Cheap flights from Mexico City to Santiago from $247

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mexico City to Santiago departing on 1/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Enter your travel dates to find the best prices.
LATAM Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
LATAM Airlines Logo
9:00 am - 2:50 pm
SCL
-
MEX
8h 50mnonstop
$515LATAM Airlines
Wed, Feb 4 - Wed, Feb 11
Copa Airlines Logo
5:55 am - 8:20 pm
MEX
-
SCL
11h 25m1 stop
Copa Airlines Logo
12:28 pm - 12:15 am
SCL
-
MEX
14h 47m1 stop
$571Copa Airlines
Sat, Jan 17 - Thu, Jan 29
LATAM Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
LATAM Airlines Logo
5:15 am - 1:50 pm
SCL
-
MEX
11h 35m1 stop
$572LATAM Airlines
Sat, Jan 17 - Thu, Jan 29
LATAM Airlines Logo
5:15 pm - 2:10 pm
MEX
-
SCL
17h 55m2 stops
LATAM Airlines Logo
9:00 am - 2:50 pm
SCL
-
MEX
8h 50mnonstop
$574LATAM Airlines
Wed, Feb 4 - Wed, Feb 11
LATAM Airlines Logo
4:00 pm - 5:35 pm
MEX
-
SCL
22h 35m1 stop
LATAM Airlines Logo
9:00 am - 2:50 pm
SCL
-
MEX
8h 50mnonstop
$575LATAM Airlines
Mon, Feb 16 - Wed, Feb 25
LATAM Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
LATAM Airlines Logo
4:35 am - 1:50 pm
SCL
-
MEX
12h 15m1 stop
$577LATAM Airlines
Thu, Jan 15 - Fri, Jan 30
LATAM Airlines Logo
4:00 pm - 5:35 pm
MEX
-
SCL
22h 35m1 stop
LATAM Airlines Logo
4:35 am - 1:50 pm
SCL
-
MEX
12h 15m1 stop
$581LATAM Airlines
Mon, Feb 16 - Tue, Feb 24
Multiple Airlines Logo
9:55 pm - 2:40 pm
MEX
-
SCL
13h 45m1 stop
Multiple Airlines Logo
11:05 pm - 11:10 am
SCL
-
MEX
15h 05m1 stop
$587Multiple Airlines
Thu, Feb 19 - Wed, Feb 25
Multiple Airlines Logo
9:55 pm - 2:40 pm
MEX
-
SCL
13h 45m1 stop
Multiple Airlines Logo
9:05 pm - 11:10 am
SCL
-
MEX
17h 05m1 stop
$597Multiple Airlines
Wed, Feb 18 - Sun, Feb 22
Multiple Airlines Logo
9:55 pm - 2:40 pm
MEX
-
SCL
13h 45m1 stop
Multiple Airlines Logo
9:05 pm - 11:10 am
SCL
-
MEX
17h 05m1 stop
$604Multiple Airlines
Wed, Feb 18 - Thu, Feb 26

LATAM Airlines flights from Mexico City to Santiago

Our best LATAM Airlines deals on Mexico City to Santiago flight tickets
LATAM Airlines
Feb 4
MEX7:50 pmMexico City Benito Juarez
8h 40m
SCL7:30 amSantiago Arturo Merino Benitez
Feb 11
SCL9:00 amSantiago Arturo Merino Benitez
8h 50m
MEX2:50 pmMexico City Benito Juarez
LATAM Airlines
Jan 17
MEX7:50 pmMexico City Benito Juarez
8h 40m
SCL7:30 amSantiago Arturo Merino Benitez
Jan 29
SCL5:15 amSantiago Arturo Merino Benitez
11h 35m
1 stop
MEX1:50 pmMexico City Benito Juarez
LATAM Airlines
Feb 4
MEX5:15 pmMexico City Benito Juarez
17h 55m
2 stops
SCL2:10 pmSantiago Arturo Merino Benitez
Feb 11
SCL9:00 amSantiago Arturo Merino Benitez
8h 50m
MEX2:50 pmMexico City Benito Juarez

Copa Airlines flights from Mexico City to Santiago

Our best Copa Airlines deals on Mexico City to Santiago flight tickets
Copa Airlines
Dec 24
MEX5:55 amMexico City Benito Juarez
11h 26m
1 stop
SCL8:21 pmSantiago Arturo Merino Benitez
Dec 31
SCL5:12 amSantiago Arturo Merino Benitez
19h 53m
1 stop
MEX10:05 pmMexico City Benito Juarez
Copa Airlines
Jan 17
MEX5:55 amMexico City Benito Juarez
11h 25m
1 stop
SCL8:20 pmSantiago Arturo Merino Benitez
Jan 29
SCL12:28 pmSantiago Arturo Merino Benitez
14h 47m
1 stop
MEX12:15 amMexico City Benito Juarez
Copa Airlines
Jan 8
MEX9:25 amMexico City Benito Juarez
11h 18m
1 stop
SCL11:43 pmSantiago Arturo Merino Benitez
Jan 18
SCL5:20 amSantiago Arturo Merino Benitez
19h 45m
1 stop
MEX10:05 pmMexico City Benito Juarez

