Cheap flights from Santiago to Mexico City from $327

The cheapest month to fly to Mexico City from Santiago is in November. Flight prices, which tend to average around $570, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to Mexico City from Santiago during March instead. Flights to Mexico City in March, while not as cheap as those in November, still average around $573.

Our data shows that Monday is the least expensive day to fly to Mexico City. Tickets to fly out on this day can be as low as $615. On the other hand, Sunday is the most expensive day to depart from Santiago because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $918.

According to our data, the cheapest time of day to fly to Mexico City is in the evening. momondo users have found flights departing from Santiago to Mexico City in the evening for as low as $654. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the morning is when there is more demand to fly to Mexico City, so prices are often more expensive at around $875 per ticket.

Fly from Santiago Arturo Merino Benitez to Mexico City Benito Juarez for the best Santiago Arturo Merino Benitez - Mexico City Benito Juarez flight prices

You are more likely to see cheaper flights to Mexico City from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Mexico City for around $620 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Mexico City from Santiago for as low as $545 on momondo.

There are 3 cabin classes available to choose from on Santiago to Mexico City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Santiago to Mexico City.

As of April 2026, prices for Santiago to Mexico City flights are approximately 19% more expensive when compared to flights at the same time last year.

Copa Airlines is the most popular carrier operating from Santiago Arturo Merino Benitez to Mexico City Benito Juarez

LATAM Airlines, Copa Airlines and Avianca are the top three most popular airlines that fly to Mexico City from Santiago according to our data. LATAM Airlines is the first choice among our users, with 72% of people opting to fly with this airline when traveling to Mexico City. Keep in mind that there are 4 different airlines that fly to Mexico City on a routine basis, so you have a few additional options to choose from.

Historically, on average around 14% of flights between Santiago and Mexico City have experienced a delay on any given week. The average delay length over the past 12 months has been 181 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the morning have, in the past, seen delays more frequently in comparison.

Friday is statistically the day of the week which experiences the fewest number of delays on this flight route. Monday has historically seen more delays on average compared to the rest of the week.

According to our data, Aeromexico have had the least number of delays on this route over the last 12 months; with about 8% of their flights experiencing any sort of delay.

Panama City (PTY) was the most common stop: 63% of momondo users choosing 1-stop flights on this route connected there.

Flights via Panama City (PTY) offer the lowest average round-trip price of $659.

Flights connecting via Lima (LIM) have the shortest average one-way travel time: 11h 35m.

Lima (LIM) has the shortest average layover time for this route: 1h 28m.