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Cheap flights from Mexico City to Panama City from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mexico City to Panama City departing on 12/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Mexico City to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
12:40 am - 2:00 pm
MEX
-
PTY
12h 20m1 stop
Avianca Logo
2:55 pm - 10:55 pm
PTY
-
MEX
9h 00m1 stop
$345Avianca
Thu, Feb 5 - Sun, Feb 22
Avianca Logo
5:00 am - 4:55 pm
MEX
-
PTY
10h 55m1 stop
Avianca Logo
5:50 pm - 3:00 am
PTY
-
MEX
10h 10m1 stop
$357Avianca
Sat, Jan 24 - Sat, Jan 31
Copa Airlines Logo
3:30 pm - 8:15 pm
MEX
-
PTY
3h 45mnonstop
Copa Airlines Logo
4:17 pm - 7:20 pm
PTY
-
MEX
4h 03mnonstop
$359Copa Airlines
Sun, Dec 28 - Wed, Feb 11
Copa Airlines Logo
3:30 pm - 8:15 pm
MEX
-
PTY
3h 45mnonstop
Copa Airlines Logo
9:21 am - 12:10 pm
PTY
-
MEX
3h 49mnonstop
$363Copa Airlines
Mon, Dec 29 - Tue, Jan 13
Avianca Logo
5:00 am - 4:55 pm
MEX
-
PTY
10h 55m1 stop
Avianca Logo
7:50 pm - 1:15 am
PTY
-
MEX
6h 25m1 stop
$364Avianca
Fri, Jan 30 - Mon, Feb 2
Avianca Logo
5:00 am - 2:00 pm
MEX
-
PTY
8h 00m1 stop
Avianca Logo
2:55 am - 12:10 pm
PTY
-
MEX
10h 15m1 stop
$373Avianca
Thu, Feb 5 - Mon, Feb 9
Copa Airlines Logo
1:10 pm - 5:48 pm
MEX
-
PTY
3h 38mnonstop
Copa Airlines Logo
11:45 am - 2:30 pm
PTY
-
MEX
3h 45mnonstop
$381Copa Airlines
Fri, Feb 6 - Sun, Feb 22
Copa Airlines Logo
1:10 pm - 5:48 pm
MEX
-
PTY
3h 38mnonstop
Copa Airlines Logo
11:45 am - 2:30 pm
PTY
-
MEX
3h 45mnonstop
$383Copa Airlines
Sun, Feb 1 - Sun, Feb 15
Copa Airlines Logo
1:20 am - 6:00 am
MEX
-
PTY
3h 40mnonstop
Copa Airlines Logo
10:14 pm - 1:00 am
PTY
-
MEX
3h 46mnonstop
$398Copa Airlines
Mon, Dec 22 - Tue, Dec 30
Copa Airlines Logo
1:10 pm - 5:48 pm
MEX
-
PTY
3h 38mnonstop
Copa Airlines Logo
11:45 am - 2:30 pm
PTY
-
MEX
3h 45mnonstop
$402Copa Airlines
Tue, Feb 17 - Sun, Feb 22

Avianca flights from Mexico City to Panama City

Our best Avianca deals on Mexico City to Panama City flight tickets
Avianca
Feb 5
MEX12:40 amMexico City Benito Juarez
12h 20m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Feb 22
PTY2:55 pmPanama City Tocumen Intl
9h 00m
1 stop
MEX10:55 pmMexico City Benito Juarez
$345
Find similar
Avianca
Jan 24
MEX5:00 amMexico City Benito Juarez
10h 55m
1 stop
PTY4:55 pmPanama City Tocumen Intl
Jan 31
PTY5:50 pmPanama City Tocumen Intl
10h 10m
1 stop
MEX3:00 amMexico City Benito Juarez
$357
Find similar
Avianca
Jan 30
MEX5:00 amMexico City Benito Juarez
10h 55m
1 stop
PTY4:55 pmPanama City Tocumen Intl
Feb 2
PTY7:50 pmPanama City Tocumen Intl
6h 25m
1 stop
MEX1:15 amMexico City Benito Juarez
$364
Find similar

Copa Airlines flights from Mexico City to Panama City

Our best Copa Airlines deals on Mexico City to Panama City flight tickets
Copa Airlines
Dec 28
MEX3:30 pmMexico City Benito Juarez
3h 45m
PTY8:15 pmPanama City Tocumen Intl
Feb 11
PTY4:17 pmPanama City Tocumen Intl
4h 03m
MEX7:20 pmMexico City Benito Juarez
$359
Find similar
Copa Airlines
Dec 29
MEX3:30 pmMexico City Benito Juarez
3h 45m
PTY8:15 pmPanama City Tocumen Intl
Jan 13
PTY9:21 amPanama City Tocumen Intl
3h 49m
MEX12:10 pmMexico City Benito Juarez
$363
Find similar
Copa Airlines
Dec 18
MEX2:00 amMexico City Benito Juarez
3h 41m
PTY6:41 amPanama City Tocumen Intl
Dec 26
PTY10:14 pmPanama City Tocumen Intl
3h 46m
MEX1:00 amMexico City Benito Juarez
$377
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 2/5

