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Cheap flights from Medellín Jose Maria Cordova Intl Airport to Santiago from $201

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Medellín Jose Maria Cordova Intl Airport to Santiago departing on 12/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Medellín Jose Maria Cordova Intl Airport to Santiago

Cheap round-trip flights

JetSMART Logo
5:00 pm - 1:08 amMDE-SCL
6h 08mnonstop
JetSMART Logo
1:58 am - 6:13 amSCL-MDE
6h 15mnonstop
$345JetSMART
Find Deal
Tue, Mar 10 - Mon, Mar 23
JetSMART Logo
10:30 am - 1:21 amMDE-SCL
12h 51m1 stop
JetSMART Logo
4:26 pm - 5:42 amSCL-MDE
15h 16m1 stop
$351JetSMART
Find Deal
Fri, Dec 12 - Thu, Feb 19
Multiple Airlines Logo
10:30 am - 1:21 amMDE-SCL
12h 51m1 stop
Multiple Airlines Logo
4:11 pm - 11:24 pmSCL-MDE
9h 13m1 stop
$371Multiple Airlines
Find Deal
Fri, Dec 12 - Sat, Feb 21
Multiple Airlines Logo
6:09 pm - 5:06 amMDE-SCL
8h 57m1 stop
Multiple Airlines Logo
6:40 am - 6:00 pmSCL-MDE
13h 20m2 stops
$380Multiple Airlines
Find Deal
Sat, Oct 25 - Sat, Nov 1
LATAM Airlines Logo
3:55 am - 10:50 pmMDE-SCL
16h 55m1 stop
LATAM Airlines Logo
6:35 am - 3:45 pmSCL-MDE
11h 10m1 stop
$392LATAM Airlines
Find Deal
Fri, Oct 17 - Thu, Oct 23
LATAM Airlines Logo
4:05 am - 7:50 pmMDE-SCL
13h 45m2 stops
LATAM Airlines Logo
1:40 pm - 3:05 amSCL-MDE
15h 25m1 stop
$394LATAM Airlines
Find Deal
Sat, Dec 6 - Sun, Feb 22
Copa Airlines Logo
6:24 am - 12:06 amMDE-SCL
15h 42m1 stop
Copa Airlines Logo
3:23 am - 2:45 pmSCL-MDE
13h 22m1 stop
$395Copa Airlines
Find Deal
Fri, Nov 14 - Mon, Nov 17
Avianca Logo
1:04 pm - 11:30 pmMDE-SCL
8h 26m1 stop
Avianca Logo
1:35 am - 9:05 amSCL-MDE
9h 30m1 stop
$402Avianca
Find Deal
Thu, Oct 2 - Tue, Nov 4
Copa Airlines Logo
8:37 am - 12:06 amMDE-SCL
13h 29m1 stop
Copa Airlines Logo
3:23 am - 2:15 pmSCL-MDE
12h 52m1 stop
$411Copa Airlines
Find Deal
Tue, Nov 4 - Thu, Nov 20
Avianca Logo
4:08 pm - 5:30 amMDE-SCL
11h 22m1 stop
Avianca Logo
1:35 am - 9:05 amSCL-MDE
9h 30m1 stop
$420Avianca
Find Deal
Sat, Oct 25 - Fri, Oct 31

