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Cheap flights from Detroit to Santiago from $274

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Santiago departing on 11/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:12 pm - 10:15 pmDTW-SCL
29h 03m3 stops
Multiple Airlines Logo
9:05 pm - 5:41 pmSCL-DTW
22h 36m3 stops
$632Multiple Airlines
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mié., nov. 12 - mié., nov. 19
Multiple Airlines Logo
3:12 pm - 10:15 pmDTW-SCL
29h 03m3 stops
Multiple Airlines Logo
5:50 am - 2:29 pmSCL-DTW
34h 39m2 stops
$640Multiple Airlines
Find Deal
mié., nov. 12 - mié., nov. 19
Multiple Airlines Logo
11:55 am - 5:50 amDTW-SCL
39h 55m3 stops
Multiple Airlines Logo
11:24 am - 3:40 pmSCL-DTW
30h 16m3 stops
$658Multiple Airlines
Find Deal
jue., ene. 29 - dom., feb. 8
Multiple Airlines Logo
7:10 am - 10:15 pmDTW-SCL
37h 05m2 stops
Multiple Airlines Logo
11:25 pm - 2:29 pmSCL-DTW
17h 04m1 stop
$690Multiple Airlines
Find Deal
mié., nov. 12 - mié., nov. 19
United Airlines Logo
8:15 am - 8:50 amDTW-SCL
22h 35m1 stop
United Airlines Logo
10:45 pm - 1:39 pmSCL-DTW
16h 54m1 stop
$864United Airlines
Find Deal
mié., nov. 12 - mié., nov. 19
United Airlines Logo
2:15 pm - 7:50 amDTW-SCL
40h 35m2 stops
United Airlines Logo
9:45 pm - 10:00 pmSCL-DTW
25h 15m2 stops
$885United Airlines
Find Deal
dom., mar. 8 - jue., mar. 19
American Airlines Logo
6:00 am - 7:45 amDTW-SCL
23h 45m1 stop
American Airlines Logo
11:15 pm - 6:39 pmSCL-DTW
21h 24m1 stop
$904American Airlines
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lun., dic. 8 - dom., dic. 14
American Airlines Logo
1:08 pm - 9:05 amDTW-SCL
17h 57m2 stops
American Airlines Logo
10:15 pm - 4:17 pmSCL-DTW
20h 02m2 stops
$909American Airlines
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jue., feb. 5 - dom., feb. 15
United Airlines Logo
4:30 pm - 8:50 amDTW-SCL
14h 20m1 stop
United Airlines Logo
10:45 pm - 8:58 pmSCL-DTW
24h 13m2 stops
$919United Airlines
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mar., dic. 23 - mar., dic. 30
American Airlines Logo
6:17 am - 7:05 amDTW-SCL
24h 48m1 stop
American Airlines Logo
8:50 pm - 3:20 pmSCL-DTW
18h 30m2 stops
$920American Airlines
Find Deal
mar., abr. 7 - mar., abr. 14

American Airlines flights from Detroit to Santiago

Our best American Airlines deals on Detroit to Santiago flight tickets
American Airlines
Oct 22
DTW3:59 pmDetroit Metropolitan Wayne County
15h 01m
2 stops
SCL8:00 amSantiago Arturo Merino Benitez
Nov 12
SCL10:25 pmSantiago Arturo Merino Benitez
20h 16m
2 stops
DTW4:41 pmDetroit Metropolitan Wayne County
$869
Find similar
American Airlines
Oct 22
DTW6:00 amDetroit Metropolitan Wayne County
25h 00m
1 stop
SCL8:00 amSantiago Arturo Merino Benitez
Nov 11
SCL11:15 pmSantiago Arturo Merino Benitez
17h 47m
1 stop
DTW3:02 pmDetroit Metropolitan Wayne County
$876
Find similar
American Airlines
Oct 22
DTW4:58 pmDetroit Metropolitan Wayne County
14h 02m
2 stops
SCL8:00 amSantiago Arturo Merino Benitez
Nov 12
SCL10:25 pmSantiago Arturo Merino Benitez
27h 26m
1 stop
DTW11:51 pmDetroit Metropolitan Wayne County
$880
Find similar

