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Cheap flights from Detroit to Santiago from $310

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago departing on 1/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:30 pm - 5:35 am
DTW
-
SCL
15h 05m1 stop
Multiple Airlines Logo
5:50 am - 11:16 am
SCL
-
DTW
31h 26m2 stops
$649Multiple Airlines
Thu, Jan 15 - Sun, Jan 25
Multiple Airlines Logo
6:35 am - 10:39 am
DTW
-
SCL
26h 04m3 stops
Multiple Airlines Logo
11:24 am - 1:30 pm
SCL
-
DTW
28h 06m3 stops
$664Multiple Airlines
Wed, Jan 14 - Sun, Jan 25
Multiple Airlines Logo
6:35 am - 10:39 am
DTW
-
SCL
26h 04m3 stops
Multiple Airlines Logo
11:24 am - 10:05 am
SCL
-
DTW
24h 41m2 stops
$676Multiple Airlines
Wed, Jan 14 - Sun, Jan 25
Multiple Airlines Logo
5:05 am - 2:40 pm
DTW
-
SCL
31h 35m3 stops
Multiple Airlines Logo
11:24 am - 10:05 am
SCL
-
DTW
24h 41m2 stops
$677Multiple Airlines
Thu, Jan 15 - Sun, Jan 25
Multiple Airlines Logo
5:30 am - 10:39 am
DTW
-
SCL
27h 09m2 stops
Multiple Airlines Logo
11:24 am - 10:05 am
SCL
-
DTW
24h 41m2 stops
$695Multiple Airlines
Wed, Jan 14 - Sun, Jan 25
Multiple Airlines Logo
8:00 am - 2:40 pm
DTW
-
SCL
28h 40m2 stops
Multiple Airlines Logo
11:24 am - 10:05 am
SCL
-
DTW
24h 41m2 stops
$696Multiple Airlines
Thu, Jan 15 - Sun, Jan 25
Multiple Airlines Logo
12:56 pm - 7:00 am
DTW
-
SCL
16h 04m1 stop
Multiple Airlines Logo
5:50 am - 9:46 am
SCL
-
DTW
29h 56m2 stops
$727Multiple Airlines
Fri, Jan 23 - Sun, Feb 15
Multiple Airlines Logo
5:05 am - 10:39 am
DTW
-
SCL
27h 34m3 stops
Multiple Airlines Logo
9:05 pm - 12:25 am
SCL
-
DTW
29h 20m3 stops
$728Multiple Airlines
Sat, Feb 7 - Sat, Feb 14
Multiple Airlines Logo
10:27 am - 5:35 am
DTW
-
SCL
17h 08m1 stop
Multiple Airlines Logo
6:30 pm - 1:11 pm
SCL
-
DTW
20h 41m2 stops
$734Multiple Airlines
Thu, Jan 8 - Wed, Jan 21
Multiple Airlines Logo
5:05 am - 2:40 pm
DTW
-
SCL
31h 35m3 stops
Multiple Airlines Logo
12:35 pm - 10:05 am
SCL
-
DTW
23h 30m2 stops
$735Multiple Airlines
Thu, Jan 29 - Thu, Feb 5

LATAM Airlines flights from Detroit to Santiago

Our best LATAM Airlines deals on Detroit to Santiago flight tickets
LATAM Airlines
Mar 24
DTW12:35 pmDetroit Metropolitan Wayne County
24h 35m
3 stops
SCL2:10 pmSantiago Arturo Merino Benitez
Apr 4
SCL6:40 amSantiago Arturo Merino Benitez
19h 03m
2 stops
DTW12:43 amDetroit Metropolitan Wayne County
$1,214
Find similar
LATAM Airlines
Dec 28
DTW8:35 pmDetroit Metropolitan Wayne County
32h 20m
1 stop
SCL6:55 amSantiago Arturo Merino Benitez
Dec 31
SCL9:30 pmSantiago Arturo Merino Benitez
14h 59m
1 stop
DTW10:29 amDetroit Metropolitan Wayne County
$1,675
Find similar
LATAM Airlines
Dec 22
DTW1:02 pmDetroit Metropolitan Wayne County
23h 28m
2 stops
SCL2:30 pmSantiago Arturo Merino Benitez
Jan 8
SCL11:10 pmSantiago Arturo Merino Benitez
13h 51m
1 stop
DTW11:01 amDetroit Metropolitan Wayne County
$1,856
Find similar

