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Cheap flights from Detroit to Santiago from $621

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago departing on 3/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:20 am - 6:40 am
DTW
-
SCL
24h 20m
2 stops
Multiple Airlines Logo
11:24 am - 5:10 pm
SCL
-
DTW
30h 46m
3 stops
$621Multiple Airlines
Fri, Mar 20 - Fri, Mar 27
Multiple Airlines Logo
6:05 am - 10:39 am
DTW
-
SCL
27h 34m
3 stops
Multiple Airlines Logo
11:24 am - 3:50 pm
SCL
-
DTW
29h 26m
3 stops
$629Multiple Airlines
Thu, Mar 19 - Thu, Mar 26
Multiple Airlines Logo
5:45 am - 5:14 am
DTW
-
SCL
22h 29m
2 stops
Multiple Airlines Logo
11:24 am - 3:50 pm
SCL
-
DTW
29h 26m
3 stops
$632Multiple Airlines
Thu, Mar 19 - Thu, Mar 26
Multiple Airlines Logo
5:45 am - 10:39 am
DTW
-
SCL
27h 54m
2 stops
Multiple Airlines Logo
11:24 am - 3:12 pm
SCL
-
DTW
28h 48m
2 stops
$636Multiple Airlines
Thu, Mar 19 - Thu, Mar 26
Multiple Airlines Logo
4:09 pm - 10:39 am
DTW
-
SCL
41h 30m
2 stops
Multiple Airlines Logo
10:35 am - 11:59 pm
SCL
-
DTW
14h 24m
1 stop
$655Multiple Airlines
Thu, Mar 19 - Thu, Mar 26
Multiple Airlines Logo
5:20 am - 6:40 am
DTW
-
SCL
24h 20m
2 stops
Multiple Airlines Logo
10:35 am - 11:01 am
SCL
-
DTW
25h 26m
1 stop
$656Multiple Airlines
Fri, Mar 20 - Fri, Mar 27
Multiple Airlines Logo
8:00 am - 4:45 am
DTW
-
SCL
20h 45m
2 stops
Multiple Airlines Logo
12:30 am - 9:34 pm
SCL
-
DTW
21h 04m
2 stops
$673Multiple Airlines
Tue, May 5 - Wed, May 27
Multiple Airlines Logo
3:59 pm - 5:14 am
DTW
-
SCL
36h 15m
2 stops
Multiple Airlines Logo
10:30 am - 11:59 pm
SCL
-
DTW
14h 29m
1 stop
$736Multiple Airlines
Tue, Mar 10 - Tue, Mar 31
Multiple Airlines Logo
5:00 am - 3:56 am
DTW
-
SCL
22h 56m
2 stops
Multiple Airlines Logo
6:40 am - 12:56 pm
SCL
-
DTW
30h 16m
3 stops
$753Multiple Airlines
Tue, May 12 - Thu, May 21
Multiple Airlines Logo
4:48 pm - 4:16 am
DTW
-
SCL
35h 28m
3 stops
Multiple Airlines Logo
6:40 am - 12:56 pm
SCL
-
DTW
30h 16m
3 stops
$776Multiple Airlines
Tue, May 12 - Thu, May 21

American Airlines flights from Detroit to Santiago

Our best American Airlines deals on Detroit to Santiago flight tickets
American Airlines
Mar 10
DTW11:03 amDetroit Metropolitan Wayne County
21h 02m
2 stops
SCL9:05 amSantiago Arturo Merino Benitez
Mar 31
SCL9:25 pmSantiago Arturo Merino Benitez
18h 32m
2 stops
DTW2:57 pmDetroit Metropolitan Wayne County
$863
American Airlines
May 10
DTW11:55 amDetroit Metropolitan Wayne County
19h 10m
2 stops
SCL7:05 amSantiago Arturo Merino Benitez
May 20
SCL8:35 pmSantiago Arturo Merino Benitez
18h 53m
2 stops
DTW3:28 pmDetroit Metropolitan Wayne County
$903
American Airlines
May 5
DTW6:07 amDetroit Metropolitan Wayne County
24h 58m
1 stop
SCL7:05 amSantiago Arturo Merino Benitez
May 28
SCL8:30 pmSantiago Arturo Merino Benitez
19h 04m
2 stops
DTW3:34 pmDetroit Metropolitan Wayne County
$908

