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Cheap flights from Santiago to Guayaquil from $209

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Guayaquil departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
LATAM Airlines Logo
6:45 pm - 1:40 am
SCL
-
GYE
7h 55m1 stop
LATAM Airlines Logo
9:05 am - 9:55 pm
GYE
-
SCL
11h 50m1 stop
$415LATAM Airlines
Thu, Apr 9 - Sun, Apr 12
LATAM Airlines Logo
6:40 pm - 1:40 am
SCL
-
GYE
8h 00m1 stop
LATAM Airlines Logo
8:45 pm - 5:45 am
GYE
-
SCL
8h 00m1 stop
$419LATAM Airlines
Thu, Apr 9 - Sun, Apr 12
Copa Airlines Logo
4:09 am - 1:33 pm
SCL
-
GYE
10h 24m1 stop
Copa Airlines Logo
12:21 pm - 3:00 am
GYE
-
SCL
13h 39m1 stop
$422Copa Airlines
Fri, May 29 - Wed, Jun 17
Copa Airlines Logo
5:12 am - 1:34 pm
SCL
-
GYE
10h 22m1 stop
Copa Airlines Logo
8:34 am - 6:00 am
GYE
-
SCL
19h 26m1 stop
$463Copa Airlines
Tue, Dec 30 - Sat, Jan 10
Copa Airlines Logo
1:08 am - 5:36 pm
SCL
-
GYE
18h 28m1 stop
Copa Airlines Logo
2:35 pm - 3:17 am
GYE
-
SCL
10h 42m1 stop
$467Copa Airlines
Fri, Dec 26 - Tue, Jan 6
LATAM Airlines Logo
12:45 am - 4:03 am
SCL
-
GYE
5h 18mnonstop
LATAM Airlines Logo
8:40 pm - 3:30 pm
GYE
-
SCL
16h 50m1 stop
$480LATAM Airlines
Sat, Feb 28 - Sun, Mar 15
LATAM Airlines Logo
12:45 am - 4:03 am
SCL
-
GYE
5h 18mnonstop
LATAM Airlines Logo
8:40 pm - 6:25 am
GYE
-
SCL
7h 45m1 stop
$483LATAM Airlines
Mon, Feb 9 - Tue, Feb 24
LATAM Airlines Logo
12:45 am - 4:03 am
SCL
-
GYE
5h 18mnonstop
LATAM Airlines Logo
5:08 pm - 11:55 pm
GYE
-
SCL
4h 47mnonstop
$485LATAM Airlines
Sat, Feb 28 - Sun, Mar 15
LATAM Airlines Logo
12:45 am - 5:03 am
SCL
-
GYE
5h 18mnonstop
LATAM Airlines Logo
5:45 pm - 11:36 pm
GYE
-
SCL
4h 51mnonstop
$487LATAM Airlines
Wed, Apr 8 - Sun, Apr 12
LATAM Airlines Logo
7:45 pm - 7:03 am
SCL
-
GYE
12h 18m2 stops
LATAM Airlines Logo
7:31 am - 9:55 pm
GYE
-
SCL
13h 24m2 stops
$488LATAM Airlines
Thu, Apr 9 - Sun, Apr 12

Copa Airlines flights from Santiago to Guayaquil

Our best Copa Airlines deals on Santiago to Guayaquil flight tickets
Copa Airlines
Dec 24
SCL5:12 amSantiago Arturo Merino Benitez
10h 22m
1 stop
GYE1:34 pmGuayaquil Jose Joaquin de Olmedo
Jan 3
GYE4:33 amGuayaquil Jose Joaquin de Olmedo
17h 59m
1 stop
SCL12:32 amSantiago Arturo Merino Benitez
$430
Find similar
Copa Airlines
Dec 24
SCL5:12 amSantiago Arturo Merino Benitez
10h 22m
1 stop
GYE1:34 pmGuayaquil Jose Joaquin de Olmedo
Jan 12
GYE12:20 pmGuayaquil Jose Joaquin de Olmedo
10h 12m
1 stop
SCL12:32 amSantiago Arturo Merino Benitez
$446
Find similar
Copa Airlines
Dec 25
SCL5:12 amSantiago Arturo Merino Benitez
17h 31m
1 stop
GYE8:43 pmGuayaquil Jose Joaquin de Olmedo
Jan 10
GYE8:34 amGuayaquil Jose Joaquin de Olmedo
19h 26m
1 stop
SCL6:00 amSantiago Arturo Merino Benitez
$450
Find similar

Avianca flights from Santiago to Guayaquil

Our best Avianca deals on Santiago to Guayaquil flight tickets
Avianca
Dec 26
SCL7:25 amSantiago Arturo Merino Benitez
12h 20m
1 stop
GYE5:45 pmGuayaquil Jose Joaquin de Olmedo
Jan 27
GYE3:30 amGuayaquil Jose Joaquin de Olmedo
9h 50m
1 stop
SCL3:20 pmSantiago Arturo Merino Benitez
$518
Find similar
Avianca
Dec 29
SCL1:35 amSantiago Arturo Merino Benitez
11h 50m
2 stops
GYE11:25 amGuayaquil Jose Joaquin de Olmedo
Jan 27
GYE3:30 amGuayaquil Jose Joaquin de Olmedo
9h 50m
1 stop
SCL3:20 pmSantiago Arturo Merino Benitez
$578
Find similar
Avianca
Jan 8
SCL1:35 amSantiago Arturo Merino Benitez
11h 50m
2 stops
GYE11:25 amGuayaquil Jose Joaquin de Olmedo
Jan 12
GYE6:30 amGuayaquil Jose Joaquin de Olmedo
16h 00m
2 stops
SCL12:30 amSantiago Arturo Merino Benitez
$586
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 4/9

