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Cheap flights from Detroit to Santiago from $307

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago departing on 2/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:45 am - 3:20 pm
DTW
-
SCL
31h 35m
2 stops
Multiple Airlines Logo
11:25 pm - 8:31 am
SCL
-
DTW
35h 06m
1 stop
$666Multiple Airlines
Tue, Feb 17 - Tue, Feb 24
Multiple Airlines Logo
8:49 am - 9:55 pm
DTW
-
SCL
35h 06m
2 stops
Multiple Airlines Logo
4:20 am - 11:16 am
SCL
-
DTW
32h 56m
2 stops
$708Multiple Airlines
Fri, Feb 27 - Thu, Mar 5
Multiple Airlines Logo
5:45 am - 9:55 pm
DTW
-
SCL
38h 10m
2 stops
Multiple Airlines Logo
10:35 am - 9:46 am
SCL
-
DTW
25h 11m
1 stop
$755Multiple Airlines
Fri, Feb 20 - Sun, Mar 1
Multiple Airlines Logo
7:15 am - 7:40 am
DTW
-
SCL
46h 25m
2 stops
Multiple Airlines Logo
11:25 pm - 8:31 am
SCL
-
DTW
35h 06m
1 stop
$758Multiple Airlines
Sun, Feb 15 - Tue, Feb 24
Multiple Airlines Logo
5:45 am - 3:20 pm
DTW
-
SCL
31h 35m
2 stops
Multiple Airlines Logo
11:25 pm - 7:52 pm
SCL
-
DTW
22h 27m
1 stop
$763Multiple Airlines
Tue, Feb 17 - Mon, Feb 23
Multiple Airlines Logo
9:18 am - 6:55 am
DTW
-
SCL
19h 37m
1 stop
Multiple Airlines Logo
9:05 pm - 10:43 pm
SCL
-
DTW
27h 38m
2 stops
$773Multiple Airlines
Tue, Feb 17 - Wed, Feb 18
Multiple Airlines Logo
4:50 pm - 1:40 pm
DTW
-
SCL
19h 50m
2 stops
Multiple Airlines Logo
8:15 pm - 11:59 pm
SCL
-
DTW
27h 44m
2 stops
$784Multiple Airlines
Tue, Mar 31 - Tue, Apr 7
Multiple Airlines Logo
7:28 pm - 4:00 am
DTW
-
SCL
30h 32m
2 stops
Multiple Airlines Logo
11:25 pm - 8:31 am
SCL
-
DTW
35h 06m
1 stop
$788Multiple Airlines
Mon, Feb 16 - Tue, Feb 24
Multiple Airlines Logo
11:05 am - 5:30 am
DTW
-
SCL
40h 25m
2 stops
Multiple Airlines Logo
11:25 pm - 11:59 pm
SCL
-
DTW
25h 34m
1 stop
$797Multiple Airlines
Sun, Mar 1 - Sun, Mar 15
Multiple Airlines Logo
4:50 pm - 1:40 pm
DTW
-
SCL
19h 50m
2 stops
Multiple Airlines Logo
4:55 am - 7:46 pm
SCL
-
DTW
38h 51m
2 stops
$807Multiple Airlines
Mon, Mar 30 - Tue, Apr 7

United Airlines flights from Detroit to Santiago

Our best United Airlines deals on Detroit to Santiago flight tickets
United Airlines
Feb 12
DTW8:05 amDetroit Metropolitan Wayne County
22h 45m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Feb 19
SCL10:45 pmSantiago Arturo Merino Benitez
19h 11m
1 stop
DTW3:56 pmDetroit Metropolitan Wayne County
$858
United Airlines
Feb 12
DTW8:05 amDetroit Metropolitan Wayne County
22h 45m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Feb 19
SCL10:45 pmSantiago Arturo Merino Benitez
27h 09m
2 stops
DTW11:54 pmDetroit Metropolitan Wayne County
$863
United Airlines
Feb 16
DTW4:40 pmDetroit Metropolitan Wayne County
14h 10m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Feb 24
SCL10:45 pmSantiago Arturo Merino Benitez
17h 04m
1 stop
DTW1:49 pmDetroit Metropolitan Wayne County
$878

