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Cheap flights from Detroit to Panama City from $210

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Panama City departing on 4/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:24 am - 10:30 am
DTW
-
PTY
25h 06m
3 stops
Multiple Airlines Logo
3:05 am - 6:44 pm
PTY
-
DTW
14h 39m
2 stops
$476Multiple Airlines
Thu, Apr 9 - Wed, Apr 15
Multiple Airlines Logo
4:50 pm - 2:00 pm
DTW
-
PTY
22h 10m
2 stops
Multiple Airlines Logo
2:55 am - 12:20 pm
PTY
-
DTW
32h 25m
2 stops
$482Multiple Airlines
Tue, Mar 17 - Tue, Mar 24
Multiple Airlines Logo
6:05 am - 2:00 pm
DTW
-
PTY
32h 55m
3 stops
Multiple Airlines Logo
9:45 am - 12:20 pm
PTY
-
DTW
25h 35m
2 stops
$484Multiple Airlines
Tue, Mar 17 - Wed, Mar 25
Multiple Airlines Logo
7:15 am - 8:19 pm
DTW
-
PTY
14h 04m
1 stop
Multiple Airlines Logo
12:03 pm - 12:46 am
PTY
-
DTW
11h 43m
1 stop
$493Multiple Airlines
Thu, Apr 9 - Thu, Apr 16
Multiple Airlines Logo
11:34 am - 8:50 am
DTW
-
PTY
22h 16m
3 stops
Multiple Airlines Logo
2:55 pm - 12:20 pm
PTY
-
DTW
20h 25m
2 stops
$494Multiple Airlines
Mon, Mar 16 - Wed, Mar 18
Multiple Airlines Logo
11:34 am - 8:50 am
DTW
-
PTY
22h 16m
3 stops
Multiple Airlines Logo
5:50 pm - 10:37 pm
PTY
-
DTW
27h 47m
3 stops
$505Multiple Airlines
Mon, Mar 16 - Wed, Mar 18
Multiple Airlines Logo
5:20 am - 7:20 pm
DTW
-
PTY
15h 00m
1 stop
Multiple Airlines Logo
10:25 am - 11:59 pm
PTY
-
DTW
12h 34m
1 stop
$509Multiple Airlines
Mon, Mar 16 - Tue, Mar 17
Multiple Airlines Logo
4:50 pm - 8:50 am
DTW
-
PTY
17h 00m
2 stops
Multiple Airlines Logo
2:55 pm - 12:20 pm
PTY
-
DTW
20h 25m
2 stops
$510Multiple Airlines
Mon, Mar 16 - Wed, Mar 18
Multiple Airlines Logo
10:24 am - 8:35 pm
DTW
-
PTY
11h 11m
1 stop
Multiple Airlines Logo
9:33 pm - 11:38 am
PTY
-
DTW
13h 05m
2 stops
$511Multiple Airlines
Thu, Apr 9 - Thu, Apr 16
Multiple Airlines Logo
10:24 am - 7:20 pm
DTW
-
PTY
9h 56m
1 stop
Multiple Airlines Logo
9:33 pm - 11:38 am
PTY
-
DTW
13h 05m
2 stops
$514Multiple Airlines
Thu, Apr 9 - Thu, Apr 16

Copa Airlines flights from Detroit to Panama City

Our best Copa Airlines deals on Detroit to Panama City flight tickets
Copa Airlines
Mar 11
DTW5:48 amDetroit Metropolitan Wayne County
9h 12m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Mar 21
PTY9:11 amPanama City Tocumen Intl
8h 44m
1 stop
DTW6:55 pmDetroit Metropolitan Wayne County
$861
Copa Airlines
Mar 11
DTW5:48 amDetroit Metropolitan Wayne County
9h 12m
1 stop
PTY2:00 pmPanama City Tocumen Intl
Mar 21
PTY9:11 amPanama City Tocumen Intl
8h 44m
1 stop
DTW6:55 pmDetroit Metropolitan Wayne County
$908
Copa Airlines
Mar 3
DTW10:28 amDetroit Metropolitan Wayne County
10h 07m
1 stop
PTY8:35 pmPanama City Tocumen Intl
Apr 4
PTY9:13 amPanama City Tocumen Intl
8h 38m
1 stop
DTW6:51 pmDetroit Metropolitan Wayne County
$975

