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Cheap flights from Mexico City to Santiago from $282

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mexico City to Santiago departing on 12/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Mexico City to Santiago

Cheap round-trip flights

Logo
12:40 am - 12:00 pmMEX-SCL
32h 20m3 stops
Logo
7:10 am - 11:00 pmSCL-MEX
18h 50m1 stop
$538
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Tue, Sep 23 - Fri, Oct 10
Logo
12:40 am - 12:00 pmMEX-SCL
32h 20m3 stops
Logo
12:55 am - 12:05 pmSCL-MEX
14h 10m1 stop
$552
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Tue, Sep 23 - Thu, Oct 9
LATAM Airlines Logo
3:10 pm - 4:45 amMEX-SCL
11h 35m1 stop
LATAM Airlines Logo
9:30 pm - 3:35 pmSCL-MEX
21h 05m1 stop
$554LATAM Airlines
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Mon, Sep 1 - Thu, Sep 25
Avianca Logo
12:40 am - 11:30 pmMEX-SCL
19h 50m1 stop
Avianca Logo
3:30 pm - 3:05 amSCL-MEX
14h 35m1 stop
$555Avianca
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Wed, Oct 8 - Wed, Oct 22
Copa Airlines Logo
3:30 pm - 5:02 amMEX-SCL
11h 32m1 stop
Copa Airlines Logo
12:24 am - 12:10 pmSCL-MEX
13h 46m1 stop
$558Copa Airlines
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Thu, Aug 21 - Tue, Aug 26
Copa Airlines Logo
1:05 pm - 2:46 amMEX-SCL
11h 41m1 stop
Copa Airlines Logo
4:11 am - 12:15 amSCL-MEX
22h 04m1 stop
$560Copa Airlines
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Wed, Aug 6 - Wed, Aug 13
Copa Airlines Logo
1:40 am - 10:44 pmMEX-SCL
19h 04m1 stop
Copa Airlines Logo
4:11 am - 2:30 pmSCL-MEX
12h 19m1 stop
$561Copa Airlines
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Tue, Aug 5 - Wed, Aug 13
Avianca Logo
2:00 pm - 5:15 amMEX-SCL
12h 15m1 stop
Avianca Logo
3:30 pm - 3:05 amSCL-MEX
14h 35m1 stop
$571Avianca
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Thu, Oct 9 - Mon, Oct 13
LATAM Airlines Logo
8:00 pm - 7:40 amMEX-SCL
8h 40mnonstop
LATAM Airlines Logo
8:50 pm - 1:50 pmSCL-MEX
20h 00m1 stop
$573LATAM Airlines
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Tue, Oct 21 - Fri, Oct 31
Aeromexico Logo
10:00 am - 9:15 pmMEX-SCL
8h 15mnonstop
Aeromexico Logo
11:25 pm - 5:05 amSCL-MEX
8h 40mnonstop
$600Aeromexico
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Mon, Nov 17 - Fri, Nov 28

LATAM Airlines flights from Mexico City to Santiago

Our best LATAM Airlines deals on Mexico City to Santiago flight tickets
LATAM Airlines
Sep 1
MEX3:10 pmMexico City Benito Juarez
11h 35m
1 stop
SCL4:45 amSantiago Arturo Merino Benitez
Sep 25
SCL9:30 pmSantiago Arturo Merino Benitez
21h 05m
1 stop
MEX3:35 pmMexico City Benito Juarez
$554
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LATAM Airlines
Oct 21
MEX8:00 pmMexico City Benito Juarez
8h 40m
SCL7:40 amSantiago Arturo Merino Benitez
Oct 31
SCL8:50 pmSantiago Arturo Merino Benitez
20h 00m
1 stop
MEX1:50 pmMexico City Benito Juarez
$573
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LATAM Airlines
Nov 17
MEX7:00 pmMexico City Benito Juarez
16h 05m
2 stops
SCL2:05 pmSantiago Arturo Merino Benitez
Nov 27
SCL4:35 amSantiago Arturo Merino Benitez
12h 15m
1 stop
MEX1:50 pmMexico City Benito Juarez
$599
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Avianca flights from Mexico City to Santiago

