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Cheap flights from Panama City to Medellín from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Medellín departing on 12/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Copa Airlines Logo
6:54 am - 8:18 amPTY-MDE
1h 24mnonstop
Copa Airlines Logo
10:46 am - 12:14 pmMDE-PTY
1h 28mnonstop
$202Copa Airlines
Find Deal
Wed, Nov 12 - Fri, Nov 14
Avianca Logo
2:55 am - 7:05 amPTY-MDE
4h 10m1 stop
Avianca Logo
9:00 pm - 1:00 amMDE-PTY
4h 00m1 stop
$208Avianca
Find Deal
Wed, Dec 17 - Tue, Dec 23
Avianca Logo
2:55 am - 7:05 amPTY-MDE
4h 10m1 stop
Avianca Logo
12:40 pm - 4:55 pmMDE-PTY
4h 15m1 stop
$209Avianca
Find Deal
Wed, Dec 17 - Tue, Dec 23
Avianca Logo
2:55 am - 7:05 amPTY-MDE
4h 10m1 stop
Avianca Logo
4:20 am - 8:50 amMDE-PTY
4h 30m1 stop
$213Avianca
Find Deal
Thu, Dec 11 - Sat, Dec 13
Avianca Logo
5:50 pm - 9:55 pmPTY-MDE
4h 05m1 stop
Avianca Logo
4:45 am - 8:50 amMDE-PTY
4h 05m1 stop
$215Avianca
Find Deal
Wed, Nov 5 - Sat, Nov 8
Avianca Logo
2:55 pm - 7:10 pmPTY-MDE
4h 15m1 stop
Avianca Logo
8:10 pm - 12:40 amMDE-PTY
4h 30m1 stop
$223Avianca
Find Deal
Tue, Dec 2 - Fri, Dec 12
Copa Airlines Logo
12:50 pm - 2:15 pmPTY-MDE
1h 25mnonstop
Copa Airlines Logo
10:46 am - 12:14 pmMDE-PTY
1h 28mnonstop
$224Copa Airlines
Find Deal
Fri, Dec 5 - Tue, Dec 9
Avianca Logo
2:55 am - 7:05 amPTY-MDE
4h 10m1 stop
Avianca Logo
8:10 pm - 12:40 amMDE-PTY
4h 30m1 stop
$234Avianca
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Wed, Nov 26 - Mon, Dec 1
Copa Airlines Logo
8:28 am - 9:51 amPTY-MDE
1h 23mnonstop
Copa Airlines Logo
6:20 pm - 7:49 pmMDE-PTY
1h 29mnonstop
$255Copa Airlines
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Wed, Dec 10 - Wed, Dec 24
Multiple Airlines Logo
6:54 am - 8:18 amPTY-MDE
1h 24mnonstop
Multiple Airlines Logo
8:10 pm - 12:40 amMDE-PTY
4h 30m1 stop
$273Multiple Airlines
Find Deal
Wed, Nov 5 - Mon, Nov 10

Avianca flights from Panama City to Medellín Jose Maria Cordova Intl Airport

Our best Avianca deals on Panama City to Medellín Jose Maria Cordova Intl Airport flight tickets
Avianca
Dec 17
PTY2:55 amPanama City Tocumen Intl
4h 10m
1 stop
MDE7:05 amMedellín Jose Maria Cordova Intl
Dec 23
MDE9:00 pmMedellín Jose Maria Cordova Intl
4h 00m
1 stop
PTY1:00 amPanama City Tocumen Intl
$208
Find similar
Avianca
Dec 17
PTY2:55 amPanama City Tocumen Intl
4h 10m
1 stop
MDE7:05 amMedellín Jose Maria Cordova Intl
Dec 23
MDE12:40 pmMedellín Jose Maria Cordova Intl
4h 15m
1 stop
PTY4:55 pmPanama City Tocumen Intl
$209
Find similar
Avianca
Dec 11
PTY2:55 amPanama City Tocumen Intl
4h 10m
1 stop
MDE7:05 amMedellín Jose Maria Cordova Intl
Dec 13
MDE4:20 amMedellín Jose Maria Cordova Intl
4h 30m
1 stop
PTY8:50 amPanama City Tocumen Intl
$213
Find similar