United Airlines flights from Detroit to Panama City

Our best United Airlines deals on Detroit to Panama City flight tickets
United Airlines
Mar 12
DTW6:15 amDetroit Metropolitan Wayne County
13h 23m
1 stop
PTY6:38 pmPanama City Tocumen Intl
Mar 19
PTY3:41 pmPanama City Tocumen Intl
20h 30m
2 stops
DTW1:11 pmDetroit Metropolitan Wayne County
$954
United Airlines
Mar 12
DTW6:15 amDetroit Metropolitan Wayne County
10h 52m
1 stop
PTY4:07 pmPanama City Tocumen Intl
Mar 20
PTY10:55 pmPanama City Tocumen Intl
17h 18m
2 stops
DTW5:13 pmDetroit Metropolitan Wayne County
$1,017
United Airlines
Mar 12
DTW6:15 amDetroit Metropolitan Wayne County
10h 52m
1 stop
PTY4:07 pmPanama City Tocumen Intl
Mar 16
PTY3:41 pmPanama City Tocumen Intl
20h 30m
2 stops
DTW1:11 pmDetroit Metropolitan Wayne County
$1,039

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Detroit to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 4/9

10:24 am-10:30 am

3 stops25h 06m

Panama City Tocumen Intl

Wed 4/15

3:05 am-6:44 pm

2 stops14h 39m

$476

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 3/17

4:50 pm-2:00 pm

2 stops22h 10m

Panama City Tocumen Intl

Tue 3/24

2:55 am-12:20 pm

2 stops32h 25m

$482

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Tue 3/17

6:05 am-2:00 pm

3 stops32h 55m

Panama City Tocumen Intl

Wed 3/25

9:45 am-12:20 pm

2 stops25h 35m

$484

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 4/9

7:15 am-8:19 pm

1 stop14h 04m

Panama City Tocumen Intl

Thu 4/16

12:03 pm-12:46 am

1 stop11h 43m

$493

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 3/16

11:34 am-8:50 am

3 stops22h 16m

Panama City Tocumen Intl

Wed 3/18

2:55 pm-12:20 pm

2 stops20h 25m

$494

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 3/16

11:34 am-8:50 am

3 stops22h 16m

Panama City Tocumen Intl

Wed 3/18

5:50 pm-10:37 pm

3 stops27h 47m

$505

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 3/16

5:20 am-7:20 pm

1 stop15h 00m

Panama City Tocumen Intl

Tue 3/17

10:25 am-11:59 pm

1 stop12h 34m

$509

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Mon 3/16

4:50 pm-8:50 am

2 stops17h 00m

Panama City Tocumen Intl

Wed 3/18

2:55 pm-12:20 pm

2 stops20h 25m

$510

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 4/9

10:24 am-8:35 pm

1 stop11h 11m

Panama City Tocumen Intl

Thu 4/16

9:33 pm-11:38 am

2 stops13h 05m

$511

DetroitPanama City

DTW - PTY

DTWPTY

Detroit Metropolitan Wayne County

Thu 4/9

10:24 am-7:20 pm

1 stop9h 56m

Panama City Tocumen Intl

Thu 4/16

9:33 pm-11:38 am

2 stops13h 05m

$514

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Detroit to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Panama City?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama City from Detroit according to our data. American Airlines is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 4 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

When to book flights from Detroit to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Panama City (DTT to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Panama City

Fastest flight time

8h 31m

Direct flights

None
The fastest flight from Detroit to Panama City takes 8h 31m
There are no direct flights from Detroit to Panama City. There are no popular flight routes from Detroit to Panama City.
Search flight deals

  • How far is Detroit to Panama City Tocumen Intl by plane?

    Detroit and Panama City Tocumen Intl are 2312.9 mi apart from one another. Flights usually cover this in 8h 31m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Detroit to Panama City Tocumen Intl Airport?

    Prices for flights from Detroit to Panama City Tocumen Intl Airport are updated daily.

  • How many operators does momondo search for flights from Detroit to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Detroit to Panama City Tocumen Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Detroit to Panama City

Compare and see reviews for airlines that fly from Detroit to Panama City with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $578Free CancellationRating
7.2
11,352 reviews
Search American Airlines flights
DeltaPriceFrom $608Free CancellationRating
7.9
8,237 reviews
Search Delta flights
Copa AirlinesPriceFrom $623Free CancellationRating
7.5
1,557 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $629Free CancellationRating
7.4
9,348 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Panama City?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Panama City from Detroit.

Can I find flights from Detroit to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Panama City?

momondo helps you find the best flight between Detroit and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Detroit to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Detroit and alert you when they change.

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