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Cheap flights from South Carolina to Detroit from $99

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Detroit departing on 9/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Detroit

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
5:19 pm - 10:45 pm
CHS
-
DTW
5h 26m
1 stop
JetBlue Logo
7:30 am - 4:23 pm
DTW
-
CHS
8h 53m
1 stop
$217JetBlue
Tue, Jul 14 - Wed, Jul 22
JetBlue Logo
5:19 pm - 10:45 pm
CHS
-
DTW
5h 26m
1 stop
JetBlue Logo
7:30 am - 4:23 pm
DTW
-
CHS
8h 53m
1 stop
$222JetBlue
Tue, Jul 14 - Tue, Jul 21
Multiple Airlines Logo
12:19 pm - 12:55 pm
SAV
-
DTW
24h 36m
1 stop
Multiple Airlines Logo
9:12 am - 1:55 pm
DTW
-
SAV
28h 43m
1 stop
$232Multiple Airlines
Wed, Jul 15 - Wed, Jul 22
Multiple Airlines Logo
3:48 pm - 12:55 pm
GSP
-
DTW
21h 07m
1 stop
Multiple Airlines Logo
9:12 am - 7:57 am
DTW
-
GSP
22h 45m
1 stop
$234Multiple Airlines
Wed, Jul 8 - Sat, Jul 18
Southwest Logo
2:25 pm - 9:15 pm
MYR
-
DTW
6h 50m
1 stop
Southwest Logo
2:45 pm - 7:10 pm
DTW
-
MYR
4h 25m
1 stop
$236Southwest
Tue, Aug 25 - Tue, Sep 1
Southwest Logo
5:10 pm - 9:15 pm
CHS
-
DTW
4h 05m
1 stop
Southwest Logo
6:00 am - 12:50 pm
DTW
-
CHS
6h 50m
1 stop
$236Southwest
Tue, Aug 11 - Tue, Aug 25
Delta Logo
7:39 pm - 12:59 am
CAE
-
DTW
5h 20m
1 stop
Delta Logo
6:17 am - 11:14 am
DTW
-
CAE
4h 57m
1 stop
$309Delta
Thu, Jul 9 - Tue, Jul 21
American Airlines Logo
2:48 pm - 7:18 pm
HHH
-
DTW
4h 30m
1 stop
American Airlines Logo
7:00 am - 12:20 pm
DTW
-
HHH
5h 20m
1 stop
$313American Airlines
Thu, Jul 2 - Sun, Jul 5
Delta Logo
7:39 pm - 12:59 am
CAE
-
DTW
5h 20m
1 stop
Delta Logo
6:17 am - 12:59 pm
DTW
-
CAE
6h 42m
1 stop
$319Delta
Thu, Jul 9 - Sat, Jul 11
American Airlines Logo
2:48 pm - 7:13 pm
HHH
-
DTW
4h 25m
1 stop
American Airlines Logo
6:00 am - 11:17 am
DTW
-
HHH
5h 17m
1 stop
$323American Airlines
Wed, Jul 8 - Wed, Jul 15

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Southwest flights from South Carolina to Detroit Metropolitan Wayne County Airport

Our best Southwest deals on South Carolina to Detroit Metropolitan Wayne County Airport flight tickets
Southwest
Aug 25
MYR5:05 pmMyrtle Beach Intl
4h 10m
1 stop
DTW9:15 pmDetroit Metropolitan Wayne County
Sep 15
DTW2:45 pmDetroit Metropolitan Wayne County
4h 25m
1 stop
MYR7:10 pmMyrtle Beach Intl
$236
Southwest
Aug 25
MYR7:50 amMyrtle Beach Intl
7h 10m
1 stop
DTW3:00 pmDetroit Metropolitan Wayne County
Sep 1
DTW6:25 amDetroit Metropolitan Wayne County
9h 40m
2 stops
MYR4:05 pmMyrtle Beach Intl
$241
Southwest
Aug 13
MYR3:20 pmMyrtle Beach Intl
6h 55m
1 stop
DTW10:15 pmDetroit Metropolitan Wayne County
Aug 18
DTW12:55 pmDetroit Metropolitan Wayne County
4h 45m
1 stop
MYR5:40 pmMyrtle Beach Intl
$259

