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Cheap flights from Detroit to Santiago from $399

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago departing on 2/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:59 pm - 4:00 amDTW-SCL
27h 01m3 stops
Multiple Airlines Logo
7:25 am - 7:49 amSCL-DTW
26h 24m3 stops
$654Multiple Airlines
Find Deal
Mon, Feb 23 - Tue, Mar 3
Multiple Airlines Logo
10:59 pm - 4:00 amDTW-SCL
27h 01m3 stops
Multiple Airlines Logo
9:10 pm - 9:41 pmSCL-DTW
26h 31m2 stops
$657Multiple Airlines
Find Deal
Mon, Feb 23 - Tue, Mar 3
Multiple Airlines Logo
10:59 pm - 4:55 amDTW-SCL
27h 56m2 stops
Multiple Airlines Logo
7:25 am - 7:41 amSCL-DTW
26h 16m3 stops
$660Multiple Airlines
Find Deal
Sat, Feb 28 - Fri, Mar 6
Multiple Airlines Logo
6:35 am - 5:30 amDTW-SCL
21h 55m2 stops
Multiple Airlines Logo
7:25 am - 11:49 pmSCL-DTW
17h 24m2 stops
$672Multiple Airlines
Find Deal
Tue, Mar 10 - Sat, Mar 21
Multiple Airlines Logo
2:06 pm - 10:15 pmDTW-SCL
31h 09m3 stops
Multiple Airlines Logo
1:35 am - 11:49 pmSCL-DTW
23h 14m3 stops
$682Multiple Airlines
Find Deal
Tue, Mar 10 - Fri, Mar 20
Multiple Airlines Logo
10:59 pm - 4:55 amDTW-SCL
27h 56m2 stops
Multiple Airlines Logo
12:40 am - 12:14 amSCL-DTW
25h 34m3 stops
$683Multiple Airlines
Find Deal
Sat, Feb 28 - Fri, Mar 6
Multiple Airlines Logo
5:05 am - 4:00 amDTW-SCL
21h 55m2 stops
Multiple Airlines Logo
1:35 am - 11:49 pmSCL-DTW
23h 14m3 stops
$691Multiple Airlines
Find Deal
Tue, Mar 10 - Fri, Mar 20
Multiple Airlines Logo
6:35 am - 5:30 amDTW-SCL
21h 55m2 stops
Multiple Airlines Logo
1:35 am - 10:34 pmSCL-DTW
21h 59m2 stops
$697Multiple Airlines
Find Deal
Tue, Mar 10 - Fri, Mar 20
Multiple Airlines Logo
2:06 pm - 12:15 pmDTW-SCL
20h 09m2 stops
Multiple Airlines Logo
9:10 pm - 9:41 pmSCL-DTW
26h 31m2 stops
$718Multiple Airlines
Find Deal
Mon, Feb 23 - Tue, Mar 3
Multiple Airlines Logo
6:00 am - 4:55 amDTW-SCL
44h 55m3 stops
Multiple Airlines Logo
7:25 am - 7:41 amSCL-DTW
26h 16m3 stops
$726Multiple Airlines
Find Deal
Sat, Feb 28 - Fri, Mar 6

LATAM Airlines flights from Detroit to Santiago

Our best LATAM Airlines deals on Detroit to Santiago flight tickets
LATAM Airlines
Dec 10
DTW4:40 pmDetroit Metropolitan Wayne County
13h 00m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Dec 17
SCL11:30 pmSantiago Arturo Merino Benitez
17h 39m
1 stop
DTW3:09 pmDetroit Metropolitan Wayne County
$864
Find similar
LATAM Airlines
Dec 23
DTW5:13 pmDetroit Metropolitan Wayne County
34h 57m
1 stop
SCL6:10 amSantiago Arturo Merino Benitez
Dec 30
SCL9:30 pmSantiago Arturo Merino Benitez
17h 09m
1 stop
DTW12:39 pmDetroit Metropolitan Wayne County
$929
Find similar
LATAM Airlines
Nov 15
DTW5:10 pmDetroit Metropolitan Wayne County
12h 30m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
Nov 21
SCL12:50 amSantiago Arturo Merino Benitez
19h 53m
2 stops
DTW6:43 pmDetroit Metropolitan Wayne County
$1,966
Find similar

