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Cheap flights from Missouri to Santo Domingo from $158

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Santo Domingo departing on 2/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missouri to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:26 am - 2:27 pm
MCI
-
SDQ
25h 01m1 stop
Multiple Airlines Logo
4:42 pm - 10:26 am
SDQ
-
MCI
19h 44m1 stop
$334Multiple Airlines
Thu, Jan 8 - Thu, Jan 15
Multiple Airlines Logo
11:26 am - 2:27 pm
MCI
-
SDQ
25h 01m1 stop
Multiple Airlines Logo
4:42 pm - 10:31 am
SDQ
-
MCI
19h 49m2 stops
$350Multiple Airlines
Thu, Jan 8 - Thu, Jan 15
Multiple Airlines Logo
5:04 pm - 9:59 am
MCI
-
SDQ
14h 55m1 stop
Multiple Airlines Logo
3:32 pm - 10:31 am
SDQ
-
MCI
20h 59m1 stop
$363Multiple Airlines
Sat, Jan 24 - Sun, Jan 25
Multiple Airlines Logo
11:26 am - 3:35 pm
MCI
-
SDQ
26h 09m1 stop
Multiple Airlines Logo
3:35 pm - 4:50 pm
SDQ
-
MCI
27h 15m2 stops
$366Multiple Airlines
Mon, Feb 9 - Tue, Feb 17
Spirit Airlines Logo
6:15 pm - 2:54 am
MCI
-
SDQ
6h 39m1 stop
Spirit Airlines Logo
3:59 am - 5:10 pm
SDQ
-
MCI
15h 11m1 stop
$376Spirit Airlines
Mon, Dec 29 - Tue, Dec 30
Spirit Airlines Logo
6:15 pm - 2:54 am
MCI
-
SDQ
6h 39m1 stop
Spirit Airlines Logo
3:59 am - 10:59 pm
SDQ
-
MCI
21h 00m2 stops
$434Spirit Airlines
Mon, Dec 29 - Tue, Dec 30
Frontier Logo
11:38 am - 12:55 pm
MCI
-
SDQ
23h 17m2 stops
Frontier Logo
4:43 pm - 8:47 am
SDQ
-
MCI
18h 04m2 stops
$483Frontier
Mon, Jan 5 - Sat, Jan 10
American Airlines Logo
5:05 am - 5:23 pm
STL
-
SDQ
10h 18m1 stop
American Airlines Logo
7:00 am - 10:05 pm
SDQ
-
STL
17h 05m1 stop
$518American Airlines
Tue, Feb 3 - Tue, Feb 24
Delta Logo
6:35 am - 7:14 pm
STL
-
SDQ
10h 39m2 stops
Delta Logo
7:30 am - 8:43 pm
SDQ
-
STL
15h 13m2 stops
$522Delta
Tue, Feb 3 - Tue, Feb 24
American Airlines Logo
10:53 am - 7:55 pm
STL
-
SDQ
8h 02m1 stop
American Airlines Logo
5:00 pm - 11:59 pm
SDQ
-
STL
7h 59m1 stop
$533American Airlines
Wed, Jun 3 - Sun, Jun 7

United Airlines flights from Missouri to Santo Domingo

Our best United Airlines deals on Missouri to Santo Domingo flight tickets
United Airlines
Mar 22
MCI8:00 amKansas City
13h 46m
2 stops
SDQ10:46 pmSanto Domingo Las Americas
Mar 30
SDQ1:10 pmSanto Domingo Las Americas
10h 19m
1 stop
MCI10:29 pmKansas City
$581
Find similar
United Airlines
Feb 2
MCI8:00 amKansas City
13h 46m
2 stops
SDQ11:46 pmSanto Domingo Las Americas
Feb 5
SDQ4:18 pmSanto Domingo Las Americas
20h 14m
2 stops
MCI10:32 amKansas City
$640
Find similar
United Airlines
Feb 1
STL9:57 amLambert-St Louis
11h 49m
2 stops
SDQ11:46 pmSanto Domingo Las Americas
Feb 5
SDQ2:53 pmSanto Domingo Las Americas
11h 06m
1 stop
STL11:59 pmLambert-St Louis
$682
Find similar

