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Cheap flights from Detroit to Santiago from $301

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago departing on 5/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:35 pm - 8:15 am
DTW
-
SCL
16h 40m2 stops
Multiple Airlines Logo
9:05 pm - 9:39 pm
SCL
-
DTW
25h 34m2 stops
$562Multiple Airlines
Fri, Mar 6 - Mon, Mar 9
Multiple Airlines Logo
1:35 pm - 8:15 am
DTW
-
SCL
16h 40m2 stops
Multiple Airlines Logo
11:25 pm - 9:39 pm
SCL
-
DTW
23h 14m1 stop
$582Multiple Airlines
Fri, Mar 6 - Mon, Mar 9
Multiple Airlines Logo
9:41 am - 5:30 am
DTW
-
SCL
18h 49m2 stops
Multiple Airlines Logo
7:10 am - 11:41 pm
SCL
-
DTW
17h 31m2 stops
$682Multiple Airlines
Tue, Mar 17 - Wed, Apr 1
Multiple Airlines Logo
6:35 am - 5:30 am
DTW
-
SCL
20h 55m2 stops
Multiple Airlines Logo
1:35 am - 11:59 pm
SCL
-
DTW
24h 24m2 stops
$737Multiple Airlines
Sat, Jan 24 - Wed, Feb 4
Multiple Airlines Logo
8:52 pm - 3:20 pm
DTW
-
SCL
40h 28m2 stops
Multiple Airlines Logo
11:25 pm - 9:39 pm
SCL
-
DTW
24h 14m1 stop
$759Multiple Airlines
Fri, Feb 20 - Fri, Feb 27
Multiple Airlines Logo
6:00 am - 6:40 am
DTW
-
SCL
22h 40m3 stops
Multiple Airlines Logo
12:35 pm - 10:08 pm
SCL
-
DTW
35h 33m3 stops
$780Multiple Airlines
Sat, Jan 24 - Thu, Feb 5
Multiple Airlines Logo
6:00 am - 6:40 am
DTW
-
SCL
22h 40m3 stops
Multiple Airlines Logo
12:35 pm - 10:05 am
SCL
-
DTW
23h 30m2 stops
$791Multiple Airlines
Sat, Jan 24 - Thu, Feb 5
Multiple Airlines Logo
9:59 pm - 5:55 am
DTW
-
SCL
30h 56m1 stop
Multiple Airlines Logo
10:05 pm - 10:03 pm
SCL
-
DTW
24h 58m2 stops
$849Multiple Airlines
Tue, Mar 17 - Wed, Apr 1
American Airlines Logo
11:20 am - 8:15 am
DTW
-
SCL
18h 55m1 stop
American Airlines Logo
10:30 pm - 4:32 pm
SCL
-
DTW
20h 02m1 stop
$865American Airlines
Thu, Jan 29 - Tue, Feb 10
American Airlines Logo
11:48 am - 9:00 am
DTW
-
SCL
19h 12m2 stops
American Airlines Logo
10:35 pm - 12:21 pm
SCL
-
DTW
15h 46m2 stops
$870American Airlines
Thu, Jan 29 - Tue, Feb 10

American Airlines flights from Detroit to Santiago

Our best American Airlines deals on Detroit to Santiago flight tickets
American Airlines
Jan 29
DTW11:20 amDetroit Metropolitan Wayne County
18h 55m
1 stop
SCL8:15 amSantiago Arturo Merino Benitez
Feb 10
SCL10:30 pmSantiago Arturo Merino Benitez
20h 02m
1 stop
DTW4:32 pmDetroit Metropolitan Wayne County
$865
American Airlines
Jan 29
DTW11:48 amDetroit Metropolitan Wayne County
19h 12m
2 stops
SCL9:00 amSantiago Arturo Merino Benitez
Feb 10
SCL10:35 pmSantiago Arturo Merino Benitez
15h 46m
2 stops
DTW12:21 pmDetroit Metropolitan Wayne County
$870
American Airlines
Feb 24
DTW10:30 amDetroit Metropolitan Wayne County
19h 35m
2 stops
SCL8:05 amSantiago Arturo Merino Benitez
Jul 8
SCL8:30 pmSantiago Arturo Merino Benitez
19h 04m
2 stops
DTW3:34 pmDetroit Metropolitan Wayne County
$887

