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Cheap flights from Mexico City to Santiago from $254

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mexico City to Santiago departing on 12/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Copa Airlines Logo
2:00 am - 12:04 amMEX-SCL
19h 04m1 stop
Copa Airlines Logo
4:47 am - 2:30 pmSCL-MEX
12h 43m1 stop
$504Copa Airlines
Find Deal
Sun, Oct 12 - Thu, Oct 16
Avianca Logo
12:40 am - 3:20 pmMEX-SCL
35h 40m1 stop
Avianca Logo
1:35 am - 12:10 pmSCL-MEX
13h 35m1 stop
$505Avianca
Find Deal
Wed, Mar 11 - Mon, Mar 16
Multiple Airlines Logo
7:05 pm - 2:25 pmMEX-SCL
16h 20m2 stops
Multiple Airlines Logo
9:50 pm - 2:55 pmSCL-MEX
20h 05m1 stop
$506Multiple Airlines
Find Deal
Tue, Oct 7 - Tue, Oct 14
LATAM Airlines Logo
7:00 pm - 3:30 pmMEX-SCL
17h 30m2 stops
LATAM Airlines Logo
10:15 pm - 1:50 pmSCL-MEX
18h 35m1 stop
$507LATAM Airlines
Find Deal
Wed, Mar 11 - Thu, Mar 19
Copa Airlines Logo
1:20 am - 11:41 pmMEX-SCL
19h 21m1 stop
Copa Airlines Logo
3:23 am - 2:30 pmSCL-MEX
14h 07m1 stop
$509Copa Airlines
Find Deal
Sun, Nov 16 - Thu, Nov 27
LATAM Airlines Logo
7:50 pm - 6:55 amMEX-SCL
8h 05mnonstop
LATAM Airlines Logo
4:35 am - 1:50 pmSCL-MEX
12h 15m1 stop
$513LATAM Airlines
Find Deal
Thu, Feb 19 - Sat, Feb 28
LATAM Airlines Logo
4:00 pm - 5:50 amMEX-SCL
10h 50m1 stop
LATAM Airlines Logo
9:15 am - 2:55 pmSCL-MEX
8h 40mnonstop
$515LATAM Airlines
Find Deal
Wed, Dec 3 - Thu, Dec 4
Multiple Airlines Logo
4:00 pm - 3:30 pmMEX-SCL
20h 30m1 stop
Multiple Airlines Logo
9:30 am - 3:00 pmSCL-MEX
32h 30m1 stop
$517Multiple Airlines
Find Deal
Sat, Feb 28 - Sun, Mar 8
LATAM Airlines Logo
8:00 pm - 7:50 amMEX-SCL
8h 50mnonstop
LATAM Airlines Logo
9:15 am - 2:55 pmSCL-MEX
8h 40mnonstop
$518LATAM Airlines
Find Deal
Tue, Oct 7 - Mon, Dec 1
Aeromexico Logo
10:00 am - 9:15 pmMEX-SCL
8h 15mnonstop
Aeromexico Logo
11:25 pm - 5:05 amSCL-MEX
8h 40mnonstop
$561Aeromexico
Find Deal
Mon, Nov 3 - Tue, Nov 11

Avianca flights from Mexico City to Santiago

Our best Avianca deals on Mexico City to Santiago flight tickets
Avianca
Mar 11
MEX12:40 amMexico City Benito Juarez
35h 40m
1 stop
SCL3:20 pmSantiago Arturo Merino Benitez
Mar 16
SCL1:35 amSantiago Arturo Merino Benitez
13h 35m
1 stop
MEX12:10 pmMexico City Benito Juarez
$505
Find similar
Avianca
Oct 8
MEX12:40 amMexico City Benito Juarez
19h 50m
1 stop
SCL11:30 pmSantiago Arturo Merino Benitez
Oct 22
SCL7:10 amSantiago Arturo Merino Benitez
18h 50m
1 stop
MEX11:00 pmMexico City Benito Juarez
$541
Find similar
Avianca
Sep 29
MEX5:00 amMexico City Benito Juarez
21h 15m
2 stops
SCL5:15 amSantiago Arturo Merino Benitez
Oct 2
SCL7:10 amSantiago Arturo Merino Benitez
18h 50m
1 stop
MEX11:00 pmMexico City Benito Juarez
$567
Find similar

Copa Airlines flights from Mexico City to Santiago

Our best Copa Airlines deals on Mexico City to Santiago flight tickets
Copa Airlines
Oct 12
MEX2:00 amMexico City Benito Juarez
19h 04m
1 stop
SCL12:04 amSantiago Arturo Merino Benitez
Oct 16
SCL4:47 amSantiago Arturo Merino Benitez
12h 43m
1 stop
MEX2:30 pmMexico City Benito Juarez
$504
Find similar
Copa Airlines
Nov 16
MEX1:20 amMexico City Benito Juarez
19h 21m
1 stop
SCL11:41 pmSantiago Arturo Merino Benitez
Nov 27
SCL3:23 amSantiago Arturo Merino Benitez
14h 07m
1 stop
MEX2:30 pmMexico City Benito Juarez
$509
Find similar
Copa Airlines
Nov 17
MEX5:55 amMexico City Benito Juarez
18h 48m
1 stop
SCL3:43 amSantiago Arturo Merino Benitez
Nov 27
SCL3:23 amSantiago Arturo Merino Benitez
18h 57m
1 stop
MEX7:20 pmMexico City Benito Juarez
$530
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 18, 2025.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 10/12

