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Cheap flights from Panama City to Medellín from $155

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Medellín departing on 10/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama City to Medellín

Cheap round-trip flights

Logo
3:20 am - 10:56 amPTY-MDE
7h 36m1 stop
Logo
7:22 am - 4:30 pmMDE-PTY
9h 08m1 stop
$280
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Wed, Sep 24 - Sun, Sep 28
Logo
2:55 pm - 8:43 pmPTY-MDE
5h 48m1 stop
Logo
6:58 am - 2:00 pmMDE-PTY
7h 02m1 stop
$287
Find Deal
Mon, Nov 3 - Mon, Nov 10
Logo
9:55 am - 3:26 pmPTY-MDE
5h 31m1 stop
Logo
5:08 am - 10:10 amMDE-PTY
5h 02m1 stop
$288
Find Deal
Thu, Sep 25 - Sun, Sep 28
Copa Airlines Logo
6:54 am - 8:17 amPTY-MDE
1h 23mnonstop
Copa Airlines Logo
6:37 am - 8:02 amMDE-PTY
1h 25mnonstop
$307Copa Airlines
Find Deal
Thu, Oct 16 - Sun, Oct 19
Avianca Logo
3:20 am - 8:07 amPTY-MDE
4h 47m1 stop
Avianca Logo
4:12 pm - 9:10 pmMDE-PTY
4h 58m1 stop
$314Avianca
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Thu, Oct 9 - Sun, Oct 12
Copa Airlines Logo
1:20 pm - 2:45 pmPTY-MDE
1h 25mnonstop
Copa Airlines Logo
3:15 pm - 4:44 pmMDE-PTY
1h 29mnonstop
$318Copa Airlines
Find Deal
Fri, Dec 5 - Tue, Dec 9
Avianca Logo
5:55 pm - 9:55 pmPTY-MDE
4h 00m1 stop
Avianca Logo
4:45 am - 8:50 amMDE-PTY
4h 05m1 stop
$319Avianca
Find Deal
Thu, Oct 30 - Sun, Nov 2
Avianca Logo
3:20 am - 8:07 amPTY-MDE
4h 47m1 stop
Avianca Logo
8:20 pm - 12:45 amMDE-PTY
4h 25m1 stop
$321Avianca
Find Deal
Tue, Oct 7 - Wed, Oct 15
Copa Airlines Logo
9:32 am - 10:56 amPTY-MDE
1h 24mnonstop
Copa Airlines Logo
6:24 am - 7:49 amMDE-PTY
1h 25mnonstop
$324Copa Airlines
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Fri, Nov 7 - Mon, Nov 10
Copa Airlines Logo
1:20 pm - 2:45 pmPTY-MDE
1h 25mnonstop
Copa Airlines Logo
6:20 pm - 7:47 pmMDE-PTY
1h 27mnonstop
$329Copa Airlines
Find Deal
Fri, Jan 2 - Fri, Jan 9

Avianca flights from Panama City to Medellín Jose Maria Cordova Intl Airport

Our best Avianca deals on Panama City to Medellín Jose Maria Cordova Intl Airport flight tickets
Avianca
Oct 9
PTY3:20 amPanama City Tocumen Intl
4h 47m
1 stop
MDE8:07 amMedellín Jose Maria Cordova Intl
Oct 12
MDE4:12 pmMedellín Jose Maria Cordova Intl
4h 58m
1 stop
PTY9:10 pmPanama City Tocumen Intl
$314
Find similar
Avianca
Oct 30
PTY5:55 pmPanama City Tocumen Intl
4h 00m
1 stop
MDE9:55 pmMedellín Jose Maria Cordova Intl
Nov 2
MDE4:45 amMedellín Jose Maria Cordova Intl
4h 05m
1 stop
PTY8:50 amPanama City Tocumen Intl
$319
Find similar
Avianca
Oct 7
PTY3:20 amPanama City Tocumen Intl
4h 47m
1 stop
MDE8:07 amMedellín Jose Maria Cordova Intl
Oct 15
MDE8:20 pmMedellín Jose Maria Cordova Intl
4h 25m
1 stop
PTY12:45 amPanama City Tocumen Intl
$321
Find similar

Copa Airlines flights from Panama City to Medellín Jose Maria Cordova Intl Airport

