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Cheap flights from Missouri to Santo Domingo from $185

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Santo Domingo departing on 5/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Missouri to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
3:49 pm - 11:56 am
STL
-
SDQ
18h 07m
1 stop
Frontier Logo
10:46 am - 11:19 pm
SDQ
-
STL
13h 33m
1 stop
$394Frontier
Mon, Mar 2 - Mon, Mar 9
Spirit Airlines Logo
12:24 pm - 1:38 am
MCI
-
SDQ
12h 14m
1 stop
Spirit Airlines Logo
2:52 am - 11:29 am
SDQ
-
MCI
9h 37m
1 stop
$412Spirit Airlines
Tue, Mar 24 - Mon, Mar 30
Frontier Logo
4:51 pm - 9:41 am
STL
-
SDQ
15h 50m
1 stop
Frontier Logo
10:46 am - 11:19 pm
SDQ
-
STL
13h 33m
1 stop
$419Frontier
Fri, Mar 27 - Mon, Mar 30
Frontier Logo
1:09 pm - 10:51 am
STL
-
SDQ
19h 42m
2 stops
Frontier Logo
10:56 am - 11:37 pm
SDQ
-
STL
13h 41m
1 stop
$434Frontier
Fri, Mar 6 - Sat, Mar 14
Spirit Airlines Logo
12:24 pm - 1:38 am
MCI
-
SDQ
12h 14m
1 stop
Spirit Airlines Logo
2:52 am - 11:29 am
SDQ
-
MCI
9h 37m
1 stop
$437Spirit Airlines
Tue, Mar 31 - Mon, Apr 6
Spirit Airlines Logo
12:24 pm - 1:38 am
MCI
-
SDQ
12h 14m
1 stop
Spirit Airlines Logo
2:20 pm - 11:53 pm
SDQ
-
MCI
10h 33m
2 stops
$451Spirit Airlines
Tue, Mar 31 - Tue, Apr 7
Spirit Airlines Logo
11:26 am - 2:20 pm
MCI
-
SDQ
24h 54m
1 stop
Spirit Airlines Logo
2:20 pm - 11:29 am
SDQ
-
MCI
22h 09m
1 stop
$453Spirit Airlines
Sun, Mar 1 - Tue, Mar 24
Multiple Airlines Logo
12:24 pm - 1:38 am
MCI
-
SDQ
12h 14m
1 stop
Multiple Airlines Logo
3:35 pm - 5:09 pm
SDQ
-
MCI
26h 34m
3 stops
$458Multiple Airlines
Tue, Mar 31 - Tue, Apr 7
Spirit Airlines Logo
12:24 pm - 1:38 am
MCI
-
SDQ
12h 14m
1 stop
Spirit Airlines Logo
2:20 pm - 11:53 pm
SDQ
-
MCI
10h 33m
2 stops
$460Spirit Airlines
Fri, Mar 27 - Mon, Mar 30
Frontier Logo
4:51 pm - 9:41 am
STL
-
SDQ
15h 50m
1 stop
Frontier Logo
11:40 am - 10:30 am
SDQ
-
STL
23h 50m
2 stops
$461Frontier
Fri, Mar 27 - Sat, Apr 4

Frontier flights from Missouri to Santo Domingo

Our best Frontier deals on Missouri to Santo Domingo flight tickets
Frontier
Mar 2
STL3:49 pmLambert-St Louis
18h 07m
1 stop
SDQ11:56 amSanto Domingo Las Americas
Mar 9
SDQ10:46 amSanto Domingo Las Americas
13h 33m
1 stop
STL11:19 pmLambert-St Louis
$394
Frontier
Mar 27
STL4:51 pmLambert-St Louis
15h 50m
1 stop
SDQ9:41 amSanto Domingo Las Americas
Mar 30
SDQ10:46 amSanto Domingo Las Americas
13h 33m
1 stop
STL11:19 pmLambert-St Louis
$419
Frontier
Mar 6
STL1:09 pmLambert-St Louis
19h 42m
2 stops
SDQ10:51 amSanto Domingo Las Americas
Mar 14
SDQ10:56 amSanto Domingo Las Americas
13h 41m
1 stop
STL11:37 pmLambert-St Louis
$434