American Airlines flights from Missouri to Santo Domingo

Our best American Airlines deals on Missouri to Santo Domingo flight tickets
American Airlines
Feb 3
STL5:05 amLambert-St Louis
10h 18m
1 stop
SDQ5:23 pmSanto Domingo Las Americas
Feb 24
SDQ7:00 amSanto Domingo Las Americas
17h 05m
1 stop
STL10:05 pmLambert-St Louis
$518
Find similar
American Airlines
Jan 8
MCI6:00 amKansas City
14h 39m
2 stops
SDQ10:39 pmSanto Domingo Las Americas
Jan 15
SDQ6:29 pmSanto Domingo Las Americas
16h 14m
2 stops
MCI8:43 amKansas City
$526
Find similar
American Airlines
Jun 3
STL10:53 amLambert-St Louis
8h 02m
1 stop
SDQ7:55 pmSanto Domingo Las Americas
Jun 7
SDQ5:00 pmSanto Domingo Las Americas
7h 59m
1 stop
STL11:59 pmLambert-St Louis
$533
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Missouri to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Thu 1/8

11:26 am-2:27 pm

1 stop25h 01m

Santo Domingo Las Americas

Thu 1/15

4:42 pm-10:26 am

1 stop19h 44m

$334

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Thu 1/8

11:26 am-2:27 pm

1 stop25h 01m

Santo Domingo Las Americas

Thu 1/15

4:42 pm-10:31 am

2 stops19h 49m

$350

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Sat 1/24

5:04 pm-9:59 am

1 stop14h 55m

Santo Domingo Las Americas

Sun 1/25

3:32 pm-10:31 am

1 stop20h 59m

$363

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 2/9

11:26 am-3:35 pm

1 stop26h 09m

Santo Domingo Las Americas

Tue 2/17

3:35 pm-4:50 pm

2 stops27h 15m

$366

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 12/29

6:15 pm-2:54 am

1 stop6h 39m

Santo Domingo Las Americas

Tue 12/30

3:59 am-5:10 pm

1 stop15h 11m

$376

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 12/29

6:15 pm-2:54 am

1 stop6h 39m

Santo Domingo Las Americas

Tue 12/30

3:59 am-10:59 pm

2 stops21h 00m

$434

Kansas CitySanto Domingo

MCI - SDQ

MCISDQ

Kansas City

Mon 1/5

11:38 am-12:55 pm

2 stops23h 17m

Santo Domingo Las Americas

Sat 1/10

4:43 pm-8:47 am

2 stops18h 04m

$483

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 2/3

5:05 am-5:23 pm

1 stop10h 18m

Santo Domingo Las Americas

Tue 2/24

7:00 am-10:05 pm

1 stop17h 05m

$518

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 2/3

6:35 am-7:14 pm

2 stops10h 39m

Santo Domingo Las Americas

Tue 2/24

7:30 am-8:43 pm

2 stops15h 13m

$522

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Wed 6/3

10:53 am-7:55 pm

1 stop8h 02m

Santo Domingo Las Americas

Sun 6/7

5:00 pm-11:59 pm

1 stop7h 59m

$533

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Missouri to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santo Domingo?

If you don’t want to visit Santo Domingo in March, then you should wait until September to fly from Missouri, when ticket prices are also cheap, with an average price of $533.

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Wednesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $486. The most expensive day to fly to Santo Domingo is Friday, with ticket prices averaging around $765.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the afternoon when flights can be purchased for as low as $445. Try not to purchase tickets in the morning because they tend to be around $610. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Missouri to Santo Domingo flights?

You could potentially save up to 35% on your flight if you consider stops on a Missouri to Santo Domingo flight.

Cheap Missouri to Santo Domingo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Santo Domingo

Fastest flight time

6h 15m

Direct flights

None
The fastest flight from Missouri to Santo Domingo takes 6h 15m
There are no direct flights from Missouri to Santo Domingo. There are no popular flight routes from Missouri to Santo Domingo.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Santo Domingo Las Americas Airport?

    Prices for flights from Missouri to Santo Domingo Las Americas Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Missouri to Santo Domingo Las Americas Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The travel and health documents required for your trip to Santo Domingo Las Americas Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santo Domingo Las Americas Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Santo Domingo

Compare and see reviews for airlines that fly from Missouri to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $262Free CancellationRating
7.9
8,008 reviews
Search Delta flights
American AirlinesPriceFrom $492Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Santo Domingo?

It is quick and easy to find Missouri to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Missouri to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Missouri which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Missouri to Santo Domingo?

Once all potential Missouri to Santo Domingo flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Missouri to Santo Domingo right now. Can momondo alert me if prices change?

Price alerts on flights to Santo Domingo from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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