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Cheap flights from Medellín Jose Maria Cordova Intl Airport to Santiago from $205

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Medellín Jose Maria Cordova Intl Airport to Santiago departing on 4/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Medellín Jose Maria Cordova Intl Airport to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetSMART Logo
5:01 pm - 12:09 am
MDE
-
SCL
6h 08mnonstop
JetSMART Logo
12:59 am - 6:23 am
SCL
-
MDE
6h 24mnonstop
$311JetSMART
Mon, May 4 - Thu, May 21
JetSMART Logo
5:01 pm - 12:09 am
MDE
-
SCL
6h 08mnonstop
JetSMART Logo
12:59 am - 6:23 am
SCL
-
MDE
6h 24mnonstop
$313JetSMART
Mon, Jun 1 - Sun, Jun 7
JetSMART Logo
5:01 pm - 12:09 am
MDE
-
SCL
6h 08mnonstop
JetSMART Logo
12:59 am - 6:23 am
SCL
-
MDE
6h 24mnonstop
$321JetSMART
Fri, May 1 - Sun, May 17
JetSMART Logo
5:01 pm - 12:09 am
MDE
-
SCL
6h 08mnonstop
JetSMART Logo
12:59 am - 6:23 am
SCL
-
MDE
6h 24mnonstop
$323JetSMART
Thu, May 14 - Sun, May 24
JetSMART Logo
5:30 am - 4:17 am
MDE
-
SCL
21h 47m1 stop
JetSMART Logo
12:59 am - 6:23 am
SCL
-
MDE
6h 24mnonstop
$326JetSMART
Mon, May 25 - Fri, Jun 19
JetSMART Logo
5:01 pm - 12:09 am
MDE
-
SCL
6h 08mnonstop
JetSMART Logo
12:59 am - 6:23 am
SCL
-
MDE
6h 24mnonstop
$328JetSMART
Thu, May 21 - Sun, May 24
JetSMART Logo
5:01 pm - 12:09 am
MDE
-
SCL
6h 08mnonstop
JetSMART Logo
3:33 pm - 11:00 pm
SCL
-
MDE
8h 27m1 stop
$332JetSMART
Mon, May 4 - Fri, May 22
JetSMART Logo
5:01 pm - 12:09 am
MDE
-
SCL
6h 08mnonstop
JetSMART Logo
12:59 am - 6:23 am
SCL
-
MDE
6h 24mnonstop
$333JetSMART
Fri, Apr 24 - Fri, May 1
JetSMART Logo
5:01 pm - 12:09 am
MDE
-
SCL
6h 08mnonstop
JetSMART Logo
3:33 pm - 2:07 pm
SCL
-
MDE
23h 34m1 stop
$339JetSMART
Thu, May 21 - Mon, May 25
JetSMART Logo
5:01 pm - 12:09 am
MDE
-
SCL
6h 08mnonstop
JetSMART Logo
3:33 pm - 2:54 pm
SCL
-
MDE
24h 21m1 stop
$340JetSMART
Thu, May 21 - Mon, May 25

JetSMART flights from Medellín Jose Maria Cordova Intl Airport to Santiago

Our best JetSMART deals on Medellín Jose Maria Cordova Intl Airport to Santiago flight tickets
JetSMART
May 4
MDE5:01 pmMedellín Jose Maria Cordova Intl
6h 08m
SCL12:09 amSantiago Arturo Merino Benitez
May 21
SCL12:59 amSantiago Arturo Merino Benitez
6h 24m
MDE6:23 amMedellín Jose Maria Cordova Intl
$311
Find similar
JetSMART
May 17
MDE5:01 pmMedellín Jose Maria Cordova Intl
6h 08m
SCL12:09 amSantiago Arturo Merino Benitez
May 21
SCL12:59 amSantiago Arturo Merino Benitez
6h 24m
MDE6:23 amMedellín Jose Maria Cordova Intl
$312
Find similar
JetSMART
Jun 1
MDE5:01 pmMedellín Jose Maria Cordova Intl
6h 08m
SCL12:09 amSantiago Arturo Merino Benitez
Jun 7
SCL12:59 amSantiago Arturo Merino Benitez
6h 24m
MDE6:23 amMedellín Jose Maria Cordova Intl
$313
Find similar