Our best Copa Airlines deals on Panama City to Medellín Jose Maria Cordova Intl Airport flight tickets
Copa Airlines
Sep 22
PTY7:01 amPanama City Tocumen Intl
1h 16m
MDE8:17 amMedellín Jose Maria Cordova Intl
Sep 25
MDE6:18 pmMedellín Jose Maria Cordova Intl
1h 29m
PTY7:47 pmPanama City Tocumen Intl
$307
Find similar
Copa Airlines
Dec 5
PTY1:20 pmPanama City Tocumen Intl
1h 25m
MDE2:45 pmMedellín Jose Maria Cordova Intl
Dec 9
MDE3:15 pmMedellín Jose Maria Cordova Intl
1h 29m
PTY4:44 pmPanama City Tocumen Intl
$318
Find similar
Copa Airlines
Sep 19
PTY3:36 pmPanama City Tocumen Intl
1h 24m
MDE5:00 pmMedellín Jose Maria Cordova Intl
Sep 23
MDE10:46 amMedellín Jose Maria Cordova Intl
1h 29m
PTY12:15 pmPanama City Tocumen Intl
$324
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Medellín Jose Maria Cordova Intl Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 14, 2025.
Use the filters below to find and compare flights from Panama City to Medellín Jose Maria Cordova Intl Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 9/24

3:20 am-10:56 am

1 stop7h 36m

Medellín Jose Maria Cordova Intl

Sun 9/28

7:22 am-4:30 pm

1 stop9h 08m

$280

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 11/3

2:55 pm-8:43 pm

1 stop5h 48m

Medellín Jose Maria Cordova Intl

Mon 11/10

6:58 am-2:00 pm

1 stop7h 02m

$287

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 9/25

9:55 am-3:26 pm

1 stop5h 31m

Medellín Jose Maria Cordova Intl

Sun 9/28

5:08 am-10:10 am

1 stop5h 02m

$288

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 10/16

6:54 am-8:17 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Sun 10/19

6:37 am-8:02 am

Nonstop1h 25m

$307

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 10/9

3:20 am-8:07 am

1 stop4h 47m

Medellín Jose Maria Cordova Intl

Sun 10/12

4:12 pm-9:10 pm

1 stop4h 58m

$314

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 12/5

1:20 pm-2:45 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Tue 12/9

3:15 pm-4:44 pm

Nonstop1h 29m

$318

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 10/30

5:55 pm-9:55 pm

1 stop4h 00m

Medellín Jose Maria Cordova Intl

Sun 11/2

4:45 am-8:50 am

1 stop4h 05m

$319

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Tue 10/7

3:20 am-8:07 am

1 stop4h 47m

Medellín Jose Maria Cordova Intl

Wed 10/15

8:20 pm-12:45 am

1 stop4h 25m

$321

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 11/7

9:32 am-10:56 am

Nonstop1h 24m

Medellín Jose Maria Cordova Intl

Mon 11/10

6:24 am-7:49 am

Nonstop1h 25m

$324

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 1/2

1:20 pm-2:45 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Fri 1/9

6:20 pm-7:47 pm

Nonstop1h 27m

$329

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Panama City to Medellín Jose Maria Cordova Intl Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and Medellín Jose Maria Cordova Intl Airport?

What is the cheapest month to fly to Medellín Jose Maria Cordova Intl Airport?

In general, May is the cheapest month to fly from Panama City to Medellín Jose Maria Cordova Intl Airport. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $151. If you aren’t able to travel during the month of May, then book flights to Medellín Jose Maria Cordova Intl Airport from Panama City during July instead. Flights to Medellín Jose Maria Cordova Intl Airport in July, while not as cheap as those in May, still average around $161.

What is the cheapest day to depart on your flight to Medellín Jose Maria Cordova Intl Airport?

The cheapest day to depart from Panama City to Medellín Jose Maria Cordova Intl Airport is on a Wednesday. Travelers who choose to depart for Medellín Jose Maria Cordova Intl Airport on a Wednesday will often find tickets for as low as $251. On the other hand, Sunday is the most expensive day to depart from Panama City because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $265.

What is the cheapest time of day to depart on your flight to Medellín Jose Maria Cordova Intl Airport?

