Cheap flights from Mexico City to Santiago from $249

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mexico City to Santiago departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Multiple Airlines Logo
11:10 pm - 12:30 am
MEX
-
SCL
22h 20m
1 stop
Multiple Airlines Logo
11:24 am - 11:10 am
SCL
-
MEX
26h 46m
1 stop
$456Multiple Airlines
Wed, Mar 11 - Sun, Mar 22
Copa Airlines Logo
5:50 am - 7:23 pm
MEX
-
SCL
11h 33m
1 stop
Copa Airlines Logo
4:41 am - 2:30 pm
SCL
-
MEX
11h 49m
1 stop
$481Copa Airlines
Sun, Apr 26 - Fri, May 8
LATAM Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
LATAM Airlines Logo
4:35 am - 1:50 pm
SCL
-
MEX
12h 15m
1 stop
$500LATAM Airlines
Sat, Mar 7 - Sat, Mar 14
Avianca Logo
11:10 pm - 12:30 am
MEX
-
SCL
22h 20m
1 stop
Avianca Logo
1:35 am - 12:10 pm
SCL
-
MEX
13h 35m
1 stop
$501Avianca
Mon, Mar 9 - Thu, Mar 19
Copa Airlines Logo
5:50 am - 10:43 pm
MEX
-
SCL
14h 53m
1 stop
Copa Airlines Logo
11:17 am - 12:15 am
SCL
-
MEX
14h 58m
1 stop
$504Copa Airlines
Sun, Apr 26 - Sun, May 3
LATAM Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
LATAM Airlines Logo
5:15 am - 1:50 pm
SCL
-
MEX
11h 35m
1 stop
$516LATAM Airlines
Mon, Mar 9 - Fri, Mar 20
Copa Airlines Logo
5:55 am - 3:17 am
MEX
-
SCL
18h 22m
1 stop
Copa Airlines Logo
12:28 pm - 12:15 am
SCL
-
MEX
14h 47m
1 stop
$517Copa Airlines
Sun, Mar 15 - Sun, Mar 22
Avianca Logo
11:20 pm - 10:30 pm
MEX
-
SCL
21h 10m
1 stop
Avianca Logo
6:10 am - 11:00 pm
SCL
-
MEX
18h 50m
1 stop
$518Avianca
Sat, Apr 11 - Sat, Apr 18
Multiple Airlines Logo
4:50 pm - 10:39 am
MEX
-
SCL
14h 49m
2 stops
Multiple Airlines Logo
11:24 am - 11:10 am
SCL
-
MEX
26h 46m
1 stop
$524Multiple Airlines
Wed, Mar 11 - Sun, Mar 22
Copa Airlines Logo
5:50 am - 3:00 am
MEX
-
SCL
19h 10m
1 stop
Copa Airlines Logo
11:17 am - 1:00 am
SCL
-
MEX
15h 43m
1 stop
$525Copa Airlines
Fri, Jun 5 - Mon, Jun 22

Avianca flights from Mexico City to Santiago

Our best Avianca deals on Mexico City to Santiago flight tickets
Avianca
Mar 9
MEX11:10 pmMexico City Benito Juarez
22h 20m
1 stop
SCL12:30 amSantiago Arturo Merino Benitez
Mar 19
SCL1:35 amSantiago Arturo Merino Benitez
13h 35m
1 stop
MEX12:10 pmMexico City Benito Juarez
$501
Avianca
Apr 11
MEX11:20 pmMexico City Benito Juarez
21h 10m
1 stop
SCL10:30 pmSantiago Arturo Merino Benitez
Apr 18
SCL6:10 amSantiago Arturo Merino Benitez
18h 50m
1 stop
MEX11:00 pmMexico City Benito Juarez
$518
Avianca
May 7
MEX4:55 amMexico City Benito Juarez
15h 35m
1 stop
SCL10:30 pmSantiago Arturo Merino Benitez
May 11
SCL11:55 pmSantiago Arturo Merino Benitez
14h 10m
1 stop
MEX12:05 pmMexico City Benito Juarez
$550

LATAM Airlines flights from Mexico City to Santiago

Our best LATAM Airlines deals on Mexico City to Santiago flight tickets
LATAM Airlines
Mar 7
MEX7:50 pmMexico City Benito Juarez
8h 40m
SCL7:30 amSantiago Arturo Merino Benitez
Mar 14
SCL4:35 amSantiago Arturo Merino Benitez
12h 15m
1 stop
MEX1:50 pmMexico City Benito Juarez
$500
LATAM Airlines
Mar 9
MEX7:50 pmMexico City Benito Juarez
8h 40m
SCL7:30 amSantiago Arturo Merino Benitez
Mar 20
SCL5:15 amSantiago Arturo Merino Benitez
11h 35m
1 stop
MEX1:50 pmMexico City Benito Juarez
$516
LATAM Airlines
Mar 5
MEX7:50 pmMexico City Benito Juarez
8h 40m
SCL7:30 amSantiago Arturo Merino Benitez
Mar 12
SCL9:00 amSantiago Arturo Merino Benitez
9h 15m
MEX3:15 pmMexico City Benito Juarez
$568

