Cheap flights from Mexico City to Panama City from $173

In general, January is the cheapest month to fly from Mexico City to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $364. If you’re not able to fly to Panama City in January, then February is your next best option. Flight prices from Mexico City to Panama City during February average around $365.

Our data shows that Friday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $506. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $598. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Mexico City to Panama City during this time can be as low as $516. Try not to purchase tickets at noon because they tend to be around $558. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Mexico City Benito Juarez to Panama City Tocumen Intl for the best Mexico City Benito Juarez - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $396 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Mexico City for as low as $359 on momondo.

There are 3 cabin classes available to choose from on Mexico City to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 66% on your flight if you consider stops on a Mexico City to Panama City flight.

As of August 2026, prices for Mexico City to Panama City flights are approximately 12% cheaper when compared to flights at the same time last year.

Copa Airlines is the most popular carrier operating from Mexico City Benito Juarez to Panama City Tocumen Intl

Copa Airlines, Aeromexico and Avianca are the top three most popular airlines that fly to Panama City from Mexico City according to our data. Copa Airlines is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 3 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

Historically, on average around 4% of flights between Mexico City and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 119 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Saturday is statistically the day of the week which experiences the fewest number of delays on this flight route. Wednesday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the least number of delays on this route over the last 12 months; with about 4% of their flights experiencing any sort of delay.

As of August 2026, there are 8 flights per day flying from Mexico City to Panama City. The most common time of day flights depart is 9:00AM, with 42% of flights taking off in the afternoon.

As of August 2026, 58 flights take off from Mexico City and land in Panama City each week. The most common flight departure day for this route is Tue, with 16% of weekly flights taking off on this day.