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Cheap flights from Columbus Airport to Panama City from $299

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbus Airport to Panama City departing on 12/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Columbus Airport to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:30 am - 7:38 pm
CMH
-
PTY
13h 08m1 stop
United Airlines Logo
10:00 am - 7:31 pm
PTY
-
CMH
9h 31m1 stop
$414United Airlines
Mon, Jan 19 - Wed, Jan 28
United Airlines Logo
5:45 am - 7:38 pm
CMH
-
PTY
13h 53m2 stops
United Airlines Logo
10:00 am - 7:31 pm
PTY
-
CMH
9h 31m1 stop
$418United Airlines
Mon, Jan 19 - Wed, Jan 28
United Airlines Logo
6:30 am - 7:38 pm
CMH
-
PTY
13h 08m1 stop
United Airlines Logo
4:41 pm - 10:29 pm
PTY
-
CMH
29h 48m1 stop
$423United Airlines
Thu, Jan 22 - Mon, Jan 26
United Airlines Logo
5:30 am - 8:02 pm
CMH
-
PTY
14h 32m2 stops
United Airlines Logo
10:55 pm - 3:30 pm
PTY
-
CMH
15h 35m2 stops
$435United Airlines
Wed, Mar 4 - Sun, Mar 8
United Airlines Logo
9:00 am - 8:02 pm
CMH
-
PTY
11h 02m1 stop
United Airlines Logo
3:41 pm - 10:15 pm
PTY
-
CMH
29h 34m1 stop
$440United Airlines
Wed, Mar 4 - Sun, Mar 8
United Airlines Logo
6:10 am - 7:38 pm
CMH
-
PTY
13h 28m1 stop
United Airlines Logo
7:55 am - 10:15 pm
PTY
-
CMH
13h 20m1 stop
$448United Airlines
Sun, Mar 1 - Sat, Mar 14
United Airlines Logo
7:00 am - 8:02 pm
CMH
-
PTY
13h 02m2 stops
United Airlines Logo
8:55 am - 10:12 pm
PTY
-
CMH
13h 17m1 stop
$452United Airlines
Fri, Feb 6 - Fri, Feb 13
United Airlines Logo
9:20 am - 7:02 pm
CMH
-
PTY
10h 42m1 stop
United Airlines Logo
10:55 pm - 1:22 pm
PTY
-
CMH
13h 27m2 stops
$481United Airlines
Tue, Mar 17 - Sun, Mar 22
American Airlines Logo
7:27 pm - 3:15 pm
CMH
-
PTY
19h 48m2 stops
American Airlines Logo
2:50 pm - 12:33 pm
PTY
-
CMH
21h 43m2 stops
$485American Airlines
Fri, Feb 13 - Tue, Feb 17
United Airlines Logo
5:48 pm - 2:45 pm
CMH
-
PTY
20h 57m2 stops
United Airlines Logo
3:41 pm - 10:15 pm
PTY
-
CMH
29h 34m1 stop
$488United Airlines
Wed, Mar 4 - Sun, Mar 8

American Airlines flights from Columbus Airport to Panama City

Our best American Airlines deals on Columbus Airport to Panama City flight tickets
American Airlines
Feb 13
CMH7:27 pmColumbus
19h 48m
2 stops
PTY3:15 pmPanama City Tocumen Intl
Feb 17
PTY2:50 pmPanama City Tocumen Intl
21h 43m
2 stops
CMH12:33 pmColumbus
$485
Find similar
American Airlines
Feb 20
CMH6:32 pmColumbus
19h 18m
2 stops
PTY1:50 pmPanama City Tocumen Intl
Feb 23
PTY4:05 pmPanama City Tocumen Intl
18h 53m
2 stops
CMH10:58 amColumbus
$502
Find similar
American Airlines
Apr 2
CMH6:41 pmColumbus
20h 41m
2 stops
PTY2:22 pmPanama City Tocumen Intl
Apr 11
PTY1:55 pmPanama City Tocumen Intl
7h 25m
1 stop
CMH10:20 pmColumbus
$510
Find similar

United Airlines flights from Columbus Airport to Panama City

Our best United Airlines deals on Columbus Airport to Panama City flight tickets
United Airlines
Jan 19
CMH6:30 amColumbus
13h 08m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Jan 28
PTY10:00 amPanama City Tocumen Intl
9h 31m
1 stop
CMH7:31 pmColumbus
$414
Find similar
United Airlines
Jan 19
CMH5:45 amColumbus
13h 53m
2 stops
PTY7:38 pmPanama City Tocumen Intl
Jan 28
PTY10:00 amPanama City Tocumen Intl
10h 58m
1 stop
CMH8:58 pmColumbus
$418
Find similar
United Airlines
Jan 22
CMH6:30 amColumbus
13h 08m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Jan 26
PTY4:41 pmPanama City Tocumen Intl
29h 48m
1 stop
CMH10:29 pmColumbus
$423
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Columbus Airport to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Columbus Airport to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusPanama City

