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Cheap flights from South Carolina to Guayaquil from $125

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Guayaquil departing on 5/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Guayaquil

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
11:12 am - 12:04 am
CLT
-
GYE
12h 52m
2 stops
Spirit Airlines Logo
12:59 am - 6:18 pm
GYE
-
CLT
17h 19m
1 stop
$283Spirit Airlines
Wed, Feb 18 - Sun, Mar 1
Spirit Airlines Logo
11:12 am - 12:04 am
CLT
-
GYE
12h 52m
2 stops
Spirit Airlines Logo
12:59 am - 4:54 pm
GYE
-
CLT
15h 55m
2 stops
$292Spirit Airlines
Wed, Feb 18 - Sun, Mar 1
American Airlines Logo
8:21 pm - 1:31 pm
CHS
-
GYE
18h 10m
2 stops
American Airlines Logo
2:31 pm - 9:52 am
GYE
-
CHS
18h 21m
2 stops
$294American Airlines
Mon, May 4 - Mon, May 18
American Airlines Logo
8:21 pm - 1:31 pm
CHS
-
GYE
18h 10m
2 stops
American Airlines Logo
2:31 pm - 10:24 am
GYE
-
CHS
18h 53m
1 stop
$300American Airlines
Mon, May 4 - Mon, May 18
Spirit Airlines Logo
1:24 pm - 12:04 am
CLT
-
GYE
10h 40m
1 stop
Spirit Airlines Logo
12:13 am - 8:23 pm
GYE
-
CLT
19h 10m
1 stop
$300Spirit Airlines
Thu, Feb 19 - Sun, Mar 15
Spirit Airlines Logo
11:12 am - 12:04 am
CLT
-
GYE
12h 52m
2 stops
Spirit Airlines Logo
12:59 am - 4:54 pm
GYE
-
CLT
15h 55m
2 stops
$302Spirit Airlines
Wed, Feb 18 - Sun, Mar 1
Multiple Airlines Logo
8:56 am - 11:18 pm
CLT
-
GYE
15h 22m
1 stop
Multiple Airlines Logo
12:13 am - 2:17 pm
GYE
-
CLT
13h 04m
1 stop
$330Multiple Airlines
Thu, Mar 12 - Thu, Mar 19
Multiple Airlines Logo
3:01 pm - 11:04 pm
CHS
-
GYE
33h 03m
2 stops
Multiple Airlines Logo
11:59 pm - 10:33 pm
GYE
-
CHS
21h 34m
1 stop
$356Multiple Airlines
Tue, Mar 17 - Fri, Mar 27
LATAM Airlines Logo
2:19 pm - 10:27 am
MYR
-
GYE
20h 08m
2 stops
LATAM Airlines Logo
3:00 pm - 9:46 am
GYE
-
MYR
18h 46m
2 stops
$925LATAM Airlines
Mon, Feb 2 - Thu, Feb 5
LATAM Airlines Logo
10:33 am - 10:27 am
MYR
-
GYE
23h 54m
2 stops
LATAM Airlines Logo
3:00 pm - 9:46 am
GYE
-
MYR
18h 46m
2 stops
$935LATAM Airlines
Mon, Feb 2 - Thu, Feb 5

Spirit Airlines flights from South Carolina to Guayaquil

Our best Spirit Airlines deals on South Carolina to Guayaquil flight tickets
Spirit Airlines
Feb 18
CLT11:12 amCharlotte Douglas
12h 52m
2 stops
GYE12:04 amGuayaquil Jose Joaquin de Olmedo
Mar 1
GYE12:59 amGuayaquil Jose Joaquin de Olmedo
17h 19m
1 stop
CLT6:18 pmCharlotte Douglas
$283
Spirit Airlines
Feb 18
CLT11:12 amCharlotte Douglas
12h 52m
2 stops
GYE12:04 amGuayaquil Jose Joaquin de Olmedo
Mar 1
GYE12:59 amGuayaquil Jose Joaquin de Olmedo
15h 55m
2 stops
CLT4:54 pmCharlotte Douglas
$292
Spirit Airlines
Feb 19
CLT1:24 pmCharlotte Douglas
10h 40m
1 stop
GYE12:04 amGuayaquil Jose Joaquin de Olmedo
Mar 15
GYE12:13 amGuayaquil Jose Joaquin de Olmedo
19h 10m
1 stop
CLT8:23 pmCharlotte Douglas
$300