2:00 am-12:04 am

1 stop19h 04m

Santiago Arturo Merino Benitez

Thu 10/16

4:47 am-2:30 pm

1 stop12h 43m

$504

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 3/11

12:40 am-3:20 pm

1 stop35h 40m

Santiago Arturo Merino Benitez

Mon 3/16

1:35 am-12:10 pm

1 stop13h 35m

$505

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 10/7

7:05 pm-2:25 pm

2 stops16h 20m

Santiago Arturo Merino Benitez

Tue 10/14

9:50 pm-2:55 pm

1 stop20h 05m

$506

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 3/11

7:00 pm-3:30 pm

2 stops17h 30m

Santiago Arturo Merino Benitez

Thu 3/19

10:15 pm-1:50 pm

1 stop18h 35m

$507

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 11/16

1:20 am-11:41 pm

1 stop19h 21m

Santiago Arturo Merino Benitez

Thu 11/27

3:23 am-2:30 pm

1 stop14h 07m

$509

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 2/19

7:50 pm-6:55 am

Nonstop8h 05m

Santiago Arturo Merino Benitez

Sat 2/28

4:35 am-1:50 pm

1 stop12h 15m

$513

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 12/3

4:00 pm-5:50 am

1 stop10h 50m

Santiago Arturo Merino Benitez

Thu 12/4

9:15 am-2:55 pm

Nonstop8h 40m

$515

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 2/28

4:00 pm-3:30 pm

1 stop20h 30m

Santiago Arturo Merino Benitez

Sun 3/8

9:30 am-3:00 pm

1 stop32h 30m

$517

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 10/7

8:00 pm-7:50 am

Nonstop8h 50m

Santiago Arturo Merino Benitez

Mon 12/1

9:15 am-2:55 pm

Nonstop8h 40m

$518

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 11/3

10:00 am-9:15 pm

Nonstop8h 15m

Santiago Arturo Merino Benitez

Tue 11/11

11:25 pm-5:05 am

Nonstop8h 40m

$561

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Mexico City to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Mexico City and Santiago?

What is the cheapest month to fly to Santiago?

In general, May is the cheapest month to fly from Mexico City to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $536. If you don’t want to visit Santiago in May, then you should wait until August to fly from Mexico City, when ticket prices are also cheap, with an average price of $578.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Wednesday when prices can be found for as low as $744. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $875.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Mexico City to Santiago when you can find flight prices for as low as $592. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $934 per ticket.

What is the cheapest Mexico City Benito Juarez to Santiago Arturo Merino Benitez flight route?

Fly from Mexico City Benito Juarez to Santiago Arturo Merino Benitez for the best Mexico City Benito Juarez - Santiago Arturo Merino Benitez flight prices

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $626 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Mexico City for as low as $538 on momondo.

What cabin class options are available on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights?

There are 3 cabin classes available to choose from on Mexico City Benito Juarez to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Mexico City to Santiago flights?

You could potentially save up to 9% on your flight if you consider stops on a Mexico City to Santiago flight.

How have Mexico City to Santiago flight prices changed over time?

As of September 2025, prices for Mexico City to Santiago flights are approximately 17% cheaper when compared to flights at the same time last year.

When to book flights from Mexico City to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Mexico City to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Mexico City to Santiago (MEX to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mexico City to Santiago

Best Price Found

$672

Fastest flight time

8h 00m

Direct flights

Every day

Airports in Santiago

1 airport
The best one-way flight to Santiago from Mexico City in the past 72 hours is $672. The best round-trip flight deal from Mexico City to Santiago found on momondo in the last 72 hours is $622.
The fastest flight from Mexico City to Santiago takes 8h 00m
Direct flights go from Mexico City to Santiago every day.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
Search flight deals

  • How far is Mexico City Benito Juarez to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Mexico City Benito Juarez to Santiago Arturo Merino Benitez is 4104.7 mi. In terms of flight time, this usually takes a little over 8h 00m.

  • When did momondo last update prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Mexico City to Santiago?

  • What is the most popular airline from Mexico City to Santiago?

Best airlines flying from Mexico City to Santiago

Compare and see reviews for airlines that fly from Mexico City to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $314Free CancellationRating
7.5
1,531 reviews
Search Copa Airlines flights
AeromexicoPriceFrom $323Free CancellationRating
7.4
1,697 reviews
Search Aeromexico flights
AviancaPriceFrom $330Free CancellationRating
6.7
2,432 reviews
Search Avianca flights
LATAM AirlinesPriceFrom $491Free CancellationRating
7.5
1,849 reviews
Search LATAM Airlines flights

  • LATAM Airlines Flights From Mexico City to Santiago

    LATAM Airlines flies from Mexico City to Santiago around 7 times per week, with 1,849 momondo users rating the airline 7.5/10. The cheapest LATAM Airlines deal from Mexico City to Santiago in the last 72 hours was $491 (round-trip), much lower than the average airfare cost of $687 for LATAM Airlines flights on this route.

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Mexico City to Santiago?

Finding the right flight to Santiago from Mexico City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from Mexico City to Santiago with flexible booking policies on momondo?

All flight searches from Mexico City to Santiago on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Mexico City to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Mexico City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mexico City to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Mexico City to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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