Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Mexico City to Panama City from $145

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mexico City to Panama City departing on 12/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Mexico City to Panama City

Cheap round-trip flights

Avianca Logo
11:15 pm - 2:00 pmMEX-PTY
13h 45m1 stop
Avianca Logo
3:35 pm - 1:15 amPTY-MEX
10h 40m1 stop
$326Avianca
Find Deal
Fri, Oct 31 - Wed, Nov 5
Copa Airlines Logo
3:30 pm - 8:13 pmMEX-PTY
3h 43mnonstop
Copa Airlines Logo
10:21 pm - 1:00 amPTY-MEX
3h 39mnonstop
$329Copa Airlines
Find Deal
Fri, Oct 3 - Sun, Oct 12
Aeromexico Logo
8:40 am - 1:32 pmMEX-PTY
3h 52mnonstop
Aeromexico Logo
2:36 pm - 5:35 pmPTY-MEX
3h 59mnonstop
$330Aeromexico
Find Deal
Fri, Oct 31 - Tue, Nov 4
Aeromexico Logo
8:40 am - 1:32 pmMEX-PTY
3h 52mnonstop
Aeromexico Logo
2:36 pm - 5:35 pmPTY-MEX
3h 59mnonstop
$343Aeromexico
Find Deal
Wed, Nov 26 - Wed, Dec 17
Copa Airlines Logo
1:20 am - 6:00 amMEX-PTY
3h 40mnonstop
Copa Airlines Logo
7:02 pm - 10:05 pmPTY-MEX
4h 03mnonstop
$355Copa Airlines
Find Deal
Mon, Feb 2 - Thu, Feb 12
Aeromexico Logo
8:40 am - 1:32 pmMEX-PTY
3h 52mnonstop
Aeromexico Logo
3:02 pm - 5:40 pmPTY-MEX
3h 38mnonstop
$356Aeromexico
Find Deal
Fri, Dec 12 - Wed, Jan 7
Copa Airlines Logo
2:00 am - 6:44 amMEX-PTY
3h 44mnonstop
Copa Airlines Logo
10:21 pm - 1:00 amPTY-MEX
3h 39mnonstop
$358Copa Airlines
Find Deal
Thu, Oct 2 - Sun, Oct 12
Avianca Logo
12:40 am - 2:00 pmMEX-PTY
12h 20m1 stop
Avianca Logo
9:45 am - 10:55 pmPTY-MEX
14h 10m1 stop
$362Avianca
Find Deal
Wed, Oct 29 - Thu, Nov 6
Avianca Logo
12:40 am - 4:30 pmMEX-PTY
14h 50m1 stop
Avianca Logo
7:50 pm - 1:15 amPTY-MEX
6h 25m1 stop
$364Avianca
Find Deal
Wed, Oct 22 - Sun, Oct 26
Aeromexico Logo
8:40 am - 1:32 pmMEX-PTY
3h 52mnonstop
Aeromexico Logo
2:36 pm - 5:35 pmPTY-MEX
3h 59mnonstop
$369Aeromexico
Find Deal
Thu, Oct 30 - Sat, Nov 8

Avianca flights from Mexico City to Panama City

Our best Avianca deals on Mexico City to Panama City flight tickets
Avianca
Oct 31
MEX11:15 pmMexico City Benito Juarez
13h 45m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Nov 5
PTY3:35 pmPanama City Tocumen Intl
10h 40m
1 stop
MEX1:15 amMexico City Benito Juarez
$326
Find similar
Avianca
Oct 29
MEX12:40 amMexico City Benito Juarez
12h 20m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Nov 6
PTY9:45 amPanama City Tocumen Intl
14h 10m
1 stop
MEX10:55 pmMexico City Benito Juarez
$362
Find similar
Avianca
Oct 22
MEX12:40 amMexico City Benito Juarez
14h 50m
1 stop
PTY4:30 pmPanama City Tocumen Intl
Oct 26
PTY7:50 pmPanama City Tocumen Intl
6h 25m
1 stop
MEX1:15 amMexico City Benito Juarez
$364
Find similar

Aeromexico flights from Mexico City to Panama City

Our best Aeromexico deals on Mexico City to Panama City flight tickets
Aeromexico
Oct 31
MEX8:40 amMexico City Benito Juarez
3h 52m
PTY1:32 pmPanama City Tocumen Intl
Nov 4
PTY2:36 pmPanama City Tocumen Intl
3h 59m
MEX5:35 pmMexico City Benito Juarez
$330
Find similar
Aeromexico
Nov 26
MEX8:40 amMexico City Benito Juarez
3h 52m
PTY1:32 pmPanama City Tocumen Intl
Dec 17
PTY2:36 pmPanama City Tocumen Intl
3h 59m
MEX5:35 pmMexico City Benito Juarez
$343
Find similar
Aeromexico
Dec 12
MEX8:40 amMexico City Benito Juarez
3h 52m
PTY1:32 pmPanama City Tocumen Intl
Jan 7
PTY3:02 pmPanama City Tocumen Intl
3h 38m
MEX5:40 pmMexico City Benito Juarez
$356
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 10/31