Our best Avianca deals on Mexico City to Santiago flight tickets
Avianca
Oct 8
MEX12:40 amMexico City Benito Juarez
19h 50m
1 stop
SCL11:30 pmSantiago Arturo Merino Benitez
Oct 22
SCL3:30 pmSantiago Arturo Merino Benitez
14h 35m
1 stop
MEX3:05 amMexico City Benito Juarez
$555
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Avianca
Oct 9
MEX2:00 pmMexico City Benito Juarez
12h 15m
1 stop
SCL5:15 amSantiago Arturo Merino Benitez
Oct 13
SCL3:30 pmSantiago Arturo Merino Benitez
14h 35m
1 stop
MEX3:05 amMexico City Benito Juarez
$571
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Avianca
Sep 4
MEX2:00 pmMexico City Benito Juarez
21h 25m
1 stop
SCL1:25 pmSantiago Arturo Merino Benitez
Sep 21
SCL12:55 amSantiago Arturo Merino Benitez
25h 05m
1 stop
MEX11:00 pmMexico City Benito Juarez
$585
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See travel insights to Santiago from

How to get the cheapest flight ticket from Mexico City to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, May is the cheapest month to fly from Mexico City to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $537. If you don’t want to visit Santiago in May, then you should wait until March to fly from Mexico City, when ticket prices are also cheap, with an average price of $587.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Thursday when prices can be found for as low as $640. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $1,018.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Mexico City to Santiago when you can find flight prices for as low as $592. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $787 per ticket.

What is the cheapest Mexico City Benito Juarez to Santiago Arturo Merino Benitez flight route?

Fly from Mexico City Benito Juarez to Santiago Arturo Merino Benitez for the best Mexico City Benito Juarez - Santiago Arturo Merino Benitez flight prices

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $634 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Mexico City for as low as $566 on momondo.

What cabin class options are available on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights?

There are 3 cabin classes available to choose from on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Mexico City to Santiago flights?

You could potentially save up to 21% on your flight if you consider stops on a Mexico City to Santiago flight.

How have Mexico City to Santiago flight prices changed over time?

As of July 2025, prices for Mexico City to Santiago flights are approximately 15% cheaper when compared to flights at the same time last year.

When to book flights from Mexico City to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Mexico City to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Mexico City to Santiago (MEX to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mexico City to Santiago

Best Price Found

$282

Fastest flight time

8h 05m

Direct flights

Every day

Airports in Santiago

1 airport
The best one-way flight to Santiago from Mexico City in the past 72 hours is $282. The best round-trip flight deal from Mexico City to Santiago found on momondo in the last 72 hours is $538.
The fastest flight from Mexico City to Santiago takes 8h 05m
Direct flights go from Mexico City to Santiago every day.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
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  • How far is Mexico City Benito Juarez to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Mexico City Benito Juarez to Santiago Arturo Merino Benitez is 4104.7 mi. In terms of flight time, this usually takes a little over 8h 05m.

  • When did momondo last update prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Mexico City to Santiago?

  • What is the most popular airline from Mexico City to Santiago?

Best airlines flying from Mexico City to Santiago

Compare and see reviews for airlines that fly from Mexico City to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $314Free CancellationRating
7.5
1,474 reviews
Search Copa Airlines flights
AviancaPriceFrom $330Free CancellationRating
6.7
2,374 reviews
Search Avianca flights
AeromexicoPriceFrom $384Free CancellationRating
7.5
1,719 reviews
Search Aeromexico flights
LATAM AirlinesPriceFrom $500Free CancellationRating
7.5
1,807 reviews
Search LATAM Airlines flights

  • LATAM Airlines Flights From Mexico City to Santiago

    LATAM Airlines flies from Mexico City to Santiago around 4 times per week, with 1,807 momondo users rating the airline 7.5/10. The cheapest LATAM Airlines deal from Mexico City to Santiago in the last 72 hours was $500 (round-trip), much lower than the average airfare cost of $684 for LATAM Airlines flights on this route.

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Mexico City to Santiago?

Finding the right flight to Santiago from Mexico City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from Mexico City to Santiago with flexible booking policies on momondo?

All flight searches from Mexico City to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Mexico City to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Mexico City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mexico City to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Mexico City to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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