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Cheap flights from Santiago to Guayaquil from $162

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Guayaquil departing on 9/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Copa Airlines Logo
5:12 am - 1:34 pmSCL-GYE
10h 22m1 stop
Copa Airlines Logo
12:20 pm - 12:32 amGYE-SCL
10h 12m1 stop
$340Copa Airlines
Find Deal
Fri, Nov 28 - Fri, Jan 9
Copa Airlines Logo
3:23 am - 11:18 amSCL-GYE
9h 55m1 stop
Copa Airlines Logo
12:20 pm - 11:43 pmGYE-SCL
9h 23m1 stop
$382Copa Airlines
Find Deal
Thu, Nov 27 - Fri, Jan 9
Copa Airlines Logo
4:47 am - 1:46 pmSCL-GYE
10h 59m1 stop
Copa Airlines Logo
8:30 am - 8:20 pmGYE-SCL
9h 50m1 stop
$390Copa Airlines
Find Deal
Wed, Oct 22 - Wed, Oct 29
Copa Airlines Logo
5:12 am - 11:55 pmSCL-GYE
20h 43m1 stop
Copa Airlines Logo
4:33 am - 12:32 amGYE-SCL
17h 59m1 stop
$401Copa Airlines
Find Deal
Fri, Nov 28 - Thu, Jan 8
LATAM Airlines Logo
12:45 am - 4:03 amSCL-GYE
5h 18mnonstop
LATAM Airlines Logo
8:40 pm - 5:50 amGYE-SCL
7h 10m1 stop
$419LATAM Airlines
Find Deal
Wed, Nov 5 - Tue, Nov 11
LATAM Airlines Logo
12:45 am - 4:03 amSCL-GYE
5h 18mnonstop
LATAM Airlines Logo
4:48 pm - 11:35 pmGYE-SCL
4h 47mnonstop
$420LATAM Airlines
Find Deal
Sat, Nov 8 - Thu, Nov 13
Avianca Logo
1:35 am - 4:15 pmSCL-GYE
16h 40m2 stops
Avianca Logo
4:40 am - 12:30 amGYE-SCL
17h 50m1 stop
$431Avianca
Find Deal
Wed, Nov 5 - Mon, Nov 10
Avianca Logo
1:35 am - 2:30 pmSCL-GYE
14h 55m1 stop
Avianca Logo
4:40 am - 12:30 amGYE-SCL
17h 50m1 stop
$438Avianca
Find Deal
Wed, Nov 5 - Mon, Nov 10
Multiple Airlines Logo
12:45 am - 4:03 amSCL-GYE
5h 18mnonstop
Multiple Airlines Logo
3:30 am - 12:30 amGYE-SCL
19h 00m1 stop
$481Multiple Airlines
Find Deal
Wed, Nov 5 - Mon, Nov 10
Multiple Airlines Logo
10:15 pm - 11:55 amSCL-GYE
15h 40m1 stop
Multiple Airlines Logo
3:30 am - 12:30 amGYE-SCL
19h 00m1 stop
$497Multiple Airlines
Find Deal
Thu, Nov 6 - Mon, Nov 10

LATAM Airlines flights from Santiago to Guayaquil

Our best LATAM Airlines deals on Santiago to Guayaquil flight tickets
LATAM Airlines
Nov 5
SCL12:45 amSantiago Arturo Merino Benitez
5h 18m
GYE4:03 amGuayaquil Jose Joaquin de Olmedo
Nov 11
GYE8:40 pmGuayaquil Jose Joaquin de Olmedo
7h 10m
1 stop
SCL5:50 amSantiago Arturo Merino Benitez
$419
Find similar
LATAM Airlines
Nov 8
SCL12:45 amSantiago Arturo Merino Benitez
5h 18m
GYE4:03 amGuayaquil Jose Joaquin de Olmedo
Nov 13
GYE4:48 pmGuayaquil Jose Joaquin de Olmedo
4h 47m
SCL11:35 pmSantiago Arturo Merino Benitez
$420
Find similar
LATAM Airlines
Nov 8
SCL4:35 amSantiago Arturo Merino Benitez
9h 20m
1 stop
GYE11:55 amGuayaquil Jose Joaquin de Olmedo
Nov 13
GYE1:00 pmGuayaquil Jose Joaquin de Olmedo
23h 36m
2 stops
SCL2:36 pmSantiago Arturo Merino Benitez
$421
Find similar

Avianca flights from Santiago to Guayaquil

Our best Avianca deals on Santiago to Guayaquil flight tickets
Avianca
Nov 5
SCL1:35 amSantiago Arturo Merino Benitez
16h 40m
2 stops
GYE4:15 pmGuayaquil Jose Joaquin de Olmedo
Nov 10
GYE4:40 amGuayaquil Jose Joaquin de Olmedo
17h 50m
1 stop
SCL12:30 amSantiago Arturo Merino Benitez
$431
Find similar
Avianca
Nov 5
SCL1:35 amSantiago Arturo Merino Benitez
14h 55m
1 stop
GYE2:30 pmGuayaquil Jose Joaquin de Olmedo
Nov 10
GYE4:40 amGuayaquil Jose Joaquin de Olmedo
17h 50m
1 stop
SCL12:30 amSantiago Arturo Merino Benitez
$438
Find similar
Avianca
Nov 5
SCL1:35 amSantiago Arturo Merino Benitez
16h 40m
2 stops
GYE4:15 pmGuayaquil Jose Joaquin de Olmedo
Nov 10
GYE3:30 amGuayaquil Jose Joaquin de Olmedo
9h 50m
1 stop
SCL3:20 pmSantiago Arturo Merino Benitez
$461
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 11/28

