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Cheap flights from Panama City, Florida to Guayaquil from $428

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Guayaquil departing on 5/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Panama City, Florida to Guayaquil

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:21 am - 9:12 pm
ECP
-
GYE
13h 51m
2 stops
American Airlines Logo
2:31 pm - 10:03 am
GYE
-
ECP
19h 32m
2 stops
$668American Airlines
Thu, May 7 - Thu, May 14
American Airlines Logo
7:21 am - 9:12 pm
ECP
-
GYE
13h 51m
2 stops
American Airlines Logo
2:31 pm - 11:53 am
GYE
-
ECP
21h 22m
2 stops
$688American Airlines
Thu, May 7 - Sun, May 31
American Airlines Logo
10:48 am - 1:31 pm
ECP
-
GYE
26h 43m
2 stops
American Airlines Logo
2:31 pm - 12:01 pm
GYE
-
ECP
21h 30m
2 stops
$722American Airlines
Wed, Apr 15 - Thu, May 14

American Airlines flights from Panama City, Florida to Guayaquil

Our best American Airlines deals on Panama City, Florida to Guayaquil flight tickets
American Airlines
May 7
ECP7:21 amPanama City NW Florida Beaches
13h 51m
2 stops
GYE9:12 pmGuayaquil Jose Joaquin de Olmedo
May 14
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
19h 32m
2 stops
ECP10:03 amPanama City NW Florida Beaches
$668
American Airlines
May 7
ECP7:21 amPanama City NW Florida Beaches
13h 51m
2 stops
GYE9:12 pmGuayaquil Jose Joaquin de Olmedo
May 31
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
21h 22m
2 stops
ECP11:53 amPanama City NW Florida Beaches
$688
American Airlines
Apr 15
ECP10:48 amPanama City NW Florida Beaches
26h 43m
2 stops
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
May 14
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
21h 30m
2 stops
ECP12:01 pmPanama City NW Florida Beaches
$722

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Guayaquil that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Thu 5/7

7:21 am-9:12 pm

2 stops13h 51m

Guayaquil Jose Joaquin de Olmedo

Thu 5/14

2:31 pm-10:03 am

2 stops19h 32m

$668

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Thu 5/7

7:21 am-9:12 pm

2 stops13h 51m

Guayaquil Jose Joaquin de Olmedo

Sun 5/31

2:31 pm-11:53 am

2 stops21h 22m

$688

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Wed 4/15

10:48 am-1:31 pm

2 stops26h 43m

Guayaquil Jose Joaquin de Olmedo

Thu 5/14

2:31 pm-12:01 pm

2 stops21h 30m

$722
Cheapest one-way
Quickest one-way

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Sat 5/2

7:21 am-9:12 pm

2 stops13h 51m

$428

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Sat 5/2

12:52 pm-1:31 pm

2 stops24h 39m

$431

Panama CityGuayaquil

ECP - GYE

ECPGYE

Panama City NW Florida Beaches

Sat 5/2

4:40 pm-1:31 pm

2 stops20h 51m

$432

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Guayaquil from

How to get the cheapest flight ticket from Panama City, Florida to Guayaquil

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City NW Florida Beaches to Guayaquil Jose Joaquin de Olmedo?

American Airlines is the most popular carrier operating from Panama City NW Florida Beaches to Guayaquil Jose Joaquin de Olmedo

When to book flights from Panama City, Florida to Guayaquil

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Guayaquil according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Guayaquil (ECP to GYE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Guayaquil

Fastest flight time

30h 00m

Direct flights

None
The fastest flight from Panama City, Florida to Guayaquil takes 30h 00m
There are no direct flights from Panama City, Florida to Guayaquil. There are no popular flight routes from Panama City, Florida to Guayaquil.
Search flight deals

  • How far is Panama City NW Florida Beaches to Guayaquil Jose Joaquin de Olmedo by plane?

    The distance between Panama City NW Florida Beaches and Guayaquil Jose Joaquin de Olmedo is about 2266.0 mi. Flights usually cover this in 30h 00m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Guayaquil Jose Joaquin de Olmedo Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Guayaquil Jose Joaquin de Olmedo Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Panama City NW Florida Beaches Airport to Guayaquil Jose Joaquin de Olmedo Airport.

  • What documentation or ID do you need to fly to Guayaquil Jose Joaquin de Olmedo Airport?

    The necessary travel and health documents for your Guayaquil Jose Joaquin de Olmedo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Guayaquil?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to Guayaquil for you.

Can I find flights from Panama City to Guayaquil with flexible booking policies on momondo?

Yes. All flights to Guayaquil from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Guayaquil?

Once you have performed a search for Panama City to Guayaquil flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Guayaquil right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Guayaquil from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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