Delta flights from South Carolina to Detroit Metropolitan Wayne County Airport

Our best Delta deals on South Carolina to Detroit Metropolitan Wayne County Airport flight tickets
Delta
Aug 25
MYR11:33 amMyrtle Beach Intl
1h 57m
DTW1:30 pmDetroit Metropolitan Wayne County
Sep 1
DTW8:41 amDetroit Metropolitan Wayne County
1h 57m
MYR10:38 amMyrtle Beach Intl
$299
Delta
Jul 9
CAE7:39 pmColumbia Metropolitan
5h 20m
1 stop
DTW12:59 amDetroit Metropolitan Wayne County
Jul 21
DTW6:17 amDetroit Metropolitan Wayne County
4h 57m
1 stop
CAE11:14 amColumbia Metropolitan
$309
Delta
Jul 9
CAE7:39 pmColumbia Metropolitan
5h 20m
1 stop
DTW12:59 amDetroit Metropolitan Wayne County
Jul 11
DTW6:17 amDetroit Metropolitan Wayne County
6h 42m
1 stop
CAE12:59 pmColumbia Metropolitan
$319

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Detroit Metropolitan Wayne County Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 13, 2026.
Use the filters below to find and compare flights from South Carolina to Detroit Metropolitan Wayne County Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonDetroit

CHS - DTW

CHSDTW

Charleston

Tue 7/14

5:19 pm-10:45 pm

1 stop5h 26m

Detroit Metropolitan Wayne County

Wed 7/22

7:30 am-4:23 pm

1 stop8h 53m

$217

CharlestonDetroit

CHS - DTW

CHSDTW

Charleston

Tue 7/14

5:19 pm-10:45 pm

1 stop5h 26m

Detroit Metropolitan Wayne County

Tue 7/21

7:30 am-4:23 pm

1 stop8h 53m

$222

SavannahDetroit

SAV - DTW

SAVDTW

Savannah/Hilton Head

Wed 7/15

12:19 pm-12:55 pm

1 stop24h 36m

Detroit Metropolitan Wayne County

Wed 7/22

9:12 am-1:55 pm

1 stop28h 43m

$232

GreenvilleDetroit

GSP - DTW

GSPDTW

Greenville

Wed 7/8

3:48 pm-12:55 pm

1 stop21h 07m

Detroit Metropolitan Wayne County

Sat 7/18

9:12 am-7:57 am

1 stop22h 45m

$234

Myrtle BeachDetroit

MYR - DTW

MYRDTW

Myrtle Beach Intl

Tue 8/25

2:25 pm-9:15 pm

1 stop6h 50m

Detroit Metropolitan Wayne County

Tue 9/1

2:45 pm-7:10 pm

1 stop4h 25m

$236

CharlestonDetroit

CHS - DTW

CHSDTW

Charleston

Tue 8/11

5:10 pm-9:15 pm

1 stop4h 05m

Detroit Metropolitan Wayne County

Tue 8/25

6:00 am-12:50 pm

1 stop6h 50m

$236

ColumbiaDetroit

CAE - DTW

CAEDTW

Columbia Metropolitan

Thu 7/9

7:39 pm-12:59 am

1 stop5h 20m

Detroit Metropolitan Wayne County

Tue 7/21

6:17 am-11:14 am

1 stop4h 57m

$309

Hilton Head IslandDetroit

HHH - DTW

HHHDTW

Hilton Head Island

Thu 7/2

2:48 pm-7:18 pm

1 stop4h 30m

Detroit Metropolitan Wayne County

Sun 7/5

7:00 am-12:20 pm

1 stop5h 20m

$313

ColumbiaDetroit

CAE - DTW

CAEDTW

Columbia Metropolitan

Thu 7/9

7:39 pm-12:59 am

1 stop5h 20m

Detroit Metropolitan Wayne County

Sat 7/11

6:17 am-12:59 pm

1 stop6h 42m

$319
Quickest round-trip

Hilton Head IslandDetroit

HHH - DTW

HHHDTW

Hilton Head Island

Wed 7/8

2:48 pm-7:13 pm

1 stop4h 25m

Detroit Metropolitan Wayne County

Wed 7/15

6:00 am-11:17 am

1 stop5h 17m

$323

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Detroit from

How to get the cheapest flight ticket from South Carolina to Detroit Metropolitan Wayne County Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Detroit Metropolitan Wayne County Airport?

The cheapest month to fly to Detroit Metropolitan Wayne County Airport from South Carolina is in July. Flight prices, which tend to average around $60, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of July, then book flights to Detroit Metropolitan Wayne County Airport from South Carolina during June instead. Flights to Detroit Metropolitan Wayne County Airport in June, while not as cheap as those in July, still average around $62.