LATAM Airlines flights from Medellín Jose Maria Cordova Intl Airport to Santiago

Our best LATAM Airlines deals on Medellín Jose Maria Cordova Intl Airport to Santiago flight tickets
LATAM Airlines
Dec 31
MDE6:15 pmMedellín Jose Maria Cordova Intl
10h 10m
1 stop
SCL6:25 amSantiago Arturo Merino Benitez
Jan 28
SCL5:15 amSantiago Arturo Merino Benitez
13h 00m
1 stop
MDE4:15 pmMedellín Jose Maria Cordova Intl
$382
Find similar
LATAM Airlines
Dec 31
MDE6:15 pmMedellín Jose Maria Cordova Intl
10h 10m
1 stop
SCL6:25 amSantiago Arturo Merino Benitez
Jan 28
SCL5:15 amSantiago Arturo Merino Benitez
20h 15m
2 stops
MDE11:30 pmMedellín Jose Maria Cordova Intl
$384
Find similar
LATAM Airlines
Dec 31
MDE12:30 pmMedellín Jose Maria Cordova Intl
15h 55m
2 stops
SCL6:25 amSantiago Arturo Merino Benitez
Jan 28
SCL5:15 amSantiago Arturo Merino Benitez
11h 25m
2 stops
MDE2:40 pmMedellín Jose Maria Cordova Intl
$437
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Medellín Jose Maria Cordova Intl Airport to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Medellín Jose Maria Cordova Intl Airport to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Mon 5/4

5:01 pm-12:09 am

Nonstop6h 08m

Santiago Arturo Merino Benitez

Thu 5/21

12:59 am-6:23 am

Nonstop6h 24m

$311

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Mon 6/1

5:01 pm-12:09 am

Nonstop6h 08m

Santiago Arturo Merino Benitez

Sun 6/7

12:59 am-6:23 am

Nonstop6h 24m

$313

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Fri 5/1

5:01 pm-12:09 am

Nonstop6h 08m

Santiago Arturo Merino Benitez

Sun 5/17

12:59 am-6:23 am

Nonstop6h 24m

$321

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Thu 5/14

5:01 pm-12:09 am

Nonstop6h 08m

Santiago Arturo Merino Benitez

Sun 5/24

12:59 am-6:23 am

Nonstop6h 24m

$323

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Mon 5/25

5:30 am-4:17 am

1 stop21h 47m

Santiago Arturo Merino Benitez

Fri 6/19

12:59 am-6:23 am

Nonstop6h 24m

$326

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Thu 5/21

5:01 pm-12:09 am

Nonstop6h 08m

Santiago Arturo Merino Benitez

Sun 5/24

12:59 am-6:23 am

Nonstop6h 24m

$328

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Mon 5/4

5:01 pm-12:09 am

Nonstop6h 08m

Santiago Arturo Merino Benitez

Fri 5/22

3:33 pm-11:00 pm

1 stop8h 27m

$332

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Fri 4/24

5:01 pm-12:09 am

Nonstop6h 08m

Santiago Arturo Merino Benitez

Fri 5/1

12:59 am-6:23 am

Nonstop6h 24m

$333

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Thu 5/21

5:01 pm-12:09 am

Nonstop6h 08m

Santiago Arturo Merino Benitez

Mon 5/25

3:33 pm-2:07 pm

1 stop23h 34m

$339

MedellínSantiago

MDE - SCL

MDESCL

Medellín Jose Maria Cordova Intl

Thu 5/21

5:01 pm-12:09 am

Nonstop6h 08m

Santiago Arturo Merino Benitez

Mon 5/25

3:33 pm-2:54 pm

1 stop24h 21m

$340

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Medellín Jose Maria Cordova Intl Airport to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, March is the cheapest month to fly from Medellín Jose Maria Cordova Intl Airport to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $368. If you don’t want to visit Santiago in March, then you should wait until May to fly from Medellín Jose Maria Cordova Intl Airport, when ticket prices are also cheap, with an average price of $371.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Tuesday when prices can be found for as low as $297. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $495.

