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Cheap flights from Santiago to Guayaquil from $148

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Guayaquil departing on 8/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

LATAM Airlines Logo
4:35 am - 11:55 amSCL-GYE
9h 20m1 stop
LATAM Airlines Logo
1:00 pm - 11:25 pmGYE-SCL
8h 25m1 stop
$310LATAM Airlines
Find Deal
Wed, Nov 5 - Tue, Nov 11
LATAM Airlines Logo
5:35 am - 2:10 pmSCL-GYE
9h 35m1 stop
LATAM Airlines Logo
12:55 pm - 10:50 pmGYE-SCL
7h 55m1 stop
$317LATAM Airlines
Find Deal
Fri, Sep 5 - Wed, Sep 10
Copa Airlines Logo
12:13 am - 1:46 pmSCL-GYE
14h 33m1 stop
Copa Airlines Logo
4:27 am - 11:04 pmGYE-SCL
17h 37m1 stop
$319Copa Airlines
Find Deal
Tue, Aug 26 - Wed, Sep 3
LATAM Airlines Logo
7:10 am - 2:10 pmSCL-GYE
8h 00m1 stop
LATAM Airlines Logo
12:55 pm - 9:41 amGYE-SCL
18h 46m2 stops
$325LATAM Airlines
Find Deal
Fri, Sep 5 - Wed, Sep 10
LATAM Airlines Logo
10:40 pm - 5:23 pmSCL-GYE
20h 43m2 stops
LATAM Airlines Logo
12:55 pm - 9:55 pmGYE-SCL
7h 00m1 stop
$331LATAM Airlines
Find Deal
Sun, Sep 7 - Tue, Sep 9
Copa Airlines Logo
12:24 am - 11:15 amSCL-GYE
11h 51m1 stop
Copa Airlines Logo
2:47 pm - 3:42 amGYE-SCL
10h 55m1 stop
$340Copa Airlines
Find Deal
Sun, Aug 17 - Fri, Sep 12
Avianca Logo
11:55 pm - 1:40 pmSCL-GYE
14h 45m1 stop
Avianca Logo
3:35 am - 1:25 pmGYE-SCL
8h 50m1 stop
$397Avianca
Find Deal
Sun, Aug 17 - Mon, Aug 25
Avianca Logo
2:30 pm - 10:40 pmSCL-GYE
9h 10m1 stop
Avianca Logo
6:25 pm - 5:15 amGYE-SCL
8h 50m1 stop
$398Avianca
Find Deal
Fri, Aug 29 - Fri, Sep 12
Logo
12:24 am - 1:46 pmSCL-GYE
14h 22m1 stop
Logo
2:45 pm - 9:38 pmGYE-SCL
4h 53mnonstop
$428
Find Deal
Thu, Sep 4 - Thu, Sep 11
Logo
12:24 am - 11:15 amSCL-GYE
11h 51m1 stop
Logo
4:18 pm - 11:11 pmGYE-SCL
4h 53mnonstop
$444
Find Deal
Thu, Sep 4 - Sat, Sep 13

Copa Airlines flights from Santiago to Guayaquil

Our best Copa Airlines deals on Santiago to Guayaquil flight tickets
Copa Airlines
Aug 26
SCL12:13 amSantiago Arturo Merino Benitez
14h 33m
1 stop
GYE1:46 pmGuayaquil Jose Joaquin de Olmedo
Sep 3
GYE4:27 amGuayaquil Jose Joaquin de Olmedo
17h 37m
1 stop
SCL11:04 pmSantiago Arturo Merino Benitez
$319
Find similar
Copa Airlines
Aug 17
SCL12:24 amSantiago Arturo Merino Benitez
11h 51m
1 stop
GYE11:15 amGuayaquil Jose Joaquin de Olmedo
Sep 12
GYE2:47 pmGuayaquil Jose Joaquin de Olmedo
10h 55m
1 stop
SCL3:42 amSantiago Arturo Merino Benitez
$340
Find similar
Copa Airlines
Oct 4
SCL12:29 pmSantiago Arturo Merino Benitez
13h 24m
1 stop
GYE11:53 pmGuayaquil Jose Joaquin de Olmedo
Jan 3
GYE12:20 pmGuayaquil Jose Joaquin de Olmedo
9h 54m
1 stop
SCL12:14 amSantiago Arturo Merino Benitez
$359
Find similar

LATAM Airlines flights from Santiago to Guayaquil

Our best LATAM Airlines deals on Santiago to Guayaquil flight tickets
LATAM Airlines
Nov 5
SCL4:35 amSantiago Arturo Merino Benitez
9h 20m
1 stop
GYE11:55 amGuayaquil Jose Joaquin de Olmedo
Nov 11
GYE1:00 pmGuayaquil Jose Joaquin de Olmedo
8h 25m
1 stop
SCL11:25 pmSantiago Arturo Merino Benitez
$310
Find similar
LATAM Airlines
Sep 5
SCL5:35 amSantiago Arturo Merino Benitez
9h 35m
1 stop
GYE2:10 pmGuayaquil Jose Joaquin de Olmedo
Sep 10
GYE12:55 pmGuayaquil Jose Joaquin de Olmedo
7h 55m
1 stop
SCL10:50 pmSantiago Arturo Merino Benitez
$317
Find similar
LATAM Airlines
Sep 5
SCL7:10 amSantiago Arturo Merino Benitez
8h 00m
1 stop
GYE2:10 pmGuayaquil Jose Joaquin de Olmedo
Sep 10
GYE12:55 pmGuayaquil Jose Joaquin de Olmedo
18h 46m
2 stops
SCL9:41 amSantiago Arturo Merino Benitez
$325
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 1, 2025.
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 11/5

