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Cheap flights from Missouri to Santo Domingo from $315

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Santo Domingo departing on 8/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Missouri to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
3:33 pm - 11:06 am
STL
-
SDQ
42h 33m
2 stops
Frontier Logo
12:21 pm - 5:30 pm
SDQ
-
STL
30h 09m
2 stops
$532Frontier
Tue, Aug 18 - Wed, Aug 26
Delta Logo
6:00 am - 1:16 pm
STL
-
SDQ
6h 16m
1 stop
Delta Logo
6:05 am - 10:15 pm
SDQ
-
STL
17h 10m
2 stops
$584Delta
Mon, Jun 29 - Wed, Jul 8
American Airlines Logo
5:21 pm - 12:57 pm
MCI
-
SDQ
18h 36m
1 stop
American Airlines Logo
7:00 am - 10:56 pm
SDQ
-
MCI
16h 56m
1 stop
$590American Airlines
Wed, Jul 22 - Wed, Jul 29
Delta Logo
6:00 am - 1:16 pm
STL
-
SDQ
6h 16m
1 stop
Delta Logo
2:42 pm - 10:15 pm
SDQ
-
STL
8h 33m
1 stop
$590Delta
Mon, Jun 29 - Wed, Jul 8
American Airlines Logo
5:04 pm - 9:27 am
MCI
-
SDQ
15h 23m
2 stops
American Airlines Logo
10:27 am - 10:24 pm
SDQ
-
MCI
12h 57m
2 stops
$595American Airlines
Mon, Jul 13 - Wed, Jul 22
American Airlines Logo
6:00 am - 6:44 pm
STL
-
SDQ
11h 44m
2 stops
American Airlines Logo
2:00 pm - 11:34 pm
SDQ
-
STL
10h 34m
1 stop
$595American Airlines
Tue, Aug 18 - Wed, Aug 26
Frontier Logo
5:06 pm - 11:06 am
STL
-
SDQ
41h 00m
2 stops
Frontier Logo
11:55 am - 6:18 pm
SDQ
-
STL
31h 23m
2 stops
$608Frontier
Wed, Jun 24 - Tue, Jun 30
American Airlines Logo
5:02 am - 1:09 pm
MCI
-
SDQ
7h 07m
1 stop
American Airlines Logo
10:27 am - 10:59 pm
SDQ
-
MCI
13h 32m
1 stop
$610American Airlines
Thu, Sep 10 - Mon, Sep 14
American Airlines Logo
5:48 pm - 12:57 pm
STL
-
SDQ
18h 09m
1 stop
American Airlines Logo
2:00 pm - 11:34 pm
SDQ
-
STL
10h 34m
1 stop
$610American Airlines
Mon, Jul 13 - Mon, Aug 10
American Airlines Logo
6:16 am - 6:34 pm
MCI
-
SDQ
11h 18m
2 stops
American Airlines Logo
4:20 pm - 11:48 am
SDQ
-
MCI
20h 28m
2 stops
$615American Airlines
Thu, Sep 10 - Mon, Sep 14

United Airlines flights from Missouri to Santo Domingo

Our best United Airlines deals on Missouri to Santo Domingo flight tickets
United Airlines
Jun 25
MCI6:05 amKansas City
15h 41m
1 stop
SDQ10:46 pmSanto Domingo Las Americas
Jun 29
SDQ3:20 pmSanto Domingo Las Americas
9h 39m
1 stop
MCI11:59 pmKansas City
$710
United Airlines
Oct 3
MCI9:59 amKansas City
24h 56m
2 stops
SDQ11:55 amSanto Domingo Las Americas
Oct 7
SDQ6:00 amSanto Domingo Las Americas
18h 52m
1 stop
MCI11:52 pmKansas City
$735
United Airlines
Jun 16
STL6:00 amLambert-St Louis
15h 46m
1 stop
SDQ10:46 pmSanto Domingo Las Americas
Jun 22
SDQ3:20 pmSanto Domingo Las Americas
9h 15m
1 stop
STL11:35 pmLambert-St Louis
$740

