Which layover airport has the shortest travel time from Panama City to Brussels Bruxelles-National Airport?

Flights connecting via Amsterdam (AMS) have the shortest average one-way travel time: 12h 50m.

What is the most punctual flight time for Panama City to Brussels flights?

Generally, flights departing in the evening tend to experience fewer delays. Flights in the evening have, in the past, seen delays more frequently in comparison.

Which airport is the most popular layover for flights between Panama City and Brussels Bruxelles-National Airport?

Amsterdam (AMS) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest connection time from Panama City to Brussels Bruxelles-National Airport?

Amsterdam (AMS) has the shortest average layover time for this route: 1h 40m.

Which layover airport offers the lowest fares from Panama City to Brussels Bruxelles-National Airport?

Flights via Madrid (MAD) offer the lowest average round-trip price of $734.

How often are flights from Panama City to Brussels delayed?

Historically, on average around 0% of flights between Panama City and Brussels have experienced a delay on any given week. The average delay length over the past 12 months has been 0 minutes.

What is the cheapest airline that flies from Panama City Tocumen Intl to Brussels Bruxelles-National?

Air Europa and Turkish Airlines are the most popular carriers operating from Panama City Tocumen Intl to Brussels Bruxelles-National

What day of the week experiences the fewest flight delays on this route?

Friday is statistically the day of the week which experiences the fewest number of delays on this flight route. Friday has historically seen more delays on average compared to the rest of the week.

When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport?

Prices for flights from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport refresh daily.

How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport?

As of February 2026, there are 2 operators available to choose from for flights from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport.

How old do you have to be to fly from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport.

What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

The required travel and health documents for your Brussels Bruxelles-National Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Brussels Bruxelles-National Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$601 Cheap Flights from Panama City to Brussels Bruxelles-National Airport in 2026

Q: What is the typical price of a round-trip flight between Panama City and Brussels Bruxelles-National Airport?

Prices are currently low for flights on this route. Typical prices usually range from $768 to $887. The lowest price recently found on this route was $729.

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One-way

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Enter your travel dates to find the best prices.

9:45 pm - 5:20 pm

PTY

BRU

37h 35m

1 stop

11:35 am - 7:50 pm

BRU

PTY

38h 15m

1 stop

$729Turkish Airlines

Mon, Mar 16 - Tue, Mar 24

9:45 pm - 5:20 pm

PTY

BRU

37h 35m

1 stop

6:20 pm - 7:50 pm

BRU

PTY

31h 30m

1 stop

$730Turkish Airlines

Mon, Mar 16 - Tue, Mar 24

10:20 pm - 10:10 am

PTY

BRU

28h 50m

1 stop

7:20 am - 6:25 pm

BRU

PTY

42h 05m

2 stops

$739Turkish Airlines

Mon, Apr 13 - Sat, Apr 25

9:45 pm - 10:35 am

PTY

BRU

30h 50m

1 stop

6:20 pm - 5:05 pm

BRU

PTY

28h 45m

2 stops

$740Turkish Airlines

Mon, Mar 16 - Tue, Mar 24

9:45 pm - 5:20 pm

PTY

BRU

37h 35m

1 stop

3:15 pm - 5:05 pm

BRU

PTY

31h 50m

2 stops

$741Turkish Airlines

Mon, Mar 16 - Tue, Mar 24

9:45 pm - 5:20 pm

PTY

BRU

37h 35m

1 stop

6:30 pm - 7:50 pm

BRU

PTY

31h 20m

1 stop

$753Turkish Airlines

Mon, Mar 16 - Fri, Mar 20

9:45 pm - 5:20 pm

PTY

BRU

37h 35m

1 stop

6:30 pm - 7:50 pm

BRU

PTY

31h 20m

1 stop

$754Turkish Airlines

Mon, Mar 16 - Fri, Mar 20

8:25 pm - 5:40 pm

PTY

BRU

14h 15m

1 stop

10:45 am - 6:40 pm

BRU

PTY

14h 55m

1 stop

$761Air Europa

Mon, May 25 - Fri, May 29

8:25 pm - 5:40 pm

PTY

BRU

14h 15m

1 stop

10:45 am - 6:40 pm

BRU

PTY

14h 55m

1 stop

$762Air Europa

Mon, May 25 - Fri, May 29

8:25 pm - 5:40 pm

PTY

BRU

14h 15m

1 stop

10:45 am - 6:40 pm

BRU

PTY

14h 55m

1 stop

$773Air Europa

Thu, Jun 4 - Sat, Jun 13

Iberia flights from Panama City to Brussels Bruxelles-National Airport

Our best Iberia deals on Panama City to Brussels Bruxelles-National Airport flight tickets