United Airlines flights from Detroit to Santiago

Our best United Airlines deals on Detroit to Santiago flight tickets
United Airlines
Mar 23
DTW10:55 amDetroit Metropolitan Wayne County
19h 55m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Mar 25
SCL9:45 pmSantiago Arturo Merino Benitez
19h 16m
1 stop
DTW4:01 pmDetroit Metropolitan Wayne County
$873
United Airlines
Mar 23
DTW4:42 pmDetroit Metropolitan Wayne County
14h 08m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Mar 25
SCL9:45 pmSantiago Arturo Merino Benitez
16h 43m
2 stops
DTW1:28 pmDetroit Metropolitan Wayne County
$878
United Airlines
Jan 15
DTW4:38 pmDetroit Metropolitan Wayne County
14h 12m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Jan 22
SCL10:45 pmSantiago Arturo Merino Benitez
17h 09m
1 stop
DTW1:54 pmDetroit Metropolitan Wayne County
$1,007

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 3/6

1:35 pm-8:15 am

2 stops16h 40m

Santiago Arturo Merino Benitez

Mon 3/9

9:05 pm-9:39 pm

2 stops25h 34m

$562

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 3/6

1:35 pm-8:15 am

2 stops16h 40m

Santiago Arturo Merino Benitez

Mon 3/9

11:25 pm-9:39 pm

1 stop23h 14m

$582

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 3/17

9:41 am-5:30 am

2 stops18h 49m

Santiago Arturo Merino Benitez

Wed 4/1

7:10 am-11:41 pm

2 stops17h 31m

$682

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 1/24

6:35 am-5:30 am

2 stops20h 55m

Santiago Arturo Merino Benitez

Wed 2/4

1:35 am-11:59 pm

2 stops24h 24m

$737

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 2/20

8:52 pm-3:20 pm

2 stops40h 28m

Santiago Arturo Merino Benitez

Fri 2/27

11:25 pm-9:39 pm

1 stop24h 14m

$759

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 1/24

6:00 am-6:40 am

3 stops22h 40m

Santiago Arturo Merino Benitez

Thu 2/5

12:35 pm-10:08 pm

3 stops35h 33m

$780

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 1/24

6:00 am-6:40 am

3 stops22h 40m

Santiago Arturo Merino Benitez

Thu 2/5

12:35 pm-10:05 am

2 stops23h 30m

$791

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 3/17

9:59 pm-5:55 am

1 stop30h 56m

Santiago Arturo Merino Benitez

Wed 4/1

10:05 pm-10:03 pm

2 stops24h 58m

$849

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 1/29

11:20 am-8:15 am

1 stop18h 55m

Santiago Arturo Merino Benitez

Tue 2/10

10:30 pm-4:32 pm

1 stop20h 02m

$865

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 1/29

11:48 am-9:00 am

2 stops19h 12m

Santiago Arturo Merino Benitez

Tue 2/10

10:35 pm-12:21 pm

2 stops15h 46m

$870

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Santiago?

Can stopping save me money on Detroit to Santiago flights?

You could potentially save up to 3% on your flight if you consider stops on a Detroit to Santiago flight.

When to book flights from Detroit to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago (DTT to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago

Fastest flight time

14h 40m

Direct flights

None
The fastest flight from Detroit to Santiago takes 14h 40m
There are no direct flights from Detroit to Santiago. There are no popular flight routes from Detroit to Santiago.
Search flight deals

  • How far is Detroit to Santiago Arturo Merino Benitez by plane?

    The distance between Detroit and Santiago Arturo Merino Benitez is about 5291.2 mi. In terms of flight time, this usually takes a little over 14h 40m.

  • When did momondo last update prices for flights from Detroit to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Santiago?

Best airlines flying from Detroit to Santiago

Compare and see reviews for airlines that fly from Detroit to Santiago with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $733Free CancellationRating
7.5
1,898 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $808Free CancellationRating
7.2
11,095 reviews
Search American Airlines flights
DeltaPriceFrom $873Free CancellationRating
7.9
8,029 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago?

It is quick and easy to find Detroit to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Detroit to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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