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Cheap flights from Detroit to Santiago de los Caballeros from $259

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago de los Caballeros departing on 4/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
8:00 am - 3:33 pm
DTW
-
STI
6h 33m1 stop
Spirit Airlines Logo
4:40 pm - 11:59 pm
STI
-
DTW
8h 19m1 stop
$313Spirit Airlines
vie., ene. 9 - vie., ene. 16
Multiple Airlines Logo
5:30 am - 3:33 pm
DTW
-
STI
9h 03m1 stop
Multiple Airlines Logo
4:40 pm - 2:00 pm
STI
-
DTW
22h 20m2 stops
$364Multiple Airlines
vie., ene. 9 - vie., ene. 16
Spirit Airlines Logo
6:40 pm - 2:42 am
DTW
-
STI
7h 02m1 stop
Spirit Airlines Logo
4:40 pm - 10:44 pm
STI
-
DTW
7h 04m1 stop
$394Spirit Airlines
sáb., ene. 3 - mar., ene. 13
Spirit Airlines Logo
6:40 pm - 2:42 am
DTW
-
STI
7h 02m1 stop
Spirit Airlines Logo
4:40 pm - 10:44 pm
STI
-
DTW
7h 04m1 stop
$401Spirit Airlines
vie., ene. 2 - mar., ene. 13
Spirit Airlines Logo
10:38 am - 2:42 am
DTW
-
STI
15h 04m2 stops
Spirit Airlines Logo
4:40 pm - 10:44 pm
STI
-
DTW
7h 04m1 stop
$429Spirit Airlines
sáb., ene. 3 - mar., ene. 13
Spirit Airlines Logo
10:38 am - 2:42 am
DTW
-
STI
15h 04m2 stops
Spirit Airlines Logo
4:40 pm - 10:44 pm
STI
-
DTW
7h 04m1 stop
$436Spirit Airlines
vie., ene. 2 - mar., ene. 13
Spirit Airlines Logo
5:05 am - 3:33 pm
DTW
-
STI
9h 28m2 stops
Spirit Airlines Logo
4:40 pm - 7:41 am
STI
-
DTW
16h 01m2 stops
$440Spirit Airlines
vie., ene. 9 - vie., ene. 16
Spirit Airlines Logo
10:38 am - 2:42 am
DTW
-
STI
15h 04m2 stops
Spirit Airlines Logo
4:40 pm - 7:41 am
STI
-
DTW
16h 01m2 stops
$460Spirit Airlines
sáb., ene. 3 - mar., ene. 13
Spirit Airlines Logo
6:15 am - 2:42 am
DTW
-
STI
19h 27m2 stops
Spirit Airlines Logo
4:40 pm - 7:41 am
STI
-
DTW
16h 01m2 stops
$467Spirit Airlines
vie., ene. 2 - mar., ene. 13
Spirit Airlines Logo
6:40 pm - 2:42 am
DTW
-
STI
7h 02m1 stop
Spirit Airlines Logo
4:40 pm - 10:20 am
STI
-
DTW
18h 40m2 stops
$468Spirit Airlines
sáb., ene. 3 - dom., ene. 11

JetBlue flights from Detroit to Santiago de los Caballeros

Our best JetBlue deals on Detroit to Santiago de los Caballeros flight tickets
JetBlue
Mar 26
DTW9:44 amDetroit Metropolitan Wayne County
11h 16m
2 stops
STI9:00 pmSantiago de los Caballeros
Apr 1
STI8:45 pmSantiago de los Caballeros
14h 00m
2 stops
DTW10:45 amDetroit Metropolitan Wayne County
$700
Find similar
JetBlue
Dec 25
DTW6:00 amDetroit Metropolitan Wayne County
13h 32m
1 stop
STI8:32 pmSantiago de los Caballeros
Dec 28
STI7:58 pmSantiago de los Caballeros
13h 37m
1 stop
DTW8:35 amDetroit Metropolitan Wayne County
$988
Find similar

American Airlines flights from Detroit to Santiago de los Caballeros

Our best American Airlines deals on Detroit to Santiago de los Caballeros flight tickets
American Airlines
Dec 29
DTW5:30 amDetroit Metropolitan Wayne County
10h 57m
1 stop
STI5:27 pmSantiago de los Caballeros
Jan 7
STI6:00 amSantiago de los Caballeros
18h 43m
2 stops
DTW11:43 pmDetroit Metropolitan Wayne County
$827
Find similar
American Airlines
Dec 29
DTW6:00 amDetroit Metropolitan Wayne County
10h 27m
2 stops
STI5:27 pmSantiago de los Caballeros
Jan 7
STI6:00 amSantiago de los Caballeros
18h 43m
2 stops
DTW11:43 pmDetroit Metropolitan Wayne County
$910
Find similar
American Airlines
Dec 20
DTW7:52 pmDetroit Metropolitan Wayne County
17h 32m
2 stops
STI2:24 pmSantiago de los Caballeros
Jan 9
STI6:00 amSantiago de los Caballeros
18h 43m
2 stops
DTW11:43 pmDetroit Metropolitan Wayne County
$957
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 11, 2025.
Use the filters below to find and compare flights from Detroit to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

