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Cheap flights from Columbus Airport to Santiago from $335

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbus Airport to Santiago departing on 1/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Columbus Airport to Santiago

Cheap round-trip flights

Multiple Airlines Logo
4:18 pm - 10:15 pmCMH-SCL
27h 57m3 stops
Multiple Airlines Logo
7:25 am - 8:47 amSCL-CMH
27h 22m2 stops
$726Multiple Airlines
Find Deal
jue., nov. 6 - vie., nov. 14
Multiple Airlines Logo
4:18 pm - 5:50 amCMH-SCL
35h 32m3 stops
Multiple Airlines Logo
7:25 am - 8:47 amSCL-CMH
27h 22m3 stops
$738Multiple Airlines
Find Deal
jue., nov. 6 - vie., nov. 14
LATAM Airlines Logo
12:28 pm - 6:55 amCMH-SCL
16h 27m1 stop
LATAM Airlines Logo
11:30 pm - 5:40 pmSCL-CMH
20h 10m1 stop
$770LATAM Airlines
Find Deal
jue., nov. 6 - vie., nov. 14
LATAM Airlines Logo
6:30 pm - 2:05 pmCMH-SCL
17h 35m2 stops
LATAM Airlines Logo
11:30 pm - 5:40 pmSCL-CMH
20h 10m1 stop
$786LATAM Airlines
Find Deal
jue., nov. 6 - vie., nov. 14
LATAM Airlines Logo
12:28 pm - 6:55 amCMH-SCL
16h 27m1 stop
LATAM Airlines Logo
12:50 am - 5:34 pmSCL-CMH
18h 44m2 stops
$788LATAM Airlines
Find Deal
jue., nov. 6 - jue., nov. 13
Air Canada Logo
9:30 am - 11:15 amCMH-SCL
24h 45m1 stop
Air Canada Logo
7:55 pm - 8:56 pmSCL-CMH
26h 01m1 stop
$882Air Canada
Find Deal
mar., mar. 17 - jue., mar. 19
Air Canada Logo
9:30 am - 12:15 pmCMH-SCL
24h 45m1 stop
Air Canada Logo
8:55 pm - 8:56 pmSCL-CMH
26h 01m1 stop
$892Air Canada
Find Deal
mié., feb. 11 - sáb., feb. 21
Copa Airlines Logo
10:30 am - 6:01 amCMH-SCL
17h 31m2 stops
Copa Airlines Logo
3:23 am - 9:49 amSCL-CMH
32h 26m2 stops
$1,003Copa Airlines
Find Deal
sáb., nov. 15 - sáb., nov. 22
Delta Logo
12:50 pm - 6:35 amCMH-SCL
16h 45m2 stops
Delta Logo
11:15 pm - 4:54 pmSCL-CMH
18h 39m1 stop
$1,094Delta
Find Deal
mar., mar. 17 - jue., mar. 19
Copa Airlines Logo
6:07 am - 12:34 amCMH-SCL
17h 27m2 stops
Copa Airlines Logo
2:34 am - 9:35 amSCL-CMH
31h 01m2 stops
$1,536Copa Airlines
Find Deal
sáb., mar. 28 - sáb., abr. 4

LATAM Airlines flights from Columbus Airport to Santiago

Our best LATAM Airlines deals on Columbus Airport to Santiago flight tickets
LATAM Airlines
Nov 6
CMH12:28 pmColumbus
16h 27m
1 stop
SCL6:55 amSantiago Arturo Merino Benitez
Nov 14
SCL11:30 pmSantiago Arturo Merino Benitez
20h 10m
1 stop
CMH5:40 pmColumbus
$770
Find similar
LATAM Airlines
Nov 6
CMH6:30 pmColumbus
17h 35m
2 stops
SCL2:05 pmSantiago Arturo Merino Benitez
Nov 14
SCL11:30 pmSantiago Arturo Merino Benitez
20h 10m
1 stop
CMH5:40 pmColumbus
$786
Find similar
LATAM Airlines
Nov 6
CMH12:28 pmColumbus
16h 27m
1 stop
SCL6:55 amSantiago Arturo Merino Benitez
Nov 13
SCL12:50 amSantiago Arturo Merino Benitez
18h 44m
2 stops
CMH5:34 pmColumbus
$788
Find similar

