Cheap flights from Mexico City to Santiago from $261

In general, May is the cheapest month to fly from Mexico City to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $531. If you don’t want to visit Santiago in May, then you should wait until November to fly from Mexico City, when ticket prices are also cheap, with an average price of $559.

The cheapest day to depart on your flight to Santiago is on a Thursday when prices can be found for as low as $643. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Friday is $865.

In the morning is the cheapest time of day to fly from Mexico City to Santiago when you can find flight prices for as low as $673. Flying to Santiago in the morning is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $684 per ticket.

Fly from Mexico City Benito Juarez to Santiago Arturo Merino Benitez for the best Mexico City Benito Juarez - Santiago Arturo Merino Benitez flight prices

You are more likely to see cheaper flights to Santiago from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $609 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Mexico City for as low as $520 on momondo.

There are 2 cabin classes available to choose from on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 3% on your flight if you consider stops on a Mexico City to Santiago flight.

As of February 2026, prices for Mexico City to Santiago flights are approximately 15% more expensive when compared to flights at the same time last year.

Copa Airlines is the most popular carrier operating from Mexico City Benito Juarez to Santiago Arturo Merino Benitez

LATAM Airlines, Aeromexico and Copa Airlines are the top three most popular airlines that fly to Santiago from Mexico City according to our data. LATAM Airlines is the first choice among our users, with 63% of people opting to fly with this airline when traveling to Santiago. Keep in mind that there are 4 different airlines that fly to Santiago on a routine basis, so you have a few additional options to choose from.

Historically, on average around 10% of flights between Mexico City and Santiago have experienced a delay on any given week. The average delay length over the past 12 months has been 122 minutes.

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights in the evening have, in the past, seen delays more frequently in comparison.

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Saturday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the least number of delays on this route over the last 12 months; with about 2% of their flights experiencing any sort of delay.

Panama City (PTY) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Flights via Bogotá (BOG) offer the lowest average round-trip price of $571.

Flights connecting via Panama City (PTY) have the shortest average one-way travel time: 11h 20m.

Panama City (PTY) has the shortest average layover time for this route: 1h 13m.

3 flights are operational daily from Mexico City to Santiago as of February 2026. The most popular departure time for this route is 10:00AM, with 82% of flights per day taking off at noon.

As of February 2026, there are 21 flights per week flying from Mexico City to Santiago. The most common day of the week flights depart is Mon, with 14% of flights taking off on this day.