American Airlines flights from Missouri to Santo Domingo

Our best American Airlines deals on Missouri to Santo Domingo flight tickets
American Airlines
Apr 15
MCI5:00 amKansas City
8h 59m
1 stop
SDQ2:59 pmSanto Domingo Las Americas
Apr 20
SDQ6:00 amSanto Domingo Las Americas
17h 20m
1 stop
MCI10:20 pmKansas City
$559
American Airlines
Apr 15
MCI5:30 amKansas City
10h 25m
2 stops
SDQ4:55 pmSanto Domingo Las Americas
Apr 20
SDQ6:00 amSanto Domingo Las Americas
17h 20m
1 stop
MCI10:20 pmKansas City
$563
American Airlines
May 10
MCI11:05 amKansas City
10h 47m
2 stops
SDQ10:52 pmSanto Domingo Las Americas
May 17
SDQ5:55 pmSanto Domingo Las Americas
17h 20m
2 stops
MCI10:15 amKansas City
$568

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 16, 2026.
Use the filters below to find and compare flights from Missouri to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 3/2

3:49 pm-11:56 am

1 stop18h 07m

Santo Domingo Las Americas

Mon 3/9

10:46 am-11:19 pm

1 stop13h 33m

$394

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Tue 3/24

12:24 pm-1:38 am

1 stop12h 14m

Santo Domingo Las Americas

Mon 3/30

2:52 am-11:29 am

1 stop9h 37m

$412

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

4:51 pm-9:41 am

1 stop15h 50m

Santo Domingo Las Americas

Mon 3/30

10:46 am-11:19 pm

1 stop13h 33m

$419

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/6

1:09 pm-10:51 am

2 stops19h 42m

Santo Domingo Las Americas

Sat 3/14

10:56 am-11:37 pm

1 stop13h 41m

$434

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Tue 3/31

12:24 pm-1:38 am

1 stop12h 14m

Santo Domingo Las Americas

Mon 4/6

2:52 am-11:29 am

1 stop9h 37m

$437

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Tue 3/31

12:24 pm-1:38 am

1 stop12h 14m

Santo Domingo Las Americas

Tue 4/7

2:20 pm-11:53 pm

2 stops10h 33m

$451

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Sun 3/1

11:26 am-2:20 pm

1 stop24h 54m

Santo Domingo Las Americas

Tue 3/24

2:20 pm-11:29 am

1 stop22h 09m

$453

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Tue 3/31

12:24 pm-1:38 am

1 stop12h 14m

Santo Domingo Las Americas

Tue 4/7

3:35 pm-5:09 pm

3 stops26h 34m

$458

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Fri 3/27

12:24 pm-1:38 am

1 stop12h 14m

Santo Domingo Las Americas

Mon 3/30

2:20 pm-11:53 pm

2 stops10h 33m

$460

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 3/27

4:51 pm-9:41 am

1 stop15h 50m

Santo Domingo Las Americas

Sat 4/4

11:40 am-10:30 am

2 stops23h 50m

$461

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Missouri to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in September, then you should wait until February to fly from Missouri, when ticket prices are also cheap, with an average price of $584.

Cheap Missouri to Santo Domingo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Santo Domingo

Fastest flight time

6h 21m

Direct flights

None
The fastest flight from Missouri to Santo Domingo takes 6h 21m
There are no direct flights from Missouri to Santo Domingo. There are no popular flight routes from Missouri to Santo Domingo.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Santo Domingo Las Americas Airport?

    Prices for flights from Missouri to Santo Domingo Las Americas Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Missouri to Santo Domingo Las Americas Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Santo Domingo

Compare and see reviews for airlines that fly from Missouri to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $262Free CancellationRating
7.9
8,204 reviews
Search Delta flights
American AirlinesPriceFrom $492Free CancellationRating
7.2
11,294 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Santo Domingo?

It is quick and easy to find Missouri to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Missouri to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Missouri which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Missouri to Santo Domingo?

Once all potential Missouri to Santo Domingo flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Missouri to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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