American Airlines flights from Missouri to Santo Domingo

Our best American Airlines deals on Missouri to Santo Domingo flight tickets
American Airlines
Jul 22
MCI5:21 pmKansas City
18h 36m
1 stop
SDQ12:57 pmSanto Domingo Las Americas
Jul 29
SDQ7:00 amSanto Domingo Las Americas
16h 56m
1 stop
MCI10:56 pmKansas City
$590
American Airlines
Jul 13
MCI5:21 pmKansas City
18h 36m
1 stop
SDQ12:57 pmSanto Domingo Las Americas
Jul 22
SDQ10:27 amSanto Domingo Las Americas
12h 57m
2 stops
MCI10:24 pmKansas City
$595
American Airlines
Sep 10
MCI5:02 amKansas City
7h 07m
1 stop
SDQ1:09 pmSanto Domingo Las Americas
Sep 14
SDQ10:27 amSanto Domingo Las Americas
13h 32m
1 stop
MCI10:59 pmKansas City
$610

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 4, 2026.
Use the filters below to find and compare flights from Missouri to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 8/18

3:33 pm-11:06 am

2 stops42h 33m

Santo Domingo Las Americas

Wed 8/26

12:21 pm-5:30 pm

2 stops30h 09m

$532

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 6/29

6:00 am-1:16 pm

1 stop6h 16m

Santo Domingo Las Americas

Wed 7/8

6:05 am-10:15 pm

2 stops17h 10m

$584

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Wed 7/22

5:21 pm-12:57 pm

1 stop18h 36m

Santo Domingo Las Americas

Wed 7/29

7:00 am-10:56 pm

1 stop16h 56m

$590
Quickest round-trip

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 6/29

6:00 am-1:16 pm

1 stop6h 16m

Santo Domingo Las Americas

Wed 7/8

2:42 pm-10:15 pm

1 stop8h 33m

$590

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 7/13

5:04 pm-9:27 am

2 stops15h 23m

Santo Domingo Las Americas

Wed 7/22

10:27 am-10:24 pm

2 stops12h 57m

$595

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 8/18

6:00 am-6:44 pm

2 stops11h 44m

Santo Domingo Las Americas

Wed 8/26

2:00 pm-11:34 pm

1 stop10h 34m

$595

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 6/24

5:06 pm-11:06 am

2 stops41h 00m

Santo Domingo Las Americas

Tue 6/30

11:55 am-6:18 pm

2 stops31h 23m

$608

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Thu 9/10

5:02 am-1:09 pm

1 stop7h 07m

Santo Domingo Las Americas

Mon 9/14

10:27 am-10:59 pm

1 stop13h 32m

$610

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 7/13

5:48 pm-12:57 pm

1 stop18h 09m

Santo Domingo Las Americas

Mon 8/10

2:00 pm-11:34 pm

1 stop10h 34m

$610

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Thu 9/10

6:16 am-6:34 pm

2 stops11h 18m

Santo Domingo Las Americas

Mon 9/14

4:20 pm-11:48 am

2 stops20h 28m

$615

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Missouri to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in June, then you should wait until April to fly from Missouri, when ticket prices are also cheap, with an average price of $314.

Can stopping save me money on Missouri to Santo Domingo flights?

You could potentially save up to 28% on your flight if you consider stops on a Missouri to Santo Domingo flight.

Cheap Missouri to Santo Domingo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Santo Domingo

Fastest flight time

6h 17m

Direct flights

None
The fastest flight from Missouri to Santo Domingo takes 6h 17m
There are no direct flights from Missouri to Santo Domingo. There are no popular flight routes from Missouri to Santo Domingo.
Search flight deals

Frequently asked questions about flying from Missouri to Santo Domingo

  • When did momondo last update prices for flights from Missouri to Santo Domingo Las Americas Airport?

    Prices for flights from Missouri to Santo Domingo Las Americas Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Missouri to Santo Domingo Las Americas Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Santo Domingo

Compare and see reviews for airlines that fly from Missouri to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $518Free CancellationRating
7.8
8,398 reviews
Search Delta flights
American AirlinesPriceFrom $521Free CancellationRating
7.1
11,643 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Santo Domingo?

It is quick and easy to find Missouri to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Missouri to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Missouri which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Missouri to Santo Domingo?

Once all potential Missouri to Santo Domingo flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Missouri to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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