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Cheap flights from Detroit to Panama City from $290

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Panama City departing on 12/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Multiple Airlines Logo
7:05 am - 1:00 amDTW-PTY
18h 55m2 stops
Multiple Airlines Logo
2:55 am - 6:54 pmPTY-DTW
15h 59m2 stops
$386Multiple Airlines
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Thu, Oct 30 - Wed, Nov 5
Multiple Airlines Logo
8:00 am - 12:40 amDTW-PTY
16h 40m2 stops
Multiple Airlines Logo
2:55 pm - 2:09 pmPTY-DTW
23h 14m2 stops
$435Multiple Airlines
Find Deal
Wed, Feb 4 - Tue, Feb 10
Multiple Airlines Logo
6:17 am - 12:10 amDTW-PTY
18h 53m2 stops
Multiple Airlines Logo
2:55 am - 8:00 pmPTY-DTW
16h 05m2 stops
$450Multiple Airlines
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Thu, Oct 23 - Sun, Oct 26
Multiple Airlines Logo
7:05 am - 1:00 amDTW-PTY
18h 55m2 stops
Multiple Airlines Logo
2:55 pm - 2:09 pmPTY-DTW
23h 14m2 stops
$476Multiple Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6
United Airlines Logo
8:15 am - 7:38 pmDTW-PTY
11h 23m1 stop
United Airlines Logo
9:30 am - 7:38 pmPTY-DTW
9h 08m1 stop
$598United Airlines
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Thu, Mar 5 - Wed, Mar 18
United Airlines Logo
6:00 am - 7:02 pmDTW-PTY
14h 02m2 stops
United Airlines Logo
10:55 pm - 1:16 pmPTY-DTW
13h 21m2 stops
$603United Airlines
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Mon, Mar 9 - Wed, Mar 18
American Airlines Logo
5:59 am - 1:10 pmDTW-PTY
7h 11m1 stop
American Airlines Logo
2:45 pm - 10:43 pmPTY-DTW
7h 58m1 stop
$618American Airlines
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Wed, Jan 14 - Sat, Jan 31
Delta Logo
12:15 pm - 8:04 pmDTW-PTY
7h 49m1 stop
Delta Logo
2:20 pm - 9:27 amPTY-DTW
18h 07m1 stop
$623Delta
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Sat, Mar 7 - Thu, Mar 19
American Airlines Logo
6:37 pm - 12:10 pmDTW-PTY
17h 33m2 stops
American Airlines Logo
1:50 pm - 11:19 amPTY-DTW
20h 29m2 stops
$643American Airlines
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Sat, Mar 7 - Sat, Mar 14
Delta Logo
7:45 pm - 12:55 pmDTW-PTY
18h 10m1 stop
Delta Logo
2:20 pm - 9:27 amPTY-DTW
18h 07m1 stop
$661Delta
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Sun, Mar 8 - Mon, Mar 16

American Airlines flights from Detroit to Panama City

Our best American Airlines deals on Detroit to Panama City flight tickets
American Airlines
Jan 14
DTW5:59 amDetroit Metropolitan Wayne County
7h 11m
1 stop
PTY1:10 pmPanama City Tocumen Intl
Jan 31
PTY2:45 pmPanama City Tocumen Intl
7h 58m
1 stop
DTW10:43 pmDetroit Metropolitan Wayne County
$618
Find similar
American Airlines
Mar 7
DTW6:37 pmDetroit Metropolitan Wayne County
17h 33m
2 stops
PTY12:10 pmPanama City Tocumen Intl
Mar 14
PTY1:50 pmPanama City Tocumen Intl
20h 29m
2 stops
DTW11:19 amDetroit Metropolitan Wayne County
$643
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American Airlines
Sep 18
DTW5:43 amDetroit Metropolitan Wayne County
9h 48m
2 stops
PTY2:31 pmPanama City Tocumen Intl
Sep 23
PTY1:45 pmPanama City Tocumen Intl
18h 30m
2 stops
DTW9:15 amDetroit Metropolitan Wayne County
$1,263
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Copa Airlines flights from Detroit to Panama City

