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Cheap flights from Missouri to Santo Domingo from $178

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Santo Domingo departing on 4/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Missouri to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
3:33 pm - 9:49 am
STL
-
SDQ
41h 16m
2 stops
Frontier Logo
12:21 pm - 8:52 am
SDQ
-
STL
21h 31m
2 stops
$560Frontier
Fri, Jul 17 - Tue, Jul 21
Delta Logo
6:00 am - 1:24 pm
STL
-
SDQ
6h 24m
1 stop
Delta Logo
2:49 pm - 11:59 pm
SDQ
-
STL
10h 10m
1 stop
$590Delta
Wed, May 13 - Tue, May 19
Copa Airlines Logo
9:58 am - 10:54 am
MCI
-
SDQ
23h 56m
2 stops
Copa Airlines Logo
12:40 pm - 8:41 am
SDQ
-
MCI
21h 01m
2 stops
$591Copa Airlines
Wed, Apr 29 - Mon, May 4
Copa Airlines Logo
5:45 pm - 11:41 am
MCI
-
SDQ
16h 56m
2 stops
Copa Airlines Logo
6:04 am - 8:41 am
SDQ
-
MCI
27h 37m
2 stops
$593Copa Airlines
Tue, Apr 28 - Tue, May 5
United Airlines Logo
8:00 am - 10:46 pm
MCI
-
SDQ
13h 46m
2 stops
United Airlines Logo
1:10 pm - 10:18 pm
SDQ
-
MCI
10h 08m
1 stop
$595United Airlines
Tue, Apr 28 - Tue, May 5
Delta Logo
6:45 am - 6:01 pm
STL
-
SDQ
10h 16m
2 stops
Delta Logo
6:05 am - 5:16 pm
SDQ
-
STL
12h 11m
2 stops
$595Delta
Wed, May 13 - Tue, May 19
Delta Logo
6:00 am - 1:24 pm
STL
-
SDQ
6h 24m
1 stop
Delta Logo
2:48 pm - 9:29 pm
SDQ
-
STL
7h 41m
1 stop
$610Delta
Fri, May 15 - Fri, May 22
American Airlines Logo
5:24 am - 2:56 pm
STL
-
SDQ
8h 32m
1 stop
American Airlines Logo
6:00 am - 10:24 pm
SDQ
-
STL
17h 24m
1 stop
$615American Airlines
Tue, May 12 - Sun, May 17
American Airlines Logo
6:29 am - 10:55 pm
STL
-
SDQ
15h 26m
2 stops
American Airlines Logo
1:45 pm - 11:59 pm
SDQ
-
STL
11h 14m
1 stop
$620American Airlines
Sun, May 17 - Sun, May 24
American Airlines Logo
5:25 am - 6:35 pm
STL
-
SDQ
12h 10m
2 stops
American Airlines Logo
7:00 am - 4:33 pm
SDQ
-
STL
10h 33m
2 stops
$635American Airlines
Thu, Jun 4 - Tue, Jun 9

Copa Airlines flights from Missouri to Santo Domingo

Our best Copa Airlines deals on Missouri to Santo Domingo flight tickets
Copa Airlines
Apr 29
MCI9:58 amKansas City
23h 56m
2 stops
SDQ10:54 amSanto Domingo Las Americas
May 4
SDQ12:40 pmSanto Domingo Las Americas
21h 01m
2 stops
MCI8:41 amKansas City
$591
Copa Airlines
Apr 28
MCI5:45 pmKansas City
16h 56m
2 stops
SDQ11:41 amSanto Domingo Las Americas
May 5
SDQ6:04 amSanto Domingo Las Americas
27h 37m
2 stops
MCI8:41 amKansas City
$593

