Cheap flights from Detroit to Santiago from $325

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago departing on 6/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:50 am - 5:10 am
DTW
-
SCL
22h 20m
3 stops
Multiple Airlines Logo
4:41 am - 11:40 am
SCL
-
DTW
30h 59m
3 stops
$866Multiple Airlines
Sat, Apr 25 - Sat, May 2
Multiple Airlines Logo
6:50 am - 11:20 pm
DTW
-
SCL
40h 30m
3 stops
Multiple Airlines Logo
4:50 pm - 7:02 pm
SCL
-
DTW
26h 12m
3 stops
$915Multiple Airlines
Wed, Apr 22 - Wed, Apr 29
Multiple Airlines Logo
6:10 am - 4:17 am
DTW
-
SCL
22h 07m
2 stops
Multiple Airlines Logo
4:50 pm - 7:02 pm
SCL
-
DTW
26h 12m
3 stops
$936Multiple Airlines
Wed, Apr 22 - Wed, Apr 29
Multiple Airlines Logo
6:00 am - 11:15 am
DTW
-
SCL
28h 15m
2 stops
Multiple Airlines Logo
6:00 am - 11:59 pm
SCL
-
DTW
18h 59m
2 stops
$953Multiple Airlines
Fri, Mar 27 - Mon, Mar 30
Multiple Airlines Logo
12:44 pm - 5:10 am
DTW
-
SCL
16h 26m
2 stops
Multiple Airlines Logo
10:55 pm - 10:52 pm
SCL
-
DTW
23h 57m
1 stop
$955Multiple Airlines
Tue, May 5 - Sat, May 9
United Airlines Logo
7:04 pm - 2:20 am
DTW
-
SCL
31h 16m
2 stops
United Airlines Logo
12:38 am - 11:54 am
SCL
-
DTW
35h 16m
2 stops
$961United Airlines
Mon, Apr 27 - Sun, May 3
American Airlines Logo
1:33 pm - 7:05 am
DTW
-
SCL
17h 32m
2 stops
American Airlines Logo
8:35 pm - 4:31 pm
SCL
-
DTW
19h 56m
2 stops
$963American Airlines
Wed, Apr 22 - Wed, Apr 29
American Airlines Logo
6:07 am - 7:05 am
DTW
-
SCL
24h 58m
1 stop
American Airlines Logo
8:35 pm - 2:50 pm
SCL
-
DTW
18h 15m
2 stops
$975American Airlines
Wed, Apr 22 - Wed, Apr 29
Multiple Airlines Logo
1:58 pm - 6:50 am
DTW
-
SCL
16h 52m
1 stop
Multiple Airlines Logo
11:35 am - 12:38 am
SCL
-
DTW
37h 03m
2 stops
$978Multiple Airlines
Wed, May 6 - Sat, May 9
Multiple Airlines Logo
9:55 pm - 4:45 am
DTW
-
SCL
30h 50m
2 stops
Multiple Airlines Logo
10:55 pm - 8:02 am
SCL
-
DTW
33h 07m
1 stop
$982Multiple Airlines
Sat, May 9 - Sun, May 17

United Airlines flights from Detroit to Santiago

Our best United Airlines deals on Detroit to Santiago flight tickets
United Airlines
Apr 27
DTW7:04 pmDetroit Metropolitan Wayne County
31h 16m
2 stops
SCL2:20 amSantiago Arturo Merino Benitez
May 3
SCL12:38 amSantiago Arturo Merino Benitez
35h 16m
2 stops
DTW11:54 amDetroit Metropolitan Wayne County
$961
United Airlines
May 11
DTW9:00 amDetroit Metropolitan Wayne County
18h 00m
2 stops
SCL3:00 amSantiago Arturo Merino Benitez
May 14
SCL12:38 amSantiago Arturo Merino Benitez
23h 09m
2 stops
DTW11:47 pmDetroit Metropolitan Wayne County
$1,016
United Airlines
May 5
DTW11:40 amDetroit Metropolitan Wayne County
17h 30m
2 stops
SCL5:10 amSantiago Arturo Merino Benitez
May 9
SCL11:17 amSantiago Arturo Merino Benitez
23h 37m
2 stops
DTW10:54 amDetroit Metropolitan Wayne County
$1,026

