Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Panama City to Brussels from $502

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Brussels departing on 10/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Panama City to Brussels

Cheap round-trip flights

Iberia Logo
6:20 pm - 7:00 pmPTY-BRU
18h 40m1 stop
Iberia Logo
7:00 am - 4:45 pmBRU-PTY
15h 45m1 stop
$713Iberia
Find Deal
Mon, Nov 10 - Wed, Feb 4
Air Europa Logo
9:30 pm - 5:45 pmPTY-BRU
14h 15m1 stop
Air Europa Logo
6:55 pm - 7:45 pmBRU-PTY
30h 50m1 stop
$724Air Europa
Find Deal
Mon, Nov 10 - Wed, Feb 4
Turkish Airlines Logo
9:45 pm - 10:35 amPTY-BRU
30h 50m1 stop
Turkish Airlines Logo
3:15 pm - 5:05 pmBRU-PTY
31h 50m2 stops
$837Turkish Airlines
Find Deal
Mon, Nov 10 - Wed, Feb 4
KLM Logo
10:05 pm - 10:20 pmPTY-BRU
18h 15m1 stop
KLM Logo
2:45 pm - 4:30 pmBRU-PTY
31h 45m1 stop
$840KLM
Find Deal
Sat, Feb 14 - Thu, Feb 26
KLM Logo
10:05 pm - 10:20 pmPTY-BRU
18h 15m1 stop
KLM Logo
2:45 pm - 4:30 pmBRU-PTY
31h 45m1 stop
$841KLM
Find Deal
Sat, Feb 14 - Thu, Feb 26
Turkish Airlines Logo
9:45 pm - 5:20 pmPTY-BRU
37h 35m1 stop
Turkish Airlines Logo
3:15 pm - 5:05 pmBRU-PTY
31h 50m2 stops
$851Turkish Airlines
Find Deal
Sat, Feb 14 - Thu, Feb 26
Multiple Airlines Logo
9:45 am - 2:35 pmPTY-BRU
22h 50m2 stops
Multiple Airlines Logo
9:55 pm - 12:40 amBRU-PTY
32h 45m2 stops
$990Multiple Airlines
Find Deal
Sat, Feb 14 - Thu, Feb 26
Multiple Airlines Logo
5:25 pm - 10:30 pmPTY-BRU
22h 05m2 stops
Multiple Airlines Logo
7:05 am - 3:40 pmBRU-PTY
15h 35m1 stop
$1,005Multiple Airlines
Find Deal
Thu, Oct 16 - Thu, Oct 23
United Airlines Logo
9:45 am - 8:00 pmPTY-BRU
27h 15m2 stops
United Airlines Logo
12:00 pm - 1:50 pmBRU-PTY
32h 50m2 stops
$1,078United Airlines
Find Deal
Thu, Oct 16 - Thu, Oct 23
United Airlines Logo
10:00 am - 8:05 amPTY-BRU
16h 05m1 stop
United Airlines Logo
10:10 am - 1:31 pmBRU-PTY
33h 21m2 stops
$1,176United Airlines
Find Deal
Wed, Dec 10 - Wed, Dec 24

Air Europa flights from Panama City to Brussels Bruxelles-National Airport

Our best Air Europa deals on Panama City to Brussels Bruxelles-National Airport flight tickets
Air Europa
Nov 10
PTY9:30 pmPanama City Tocumen Intl
14h 15m
1 stop
BRU5:45 pmBrussels Bruxelles-National
Feb 4
BRU6:55 pmBrussels Bruxelles-National
30h 50m
1 stop
PTY7:45 pmPanama City Tocumen Intl
$724
Find similar
Air Europa
Feb 14
PTY9:30 pmPanama City Tocumen Intl
14h 15m
1 stop
BRU5:45 pmBrussels Bruxelles-National
Feb 26
BRU10:45 amBrussels Bruxelles-National
15h 00m
1 stop
PTY7:45 pmPanama City Tocumen Intl
$786
Find similar
Air Europa
Feb 14
PTY9:30 pmPanama City Tocumen Intl
30h 20m
1 stop
BRU9:50 amBrussels Bruxelles-National
Feb 26
BRU10:45 amBrussels Bruxelles-National
15h 00m
1 stop
PTY7:45 pmPanama City Tocumen Intl
$790
Find similar

United Airlines flights from Panama City to Brussels Bruxelles-National Airport

Our best United Airlines deals on Panama City to Brussels Bruxelles-National Airport flight tickets
United Airlines
Oct 16
PTY9:45 amPanama City Tocumen Intl
27h 15m
2 stops
BRU8:00 pmBrussels Bruxelles-National
Oct 23
BRU12:00 pmBrussels Bruxelles-National
32h 50m
2 stops
PTY1:50 pmPanama City Tocumen Intl
$1,078
Find similar
United Airlines
Dec 10
PTY10:00 amPanama City Tocumen Intl
16h 05m
1 stop
BRU8:05 amBrussels Bruxelles-National
Dec 24
BRU10:10 amBrussels Bruxelles-National
33h 21m
2 stops
PTY1:31 pmPanama City Tocumen Intl
$1,176
Find similar
United Airlines
Dec 11
PTY9:11 amPanama City Tocumen Intl
22h 04m
2 stops
BRU1:15 pmBrussels Bruxelles-National
Dec 24
BRU10:10 amBrussels Bruxelles-National
33h 12m
1 stop
PTY1:22 pmPanama City Tocumen Intl
$1,196
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Panama City to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 11/10

