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Cheap flights from South Carolina to the Cayman Islands from $169

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to the Cayman Islands departing on 11/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from South Carolina to the Cayman Islands

Cheap round-trip flights

Spirit Airlines Logo
5:45 am - 11:00 amCLT-GCM
5h 15m1 stop
Spirit Airlines Logo
11:55 am - 12:59 amGCM-CLT
13h 04m1 stop
$436Spirit Airlines
Find Deal
Sat, Jan 17 - Sat, Jan 24
Logo
12:38 pm - 5:20 pmCLT-GCM
5h 42m1 stop
Logo
12:40 pm - 7:05 pmGCM-CLT
5h 25m1 stop
$445
Find Deal
Mon, Sep 8 - Mon, Sep 15
Logo
7:24 pm - 2:50 pmCLT-GCM
20h 26m2 stops
Logo
7:00 am - 6:29 pmGCM-CLT
10h 29m1 stop
$452
Find Deal
Fri, Oct 17 - Sun, Oct 19
Delta Logo
5:30 am - 12:37 pmCHS-GCM
7h 07m1 stop
Delta Logo
2:02 pm - 9:19 pmGCM-CHS
7h 17m1 stop
$472Delta
Find Deal
Mon, Dec 15 - Fri, Dec 19
American Airlines Logo
7:08 am - 11:10 amCHS-GCM
5h 02m1 stop
American Airlines Logo
12:25 pm - 11:59 pmGCM-CHS
10h 34m2 stops
$476American Airlines
Find Deal
Wed, Oct 1 - Wed, Oct 8
Air Canada Logo
8:30 am - 11:55 amCLT-GCM
28h 25m1 stop
Air Canada Logo
12:50 pm - 9:22 pmGCM-CLT
7h 32m1 stop
$476Air Canada
Find Deal
Wed, Sep 3 - Mon, Sep 15
American Airlines Logo
9:42 am - 1:10 pmCHS-GCM
4h 28m1 stop
American Airlines Logo
12:10 pm - 9:39 pmGCM-CHS
8h 29m2 stops
$489American Airlines
Find Deal
Thu, Oct 9 - Thu, Oct 16
Delta Logo
5:30 am - 12:37 pmCHS-GCM
7h 07m1 stop
Delta Logo
1:55 pm - 11:58 pmGCM-CHS
10h 03m1 stop
$497Delta
Find Deal
Mon, Dec 15 - Sun, Dec 21
Southwest Logo
7:45 am - 3:15 pmGSP-GCM
7h 30m1 stop
Southwest Logo
1:30 pm - 10:00 amGCM-GSP
20h 30m2 stops
$515Southwest
Find Deal
Sat, Nov 29 - Sun, Dec 7
Air Canada Logo
9:35 am - 11:55 amGSP-GCM
27h 20m2 stops
Air Canada Logo
12:50 pm - 10:46 pmGCM-GSP
32h 56m2 stops
$950Air Canada
Find Deal
Wed, Sep 3 - Mon, Sep 15

American Airlines flights from South Carolina to Cayman Islands

Our best American Airlines deals on South Carolina to Cayman Islands flight tickets
American Airlines
Oct 1
CHS7:08 amCharleston
5h 02m
1 stop
GCM11:10 amGeorge Town Owen Roberts Intl
Oct 8
GCM12:25 pmGeorge Town Owen Roberts Intl
10h 34m
2 stops
CHS11:59 pmCharleston
$476
Find similar
American Airlines
Oct 9
CHS9:42 amCharleston
4h 28m
1 stop
GCM1:10 pmGeorge Town Owen Roberts Intl
Oct 16
GCM12:10 pmGeorge Town Owen Roberts Intl
8h 29m
2 stops
CHS9:39 pmCharleston
$489
Find similar
American Airlines
Dec 2
SAV8:17 pmSavannah/Hilton Head
15h 29m
1 stop
GCM11:46 amGeorge Town Owen Roberts Intl
Dec 5
GCM4:15 pmGeorge Town Owen Roberts Intl
4h 55m
1 stop
SAV9:10 pmSavannah/Hilton Head
$491
Find similar

Air Canada flights from South Carolina to Cayman Islands

Our best Air Canada deals on South Carolina to Cayman Islands flight tickets
Air Canada
Sep 3
CLT8:30 amCharlotte Douglas
28h 25m
1 stop
GCM11:55 amGeorge Town Owen Roberts Intl
Sep 15
GCM12:50 pmGeorge Town Owen Roberts Intl
7h 32m
1 stop
CLT9:22 pmCharlotte Douglas
$476
Find similar
Air Canada
Sep 3
GSP9:35 amGreenville
27h 20m
2 stops
GCM11:55 amGeorge Town Owen Roberts Intl
Sep 15
GCM12:50 pmGeorge Town Owen Roberts Intl
32h 56m
2 stops
GSP10:46 pmGreenville
$950
Find similar
Air Canada
Aug 26
GSP6:07 pmGreenville
42h 48m
2 stops
GCM11:55 amGeorge Town Owen Roberts Intl
Sep 4
GCM12:50 pmGeorge Town Owen Roberts Intl
33h 10m
2 stops
GSP11:00 pmGreenville
$1,470
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Cayman Islands that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2025.
Use the filters below to find and compare flights from South Carolina to the Cayman Islands that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Sat 1/17

