 18
United Airlines Logo
6:49 am - 5:07 pm
GSP
-
PTY
10h 18m1 stop
United Airlines Logo
9:55 am - 9:57 pm
PTY
-
GSP
12h 02m1 stop
$392United Airlines
Wed, Jan 21 - Wed, Feb 4
American Airlines Logo
8:17 pm - 2:22 pm
CHS
-
PTY
19h 05m2 stops
American Airlines Logo
3:13 pm - 11:59 pm
PTY
-
CHS
7h 46m1 stop
$394American Airlines
Sat, Mar 14 - Tue, Mar 17
American Airlines Logo
7:00 pm - 3:38 pm
GSP
-
PTY
20h 38m2 stops
American Airlines Logo
2:27 pm - 12:07 pm
PTY
-
GSP
21h 40m2 stops
$396American Airlines
Wed, Jan 21 - Wed, Feb 4
Multiple Airlines Logo
7:00 am - 1:00 am
CLT
-
PTY
18h 00m2 stops
Multiple Airlines Logo
5:50 pm - 12:20 pm
PTY
-
CLT
18h 30m2 stops
$437Multiple Airlines
Thu, Feb 12 - Fri, Feb 20
Multiple Airlines Logo
7:00 am - 1:00 am
CLT
-
PTY
18h 00m2 stops
Multiple Airlines Logo
2:55 pm - 12:20 pm
PTY
-
CLT
21h 25m2 stops
$453Multiple Airlines
Thu, Feb 5 - Thu, Feb 12
Delta Logo
6:54 pm - 1:55 pm
MYR
-
PTY
19h 01m1 stop
Delta Logo
3:15 pm - 9:45 am
PTY
-
MYR
18h 30m1 stop
$490Delta
Sun, Feb 1 - Wed, Mar 4
Delta Logo
10:33 am - 1:55 pm
MYR
-
PTY
27h 22m1 stop
Delta Logo
3:15 pm - 9:45 am
PTY
-
MYR
18h 30m1 stop
$510Delta
Sun, Jan 18 - Thu, Feb 12
WestJet Logo
5:45 am - 9:20 am
AGS
-
PTY
27h 35m2 stops
WestJet Logo
10:20 am - 7:55 pm
PTY
-
AGS
33h 35m2 stops
$1,701WestJet
Sat, Feb 7 - Tue, Feb 10
WestJet Logo
11:54 am - 9:20 am
AGS
-
PTY
21h 26m2 stops
WestJet Logo
10:20 am - 7:55 pm
PTY
-
AGS
33h 35m2 stops
$1,740WestJet
Sat, Feb 7 - Tue, Feb 10

United Airlines flights from South Carolina to Panama City

Our best United Airlines deals on South Carolina to Panama City flight tickets
United Airlines
Apr 14
CHS7:40 pmCharleston
9h 24m
1 stop
PTY4:04 amPanama City Tocumen Intl
Apr 18
PTY7:55 amPanama City Tocumen Intl
13h 04m
1 stop
CHS9:59 pmCharleston
$390
Find similar
United Airlines
Jan 21
GSP6:49 amGreenville
10h 18m
1 stop
PTY5:07 pmPanama City Tocumen Intl
Feb 4
PTY9:55 amPanama City Tocumen Intl
12h 02m
1 stop
GSP9:57 pmGreenville
$392
Find similar
United Airlines
Feb 5
GSP6:49 amGreenville
12h 49m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Feb 12
PTY4:41 pmPanama City Tocumen Intl
29h 18m
1 stop
GSP9:59 pmGreenville
$400
Find similar