What is the cheapest time of day to depart on your flight to Santiago?

At noon is the cheapest time of day to fly from Medellín Jose Maria Cordova Intl Airport to Santiago when you can find flight prices for as low as $406. Flying to Santiago at noon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $518 per ticket.

What is the cheapest Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez flight route?

Fly from Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez for the best Medellín Jose Maria Cordova Intl - Santiago Arturo Merino Benitez flight prices

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Medellín Jose Maria Cordova Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $388 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Medellín Jose Maria Cordova Intl Airport for as low as $344 on momondo.

What cabin class options are available on Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez flights?

There is only 1 cabin class available to choose from on Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Medellín Jose Maria Cordova Intl Airport to Santiago flights?

No. A direct flight is the cheapest option for a flight between Medellín Jose Maria Cordova Intl Airport to Santiago.

How have Medellín Jose Maria Cordova Intl Airport to Santiago flight prices changed over time?

As of December 2025, prices for Medellín Jose Maria Cordova Intl Airport to Santiago flights are approximately 34% more expensive when compared to flights at the same time last year.

When to book flights from Medellín Jose Maria Cordova Intl Airport to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Medellín Jose Maria Cordova Intl Airport to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Medellín Jose Maria Cordova Intl Airport to Santiago (MDE to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Medellín Jose Maria Cordova Intl Airport to Santiago

Best Price Found

$235

Fastest flight time

6h 08m

Direct flights

Every day

Airports in Santiago

1 airport
The best one-way flight to Santiago from Medellín Jose Maria Cordova Intl Airport in the past 72 hours is $235. The best round-trip flight deal from Medellín Jose Maria Cordova Intl Airport to Santiago found on momondo in the last 72 hours is $297.
The fastest flight from Medellín Jose Maria Cordova Intl Airport to Santiago takes 6h 08m
Direct flights go from Medellín Jose Maria Cordova Intl Airport to Santiago every day.
There is 1 airport in Santiago. From Medellín Jose Maria Cordova Intl Airport there are direct flights to Santiago Arturo Merino Benitez (SCL).
Search flight deals

  • How far is Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez by plane?

    Medellín Jose Maria Cordova Intl and Santiago Arturo Merino Benitez are 2752.8 mi apart from one another. Typically, this will take 6h 08m by plane in normal conditions.

  • When did momondo last update prices for flights from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport are updated daily.

  • How many operators does momondo search for flights from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Medellín Jose Maria Cordova Intl Airport to Santiago?

  • What is the most popular airline from Medellín Jose Maria Cordova Intl Airport to Santiago?

Best airlines flying from Medellín Jose Maria Cordova Intl Airport to Santiago

Compare and see reviews for airlines that fly from Medellín Jose Maria Cordova Intl Airport to Santiago with momondo
Airline
Rating
Free Cancellation
Price
JetSMARTPriceFrom $168Free CancellationRating
6.6
255 reviews
Search JetSMART flights
Copa AirlinesPriceFrom $240Free CancellationRating
7.6
1,556 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $385Free CancellationRating
7.5
1,893 reviews
Search LATAM Airlines flights
AviancaPriceFrom $389Free CancellationRating
6.6
2,490 reviews
Search Avianca flights

  • JetSMART Flights From Medellín Jose Maria Cordova Intl Airport to Santiago

    JetSMART flies from Medellín Jose Maria Cordova Intl Airport to Santiago around 4 times per week, with 255 momondo users rating the airline 6.6/10. The cheapest JetSMART deal from Medellín Jose Maria Cordova Intl Airport to Santiago in the last 72 hours was $168 (round-trip), much lower than the average airfare cost of $380 for JetSMART flights on this route.

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Medellín to Santiago?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Medellín to Santiago. momondo saves you time and could save you money on your trip.

Can I find flights from Medellín to Santiago with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Medellín to Santiago flights to just show those with flexible booking policies.

How can momondo help me find flights from Medellín to Santiago?

Once all potential Medellín to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Medellín to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Medellín to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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