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Cheap flights from Des Moines to Brussels from $369

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Brussels departing on 5/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Brussels

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
3:17 pm - 1:15 pmDSM-BRU
14h 58m2 stops
United Airlines Logo
10:10 am - 10:53 amBRU-DSM
31h 43m1 stop
$492United Airlines
Find Deal
Mon, Dec 8 - Mon, Dec 15
United Airlines Logo
11:35 am - 8:55 amDSM-BRU
14h 20m1 stop
United Airlines Logo
10:10 am - 9:37 pmBRU-DSM
18h 27m1 stop
$496United Airlines
Find Deal
Mon, Dec 8 - Mon, Dec 15
Delta Logo
5:45 am - 8:00 amDSM-BRU
20h 15m1 stop
Delta Logo
10:45 am - 10:28 pmBRU-DSM
18h 43m1 stop
$656Delta
Find Deal
Fri, Mar 27 - Tue, Mar 31
United Airlines Logo
5:45 am - 1:15 pmDSM-BRU
24h 30m2 stops
United Airlines Logo
2:25 pm - 6:05 pmBRU-DSM
34h 40m2 stops
$658United Airlines
Find Deal
Sat, Dec 13 - Mon, Dec 29
Delta Logo
7:00 am - 8:00 amDSM-BRU
19h 00m2 stops
Delta Logo
10:45 am - 8:53 pmBRU-DSM
17h 08m2 stops
$661Delta
Find Deal
Fri, Mar 27 - Tue, Mar 31
Multiple Airlines Logo
8:00 am - 7:50 amDSM-BRU
16h 50m3 stops
Multiple Airlines Logo
10:00 am - 10:53 amBRU-DSM
31h 53m2 stops
$689Multiple Airlines
Find Deal
Mon, Dec 8 - Mon, Dec 15
United Airlines Logo
11:35 am - 1:15 pmDSM-BRU
18h 40m2 stops
United Airlines Logo
4:55 pm - 8:30 pmBRU-DSM
34h 35m2 stops
$741United Airlines
Find Deal
Mon, Dec 15 - Mon, Dec 22
Multiple Airlines Logo
3:17 pm - 1:15 pmDSM-BRU
14h 58m2 stops
Multiple Airlines Logo
10:30 am - 7:29 pmBRU-DSM
15h 59m2 stops
$804Multiple Airlines
Find Deal
Wed, Dec 17 - Wed, Dec 24
Lufthansa Logo
3:17 pm - 8:55 amDSM-BRU
10h 38m1 stop
Lufthansa Logo
7:00 am - 9:40 pmBRU-DSM
21h 40m2 stops
$883Lufthansa
Find Deal
Wed, Dec 17 - Wed, Dec 24
Lufthansa Logo
11:35 am - 8:55 amDSM-BRU
14h 20m1 stop
Lufthansa Logo
10:10 am - 9:40 pmBRU-DSM
18h 30m1 stop
$1,203Lufthansa
Find Deal
Wed, Dec 17 - Wed, Dec 24

Lufthansa flights from Des Moines to Brussels Bruxelles-National Airport

Our best Lufthansa deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
Lufthansa
Dec 17
DSM3:17 pmDes Moines
10h 38m
1 stop
BRU8:55 amBrussels Bruxelles-National
Dec 24
BRU7:00 amBrussels Bruxelles-National
21h 40m
2 stops
DSM9:40 pmDes Moines
$883
Find similar
Lufthansa
Dec 17
DSM11:35 amDes Moines
14h 20m
1 stop
BRU8:55 amBrussels Bruxelles-National
Dec 24
BRU10:10 amBrussels Bruxelles-National
18h 30m
1 stop
DSM9:40 pmDes Moines
$1,203
Find similar
Lufthansa
Dec 18
DSM11:35 amDes Moines
14h 20m
1 stop
BRU8:55 amBrussels Bruxelles-National
Dec 25
BRU10:10 amBrussels Bruxelles-National
18h 30m
1 stop
DSM9:40 pmDes Moines
$1,410
Find similar

United Airlines flights from Des Moines to Brussels Bruxelles-National Airport

Our best United Airlines deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
United Airlines
Dec 8
DSM3:17 pmDes Moines
14h 58m
2 stops
BRU1:15 pmBrussels Bruxelles-National
Dec 15
BRU10:10 amBrussels Bruxelles-National
31h 43m
1 stop
DSM10:53 amDes Moines
$492
Find similar
United Airlines
Dec 8
DSM11:35 amDes Moines
14h 20m
1 stop
BRU8:55 amBrussels Bruxelles-National
Dec 15
BRU10:10 amBrussels Bruxelles-National
18h 27m
1 stop
DSM9:37 pmDes Moines
$496
Find similar
United Airlines
Dec 13
DSM5:45 amDes Moines
24h 30m
2 stops
BRU1:15 pmBrussels Bruxelles-National
Dec 29
BRU2:25 pmBrussels Bruxelles-National
34h 40m
2 stops
DSM6:05 pmDes Moines
$658
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Des Moines to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 12/8