6:20 pm-7:00 pm

1 stop18h 40m

Brussels Bruxelles-National

Wed 2/4

7:00 am-4:45 pm

1 stop15h 45m

$713

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 11/10

9:30 pm-5:45 pm

1 stop14h 15m

Brussels Bruxelles-National

Wed 2/4

6:55 pm-7:45 pm

1 stop30h 50m

$724

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 11/10

9:45 pm-10:35 am

1 stop30h 50m

Brussels Bruxelles-National

Wed 2/4

3:15 pm-5:05 pm

2 stops31h 50m

$837

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Sat 2/14

10:05 pm-10:20 pm

1 stop18h 15m

Brussels Bruxelles-National

Thu 2/26

2:45 pm-4:30 pm

1 stop31h 45m

$840

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Sat 2/14

10:05 pm-10:20 pm

1 stop18h 15m

Brussels Bruxelles-National

Thu 2/26

2:45 pm-4:30 pm

1 stop31h 45m

$841

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Sat 2/14

9:45 pm-5:20 pm

1 stop37h 35m

Brussels Bruxelles-National

Thu 2/26

3:15 pm-5:05 pm

2 stops31h 50m

$851

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Sat 2/14

9:45 am-2:35 pm

2 stops22h 50m

Brussels Bruxelles-National

Thu 2/26

9:55 pm-12:40 am

2 stops32h 45m

$990

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Thu 10/16

5:25 pm-10:30 pm

2 stops22h 05m

Brussels Bruxelles-National

Thu 10/23

7:05 am-3:40 pm

1 stop15h 35m

$1,005

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Thu 10/16

9:45 am-8:00 pm

2 stops27h 15m

Brussels Bruxelles-National

Thu 10/23

12:00 pm-1:50 pm

2 stops32h 50m

$1,078

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Wed 12/10

10:00 am-8:05 am

1 stop16h 05m

Brussels Bruxelles-National

Wed 12/24

10:10 am-1:31 pm

2 stops33h 21m

$1,176

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Brussels from

How to get the cheapest flight ticket from Panama City to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and Brussels Bruxelles-National Airport?

What is the cheapest month to fly to Brussels Bruxelles-National Airport?

The cheapest month to fly to Brussels Bruxelles-National Airport from Panama City is in January. Flight prices, which tend to average around $761, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to Brussels Bruxelles-National Airport from Panama City during February instead. Flights to Brussels Bruxelles-National Airport in February, while not as cheap as those in January, still average around $783.

What is the cheapest day to depart on your flight to Brussels Bruxelles-National Airport?

The cheapest day to depart from Panama City to Brussels Bruxelles-National Airport is on a Monday. Travelers who choose to depart for Brussels Bruxelles-National Airport on a Monday will often find tickets for as low as $789. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Panama City to Brussels Bruxelles-National Airport for around $1,006.

What is the cheapest time of day to depart on your flight to Brussels Bruxelles-National Airport?

Our most recent data shows that the best time of day to fly to Brussels Bruxelles-National Airport is in the evening. Flights from Panama City to Brussels Bruxelles-National Airport during this time can be as low as $827. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $992 on average. Flights to Brussels Bruxelles-National Airport from Panama City in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to Brussels Bruxelles-National Airport?

You are more likely to see cheaper flights to Brussels Bruxelles-National Airport from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Brussels Bruxelles-National Airport for around $865 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Brussels Bruxelles-National Airport from Panama City for as low as $769 on momondo.

How have Panama City to Brussels Bruxelles-National Airport flight prices changed over time?

As of September 2025, prices for Panama City to Brussels Bruxelles-National Airport flights are approximately 37% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Brussels Bruxelles-National Airport (PTY to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Brussels Bruxelles-National Airport

Direct flights

None
There are no direct flights from Panama City to Brussels Bruxelles-National Airport. There are no popular flight routes from Panama City to Brussels Bruxelles-National Airport.
Search flight deals

  • How far is Panama City Tocumen Intl to Brussels Bruxelles-National by plane?

    The distance between Panama City Tocumen Intl and Brussels Bruxelles-National is about 5473.2 mi. 13h 30m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport refresh daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The required travel and health documents for your Brussels Bruxelles-National Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Brussels Bruxelles-National Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Panama City to Brussels Bruxelles-National Airport?

Best airlines flying from Panama City to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Panama City to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
Air FrancePriceFrom $785Free CancellationRating
7.4
1,468 reviews
Search Air France flights
Air EuropaPriceFrom $797Free CancellationRating
7.0
557 reviews
Search Air Europa flights

Traveling to a place near Brussels?

Book flights to Brussels if you plan to visit one of these locations
Bruges
Ghent
Leuven
Charleroi
Hasselt
Spa
Namur
Aalst
Dinant
Mons
Zaventem
Waterloo
Genk
Mechelen
Francorchamps
Knokke-Heist
Tournai
Durbuy
Oostkamp
Halle

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Brussels?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Brussels. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Brussels with flexible booking policies on momondo?

Yes. All flights to Brussels from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Brussels?

Once you have performed a search for Panama City to Brussels flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Brussels right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to Brussels flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Brussels Bruxelles-National Airport trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Fri 10/17
Fri 10/24
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Brussels

Popular cities in Belgium

Popular flights according to clicks in the last 7 days on momondo
Flights to Charleroi Brussels Airportfrom $427