Our data shows that the cheapest Panama City to Medellín Jose Maria Cordova Intl Airport flights are usually those with departure times in the evening. Our users have found flights to Medellín Jose Maria Cordova Intl Airport in the evening for as low as $210. In contrast, the most expensive time of day to depart to Medellín Jose Maria Cordova Intl Airport is in the afternoon when prices are around $282.

What is the cheapest Panama City Tocumen Intl to Medellín Jose Maria Cordova Intl flight route?

Fly from Panama City Tocumen Intl to Medellín Jose Maria Cordova Intl for the best Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl flight prices

How far in advance should I book a flight to Medellín Jose Maria Cordova Intl Airport?

You are more likely to see cheaper flights to Medellín Jose Maria Cordova Intl Airport from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Medellín Jose Maria Cordova Intl Airport for around $181 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Medellín Jose Maria Cordova Intl Airport from Panama City for as low as $173 on momondo.

What cabin class options are available on Panama City Tocumen Intl to Medellín Jose Maria Cordova Intl flights?

There are 2 cabin classes available to choose from on Panama City Tocumen Intl to Medellín Jose Maria Cordova Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Panama City to Medellín Jose Maria Cordova Intl Airport flight prices changed over time?

As of September 2025, prices for Panama City to Medellín Jose Maria Cordova Intl Airport flights are approximately 6% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to Medellín Jose Maria Cordova Intl Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Medellín Jose Maria Cordova Intl Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Medellín Jose Maria Cordova Intl Airport (PTY to MDE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Medellín Jose Maria Cordova Intl Airport

Best Price Found

$162

Fastest flight time

1h 16m

Direct flights

Every day
The best one-way flight to Medellín Jose Maria Cordova Intl Airport from Panama City in the past 72 hours is $162. The best round-trip flight deal from Panama City to Medellín Jose Maria Cordova Intl Airport found on momondo in the last 72 hours is $260.
The fastest flight from Panama City to Medellín Jose Maria Cordova Intl Airport takes 1h 16m
Direct flights go from Panama City to Medellín Jose Maria Cordova Intl Airport every day.
Search flight deals

  • How far is Panama City Tocumen Intl to Medellín Jose Maria Cordova Intl by plane?

    Medellín Jose Maria Cordova Intl is 341.6 mi away from Panama City Tocumen Intl. Flights usually cover this in 1h 21m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Medellín Jose Maria Cordova Intl Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Medellín Jose Maria Cordova Intl Airport were last updated today.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Medellín Jose Maria Cordova Intl Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Medellín Jose Maria Cordova Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Medellín Jose Maria Cordova Intl Airport.

  • What documentation or ID do you need to fly to Medellín Jose Maria Cordova Intl Airport?

    The necessary travel and health documents for your Medellín Jose Maria Cordova Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Panama City to Medellín Jose Maria Cordova Intl Airport?

  • What is the most popular airline from Panama City to Medellín Jose Maria Cordova Intl Airport?

Best airlines flying from Panama City to Medellín Jose Maria Cordova Intl Airport

Compare and see reviews for airlines that fly from Panama City to Medellín Jose Maria Cordova Intl Airport with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $123Free CancellationRating
7.6
1,531 reviews
Search Copa Airlines flights
WingoPriceFrom $126Free CancellationRating
7.3
136 reviews
Search Wingo flights
AviancaPriceFrom $168Free CancellationRating
6.7
2,435 reviews
Search Avianca flights

  • Copa Airlines Flights From Panama City to Medellín Jose Maria Cordova Intl Airport

    Copa Airlines operates around 55 flights from Panama City to Medellín Jose Maria Cordova Intl Airport every week. The average price of these flights found in the last 72 hours has been $260, but momondo users have found Copa Airlines deals from Panama City to Medellín Jose Maria Cordova Intl Airport from as low as $123 round-trip. Copa Airlines has been scored 7.6/10 in 1,531 reviews.

Traveling to a place near Medellín?

Book flights to Medellín if you plan to visit one of these locations
Guatapé
Rionegro

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Medellín?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Panama City to Medellín. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Panama City to Medellín with flexible booking policies on momondo?

Flights from Panama City to Medellín with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to Medellín?

Once all potential Panama City to Medellín flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Panama City to Medellín right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Panama City to Medellín flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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