United Airlines flights from Missouri to Santo Domingo

Our best United Airlines deals on Missouri to Santo Domingo flight tickets
United Airlines
Apr 28
MCI8:00 amKansas City
13h 46m
2 stops
SDQ10:46 pmSanto Domingo Las Americas
May 5
SDQ1:10 pmSanto Domingo Las Americas
10h 08m
1 stop
MCI10:18 pmKansas City
$595
United Airlines
Apr 6
STL11:37 amLambert-St Louis
10h 09m
1 stop
SDQ10:46 pmSanto Domingo Las Americas
Apr 8
SDQ1:10 pmSanto Domingo Las Americas
11h 01m
2 stops
STL11:11 pmLambert-St Louis
$727
United Airlines
May 16
STL7:11 pmLambert-St Louis
17h 59m
2 stops
SDQ2:10 pmSanto Domingo Las Americas
May 23
SDQ3:20 pmSanto Domingo Las Americas
9h 15m
1 stop
STL11:35 pmLambert-St Louis
$755

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 4, 2026.
Use the filters below to find and compare flights from Missouri to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 7/17

3:33 pm-9:49 am

2 stops41h 16m

Santo Domingo Las Americas

Tue 7/21

12:21 pm-8:52 am

2 stops21h 31m

$560

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 5/13

6:00 am-1:24 pm

1 stop6h 24m

Santo Domingo Las Americas

Tue 5/19

2:49 pm-11:59 pm

1 stop10h 10m

$590

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Wed 4/29

9:58 am-10:54 am

2 stops23h 56m

Santo Domingo Las Americas

Mon 5/4

12:40 pm-8:41 am

2 stops21h 01m

$591

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Tue 4/28

5:45 pm-11:41 am

2 stops16h 56m

Santo Domingo Las Americas

Tue 5/5

6:04 am-8:41 am

2 stops27h 37m

$593

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Tue 4/28

8:00 am-10:46 pm

2 stops13h 46m

Santo Domingo Las Americas

Tue 5/5

1:10 pm-10:18 pm

1 stop10h 08m

$595

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 5/13

6:45 am-6:01 pm

2 stops10h 16m

Santo Domingo Las Americas

Tue 5/19

6:05 am-5:16 pm

2 stops12h 11m

$595
Quickest round-trip

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 5/15

6:00 am-1:24 pm

1 stop6h 24m

Santo Domingo Las Americas

Fri 5/22

2:48 pm-9:29 pm

1 stop7h 41m

$610

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 5/12

5:24 am-2:56 pm

1 stop8h 32m

Santo Domingo Las Americas

Sun 5/17

6:00 am-10:24 pm

1 stop17h 24m

$615

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 5/17

6:29 am-10:55 pm

2 stops15h 26m

Santo Domingo Las Americas

Sun 5/24

1:45 pm-11:59 pm

1 stop11h 14m

$620

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 6/4

5:25 am-6:35 pm

2 stops12h 10m

Santo Domingo Las Americas

Tue 6/9

7:00 am-4:33 pm

2 stops10h 33m

$635

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Missouri to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until February to fly from Missouri, when ticket prices are also cheap, with an average price of $580.

Can stopping save me money on Missouri to Santo Domingo flights?

You could potentially save up to 31% on your flight if you consider stops on a Missouri to Santo Domingo flight.

Cheap Missouri to Santo Domingo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Santo Domingo

Fastest flight time

6h 12m

Direct flights

None
The fastest flight from Missouri to Santo Domingo takes 6h 12m
There are no direct flights from Missouri to Santo Domingo. There are no popular flight routes from Missouri to Santo Domingo.
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Frequently asked questions about flying from Missouri to Santo Domingo

  • When did momondo last update prices for flights from Missouri to Santo Domingo Las Americas Airport?

    Prices for flights from Missouri to Santo Domingo Las Americas Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Missouri to Santo Domingo Las Americas Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Santo Domingo

Compare and see reviews for airlines that fly from Missouri to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $517Free CancellationRating
7.9
8,383 reviews
Search Delta flights
American AirlinesPriceFrom $521Free CancellationRating
7.1
11,556 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Santo Domingo?

It is quick and easy to find Missouri to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Missouri to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Missouri which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Missouri to Santo Domingo?

Once all potential Missouri to Santo Domingo flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Missouri to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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