American Airlines flights from Columbus Airport to Santiago

Our best American Airlines deals on Columbus Airport to Santiago flight tickets
American Airlines
Oct 1
CMH6:40 amColumbus
24h 15m
1 stop
SCL7:55 amSantiago Arturo Merino Benitez
Oct 7
SCL9:55 pmSantiago Arturo Merino Benitez
25h 41m
1 stop
CMH10:36 pmColumbus
$1,079
Find similar
American Airlines
Oct 1
CMH6:30 pmColumbus
12h 25m
1 stop
SCL7:55 amSantiago Arturo Merino Benitez
Oct 7
SCL9:55 pmSantiago Arturo Merino Benitez
21h 50m
1 stop
CMH6:45 pmColumbus
$1,080
Find similar
American Airlines
Oct 1
CMH3:46 pmColumbus
15h 09m
2 stops
SCL7:55 amSantiago Arturo Merino Benitez
Oct 7
SCL9:55 pmSantiago Arturo Merino Benitez
18h 30m
2 stops
CMH3:25 pmColumbus
$1,084
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Columbus Airport to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated septiembre 29, 2025.
Use the filters below to find and compare flights from Columbus Airport to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

jue. 11/6

4:18 pm-10:15 pm

3 stops27h 57m

Santiago Arturo Merino Benitez

vie. 11/14

7:25 am-8:47 am

2 stops27h 22m

$726

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

jue. 11/6

4:18 pm-5:50 am

3 stops35h 32m

Santiago Arturo Merino Benitez

vie. 11/14

7:25 am-8:47 am

3 stops27h 22m

$738

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

jue. 11/6

12:28 pm-6:55 am

1 stop16h 27m

Santiago Arturo Merino Benitez

vie. 11/14

11:30 pm-5:40 pm

1 stop20h 10m

$770

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

jue. 11/6

6:30 pm-2:05 pm

2 stops17h 35m

Santiago Arturo Merino Benitez

vie. 11/14

11:30 pm-5:40 pm

1 stop20h 10m

$786

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

jue. 11/6

12:28 pm-6:55 am

1 stop16h 27m

Santiago Arturo Merino Benitez

jue. 11/13

12:50 am-5:34 pm

2 stops18h 44m

$788

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

mar. 3/17

9:30 am-11:15 am

1 stop24h 45m

Santiago Arturo Merino Benitez

jue. 3/19

7:55 pm-8:56 pm

1 stop26h 01m

$882

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

mié. 2/11

9:30 am-12:15 pm

1 stop24h 45m

Santiago Arturo Merino Benitez

sáb. 2/21

8:55 pm-8:56 pm

1 stop26h 01m

$892

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

sáb. 11/15

10:30 am-6:01 am

2 stops17h 31m

Santiago Arturo Merino Benitez

sáb. 11/22

3:23 am-9:49 am

2 stops32h 26m

$1,003

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

mar. 3/17

12:50 pm-6:35 am

2 stops16h 45m

Santiago Arturo Merino Benitez

jue. 3/19

11:15 pm-4:54 pm

1 stop18h 39m

$1,094

ColumbusSantiago

CMH - SCL

CMHSCL

Columbus

sáb. 3/28

6:07 am-12:34 am

2 stops17h 27m

Santiago Arturo Merino Benitez

sáb. 4/4

2:34 am-9:35 am

2 stops31h 01m

$1,536

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Columbus Airport to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, October is the cheapest month to fly from Columbus Airport to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $803. If you don’t want to visit Santiago in October, then you should wait until April to fly from Columbus Airport, when ticket prices are also cheap, with an average price of $848.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Tuesday when prices can be found for as low as $788. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,302.

What is the cheapest time of day to depart on your flight to Santiago?

In the afternoon is the cheapest time of day to fly from Columbus Airport to Santiago when you can find flight prices for as low as $952. Flying to Santiago in the afternoon is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,141 per ticket.

When to book flights from Columbus Airport to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Columbus Airport to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbus Airport to Santiago (CMH to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbus Airport to Santiago

Direct flights

None
There are no direct flights from Columbus Airport to Santiago. There are no popular flight routes from Columbus Airport to Santiago.
Search flight deals

  • How far is Columbus to Santiago Arturo Merino Benitez by plane?

    Columbus and Santiago Arturo Merino Benitez are 5130.9 mi apart from one another. In terms of flight time, this usually takes a little over 12h 13m.

  • When did momondo last update prices for flights from Columbus Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Columbus Airport to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Columbus Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Columbus Airport to Santiago Arturo Merino Benitez Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbus Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Columbus Airport to Santiago?

Best airlines flying from Columbus Airport to Santiago

Compare and see reviews for airlines that fly from Columbus Airport to Santiago with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $732Free CancellationRating
7.5
1,856 reviews
Search LATAM Airlines flights
DeltaPriceFrom $732Free CancellationRating
7.9
7,964 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Columbus to Santiago?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Columbus to Santiago for you.

Can I find flights from Columbus to Santiago with flexible booking policies on momondo?

Flights from Columbus to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Columbus to Santiago?

Once all potential Columbus to Santiago flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Columbus to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from Columbus. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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