Cheap flights from Santiago to Guayaquil from $208

The month of August is another great option to travel to Guayaquil, with average flight prices from Santiago averaging around $419.

The cheapest day to depart from Santiago to Guayaquil is on a Saturday. Travelers who choose to depart for Guayaquil on a Saturday will often find tickets for as low as $234. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Guayaquil on Sunday is $565.

Fly from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo for the best Santiago Arturo Merino Benitez - Guayaquil Jose Joaquin de Olmedo flight prices

You are more likely to see cheaper flights to Guayaquil from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Guayaquil for around $450 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Guayaquil from Santiago for as low as $396 on momondo.

There are 2 cabin classes available to choose from on Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Santiago to Guayaquil.

Historically, on average around 6% of flights between Santiago and Guayaquil have experienced a delay on any given week. The average delay length over the past 12 months has been 160 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights at night have, in the past, seen delays more frequently in comparison.

Thursday is statistically the day of the week which experiences the fewest number of delays on this flight route. Monday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the least number of delays on this route over the last 12 months; with about 6% of their flights experiencing any sort of delay.

Bogotá (BOG) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Flights via Bogotá (BOG) offer the lowest average round-trip price of $291.

Flights connecting via Lima (LIM) have the shortest average one-way travel time: 8h 30m.

Lima (LIM) has the shortest average layover time for this route: 2h 25m.

1 flights are operational daily from Santiago to Guayaquil as of February 2026. The most popular departure time for this route is 12:00AM, with 100% of flights per day taking off in the morning.

As of February 2026, 7 flights take off from Santiago and land in Guayaquil each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.