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Cheap flights from Detroit to Santiago from $328

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago departing on 3/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:05 am - 3:55 am
DTW
-
SCL
22h 50m
3 stops
Multiple Airlines Logo
2:30 pm - 12:56 pm
SCL
-
DTW
22h 26m
3 stops
$686Multiple Airlines
Sun, May 10 - Thu, May 21
Multiple Airlines Logo
5:05 am - 3:55 am
DTW
-
SCL
22h 50m
2 stops
Multiple Airlines Logo
6:10 am - 12:56 pm
SCL
-
DTW
30h 46m
3 stops
$707Multiple Airlines
Sun, May 10 - Thu, May 21
Multiple Airlines Logo
12:22 pm - 12:00 pm
DTW
-
SCL
22h 38m
3 stops
Multiple Airlines Logo
5:50 am - 11:59 pm
SCL
-
DTW
19h 09m
2 stops
$724Multiple Airlines
Fri, Mar 13 - Fri, Mar 20
Multiple Airlines Logo
2:06 pm - 2:40 pm
DTW
-
SCL
47h 34m
3 stops
Multiple Airlines Logo
5:50 am - 11:59 pm
SCL
-
DTW
19h 09m
2 stops
$736Multiple Airlines
Sat, Mar 14 - Sat, Mar 21
Multiple Airlines Logo
12:22 pm - 12:00 pm
DTW
-
SCL
22h 38m
3 stops
Multiple Airlines Logo
10:35 am - 12:06 pm
SCL
-
DTW
26h 31m
1 stop
$740Multiple Airlines
Fri, Mar 13 - Fri, Mar 20
Multiple Airlines Logo
12:22 pm - 12:00 pm
DTW
-
SCL
22h 38m
3 stops
Multiple Airlines Logo
9:05 pm - 8:54 pm
SCL
-
DTW
24h 49m
3 stops
$744Multiple Airlines
Fri, Mar 13 - Fri, Mar 20
Multiple Airlines Logo
5:05 am - 3:55 am
DTW
-
SCL
22h 50m
2 stops
Multiple Airlines Logo
3:20 pm - 5:09 pm
SCL
-
DTW
25h 49m
2 stops
$753Multiple Airlines
Sun, May 10 - Thu, May 21
Multiple Airlines Logo
5:09 am - 2:40 pm
DTW
-
SCL
31h 31m
3 stops
Multiple Airlines Logo
12:35 pm - 9:39 pm
SCL
-
DTW
35h 04m
2 stops
$763Multiple Airlines
Tue, Feb 24 - Tue, Mar 3
Multiple Airlines Logo
5:15 am - 4:00 am
DTW
-
SCL
20h 45m
2 stops
Multiple Airlines Logo
11:25 pm - 8:31 am
SCL
-
DTW
35h 06m
1 stop
$769Multiple Airlines
Tue, Feb 24 - Tue, Mar 3
Multiple Airlines Logo
5:09 am - 2:40 pm
DTW
-
SCL
31h 31m
3 stops
Multiple Airlines Logo
11:24 am - 3:57 pm
SCL
-
DTW
30h 33m
3 stops
$772Multiple Airlines
Tue, Feb 24 - Tue, Mar 3

American Airlines flights from Detroit to Santiago

Our best American Airlines deals on Detroit to Santiago flight tickets
American Airlines
Feb 24
DTW4:01 pmDetroit Metropolitan Wayne County
14h 04m
1 stop
SCL8:05 amSantiago Arturo Merino Benitez
Mar 3
SCL11:15 pmSantiago Arturo Merino Benitez
17h 54m
1 stop
DTW3:09 pmDetroit Metropolitan Wayne County
$858
American Airlines
Apr 1
DTW6:00 pmDetroit Metropolitan Wayne County
12h 50m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Apr 22
SCL8:30 pmSantiago Arturo Merino Benitez
20h 01m
2 stops
DTW4:31 pmDetroit Metropolitan Wayne County
$863
American Airlines
May 10
DTW11:57 amDetroit Metropolitan Wayne County
18h 58m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
May 20
SCL8:30 pmSantiago Arturo Merino Benitez
19h 04m
2 stops
DTW3:34 pmDetroit Metropolitan Wayne County
$903