Copa Airlines flights from Panama City to Medellín Jose Maria Cordova Intl Airport

Our best Copa Airlines deals on Panama City to Medellín Jose Maria Cordova Intl Airport flight tickets
Copa Airlines
Nov 12
PTY6:54 amPanama City Tocumen Intl
1h 24m
MDE8:18 amMedellín Jose Maria Cordova Intl
Nov 14
MDE10:46 amMedellín Jose Maria Cordova Intl
1h 28m
PTY12:14 pmPanama City Tocumen Intl
$202
Find similar
Copa Airlines
Dec 5
PTY12:50 pmPanama City Tocumen Intl
1h 25m
MDE2:15 pmMedellín Jose Maria Cordova Intl
Dec 9
MDE10:46 amMedellín Jose Maria Cordova Intl
1h 28m
PTY12:14 pmPanama City Tocumen Intl
$224
Find similar
Copa Airlines
Dec 10
PTY8:28 amPanama City Tocumen Intl
1h 23m
MDE9:51 amMedellín Jose Maria Cordova Intl
Dec 24
MDE6:20 pmMedellín Jose Maria Cordova Intl
1h 29m
PTY7:49 pmPanama City Tocumen Intl
$255
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Medellín Jose Maria Cordova Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Panama City to Medellín Jose Maria Cordova Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 11/12

6:54 am-8:18 am

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Fri 11/14

10:46 am-12:14 pm

Nonstop1h 28m

$202

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 12/17

2:55 am-7:05 am

1 stop4h 10m

Medellín Jose Maria Cordova Intl

Tue 12/23

9:00 pm-1:00 am

1 stop4h 00m

$208

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 12/17

2:55 am-7:05 am

1 stop4h 10m

Medellín Jose Maria Cordova Intl

Tue 12/23

12:40 pm-4:55 pm

1 stop4h 15m

$209

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 12/11

2:55 am-7:05 am

1 stop4h 10m

Medellín Jose Maria Cordova Intl

Sat 12/13

4:20 am-8:50 am

1 stop4h 30m

$213

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 11/5

5:50 pm-9:55 pm

1 stop4h 05m

Medellín Jose Maria Cordova Intl

Sat 11/8

4:45 am-8:50 am

1 stop4h 05m

$215

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Tue 12/2

2:55 pm-7:10 pm

1 stop4h 15m

Medellín Jose Maria Cordova Intl

Fri 12/12

8:10 pm-12:40 am

1 stop4h 30m

$223

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 12/5

12:50 pm-2:15 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Tue 12/9

10:46 am-12:14 pm

Nonstop1h 28m

$224

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 11/26

2:55 am-7:05 am

1 stop4h 10m

Medellín Jose Maria Cordova Intl

Mon 12/1

8:10 pm-12:40 am

1 stop4h 30m

$234

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 12/10

8:28 am-9:51 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Wed 12/24

6:20 pm-7:49 pm

Nonstop1h 29m

$255

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 11/5

6:54 am-8:18 am

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Mon 11/10

8:10 pm-12:40 am

1 stop4h 30m

$273

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Panama City to Medellín Jose Maria Cordova Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Medellín Jose Maria Cordova Intl Airport?

In general, May is the cheapest month to fly from Panama City to Medellín Jose Maria Cordova Intl Airport. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $151. If you aren’t able to travel during the month of May, then book flights to Medellín Jose Maria Cordova Intl Airport from Panama City during July instead. Flights to Medellín Jose Maria Cordova Intl Airport in July, while not as cheap as those in May, still average around $161.

What is the cheapest day to depart on your flight to Medellín Jose Maria Cordova Intl Airport?

The cheapest day to depart from Panama City to Medellín Jose Maria Cordova Intl Airport is on a Wednesday. Travelers who choose to depart for Medellín Jose Maria Cordova Intl Airport on a Wednesday will often find tickets for as low as $251. On the other hand, Saturday is the most expensive day to depart from Panama City because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $272.

What is the cheapest time of day to depart on your flight to Medellín Jose Maria Cordova Intl Airport?

