Cheap flights from Mexico City to Santiago from $248

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mexico City to Santiago departing on 1/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
Multiple Airlines Logo
9:30 am - 9:20 pm
SCL
-
MEX
14h 50m1 stop
$518Multiple Airlines
Wed, Mar 4 - Fri, Mar 20
LATAM Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
LATAM Airlines Logo
4:35 am - 1:50 pm
SCL
-
MEX
12h 15m1 stop
$522LATAM Airlines
Mon, Mar 2 - Wed, Mar 11
LATAM Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
LATAM Airlines Logo
4:35 am - 1:50 pm
SCL
-
MEX
12h 15m1 stop
$526LATAM Airlines
Thu, Jan 22 - Wed, Jan 28
Multiple Airlines Logo
12:40 am - 3:20 pm
MEX
-
SCL
11h 40m1 stop
Multiple Airlines Logo
9:29 pm - 11:10 am
SCL
-
MEX
16h 41m1 stop
$532Multiple Airlines
Wed, Jan 21 - Mon, Feb 16
Multiple Airlines Logo
12:40 am - 3:20 pm
MEX
-
SCL
11h 40m1 stop
Multiple Airlines Logo
9:29 pm - 11:10 am
SCL
-
MEX
16h 41m1 stop
$534Multiple Airlines
Wed, Jan 21 - Tue, Feb 17
Multiple Airlines Logo
12:40 am - 3:20 pm
MEX
-
SCL
11h 40m1 stop
Multiple Airlines Logo
9:29 pm - 11:10 am
SCL
-
MEX
16h 41m1 stop
$542Multiple Airlines
Mon, Jan 19 - Tue, Feb 17
Multiple Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
Multiple Airlines Logo
9:39 pm - 11:10 am
SCL
-
MEX
16h 31m1 stop
$543Multiple Airlines
Wed, Jan 21 - Wed, Feb 18
Multiple Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
Multiple Airlines Logo
9:30 am - 9:15 pm
SCL
-
MEX
14h 45m1 stop
$544Multiple Airlines
Fri, Mar 20 - Fri, Mar 27
Multiple Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
Multiple Airlines Logo
9:29 pm - 11:10 am
SCL
-
MEX
16h 41m1 stop
$545Multiple Airlines
Wed, Jan 21 - Tue, Feb 17
LATAM Airlines Logo
4:00 pm - 5:50 am
MEX
-
SCL
10h 50m1 stop
LATAM Airlines Logo
4:35 am - 1:50 pm
SCL
-
MEX
12h 15m1 stop
$547LATAM Airlines
Tue, Jan 27 - Wed, Feb 18

LATAM Airlines flights from Mexico City to Santiago

Our best LATAM Airlines deals on Mexico City to Santiago flight tickets
LATAM Airlines
Mar 2
MEX7:50 pmMexico City Benito Juarez
8h 40m
SCL7:30 amSantiago Arturo Merino Benitez
Mar 11
SCL9:00 amSantiago Arturo Merino Benitez
8h 50m
MEX2:50 pmMexico City Benito Juarez
$522
LATAM Airlines
Jan 22
MEX7:50 pmMexico City Benito Juarez
8h 40m
SCL7:30 amSantiago Arturo Merino Benitez
Jan 28
SCL4:35 amSantiago Arturo Merino Benitez
12h 15m
1 stop
MEX1:50 pmMexico City Benito Juarez
$526
LATAM Airlines
Jan 27
MEX4:00 pmMexico City Benito Juarez
10h 50m
1 stop
SCL5:50 amSantiago Arturo Merino Benitez
Feb 18
SCL4:35 amSantiago Arturo Merino Benitez
12h 15m
1 stop
MEX1:50 pmMexico City Benito Juarez
$547

Copa Airlines flights from Mexico City to Santiago

Our best Copa Airlines deals on Mexico City to Santiago flight tickets
Copa Airlines
Jan 26
MEX1:10 pmMexico City Benito Juarez
12h 04m
1 stop
SCL4:14 amSantiago Arturo Merino Benitez
Feb 17
SCL12:28 pmSantiago Arturo Merino Benitez
12h 37m
1 stop
MEX10:05 pmMexico City Benito Juarez
$551
Copa Airlines
Jan 26
MEX9:25 amMexico City Benito Juarez
11h 18m
1 stop
SCL11:43 pmSantiago Arturo Merino Benitez
Feb 16
SCL5:44 amSantiago Arturo Merino Benitez
16h 36m
1 stop
MEX7:20 pmMexico City Benito Juarez
$573
Copa Airlines
Jan 26
MEX9:25 amMexico City Benito Juarez
11h 18m
1 stop
SCL11:43 pmSantiago Arturo Merino Benitez
Feb 20
SCL12:28 pmSantiago Arturo Merino Benitez
14h 47m
1 stop
MEX12:15 amMexico City Benito Juarez
$578