American Airlines flights from South Carolina to Panama City

Our best American Airlines deals on South Carolina to Panama City flight tickets
American Airlines
Mar 14
CHS7:02 pmCharleston
20h 20m
2 stops
PTY2:22 pmPanama City Tocumen Intl
Mar 17
PTY1:44 pmPanama City Tocumen Intl
19h 33m
2 stops
CHS10:17 amCharleston
$394
Find similar
American Airlines
Jan 21
GSP7:00 pmGreenville
20h 38m
2 stops
PTY3:38 pmPanama City Tocumen Intl
Feb 4
PTY2:27 pmPanama City Tocumen Intl
21h 40m
2 stops
GSP12:07 pmGreenville
$396
Find similar
American Airlines
Jan 29
GSP5:40 pmGreenville
21h 58m
2 stops
PTY3:38 pmPanama City Tocumen Intl
Feb 3
PTY2:27 pmPanama City Tocumen Intl
25h 23m
2 stops
GSP3:50 pmGreenville
$397
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 4/14

7:40 pm-4:04 am

1 stop9h 24m

Panama City Tocumen Intl

Sat 4/18

7:55 am-9:59 pm

1 stop13h 04m

$390

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:49 am-5:07 pm

1 stop10h 18m

Panama City Tocumen Intl

Wed 2/4

9:55 am-9:57 pm

1 stop12h 02m

$392

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 3/14

8:17 pm-2:22 pm

2 stops19h 05m

Panama City Tocumen Intl

Tue 3/17

3:13 pm-11:59 pm

1 stop7h 46m

$394

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

7:00 pm-3:38 pm

2 stops20h 38m

Panama City Tocumen Intl

Wed 2/4

2:27 pm-12:07 pm

2 stops21h 40m

$396

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 2/12

7:00 am-1:00 am

2 stops18h 00m

Panama City Tocumen Intl

Fri 2/20

5:50 pm-12:20 pm

2 stops18h 30m

$437

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 2/5

7:00 am-1:00 am

2 stops18h 00m

Panama City Tocumen Intl

Thu 2/12

2:55 pm-12:20 pm

2 stops21h 25m

$453

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sun 2/1

6:54 pm-1:55 pm

1 stop19h 01m

Panama City Tocumen Intl

Wed 3/4

3:15 pm-9:45 am

1 stop18h 30m

$490

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sun 1/18

10:33 am-1:55 pm

1 stop27h 22m

Panama City Tocumen Intl

Thu 2/12

3:15 pm-9:45 am

1 stop18h 30m

$510

AugustaPanama City

AGS - PTY

AGSPTY

Augusta Bush Field

Sat 2/7

5:45 am-9:20 am

2 stops27h 35m

Panama City Tocumen Intl

Tue 2/10

10:20 am-7:55 pm

2 stops33h 35m

$1,701

AugustaPanama City

AGS - PTY

AGSPTY

Augusta Bush Field

Sat 2/7

11:54 am-9:20 am

2 stops21h 26m

Panama City Tocumen Intl

Tue 2/10

10:20 am-7:55 pm

2 stops33h 35m

$1,740

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, September is the cheapest month to fly from South Carolina to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $389. If you’re not able to fly to Panama City in September, then March is your next best option. Flight prices from South Carolina to Panama City during March average around $413.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $341. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $712. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from South Carolina to Panama City during this time can be as low as $466. Try not to purchase tickets in the afternoon because they tend to be around $495. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on South Carolina to Panama City flights?

You could potentially save up to 1% on your flight if you consider stops on a South Carolina to Panama City flight.

Cheap South Carolina to Panama City flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City

Fastest flight time

6h 55m

Direct flights

None
The fastest flight from South Carolina to Panama City takes 6h 55m
There are no direct flights from South Carolina to Panama City. There are no popular flight routes from South Carolina to Panama City.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Panama City Tocumen Intl Airport?

    Prices for flights from South Carolina to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from South Carolina to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Panama City

Compare and see reviews for airlines that fly from South Carolina to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $349Free CancellationRating
7.9
8,014 reviews
Search Delta flights
American AirlinesPriceFrom $363Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
United AirlinesPriceFrom $369Free CancellationRating
7.4
9,105 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

Finding the right flight to Panama City from South Carolina is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Panama City.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Panama City trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 1/22
Thu 1/29
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Panama