Cheap flights from Mexico City to Panama City from $160

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Mexico City to Panama City departing on 2/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Mexico City to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
12:40 am - 2:00 pm
MEX
-
PTY
12h 20m
1 stop
Avianca Logo
5:50 pm - 3:00 am
PTY
-
MEX
10h 10m
1 stop
$319Avianca
Fri, Feb 27 - Sat, Mar 7
Avianca Logo
12:40 am - 5:00 pm
MEX
-
PTY
15h 20m
1 stop
Avianca Logo
5:55 pm - 3:05 am
PTY
-
MEX
10h 10m
1 stop
$326Avianca
Mon, Apr 20 - Fri, Apr 24
Avianca Logo
5:00 am - 4:55 pm
MEX
-
PTY
10h 55m
1 stop
Avianca Logo
2:55 pm - 10:55 pm
PTY
-
MEX
9h 00m
1 stop
$349Avianca
Tue, Mar 3 - Tue, Mar 10
Avianca Logo
4:55 am - 2:15 pm
MEX
-
PTY
8h 20m
1 stop
Avianca Logo
5:30 am - 10:55 am
PTY
-
MEX
6h 25m
1 stop
$351Avianca
Fri, Apr 10 - Mon, Apr 20
Copa Airlines Logo
3:30 pm - 8:13 pm
MEX
-
PTY
3h 43mnonstop
Copa Airlines Logo
11:41 am - 2:30 pm
PTY
-
MEX
3h 49mnonstop
$356Copa Airlines
Wed, Mar 4 - Wed, Mar 11
Copa Airlines Logo
2:00 am - 6:40 am
MEX
-
PTY
3h 40mnonstop
Copa Airlines Logo
9:22 am - 12:10 pm
PTY
-
MEX
3h 48mnonstop
$357Copa Airlines
Sat, Feb 28 - Sat, Mar 21
Copa Airlines Logo
9:50 am - 2:30 pm
MEX
-
PTY
3h 40mnonstop
Copa Airlines Logo
11:44 am - 2:30 pm
PTY
-
MEX
3h 46mnonstop
$358Copa Airlines
Wed, Apr 15 - Wed, Apr 22
Copa Airlines Logo
3:30 pm - 8:10 pm
MEX
-
PTY
3h 40mnonstop
Copa Airlines Logo
9:19 am - 12:10 pm
PTY
-
MEX
3h 51mnonstop
$359Copa Airlines
Fri, Apr 10 - Mon, Apr 20
Copa Airlines Logo
1:10 pm - 5:48 pm
MEX
-
PTY
3h 38mnonstop
Copa Airlines Logo
11:41 am - 2:30 pm
PTY
-
MEX
3h 49mnonstop
$364Copa Airlines
Wed, Feb 25 - Wed, Mar 4
Copa Airlines Logo
9:50 am - 2:30 pm
MEX
-
PTY
3h 40mnonstop
Copa Airlines Logo
10:11 pm - 1:00 am
PTY
-
MEX
3h 49mnonstop
$366Copa Airlines
Wed, Apr 15 - Sat, Apr 25

Avianca flights from Mexico City to Panama City

Our best Avianca deals on Mexico City to Panama City flight tickets
Avianca
Feb 27
MEX12:40 amMexico City Benito Juarez
12h 20m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Mar 7
PTY5:50 pmPanama City Tocumen Intl
10h 10m
1 stop
MEX3:00 amMexico City Benito Juarez
$319
Avianca
Feb 11
MEX4:00 amMexico City Benito Juarez
5h 30m
1 stop
PTY10:30 amPanama City Tocumen Intl
Feb 19
PTY2:55 pmPanama City Tocumen Intl
9h 00m
1 stop
MEX10:55 pmMexico City Benito Juarez
$320
Avianca
Apr 20
MEX12:40 amMexico City Benito Juarez
15h 20m
1 stop
PTY5:00 pmPanama City Tocumen Intl
Apr 24
PTY5:55 pmPanama City Tocumen Intl
10h 10m
1 stop
MEX3:05 amMexico City Benito Juarez
$326

Aeromexico flights from Mexico City to Panama City

Our best Aeromexico deals on Mexico City to Panama City flight tickets
Aeromexico
Apr 8
MEX9:00 amMexico City Benito Juarez
4h 00m
PTY2:00 pmPanama City Tocumen Intl
Apr 22
PTY3:00 pmPanama City Tocumen Intl
4h 00m
MEX6:00 pmMexico City Benito Juarez
$367
Aeromexico
Mar 6
MEX8:55 amMexico City Benito Juarez
3h 51m
PTY1:46 pmPanama City Tocumen Intl
Mar 20
PTY2:48 pmPanama City Tocumen Intl
3h 57m
MEX5:45 pmMexico City Benito Juarez
$393
Aeromexico
Feb 12
MEX8:55 amMexico City Benito Juarez
3h 51m
PTY1:46 pmPanama City Tocumen Intl
Feb 19
PTY2:51 pmPanama City Tocumen Intl
3h 54m
MEX5:45 pmMexico City Benito Juarez
$413

momondo Fare Finder

 
Customize your flight search to find flights from Mexico City to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Mexico City to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 2/27

