Cheap flights from Detroit to Santiago de los Caballeros from $113

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago de los Caballeros departing on 3/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Santiago de los Caballeros

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
5:45 am - 3:35 pm
DTW
-
STI
8h 50m
1 stop
Spirit Airlines Logo
3:41 pm - 11:59 pm
STI
-
DTW
8h 18m
1 stop
$266Spirit Airlines
Wed, Mar 4 - Wed, Mar 11
Spirit Airlines Logo
6:50 pm - 1:49 am
DTW
-
STI
6h 59m
1 stop
Spirit Airlines Logo
2:46 am - 9:23 am
STI
-
DTW
6h 37m
1 stop
$324Spirit Airlines
Sat, Mar 21 - Fri, Mar 27
Spirit Airlines Logo
8:49 am - 3:35 pm
DTW
-
STI
5h 46m
1 stop
Spirit Airlines Logo
3:41 pm - 11:12 am
STI
-
DTW
19h 31m
2 stops
$325Spirit Airlines
Wed, Mar 4 - Wed, Mar 11
Spirit Airlines Logo
6:05 am - 1:49 am
DTW
-
STI
19h 44m
2 stops
Spirit Airlines Logo
2:46 am - 10:37 pm
STI
-
DTW
19h 51m
2 stops
$343Spirit Airlines
Sat, Mar 21 - Fri, Mar 27
Spirit Airlines Logo
6:50 pm - 1:49 am
DTW
-
STI
6h 59m
1 stop
Spirit Airlines Logo
2:46 am - 10:37 pm
STI
-
DTW
19h 51m
2 stops
$349Spirit Airlines
Sat, Mar 21 - Fri, Mar 27
Spirit Airlines Logo
10:59 pm - 3:35 pm
DTW
-
STI
15h 36m
3 stops
Spirit Airlines Logo
3:41 pm - 11:59 pm
STI
-
DTW
8h 18m
1 stop
$351Spirit Airlines
Wed, Mar 4 - Wed, Mar 11
Spirit Airlines Logo
5:34 pm - 2:35 pm
DTW
-
STI
21h 01m
2 stops
Spirit Airlines Logo
2:46 am - 10:37 pm
STI
-
DTW
19h 51m
3 stops
$376Spirit Airlines
Sat, Mar 21 - Fri, Mar 27
Spirit Airlines Logo
5:45 am - 3:35 pm
DTW
-
STI
8h 50m
1 stop
Spirit Airlines Logo
4:40 pm - 1:30 pm
STI
-
DTW
21h 50m
2 stops
$378Spirit Airlines
Thu, Feb 19 - Mon, Feb 23
Spirit Airlines Logo
10:59 pm - 3:35 pm
DTW
-
STI
15h 36m
3 stops
Spirit Airlines Logo
3:41 pm - 11:12 am
STI
-
DTW
19h 31m
2 stops
$382Spirit Airlines
Wed, Mar 4 - Wed, Mar 11
Spirit Airlines Logo
10:59 pm - 3:35 pm
DTW
-
STI
15h 36m
3 stops
Spirit Airlines Logo
3:41 pm - 3:50 pm
STI
-
DTW
24h 09m
3 stops
$398Spirit Airlines
Wed, Mar 4 - Wed, Mar 11

American Airlines flights from Detroit to Santiago de los Caballeros

Our best American Airlines deals on Detroit to Santiago de los Caballeros flight tickets
American Airlines
Mar 4
DTW7:30 amDetroit Metropolitan Wayne County
13h 00m
2 stops
STI9:30 pmSantiago de los Caballeros
Mar 11
STI1:30 pmSantiago de los Caballeros
11h 06m
2 stops
DTW12:36 amDetroit Metropolitan Wayne County
$668
American Airlines
Jun 19
DTW6:00 amDetroit Metropolitan Wayne County
15h 01m
2 stops
STI9:01 pmSantiago de los Caballeros
Jul 31
STI7:00 amSantiago de los Caballeros
16h 59m
1 stop
DTW11:59 pmDetroit Metropolitan Wayne County
$975

Delta flights from Detroit to Santiago de los Caballeros

Our best Delta deals on Detroit to Santiago de los Caballeros flight tickets
Delta
Jul 20
DTW4:10 pmDetroit Metropolitan Wayne County
8h 20m
1 stop
STI12:30 amSantiago de los Caballeros
Jul 29
STI6:15 amSantiago de los Caballeros
8h 48m
1 stop
DTW3:03 pmDetroit Metropolitan Wayne County
$657
Delta
Jul 20
DTW4:10 pmDetroit Metropolitan Wayne County
8h 20m
1 stop
STI12:30 amSantiago de los Caballeros
Jul 28
STI8:50 pmSantiago de los Caballeros
20h 20m
2 stops
DTW5:10 pmDetroit Metropolitan Wayne County
$661
Delta
Jul 20
DTW4:10 pmDetroit Metropolitan Wayne County
8h 20m
1 stop
STI12:30 amSantiago de los Caballeros
Jul 31
STI6:15 amSantiago de los Caballeros
15h 31m
1 stop
DTW9:46 pmDetroit Metropolitan Wayne County
$709