Iberia

Jun 4

PTY1:27 pmPanama City Tocumen Intl

26h 03m

2 stops

BRU10:30 pmBrussels Bruxelles-National

Jun 13

BRU7:45 pmBrussels Bruxelles-National

31h 15m

1 stop

PTY8:00 pmPanama City Tocumen Intl

$980

Iberia

Feb 14

PTY4:05 pmPanama City Tocumen Intl

37h 25m

2 stops

BRU11:30 amBrussels Bruxelles-National

Feb 26

BRU12:10 pmBrussels Bruxelles-National

33h 05m

2 stops

PTY3:15 pmPanama City Tocumen Intl

$1,235

Iberia

Feb 14

PTY4:05 pmPanama City Tocumen Intl

37h 25m

2 stops

BRU11:30 amBrussels Bruxelles-National

Feb 26

BRU7:00 amBrussels Bruxelles-National

38h 15m

2 stops

PTY3:15 pmPanama City Tocumen Intl

$1,324

Turkish Airlines flights from Panama City to Brussels Bruxelles-National Airport

Our best Turkish Airlines deals on Panama City to Brussels Bruxelles-National Airport flight tickets

Turkish Airlines

Mar 16

PTY9:45 pmPanama City Tocumen Intl

37h 35m

1 stop

BRU5:20 pmBrussels Bruxelles-National

Mar 24

BRU3:15 pmBrussels Bruxelles-National

34h 35m

1 stop

PTY7:50 pmPanama City Tocumen Intl

$729

Turkish Airlines

Mar 16

PTY9:45 pmPanama City Tocumen Intl

37h 35m

1 stop

BRU5:20 pmBrussels Bruxelles-National

Mar 24

BRU6:20 pmBrussels Bruxelles-National

31h 30m

1 stop

PTY7:50 pmPanama City Tocumen Intl

$730

Turkish Airlines

Mar 16

PTY9:45 pmPanama City Tocumen Intl

37h 35m

1 stop

BRU5:20 pmBrussels Bruxelles-National

Mar 24

BRU6:20 pmBrussels Bruxelles-National

28h 45m

2 stops

PTY5:05 pmPanama City Tocumen Intl

$740

momondo Fare Finder

Use the filters below to find and compare flights from Panama City to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 3/16

9:45 pm-5:20 pm

1 stop37h 35m

Brussels Bruxelles-National

Tue 3/24

11:35 am-7:50 pm

1 stop38h 15m

$729

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 3/16

9:45 pm-5:20 pm

1 stop37h 35m

Brussels Bruxelles-National

Tue 3/24

6:20 pm-7:50 pm

1 stop31h 30m

$730

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 4/13

10:20 pm-10:10 am

1 stop28h 50m

Brussels Bruxelles-National

Sat 4/25

7:20 am-6:25 pm

2 stops42h 05m

$739

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 3/16

9:45 pm-10:35 am

1 stop30h 50m

Brussels Bruxelles-National

Tue 3/24

6:20 pm-5:05 pm

2 stops28h 45m

$740

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 3/16

9:45 pm-5:20 pm

1 stop37h 35m

Brussels Bruxelles-National

Tue 3/24

3:15 pm-5:05 pm

2 stops31h 50m

$741

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 3/16

9:45 pm-5:20 pm

1 stop37h 35m

Brussels Bruxelles-National

Fri 3/20

6:30 pm-7:50 pm

1 stop31h 20m

$753

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 3/16

9:45 pm-5:20 pm

1 stop37h 35m

Brussels Bruxelles-National

Fri 3/20

6:30 pm-7:50 pm

1 stop31h 20m

$754

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 5/25

8:25 pm-5:40 pm

1 stop14h 15m

Brussels Bruxelles-National

Fri 5/29

10:45 am-6:40 pm

1 stop14h 55m

$761

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Mon 5/25

8:25 pm-5:40 pm

1 stop14h 15m

Brussels Bruxelles-National

Fri 5/29

10:45 am-6:40 pm

1 stop14h 55m

$762

Panama CityBrussels

PTY - BRU

PTYBRU

Panama City Tocumen Intl

Thu 6/4

8:25 pm-5:40 pm

1 stop14h 15m

Brussels Bruxelles-National

Sat 6/13

10:45 am-6:40 pm

1 stop14h 55m

$773

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Panama City to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Delays

Layovers

What is the typical price of a round-trip flight between Panama City and Brussels Bruxelles-National Airport?

What is the cheapest month to fly to Brussels Bruxelles-National Airport?

The cheapest month to fly to Brussels Bruxelles-National Airport from Panama City is in February. Flight prices, which tend to average around $809, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of February, then book flights to Brussels Bruxelles-National Airport from Panama City during September instead. Flights to Brussels Bruxelles-National Airport in September, while not as cheap as those in February, still average around $811.

How far in advance should I book a flight to Brussels Bruxelles-National Airport?