LATAM Airlines flights from Detroit to Santiago

Our best LATAM Airlines deals on Detroit to Santiago flight tickets
LATAM Airlines
May 11
DTW6:27 pmDetroit Metropolitan Wayne County
12h 48m
1 stop
SCL7:15 amSantiago Arturo Merino Benitez
May 20
SCL7:45 pmSantiago Arturo Merino Benitez
19h 21m
2 stops
DTW3:06 pmDetroit Metropolitan Wayne County
$1,038
LATAM Airlines
May 5
DTW4:46 pmDetroit Metropolitan Wayne County
14h 04m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
May 28
SCL11:00 pmSantiago Arturo Merino Benitez
16h 52m
1 stop
DTW3:52 pmDetroit Metropolitan Wayne County
$1,046

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 3/20

5:20 am-6:40 am

2 stops24h 20m

Santiago Arturo Merino Benitez

Fri 3/27

11:24 am-5:10 pm

3 stops30h 46m

$621

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 3/19

6:05 am-10:39 am

3 stops27h 34m

Santiago Arturo Merino Benitez

Thu 3/26

11:24 am-3:50 pm

3 stops29h 26m

$629

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 3/19

5:45 am-5:14 am

2 stops22h 29m

Santiago Arturo Merino Benitez

Thu 3/26

11:24 am-3:50 pm

3 stops29h 26m

$632

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 3/19

5:45 am-10:39 am

2 stops27h 54m

Santiago Arturo Merino Benitez

Thu 3/26

11:24 am-3:12 pm

2 stops28h 48m

$636

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Thu 3/19

4:09 pm-10:39 am

2 stops41h 30m

Santiago Arturo Merino Benitez

Thu 3/26

10:35 am-11:59 pm

1 stop14h 24m

$655

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 3/20

5:20 am-6:40 am

2 stops24h 20m

Santiago Arturo Merino Benitez

Fri 3/27

10:35 am-11:01 am

1 stop25h 26m

$656

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 5/5

8:00 am-4:45 am

2 stops20h 45m

Santiago Arturo Merino Benitez

Wed 5/27

12:30 am-9:34 pm

2 stops21h 04m

$673

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 3/10

3:59 pm-5:14 am

2 stops36h 15m

Santiago Arturo Merino Benitez

Tue 3/31

10:30 am-11:59 pm

1 stop14h 29m

$736

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 5/12

5:00 am-3:56 am

2 stops22h 56m

Santiago Arturo Merino Benitez

Thu 5/21

6:40 am-12:56 pm

3 stops30h 16m

$753

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 5/12

4:48 pm-4:16 am

3 stops35h 28m

Santiago Arturo Merino Benitez

Thu 5/21

6:40 am-12:56 pm

3 stops30h 16m

$776

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santiago from

How to get the cheapest flight ticket from Detroit to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Santiago?

Can stopping save me money on Detroit to Santiago flights?

You could potentially save up to 23% on your flight if you consider stops on a Detroit to Santiago flight.

When to book flights from Detroit to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago (DTT to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago

Fastest flight time

15h 55m

Direct flights

None
The fastest flight from Detroit to Santiago takes 15h 55m
There are no direct flights from Detroit to Santiago. There are no popular flight routes from Detroit to Santiago.
Search flight deals

  • How far is Detroit to Santiago Arturo Merino Benitez by plane?

    The distance between Detroit and Santiago Arturo Merino Benitez is about 5291.2 mi. In terms of flight time, this usually takes a little over 15h 55m.

  • When did momondo last update prices for flights from Detroit to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Santiago?

Best airlines flying from Detroit to Santiago

Compare and see reviews for airlines that fly from Detroit to Santiago with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $563Free CancellationRating
7.9
8,138 reviews
Search Delta flights
LATAM AirlinesPriceFrom $733Free CancellationRating
7.5
1,918 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago?

It is quick and easy to find Detroit to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Detroit to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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