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Cheap flights from Detroit to Santiago de los Caballeros from $151

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago de los Caballeros departing on 10/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Santiago de los Caballeros

Cheap round-trip flights

Spirit Airlines Logo
6:11 am - 5:06 pmDTW-STI
9h 55m1 stop
Spirit Airlines Logo
6:18 pm - 12:25 amSTI-DTW
7h 07m1 stop
$387Spirit Airlines
Find Deal
vie., nov. 7 - sáb., nov. 15
JetBlue Logo
12:16 pm - 12:24 amDTW-STI
12h 08m1 stop
JetBlue Logo
12:48 pm - 11:59 pmSTI-DTW
11h 11m1 stop
$405JetBlue
Find Deal
sáb., oct. 4 - mié., oct. 22
JetBlue Logo
12:16 pm - 2:16 amDTW-STI
14h 00m1 stop
JetBlue Logo
12:48 pm - 11:59 pmSTI-DTW
11h 11m1 stop
$407JetBlue
Find Deal
sáb., oct. 4 - mié., oct. 22
JetBlue Logo
12:16 pm - 2:16 amDTW-STI
14h 00m1 stop
JetBlue Logo
7:14 pm - 11:30 amSTI-DTW
16h 16m1 stop
$416JetBlue
Find Deal
sáb., oct. 4 - mié., oct. 22
American Airlines Logo
12:42 pm - 12:27 pmDTW-STI
23h 45m2 stops
American Airlines Logo
1:14 pm - 10:49 pmSTI-DTW
9h 35m2 stops
$729American Airlines
Find Deal
sáb., oct. 4 - mié., oct. 22
American Airlines Logo
12:42 pm - 12:27 pmDTW-STI
23h 45m2 stops
American Airlines Logo
1:14 pm - 11:25 pmSTI-DTW
10h 11m2 stops
$741American Airlines
Find Deal
sáb., oct. 4 - mié., oct. 22
United Airlines Logo
2:13 pm - 1:46 amDTW-STI
11h 33m2 stops
United Airlines Logo
6:00 am - 4:51 pmSTI-DTW
10h 51m2 stops
$839United Airlines
Find Deal
jue., oct. 2 - jue., oct. 9
Frontier Logo
1:48 pm - 10:14 amDTW-STI
19h 26m2 stops
Frontier Logo
11:34 am - 9:58 amSTI-DTW
23h 24m2 stops
$1,023Frontier
Find Deal
mar., dic. 30 - vie., ene. 2
Delta Logo
8:35 pm - 1:09 pmDTW-STI
15h 34m1 stop
Delta Logo
3:30 am - 6:23 pmSTI-DTW
15h 53m1 stop
$1,350Delta
Find Deal
mar., dic. 30 - jue., ene. 1
Delta Logo
8:35 pm - 1:09 pmDTW-STI
15h 34m1 stop
Delta Logo
3:30 am - 7:04 pmSTI-DTW
16h 34m2 stops
$1,355Delta
Find Deal
mar., dic. 30 - jue., ene. 1

American Airlines flights from Detroit to Santiago de los Caballeros

Our best American Airlines deals on Detroit to Santiago de los Caballeros flight tickets
American Airlines
Oct 4
DTW12:42 pmDetroit Metropolitan Wayne County
23h 45m
2 stops
STI12:27 pmSantiago de los Caballeros
Oct 22
STI1:14 pmSantiago de los Caballeros
9h 35m
2 stops
DTW10:49 pmDetroit Metropolitan Wayne County
$729
Find similar
American Airlines
Oct 4
DTW12:42 pmDetroit Metropolitan Wayne County
23h 45m
2 stops
STI12:27 pmSantiago de los Caballeros
Oct 22
STI1:14 pmSantiago de los Caballeros
10h 11m
2 stops
DTW11:25 pmDetroit Metropolitan Wayne County
$741
Find similar
American Airlines
Oct 4
DTW6:07 pmDetroit Metropolitan Wayne County
18h 20m
2 stops
STI12:27 pmSantiago de los Caballeros
Oct 22
STI1:14 pmSantiago de los Caballeros
10h 11m
2 stops
DTW11:25 pmDetroit Metropolitan Wayne County
$744
Find similar

