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Cheap flights from Detroit to Santiago from $280

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago departing on 1/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:00 am - 10:34 am
DTW
-
SCL
26h 34m3 stops
Multiple Airlines Logo
12:35 pm - 9:39 pm
SCL
-
DTW
35h 04m2 stops
$631Multiple Airlines
Tue, Feb 24 - Tue, Mar 3
Multiple Airlines Logo
8:49 am - 10:34 am
DTW
-
SCL
23h 45m2 stops
Multiple Airlines Logo
9:05 pm - 9:39 pm
SCL
-
DTW
26h 34m2 stops
$646Multiple Airlines
Tue, Feb 24 - Tue, Mar 3
Multiple Airlines Logo
9:18 am - 10:34 am
DTW
-
SCL
23h 16m3 stops
Multiple Airlines Logo
9:05 pm - 9:54 pm
SCL
-
DTW
26h 49m3 stops
$659Multiple Airlines
Tue, Feb 24 - Tue, Mar 3
Multiple Airlines Logo
6:36 pm - 5:14 am
DTW
-
SCL
32h 38m2 stops
Multiple Airlines Logo
11:25 pm - 9:39 pm
SCL
-
DTW
23h 14m1 stop
$676Multiple Airlines
Mon, Feb 23 - Mon, Mar 9
Multiple Airlines Logo
8:49 am - 5:14 am
DTW
-
SCL
18h 25m2 stops
Multiple Airlines Logo
11:25 pm - 9:39 pm
SCL
-
DTW
24h 14m1 stop
$678Multiple Airlines
Tue, Feb 24 - Tue, Mar 3
Multiple Airlines Logo
9:41 am - 5:15 am
DTW
-
SCL
18h 34m2 stops
Multiple Airlines Logo
11:55 pm - 9:34 pm
SCL
-
DTW
21h 39m2 stops
$689Multiple Airlines
Sat, Apr 4 - Wed, Apr 15
Multiple Airlines Logo
8:52 pm - 3:20 pm
DTW
-
SCL
40h 28m2 stops
Multiple Airlines Logo
11:25 pm - 7:57 pm
SCL
-
DTW
22h 32m1 stop
$696Multiple Airlines
Mon, Feb 16 - Mon, Feb 23
Multiple Airlines Logo
9:18 am - 6:40 am
DTW
-
SCL
19h 22m3 stops
Multiple Airlines Logo
9:05 pm - 9:54 pm
SCL
-
DTW
26h 49m3 stops
$701Multiple Airlines
Thu, Feb 5 - Thu, Feb 12
Multiple Airlines Logo
6:35 am - 5:30 am
DTW
-
SCL
20h 55m2 stops
Multiple Airlines Logo
4:25 pm - 9:11 am
SCL
-
DTW
18h 46m2 stops
$716Multiple Airlines
Wed, Feb 11 - Mon, Feb 16
Multiple Airlines Logo
5:30 am - 5:30 am
DTW
-
SCL
22h 00m2 stops
Multiple Airlines Logo
4:25 pm - 9:11 am
SCL
-
DTW
18h 46m2 stops
$728Multiple Airlines
Thu, Feb 5 - Thu, Feb 12

American Airlines flights from Detroit to Santiago

Our best American Airlines deals on Detroit to Santiago flight tickets
American Airlines
Jan 29
DTW11:20 amDetroit Metropolitan Wayne County
18h 55m
1 stop
SCL8:15 amSantiago Arturo Merino Benitez
Feb 10
SCL10:35 pmSantiago Arturo Merino Benitez
14h 55m
1 stop
DTW11:30 amDetroit Metropolitan Wayne County
$864
Find similar
American Airlines
Jan 29
DTW1:08 pmDetroit Metropolitan Wayne County
17h 52m
2 stops
SCL9:00 amSantiago Arturo Merino Benitez
Feb 10
SCL10:35 pmSantiago Arturo Merino Benitez
17h 26m
2 stops
DTW2:01 pmDetroit Metropolitan Wayne County
$869
Find similar
American Airlines
Feb 24
DTW2:10 pmDetroit Metropolitan Wayne County
17h 15m
2 stops
SCL9:25 amSantiago Arturo Merino Benitez
Jul 8
SCL8:50 pmSantiago Arturo Merino Benitez
20h 30m
2 stops
DTW5:20 pmDetroit Metropolitan Wayne County
$889
Find similar