Copa Airlines flights from Medellín Jose Maria Cordova Intl Airport to Santiago

Our best Copa Airlines deals on Medellín Jose Maria Cordova Intl Airport to Santiago flight tickets
Copa Airlines
Nov 14
MDE6:24 amMedellín Jose Maria Cordova Intl
15h 42m
1 stop
SCL12:06 amSantiago Arturo Merino Benitez
Nov 17
SCL3:23 amSantiago Arturo Merino Benitez
13h 22m
1 stop
MDE2:45 pmMedellín Jose Maria Cordova Intl
$395
Find similar
Copa Airlines
Nov 4
MDE8:37 amMedellín Jose Maria Cordova Intl
13h 29m
1 stop
SCL12:06 amSantiago Arturo Merino Benitez
Nov 20
SCL3:23 amSantiago Arturo Merino Benitez
12h 52m
1 stop
MDE2:15 pmMedellín Jose Maria Cordova Intl
$411
Find similar
Copa Airlines
Oct 16
MDE12:45 pmMedellín Jose Maria Cordova Intl
9h 19m
1 stop
SCL12:04 amSantiago Arturo Merino Benitez
Oct 23
SCL4:47 amSantiago Arturo Merino Benitez
10h 38m
1 stop
MDE1:25 pmMedellín Jose Maria Cordova Intl
$421
Find similar

JetSMART flights from Medellín Jose Maria Cordova Intl Airport to Santiago

Our best JetSMART deals on Medellín Jose Maria Cordova Intl Airport to Santiago flight tickets
JetSMART
Mar 10
MDE5:00 pmMedellín Jose Maria Cordova Intl
6h 08m
SCL1:08 amSantiago Arturo Merino Benitez
Mar 23
SCL1:58 amSantiago Arturo Merino Benitez
6h 15m
MDE6:13 amMedellín Jose Maria Cordova Intl
$345
Find similar
JetSMART
Dec 12
MDE10:30 amMedellín Jose Maria Cordova Intl
12h 51m
1 stop
SCL1:21 amSantiago Arturo Merino Benitez
Feb 19
SCL4:26 pmSantiago Arturo Merino Benitez
15h 16m
1 stop
MDE5:42 amMedellín Jose Maria Cordova Intl
$351
Find similar
JetSMART
Oct 25
MDE6:09 pmMedellín Jose Maria Cordova Intl
8h 57m
1 stop
SCL5:06 amSantiago Arturo Merino Benitez
Nov 1
SCL5:59 amSantiago Arturo Merino Benitez
12h 50m
1 stop
MDE4:49 pmMedellín Jose Maria Cordova Intl
$354
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Medellín Jose Maria Cordova Intl Airport to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Medellín Jose Maria Cordova Intl Airport to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Tue 3/10

5:00 pm-1:08 am

Nonstop6h 08m

Santiago Arturo Merino Benitez

Mon 3/23

1:58 am-6:13 am

Nonstop6h 15m

$345

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Fri 12/12

10:30 am-1:21 am

1 stop12h 51m

Santiago Arturo Merino Benitez

Thu 2/19

4:26 pm-5:42 am

1 stop15h 16m

$351

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Fri 12/12

10:30 am-1:21 am

1 stop12h 51m

Santiago Arturo Merino Benitez

Sat 2/21

4:11 pm-11:24 pm

1 stop9h 13m

$371

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Sat 10/25

6:09 pm-5:06 am

1 stop8h 57m

Santiago Arturo Merino Benitez

Sat 11/1

6:40 am-6:00 pm

2 stops13h 20m

$380

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Fri 10/17

3:55 am-10:50 pm

1 stop16h 55m

Santiago Arturo Merino Benitez

Thu 10/23

6:35 am-3:45 pm

1 stop11h 10m

$392

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Sat 12/6

4:05 am-7:50 pm

2 stops13h 45m

Santiago Arturo Merino Benitez

Sun 2/22

1:40 pm-3:05 am

1 stop15h 25m

$394

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Fri 11/14

6:24 am-12:06 am

1 stop15h 42m

Santiago Arturo Merino Benitez

Mon 11/17

3:23 am-2:45 pm

1 stop13h 22m

$395

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Thu 10/2

1:04 pm-11:30 pm

1 stop8h 26m

Santiago Arturo Merino Benitez

Tue 11/4

1:35 am-9:05 am

1 stop9h 30m

$402

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Tue 11/4

8:37 am-12:06 am

1 stop13h 29m

Santiago Arturo Merino Benitez

Thu 11/20

3:23 am-2:15 pm

1 stop12h 52m

$411

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Sat 10/25

4:08 pm-5:30 am

1 stop11h 22m

Santiago Arturo Merino Benitez

Fri 10/31

1:35 am-9:05 am

1 stop9h 30m

$420

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Medellín Jose Maria Cordova Intl Airport to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Medellín Jose Maria Cordova Intl Airport and Santiago?