CMH - PTY

CMHPTY

Columbus

Mon 1/19

6:30 am-7:38 pm

1 stop13h 08m

Panama City Tocumen Intl

Wed 1/28

10:00 am-7:31 pm

1 stop9h 31m

$414

ColumbusPanama City

CMH - PTY

CMHPTY

Columbus

Mon 1/19

5:45 am-7:38 pm

2 stops13h 53m

Panama City Tocumen Intl

Wed 1/28

10:00 am-7:31 pm

1 stop9h 31m

$418

ColumbusPanama City

CMH - PTY

CMHPTY

Columbus

Thu 1/22

6:30 am-7:38 pm

1 stop13h 08m

Panama City Tocumen Intl

Mon 1/26

4:41 pm-10:29 pm

1 stop29h 48m

$423

ColumbusPanama City

CMH - PTY

CMHPTY

Columbus

Wed 3/4

5:30 am-8:02 pm

2 stops14h 32m

Panama City Tocumen Intl

Sun 3/8

10:55 pm-3:30 pm

2 stops15h 35m

$435

ColumbusPanama City

CMH - PTY

CMHPTY

Columbus

Wed 3/4

9:00 am-8:02 pm

1 stop11h 02m

Panama City Tocumen Intl

Sun 3/8

3:41 pm-10:15 pm

1 stop29h 34m

$440

ColumbusPanama City

CMH - PTY

CMHPTY

Columbus

Sun 3/1

6:10 am-7:38 pm

1 stop13h 28m

Panama City Tocumen Intl

Sat 3/14

7:55 am-10:15 pm

1 stop13h 20m

$448

ColumbusPanama City

CMH - PTY

CMHPTY

Columbus

Fri 2/6

7:00 am-8:02 pm

2 stops13h 02m

Panama City Tocumen Intl

Fri 2/13

8:55 am-10:12 pm

1 stop13h 17m

$452

ColumbusPanama City

CMH - PTY

CMHPTY

Columbus

Tue 3/17

9:20 am-7:02 pm

1 stop10h 42m

Panama City Tocumen Intl

Sun 3/22

10:55 pm-1:22 pm

2 stops13h 27m

$481

ColumbusPanama City

CMH - PTY

CMHPTY

Columbus

Fri 2/13

7:27 pm-3:15 pm

2 stops19h 48m

Panama City Tocumen Intl

Tue 2/17

2:50 pm-12:33 pm

2 stops21h 43m

$485

ColumbusPanama City

CMH - PTY

CMHPTY

Columbus

Wed 3/4

5:48 pm-2:45 pm

2 stops20h 57m

Panama City Tocumen Intl

Sun 3/8

3:41 pm-10:15 pm

1 stop29h 34m

$488

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Columbus Airport to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, October is the cheapest month to fly from Columbus Airport to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $472. If you’re not able to fly to Panama City in October, then July is your next best option. Flight prices from Columbus Airport to Panama City during July average around $511.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $483. If your travel schedule is flexible, try to avoid departing on a Thursday because tickets tend to average around $823. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Columbus Airport to Panama City during this time can be as low as $459. Try not to purchase tickets in the morning because they tend to be around $568. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Columbus Airport to Panama City flights?

You could potentially save up to 13% on your flight if you consider stops on a Columbus Airport to Panama City flight.

When to book flights from Columbus Airport to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Columbus Airport to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbus Airport to Panama City (CMH to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbus Airport to Panama City

Fastest flight time

8h 15m

Direct flights

None
The fastest flight from Columbus Airport to Panama City takes 8h 15m
There are no direct flights from Columbus Airport to Panama City. There are no popular flight routes from Columbus Airport to Panama City.
Search flight deals

  • How far is Columbus to Panama City Tocumen Intl by plane?

    There are 2151.5 mi between Columbus and Panama City Tocumen Intl. A reasonable flight in good conditions will take 8h 15m.

  • When did momondo last update prices for flights from Columbus Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Columbus Airport to Panama City Tocumen Intl Airport are updated daily.

  • How many operators does momondo search for flights from Columbus Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Columbus Airport to Panama City Tocumen Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbus Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The travel and health documents required for your trip to Panama City Tocumen Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City Tocumen Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Columbus Airport to Panama City?

Best airlines flying from Columbus Airport to Panama City

Compare and see reviews for airlines that fly from Columbus Airport to Panama City with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $393Free CancellationRating
7.9
8,014 reviews
Search Delta flights
American AirlinesPriceFrom $413Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
United AirlinesPriceFrom $430Free CancellationRating
7.4
9,105 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Columbus to Panama City?

Finding the right flight to Panama City from Columbus is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Columbus to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Columbus with this policy.

How can momondo help me find flights from Columbus to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Columbus to Panama City.

I’m not ready to book a flight from Columbus to Panama City right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Columbus to Panama City flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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