American Airlines flights from Detroit to Santiago

Our best American Airlines deals on Detroit to Santiago flight tickets
American Airlines
Apr 22
DTW1:33 pmDetroit Metropolitan Wayne County
17h 32m
2 stops
SCL7:05 amSantiago Arturo Merino Benitez
Apr 29
SCL8:35 pmSantiago Arturo Merino Benitez
19h 56m
2 stops
DTW4:31 pmDetroit Metropolitan Wayne County
$963
American Airlines
Apr 22
DTW6:07 amDetroit Metropolitan Wayne County
24h 58m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
Apr 29
SCL8:35 pmSantiago Arturo Merino Benitez
18h 15m
2 stops
DTW2:50 pmDetroit Metropolitan Wayne County
$975
American Airlines
May 6
DTW6:07 amDetroit Metropolitan Wayne County
24h 58m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
May 9
SCL8:35 pmSantiago Arturo Merino Benitez
27h 21m
1 stop
DTW11:56 pmDetroit Metropolitan Wayne County
$1,049

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 14, 2026.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 4/25

6:50 am-5:10 am

3 stops22h 20m

Santiago Arturo Merino Benitez

Sat 5/2

4:41 am-11:40 am

3 stops30h 59m

$866

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 4/22

6:50 am-11:20 pm

3 stops40h 30m

Santiago Arturo Merino Benitez

Wed 4/29

4:50 pm-7:02 pm

3 stops26h 12m

$915

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 4/22

6:10 am-4:17 am

2 stops22h 07m

Santiago Arturo Merino Benitez

Wed 4/29

4:50 pm-7:02 pm

3 stops26h 12m

$936

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 3/27

6:00 am-11:15 am

2 stops28h 15m

Santiago Arturo Merino Benitez

Mon 3/30

6:00 am-11:59 pm

2 stops18h 59m

$953

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 5/5

12:44 pm-5:10 am

2 stops16h 26m

Santiago Arturo Merino Benitez

Sat 5/9

10:55 pm-10:52 pm

1 stop23h 57m

$955

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 4/27

7:04 pm-2:20 am

2 stops31h 16m

Santiago Arturo Merino Benitez

Sun 5/3

12:38 am-11:54 am

2 stops35h 16m

$961
Quickest round-trip

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 4/22

1:33 pm-7:05 am

2 stops17h 32m

Santiago Arturo Merino Benitez

Wed 4/29

8:35 pm-4:31 pm

2 stops19h 56m

$963

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 4/22

6:07 am-7:05 am

1 stop24h 58m

Santiago Arturo Merino Benitez

Wed 4/29

8:35 pm-2:50 pm

2 stops18h 15m

$975

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 5/6

1:58 pm-6:50 am

1 stop16h 52m

Santiago Arturo Merino Benitez

Sat 5/9

11:35 am-12:38 am

2 stops37h 03m

$978

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 5/9

9:55 pm-4:45 am

2 stops30h 50m

Santiago Arturo Merino Benitez

Sun 5/17

10:55 pm-8:02 am

1 stop33h 07m

$982

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Santiago?

Can stopping save me money on Detroit to Santiago flights?

You could potentially save up to 23% on your flight if you consider stops on a Detroit to Santiago flight.

When to book flights from Detroit to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago (DTT to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago

Fastest flight time

16h 26m

Direct flights

None
The fastest flight from Detroit to Santiago takes 16h 26m
There are no direct flights from Detroit to Santiago. There are no popular flight routes from Detroit to Santiago.
  • How far is Detroit to Santiago Arturo Merino Benitez by plane?

    The distance between Detroit and Santiago Arturo Merino Benitez is about 5291.2 mi. In terms of flight time, this usually takes a little over 16h 26m.

  • When did momondo last update prices for flights from Detroit to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Santiago?

Best airlines flying from Detroit to Santiago

Compare and see reviews for airlines that fly from Detroit to Santiago with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $563Free CancellationRating
7.9
8,291 reviews
Search Delta flights
LATAM AirlinesPriceFrom $733Free CancellationRating
7.4
1,918 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

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Why should I use momondo to find a flight deal from Detroit to Santiago?

It is quick and easy to find Detroit to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

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1 adult
Mon 4/13
Mon 4/20

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