American Airlines flights from Detroit to Santiago

Our best American Airlines deals on Detroit to Santiago flight tickets
American Airlines
May 5
DTW5:56 pmDetroit Metropolitan Wayne County
13h 09m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
May 12
SCL8:50 pmSantiago Arturo Merino Benitez
20h 29m
1 stop
DTW5:19 pmDetroit Metropolitan Wayne County
$904
Find similar
American Airlines
May 5
DTW2:54 pmDetroit Metropolitan Wayne County
16h 11m
2 stops
SCL7:05 amSantiago Arturo Merino Benitez
May 12
SCL8:50 pmSantiago Arturo Merino Benitez
15h 30m
2 stops
DTW12:20 pmDetroit Metropolitan Wayne County
$909
Find similar
American Airlines
Nov 15
DTW3:50 pmDetroit Metropolitan Wayne County
14h 05m
1 stop
SCL7:55 amSantiago Arturo Merino Benitez
Nov 22
SCL11:15 pmSantiago Arturo Merino Benitez
21h 31m
1 stop
DTW6:46 pmDetroit Metropolitan Wayne County
$1,214
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momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 2/23

10:59 pm-4:00 am

3 stops27h 01m

Santiago Arturo Merino Benitez

Tue 3/3

7:25 am-7:49 am

3 stops26h 24m

$654

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 2/23

10:59 pm-4:00 am

3 stops27h 01m

Santiago Arturo Merino Benitez

Tue 3/3

9:10 pm-9:41 pm

2 stops26h 31m

$657

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 2/28

10:59 pm-4:55 am

2 stops27h 56m

Santiago Arturo Merino Benitez

Fri 3/6

7:25 am-7:41 am

3 stops26h 16m

$660

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 3/10

6:35 am-5:30 am

2 stops21h 55m

Santiago Arturo Merino Benitez

Sat 3/21

7:25 am-11:49 pm

2 stops17h 24m

$672

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 3/10

2:06 pm-10:15 pm

3 stops31h 09m

Santiago Arturo Merino Benitez

Fri 3/20

1:35 am-11:49 pm

3 stops23h 14m

$682

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 2/28

10:59 pm-4:55 am

2 stops27h 56m

Santiago Arturo Merino Benitez

Fri 3/6

12:40 am-12:14 am

3 stops25h 34m

$683

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 3/10

5:05 am-4:00 am

2 stops21h 55m

Santiago Arturo Merino Benitez

Fri 3/20

1:35 am-11:49 pm

3 stops23h 14m

$691

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 3/10

6:35 am-5:30 am

2 stops21h 55m

Santiago Arturo Merino Benitez

Fri 3/20

1:35 am-10:34 pm

2 stops21h 59m

$697

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 2/23

2:06 pm-12:15 pm

2 stops20h 09m

Santiago Arturo Merino Benitez

Tue 3/3

9:10 pm-9:41 pm

2 stops26h 31m

$718

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 2/28

6:00 am-4:55 am

3 stops44h 55m

Santiago Arturo Merino Benitez

Fri 3/6

7:25 am-7:41 am

3 stops26h 16m

$726

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Santiago?

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Saturday when prices can be found for as low as $932. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,272.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from Detroit to Santiago when you can find flight prices for as low as $937. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,126 per ticket.

Can stopping save me money on Detroit to Santiago flights?

You could potentially save up to 3% on your flight if you consider stops on a Detroit to Santiago flight.

When to book flights from Detroit to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago (DTT to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago

Direct flights

None
There are no direct flights from Detroit to Santiago. There are no popular flight routes from Detroit to Santiago.
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  • How far is Detroit to Santiago Arturo Merino Benitez by plane?

    The distance between Detroit and Santiago Arturo Merino Benitez is about 5291.2 mi. In terms of flight time, this usually takes a little over 13h 00m.

  • When did momondo last update prices for flights from Detroit to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Santiago?

Best airlines flying from Detroit to Santiago

Compare and see reviews for airlines that fly from Detroit to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Air CanadaPriceFrom $684Free CancellationRating
7.1
10,448 reviews
Search Air Canada flights
LATAM AirlinesPriceFrom $733Free CancellationRating
7.5
1,876 reviews
Search LATAM Airlines flights
DeltaPriceFrom $768Free CancellationRating
7.9
8,007 reviews
Search Delta flights
American AirlinesPriceFrom $822Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago?

It is quick and easy to find Detroit to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Detroit to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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