American Airlines flights from South Carolina to Guayaquil

Our best American Airlines deals on South Carolina to Guayaquil flight tickets
American Airlines
May 4
CHS8:21 pmCharleston
18h 10m
2 stops
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
May 18
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
18h 21m
2 stops
CHS9:52 amCharleston
$294
American Airlines
May 4
CHS8:21 pmCharleston
18h 10m
2 stops
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
May 18
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
18h 53m
1 stop
CHS10:24 amCharleston
$300
American Airlines
Feb 14
CHS8:17 pmCharleston
18h 13m
2 stops
GYE2:30 pmGuayaquil Jose Joaquin de Olmedo
Feb 20
GYE3:30 pmGuayaquil Jose Joaquin de Olmedo
18h 25m
1 stop
CHS9:55 amCharleston
$459

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from South Carolina to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Wed 2/18

11:12 am-12:04 am

2 stops12h 52m

Guayaquil Jose Joaquin de Olmedo

Sun 3/1

12:59 am-6:18 pm

1 stop17h 19m

$283

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Wed 2/18

11:12 am-12:04 am

2 stops12h 52m

Guayaquil Jose Joaquin de Olmedo

Sun 3/1

12:59 am-4:54 pm

2 stops15h 55m

$292

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Mon 5/4

8:21 pm-1:31 pm

2 stops18h 10m

Guayaquil Jose Joaquin de Olmedo

Mon 5/18

2:31 pm-9:52 am

2 stops18h 21m

$294

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Mon 5/4

8:21 pm-1:31 pm

2 stops18h 10m

Guayaquil Jose Joaquin de Olmedo

Mon 5/18

2:31 pm-10:24 am

1 stop18h 53m

$300

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 2/19

1:24 pm-12:04 am

1 stop10h 40m

Guayaquil Jose Joaquin de Olmedo

Sun 3/15

12:13 am-8:23 pm

1 stop19h 10m

$300

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Wed 2/18

11:12 am-12:04 am

2 stops12h 52m

Guayaquil Jose Joaquin de Olmedo

Sun 3/1

12:59 am-4:54 pm

2 stops15h 55m

$302

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 3/12

8:56 am-11:18 pm

1 stop15h 22m

Guayaquil Jose Joaquin de Olmedo

Thu 3/19

12:13 am-2:17 pm

1 stop13h 04m

$330

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Tue 3/17

3:01 pm-11:04 pm

2 stops33h 03m

Guayaquil Jose Joaquin de Olmedo

Fri 3/27

11:59 pm-10:33 pm

1 stop21h 34m

$356

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Mon 2/2

2:19 pm-10:27 am

2 stops20h 08m

Guayaquil Jose Joaquin de Olmedo

Thu 2/5

3:00 pm-9:46 am

2 stops18h 46m

$925

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Mon 2/2

10:33 am-10:27 am

2 stops23h 54m

Guayaquil Jose Joaquin de Olmedo

Thu 2/5

3:00 pm-9:46 am

2 stops18h 46m

$935

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Guayaquil from

How to get the cheapest flight ticket from South Carolina to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on South Carolina to Guayaquil flights?

You could potentially save up to 79% on your flight if you consider stops on a South Carolina to Guayaquil flight.

Cheap South Carolina to Guayaquil flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Guayaquil

Fastest flight time

9h 59m

Direct flights

None
The fastest flight from South Carolina to Guayaquil takes 9h 59m
There are no direct flights from South Carolina to Guayaquil. There are no popular flight routes from South Carolina to Guayaquil.
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from South Carolina to Guayaquil Jose Joaquin de Olmedo Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Guayaquil Jose Joaquin de Olmedo Airport?

  • How old do you have to be to fly from South Carolina to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The travel and health documents required for your trip to Guayaquil Jose Joaquin de Olmedo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Guayaquil Jose Joaquin de Olmedo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Guayaquil

Compare and see reviews for airlines that fly from South Carolina to Guayaquil with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $863Free CancellationRating
7.2
11,119 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Guayaquil?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Guayaquil from South Carolina.

Can I find flights from South Carolina to Guayaquil with flexible booking policies on momondo?

momondo does allow users to show only those flights to Guayaquil from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Guayaquil?

Once all potential South Carolina to Guayaquil flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to Guayaquil right now. Can momondo alert me if prices change?

Price alerts on flights to Guayaquil from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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