United Airlines flights from Detroit to Santiago

Our best United Airlines deals on Detroit to Santiago flight tickets
United Airlines
Nov 12
DTW8:15 amDetroit Metropolitan Wayne County
22h 35m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Nov 19
SCL10:45 pmSantiago Arturo Merino Benitez
16h 54m
1 stop
DTW1:39 pmDetroit Metropolitan Wayne County
$864
Find similar
United Airlines
Mar 8
DTW2:15 pmDetroit Metropolitan Wayne County
40h 35m
2 stops
SCL7:50 amSantiago Arturo Merino Benitez
Mar 19
SCL9:45 pmSantiago Arturo Merino Benitez
25h 15m
2 stops
DTW10:00 pmDetroit Metropolitan Wayne County
$885
Find similar
United Airlines
Dec 23
DTW4:30 pmDetroit Metropolitan Wayne County
14h 20m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Dec 30
SCL10:45 pmSantiago Arturo Merino Benitez
24h 13m
2 stops
DTW8:58 pmDetroit Metropolitan Wayne County
$919
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated octubre 16, 2025.
Use the filters below to find and compare flights from Detroit to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

mié. 11/12

3:12 pm-10:15 pm

3 stops29h 03m

Santiago Arturo Merino Benitez

mié. 11/19

9:05 pm-5:41 pm

3 stops22h 36m

$632

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

mié. 11/12

3:12 pm-10:15 pm

3 stops29h 03m

Santiago Arturo Merino Benitez

mié. 11/19

5:50 am-2:29 pm

2 stops34h 39m

$640

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

jue. 1/29

11:55 am-5:50 am

3 stops39h 55m

Santiago Arturo Merino Benitez

dom. 2/8

11:24 am-3:40 pm

3 stops30h 16m

$658

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

mié. 11/12

7:10 am-10:15 pm

2 stops37h 05m

Santiago Arturo Merino Benitez

mié. 11/19

11:25 pm-2:29 pm

1 stop17h 04m

$690

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

mié. 11/12

8:15 am-8:50 am

1 stop22h 35m

Santiago Arturo Merino Benitez

mié. 11/19

10:45 pm-1:39 pm

1 stop16h 54m

$864

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

dom. 3/8

2:15 pm-7:50 am

2 stops40h 35m

Santiago Arturo Merino Benitez

jue. 3/19

9:45 pm-10:00 pm

2 stops25h 15m

$885

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

lun. 12/8

6:00 am-7:45 am

1 stop23h 45m

Santiago Arturo Merino Benitez

dom. 12/14

11:15 pm-6:39 pm

1 stop21h 24m

$904

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

jue. 2/5

1:08 pm-9:05 am

2 stops17h 57m

Santiago Arturo Merino Benitez

dom. 2/15

10:15 pm-4:17 pm

2 stops20h 02m

$909

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

mar. 12/23

4:30 pm-8:50 am

1 stop14h 20m

Santiago Arturo Merino Benitez

mar. 12/30

10:45 pm-8:58 pm

2 stops24h 13m

$919

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

mar. 4/7

6:17 am-7:05 am

1 stop24h 48m

Santiago Arturo Merino Benitez

mar. 4/14

8:50 pm-3:20 pm

2 stops18h 30m

$920

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Santiago?

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Saturday when prices can be found for as low as $932. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Sunday is $1,272.

What is the cheapest time of day to depart on your flight to Santiago?

In the evening is the cheapest time of day to fly from Detroit to Santiago when you can find flight prices for as low as $937. Flying to Santiago in the evening is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Santiago, so prices are often more expensive at around $1,126 per ticket.

Can stopping save me money on Detroit to Santiago flights?

You could potentially save up to 3% on your flight if you consider stops on a Detroit to Santiago flight.

When to book flights from Detroit to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Santiago (DTT to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Santiago

Direct flights

None
There are no direct flights from Detroit to Santiago. There are no popular flight routes from Detroit to Santiago.
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  • How far is Detroit to Santiago Arturo Merino Benitez by plane?

    The distance between Detroit and Santiago Arturo Merino Benitez is about 5291.2 mi. In terms of flight time, this usually takes a little over 14h 20m.

  • When did momondo last update prices for flights from Detroit to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Detroit to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Detroit to Santiago Arturo Merino Benitez Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Santiago?

Best airlines flying from Detroit to Santiago

Compare and see reviews for airlines that fly from Detroit to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Air CanadaPriceFrom $684Free CancellationRating
7.1
10,307 reviews
Search Air Canada flights
LATAM AirlinesPriceFrom $733Free CancellationRating
7.5
1,866 reviews
Search LATAM Airlines flights
DeltaPriceFrom $768Free CancellationRating
7.9
7,982 reviews
Search Delta flights
American AirlinesPriceFrom $822Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Santiago?

It is quick and easy to find Detroit to Santiago flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santiago that suits you.

Can I find flights from Detroit to Santiago with flexible booking policies on momondo?

Flights from Detroit to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Detroit. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Detroit to Santiago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Detroit to Santiago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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