You are more likely to see cheaper flights to Brussels Bruxelles-National Airport from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Brussels Bruxelles-National Airport for around $910 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Brussels Bruxelles-National Airport from Panama City for as low as $775 on momondo.

How have Panama City to Brussels Bruxelles-National Airport flight prices changed over time?

As of February 2026, prices for Panama City to Brussels Bruxelles-National Airport flights are approximately 11% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Panama City to Brussels Bruxelles-National Airport (PTY to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Brussels Bruxelles-National Airport

Fastest flight time	18h 25m
Direct flights	None

The fastest flight from Panama City to Brussels Bruxelles-National Airport takes 18h 25m

There are no direct flights from Panama City to Brussels Bruxelles-National Airport. There are no popular flight routes from Panama City to Brussels Bruxelles-National Airport.

Search flight deals

How far is Panama City Tocumen Intl to Brussels Bruxelles-National by plane?
The distance between Panama City Tocumen Intl and Brussels Bruxelles-National is about 5473.2 mi. 18h 25m is a normal flight duration for this route.
When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport?
Prices for flights from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport refresh daily.
How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport?
As of February 2026, there are 2 operators available to choose from for flights from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport.
How old do you have to be to fly from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Brussels Bruxelles-National Airport.
What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?
The required travel and health documents for your Brussels Bruxelles-National Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Brussels Bruxelles-National Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from Panama City to Brussels Bruxelles-National Airport?
Based on momondo bookings for flights between Panama City and Brussels Bruxelles-National Airport, the leading airline is Air Europa, making up 69% of the total bookings. Other popular airlines include Air France with 31%.

Best airlines flying from Panama City to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Panama City to Brussels Bruxelles-National Airport with momondo

Airline	Rating	Free Cancellation	Price
Air France	PriceFrom $785	Free Cancellation	Rating 7.4 1,532 reviews		Search Air France flights
Air Europa	PriceFrom $797	Free Cancellation	Rating 6.9 588 reviews		Search Air Europa flights

Ghent

Bruges

Leuven

Charleroi

Zaventem

Hasselt

Namur

Dinant

Genk

Spa

Mons

Waterloo

Durbuy

Aalst

Knokke-Heist

Mechelen

Francorchamps

Tournai

Oostkamp

Halle

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Brussels?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Brussels. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Brussels with flexible booking policies on momondo?

Yes. All flights to Brussels from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Brussels?

Once you have performed a search for Panama City to Brussels flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Brussels right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama City to Brussels flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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Flights to Charleroi Brussels Airportfrom $437

Cheap flights from Panama City to Brussels from $601

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Brussels departing on 7/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Iberia flights from Panama City to Brussels Bruxelles-National Airport

Our best Iberia deals on Panama City to Brussels Bruxelles-National Airport flight tickets

Turkish Airlines flights from Panama City to Brussels Bruxelles-National Airport

Our best Turkish Airlines deals on Panama City to Brussels Bruxelles-National Airport flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Panama City to Brussels Bruxelles-National Airport that are best for you.

See travel insights to Brussels from

How to get the cheapest flight ticket from Panama City to Brussels Bruxelles-National Airport

What is the typical price of a round-trip flight between Panama City and Brussels Bruxelles-National Airport?

What is the cheapest month to fly to Brussels Bruxelles-National Airport?

How far in advance should I book a flight to Brussels Bruxelles-National Airport?

How have Panama City to Brussels Bruxelles-National Airport flight prices changed over time?

What is the cheapest airline that flies from Panama City Tocumen Intl to Brussels Bruxelles-National?

How often are flights from Panama City to Brussels delayed?

What is the most punctual flight time for Panama City to Brussels flights?

What day of the week experiences the fewest flight delays on this route?

Which airport is the most popular layover for flights between Panama City and Brussels Bruxelles-National Airport?

Which layover airport offers the lowest fares from Panama City to Brussels Bruxelles-National Airport?

Which layover airport has the shortest travel time from Panama City to Brussels Bruxelles-National Airport?

Which layover airport has the shortest connection time from Panama City to Brussels Bruxelles-National Airport?

When to book flights from Panama City to Brussels Bruxelles-National Airport

Cheap Panama City to Brussels Bruxelles-National Airport (PTY to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Brussels Bruxelles-National Airport

Fastest flight time

Direct flights

Best airlines flying from Panama City to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Panama City to Brussels Bruxelles-National Airport with momondo

Traveling to a place near Brussels?

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Brussels?

Can I find flights from Panama City to Brussels with flexible booking policies on momondo?

How can momondo help me find flights from Panama City to Brussels?

I’m not ready to book a flight from Panama City to Brussels right now. Can momondo alert me if prices change?

An easier way to manage your Brussels Bruxelles-National Airport trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

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List of cabin classes available on flights landing in Brussels. Availability may vary depending on flight origin and airline.

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