momondo Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 3/11

11:10 pm-12:30 am

1 stop22h 20m

Santiago Arturo Merino Benitez

Sun 3/22

11:24 am-11:10 am

1 stop26h 46m

$456

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 4/26

5:50 am-7:23 pm

1 stop11h 33m

Santiago Arturo Merino Benitez

Fri 5/8

4:41 am-2:30 pm

1 stop11h 49m

$481

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 3/7

7:50 pm-7:30 am

Nonstop8h 40m

Santiago Arturo Merino Benitez

Sat 3/14

4:35 am-1:50 pm

1 stop12h 15m

$500

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 3/9

11:10 pm-12:30 am

1 stop22h 20m

Santiago Arturo Merino Benitez

Thu 3/19

1:35 am-12:10 pm

1 stop13h 35m

$501

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 4/26

5:50 am-10:43 pm

1 stop14h 53m

Santiago Arturo Merino Benitez

Sun 5/3

11:17 am-12:15 am

1 stop14h 58m

$504

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 3/9

7:50 pm-7:30 am

Nonstop8h 40m

Santiago Arturo Merino Benitez

Fri 3/20

5:15 am-1:50 pm

1 stop11h 35m

$516

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 3/15

5:55 am-3:17 am

1 stop18h 22m

Santiago Arturo Merino Benitez

Sun 3/22

12:28 pm-12:15 am

1 stop14h 47m

$517

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 4/11

11:20 pm-10:30 pm

1 stop21h 10m

Santiago Arturo Merino Benitez

Sat 4/18

6:10 am-11:00 pm

1 stop18h 50m

$518

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 3/11

4:50 pm-10:39 am

2 stops14h 49m

Santiago Arturo Merino Benitez

Sun 3/22

11:24 am-11:10 am

1 stop26h 46m

$524

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 6/5

5:50 am-3:00 am

1 stop19h 10m

Santiago Arturo Merino Benitez

Mon 6/22

11:17 am-1:00 am

1 stop15h 43m

$525

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Santiago from

How to get the cheapest flight ticket from Mexico City to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, May is the cheapest month to fly from Mexico City to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $539. If you don’t want to visit Santiago in May, then you should wait until November to fly from Mexico City, when ticket prices are also cheap, with an average price of $563.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Tuesday when prices can be found for as low as $651. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Friday is $865.

What is the cheapest time of day to depart on your flight to Santiago?

In the morning is the cheapest time of day to fly from Mexico City to Santiago when you can find flight prices for as low as $679. Flying to Santiago in the morning is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $688 per ticket.

What is the cheapest Mexico City Benito Juarez to Santiago Arturo Merino Benitez flight route?

Fly from Mexico City Benito Juarez to Santiago Arturo Merino Benitez for the best Mexico City Benito Juarez - Santiago Arturo Merino Benitez flight prices

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $611 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Mexico City for as low as $543 on momondo.

What cabin class options are available on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights?

There are 2 cabin classes available to choose from on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Mexico City to Santiago flights?

You could potentially save up to 3% on your flight if you consider stops on a Mexico City to Santiago flight.

How have Mexico City to Santiago flight prices changed over time?

As of January 2026, prices for Mexico City to Santiago flights are approximately 3% more expensive when compared to flights at the same time last year.

When to book flights from Mexico City to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Mexico City to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Mexico City to Santiago (MEX to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mexico City to Santiago

Best Price Found

$319

Fastest flight time

8h 00m

Direct flights

Every day

Airports in Santiago

1 airport
The best one-way flight to Santiago from Mexico City in the past 72 hours is $319. The best round-trip flight deal from Mexico City to Santiago found on momondo in the last 72 hours is $315.
The fastest flight from Mexico City to Santiago takes 8h 00m
Direct flights go from Mexico City to Santiago every day.
There is 1 airport in Santiago. From Mexico City there are direct flights to Santiago Arturo Merino Benitez (SCL).
  • How far is Mexico City Benito Juarez to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Mexico City Benito Juarez to Santiago Arturo Merino Benitez is 4104.7 mi. In terms of flight time, this usually takes a little over 8h 00m.

  • When did momondo last update prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Mexico City to Santiago?

  • What is the most popular airline from Mexico City to Santiago?

Best airlines flying from Mexico City to Santiago

Compare and see reviews for airlines that fly from Mexico City to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $275Free CancellationRating
7.6
1,557 reviews
Search Copa Airlines flights
AeromexicoPriceFrom $284Free CancellationRating
7.4
1,595 reviews
Search Aeromexico flights
AviancaPriceFrom $461Free CancellationRating
6.6
2,496 reviews
Search Avianca flights
LATAM AirlinesPriceFrom $465Free CancellationRating
7.5
1,913 reviews
Search LATAM Airlines flights
  • LATAM Airlines Flights From Mexico City to Santiago

    LATAM Airlines flies from Mexico City to Santiago around 3 times per week, with 1,912 momondo users rating the airline 7.5/10. The cheapest LATAM Airlines deal from Mexico City to Santiago in the last 72 hours was $465 (round-trip), much lower than the average airfare cost of $661 for LATAM Airlines flights on this route.

  • Aeromexico Flights From Mexico City to Santiago

    Aeromexico is also a popular choice for this route. Aeromexico flight deals for Mexico City to Santiago start from as low as $284 round-trip, depending on your selected dates, with average Aeromexico deals seen on momondo around $608. Aeromexico operates 7 flights to Santiago from Mexico City in an average week. Users have rated it 7.4/10 across 1,596 reviews.

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Mexico City to Santiago?

Finding the right flight to Santiago from Mexico City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from Mexico City to Santiago with flexible booking policies on momondo?

All flight searches from Mexico City to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Mexico City to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Mexico City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mexico City to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Mexico City to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Fri 2/20
Fri 2/27

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