11:15 pm-2:00 pm

1 stop13h 45m

Panama City Tocumen Intl

Wed 11/5

3:35 pm-1:15 am

1 stop10h 40m

$326

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 10/3

3:30 pm-8:13 pm

Nonstop3h 43m

Panama City Tocumen Intl

Sun 10/12

10:21 pm-1:00 am

Nonstop3h 39m

$329

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 10/31

8:40 am-1:32 pm

Nonstop3h 52m

Panama City Tocumen Intl

Tue 11/4

2:36 pm-5:35 pm

Nonstop3h 59m

$330

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 11/26

8:40 am-1:32 pm

Nonstop3h 52m

Panama City Tocumen Intl

Wed 12/17

2:36 pm-5:35 pm

Nonstop3h 59m

$343

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 2/2

1:20 am-6:00 am

Nonstop3h 40m

Panama City Tocumen Intl

Thu 2/12

7:02 pm-10:05 pm

Nonstop4h 03m

$355

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 12/12

8:40 am-1:32 pm

Nonstop3h 52m

Panama City Tocumen Intl

Wed 1/7

3:02 pm-5:40 pm

Nonstop3h 38m

$356

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 10/2

2:00 am-6:44 am

Nonstop3h 44m

Panama City Tocumen Intl

Sun 10/12

10:21 pm-1:00 am

Nonstop3h 39m

$358

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 10/29

12:40 am-2:00 pm

1 stop12h 20m

Panama City Tocumen Intl

Thu 11/6

9:45 am-10:55 pm

1 stop14h 10m

$362

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 10/22

12:40 am-4:30 pm

1 stop14h 50m

Panama City Tocumen Intl

Sun 10/26

7:50 pm-1:15 am

1 stop6h 25m

$364

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 10/30

8:40 am-1:32 pm

Nonstop3h 52m

Panama City Tocumen Intl

Sat 11/8

2:36 pm-5:35 pm

Nonstop3h 59m

$369

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Panama City from

How to get the cheapest flight ticket from Mexico City to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, July is the cheapest month to fly from Mexico City to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $351. If you’re not able to fly to Panama City in July, then August is your next best option. Flight prices from Mexico City to Panama City during August average around $351.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $421. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $571. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Mexico City to Panama City during this time can be as low as $459. Try not to purchase tickets in the afternoon because they tend to be around $550. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Mexico City Benito Juarez to Panama City Tocumen Intl flight route?

Fly from Mexico City Benito Juarez to Panama City Tocumen Intl for the best Mexico City Benito Juarez - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $416 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Mexico City for as low as $370 on momondo.

What cabin class options are available on Mexico City Benito Juarez to Panama City Tocumen Intl flights?

There are 2 cabin classes available to choose from on Mexico City Benito Juarez to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Mexico City to Panama City flight prices changed over time?

As of September 2025, prices for Mexico City to Panama City flights are approximately 9% cheaper when compared to flights at the same time last year.

When to book flights from Mexico City to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Mexico City to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Mexico City to Panama City (MEX to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mexico City to Panama City

Best Price Found

$240

Fastest flight time

3h 39m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Mexico City in the past 72 hours is $240. The best round-trip flight deal from Mexico City to Panama City found on momondo in the last 72 hours is $330.
The fastest flight from Mexico City to Panama City takes 3h 39m
Direct flights go from Mexico City to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is Mexico City Benito Juarez to Panama City Tocumen Intl by plane?

    There are 1496.2 mi between Mexico City Benito Juarez and Panama City Tocumen Intl. Typically, this will take 3h 39m by plane in normal conditions.

  • When did momondo last update prices for flights from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Mexico City to Panama City?

  • What is the most popular airline from Mexico City to Panama City?

Best airlines flying from Mexico City to Panama City

Compare and see reviews for airlines that fly from Mexico City to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AeromexicoPriceFrom $303Free CancellationRating
7.4
1,696 reviews
Search Aeromexico flights
AviancaPriceFrom $343Free CancellationRating
6.7
2,436 reviews
Search Avianca flights
Copa AirlinesPriceFrom $354Free CancellationRating
7.6
1,533 reviews
Search Copa Airlines flights

  • Copa Airlines Flights From Mexico City to Panama City

    Copa Airlines flight deals from Mexico City to Panama City start from $354 round-trip. Over the 38 Copa Airlines flights for this route in a normal week, average airfare is usually $441 round-trip - but some users have found much cheaper deals with momondo.

  • Aeromexico Flights From Mexico City to Panama City

    Across 1,696 Aeromexico reviews on momondo, the average score is 7.4/10. Aeromexico flies from Mexico City to Panama City about 3 times each week, with ticket deals ranging from $303 to $329. Price data is based on momondo searches in the last 72 hours.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Mexico City to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Mexico City to Panama City for you.

Can I find flights from Mexico City to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Mexico City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Mexico City to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Mexico City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mexico City to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Mexico City to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

An easier way to manage your Panama City trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Fri 10/17
Fri 10/24
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Panama