3:17 pm-1:15 pm

2 stops14h 58m

Brussels Bruxelles-National

Mon 12/15

10:10 am-10:53 am

1 stop31h 43m

$492

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 12/8

11:35 am-8:55 am

1 stop14h 20m

Brussels Bruxelles-National

Mon 12/15

10:10 am-9:37 pm

1 stop18h 27m

$496

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 3/27

5:45 am-8:00 am

1 stop20h 15m

Brussels Bruxelles-National

Tue 3/31

10:45 am-10:28 pm

1 stop18h 43m

$656

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 12/13

5:45 am-1:15 pm

2 stops24h 30m

Brussels Bruxelles-National

Mon 12/29

2:25 pm-6:05 pm

2 stops34h 40m

$658

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 3/27

7:00 am-8:00 am

2 stops19h 00m

Brussels Bruxelles-National

Tue 3/31

10:45 am-8:53 pm

2 stops17h 08m

$661

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 12/8

8:00 am-7:50 am

3 stops16h 50m

Brussels Bruxelles-National

Mon 12/15

10:00 am-10:53 am

2 stops31h 53m

$689

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 12/15

11:35 am-1:15 pm

2 stops18h 40m

Brussels Bruxelles-National

Mon 12/22

4:55 pm-8:30 pm

2 stops34h 35m

$741

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 12/17

3:17 pm-1:15 pm

2 stops14h 58m

Brussels Bruxelles-National

Wed 12/24

10:30 am-7:29 pm

2 stops15h 59m

$804

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 12/17

3:17 pm-8:55 am

1 stop10h 38m

Brussels Bruxelles-National

Wed 12/24

7:00 am-9:40 pm

2 stops21h 40m

$883

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 12/17

11:35 am-8:55 am

1 stop14h 20m

Brussels Bruxelles-National

Wed 12/24

10:10 am-9:40 pm

1 stop18h 30m

$1,203

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Brussels from

How to get the cheapest flight ticket from Des Moines to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Brussels Bruxelles-National Airport?

The cheapest day to depart from Des Moines to Brussels Bruxelles-National Airport is on a Wednesday. Travelers who choose to depart for Brussels Bruxelles-National Airport on a Wednesday will often find tickets for as low as $864. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Brussels Bruxelles-National Airport for around $1,370.

What is the cheapest time of day to depart on your flight to Brussels Bruxelles-National Airport?

Our most recent data shows that the best time of day to fly to Brussels Bruxelles-National Airport is in the morning. Flights from Des Moines to Brussels Bruxelles-National Airport during this time can be as low as $852. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $932 on average. Flights to Brussels Bruxelles-National Airport from Des Moines in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

When to book flights from Des Moines to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Brussels Bruxelles-National Airport (DSM to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Brussels Bruxelles-National Airport

Direct flights

None
There are no direct flights from Des Moines to Brussels Bruxelles-National Airport. There are no popular flight routes from Des Moines to Brussels Bruxelles-National Airport.
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  • How far is Des Moines to Brussels Bruxelles-National by plane?

    There are 4374.0 mi between Des Moines and Brussels Bruxelles-National. Flights usually cover this in 10h 38m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

    Prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from Des Moines Airport to Brussels Bruxelles-National Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The travel and health documents required for your trip to Brussels Bruxelles-National Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Brussels Bruxelles-National Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Brussels Bruxelles-National Airport?

Best airlines flying from Des Moines to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Des Moines to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $794Free CancellationRating
7.4
9,002 reviews
Search United Airlines flights

Traveling to a place near Brussels?

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Ghent
Bruges
Leuven
Charleroi
Hasselt
Spa
Zaventem
Namur
Dinant
Mons
Genk
Waterloo
Durbuy
Mechelen
Francorchamps
Knokke-Heist
Aalst
Tournai
Oostkamp
Halle

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Brussels?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Brussels for you.

Can I find flights from Des Moines to Brussels with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Brussels flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Brussels?

Once you have performed a search for Des Moines to Brussels flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Brussels right now. Can momondo alert me if prices change?

Price alerts on flights to Brussels from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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