United Airlines flights from Detroit to Santiago

Our best United Airlines deals on Detroit to Santiago flight tickets
United Airlines
Jan 8
DTW10:56 amDetroit Metropolitan Wayne County
19h 54m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Jan 21
SCL10:45 pmSantiago Arturo Merino Benitez
17h 09m
1 stop
DTW1:54 pmDetroit Metropolitan Wayne County
$857
Find similar
United Airlines
Dec 23
DTW6:00 pmDetroit Metropolitan Wayne County
36h 50m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Dec 29
SCL10:45 pmSantiago Arturo Merino Benitez
25h 45m
2 stops
DTW10:30 pmDetroit Metropolitan Wayne County
$869
Find similar
United Airlines
Jan 31
DTW9:00 amDetroit Metropolitan Wayne County
21h 50m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Feb 15
SCL10:45 pmSantiago Arturo Merino Benitez
26h 59m
2 stops
DTW11:44 pmDetroit Metropolitan Wayne County
$946
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 1/15

12:30 pm-5:35 am

1 stop15h 05m

Santiago Arturo Merino Benitez

Sun 1/25

5:50 am-11:16 am

2 stops31h 26m

$649

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 1/14

6:35 am-10:39 am

3 stops26h 04m

Santiago Arturo Merino Benitez

Sun 1/25

11:24 am-1:30 pm

3 stops28h 06m

$664

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 1/14

6:35 am-10:39 am

3 stops26h 04m

Santiago Arturo Merino Benitez

Sun 1/25

11:24 am-10:05 am

2 stops24h 41m

$676

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 1/15

5:05 am-2:40 pm

3 stops31h 35m

Santiago Arturo Merino Benitez

Sun 1/25

11:24 am-10:05 am

2 stops24h 41m

$677

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 1/14

5:30 am-10:39 am

2 stops27h 09m

Santiago Arturo Merino Benitez

Sun 1/25

11:24 am-10:05 am

2 stops24h 41m

$695

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 1/15

8:00 am-2:40 pm

2 stops28h 40m

Santiago Arturo Merino Benitez

Sun 1/25

11:24 am-10:05 am

2 stops24h 41m

$696

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 1/23

12:56 pm-7:00 am

1 stop16h 04m

Santiago Arturo Merino Benitez

Sun 2/15

5:50 am-9:46 am

2 stops29h 56m

$727

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 2/7

5:05 am-10:39 am

3 stops27h 34m

Santiago Arturo Merino Benitez

Sat 2/14

9:05 pm-12:25 am

3 stops29h 20m

$728

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 1/8

10:27 am-5:35 am

1 stop17h 08m

Santiago Arturo Merino Benitez

Wed 1/21

6:30 pm-1:11 pm

2 stops20h 41m

$734

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 1/29

5:05 am-2:40 pm

3 stops31h 35m

Santiago Arturo Merino Benitez

Thu 2/5

12:35 pm-10:05 am

2 stops23h 30m

$735

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Detroit to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Santiago?

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Saturday when prices can be found for as low as $932. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,272.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from Detroit to Santiago when you can find flight prices for as low as $937. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,126 per ticket.

Can stopping save me money on Detroit to Santiago flights?

You could potentially save up to 11% on your flight if you consider stops on a Detroit to Santiago flight.

When to book flights from Detroit to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago (DTT to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago

Fastest flight time

17h 08m

Direct flights

None
The fastest flight from Detroit to Santiago takes 17h 08m
There are no direct flights from Detroit to Santiago. There are no popular flight routes from Detroit to Santiago.
Search flight deals

  • How far is Detroit to Santiago Arturo Merino Benitez by plane?

    The distance between Detroit and Santiago Arturo Merino Benitez is about 5291.2 mi. In terms of flight time, this usually takes a little over 17h 08m.

  • When did momondo last update prices for flights from Detroit to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Santiago?

Best airlines flying from Detroit to Santiago

Compare and see reviews for airlines that fly from Detroit to Santiago with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $733Free CancellationRating
7.5
1,891 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $808Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights
DeltaPriceFrom $873Free CancellationRating
7.9
8,009 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago?

It is quick and easy to find Detroit to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Detroit to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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