momondo Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 2/4

7:50 pm-7:30 am

Nonstop8h 40m

Santiago Arturo Merino Benitez

Wed 2/11

9:00 am-2:50 pm

Nonstop8h 50m

$515

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 1/17

5:55 am-8:20 pm

1 stop11h 25m

Santiago Arturo Merino Benitez

Thu 1/29

12:28 pm-12:15 am

1 stop14h 47m

$571

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 1/17

7:50 pm-7:30 am

Nonstop8h 40m

Santiago Arturo Merino Benitez

Thu 1/29

5:15 am-1:50 pm

1 stop11h 35m

$572

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 2/4

5:15 pm-2:10 pm

2 stops17h 55m

Santiago Arturo Merino Benitez

Wed 2/11

9:00 am-2:50 pm

Nonstop8h 50m

$574

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 2/16

4:00 pm-5:35 pm

1 stop22h 35m

Santiago Arturo Merino Benitez

Wed 2/25

9:00 am-2:50 pm

Nonstop8h 50m

$575

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 1/15

7:50 pm-7:30 am

Nonstop8h 40m

Santiago Arturo Merino Benitez

Fri 1/30

4:35 am-1:50 pm

1 stop12h 15m

$577

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 2/16

4:00 pm-5:35 pm

1 stop22h 35m

Santiago Arturo Merino Benitez

Tue 2/24

4:35 am-1:50 pm

1 stop12h 15m

$581

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 2/19

9:55 pm-2:40 pm

1 stop13h 45m

Santiago Arturo Merino Benitez

Wed 2/25

11:05 pm-11:10 am

1 stop15h 05m

$587

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 2/18

9:55 pm-2:40 pm

1 stop13h 45m

Santiago Arturo Merino Benitez

Sun 2/22

9:05 pm-11:10 am

1 stop17h 05m

$597

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 2/18

9:55 pm-2:40 pm

1 stop13h 45m

Santiago Arturo Merino Benitez

Thu 2/26

9:05 pm-11:10 am

1 stop17h 05m

$604

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Mexico City to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Mexico City and Santiago?

What is the cheapest month to fly to Santiago?

In general, May is the cheapest month to fly from Mexico City to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $536. If you don’t want to visit Santiago in May, then you should wait until November to fly from Mexico City, when ticket prices are also cheap, with an average price of $564.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Thursday when prices can be found for as low as $673. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $724.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Mexico City to Santiago when you can find flight prices for as low as $592. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Santiago, so prices are often more expensive at around $770 per ticket.

What is the cheapest Mexico City Benito Juarez to Santiago Arturo Merino Benitez flight route?

Fly from Mexico City Benito Juarez to Santiago Arturo Merino Benitez for the best Mexico City Benito Juarez - Santiago Arturo Merino Benitez flight prices

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $616 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Mexico City for as low as $542 on momondo.

What cabin class options are available on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights?

There are 2 cabin classes available to choose from on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Mexico City to Santiago flights?

No. A direct flight is the cheapest option for a flight between Mexico City to Santiago.

How have Mexico City to Santiago flight prices changed over time?

As of December 2025, prices for Mexico City to Santiago flights are approximately 5% more expensive when compared to flights at the same time last year.

When to book flights from Mexico City to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Mexico City to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Mexico City to Santiago (MEX to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mexico City to Santiago

Best Price Found

$263

Fastest flight time

8h 00m

Direct flights

Every day

Airports in Santiago

1 airport
The best one-way flight to Santiago from Mexico City in the past 72 hours is $263. The best round-trip flight deal from Mexico City to Santiago found on momondo in the last 72 hours is $540.
The fastest flight from Mexico City to Santiago takes 8h 00m
Direct flights go from Mexico City to Santiago every day.
There is 1 airport in Santiago. From Mexico City there are direct flights to Santiago Arturo Merino Benitez (SCL).
  • How far is Mexico City Benito Juarez to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Mexico City Benito Juarez to Santiago Arturo Merino Benitez is 4104.7 mi. In terms of flight time, this usually takes a little over 8h 00m.

  • When did momondo last update prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Mexico City to Santiago?

  • What is the most popular airline from Mexico City to Santiago?

Best airlines flying from Mexico City to Santiago

Compare and see reviews for airlines that fly from Mexico City to Santiago with momondo
Airline
Rating
Free Cancellation
Price
AeromexicoPriceFrom $303Free CancellationRating
7.4
1,626 reviews
Search Aeromexico flights
Copa AirlinesPriceFrom $423Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
AviancaPriceFrom $461Free CancellationRating
6.6
2,492 reviews
Search Avianca flights
LATAM AirlinesPriceFrom $476Free CancellationRating
7.5
1,894 reviews
Search LATAM Airlines flights
  • LATAM Airlines Flights From Mexico City to Santiago

    LATAM Airlines flies from Mexico City to Santiago around 9 times per week, with 1,894 momondo users rating the airline 7.5/10. The cheapest LATAM Airlines deal from Mexico City to Santiago in the last 72 hours was $476 (round-trip), much lower than the average airfare cost of $656 for LATAM Airlines flights on this route.

  • Aeromexico Flights From Mexico City to Santiago

    Aeromexico is also a popular choice for this route. Aeromexico flight deals for Mexico City to Santiago start from as low as $303 round-trip, depending on your selected dates, with average Aeromexico deals seen on momondo around $673. Aeromexico operates 3 flights to Santiago from Mexico City in an average week. Users have rated it 7.4/10 across 1,626 reviews.

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Mexico City to Santiago?

Finding the right flight to Santiago from Mexico City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from Mexico City to Santiago with flexible booking policies on momondo?

All flight searches from Mexico City to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Mexico City to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Mexico City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mexico City to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Mexico City to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Thu 1/22
Thu 1/29

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