United Airlines flights from Detroit to Santiago

Our best United Airlines deals on Detroit to Santiago flight tickets
United Airlines
Mar 23
DTW1:52 pmDetroit Metropolitan Wayne County
16h 58m
2 stops
SCL7:50 amSantiago Arturo Merino Benitez
Mar 25
SCL9:45 pmSantiago Arturo Merino Benitez
23h 25m
2 stops
DTW8:10 pmDetroit Metropolitan Wayne County
$878
United Airlines
Mar 23
DTW10:55 amDetroit Metropolitan Wayne County
19h 55m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Mar 25
SCL9:45 pmSantiago Arturo Merino Benitez
19h 16m
1 stop
DTW4:01 pmDetroit Metropolitan Wayne County
$893
United Airlines
Mar 23
DTW1:52 pmDetroit Metropolitan Wayne County
16h 58m
2 stops
SCL7:50 amSantiago Arturo Merino Benitez
Mar 25
SCL9:45 pmSantiago Arturo Merino Benitez
20h 59m
2 stops
DTW5:44 pmDetroit Metropolitan Wayne County
$898

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sun 5/10

5:05 am-3:55 am

3 stops22h 50m

Santiago Arturo Merino Benitez

Thu 5/21

2:30 pm-12:56 pm

3 stops22h 26m

$686

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sun 5/10

5:05 am-3:55 am

2 stops22h 50m

Santiago Arturo Merino Benitez

Thu 5/21

6:10 am-12:56 pm

3 stops30h 46m

$707

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 3/13

12:22 pm-12:00 pm

3 stops22h 38m

Santiago Arturo Merino Benitez

Fri 3/20

5:50 am-11:59 pm

2 stops19h 09m

$724

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sat 3/14

2:06 pm-2:40 pm

3 stops47h 34m

Santiago Arturo Merino Benitez

Sat 3/21

5:50 am-11:59 pm

2 stops19h 09m

$736

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 3/13

12:22 pm-12:00 pm

3 stops22h 38m

Santiago Arturo Merino Benitez

Fri 3/20

10:35 am-12:06 pm

1 stop26h 31m

$740

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 3/13

12:22 pm-12:00 pm

3 stops22h 38m

Santiago Arturo Merino Benitez

Fri 3/20

9:05 pm-8:54 pm

3 stops24h 49m

$744

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sun 5/10

5:05 am-3:55 am

2 stops22h 50m

Santiago Arturo Merino Benitez

Thu 5/21

3:20 pm-5:09 pm

2 stops25h 49m

$753

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 2/24

5:09 am-2:40 pm

3 stops31h 31m

Santiago Arturo Merino Benitez

Tue 3/3

12:35 pm-9:39 pm

2 stops35h 04m

$763

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 2/24

5:15 am-4:00 am

2 stops20h 45m

Santiago Arturo Merino Benitez

Tue 3/3

11:25 pm-8:31 am

1 stop35h 06m

$769

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 2/24

5:09 am-2:40 pm

3 stops31h 31m

Santiago Arturo Merino Benitez

Tue 3/3

11:24 am-3:57 pm

3 stops30h 33m

$772

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Santiago?

Can stopping save me money on Detroit to Santiago flights?

You could potentially save up to 23% on your flight if you consider stops on a Detroit to Santiago flight.

When to book flights from Detroit to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago (DTT to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago

Fastest flight time

17h 33m

Direct flights

None
The fastest flight from Detroit to Santiago takes 17h 33m
There are no direct flights from Detroit to Santiago. There are no popular flight routes from Detroit to Santiago.
Search flight deals

  • How far is Detroit to Santiago Arturo Merino Benitez by plane?

    The distance between Detroit and Santiago Arturo Merino Benitez is about 5291.2 mi. In terms of flight time, this usually takes a little over 17h 33m.

  • When did momondo last update prices for flights from Detroit to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Santiago?

Best airlines flying from Detroit to Santiago

Compare and see reviews for airlines that fly from Detroit to Santiago with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $563Free CancellationRating
7.9
8,127 reviews
Search Delta flights
LATAM AirlinesPriceFrom $733Free CancellationRating
7.5
1,918 reviews
Search LATAM Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago?

It is quick and easy to find Detroit to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Detroit to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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