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Cheap flights from Santiago to Guayaquil from $254

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to Guayaquil departing on 7/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santiago to Guayaquil

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
1:30 am - 2:35 pm
SCL
-
GYE
15h 05m
1 stop
Avianca Logo
9:10 am - 12:20 am
GYE
-
SCL
13h 10m
1 stop
$451Avianca
Fri, Sep 25 - Tue, Sep 29
Avianca Logo
1:30 am - 8:55 am
SCL
-
GYE
9h 25m
1 stop
Avianca Logo
9:05 am - 12:20 am
GYE
-
SCL
13h 15m
1 stop
$452Avianca
Wed, Sep 30 - Sun, Oct 4
Avianca Logo
1:30 am - 11:20 am
SCL
-
GYE
11h 50m
2 stops
Avianca Logo
9:05 am - 12:20 am
GYE
-
SCL
13h 15m
1 stop
$456Avianca
Wed, Sep 30 - Sun, Oct 4
Avianca Logo
7:40 am - 11:30 pm
SCL
-
GYE
17h 50m
1 stop
Avianca Logo
10:05 am - 12:20 am
GYE
-
SCL
12h 15m
1 stop
$457Avianca
Thu, Oct 1 - Sun, Oct 4
Avianca Logo
1:30 am - 11:20 am
SCL
-
GYE
11h 50m
2 stops
Avianca Logo
6:35 am - 12:20 am
GYE
-
SCL
15h 45m
2 stops
$458Avianca
Wed, Sep 30 - Sun, Oct 4
Avianca Logo
6:40 am - 2:35 pm
SCL
-
GYE
8h 55m
1 stop
Avianca Logo
10:05 am - 4:45 am
GYE
-
SCL
17h 40m
1 stop
$460Avianca
Fri, Jul 24 - Thu, Aug 20
Avianca Logo
6:40 am - 5:35 pm
SCL
-
GYE
11h 55m
1 stop
Avianca Logo
9:10 am - 11:20 pm
GYE
-
SCL
13h 10m
1 stop
$461Avianca
Mon, Aug 3 - Tue, Aug 18
Avianca Logo
6:40 am - 2:35 pm
SCL
-
GYE
8h 55m
1 stop
Avianca Logo
10:05 am - 4:45 am
GYE
-
SCL
17h 40m
1 stop
$464Avianca
Fri, Jul 24 - Thu, Aug 20
Avianca Logo
6:40 am - 2:35 pm
SCL
-
GYE
8h 55m
1 stop
Avianca Logo
10:05 am - 4:45 am
GYE
-
SCL
17h 40m
1 stop
$465Avianca
Fri, Jul 24 - Thu, Aug 20
Avianca Logo
6:40 am - 2:35 pm
SCL
-
GYE
8h 55m
1 stop
Avianca Logo
9:05 am - 11:20 pm
GYE
-
SCL
13h 15m
1 stop
$466Avianca
Mon, Aug 3 - Sun, Aug 23

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LATAM Airlines flights from Santiago to Guayaquil

Our best LATAM Airlines deals on Santiago to Guayaquil flight tickets
LATAM Airlines
Jul 24
SCL6:45 pmSantiago Arturo Merino Benitez
8h 00m
1 stop
GYE1:45 amGuayaquil Jose Joaquin de Olmedo
Aug 20
GYE5:38 pmGuayaquil Jose Joaquin de Olmedo
4h 51m
SCL11:29 pmSantiago Arturo Merino Benitez
$475
LATAM Airlines
Jul 23
SCL12:45 amSantiago Arturo Merino Benitez
5h 18m
GYE5:03 amGuayaquil Jose Joaquin de Olmedo
Aug 20
GYE5:38 pmGuayaquil Jose Joaquin de Olmedo
4h 51m
SCL11:29 pmSantiago Arturo Merino Benitez
$479
LATAM Airlines
Aug 2
SCL12:45 amSantiago Arturo Merino Benitez
5h 18m
GYE5:03 amGuayaquil Jose Joaquin de Olmedo
Aug 18
GYE5:38 pmGuayaquil Jose Joaquin de Olmedo
4h 51m
SCL11:29 pmSantiago Arturo Merino Benitez
$487

Avianca flights from Santiago to Guayaquil

Our best Avianca deals on Santiago to Guayaquil flight tickets
Avianca
Sep 25
SCL1:30 amSantiago Arturo Merino Benitez
15h 05m
1 stop
GYE2:35 pmGuayaquil Jose Joaquin de Olmedo
Sep 29
GYE9:10 amGuayaquil Jose Joaquin de Olmedo
13h 10m
1 stop
SCL12:20 amSantiago Arturo Merino Benitez
$451
Avianca
Sep 30
SCL1:30 amSantiago Arturo Merino Benitez
9h 25m
1 stop
GYE8:55 amGuayaquil Jose Joaquin de Olmedo
Oct 4
GYE9:05 amGuayaquil Jose Joaquin de Olmedo
13h 15m
1 stop
SCL12:20 amSantiago Arturo Merino Benitez
$452
Avianca
Sep 30
SCL1:30 amSantiago Arturo Merino Benitez
11h 50m
2 stops
GYE11:20 amGuayaquil Jose Joaquin de Olmedo
Oct 4
GYE9:05 amGuayaquil Jose Joaquin de Olmedo
13h 15m
1 stop
SCL12:20 amSantiago Arturo Merino Benitez
$456

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 2, 2026.
Use the filters below to find and compare flights from Santiago to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 9/25

