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Cheap flights from North Carolina to Santa Cruz de la Sierra from $336

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from North Carolina to Santa Cruz de la Sierra departing on 10/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from North Carolina to Santa Cruz de la Sierra

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
4:19 pm - 3:38 amRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
11h 19m1 stop Panama City Tocumen Intl
Copa Airlines Logo
1:12 am - 2:28 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
13h 16m1 stop Panama City Tocumen Intl
$572Copa Airlines
Sun, Oct 4 - Sat, Oct 17
Multiple Airlines Logo
6:05 am - 3:38 amRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
21h 33m2 stops Chicago O'Hare Intl Panama City Tocumen Intl
Multiple Airlines Logo
3:35 am - 11:59 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
20h 24m2 stops Bogotá El Dorado Washington, D.C. Dulles Intl
$601Multiple Airlines
Sun, Oct 4 - Sat, Oct 17
United Airlines Logo
9:00 am - 10:44 pmRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
37h 44m2 stops Newark Panama City Tocumen Intl
United Airlines Logo
11:47 am - 1:49 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
50h 02m3 stops Panama City Tocumen Intl Houston George Bush Intcntl Chicago O'Hare Intl
$603United Airlines
Mon, Oct 19 - Thu, Oct 22
United Airlines Logo
7:05 am - 10:44 pmRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
39h 39m2 stops Newark Panama City Tocumen Intl
United Airlines Logo
11:49 am - 1:44 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
26h 55m3 stops Panama City Tocumen Intl Houston George Bush Intcntl Chicago O'Hare Intl
$603United Airlines
Tue, Oct 20 - Thu, Nov 5
United Airlines Logo
6:05 am - 10:44 pmRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
40h 39m2 stops Chicago O'Hare Intl Panama City Tocumen Intl
United Airlines Logo
11:47 am - 1:49 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
50h 02m3 stops Panama City Tocumen Intl Houston George Bush Intcntl Chicago O'Hare Intl
$603United Airlines
Mon, Oct 19 - Thu, Oct 22
United Airlines Logo
6:15 am - 10:38 pmRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
39h 23m2 stops Chicago O'Hare Intl Panama City Tocumen Intl
United Airlines Logo
11:49 am - 1:44 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
26h 55m3 stops Panama City Tocumen Intl Houston George Bush Intcntl Chicago O'Hare Intl
$603United Airlines
Thu, Nov 5 - Sat, Nov 21
United Airlines Logo
6:00 am - 3:38 amRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
21h 38m2 stops Washington, D.C. Dulles Intl Panama City Tocumen Intl
United Airlines Logo
11:47 am - 1:49 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
50h 02m3 stops Panama City Tocumen Intl Houston George Bush Intcntl Chicago O'Hare Intl
$603United Airlines
Mon, Oct 19 - Thu, Oct 22
United Airlines Logo
9:00 am - 10:44 pmRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
37h 44m2 stops Newark Panama City Tocumen Intl
United Airlines Logo
11:49 am - 1:44 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
26h 55m3 stops Panama City Tocumen Intl Houston George Bush Intcntl Chicago O'Hare Intl
$603United Airlines
Tue, Oct 20 - Thu, Nov 5
United Airlines Logo
10:40 am - 10:44 pmRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
36h 04m2 stops Washington, D.C. Dulles Intl Panama City Tocumen Intl
United Airlines Logo
11:49 am - 1:44 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
26h 55m3 stops Panama City Tocumen Intl Houston George Bush Intcntl Chicago O'Hare Intl
$603United Airlines
Tue, Oct 20 - Thu, Nov 5
Copa Airlines Logo
4:21 pm - 3:38 amRDU  Raleigh-Durham-VVI Santa Cruz de la Sierra Viru Viru Intl
11h 17m1 stop Panama City Tocumen Intl
Copa Airlines Logo
1:12 am - 2:28 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-RDU Raleigh-Durham
13h 16m1 stop Panama City Tocumen Intl
$616Copa Airlines
Wed, Sep 2 - Tue, Sep 22

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Copa Airlines flights from North Carolina to Santa Cruz de la Sierra

Our best Copa Airlines deals on North Carolina to Santa Cruz de la Sierra flight tickets
Copa Airlines
Oct 4
RDU4:19 pmRaleigh-Durham
11h 19m
1 stop
VVI3:38 amSanta Cruz de la Sierra Viru Viru Intl
Oct 17
VVI1:12 amSanta Cruz de la Sierra Viru Viru Intl
13h 16m
1 stop
RDU2:28 pmRaleigh-Durham
$572
Copa Airlines
Sep 2
RDU4:21 pmRaleigh-Durham
11h 17m
1 stop
VVI3:38 amSanta Cruz de la Sierra Viru Viru Intl
Sep 22
VVI1:12 amSanta Cruz de la Sierra Viru Viru Intl
13h 16m
1 stop
RDU2:28 pmRaleigh-Durham
$616
Copa Airlines
Sep 2
RDU4:21 pmRaleigh-Durham
11h 17m
1 stop
VVI3:38 amSanta Cruz de la Sierra Viru Viru Intl
Sep 22
VVI1:12 amSanta Cruz de la Sierra Viru Viru Intl
13h 16m
1 stop
RDU2:28 pmRaleigh-Durham
$659