12:40 am-2:00 pm

1 stop12h 20m

Panama City Tocumen Intl

Sat 3/7

5:50 pm-3:00 am

1 stop10h 10m

$319

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Mon 4/20

12:40 am-5:00 pm

1 stop15h 20m

Panama City Tocumen Intl

Fri 4/24

5:55 pm-3:05 am

1 stop10h 10m

$326

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 3/3

5:00 am-4:55 pm

1 stop10h 55m

Panama City Tocumen Intl

Tue 3/10

2:55 pm-10:55 pm

1 stop9h 00m

$349

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 4/10

4:55 am-2:15 pm

1 stop8h 20m

Panama City Tocumen Intl

Mon 4/20

5:30 am-10:55 am

1 stop6h 25m

$351

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 3/4

3:30 pm-8:13 pm

Nonstop3h 43m

Panama City Tocumen Intl

Wed 3/11

11:41 am-2:30 pm

Nonstop3h 49m

$356

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 2/28

2:00 am-6:40 am

Nonstop3h 40m

Panama City Tocumen Intl

Sat 3/21

9:22 am-12:10 pm

Nonstop3h 48m

$357

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 4/15

9:50 am-2:30 pm

Nonstop3h 40m

Panama City Tocumen Intl

Wed 4/22

11:44 am-2:30 pm

Nonstop3h 46m

$358

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Fri 4/10

3:30 pm-8:10 pm

Nonstop3h 40m

Panama City Tocumen Intl

Mon 4/20

9:19 am-12:10 pm

Nonstop3h 51m

$359

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 2/25

1:10 pm-5:48 pm

Nonstop3h 38m

Panama City Tocumen Intl

Wed 3/4

11:41 am-2:30 pm

Nonstop3h 49m

$364

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 4/15

9:50 am-2:30 pm

Nonstop3h 40m

Panama City Tocumen Intl

Sat 4/25

10:11 pm-1:00 am

Nonstop3h 49m

$366

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Mexico City to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Mexico City and Panama City?

What is the cheapest month to fly to Panama City?

In general, July is the cheapest month to fly from Mexico City to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $351. If you’re not able to fly to Panama City in July, then August is your next best option. Flight prices from Mexico City to Panama City during August average around $351.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $429. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $549. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Mexico City to Panama City during this time can be as low as $434. Try not to purchase tickets at noon because they tend to be around $571. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Mexico City Benito Juarez to Panama City Tocumen Intl flight route?

Fly from Mexico City Benito Juarez to Panama City Tocumen Intl for the best Mexico City Benito Juarez - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Mexico City when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $382 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Mexico City for as low as $343 on momondo.

What cabin class options are available on Mexico City Benito Juarez to Panama City Tocumen Intl flights?

There are 2 cabin classes available to choose from on Mexico City Benito Juarez to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Mexico City to Panama City flights?

You could potentially save up to 8% on your flight if you consider stops on a Mexico City to Panama City flight.

How have Mexico City to Panama City flight prices changed over time?

As of February 2026, prices for Mexico City to Panama City flights are approximately 22% more expensive when compared to flights at the same time last year.

When to book flights from Mexico City to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Mexico City to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Mexico City to Panama City (MEX to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Mexico City to Panama City

Best Price Found

$243

Fastest flight time

3h 37m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Mexico City in the past 72 hours is $243. The best round-trip flight deal from Mexico City to Panama City found on momondo in the last 72 hours is $347.
The fastest flight from Mexico City to Panama City takes 3h 37m
Direct flights go from Mexico City to Panama City every day.
There is 1 airport in Panama City. From Mexico City there are direct flights to Panama City Tocumen Intl (PTY).
  • How far is Mexico City Benito Juarez to Panama City Tocumen Intl by plane?

    There are 1496.2 mi between Mexico City Benito Juarez and Panama City Tocumen Intl. Typically, this will take 3h 37m by plane in normal conditions.

  • When did momondo last update prices for flights from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Mexico City Benito Juarez Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents you'll need for your trip to Panama City Tocumen Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City Tocumen Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Mexico City to Panama City?

  • What is the most popular airline from Mexico City to Panama City?

Best airlines flying from Mexico City to Panama City

Compare and see reviews for airlines that fly from Mexico City to Panama City with momondo
Airline
Rating
Free Cancellation
Price
AeromexicoPriceFrom $225Free CancellationRating
7.4
1,583 reviews
Search Aeromexico flights
Copa AirlinesPriceFrom $328Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
AviancaPriceFrom $337Free CancellationRating
6.5
2,498 reviews
Search Avianca flights
  • Copa Airlines Flights From Mexico City to Panama City

    Copa Airlines flight deals from Mexico City to Panama City start from $328 round-trip. Over the 35 Copa Airlines flights for this route in a normal week, average airfare is usually $419 round-trip - but some users have found much cheaper deals with momondo.

  • Aeromexico Flights From Mexico City to Panama City

    Across 1,582 Aeromexico reviews on momondo, the average score is 7.4/10. Aeromexico flies from Mexico City to Panama City about 5 times each week, with ticket deals ranging from $225 to $363. Price data is based on momondo searches in the last 72 hours.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Mexico City to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Mexico City to Panama City for you.

Can I find flights from Mexico City to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Mexico City which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Mexico City to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Mexico City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Mexico City to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Mexico City to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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1 adult
Thu 3/5
Thu 3/12

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