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Cheap flights from Detroit to Santiago from $298

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago departing on 12/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:47 am - 5:55 amDTW-SCL
41h 08m3 stops
Multiple Airlines Logo
12:30 pm - 3:34 pmSCL-DTW
29h 04m2 stops
$590Multiple Airlines
Find Deal
Tue, Dec 2 - Thu, Dec 11
American Airlines Logo
7:15 am - 9:05 amDTW-SCL
23h 50m2 stops
American Airlines Logo
10:15 pm - 11:29 pmSCL-DTW
26h 14m2 stops
$614American Airlines
Find Deal
Thu, Feb 26 - Mon, Mar 9
Multiple Airlines Logo
10:47 am - 5:55 amDTW-SCL
41h 08m3 stops
Multiple Airlines Logo
9:10 pm - 11:59 pmSCL-DTW
28h 49m3 stops
$627Multiple Airlines
Find Deal
Tue, Dec 2 - Thu, Dec 11
Multiple Airlines Logo
10:08 pm - 4:55 amDTW-SCL
28h 47m2 stops
Multiple Airlines Logo
1:35 am - 9:41 pmSCL-DTW
22h 06m3 stops
$651Multiple Airlines
Find Deal
Sat, Feb 7 - Fri, Feb 20
Multiple Airlines Logo
6:00 am - 2:40 pmDTW-SCL
30h 40m3 stops
Multiple Airlines Logo
5:50 am - 10:12 pmSCL-DTW
18h 22m2 stops
$655Multiple Airlines
Find Deal
Fri, Jan 23 - Fri, Jan 30
United Airlines Logo
6:15 am - 8:50 amDTW-SCL
24h 35m1 stop
United Airlines Logo
9:45 pm - 1:41 pmSCL-DTW
16h 56m1 stop
$854United Airlines
Find Deal
Thu, Feb 26 - Tue, Mar 10
LATAM Airlines Logo
2:06 pm - 6:10 amDTW-SCL
14h 04m1 stop
LATAM Airlines Logo
4:35 am - 12:45 amSCL-DTW
22h 10m2 stops
$864LATAM Airlines
Find Deal
Tue, Jan 6 - Mon, Jan 19
United Airlines Logo
2:20 pm - 8:50 amDTW-SCL
16h 30m2 stops
United Airlines Logo
9:45 pm - 10:00 pmSCL-DTW
25h 15m2 stops
$909United Airlines
Find Deal
Mon, Mar 2 - Sun, Mar 8
LATAM Airlines Logo
7:59 pm - 2:30 pmDTW-SCL
40h 31m2 stops
LATAM Airlines Logo
9:30 pm - 9:09 amSCL-DTW
13h 39m1 stop
$939LATAM Airlines
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Tue, Dec 23 - Wed, Dec 31
Delta Logo
10:00 am - 6:55 amDTW-SCL
18h 55m1 stop
Delta Logo
11:25 pm - 3:20 pmSCL-DTW
16h 55m1 stop
$1,019Delta
Find Deal
Sat, Feb 28 - Tue, Mar 10

United Airlines flights from Detroit to Santiago

Our best United Airlines deals on Detroit to Santiago flight tickets
United Airlines
Feb 26
DTW6:15 amDetroit Metropolitan Wayne County
24h 35m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Mar 10
SCL9:45 pmSantiago Arturo Merino Benitez
16h 56m
1 stop
DTW1:41 pmDetroit Metropolitan Wayne County
$854
Find similar
United Airlines
Mar 2
DTW2:20 pmDetroit Metropolitan Wayne County
16h 30m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Mar 8
SCL9:45 pmSantiago Arturo Merino Benitez
25h 15m
2 stops
DTW10:00 pmDetroit Metropolitan Wayne County
$909
Find similar
United Airlines
Feb 27
DTW4:40 pmDetroit Metropolitan Wayne County
14h 10m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Mar 10
SCL9:45 pmSantiago Arturo Merino Benitez
19h 02m
1 stop
DTW3:47 pmDetroit Metropolitan Wayne County
$944
Find similar