4:35 am-11:55 am

1 stop9h 20m

Guayaquil Jose Joaquin de Olmedo

Tue 11/11

1:00 pm-11:25 pm

1 stop8h 25m

$310

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 9/5

5:35 am-2:10 pm

1 stop9h 35m

Guayaquil Jose Joaquin de Olmedo

Wed 9/10

12:55 pm-10:50 pm

1 stop7h 55m

$317

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Tue 8/26

12:13 am-1:46 pm

1 stop14h 33m

Guayaquil Jose Joaquin de Olmedo

Wed 9/3

4:27 am-11:04 pm

1 stop17h 37m

$319

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 9/5

7:10 am-2:10 pm

1 stop8h 00m

Guayaquil Jose Joaquin de Olmedo

Wed 9/10

12:55 pm-9:41 am

2 stops18h 46m

$325

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sun 9/7

10:40 pm-5:23 pm

2 stops20h 43m

Guayaquil Jose Joaquin de Olmedo

Tue 9/9

12:55 pm-9:55 pm

1 stop7h 00m

$331

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sun 8/17

12:24 am-11:15 am

1 stop11h 51m

Guayaquil Jose Joaquin de Olmedo

Fri 9/12

2:47 pm-3:42 am

1 stop10h 55m

$340

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sun 8/17

11:55 pm-1:40 pm

1 stop14h 45m

Guayaquil Jose Joaquin de Olmedo

Mon 8/25

3:35 am-1:25 pm

1 stop8h 50m

$397

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 8/29

2:30 pm-10:40 pm

1 stop9h 10m

Guayaquil Jose Joaquin de Olmedo

Fri 9/12

6:25 pm-5:15 am

1 stop8h 50m

$398

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 9/4

12:24 am-1:46 pm

1 stop14h 22m

Guayaquil Jose Joaquin de Olmedo

Thu 9/11

2:45 pm-9:38 pm

Nonstop4h 53m

$428

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 9/4

12:24 am-11:15 am

1 stop11h 51m

Guayaquil Jose Joaquin de Olmedo

Sat 9/13

4:18 pm-11:11 pm

Nonstop4h 53m

$444

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Guayaquil from

How to get the cheapest flight ticket from Santiago to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Guayaquil?

The month of October is another great option to travel to Guayaquil, with average flight prices from Santiago averaging around $365.

What is the cheapest day to depart on your flight to Guayaquil?

The cheapest day to depart from Santiago to Guayaquil is on a Monday. Travelers who choose to depart for Guayaquil on a Monday will often find tickets for as low as $313. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Guayaquil on Sunday is $602.

What is the cheapest time of day to depart on your flight to Guayaquil?

The cheapest time of day to fly to Guayaquil is in the morning when flights can be purchased for as low as $423. Flights to Guayaquil are more costly in the evening, with an average ticket price of $472. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flight route?

Fly from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo for the best Santiago Arturo Merino Benitez - Guayaquil Jose Joaquin de Olmedo flight prices

How far in advance should I book a flight to Guayaquil?

You are more likely to see cheaper flights to Guayaquil from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Guayaquil for around $409 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Guayaquil from Santiago for as low as $339 on momondo.

What cabin class options are available on Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flights?

There are 2 cabin classes available to choose from on Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santiago to Guayaquil flights?

You could potentially save up to 15% on your flight if you consider stops on a Santiago to Guayaquil flight.

How have Santiago to Guayaquil flight prices changed over time?

As of August 2025, prices for Santiago to Guayaquil flights are approximately 18% cheaper when compared to flights at the same time last year.

When to book flights from Santiago to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Guayaquil (SCL to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Guayaquil

Best Price Found

$148

Fastest flight time

5h 18m

Direct flights

Mon, Tue, Thu, Fri, Sat and Sun

Airports in Guayaquil

1 airport
The best one-way flight to Guayaquil from Santiago in the past 72 hours is $148. The best round-trip flight deal from Santiago to Guayaquil found on momondo in the last 72 hours is $310.
The fastest flight from Santiago to Guayaquil takes 5h 18m
Direct flights go from Santiago to Guayaquil on Monday, Tuesday, Thursday, Friday, Saturday and Sunday. The only airline offering direct flights is LATAM Airlines.
There is 1 airport near Guayaquil: Guayaquil Jose Joaquin de Olmedo (GYE)
Search flight deals

  • How far is Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo by plane?

    The distance between Santiago Arturo Merino Benitez and Guayaquil Jose Joaquin de Olmedo is about 2238.9 mi. In terms of flight time, this usually takes a little over 5h 18m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport were last updated today.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The required travel and health documents for your Guayaquil Jose Joaquin de Olmedo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Guayaquil Jose Joaquin de Olmedo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Santiago to Guayaquil?

  • What is the most popular airline from Santiago to Guayaquil?

Best airlines flying from Santiago to Guayaquil

Compare and see reviews for airlines that fly from Santiago to Guayaquil with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $313Free CancellationRating
7.5
1,823 reviews
Search LATAM Airlines flights

  • LATAM Airlines Flights From Santiago to Guayaquil

    The lowest priced LATAM Airlines flight from Santiago to Guayaquil from the last 72 hours was $313. Generally, LATAM Airlines has 6 flights on this route every week with an average price of $470. LATAM Airlines is rated 7.5/10 by our users.

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Guayaquil?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to Guayaquil. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to Guayaquil with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Guayaquil from Santiago with this policy.

How can momondo help me find flights from Santiago to Guayaquil?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Santiago to Guayaquil.

I’m not ready to book a flight from Santiago to Guayaquil right now. Can momondo alert me if prices change?

Price alerts on flights to Guayaquil from Santiago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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