Our data shows that the cheapest Panama City to Medellín Jose Maria Cordova Intl Airport flights are usually those with departure times at noon. Our users have found flights to Medellín Jose Maria Cordova Intl Airport at noon for as low as $260. In contrast, the most expensive time of day to depart to Medellín Jose Maria Cordova Intl Airport is in the afternoon when prices are around $296.

What is the cheapest Panama City Tocumen Intl to Medellín Jose Maria Cordova Intl flight route?

Fly from Panama City Tocumen Intl to Medellín Jose Maria Cordova Intl for the best Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl flight prices

How far in advance should I book a flight to Medellín Jose Maria Cordova Intl Airport?

You are more likely to see cheaper flights to Medellín Jose Maria Cordova Intl Airport from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Medellín Jose Maria Cordova Intl Airport for around $178 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Medellín Jose Maria Cordova Intl Airport from Panama City for as low as $171 on momondo.

What cabin class options are available on Panama City Tocumen Intl to Medellín Jose Maria Cordova Intl flights?

There are 2 cabin classes available to choose from on Panama City Tocumen Intl to Medellín Jose Maria Cordova Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Panama City to Medellín Jose Maria Cordova Intl Airport flight prices changed over time?

As of October 2025, prices for Panama City to Medellín Jose Maria Cordova Intl Airport flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from Panama City to Medellín Jose Maria Cordova Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Medellín Jose Maria Cordova Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Medellín Jose Maria Cordova Intl Airport (PTY to MDE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Medellín Jose Maria Cordova Intl Airport

Best Price Found

$152

Fastest flight time

1h 21m

Direct flights

Every day
The best one-way flight to Medellín Jose Maria Cordova Intl Airport from Panama City in the past 72 hours is $152. The best round-trip flight deal from Panama City to Medellín Jose Maria Cordova Intl Airport found on momondo in the last 72 hours is $260.
The fastest flight from Panama City to Medellín Jose Maria Cordova Intl Airport takes 1h 21m
Direct flights go from Panama City to Medellín Jose Maria Cordova Intl Airport every day.
Search flight deals

  • How far is Panama City Tocumen Intl to Medellín Jose Maria Cordova Intl by plane?

    Medellín Jose Maria Cordova Intl is 341.6 mi away from Panama City Tocumen Intl. Flights usually cover this in 1h 21m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Medellín Jose Maria Cordova Intl Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Medellín Jose Maria Cordova Intl Airport were last updated today.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Medellín Jose Maria Cordova Intl Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Medellín Jose Maria Cordova Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Medellín Jose Maria Cordova Intl Airport.

  • What documentation or ID do you need to fly to Medellín Jose Maria Cordova Intl Airport?

    The necessary travel and health documents for your Medellín Jose Maria Cordova Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to Medellín Jose Maria Cordova Intl Airport?

  • What is the most popular airline from Panama City to Medellín Jose Maria Cordova Intl Airport?

Best airlines flying from Panama City to Medellín Jose Maria Cordova Intl Airport

Compare and see reviews for airlines that fly from Panama City to Medellín Jose Maria Cordova Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
WingoPriceFrom $126Free CancellationRating
0.0
0 reviews
Search Wingo flights
Copa AirlinesPriceFrom $126Free CancellationRating
7.6
1,563 reviews
Search Copa Airlines flights
AviancaPriceFrom $164Free CancellationRating
6.6
2,467 reviews
Search Avianca flights

  • Copa Airlines Flights From Panama City to Medellín Jose Maria Cordova Intl Airport

    Copa Airlines operates around 20 flights from Panama City to Medellín Jose Maria Cordova Intl Airport every week. The average price of these flights found in the last 72 hours has been $260, but momondo users have found Copa Airlines deals from Panama City to Medellín Jose Maria Cordova Intl Airport from as low as $126 round-trip. Copa Airlines has been scored 7.6/10 in 1,563 reviews.

Traveling to a place near Medellín?

Book flights to Medellín if you plan to visit one of these locations
Guatapé
Rionegro

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Why should I use momondo to find a flight deal from Panama City to Medellín?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Panama City to Medellín. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Panama City to Medellín with flexible booking policies on momondo?

Flights from Panama City to Medellín with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to Medellín?

Once all potential Panama City to Medellín flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Panama City to Medellín right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Panama City to Medellín flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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