American Airlines flights from Detroit to Santiago

Our best American Airlines deals on Detroit to Santiago flight tickets
American Airlines
Feb 26
DTW7:15 amDetroit Metropolitan Wayne County
23h 50m
2 stops
SCL9:05 amSantiago Arturo Merino Benitez
Mar 9
SCL10:15 pmSantiago Arturo Merino Benitez
26h 14m
2 stops
DTW11:29 pmDetroit Metropolitan Wayne County
$614
Find similar
American Airlines
Jan 6
DTW11:20 amDetroit Metropolitan Wayne County
18h 55m
1 stop
SCL8:15 amSantiago Arturo Merino Benitez
Jan 20
SCL10:35 pmSantiago Arturo Merino Benitez
14h 55m
1 stop
DTW11:30 amDetroit Metropolitan Wayne County
$734
Find similar
American Airlines
Jan 6
DTW11:20 amDetroit Metropolitan Wayne County
19h 40m
2 stops
SCL9:00 amSantiago Arturo Merino Benitez
Jan 20
SCL10:35 pmSantiago Arturo Merino Benitez
14h 55m
1 stop
DTW11:30 amDetroit Metropolitan Wayne County
$739
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 12/2

10:47 am-5:55 am

3 stops41h 08m

Santiago Arturo Merino Benitez

Thu 12/11

12:30 pm-3:34 pm

2 stops29h 04m

$590

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 2/26

7:15 am-9:05 am

2 stops23h 50m

Santiago Arturo Merino Benitez

Mon 3/9

10:15 pm-11:29 pm

2 stops26h 14m

$614

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 12/2

10:47 am-5:55 am

3 stops41h 08m

Santiago Arturo Merino Benitez

Thu 12/11

9:10 pm-11:59 pm

3 stops28h 49m

$627

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 2/7

10:08 pm-4:55 am

2 stops28h 47m

Santiago Arturo Merino Benitez

Fri 2/20

1:35 am-9:41 pm

3 stops22h 06m

$651

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 1/23

6:00 am-2:40 pm

3 stops30h 40m

Santiago Arturo Merino Benitez

Fri 1/30

5:50 am-10:12 pm

2 stops18h 22m

$655

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 2/26

6:15 am-8:50 am

1 stop24h 35m

Santiago Arturo Merino Benitez

Tue 3/10

9:45 pm-1:41 pm

1 stop16h 56m

$854

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 1/6

2:06 pm-6:10 am

1 stop14h 04m

Santiago Arturo Merino Benitez

Mon 1/19

4:35 am-12:45 am

2 stops22h 10m

$864

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 3/2

2:20 pm-8:50 am

2 stops16h 30m

Santiago Arturo Merino Benitez

Sun 3/8

9:45 pm-10:00 pm

2 stops25h 15m

$909

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 12/23

7:59 pm-2:30 pm

2 stops40h 31m

Santiago Arturo Merino Benitez

Wed 12/31

9:30 pm-9:09 am

1 stop13h 39m

$939

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 2/28

10:00 am-6:55 am

1 stop18h 55m

Santiago Arturo Merino Benitez

Tue 3/10

11:25 pm-3:20 pm

1 stop16h 55m

$1,019

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Saturday when prices can be found for as low as $932. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,272.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from Detroit to Santiago when you can find flight prices for as low as $937. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,126 per ticket.

Can stopping save me money on Detroit to Santiago flights?

You could potentially save up to 3% on your flight if you consider stops on a Detroit to Santiago flight.

When to book flights from Detroit to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago (DTT to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago

Direct flights

None
There are no direct flights from Detroit to Santiago. There are no popular flight routes from Detroit to Santiago.
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  • How far is Detroit to Santiago Arturo Merino Benitez by plane?

    The distance between Detroit and Santiago Arturo Merino Benitez is about 5291.2 mi. In terms of flight time, this usually takes a little over 14h 04m.

  • When did momondo last update prices for flights from Detroit to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Santiago?

Best airlines flying from Detroit to Santiago

Compare and see reviews for airlines that fly from Detroit to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Air CanadaPriceFrom $684Free CancellationRating
7.1
10,416 reviews
Search Air Canada flights
LATAM AirlinesPriceFrom $733Free CancellationRating
7.5
1,874 reviews
Search LATAM Airlines flights
DeltaPriceFrom $768Free CancellationRating
7.9
8,001 reviews
Search Delta flights
American AirlinesPriceFrom $822Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago?

It is quick and easy to find Detroit to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Detroit to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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