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 7, 2026.
Use the filters below to find and compare flights from Detroit to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

Wed 3/4

5:45 am-3:35 pm

1 stop8h 50m

Santiago de los Caballeros

Wed 3/11

3:41 pm-11:59 pm

1 stop8h 18m

$266

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

Sat 3/21

6:50 pm-1:49 am

1 stop6h 59m

Santiago de los Caballeros

Fri 3/27

2:46 am-9:23 am

1 stop6h 37m

$324

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

Wed 3/4

8:49 am-3:35 pm

1 stop5h 46m

Santiago de los Caballeros

Wed 3/11

3:41 pm-11:12 am

2 stops19h 31m

$325

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

Sat 3/21

6:05 am-1:49 am

2 stops19h 44m

Santiago de los Caballeros

Fri 3/27

2:46 am-10:37 pm

2 stops19h 51m

$343

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

Sat 3/21

6:50 pm-1:49 am

1 stop6h 59m

Santiago de los Caballeros

Fri 3/27

2:46 am-10:37 pm

2 stops19h 51m

$349

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

Wed 3/4

10:59 pm-3:35 pm

3 stops15h 36m

Santiago de los Caballeros

Wed 3/11

3:41 pm-11:59 pm

1 stop8h 18m

$351

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

Sat 3/21

5:34 pm-2:35 pm

2 stops21h 01m

Santiago de los Caballeros

Fri 3/27

2:46 am-10:37 pm

3 stops19h 51m

$376

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

Thu 2/19

5:45 am-3:35 pm

1 stop8h 50m

Santiago de los Caballeros

Mon 2/23

4:40 pm-1:30 pm

2 stops21h 50m

$378

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

Wed 3/4

10:59 pm-3:35 pm

3 stops15h 36m

Santiago de los Caballeros

Wed 3/11

3:41 pm-11:12 am

2 stops19h 31m

$382

DetroitSantiago de los Caballeros

DTW - STI

DTWSTI

Detroit Metropolitan Wayne County

Wed 3/4

10:59 pm-3:35 pm

3 stops15h 36m

Santiago de los Caballeros

Wed 3/11

3:41 pm-3:50 pm

3 stops24h 09m

$398

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Santiago de los Caballeros from

How to get the cheapest flight ticket from Detroit to Santiago de los Caballeros

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Detroit to Santiago de los Caballeros?

Spirit Airlines is the most popular carrier operating from Detroit to Santiago de los Caballeros

What airlines fly to Santiago de los Caballeros?

American Airlines, JetBlue and Spirit Airlines are the top three most popular airlines that fly to Santiago de los Caballeros from Detroit according to our data. American Airlines is the first choice among our users, with 31% of people opting to fly with this airline when traveling to Santiago de los Caballeros. Keep in mind that there are 4 different airlines that fly to Santiago de los Caballeros on a routine basis, so you have a few additional options to choose from.

When to book flights from Detroit to Santiago de los Caballeros

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago de los Caballeros according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago de los Caballeros (DTT to STI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago de los Caballeros

Fastest flight time

5h 46m

Direct flights

None
The fastest flight from Detroit to Santiago de los Caballeros takes 5h 46m
There are no direct flights from Detroit to Santiago de los Caballeros. There are no popular flight routes from Detroit to Santiago de los Caballeros.
  • How far is Detroit to Santiago de los Caballeros by plane?

    The straight-line distance from Detroit to Santiago de los Caballeros is 1737.1 mi. Flights usually cover this in 5h 46m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit to Santiago de los Caballeros Airport?

    Prices for flights from Detroit to Santiago de los Caballeros Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago de los Caballeros Airport?

  • How old do you have to be to fly from Detroit to Santiago de los Caballeros Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago de los Caballeros Airport.

  • What documentation or ID do you need to fly to Santiago de los Caballeros Airport?

    The required travel and health documents for your Santiago de los Caballeros Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago de los Caballeros Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Santiago de los Caballeros

Compare and see reviews for airlines that fly from Detroit to Santiago de los Caballeros with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $338Free CancellationRating
6.3
8,421 reviews
Search Spirit Airlines flights
JetBluePriceFrom $434Free CancellationRating
7.2
2,898 reviews
Search JetBlue flights
American AirlinesPriceFrom $500Free CancellationRating
7.2
11,247 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago de los Caballeros?

It is quick and easy to find Detroit to Santiago de los Caballeros flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago de los Caballeros that suits you.

Can I find flights from Detroit to Santiago de los Caballeros with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santiago de los Caballeros from Detroit with this policy.

How can momondo help me find flights from Detroit to Santiago de los Caballeros?

momondo provides multiple filters to help you find the best flight to Santiago de los Caballeros from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago de los Caballeros right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Santiago de los Caballeros flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Mon 3/9
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