United Airlines flights from Detroit to Santiago

Our best United Airlines deals on Detroit to Santiago flight tickets
United Airlines
Dec 25
DTW4:30 pmDetroit Metropolitan Wayne County
14h 20m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Dec 29
SCL10:45 pmSantiago Arturo Merino Benitez
19h 04m
1 stop
DTW3:49 pmDetroit Metropolitan Wayne County
$1,134
Find similar
United Airlines
Dec 25
DTW1:56 pmDetroit Metropolitan Wayne County
16h 54m
2 stops
SCL8:50 amSantiago Arturo Merino Benitez
Dec 29
SCL10:45 pmSantiago Arturo Merino Benitez
20h 32m
2 stops
DTW5:17 pmDetroit Metropolitan Wayne County
$1,139
Find similar
United Airlines
Dec 25
DTW4:30 pmDetroit Metropolitan Wayne County
14h 20m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Dec 30
SCL10:45 pmSantiago Arturo Merino Benitez
26h 58m
1 stop
DTW11:43 pmDetroit Metropolitan Wayne County
$1,145
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 2/24

6:00 am-10:34 am

3 stops26h 34m

Santiago Arturo Merino Benitez

Tue 3/3

12:35 pm-9:39 pm

2 stops35h 04m

$631

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 2/24

8:49 am-10:34 am

2 stops23h 45m

Santiago Arturo Merino Benitez

Tue 3/3

9:05 pm-9:39 pm

2 stops26h 34m

$646

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 2/24

9:18 am-10:34 am

3 stops23h 16m

Santiago Arturo Merino Benitez

Tue 3/3

9:05 pm-9:54 pm

3 stops26h 49m

$659

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 2/23

6:36 pm-5:14 am

2 stops32h 38m

Santiago Arturo Merino Benitez

Mon 3/9

11:25 pm-9:39 pm

1 stop23h 14m

$676

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 2/24

8:49 am-5:14 am

2 stops18h 25m

Santiago Arturo Merino Benitez

Tue 3/3

11:25 pm-9:39 pm

1 stop24h 14m

$678

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 4/4

9:41 am-5:15 am

2 stops18h 34m

Santiago Arturo Merino Benitez

Wed 4/15

11:55 pm-9:34 pm

2 stops21h 39m

$689

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 2/16

8:52 pm-3:20 pm

2 stops40h 28m

Santiago Arturo Merino Benitez

Mon 2/23

11:25 pm-7:57 pm

1 stop22h 32m

$696

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 2/5

9:18 am-6:40 am

3 stops19h 22m

Santiago Arturo Merino Benitez

Thu 2/12

9:05 pm-9:54 pm

3 stops26h 49m

$701

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Wed 2/11

6:35 am-5:30 am

2 stops20h 55m

Santiago Arturo Merino Benitez

Mon 2/16

4:25 pm-9:11 am

2 stops18h 46m

$716

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 2/5

5:30 am-5:30 am

2 stops22h 00m

Santiago Arturo Merino Benitez

Thu 2/12

4:25 pm-9:11 am

2 stops18h 46m

$728

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Detroit to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Saturday when prices can be found for as low as $932. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,272.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from Detroit to Santiago when you can find flight prices for as low as $937. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,126 per ticket.

Can stopping save me money on Detroit to Santiago flights?

You could potentially save up to 3% on your flight if you consider stops on a Detroit to Santiago flight.

When to book flights from Detroit to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago (DTT to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago

Fastest flight time

14h 20m

Direct flights

None
The fastest flight from Detroit to Santiago takes 14h 20m
There are no direct flights from Detroit to Santiago. There are no popular flight routes from Detroit to Santiago.
Search flight deals

  • How far is Detroit to Santiago Arturo Merino Benitez by plane?

    The distance between Detroit and Santiago Arturo Merino Benitez is about 5291.2 mi. In terms of flight time, this usually takes a little over 14h 20m.

  • When did momondo last update prices for flights from Detroit to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Santiago?

Best airlines flying from Detroit to Santiago

Compare and see reviews for airlines that fly from Detroit to Santiago with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $733Free CancellationRating
7.5
1,894 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $808Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights
DeltaPriceFrom $873Free CancellationRating
7.9
8,015 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago?

It is quick and easy to find Detroit to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Detroit to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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