What is the cheapest day to depart on your flight to Detroit Metropolitan Wayne County Airport?

The cheapest day to depart from South Carolina to Detroit Metropolitan Wayne County Airport is on a Friday when prices can be found for as low as $351. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Detroit Metropolitan Wayne County Airport on Sunday is $753.

What is the cheapest time of day to depart on your flight to Detroit Metropolitan Wayne County Airport?

Flying to Detroit Metropolitan Wayne County Airport from South Carolina in the morning is the least expensive time of day to depart. momondo users have found prices as low as $393 when looking at flights departing in the morning. Flights to Detroit Metropolitan Wayne County Airport are more costly in the afternoon, with an average ticket price of $480. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest South Carolina to Detroit Metropolitan Wayne County flight route?

Fly from Myrtle Beach Intl to Detroit Metropolitan Wayne County for the best South Carolina - Detroit Metropolitan Wayne County flight prices

How far in advance should I book a flight from South Carolina to Detroit Metropolitan Wayne County Airport?

You are more likely to see cheaper flights to Detroit Metropolitan Wayne County Airport from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Detroit Metropolitan Wayne County Airport for around $328 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Detroit Metropolitan Wayne County Airport from South Carolina for as low as $230 on momondo.

What cabin class options are available on South Carolina to Detroit Metropolitan Wayne County Airport flights?

There are 4 cabin classes available to choose from on South Carolina to Detroit Metropolitan Wayne County Airport flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to Detroit Metropolitan Wayne County Airport flights?

You could potentially save up to 27% on your flight if you consider stops on a South Carolina to Detroit Metropolitan Wayne County Airport flight.

Cheap South Carolina to Detroit Metropolitan Wayne County Airport flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Detroit Metropolitan Wayne County Airport

Best Price Found

$172

Fastest flight time

1h 42m

Direct flights

Every day
The best one-way flight to Detroit Metropolitan Wayne County Airport from South Carolina in the past 72 hours is $172. The best round-trip flight deal from South Carolina to Detroit Metropolitan Wayne County Airport found on momondo in the last 72 hours is $339.
The fastest flight from South Carolina to Detroit Metropolitan Wayne County Airport takes 1h 42m
Direct flights go from South Carolina to Detroit Metropolitan Wayne County Airport every day.
Search flight deals

Frequently asked questions about flying from South Carolina to Detroit Metropolitan Wayne County Airport

  • When did momondo last update prices for flights from South Carolina to Detroit Metropolitan Wayne County Airport?

    Prices for flights from South Carolina to Detroit Metropolitan Wayne County Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Detroit Metropolitan Wayne County Airport?

  • How old do you have to be to fly from South Carolina to Detroit Metropolitan Wayne County Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from South Carolina to Detroit Metropolitan Wayne County Airport.

  • What documentation or ID do you need to fly to Detroit Metropolitan Wayne County Airport?

    The travel and health documents you'll need for your trip to Detroit Metropolitan Wayne County Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Detroit Metropolitan Wayne County Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from South Carolina to Detroit Metropolitan Wayne County Airport?

Best airlines flying from South Carolina to Detroit Metropolitan Wayne County Airport

Compare and see reviews for airlines that fly from South Carolina to Detroit Metropolitan Wayne County Airport with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $140Free CancellationRating
7.9
8,405 reviews
Search Delta flights
American AirlinesPriceFrom $198Free CancellationRating
7.1
11,648 reviews
Search American Airlines flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
9,815 reviews
Search United Airlines flights

Traveling to a place near Detroit?

Book flights to Detroit if you plan to visit one of these locations
Put-in-Bay
Auburn Hills
Romulus
Warren
Dearborn
Troy
Monroe
Southfield
Livonia
Novi
Port Clinton
Roseville
Port Huron
Sterling Heights
Dundee
Ypsilanti
Pontiac
Brighton
Belleville
Madison Heights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Detroit?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South Carolina to Detroit. momondo saves you time and could save you money on your trip.

Can I find flights from South Carolina to Detroit with flexible booking policies on momondo?

momondo does allow users to show only those flights to Detroit from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Detroit?

Once you have performed a search for South Carolina to Detroit flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Detroit right now. Can momondo alert me if prices change?

If you are not ready to book a flight from South Carolina to Detroit now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Detroit and let you know when they change.

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