Cheap flights from Sao Paulo to Santiago from $105

In general, March is the cheapest month to fly from Sao Paulo to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $253. If you don’t want to visit Santiago in March, then you should wait until November to fly from Sao Paulo, when ticket prices are also cheap, with an average price of $259.

The cheapest day to depart on your flight to Santiago is on a Friday when prices can be found for as low as $327. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Tuesday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Tuesday is $448.

In the evening is the cheapest time of day to fly from Sao Paulo to Santiago when you can find flight prices for as low as $360. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $512 per ticket.

Fly from Sao Paulo Guarulhos Intl to Santiago Arturo Merino Benitez for the best Sao Paulo - Santiago Arturo Merino Benitez flight prices

You are more likely to see cheaper flights to Santiago from Sao Paulo when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $294 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Sao Paulo for as low as $256 on momondo.

There are 3 cabin classes available to choose from on Sao Paulo to Santiago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 17% on your flight if you consider stops on a Sao Paulo to Santiago flight.

As of September 2026, prices for Sao Paulo to Santiago flights are approximately 61% more expensive when compared to flights at the same time last year.

Sky Airline, Turkish Airlines, and LATAM Airlines are the most popular carriers operating from Sao Paulo to Santiago Arturo Merino Benitez

LATAM Airlines, JetSMART and Sky Airline are the top three most popular airlines that fly to Santiago from Sao Paulo according to our data. LATAM Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 4 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Historically, on average around 26% of flights between Sao Paulo and Santiago have experienced a delay on any given week. The average delay length over the past 12 months has been 120 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights at night have, in the past, seen delays more frequently in comparison.

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Friday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the least number of delays on this route over the last 12 months; with about 27% of their flights experiencing any sort of delay.

As of September 2026, there are 11 flights per day flying from Sao Paulo to Santiago. The most common time of day flights depart is 2:00PM, with 35% of flights taking off in the afternoon.

The number of flights available between Sao Paulo and Santiago is 81 per week as of September 2026. The most frequent departure day is Fri, with 31% of weekly flights leaving on this day.