vie. 1/9

8:00 am-3:33 pm

1 stop6h 33m

Santiago de los Caballeros

vie. 1/16

4:40 pm-11:59 pm

1 stop8h 19m

$313

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

vie. 1/9

5:30 am-3:33 pm

1 stop9h 03m

Santiago de los Caballeros

vie. 1/16

4:40 pm-2:00 pm

2 stops22h 20m

$364

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

sáb. 1/3

6:40 pm-2:42 am

1 stop7h 02m

Santiago de los Caballeros

mar. 1/13

4:40 pm-10:44 pm

1 stop7h 04m

$394

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

vie. 1/2

6:40 pm-2:42 am

1 stop7h 02m

Santiago de los Caballeros

mar. 1/13

4:40 pm-10:44 pm

1 stop7h 04m

$401

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

sáb. 1/3

10:38 am-2:42 am

2 stops15h 04m

Santiago de los Caballeros

mar. 1/13

4:40 pm-10:44 pm

1 stop7h 04m

$429

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

vie. 1/2

10:38 am-2:42 am

2 stops15h 04m

Santiago de los Caballeros

mar. 1/13

4:40 pm-10:44 pm

1 stop7h 04m

$436

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

vie. 1/9

5:05 am-3:33 pm

2 stops9h 28m

Santiago de los Caballeros

vie. 1/16

4:40 pm-7:41 am

2 stops16h 01m

$440

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

sáb. 1/3

10:38 am-2:42 am

2 stops15h 04m

Santiago de los Caballeros

mar. 1/13

4:40 pm-7:41 am

2 stops16h 01m

$460

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

vie. 1/2

6:15 am-2:42 am

2 stops19h 27m

Santiago de los Caballeros

mar. 1/13

4:40 pm-7:41 am

2 stops16h 01m

$467

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

sáb. 1/3

6:40 pm-2:42 am

1 stop7h 02m

Santiago de los Caballeros

dom. 1/11

4:40 pm-10:20 am

2 stops18h 40m

$468

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from Detroit to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago de los Caballeros?

The cheapest day to depart from Detroit to Santiago de los Caballeros is on a Tuesday when prices can be found for as low as $326. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Detroit to Santiago de los Caballeros for around $749.

What is the cheapest time of day to depart on your flight to Santiago de los Caballeros?

Our data shows that the cheapest Detroit to Santiago de los Caballeros flights are usually those with departure times in the afternoon. Our users have found flights to Santiago de los Caballeros in the afternoon for as low as $302. In the evening is when there is more demand to fly to Santiago de los Caballeros, so prices are often more expensive at around $749 per ticket.

When to book flights from Detroit to Santiago de los Caballeros

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago de los Caballeros according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago de los Caballeros (DTT to STI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago de los Caballeros

Fastest flight time

6h 27m

Direct flights

None
The fastest flight from Detroit to Santiago de los Caballeros takes 6h 27m
There are no direct flights from Detroit to Santiago de los Caballeros. There are no popular flight routes from Detroit to Santiago de los Caballeros.
Search flight deals

  • How far is Detroit to Santiago de los Caballeros by plane?

    The straight-line distance from Detroit to Santiago de los Caballeros is 1737.1 mi. Flights usually cover this in 6h 27m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit to Santiago de los Caballeros Airport?

    Prices for flights from Detroit to Santiago de los Caballeros Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from Detroit to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The required travel and health documents for your Santiago de los Caballeros Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago de los Caballeros Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Santiago de los Caballeros

Compare and see reviews for airlines that fly from Detroit to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $338Free CancellationRating
6.3
8,175 reviews
Search Spirit Airlines flights
JetBluePriceFrom $434Free CancellationRating
7.2
2,898 reviews
Search JetBlue flights
American AirlinesPriceFrom $500Free CancellationRating
7.2
11,048 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago de los Caballeros?

It is quick and easy to find Detroit to Santiago de los Caballeros flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago de los Caballeros that suits you.

Can I find flights from Detroit to Santiago de los Caballeros with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santiago de los Caballeros from Detroit with this policy.

How can momondo help me find flights from Detroit to Santiago de los Caballeros?

momondo provides multiple filters to help you find the best flight to Santiago de los Caballeros from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago de los Caballeros right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Santiago de los Caballeros flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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