Cheap flights from Santiago to Mexico City from $305

The cheapest month to fly to Mexico City from Santiago is in November. Flight prices, which tend to average around $572, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to Mexico City from Santiago during March instead. Flights to Mexico City in March, while not as cheap as those in November, still average around $572.

Our data shows that Monday is the least expensive day to fly to Mexico City. Tickets to fly out on this day can be as low as $580. On the other hand, Thursday is the most expensive day to depart from Santiago because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $810.

According to our data, the cheapest time of day to fly to Mexico City is in the evening. momondo users have found flights departing from Santiago to Mexico City in the evening for as low as $654. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the morning is when there is more demand to fly to Mexico City, so prices are often more expensive at around $799 per ticket.

Fly from Santiago Arturo Merino Benitez to Mexico City Benito Juarez for the best Santiago Arturo Merino Benitez - Mexico City Benito Juarez flight prices

You are more likely to see cheaper flights to Mexico City from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Mexico City for around $663 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Mexico City from Santiago for as low as $576 on momondo.

There are 3 cabin classes available to choose from on Santiago to Mexico City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Historically, on average around 13% of flights between Santiago and Mexico City have experienced a delay on any given week. The average delay length over the past 12 months has been 144 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the morning have, in the past, seen delays more frequently in comparison.

Friday is statistically the day of the week which experiences the fewest number of delays on this flight route. Thursday has historically seen more delays on average compared to the rest of the week.

According to our data, Aeromexico have had the least number of delays on this route over the last 12 months; with about 9% of their flights experiencing any sort of delay.

Panama City (PTY) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Flights via Panama City (PTY) offer the lowest average round-trip price of $663.

Flights connecting via Panama City (PTY) have the shortest average one-way travel time: 11h 44m.

Panama City (PTY) has the shortest average layover time for this route: 1h 13m.

As of July 2026, there are 1 flights per day flying from Santiago to Mexico City. The most common time of day flights depart is 8:00AM, with 100% of flights taking off at noon.

As of July 2026, there are 7 flights per week flying from Santiago to Mexico City. The most common day of the week flights depart is Mon, with 14% of flights taking off on this day.