12:40 am-2:00 pm

1 stop12h 20m

Panama City Tocumen Intl

Sun 2/22

2:55 pm-10:55 pm

1 stop9h 00m

$345

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 1/24

5:00 am-4:55 pm

1 stop10h 55m

Panama City Tocumen Intl

Sat 1/31

5:50 pm-3:00 am

1 stop10h 10m

$357

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sun 12/28

3:30 pm-8:15 pm

Nonstop3h 45m

Panama City Tocumen Intl

Wed 2/11

4:17 pm-7:20 pm

Nonstop4h 03m

$359

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 12/29

3:30 pm-8:15 pm

Nonstop3h 45m

Panama City Tocumen Intl

Tue 1/13

9:21 am-12:10 pm

Nonstop3h 49m

$363

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 1/30

5:00 am-4:55 pm

1 stop10h 55m

Panama City Tocumen Intl

Mon 2/2

7:50 pm-1:15 am

1 stop6h 25m

$364

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 2/5

5:00 am-2:00 pm

1 stop8h 00m

Panama City Tocumen Intl

Mon 2/9

2:55 am-12:10 pm

1 stop10h 15m

$373

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 2/6

1:10 pm-5:48 pm

Nonstop3h 38m

Panama City Tocumen Intl

Sun 2/22

11:45 am-2:30 pm

Nonstop3h 45m

$381

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sun 2/1

1:10 pm-5:48 pm

Nonstop3h 38m

Panama City Tocumen Intl

Sun 2/15

11:45 am-2:30 pm

Nonstop3h 45m

$383

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 12/22

1:20 am-6:00 am

Nonstop3h 40m

Panama City Tocumen Intl

Tue 12/30

10:14 pm-1:00 am

Nonstop3h 46m

$398

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 2/17

1:10 pm-5:48 pm

Nonstop3h 38m

Panama City Tocumen Intl

Sun 2/22

11:45 am-2:30 pm

Nonstop3h 45m

$402

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Mexico City to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, July is the cheapest month to fly from Mexico City to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $351. If you’re not able to fly to Panama City in July, then August is your next best option. Flight prices from Mexico City to Panama City during August average around $351.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $416. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $552. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Mexico City to Panama City during this time can be as low as $433. Try not to purchase tickets at noon because they tend to be around $562. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Mexico City Benito Juarez to Panama City Tocumen Intl flight route?

Fly from Mexico City Benito Juarez to Panama City Tocumen Intl for the best Mexico City Benito Juarez - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $390 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Mexico City for as low as $353 on momondo.

What cabin class options are available on Mexico City Benito Juarez to Panama City Tocumen Intl flights?

There are 2 cabin classes available to choose from on Mexico City Benito Juarez to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Mexico City to Panama City flight prices changed over time?

As of December 2025, prices for Mexico City to Panama City flights are approximately 15% cheaper when compared to flights at the same time last year.

When to book flights from Mexico City to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Mexico City to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Mexico City to Panama City (MEX to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mexico City to Panama City

Best Price Found

$261

Fastest flight time

3h 38m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Mexico City in the past 72 hours is $261. The best round-trip flight deal from Mexico City to Panama City found on momondo in the last 72 hours is $428.
The fastest flight from Mexico City to Panama City takes 3h 38m
Direct flights go from Mexico City to Panama City every day.
There is 1 airport in Panama City. From Mexico City there are direct flights to Panama City Tocumen Intl (PTY).
Search flight deals

  • How far is Mexico City Benito Juarez to Panama City Tocumen Intl by plane?

    There are 1496.2 mi between Mexico City Benito Juarez and Panama City Tocumen Intl. Typically, this will take 3h 38m by plane in normal conditions.

  • When did momondo last update prices for flights from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Mexico City to Panama City?

  • What is the most popular airline from Mexico City to Panama City?

Best airlines flying from Mexico City to Panama City

Compare and see reviews for airlines that fly from Mexico City to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AeromexicoPriceFrom $303Free CancellationRating
7.4
1,642 reviews
Search Aeromexico flights
Copa AirlinesPriceFrom $329Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
AviancaPriceFrom $337Free CancellationRating
6.6
2,480 reviews
Search Avianca flights

  • Copa Airlines Flights From Mexico City to Panama City

    Copa Airlines flight deals from Mexico City to Panama City start from $329 round-trip. Over the 37 Copa Airlines flights for this route in a normal week, average airfare is usually $433 round-trip - but some users have found much cheaper deals with momondo.

  • Aeromexico Flights From Mexico City to Panama City

    Across 1,642 Aeromexico reviews on momondo, the average score is 7.4/10. Aeromexico flies from Mexico City to Panama City about 7 times each week, with ticket deals ranging from $303 to $363. Price data is based on momondo searches in the last 72 hours.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Mexico City to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Mexico City to Panama City for you.

Can I find flights from Mexico City to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Mexico City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Mexico City to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Mexico City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mexico City to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Mexico City to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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