6:45 pm-1:40 am

1 stop7h 55m

Guayaquil Jose Joaquin de Olmedo

Sun 4/12

9:05 am-9:55 pm

1 stop11h 50m

$415

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 4/9

6:40 pm-1:40 am

1 stop8h 00m

Guayaquil Jose Joaquin de Olmedo

Sun 4/12

8:45 pm-5:45 am

1 stop8h 00m

$419

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 5/29

4:09 am-1:33 pm

1 stop10h 24m

Guayaquil Jose Joaquin de Olmedo

Wed 6/17

12:21 pm-3:00 am

1 stop13h 39m

$422

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Tue 12/30

5:12 am-1:34 pm

1 stop10h 22m

Guayaquil Jose Joaquin de Olmedo

Sat 1/10

8:34 am-6:00 am

1 stop19h 26m

$463

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 12/26

1:08 am-5:36 pm

1 stop18h 28m

Guayaquil Jose Joaquin de Olmedo

Tue 1/6

2:35 pm-3:17 am

1 stop10h 42m

$467

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sat 2/28

12:45 am-4:03 am

Nonstop5h 18m

Guayaquil Jose Joaquin de Olmedo

Sun 3/15

8:40 pm-3:30 pm

1 stop16h 50m

$480

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 2/9

12:45 am-4:03 am

Nonstop5h 18m

Guayaquil Jose Joaquin de Olmedo

Tue 2/24

8:40 pm-6:25 am

1 stop7h 45m

$483

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sat 2/28

12:45 am-4:03 am

Nonstop5h 18m

Guayaquil Jose Joaquin de Olmedo

Sun 3/15

5:08 pm-11:55 pm

Nonstop4h 47m

$485

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 4/8

12:45 am-5:03 am

Nonstop5h 18m

Guayaquil Jose Joaquin de Olmedo

Sun 4/12

5:45 pm-11:36 pm

Nonstop4h 51m

$487

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 4/9

7:45 pm-7:03 am

2 stops12h 18m

Guayaquil Jose Joaquin de Olmedo

Sun 4/12

7:31 am-9:55 pm

2 stops13h 24m

$488

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Guayaquil from

How to get the cheapest flight ticket from Santiago to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Guayaquil?

The month of April is another great option to travel to Guayaquil, with average flight prices from Santiago averaging around $413.

What is the cheapest day to depart on your flight to Guayaquil?

The cheapest day to depart from Santiago to Guayaquil is on a Saturday. Travelers who choose to depart for Guayaquil on a Saturday will often find tickets for as low as $234. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Guayaquil on Sunday is $563.

What is the cheapest time of day to depart on your flight to Guayaquil?

The cheapest time of day to fly to Guayaquil is in the morning when flights can be purchased for as low as $423. Flights to Guayaquil are more costly in the evening, with an average ticket price of $472. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flight route?

Fly from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo for the best Santiago Arturo Merino Benitez - Guayaquil Jose Joaquin de Olmedo flight prices

How far in advance should I book a flight to Guayaquil?

You are more likely to see cheaper flights to Guayaquil from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Guayaquil for around $440 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Guayaquil from Santiago for as low as $387 on momondo.

What cabin class options are available on Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flights?

There is only 1 cabin class available to choose from on Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santiago to Guayaquil flights?

No. A direct flight is the cheapest option for a flight between Santiago to Guayaquil.

How have Santiago to Guayaquil flight prices changed over time?

As of December 2025, prices for Santiago to Guayaquil flights are approximately 2% more expensive when compared to flights at the same time last year.

When to book flights from Santiago to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Guayaquil (SCL to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Guayaquil

Fastest flight time

9h 10m

Direct flights

Mon, Tue, Wed, Thu, Fri and Sun

Airports in Guayaquil

1 airport
The fastest flight from Santiago to Guayaquil takes 9h 10m
Direct flights go from Santiago to Guayaquil on Monday, Tuesday, Wednesday, Thursday, Friday and Sunday. There are no airlines offering direct flights.
There is 1 airport in Guayaquil. From Santiago there are direct flights to Guayaquil Jose Joaquin de Olmedo (GYE).
Search flight deals

  • How far is Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo by plane?

    The distance between Santiago Arturo Merino Benitez and Guayaquil Jose Joaquin de Olmedo is about 2238.9 mi. In terms of flight time, this usually takes a little over 9h 10m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport were last updated today.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The required travel and health documents for your Guayaquil Jose Joaquin de Olmedo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Guayaquil Jose Joaquin de Olmedo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Santiago to Guayaquil?

  • What is the most popular airline from Santiago to Guayaquil?

Best airlines flying from Santiago to Guayaquil

Compare and see reviews for airlines that fly from Santiago to Guayaquil with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $320Free CancellationRating
7.5
1,893 reviews
Search LATAM Airlines flights

  • LATAM Airlines Flights From Santiago to Guayaquil

    The lowest priced LATAM Airlines flight from Santiago to Guayaquil from the last 72 hours was $320. Generally, LATAM Airlines has 7 flights on this route every week with an average price of $477. LATAM Airlines is rated 7.5/10 by our users.

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Guayaquil?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to Guayaquil. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to Guayaquil with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Guayaquil from Santiago with this policy.

How can momondo help me find flights from Santiago to Guayaquil?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Santiago to Guayaquil.

I’m not ready to book a flight from Santiago to Guayaquil right now. Can momondo alert me if prices change?

Price alerts on flights to Guayaquil from Santiago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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