American Airlines flights from Detroit to Santiago

Our best American Airlines deals on Detroit to Santiago flight tickets
American Airlines
Feb 24
DTW7:30 amDetroit Metropolitan Wayne County
22h 35m
1 stop
SCL8:05 amSantiago Arturo Merino Benitez
Jul 8
SCL8:30 pmSantiago Arturo Merino Benitez
19h 04m
2 stops
DTW3:34 pmDetroit Metropolitan Wayne County
$897
American Airlines
May 10
DTW5:57 pmDetroit Metropolitan Wayne County
12h 58m
1 stop
SCL6:55 amSantiago Arturo Merino Benitez
May 20
SCL8:30 pmSantiago Arturo Merino Benitez
22h 52m
2 stops
DTW7:22 pmDetroit Metropolitan Wayne County
$903
American Airlines
Feb 24
DTW7:30 amDetroit Metropolitan Wayne County
22h 35m
1 stop
SCL8:05 amSantiago Arturo Merino Benitez
Jul 8
SCL8:30 pmSantiago Arturo Merino Benitez
27h 29m
1 stop
DTW11:59 pmDetroit Metropolitan Wayne County
$904

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 2/17

5:45 am-3:20 pm

2 stops31h 35m

Santiago Arturo Merino Benitez

Tue 2/24

11:25 pm-8:31 am

1 stop35h 06m

$666

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 2/27

8:49 am-9:55 pm

2 stops35h 06m

Santiago Arturo Merino Benitez

Thu 3/5

4:20 am-11:16 am

2 stops32h 56m

$708

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 2/20

5:45 am-9:55 pm

2 stops38h 10m

Santiago Arturo Merino Benitez

Sun 3/1

10:35 am-9:46 am

1 stop25h 11m

$755

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sun 2/15

7:15 am-7:40 am

2 stops46h 25m

Santiago Arturo Merino Benitez

Tue 2/24

11:25 pm-8:31 am

1 stop35h 06m

$758

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 2/17

5:45 am-3:20 pm

2 stops31h 35m

Santiago Arturo Merino Benitez

Mon 2/23

11:25 pm-7:52 pm

1 stop22h 27m

$763

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 2/17

9:18 am-6:55 am

1 stop19h 37m

Santiago Arturo Merino Benitez

Wed 2/18

9:05 pm-10:43 pm

2 stops27h 38m

$773

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 3/31

4:50 pm-1:40 pm

2 stops19h 50m

Santiago Arturo Merino Benitez

Tue 4/7

8:15 pm-11:59 pm

2 stops27h 44m

$784

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 2/16

7:28 pm-4:00 am

2 stops30h 32m

Santiago Arturo Merino Benitez

Tue 2/24

11:25 pm-8:31 am

1 stop35h 06m

$788

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sun 3/1

11:05 am-5:30 am

2 stops40h 25m

Santiago Arturo Merino Benitez

Sun 3/15

11:25 pm-11:59 pm

1 stop25h 34m

$797

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Mon 3/30

4:50 pm-1:40 pm

2 stops19h 50m

Santiago Arturo Merino Benitez

Tue 4/7

4:55 am-7:46 pm

2 stops38h 51m

$807

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Detroit to Santiago flights?

You could potentially save up to 3% on your flight if you consider stops on a Detroit to Santiago flight.

When to book flights from Detroit to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago (DTT to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago

Fastest flight time

14h 12m

Direct flights

None
The fastest flight from Detroit to Santiago takes 14h 12m
There are no direct flights from Detroit to Santiago. There are no popular flight routes from Detroit to Santiago.
Search flight deals

  • How far is Detroit to Santiago Arturo Merino Benitez by plane?

    The distance between Detroit and Santiago Arturo Merino Benitez is about 5291.2 mi. In terms of flight time, this usually takes a little over 14h 12m.

  • When did momondo last update prices for flights from Detroit to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Santiago?

Best airlines flying from Detroit to Santiago

Compare and see reviews for airlines that fly from Detroit to Santiago with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $733Free CancellationRating
7.5
1,904 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $808Free CancellationRating
7.2
11,132 reviews
Search American Airlines flights
DeltaPriceFrom $873Free CancellationRating
7.9
8,049 reviews
Search Delta flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago?

It is quick and easy to find Detroit to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Detroit to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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