1:30 am-2:35 pm

1 stop15h 05m

Guayaquil Jose Joaquin de Olmedo

Tue 9/29

9:10 am-12:20 am

1 stop13h 10m

$451

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 9/30

1:30 am-8:55 am

1 stop9h 25m

Guayaquil Jose Joaquin de Olmedo

Sun 10/4

9:05 am-12:20 am

1 stop13h 15m

$452

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 9/30

1:30 am-11:20 am

2 stops11h 50m

Guayaquil Jose Joaquin de Olmedo

Sun 10/4

9:05 am-12:20 am

1 stop13h 15m

$456

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Thu 10/1

7:40 am-11:30 pm

1 stop17h 50m

Guayaquil Jose Joaquin de Olmedo

Sun 10/4

10:05 am-12:20 am

1 stop12h 15m

$457

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Wed 9/30

1:30 am-11:20 am

2 stops11h 50m

Guayaquil Jose Joaquin de Olmedo

Sun 10/4

6:35 am-12:20 am

2 stops15h 45m

$458

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 7/24

6:40 am-2:35 pm

1 stop8h 55m

Guayaquil Jose Joaquin de Olmedo

Thu 8/20

10:05 am-4:45 am

1 stop17h 40m

$460

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 8/3

6:40 am-5:35 pm

1 stop11h 55m

Guayaquil Jose Joaquin de Olmedo

Tue 8/18

9:10 am-11:20 pm

1 stop13h 10m

$461

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 7/24

6:40 am-2:35 pm

1 stop8h 55m

Guayaquil Jose Joaquin de Olmedo

Thu 8/20

10:05 am-4:45 am

1 stop17h 40m

$464

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Fri 7/24

6:40 am-2:35 pm

1 stop8h 55m

Guayaquil Jose Joaquin de Olmedo

Thu 8/20

10:05 am-4:45 am

1 stop17h 40m

$465
Quickest round-trip

SantiagoGuayaquil

SCL - GYE

SCLGYE

Santiago Arturo Merino Benitez

Mon 8/3

6:40 am-2:35 pm

1 stop8h 55m

Guayaquil Jose Joaquin de Olmedo

Sun 8/23

9:05 am-11:20 pm

1 stop13h 15m

$466

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Guayaquil from

How to get the cheapest flight ticket from Santiago to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santiago and Guayaquil?

What is the cheapest month to fly to Guayaquil?

The month of August is another great option to travel to Guayaquil, with average flight prices from Santiago averaging around $426.

What is the cheapest day to depart on your flight to Guayaquil?

The cheapest day to depart from Santiago to Guayaquil is on a Saturday. Travelers who choose to depart for Guayaquil on a Saturday will often find tickets for as low as $419. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Guayaquil on Friday is $636.

What is the cheapest Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo flight route?

Fly from Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo for the best Santiago Arturo Merino Benitez - Guayaquil Jose Joaquin de Olmedo flight prices

How far in advance should I book a flight from Santiago to Guayaquil?

You are more likely to see cheaper flights to Guayaquil from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Guayaquil for around $471 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Guayaquil from Santiago for as low as $428 on momondo.

What cabin class options are available on Santiago to Guayaquil flights?

There are 2 cabin classes available to choose from on Santiago to Guayaquil flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Santiago to Guayaquil flights?

No. A direct flight is the cheapest option for a flight between Santiago to Guayaquil.

How have Santiago to Guayaquil flight prices changed over time?

As of July 2026, prices for Santiago to Guayaquil flights are approximately 23% more expensive when compared to flights at the same time last year.

When to book flights from Santiago to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to Guayaquil (SCL to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to Guayaquil

Best Price Found

$598

Fastest flight time

7h 55m

Direct flights

Every day

Airports in Guayaquil

1 airport
The best flight deal from Santiago to Guayaquil found on momondo in the last 72 hours is $598
The fastest flight from Santiago to Guayaquil takes 7h 55m
Direct flights go from Santiago to Guayaquil every day.
There is 1 airport in Guayaquil. From Santiago there are direct flights to Guayaquil Jose Joaquin de Olmedo (GYE).
Search flight deals

Frequently asked questions about flying from Santiago to Guayaquil

  • How far is Santiago Arturo Merino Benitez to Guayaquil Jose Joaquin de Olmedo by plane?

    The distance between Santiago Arturo Merino Benitez and Guayaquil Jose Joaquin de Olmedo is about 2238.9 mi. In terms of flight time, this usually takes a little over 7h 55m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport were last updated today.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The required travel and health documents for your Guayaquil Jose Joaquin de Olmedo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Guayaquil Jose Joaquin de Olmedo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Santiago to Guayaquil?

  • What is the most popular airline from Santiago to Guayaquil?

Best airlines flying from Santiago to Guayaquil

Compare and see reviews for airlines that fly from Santiago to Guayaquil with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $320Free CancellationRating
7.4
1,946 reviews
Search LATAM Airlines flights

  • LATAM Airlines Flights From Santiago to Guayaquil

    The lowest priced LATAM Airlines flight from Santiago to Guayaquil from the last 72 hours was $320. Generally, LATAM Airlines has 4 flights on this route every week with an average price of $527. LATAM Airlines is rated 7.4/10 by our users.

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to Guayaquil?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to Guayaquil. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to Guayaquil with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Guayaquil from Santiago with this policy.

How can momondo help me find flights from Santiago to Guayaquil?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Santiago to Guayaquil.

I’m not ready to book a flight from Santiago to Guayaquil right now. Can momondo alert me if prices change?

Price alerts on flights to Guayaquil from Santiago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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