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Cheap flights from Mexico City to Santiago from $280

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mexico City to Santiago departing on 9/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Mexico City to Santiago

Cheap round-trip flights

Avianca Logo
12:40 am - 11:30 pmMEX-SCL
19h 50m1 stop
Avianca Logo
3:30 pm - 3:05 amSCL-MEX
14h 35m1 stop
$533Avianca
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Wed, Oct 8 - Wed, Oct 22
Copa Airlines Logo
1:05 pm - 8:20 pmMEX-SCL
28h 15m1 stop
Copa Airlines Logo
3:35 am - 12:10 pmSCL-MEX
11h 35m1 stop
$553Copa Airlines
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Wed, Sep 24 - Tue, Sep 30
LATAM Airlines Logo
7:50 pm - 6:55 amMEX-SCL
8h 05mnonstop
LATAM Airlines Logo
9:15 am - 2:55 pmSCL-MEX
8h 40mnonstop
$554LATAM Airlines
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Mon, Nov 17 - Fri, Nov 28
Avianca Logo
12:40 am - 11:30 pmMEX-SCL
19h 50m1 stop
Avianca Logo
3:30 pm - 12:05 pmSCL-MEX
23h 35m1 stop
$561Avianca
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Tue, Sep 16 - Wed, Sep 24
Copa Airlines Logo
1:40 am - 8:20 pmMEX-SCL
15h 40m1 stop
Copa Airlines Logo
3:35 am - 10:05 pmSCL-MEX
21h 30m1 stop
$563Copa Airlines
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Mon, Oct 6 - Mon, Oct 13
LATAM Airlines Logo
4:00 pm - 5:50 amMEX-SCL
10h 50m1 stop
LATAM Airlines Logo
5:15 am - 1:50 pmSCL-MEX
11h 35m1 stop
$580LATAM Airlines
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Thu, Dec 4 - Wed, Dec 17
Logo
6:55 pm - 2:05 pmMEX-SCL
16h 10m2 stops
Logo
1:35 am - 12:10 pmSCL-MEX
13h 35m1 stop
$594
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Wed, Nov 5 - Sun, Nov 9
Aeromexico Logo
10:00 am - 9:15 pmMEX-SCL
8h 15mnonstop
Aeromexico Logo
11:25 pm - 5:05 amSCL-MEX
8h 40mnonstop
$601Aeromexico
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Mon, Nov 3 - Wed, Dec 24
Logo
5:35 pm - 10:00 pmMEX-SCL
25h 25m1 stop
Logo
9:15 am - 2:55 pmSCL-MEX
8h 40mnonstop
$613
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Sat, Nov 29 - Sun, Dec 7
Aeromexico Logo
10:00 am - 9:15 pmMEX-SCL
8h 15mnonstop
Aeromexico Logo
11:25 pm - 5:05 amSCL-MEX
8h 40mnonstop
$627Aeromexico
Find Deal
Mon, Nov 3 - Sun, Dec 28

Copa Airlines flights from Mexico City to Santiago

Our best Copa Airlines deals on Mexico City to Santiago flight tickets
Copa Airlines
Sep 24
MEX1:05 pmMexico City Benito Juarez
28h 15m
1 stop
SCL8:20 pmSantiago Arturo Merino Benitez
Sep 30
SCL3:35 amSantiago Arturo Merino Benitez
11h 35m
1 stop
MEX12:10 pmMexico City Benito Juarez
$553
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Copa Airlines
Oct 6
MEX1:40 amMexico City Benito Juarez
15h 40m
1 stop
SCL8:20 pmSantiago Arturo Merino Benitez
Oct 13
SCL3:35 amSantiago Arturo Merino Benitez
21h 30m
1 stop
MEX10:05 pmMexico City Benito Juarez
$563
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Copa Airlines
Sep 22
MEX9:50 amMexico City Benito Juarez
17h 08m
1 stop
SCL5:58 amSantiago Arturo Merino Benitez
Sep 28
SCL3:26 amSantiago Arturo Merino Benitez
14h 04m
1 stop
MEX2:30 pmMexico City Benito Juarez
$584
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Avianca flights from Mexico City to Santiago

Our best Avianca deals on Mexico City to Santiago flight tickets
Avianca
Oct 8
MEX12:40 amMexico City Benito Juarez
19h 50m
1 stop
SCL11:30 pmSantiago Arturo Merino Benitez
Oct 22
SCL3:30 pmSantiago Arturo Merino Benitez
14h 35m
1 stop
MEX3:05 amMexico City Benito Juarez
$533
Find similar
Avianca
Sep 16
MEX12:40 amMexico City Benito Juarez
19h 50m
1 stop
SCL11:30 pmSantiago Arturo Merino Benitez
Sep 24
SCL3:30 pmSantiago Arturo Merino Benitez
23h 35m
1 stop
MEX12:05 pmMexico City Benito Juarez
$561
Find similar
Avianca
Nov 5
MEX1:50 pmMexico City Benito Juarez
12h 40m
1 stop
SCL5:30 amSantiago Arturo Merino Benitez
Nov 10
SCL4:25 pmSantiago Arturo Merino Benitez
13h 35m
1 stop
MEX3:00 amMexico City Benito Juarez
$570
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momondo Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 25, 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 10/8