5:12 am-1:34 pm

1 stop10h 22m

Guayaquil Jose Joaquin de Olmedo

Fri 1/9

12:20 pm-12:32 am

1 stop10h 12m

$340

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 11/27

3:23 am-11:18 am

1 stop9h 55m

Guayaquil Jose Joaquin de Olmedo

Fri 1/9

12:20 pm-11:43 pm

1 stop9h 23m

$382

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 10/22

4:47 am-1:46 pm

1 stop10h 59m

Guayaquil Jose Joaquin de Olmedo

Wed 10/29

8:30 am-8:20 pm

1 stop9h 50m

$390

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 11/28

5:12 am-11:55 pm

1 stop20h 43m

Guayaquil Jose Joaquin de Olmedo

Thu 1/8

4:33 am-12:32 am

1 stop17h 59m

$401

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 11/5

12:45 am-4:03 am

Nonstop5h 18m

Guayaquil Jose Joaquin de Olmedo

Tue 11/11

8:40 pm-5:50 am

1 stop7h 10m

$419

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sat 11/8

12:45 am-4:03 am

Nonstop5h 18m

Guayaquil Jose Joaquin de Olmedo

Thu 11/13

4:48 pm-11:35 pm

Nonstop4h 47m

$420

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 11/5

1:35 am-4:15 pm

2 stops16h 40m

Guayaquil Jose Joaquin de Olmedo

Mon 11/10

4:40 am-12:30 am

1 stop17h 50m

$431

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 11/5

1:35 am-2:30 pm

1 stop14h 55m

Guayaquil Jose Joaquin de Olmedo

Mon 11/10

4:40 am-12:30 am

1 stop17h 50m

$438

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 11/5

12:45 am-4:03 am

Nonstop5h 18m

Guayaquil Jose Joaquin de Olmedo

Mon 11/10

3:30 am-12:30 am

1 stop19h 00m

$481

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 11/6

10:15 pm-11:55 am

1 stop15h 40m

Guayaquil Jose Joaquin de Olmedo

Mon 11/10

3:30 am-12:30 am

1 stop19h 00m

$497

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Guayaquil from

How to get the cheapest flight ticket from Santiago to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santiago and Guayaquil?

What is the cheapest month to fly to Guayaquil?

The month of October is another great option to travel to Guayaquil, with average flight prices from Santiago averaging around $377.

What is the cheapest day to depart on your flight to Guayaquil?

The cheapest day to depart from Santiago to Guayaquil is on a Monday. Travelers who choose to depart for Guayaquil on a Monday will often find tickets for as low as $308. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Guayaquil on Sunday is $602.

What is the cheapest time of day to depart on your flight to Guayaquil?

The cheapest time of day to fly to Guayaquil is in the morning when flights can be purchased for as low as $423. Flights to Guayaquil are more costly in the evening, with an average ticket price of $469. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flight route?

Fly from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo for the best Santiago Arturo Merino Benitez - Guayaquil Jose Joaquin de Olmedo flight prices

How far in advance should I book a flight to Guayaquil?

You are more likely to see cheaper flights to Guayaquil from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Guayaquil for around $419 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Guayaquil from Santiago for as low as $343 on momondo.

What cabin class options are available on Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flights?

There is only 1 cabin class available to choose from on Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santiago to Guayaquil flights?

You could potentially save up to 20% on your flight if you consider stops on a Santiago to Guayaquil flight.

How have Santiago to Guayaquil flight prices changed over time?

As of September 2025, prices for Santiago to Guayaquil flights are approximately 7% cheaper when compared to flights at the same time last year.

When to book flights from Santiago to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Guayaquil (SCL to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Guayaquil

Best Price Found

$204

Fastest flight time

5h 18m

Direct flights

Mon, Tue, Thu, Fri, Sat and Sun

Airports in Guayaquil

1 airport
The best one-way flight to Guayaquil from Santiago in the past 72 hours is $204. The best round-trip flight deal from Santiago to Guayaquil found on momondo in the last 72 hours is $197.
The fastest flight from Santiago to Guayaquil takes 5h 18m
Direct flights go from Santiago to Guayaquil on Monday, Tuesday, Thursday, Friday, Saturday and Sunday. The only airline offering direct flights is LATAM Airlines.
There is 1 airport near Guayaquil: Guayaquil Jose Joaquin de Olmedo (GYE)
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  • How far is Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo by plane?

    The distance between Santiago Arturo Merino Benitez and Guayaquil Jose Joaquin de Olmedo is about 2238.9 mi. In terms of flight time, this usually takes a little over 5h 18m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport were last updated today.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The required travel and health documents for your Guayaquil Jose Joaquin de Olmedo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Guayaquil Jose Joaquin de Olmedo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Santiago to Guayaquil?

  • What is the most popular airline from Santiago to Guayaquil?

Best airlines flying from Santiago to Guayaquil

Compare and see reviews for airlines that fly from Santiago to Guayaquil with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $316Free CancellationRating
7.5
1,849 reviews
Search LATAM Airlines flights

  • LATAM Airlines Flights From Santiago to Guayaquil

    The lowest priced LATAM Airlines flight from Santiago to Guayaquil from the last 72 hours was $316. Generally, LATAM Airlines has 3 flights on this route every week with an average price of $473. LATAM Airlines is rated 7.5/10 by our users.

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Guayaquil?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to Guayaquil. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to Guayaquil with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Guayaquil from Santiago with this policy.

How can momondo help me find flights from Santiago to Guayaquil?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Santiago to Guayaquil.

I’m not ready to book a flight from Santiago to Guayaquil right now. Can momondo alert me if prices change?

Price alerts on flights to Guayaquil from Santiago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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