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Cheap flights from Santiago to Guayaquil from $193

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Guayaquil departing on 11/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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LATAM Airlines Logo
8:15 am - 2:45 pmSCL-GYE
8h 30m1 stop
LATAM Airlines Logo
8:40 pm - 11:05 amGYE-SCL
12h 25m2 stops
$419LATAM Airlines
Find Deal
Mon, Dec 8 - Wed, Dec 10
LATAM Airlines Logo
10:30 am - 1:40 amSCL-GYE
17h 10m2 stops
LATAM Airlines Logo
9:05 am - 9:55 pmGYE-SCL
10h 50m1 stop
$421LATAM Airlines
Find Deal
Fri, Dec 12 - Fri, Dec 19
Copa Airlines Logo
3:23 am - 11:18 amSCL-GYE
9h 55m1 stop
Copa Airlines Logo
12:21 pm - 12:06 amGYE-SCL
9h 45m1 stop
$422Copa Airlines
Find Deal
Thu, Nov 13 - Fri, Nov 21
LATAM Airlines Logo
4:35 am - 2:45 pmSCL-GYE
12h 10m1 stop
LATAM Airlines Logo
8:40 pm - 11:05 amGYE-SCL
12h 25m2 stops
$428LATAM Airlines
Find Deal
Sun, Dec 7 - Wed, Dec 10
LATAM Airlines Logo
8:15 am - 2:45 pmSCL-GYE
8h 30m1 stop
LATAM Airlines Logo
4:48 pm - 11:35 pmGYE-SCL
4h 47mnonstop
$429LATAM Airlines
Find Deal
Mon, Dec 8 - Wed, Dec 10
Copa Airlines Logo
3:23 am - 1:36 pmSCL-GYE
12h 13m1 stop
Copa Airlines Logo
12:21 pm - 3:43 amGYE-SCL
13h 22m1 stop
$430Copa Airlines
Find Deal
Tue, Nov 11 - Thu, Nov 27
LATAM Airlines Logo
6:30 pm - 6:53 amSCL-GYE
14h 23m2 stops
LATAM Airlines Logo
8:40 pm - 11:05 amGYE-SCL
12h 25m2 stops
$439LATAM Airlines
Find Deal
Mon, Dec 8 - Wed, Dec 10
LATAM Airlines Logo
4:35 am - 2:45 pmSCL-GYE
12h 10m1 stop
LATAM Airlines Logo
8:40 pm - 3:30 pmGYE-SCL
16h 50m1 stop
$440LATAM Airlines
Find Deal
Sun, Dec 7 - Wed, Dec 10
Multiple Airlines Logo
4:35 am - 2:45 pmSCL-GYE
12h 10m1 stop
Multiple Airlines Logo
3:30 am - 3:20 pmGYE-SCL
9h 50m1 stop
$441Multiple Airlines
Find Deal
Sun, Dec 7 - Tue, Dec 9
Copa Airlines Logo
3:23 am - 1:36 pmSCL-GYE
12h 13m1 stop
Copa Airlines Logo
4:31 am - 12:06 amGYE-SCL
17h 35m1 stop
$442Copa Airlines
Find Deal
Thu, Nov 13 - Sat, Nov 29

LATAM Airlines flights from Santiago to Guayaquil

Our best LATAM Airlines deals on Santiago to Guayaquil flight tickets
LATAM Airlines
Dec 8
SCL8:15 amSantiago Arturo Merino Benitez
8h 30m
1 stop
GYE2:45 pmGuayaquil Jose Joaquin de Olmedo
Dec 10
GYE8:40 pmGuayaquil Jose Joaquin de Olmedo
12h 25m
2 stops
SCL11:05 amSantiago Arturo Merino Benitez
$419
Find similar
LATAM Airlines
Dec 12
SCL10:30 amSantiago Arturo Merino Benitez
17h 10m
2 stops
GYE1:40 amGuayaquil Jose Joaquin de Olmedo
Dec 19
GYE9:05 amGuayaquil Jose Joaquin de Olmedo
10h 50m
1 stop
SCL9:55 pmSantiago Arturo Merino Benitez
$421
Find similar
LATAM Airlines
Dec 7
SCL4:35 amSantiago Arturo Merino Benitez
12h 10m
1 stop
GYE2:45 pmGuayaquil Jose Joaquin de Olmedo
Dec 10
GYE8:40 pmGuayaquil Jose Joaquin de Olmedo
12h 25m
2 stops
SCL11:05 amSantiago Arturo Merino Benitez
$428
Find similar

Copa Airlines flights from Santiago to Guayaquil

Our best Copa Airlines deals on Santiago to Guayaquil flight tickets
Copa Airlines
Nov 8
SCL5:12 amSantiago Arturo Merino Benitez
20h 43m
1 stop
GYE11:55 pmGuayaquil Jose Joaquin de Olmedo
Nov 16
GYE12:21 pmGuayaquil Jose Joaquin de Olmedo
9h 45m
1 stop
SCL12:06 amSantiago Arturo Merino Benitez
$415
Find similar
Copa Airlines
Nov 13
SCL3:23 amSantiago Arturo Merino Benitez
9h 55m
1 stop
GYE11:18 amGuayaquil Jose Joaquin de Olmedo
Nov 21
GYE12:21 pmGuayaquil Jose Joaquin de Olmedo
9h 45m
1 stop
SCL12:06 amSantiago Arturo Merino Benitez
$422
Find similar
Copa Airlines
Nov 11
SCL3:23 amSantiago Arturo Merino Benitez
12h 13m
1 stop
GYE1:36 pmGuayaquil Jose Joaquin de Olmedo
Nov 27
GYE12:21 pmGuayaquil Jose Joaquin de Olmedo
13h 22m
1 stop
SCL3:43 amSantiago Arturo Merino Benitez
$430
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 12/8

