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Cheap flights from Santiago to Guayaquil from $240

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Guayaquil departing on 5/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Santiago to Guayaquil

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
6:40 am - 2:35 pm
SCL
-
GYE
8h 55m
1 stop
Avianca Logo
10:05 am - 11:20 pm
GYE
-
SCL
12h 15m
1 stop
$492Avianca
Tue, Apr 21 - Fri, May 15
LATAM Airlines Logo
4:50 pm - 1:40 am
SCL
-
GYE
9h 50m
1 stop
LATAM Airlines Logo
9:05 am - 4:35 pm
GYE
-
SCL
6h 30m
1 stop
$506LATAM Airlines
Mon, May 18 - Sat, May 30
LATAM Airlines Logo
1:30 pm - 1:40 am
SCL
-
GYE
13h 10m
1 stop
LATAM Airlines Logo
9:05 am - 5:25 pm
GYE
-
SCL
7h 20m
1 stop
$507LATAM Airlines
Mon, May 18 - Sat, May 30
LATAM Airlines Logo
6:45 pm - 1:40 am
SCL
-
GYE
7h 55m
1 stop
LATAM Airlines Logo
8:45 pm - 2:05 pm
GYE
-
SCL
16h 20m
1 stop
$509LATAM Airlines
Thu, May 7 - Sun, May 17
LATAM Airlines Logo
6:45 pm - 1:40 am
SCL
-
GYE
7h 55m
1 stop
LATAM Airlines Logo
8:45 pm - 4:50 am
GYE
-
SCL
7h 05m
1 stop
$510LATAM Airlines
Thu, May 21 - Sun, Jun 7
LATAM Airlines Logo
6:45 pm - 1:40 am
SCL
-
GYE
7h 55m
1 stop
LATAM Airlines Logo
4:40 pm - 10:49 am
GYE
-
SCL
17h 09m
2 stops
$512LATAM Airlines
Thu, May 7 - Tue, May 19
LATAM Airlines Logo
4:50 pm - 1:40 am
SCL
-
GYE
9h 50m
1 stop
LATAM Airlines Logo
8:45 pm - 11:50 am
GYE
-
SCL
14h 05m
2 stops
$513LATAM Airlines
Tue, Apr 21 - Fri, May 15
Avianca Logo
6:40 am - 2:35 pm
SCL
-
GYE
8h 55m
1 stop
Avianca Logo
6:50 pm - 2:15 pm
GYE
-
SCL
18h 25m
1 stop
$514Avianca
Fri, Apr 17 - Fri, Apr 17
LATAM Airlines Logo
6:45 pm - 1:40 am
SCL
-
GYE
7h 55m
1 stop
LATAM Airlines Logo
5:38 pm - 11:29 pm
GYE
-
SCL
4h 51mnonstop
$516LATAM Airlines
Thu, May 7 - Tue, May 19
LATAM Airlines Logo
6:52 pm - 2:45 pm
SCL
-
GYE
20h 53m
2 stops
LATAM Airlines Logo
8:45 pm - 4:50 am
GYE
-
SCL
7h 05m
1 stop
$520LATAM Airlines
Fri, May 8 - Sun, May 17

LATAM Airlines flights from Santiago to Guayaquil

Our best LATAM Airlines deals on Santiago to Guayaquil flight tickets
LATAM Airlines
May 18
SCL4:50 pmSantiago Arturo Merino Benitez
9h 50m
1 stop
GYE1:40 amGuayaquil Jose Joaquin de Olmedo
May 30
GYE9:05 amGuayaquil Jose Joaquin de Olmedo
6h 30m
1 stop
SCL4:35 pmSantiago Arturo Merino Benitez
$506
LATAM Airlines
May 18
SCL1:30 pmSantiago Arturo Merino Benitez
13h 10m
1 stop
GYE1:40 amGuayaquil Jose Joaquin de Olmedo
May 30
GYE9:05 amGuayaquil Jose Joaquin de Olmedo
7h 20m
1 stop
SCL5:25 pmSantiago Arturo Merino Benitez
$507
LATAM Airlines
May 7
SCL6:45 pmSantiago Arturo Merino Benitez
7h 55m
1 stop
GYE1:40 amGuayaquil Jose Joaquin de Olmedo
May 17
GYE8:45 pmGuayaquil Jose Joaquin de Olmedo
16h 20m
1 stop
SCL2:05 pmSantiago Arturo Merino Benitez
$509

Copa Airlines flights from Santiago to Guayaquil

Our best Copa Airlines deals on Santiago to Guayaquil flight tickets
Copa Airlines
Apr 7
SCL2:30 amSantiago Arturo Merino Benitez
9h 52m
1 stop
GYE11:22 amGuayaquil Jose Joaquin de Olmedo
Apr 12
GYE6:00 amGuayaquil Jose Joaquin de Olmedo
16h 26m
1 stop
SCL11:26 pmSantiago Arturo Merino Benitez
$522
Copa Airlines
Jun 2
SCL2:22 amSantiago Arturo Merino Benitez
12h 11m
1 stop
GYE1:33 pmGuayaquil Jose Joaquin de Olmedo
Jun 23
GYE8:27 amGuayaquil Jose Joaquin de Olmedo
9h 56m
1 stop
SCL7:23 pmSantiago Arturo Merino Benitez
$534
Copa Airlines
Apr 6
SCL4:17 amSantiago Arturo Merino Benitez
20h 45m
1 stop
GYE12:02 amGuayaquil Jose Joaquin de Olmedo
Apr 13
GYE6:00 amGuayaquil Jose Joaquin de Olmedo
12h 23m
1 stop
SCL7:23 pmSantiago Arturo Merino Benitez
$554

