Cheap flights from Mexico City to Santiago from $303

In general, May is the cheapest month to fly from Mexico City to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $555. If you don’t want to visit Santiago in May, then you should wait until November to fly from Mexico City, when ticket prices are also cheap, with an average price of $567.

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $660. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Friday is $868.

In the morning is the cheapest time of day to fly from Mexico City to Santiago when you can find flight prices for as low as $679. Flying to Santiago in the morning is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $722 per ticket.

Fly from Mexico City Benito Juarez to Santiago Arturo Merino Benitez for the best Mexico City Benito Juarez - Santiago Arturo Merino Benitez flight prices

You are more likely to see cheaper flights to Santiago from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $625 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Mexico City for as low as $530 on momondo.

There are 2 cabin classes available to choose from on Mexico City to Santiago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Mexico City to Santiago.

As of April 2026, prices for Mexico City to Santiago flights are approximately 3% more expensive when compared to flights at the same time last year.

Historically, on average around 11% of flights between Mexico City and Santiago have experienced a delay on any given week. The average delay length over the past 12 months has been 121 minutes.

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights in the evening have, in the past, seen delays more frequently in comparison.

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Thursday has historically seen more delays on average compared to the rest of the week.

According to our data, Aeromexico have had the least number of delays on this route over the last 12 months; with about 9% of their flights experiencing any sort of delay.

Panama City (PTY) was the most common stop: 60% of momondo users choosing 1-stop flights on this route connected there.

Flights via Bogotá (BOG) offer the lowest average round-trip price of $571.

Flights connecting via Panama City (PTY) have the shortest average one-way travel time: 11h 20m.

Panama City (PTY) has the shortest average layover time for this route: 1h 10m.