5:45 am-11:00 am

1 stop5h 15m

George Town Owen Roberts Intl

Sat 1/24

11:55 am-12:59 am

1 stop13h 04m

$436

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Mon 9/8

12:38 pm-5:20 pm

1 stop5h 42m

George Town Owen Roberts Intl

Mon 9/15

12:40 pm-7:05 pm

1 stop5h 25m

$445

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Fri 10/17

7:24 pm-2:50 pm

2 stops20h 26m

George Town Owen Roberts Intl

Sun 10/19

7:00 am-6:29 pm

1 stop10h 29m

$452

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Mon 12/15

5:30 am-12:37 pm

1 stop7h 07m

George Town Owen Roberts Intl

Fri 12/19

2:02 pm-9:19 pm

1 stop7h 17m

$472

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Wed 10/1

7:08 am-11:10 am

1 stop5h 02m

George Town Owen Roberts Intl

Wed 10/8

12:25 pm-11:59 pm

2 stops10h 34m

$476

CharlotteGeorge Town

CLT - GCM

CLTGCM

Charlotte Douglas

Wed 9/3

8:30 am-11:55 am

1 stop28h 25m

George Town Owen Roberts Intl

Mon 9/15

12:50 pm-9:22 pm

1 stop7h 32m

$476

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Thu 10/9

9:42 am-1:10 pm

1 stop4h 28m

George Town Owen Roberts Intl

Thu 10/16

12:10 pm-9:39 pm

2 stops8h 29m

$489

CharlestonGeorge Town

CHS - GCM

CHSGCM

Charleston

Mon 12/15

5:30 am-12:37 pm

1 stop7h 07m

George Town Owen Roberts Intl

Sun 12/21

1:55 pm-11:58 pm

1 stop10h 03m

$497

GreenvilleGeorge Town

GSP - GCM

GSPGCM

Greenville

Sat 11/29

7:45 am-3:15 pm

1 stop7h 30m

George Town Owen Roberts Intl

Sun 12/7

1:30 pm-10:00 am

2 stops20h 30m

$515

GreenvilleGeorge Town

GSP - GCM

GSPGCM

Greenville

Wed 9/3

9:35 am-11:55 am

2 stops27h 20m

George Town Owen Roberts Intl

Mon 9/15

12:50 pm-10:46 pm

2 stops32h 56m

$950

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to the Cayman Islands from

How to get the cheapest flight ticket from South Carolina to Cayman Islands

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Cayman Islands?

If you aren’t able to travel to Cayman Islands during the month of January, then flying in November is also cheap. Prices for this month can be found on momondo for an average of $504.

What is the cheapest day to depart on your flight to Cayman Islands?

Our data shows that Wednesday is the least expensive day to fly to Cayman Islands. Tickets to fly out on this day can be as low as $488. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Cayman Islands on Saturday is $716.

Cheap South Carolina to Cayman Islands flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Cayman Islands

Best Price Found

$169

Fastest flight time

4h 16m

Direct flights

Tue, Thu, Fri, Sat and Sun

Airports in Cayman Islands

1 airport
The best one-way flight to Cayman Islands from South Carolina in the past 72 hours is $169. The best round-trip flight deal from South Carolina to Cayman Islands found on momondo in the last 72 hours is $436.
The fastest flight from South Carolina to Cayman Islands takes 4h 16m
Direct flights go from South Carolina to Cayman Islands on Tuesday, Thursday, Friday, Saturday and Sunday. The only airline offering direct flights is American Airlines.
There is 1 airport near Cayman Islands: George Town Owen Roberts Intl (GCM)
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Cayman Islands?

    Prices for flights from South Carolina to Cayman Islands are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Cayman Islands?

  • How old do you have to be to fly from South Carolina to Cayman Islands?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Cayman Islands.

  • What documentation or ID do you need to fly to Cayman Islands?

    The travel and health documents you'll need for your trip to Cayman Islands may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Cayman Islands. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Cayman Islands

Compare and see reviews for airlines that fly from South Carolina to Cayman Islands with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $428Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $460Free CancellationRating
8.0
7,979 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Cayman Islands?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South Carolina to Cayman Islands. momondo saves you time and could save you money on your trip.

Can I find flights from South Carolina to Cayman Islands with flexible booking policies on momondo?

momondo does allow users to show only those flights to Cayman Islands from South Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from South Carolina to Cayman Islands?

momondo provides multiple filters to help you find the best flight to Cayman Islands from South Carolina. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from South Carolina to Cayman Islands right now. Can momondo alert me if prices change?

Price alerts on flights to Cayman Islands from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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Find better results for your trip to the Cayman Islands

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