Our best Copa Airlines deals on Detroit to Panama City flight tickets
Copa Airlines
Sep 18
DTW6:00 amDetroit Metropolitan Wayne County
8h 31m
1 stop
PTY1:31 pmPanama City Tocumen Intl
Sep 23
PTY10:29 pmPanama City Tocumen Intl
10h 28m
1 stop
DTW9:57 amDetroit Metropolitan Wayne County
$1,157
Find similar
Copa Airlines
Sep 19
DTW6:00 amDetroit Metropolitan Wayne County
15h 34m
1 stop
PTY8:34 pmPanama City Tocumen Intl
Sep 21
PTY10:29 pmPanama City Tocumen Intl
10h 28m
1 stop
DTW9:57 amDetroit Metropolitan Wayne County
$1,295
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momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Detroit to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 10/30

7:05 am-1:00 am

2 stops18h 55m

Panama City Tocumen Intl

Wed 11/5

2:55 am-6:54 pm

2 stops15h 59m

$386

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 2/4

8:00 am-12:40 am

2 stops16h 40m

Panama City Tocumen Intl

Tue 2/10

2:55 pm-2:09 pm

2 stops23h 14m

$435

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 10/23

6:17 am-12:10 am

2 stops18h 53m

Panama City Tocumen Intl

Sun 10/26

2:55 am-8:00 pm

2 stops16h 05m

$450

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 10/30

7:05 am-1:00 am

2 stops18h 55m

Panama City Tocumen Intl

Thu 11/6

2:55 pm-2:09 pm

2 stops23h 14m

$476

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 3/5

8:15 am-7:38 pm

1 stop11h 23m

Panama City Tocumen Intl

Wed 3/18

9:30 am-7:38 pm

1 stop9h 08m

$598

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 3/9

6:00 am-7:02 pm

2 stops14h 02m

Panama City Tocumen Intl

Wed 3/18

10:55 pm-1:16 pm

2 stops13h 21m

$603

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Wed 1/14

5:59 am-1:10 pm

1 stop7h 11m

Panama City Tocumen Intl

Sat 1/31

2:45 pm-10:43 pm

1 stop7h 58m

$618

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 3/7

12:15 pm-8:04 pm

1 stop7h 49m

Panama City Tocumen Intl

Thu 3/19

2:20 pm-9:27 am

1 stop18h 07m

$623

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sat 3/7

6:37 pm-12:10 pm

2 stops17h 33m

Panama City Tocumen Intl

Sat 3/14

1:50 pm-11:19 am

2 stops20h 29m

$643

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Sun 3/8

7:45 pm-12:55 pm

1 stop18h 10m

Panama City Tocumen Intl

Mon 3/16

2:20 pm-9:27 am

1 stop18h 07m

$661

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Detroit to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, August is the cheapest month to fly from Detroit to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $608. If you’re not able to fly to Panama City in August, then July is your next best option. Flight prices from Detroit to Panama City during July average around $631.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $745. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $861. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from Detroit to Panama City during this time can be as low as $786. Try not to purchase tickets in the afternoon because they tend to be around $923. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $895 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Detroit for as low as $622 on momondo.

When to book flights from Detroit to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Panama City (DTT to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Panama City

Direct flights

None
There are no direct flights from Detroit to Panama City. There are no popular flight routes from Detroit to Panama City.
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  • How far is Detroit to Panama City Tocumen Intl by plane?

    Detroit and Panama City Tocumen Intl are 2312.9 mi apart from one another. Flights usually cover this in 7h 11m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit to Panama City Tocumen Intl Airport?

    Prices for flights from Detroit to Panama City Tocumen Intl Airport are updated daily.

  • How many operators does momondo search for flights from Detroit to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Detroit to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Detroit to Panama City?

Best airlines flying from Detroit to Panama City

Compare and see reviews for airlines that fly from Detroit to Panama City with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $578Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $608Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
DeltaPriceFrom $608Free CancellationRating
7.9
7,961 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama City?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama City from Detroit.

Can I find flights from Detroit to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Panama City?

momondo helps you find the best flight between Detroit and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Detroit and alert you when they change.

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