momondo Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 3/4

7:50 pm-7:30 am

Nonstop8h 40m

Santiago Arturo Merino Benitez

Fri 3/20

9:30 am-9:20 pm

1 stop14h 50m

$518

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 3/2

7:50 pm-7:30 am

Nonstop8h 40m

Santiago Arturo Merino Benitez

Wed 3/11

4:35 am-1:50 pm

1 stop12h 15m

$522

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 1/22

7:50 pm-7:30 am

Nonstop8h 40m

Santiago Arturo Merino Benitez

Wed 1/28

4:35 am-1:50 pm

1 stop12h 15m

$526

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 1/21

12:40 am-3:20 pm

1 stop11h 40m

Santiago Arturo Merino Benitez

Mon 2/16

9:29 pm-11:10 am

1 stop16h 41m

$532

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 1/21

12:40 am-3:20 pm

1 stop11h 40m

Santiago Arturo Merino Benitez

Tue 2/17

9:29 pm-11:10 am

1 stop16h 41m

$534

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 1/19

12:40 am-3:20 pm

1 stop11h 40m

Santiago Arturo Merino Benitez

Tue 2/17

9:29 pm-11:10 am

1 stop16h 41m

$542

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 1/21

7:50 pm-7:30 am

Nonstop8h 40m

Santiago Arturo Merino Benitez

Wed 2/18

9:39 pm-11:10 am

1 stop16h 31m

$543

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 3/20

7:50 pm-7:30 am

Nonstop8h 40m

Santiago Arturo Merino Benitez

Fri 3/27

9:30 am-9:15 pm

1 stop14h 45m

$544

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 1/21

7:50 pm-7:30 am

Nonstop8h 40m

Santiago Arturo Merino Benitez

Tue 2/17

9:29 pm-11:10 am

1 stop16h 41m

$545

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 1/27

4:00 pm-5:50 am

1 stop10h 50m

Santiago Arturo Merino Benitez

Wed 2/18

4:35 am-1:50 pm

1 stop12h 15m

$547

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Mexico City to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Mexico City and Santiago?

What is the cheapest month to fly to Santiago?

In general, May is the cheapest month to fly from Mexico City to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $538. If you don’t want to visit Santiago in May, then you should wait until November to fly from Mexico City, when ticket prices are also cheap, with an average price of $562.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Monday when prices can be found for as low as $670. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $724.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from Mexico City to Santiago when you can find flight prices for as low as $687. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $699 per ticket.

What is the cheapest Mexico City Benito Juarez to Santiago Arturo Merino Benitez flight route?

Fly from Mexico City Benito Juarez to Santiago Arturo Merino Benitez for the best Mexico City Benito Juarez - Santiago Arturo Merino Benitez flight prices

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $609 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Mexico City for as low as $538 on momondo.

What cabin class options are available on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights?

There are 2 cabin classes available to choose from on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Mexico City to Santiago flights?

No. A direct flight is the cheapest option for a flight between Mexico City to Santiago.

How have Mexico City to Santiago flight prices changed over time?

As of January 2026, prices for Mexico City to Santiago flights are approximately 3% more expensive when compared to flights at the same time last year.

When to book flights from Mexico City to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Mexico City to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Mexico City to Santiago (MEX to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mexico City to Santiago

Best Price Found

$315

Fastest flight time

8h 00m

Direct flights

Every day

Airports in Santiago

1 airport
The best one-way flight to Santiago from Mexico City in the past 72 hours is $315. The best round-trip flight deal from Mexico City to Santiago found on momondo in the last 72 hours is $315.
The fastest flight from Mexico City to Santiago takes 8h 00m
Direct flights go from Mexico City to Santiago every day.
There is 1 airport in Santiago. From Mexico City there are direct flights to Santiago Arturo Merino Benitez (SCL).
  • How far is Mexico City Benito Juarez to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Mexico City Benito Juarez to Santiago Arturo Merino Benitez is 4104.7 mi. In terms of flight time, this usually takes a little over 8h 00m.

  • When did momondo last update prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Mexico City to Santiago?

  • What is the most popular airline from Mexico City to Santiago?

Best airlines flying from Mexico City to Santiago

Compare and see reviews for airlines that fly from Mexico City to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AeromexicoPriceFrom $303Free CancellationRating
7.4
1,606 reviews
Search Aeromexico flights
Copa AirlinesPriceFrom $423Free CancellationRating
7.6
1,562 reviews
Search Copa Airlines flights
AviancaPriceFrom $461Free CancellationRating
6.6
2,494 reviews
Search Avianca flights
LATAM AirlinesPriceFrom $474Free CancellationRating
7.5
1,898 reviews
Search LATAM Airlines flights
  • LATAM Airlines Flights From Mexico City to Santiago

    LATAM Airlines flies from Mexico City to Santiago around 5 times per week, with 1,898 momondo users rating the airline 7.5/10. The cheapest LATAM Airlines deal from Mexico City to Santiago in the last 72 hours was $474 (round-trip), much lower than the average airfare cost of $655 for LATAM Airlines flights on this route.

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Mexico City to Santiago?

Finding the right flight to Santiago from Mexico City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from Mexico City to Santiago with flexible booking policies on momondo?

All flight searches from Mexico City to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Mexico City to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Mexico City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mexico City to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Mexico City to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Sat 2/7
Sat 2/14

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