12:40 am-11:30 pm

1 stop19h 50m

Santiago Arturo Merino Benitez

Wed 10/22

3:30 pm-3:05 am

1 stop14h 35m

$533

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 9/24

1:05 pm-8:20 pm

1 stop28h 15m

Santiago Arturo Merino Benitez

Tue 9/30

3:35 am-12:10 pm

1 stop11h 35m

$553

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 11/17

7:50 pm-6:55 am

Nonstop8h 05m

Santiago Arturo Merino Benitez

Fri 11/28

9:15 am-2:55 pm

Nonstop8h 40m

$554

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 9/16

12:40 am-11:30 pm

1 stop19h 50m

Santiago Arturo Merino Benitez

Wed 9/24

3:30 pm-12:05 pm

1 stop23h 35m

$561

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 10/6

1:40 am-8:20 pm

1 stop15h 40m

Santiago Arturo Merino Benitez

Mon 10/13

3:35 am-10:05 pm

1 stop21h 30m

$563

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 12/4

4:00 pm-5:50 am

1 stop10h 50m

Santiago Arturo Merino Benitez

Wed 12/17

5:15 am-1:50 pm

1 stop11h 35m

$580

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 11/5

6:55 pm-2:05 pm

2 stops16h 10m

Santiago Arturo Merino Benitez

Sun 11/9

1:35 am-12:10 pm

1 stop13h 35m

$594

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 11/3

10:00 am-9:15 pm

Nonstop8h 15m

Santiago Arturo Merino Benitez

Wed 12/24

11:25 pm-5:05 am

Nonstop8h 40m

$601

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 11/29

5:35 pm-10:00 pm

1 stop25h 25m

Santiago Arturo Merino Benitez

Sun 12/7

9:15 am-2:55 pm

Nonstop8h 40m

$613

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 11/3

10:00 am-9:15 pm

Nonstop8h 15m

Santiago Arturo Merino Benitez

Sun 12/28

11:25 pm-5:05 am

Nonstop8h 40m

$627

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Mexico City to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, May is the cheapest month to fly from Mexico City to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $536. If you don’t want to visit Santiago in May, then you should wait until July to fly from Mexico City, when ticket prices are also cheap, with an average price of $586.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Thursday when prices can be found for as low as $680. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $976.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Mexico City to Santiago when you can find flight prices for as low as $592. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $891 per ticket.

What is the cheapest Mexico City Benito Juarez to Santiago Arturo Merino Benitez flight route?

Fly from Mexico City Benito Juarez to Santiago Arturo Merino Benitez for the best Mexico City Benito Juarez - Santiago Arturo Merino Benitez flight prices

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $629 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Mexico City for as low as $547 on momondo.

What cabin class options are available on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights?

There are 3 cabin classes available to choose from on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Mexico City to Santiago flights?

You could potentially save up to 4% on your flight if you consider stops on a Mexico City to Santiago flight.

How have Mexico City to Santiago flight prices changed over time?

As of August 2025, prices for Mexico City to Santiago flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from Mexico City to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Mexico City to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Mexico City to Santiago (MEX to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mexico City to Santiago

Best Price Found

$582

Fastest flight time

8h 05m

Direct flights

Every day

Airports in Santiago

1 airport
The best one-way flight to Santiago from Mexico City in the past 72 hours is $582. The best round-trip flight deal from Mexico City to Santiago found on momondo in the last 72 hours is $619.
The fastest flight from Mexico City to Santiago takes 8h 05m
Direct flights go from Mexico City to Santiago every day.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
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  • How far is Mexico City Benito Juarez to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Mexico City Benito Juarez to Santiago Arturo Merino Benitez is 4104.7 mi. In terms of flight time, this usually takes a little over 8h 05m.

  • When did momondo last update prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Mexico City to Santiago?

  • What is the most popular airline from Mexico City to Santiago?

Best airlines flying from Mexico City to Santiago

Compare and see reviews for airlines that fly from Mexico City to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $314Free CancellationRating
7.5
1,514 reviews
Search Copa Airlines flights
AviancaPriceFrom $330Free CancellationRating
6.7
2,417 reviews
Search Avianca flights
AeromexicoPriceFrom $384Free CancellationRating
7.4
1,711 reviews
Search Aeromexico flights
LATAM AirlinesPriceFrom $491Free CancellationRating
7.5
1,843 reviews
Search LATAM Airlines flights

  • LATAM Airlines Flights From Mexico City to Santiago

    LATAM Airlines flies from Mexico City to Santiago around 9 times per week, with 1,843 momondo users rating the airline 7.5/10. The cheapest LATAM Airlines deal from Mexico City to Santiago in the last 72 hours was $491 (round-trip), much lower than the average airfare cost of $675 for LATAM Airlines flights on this route.

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Mexico City to Santiago?

Finding the right flight to Santiago from Mexico City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from Mexico City to Santiago with flexible booking policies on momondo?

All flight searches from Mexico City to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Mexico City to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Mexico City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mexico City to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Mexico City to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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