What is the cheapest month to fly to Santiago?

In general, December is the cheapest month to fly from Medellín Jose Maria Cordova Intl Airport to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $361. If you don’t want to visit Santiago in December, then you should wait until October to fly from Medellín Jose Maria Cordova Intl Airport, when ticket prices are also cheap, with an average price of $365.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Tuesday when prices can be found for as low as $297. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $516.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Medellín Jose Maria Cordova Intl Airport to Santiago when you can find flight prices for as low as $406. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $518 per ticket.

What is the cheapest Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez flight route?

Fly from Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez for the best Medellín Jose Maria Cordova Intl - Santiago Arturo Merino Benitez flight prices

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Medellín Jose Maria Cordova Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $381 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Medellín Jose Maria Cordova Intl Airport for as low as $329 on momondo.

What cabin class options are available on Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez flights?

There is only 1 cabin class available to choose from on Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Medellín Jose Maria Cordova Intl Airport to Santiago flights?

You could potentially save up to 5% on your flight if you consider stops on a Medellín Jose Maria Cordova Intl Airport to Santiago flight.

How have Medellín Jose Maria Cordova Intl Airport to Santiago flight prices changed over time?

As of September 2025, prices for Medellín Jose Maria Cordova Intl Airport to Santiago flights are approximately 17% cheaper when compared to flights at the same time last year.

When to book flights from Medellín Jose Maria Cordova Intl Airport to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Medellín Jose Maria Cordova Intl Airport to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Medellín Jose Maria Cordova Intl Airport to Santiago (MDE to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Medellín Jose Maria Cordova Intl Airport to Santiago

Best Price Found

$353

Fastest flight time

6h 08m

Direct flights

Mon, Tue, Wed, Thu, Fri and Sat

Airports in Santiago

1 airport
The best flight deal from Medellín Jose Maria Cordova Intl Airport to Santiago found on momondo in the last 72 hours is $353
The fastest flight from Medellín Jose Maria Cordova Intl Airport to Santiago takes 6h 08m
Direct flights go from Medellín Jose Maria Cordova Intl Airport to Santiago on Monday, Tuesday, Wednesday, Thursday, Friday and Saturday. There are no airlines offering direct flights.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
Search flight deals

  • How far is Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez by plane?

    Medellín Jose Maria Cordova Intl and Santiago Arturo Merino Benitez are 2752.8 mi apart from one another. Typically, this will take 6h 08m by plane in normal conditions.

  • When did momondo last update prices for flights from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Medellín Jose Maria Cordova Intl Airport to Santiago?

  • What is the most popular airline from Medellín Jose Maria Cordova Intl Airport to Santiago?

Best airlines flying from Medellín Jose Maria Cordova Intl Airport to Santiago

Compare and see reviews for airlines that fly from Medellín Jose Maria Cordova Intl Airport to Santiago with momondo
Airline
Rating
Free Cancellation
Price
JetSMARTPriceFrom $177Free CancellationRating
6.5
225 reviews
Search JetSMART flights
LATAM AirlinesPriceFrom $256Free CancellationRating
7.5
1,847 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $336Free CancellationRating
7.6
1,531 reviews
Search Copa Airlines flights
AviancaPriceFrom $354Free CancellationRating
6.7
2,435 reviews
Search Avianca flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

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Yes. momondo allows you to filter the results for Medellín to Santiago flights to just show those with flexible booking policies.

How can momondo help me find flights from Medellín to Santiago?

Once all potential Medellín to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

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Of course. momondo tracks the price of Medellín to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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