Spirit Airlines flights from Detroit to Santiago de los Caballeros

Our best Spirit Airlines deals on Detroit to Santiago de los Caballeros flight tickets
Spirit Airlines
Nov 7
DTW6:11 amDetroit Metropolitan Wayne County
9h 55m
1 stop
STI5:06 pmSantiago de los Caballeros
Nov 15
STI6:18 pmSantiago de los Caballeros
7h 07m
1 stop
DTW12:25 amDetroit Metropolitan Wayne County
$387
Find similar
Spirit Airlines
Nov 7
DTW4:24 pmDetroit Metropolitan Wayne County
23h 42m
2 stops
STI5:06 pmSantiago de los Caballeros
Nov 15
STI6:18 pmSantiago de los Caballeros
7h 07m
1 stop
DTW12:25 amDetroit Metropolitan Wayne County
$423
Find similar
Spirit Airlines
Nov 7
DTW9:20 pmDetroit Metropolitan Wayne County
18h 46m
2 stops
STI5:06 pmSantiago de los Caballeros
Nov 15
STI6:18 pmSantiago de los Caballeros
14h 42m
2 stops
DTW8:00 amDetroit Metropolitan Wayne County
$459
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from Detroit to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

vie. 11/7

6:11 am-5:06 pm

1 stop9h 55m

Santiago de los Caballeros

sáb. 11/15

6:18 pm-12:25 am

1 stop7h 07m

$387

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

sáb. 10/4

12:16 pm-12:24 am

1 stop12h 08m

Santiago de los Caballeros

mié. 10/22

12:48 pm-11:59 pm

1 stop11h 11m

$405

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

sáb. 10/4

12:16 pm-2:16 am

1 stop14h 00m

Santiago de los Caballeros

mié. 10/22

12:48 pm-11:59 pm

1 stop11h 11m

$407

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

sáb. 10/4

12:16 pm-2:16 am

1 stop14h 00m

Santiago de los Caballeros

mié. 10/22

7:14 pm-11:30 am

1 stop16h 16m

$416

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

sáb. 10/4

12:42 pm-12:27 pm

2 stops23h 45m

Santiago de los Caballeros

mié. 10/22

1:14 pm-10:49 pm

2 stops9h 35m

$729

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

sáb. 10/4

12:42 pm-12:27 pm

2 stops23h 45m

Santiago de los Caballeros

mié. 10/22

1:14 pm-11:25 pm

2 stops10h 11m

$741

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

jue. 10/2

2:13 pm-1:46 am

2 stops11h 33m

Santiago de los Caballeros

jue. 10/9

6:00 am-4:51 pm

2 stops10h 51m

$839

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

mar. 12/30

1:48 pm-10:14 am

2 stops19h 26m

Santiago de los Caballeros

vie. 1/2

11:34 am-9:58 am

2 stops23h 24m

$1,023

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

mar. 12/30

8:35 pm-1:09 pm

1 stop15h 34m

Santiago de los Caballeros

jue. 1/1

3:30 am-6:23 pm

1 stop15h 53m

$1,350

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

mar. 12/30

8:35 pm-1:09 pm

1 stop15h 34m

Santiago de los Caballeros

jue. 1/1

3:30 am-7:04 pm

2 stops16h 34m

$1,355

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from Detroit to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Santiago de los Caballeros?

What is the cheapest day to depart on your flight to Santiago de los Caballeros?

The cheapest day to depart from Detroit to Santiago de los Caballeros is on a Tuesday when prices can be found for as low as $326. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Detroit to Santiago de los Caballeros for around $749.

What is the cheapest time of day to depart on your flight to Santiago de los Caballeros?

Our data shows that the cheapest Detroit to Santiago de los Caballeros flights are usually those with departure times in the afternoon. Our users have found flights to Santiago de los Caballeros in the afternoon for as low as $302. In the evening is when there is more demand to fly to Santiago de los Caballeros, so prices are often more expensive at around $749 per ticket.

When to book flights from Detroit to Santiago de los Caballeros

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago de los Caballeros according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago de los Caballeros (DTT to STI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago de los Caballeros

Direct flights

None
There are no direct flights from Detroit to Santiago de los Caballeros. There are no popular flight routes from Detroit to Santiago de los Caballeros.
Search flight deals

  • How far is Detroit to Santiago de los Caballeros by plane?

    The straight-line distance from Detroit to Santiago de los Caballeros is 1737.1 mi. Flights usually cover this in 6h 21m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit to Santiago de los Caballeros Airport?

    Prices for flights from Detroit to Santiago de los Caballeros Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from Detroit to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The required travel and health documents for your Santiago de los Caballeros Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago de los Caballeros Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Santiago de los Caballeros

Compare and see reviews for airlines that fly from Detroit to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $338Free CancellationRating
6.3
8,023 reviews
Search Spirit Airlines flights
JetBluePriceFrom $442Free CancellationRating
7.2
2,914 reviews
Search JetBlue flights
American AirlinesPriceFrom $500Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago de los Caballeros?

It is quick and easy to find Detroit to Santiago de los Caballeros flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago de los Caballeros that suits you.

Can I find flights from Detroit to Santiago de los Caballeros with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santiago de los Caballeros from Detroit with this policy.

How can momondo help me find flights from Detroit to Santiago de los Caballeros?

momondo provides multiple filters to help you find the best flight to Santiago de los Caballeros from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago de los Caballeros right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Santiago de los Caballeros flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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