8:15 am-2:45 pm

1 stop8h 30m

Guayaquil Jose Joaquin de Olmedo

Wed 12/10

8:40 pm-11:05 am

2 stops12h 25m

$419

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 12/12

10:30 am-1:40 am

2 stops17h 10m

Guayaquil Jose Joaquin de Olmedo

Fri 12/19

9:05 am-9:55 pm

1 stop10h 50m

$421

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 11/13

3:23 am-11:18 am

1 stop9h 55m

Guayaquil Jose Joaquin de Olmedo

Fri 11/21

12:21 pm-12:06 am

1 stop9h 45m

$422

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sun 12/7

4:35 am-2:45 pm

1 stop12h 10m

Guayaquil Jose Joaquin de Olmedo

Wed 12/10

8:40 pm-11:05 am

2 stops12h 25m

$428

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 12/8

8:15 am-2:45 pm

1 stop8h 30m

Guayaquil Jose Joaquin de Olmedo

Wed 12/10

4:48 pm-11:35 pm

Nonstop4h 47m

$429

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Tue 11/11

3:23 am-1:36 pm

1 stop12h 13m

Guayaquil Jose Joaquin de Olmedo

Thu 11/27

12:21 pm-3:43 am

1 stop13h 22m

$430

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 12/8

6:30 pm-6:53 am

2 stops14h 23m

Guayaquil Jose Joaquin de Olmedo

Wed 12/10

8:40 pm-11:05 am

2 stops12h 25m

$439

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sun 12/7

4:35 am-2:45 pm

1 stop12h 10m

Guayaquil Jose Joaquin de Olmedo

Wed 12/10

8:40 pm-3:30 pm

1 stop16h 50m

$440

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Sun 12/7

4:35 am-2:45 pm

1 stop12h 10m

Guayaquil Jose Joaquin de Olmedo

Tue 12/9

3:30 am-3:20 pm

1 stop9h 50m

$441

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 11/13

3:23 am-1:36 pm

1 stop12h 13m

Guayaquil Jose Joaquin de Olmedo

Sat 11/29

4:31 am-12:06 am

1 stop17h 35m

$442

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Guayaquil from

How to get the cheapest flight ticket from Santiago to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Guayaquil?

The month of July is another great option to travel to Guayaquil, with average flight prices from Santiago averaging around $405.

What is the cheapest day to depart on your flight to Guayaquil?

The cheapest day to depart from Santiago to Guayaquil is on a Monday. Travelers who choose to depart for Guayaquil on a Monday will often find tickets for as low as $308. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Guayaquil on Sunday is $602.

What is the cheapest time of day to depart on your flight to Guayaquil?

The cheapest time of day to fly to Guayaquil is in the morning when flights can be purchased for as low as $423. Flights to Guayaquil are more costly in the evening, with an average ticket price of $472. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flight route?

Fly from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo for the best Santiago Arturo Merino Benitez - Guayaquil Jose Joaquin de Olmedo flight prices

How far in advance should I book a flight to Guayaquil?

You are more likely to see cheaper flights to Guayaquil from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Guayaquil for around $431 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Guayaquil from Santiago for as low as $387 on momondo.

What cabin class options are available on Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flights?

There is only 1 cabin class available to choose from on Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Santiago to Guayaquil flight prices changed over time?

As of October 2025, prices for Santiago to Guayaquil flights are approximately 13% cheaper when compared to flights at the same time last year.

When to book flights from Santiago to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Guayaquil (SCL to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Guayaquil

Best Price Found

$204

Fastest flight time

5h 18m

Direct flights

Mon, Tue, Wed, Fri and Sun

Airports in Guayaquil

1 airport
The best one-way flight to Guayaquil from Santiago in the past 72 hours is $204. The best round-trip flight deal from Santiago to Guayaquil found on momondo in the last 72 hours is $425.
The fastest flight from Santiago to Guayaquil takes 5h 18m
Direct flights go from Santiago to Guayaquil on Monday, Tuesday, Wednesday, Friday and Sunday. The only airline offering direct flights is LATAM Airlines.
There is 1 airport near Guayaquil: Guayaquil Jose Joaquin de Olmedo (GYE)
Search flight deals

  • How far is Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo by plane?

    The distance between Santiago Arturo Merino Benitez and Guayaquil Jose Joaquin de Olmedo is about 2238.9 mi. In terms of flight time, this usually takes a little over 5h 18m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport were last updated today.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The required travel and health documents for your Guayaquil Jose Joaquin de Olmedo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Guayaquil Jose Joaquin de Olmedo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Santiago to Guayaquil?

  • What is the most popular airline from Santiago to Guayaquil?

Best airlines flying from Santiago to Guayaquil

Compare and see reviews for airlines that fly from Santiago to Guayaquil with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $316Free CancellationRating
7.5
1,873 reviews
Search LATAM Airlines flights

  • LATAM Airlines Flights From Santiago to Guayaquil

    The lowest priced LATAM Airlines flight from Santiago to Guayaquil from the last 72 hours was $316. Generally, LATAM Airlines has 7 flights on this route every week with an average price of $478. LATAM Airlines is rated 7.5/10 by our users.

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Guayaquil?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to Guayaquil. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to Guayaquil with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Guayaquil from Santiago with this policy.

How can momondo help me find flights from Santiago to Guayaquil?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Santiago to Guayaquil.

I’m not ready to book a flight from Santiago to Guayaquil right now. Can momondo alert me if prices change?

Price alerts on flights to Guayaquil from Santiago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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