LATAM Airlines flights from North Carolina to Santa Cruz de la Sierra

Our best LATAM Airlines deals on North Carolina to Santa Cruz de la Sierra flight tickets
LATAM Airlines
Sep 2
RDU1:53 pmRaleigh-Durham
38h 42m
2 stops
VVI4:35 amSanta Cruz de la Sierra Viru Viru Intl
Sep 23
VVI8:41 amSanta Cruz de la Sierra Viru Viru Intl
59h 05m
3 stops
RDU7:46 pmRaleigh-Durham
$1,509
LATAM Airlines
Nov 3
RDU2:00 pmRaleigh-Durham
43h 31m
3 stops
VVI10:31 amSanta Cruz de la Sierra Viru Viru Intl
Nov 20
VVI5:30 amSanta Cruz de la Sierra Viru Viru Intl
18h 46m
2 stops
RDU11:16 pmRaleigh-Durham
$1,525
LATAM Airlines
Sep 2
RDU1:53 pmRaleigh-Durham
38h 42m
2 stops
VVI4:35 amSanta Cruz de la Sierra Viru Viru Intl
Sep 23
VVI8:41 amSanta Cruz de la Sierra Viru Viru Intl
59h 05m
3 stops
RDU7:46 pmRaleigh-Durham
$1,560

momondo Fare Finder

 
Customize your flight search to find flights from North Carolina to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from North Carolina to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Sun 10/4

4:19 pm-3:38 am

1 stop11h 19m

Santa Cruz de la Sierra Viru Viru Intl

Sat 10/17

1:12 am-2:28 pm

1 stop13h 16m

$572

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Sun 10/4

6:05 am-3:38 am

2 stops21h 33m

Santa Cruz de la Sierra Viru Viru Intl

Sat 10/17

3:35 am-11:59 pm

2 stops20h 24m

$601

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Mon 10/19

9:00 am-10:44 pm

2 stops37h 44m

Santa Cruz de la Sierra Viru Viru Intl

Thu 10/22

11:47 am-1:49 pm

3 stops50h 02m

$603

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Tue 10/20

7:05 am-10:44 pm

2 stops39h 39m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/5

11:49 am-1:44 pm

3 stops26h 55m

$603

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Mon 10/19

6:05 am-10:44 pm

2 stops40h 39m

Santa Cruz de la Sierra Viru Viru Intl

Thu 10/22

11:47 am-1:49 pm

3 stops50h 02m

$603

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Thu 11/5

6:15 am-10:38 pm

2 stops39h 23m

Santa Cruz de la Sierra Viru Viru Intl

Sat 11/21

11:49 am-1:44 pm

3 stops26h 55m

$603

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Mon 10/19

6:00 am-3:38 am

2 stops21h 38m

Santa Cruz de la Sierra Viru Viru Intl

Thu 10/22

11:47 am-1:49 pm

3 stops50h 02m

$603

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Tue 10/20

9:00 am-10:44 pm

2 stops37h 44m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/5

11:49 am-1:44 pm

3 stops26h 55m

$603

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Tue 10/20

10:40 am-10:44 pm

2 stops36h 04m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/5

11:49 am-1:44 pm

3 stops26h 55m

$603
Quickest round-trip

RaleighSanta Cruz de la Sierra

RDU Raleigh-Durham - VVI Santa Cruz de la Sierra Viru Viru Intl

RDUVVI

Raleigh-Durham

Wed 9/2

4:21 pm-3:38 am

1 stop11h 17m

Santa Cruz de la Sierra Viru Viru Intl

Tue 9/22

1:12 am-2:28 pm

1 stop13h 16m

$616

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santa Cruz de la Sierra from

How to get the cheapest flight ticket from North Carolina to Santa Cruz de la Sierra

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on North Carolina to Santa Cruz de la Sierra flights?

You could potentially save up to 26% on your flight if you consider stops on a North Carolina to Santa Cruz de la Sierra flight.

Cheap North Carolina to Santa Cruz de la Sierra flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from North Carolina to Santa Cruz de la Sierra

Fastest flight time

16h 44m

Direct flights

None
The fastest flight from North Carolina to Santa Cruz de la Sierra takes 16h 44m
There are no direct flights from North Carolina to Santa Cruz de la Sierra. There are no popular flight routes from North Carolina to Santa Cruz de la Sierra.
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Frequently asked questions about flying from North Carolina to Santa Cruz de la Sierra

  • When did momondo last update prices for flights from North Carolina to Santa Cruz de la Sierra Viru Viru Intl Airport?

    Prices for flights from North Carolina to Santa Cruz de la Sierra Viru Viru Intl Airport were last updated today.

  • How many operators does momondo search for flights from North Carolina to Santa Cruz de la Sierra Viru Viru Intl Airport?

  • How old do you have to be to fly from North Carolina to Santa Cruz de la Sierra Viru Viru Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from North Carolina to Santa Cruz de la Sierra Viru Viru Intl Airport.

  • What documentation or ID do you need to fly to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The travel and health documents you'll need for your trip to Santa Cruz de la Sierra Viru Viru Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Santa Cruz de la Sierra Viru Viru Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from North Carolina to Santa Cruz de la Sierra

Compare and see reviews for airlines that fly from North Carolina to Santa Cruz de la Sierra with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $411Free CancellationRating
7.6
1,559 reviews
Search Copa Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from North Carolina to Santa Cruz de la Sierra?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from North Carolina to Santa Cruz de la Sierra for you.

Can I find flights from North Carolina to Santa Cruz de la Sierra with flexible booking policies on momondo?

All flight searches from North Carolina to Santa Cruz de la Sierra on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from North Carolina to Santa Cruz de la Sierra?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santa Cruz de la Sierra from North Carolina.

I’m not ready to book a flight from North Carolina to Santa Cruz de la Sierra right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santa Cruz de la Sierra from North Carolina. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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