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Tue 4/21

6:40 am-2:35 pm

1 stop8h 55m

Guayaquil Jose Joaquin de Olmedo

Fri 5/15

10:05 am-11:20 pm

1 stop12h 15m

$492

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 5/18

4:50 pm-1:40 am

1 stop9h 50m

Guayaquil Jose Joaquin de Olmedo

Sat 5/30

9:05 am-4:35 pm

1 stop6h 30m

$506

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 5/18

1:30 pm-1:40 am

1 stop13h 10m

Guayaquil Jose Joaquin de Olmedo

Sat 5/30

9:05 am-5:25 pm

1 stop7h 20m

$507

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 5/7

6:45 pm-1:40 am

1 stop7h 55m

Guayaquil Jose Joaquin de Olmedo

Sun 5/17

8:45 pm-2:05 pm

1 stop16h 20m

$509

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 5/21

6:45 pm-1:40 am

1 stop7h 55m

Guayaquil Jose Joaquin de Olmedo

Sun 6/7

8:45 pm-4:50 am

1 stop7h 05m

$510

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 5/7

6:45 pm-1:40 am

1 stop7h 55m

Guayaquil Jose Joaquin de Olmedo

Tue 5/19

4:40 pm-10:49 am

2 stops17h 09m

$512

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Tue 4/21

4:50 pm-1:40 am

1 stop9h 50m

Guayaquil Jose Joaquin de Olmedo

Fri 5/15

8:45 pm-11:50 am

2 stops14h 05m

$513

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 4/17

6:40 am-2:35 pm

1 stop8h 55m

Guayaquil Jose Joaquin de Olmedo

Fri 4/17

6:50 pm-2:15 pm

1 stop18h 25m

$514
Quickest round-trip

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 5/7

6:45 pm-1:40 am

1 stop7h 55m

Guayaquil Jose Joaquin de Olmedo

Tue 5/19

5:38 pm-11:29 pm

Nonstop4h 51m

$516

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 5/8

6:52 pm-2:45 pm

2 stops20h 53m

Guayaquil Jose Joaquin de Olmedo

Sun 5/17

8:45 pm-4:50 am

1 stop7h 05m

$520

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Guayaquil from

How to get the cheapest flight ticket from Santiago to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santiago and Guayaquil?

What is the cheapest month to fly to Guayaquil?

The month of October is another great option to travel to Guayaquil, with average flight prices from Santiago averaging around $419.

What is the cheapest day to depart on your flight to Guayaquil?

The cheapest day to depart from Santiago to Guayaquil is on a Saturday. Travelers who choose to depart for Guayaquil on a Saturday will often find tickets for as low as $206. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Guayaquil on Sunday is $565.

What is the cheapest Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flight route?

Fly from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo for the best Santiago Arturo Merino Benitez - Guayaquil Jose Joaquin de Olmedo flight prices

How far in advance should I book a flight to Guayaquil?

You are more likely to see cheaper flights to Guayaquil from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Guayaquil for around $459 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Guayaquil from Santiago for as low as $400 on momondo.

What cabin class options are available on Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flights?

There are 2 cabin classes available to choose from on Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santiago to Guayaquil flights?

You could potentially save up to 8% on your flight if you consider stops on a Santiago to Guayaquil flight.

How have Santiago to Guayaquil flight prices changed over time?

As of April 2026, prices for Santiago to Guayaquil flights are approximately 8% cheaper when compared to flights at the same time last year.

When to book flights from Santiago to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Guayaquil (SCL to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Guayaquil

Best Price Found

$224

Fastest flight time

7h 55m

Direct flights

Every day

Airports in Guayaquil

1 airport
The best one-way flight to Guayaquil from Santiago in the past 72 hours is $224. The best round-trip flight deal from Santiago to Guayaquil found on momondo in the last 72 hours is $527.
The fastest flight from Santiago to Guayaquil takes 7h 55m
Direct flights go from Santiago to Guayaquil every day.
There is 1 airport in Guayaquil. From Santiago there are direct flights to Guayaquil Jose Joaquin de Olmedo (GYE).
Search flight deals

Frequently asked questions about flying from Santiago to Guayaquil

  • How far is Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo by plane?

    The distance between Santiago Arturo Merino Benitez and Guayaquil Jose Joaquin de Olmedo is about 2238.9 mi. In terms of flight time, this usually takes a little over 7h 55m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport were last updated today.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The required travel and health documents for your Guayaquil Jose Joaquin de Olmedo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Guayaquil Jose Joaquin de Olmedo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Santiago to Guayaquil?

  • What is the most popular airline from Santiago to Guayaquil?

Best airlines flying from Santiago to Guayaquil

Compare and see reviews for airlines that fly from Santiago to Guayaquil with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $320Free CancellationRating
7.4
1,908 reviews
Search LATAM Airlines flights

  • LATAM Airlines Flights From Santiago to Guayaquil

    The lowest priced LATAM Airlines flight from Santiago to Guayaquil from the last 72 hours was $320. Generally, LATAM Airlines has 4 flights on this route every week with an average price of $494. LATAM Airlines is rated 7.4/10 by our users.

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Guayaquil?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to Guayaquil. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to Guayaquil with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Guayaquil from Santiago with this policy.

How can momondo help me find flights from Santiago to Guayaquil?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Santiago to Guayaquil.

I’m not ready to book a flight from Santiago to Guayaquil right now. Can momondo alert me if prices change?

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