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Cheap flights from Detroit to Santiago from $288

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago departing on 12/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:05 am - 5:30 amDTW-SCL
21h 25m2 stops
Multiple Airlines Logo
7:25 am - 11:49 pmSCL-DTW
17h 24m2 stops
$599Multiple Airlines
Find Deal
Wed, Mar 4 - Tue, Mar 17
Multiple Airlines Logo
2:06 pm - 2:40 pmDTW-SCL
46h 34m3 stops
Multiple Airlines Logo
12:35 pm - 7:51 pmSCL-DTW
32h 16m2 stops
$624Multiple Airlines
Find Deal
Wed, Mar 4 - Tue, Mar 17
Multiple Airlines Logo
2:17 pm - 10:15 pmDTW-SCL
30h 58m2 stops
Multiple Airlines Logo
7:15 am - 11:49 pmSCL-DTW
17h 34m2 stops
$633Multiple Airlines
Find Deal
Tue, Mar 10 - Tue, Mar 24
Multiple Airlines Logo
2:06 pm - 2:40 pmDTW-SCL
46h 34m3 stops
Multiple Airlines Logo
7:25 am - 3:42 pmSCL-DTW
33h 17m3 stops
$637Multiple Airlines
Find Deal
Wed, Mar 4 - Tue, Mar 17
Multiple Airlines Logo
12:22 pm - 6:40 amDTW-SCL
17h 18m2 stops
Multiple Airlines Logo
10:35 am - 11:49 pmSCL-DTW
14h 14m1 stop
$650Multiple Airlines
Find Deal
Mon, Mar 16 - Wed, Mar 18
Multiple Airlines Logo
6:05 am - 5:30 amDTW-SCL
21h 25m2 stops
Multiple Airlines Logo
1:35 am - 10:34 pmSCL-DTW
21h 59m2 stops
$651Multiple Airlines
Find Deal
Wed, Mar 4 - Mon, Mar 16
Multiple Airlines Logo
12:22 pm - 6:40 amDTW-SCL
17h 18m2 stops
Multiple Airlines Logo
7:15 am - 11:49 pmSCL-DTW
17h 34m2 stops
$667Multiple Airlines
Find Deal
Mon, Mar 16 - Mon, Mar 23
Multiple Airlines Logo
4:20 pm - 10:15 pmDTW-SCL
28h 55m2 stops
Multiple Airlines Logo
7:15 am - 11:49 pmSCL-DTW
17h 34m2 stops
$675Multiple Airlines
Find Deal
Thu, Mar 12 - Tue, Mar 24
Multiple Airlines Logo
4:20 pm - 6:50 amDTW-SCL
37h 30m2 stops
Multiple Airlines Logo
11:00 pm - 11:49 pmSCL-DTW
24h 49m1 stop
$679Multiple Airlines
Find Deal
Wed, Apr 1 - Sun, Apr 12
Multiple Airlines Logo
10:59 pm - 3:35 amDTW-SCL
27h 36m2 stops
Multiple Airlines Logo
11:25 pm - 7:51 pmSCL-DTW
21h 26m1 stop
$688Multiple Airlines
Find Deal
Wed, Mar 11 - Tue, Mar 24

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 25, 2025.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 3/4

6:05 am-5:30 am

2 stops21h 25m

Santiago Arturo Merino Benitez

Tue 3/17

7:25 am-11:49 pm

2 stops17h 24m

$599

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 3/4

2:06 pm-2:40 pm

3 stops46h 34m

Santiago Arturo Merino Benitez

Tue 3/17

12:35 pm-7:51 pm

2 stops32h 16m

$624

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 3/10

2:17 pm-10:15 pm

2 stops30h 58m

Santiago Arturo Merino Benitez

Tue 3/24

7:15 am-11:49 pm

2 stops17h 34m

$633

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 3/4

2:06 pm-2:40 pm

3 stops46h 34m

Santiago Arturo Merino Benitez

Tue 3/17

7:25 am-3:42 pm

3 stops33h 17m

$637

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 3/16

12:22 pm-6:40 am

2 stops17h 18m

Santiago Arturo Merino Benitez

Wed 3/18

10:35 am-11:49 pm

1 stop14h 14m

$650

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 3/4

6:05 am-5:30 am

2 stops21h 25m

Santiago Arturo Merino Benitez

Mon 3/16

1:35 am-10:34 pm

2 stops21h 59m

$651

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 3/16

12:22 pm-6:40 am

2 stops17h 18m

Santiago Arturo Merino Benitez

Mon 3/23

7:15 am-11:49 pm

2 stops17h 34m

$667

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 3/12

4:20 pm-10:15 pm

2 stops28h 55m

Santiago Arturo Merino Benitez

Tue 3/24

7:15 am-11:49 pm

2 stops17h 34m

$675

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 4/1

4:20 pm-6:50 am

2 stops37h 30m

Santiago Arturo Merino Benitez

Sun 4/12

11:00 pm-11:49 pm

1 stop24h 49m

$679

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 3/11

10:59 pm-3:35 am

2 stops27h 36m

Santiago Arturo Merino Benitez

Tue 3/24

11:25 pm-7:51 pm

1 stop21h 26m

$688

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Santiago?

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Saturday when prices can be found for as low as $932. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,272.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from Detroit to Santiago when you can find flight prices for as low as $937. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,126 per ticket.

Can stopping save me money on Detroit to Santiago flights?

You could potentially save up to 3% on your flight if you consider stops on a Detroit to Santiago flight.

When to book flights from Detroit to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago (DTT to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago

Fastest flight time

16h 00m

Direct flights

None
The fastest flight from Detroit to Santiago takes 16h 00m
There are no direct flights from Detroit to Santiago. There are no popular flight routes from Detroit to Santiago.
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  • How far is Detroit to Santiago Arturo Merino Benitez by plane?

    The distance between Detroit and Santiago Arturo Merino Benitez is about 5291.2 mi. In terms of flight time, this usually takes a little over 14h 43m.

  • When did momondo last update prices for flights from Detroit to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Santiago?

Best airlines flying from Detroit to Santiago

Compare and see reviews for airlines that fly from Detroit to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Air CanadaPriceFrom $684Free CancellationRating
7.1
10,471 reviews
Search Air Canada flights
LATAM AirlinesPriceFrom $733Free CancellationRating
7.5
1,887 reviews
Search LATAM Airlines flights
DeltaPriceFrom $768Free CancellationRating
7.9
7,998 reviews
Search Delta flights
American AirlinesPriceFrom $822Free CancellationRating
7.2
11,039 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago?

It is quick and easy to find Detroit to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Detroit to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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