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Cheap flights from Des Moines to Brussels from $351

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Brussels departing on 11/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Brussels

Cheap round-trip flights

Enter your travel dates to find the best prices.
Scandinavian Airlines Logo
11:04 am - 7:50 pm
DSM
-
BRU
25h 46m
2 stops
Scandinavian Airlines Logo
3:15 pm - 10:29 pm
BRU
-
DSM
38h 14m
2 stops
$908Scandinavian Airlines
Mon, Oct 5 - Mon, Oct 12
American Airlines Logo
6:07 pm - 8:25 pm
DSM
-
BRU
19h 18m
2 stops
American Airlines Logo
7:05 am - 8:11 pm
BRU
-
DSM
20h 06m
2 stops
$934American Airlines
Tue, Oct 6 - Tue, Oct 13
Scandinavian Airlines Logo
11:04 am - 7:50 pm
DSM
-
BRU
25h 46m
2 stops
Scandinavian Airlines Logo
3:15 pm - 10:29 pm
BRU
-
DSM
38h 14m
2 stops
$942Scandinavian Airlines
Sun, Oct 4 - Mon, Oct 12
United Airlines Logo
11:30 am - 9:00 am
DSM
-
BRU
14h 30m
1 stop
United Airlines Logo
9:25 am - 4:16 pm
BRU
-
DSM
37h 51m
2 stops
$961United Airlines
Tue, Oct 6 - Tue, Oct 13
Air Canada Logo
5:00 am - 7:10 am
DSM
-
BRU
19h 10m
2 stops
Air Canada Logo
9:25 am - 10:20 am
BRU
-
DSM
31h 55m
2 stops
$965Air Canada
Sun, Oct 4 - Wed, Oct 14
Air Canada Logo
6:45 pm - 7:10 am
DSM
-
BRU
29h 25m
2 stops
Air Canada Logo
9:25 am - 10:20 am
BRU
-
DSM
31h 55m
2 stops
$970Air Canada
Sat, Oct 3 - Wed, Oct 14
Scandinavian Airlines Logo
2:15 pm - 2:35 pm
DSM
-
BRU
17h 20m
2 stops
Scandinavian Airlines Logo
10:20 am - 10:29 pm
BRU
-
DSM
19h 09m
2 stops
$977Scandinavian Airlines
Sun, Oct 4 - Tue, Oct 13
United Airlines Logo
3:15 pm - 1:15 pm
DSM
-
BRU
15h 00m
2 stops
United Airlines Logo
10:15 am - 5:33 pm
BRU
-
DSM
14h 18m
1 stop
$978United Airlines
Tue, Oct 6 - Tue, Oct 13
United Airlines Logo
3:15 pm - 9:00 am
DSM
-
BRU
10h 45m
1 stop
United Airlines Logo
10:15 am - 7:25 pm
BRU
-
DSM
16h 10m
1 stop
$981United Airlines
Tue, Oct 6 - Tue, Oct 13
United Airlines Logo
3:15 pm - 1:15 pm
DSM
-
BRU
15h 00m
2 stops
United Airlines Logo
12:00 pm - 11:01 pm
BRU
-
DSM
18h 01m
2 stops
$982United Airlines
Wed, Oct 7 - Fri, Oct 16

United Airlines flights from Des Moines to Brussels Bruxelles-National Airport

Our best United Airlines deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
United Airlines
Oct 6
DSM11:30 amDes Moines
14h 30m
1 stop
BRU9:00 amBrussels Bruxelles-National
Oct 13
BRU9:25 amBrussels Bruxelles-National
37h 51m
2 stops
DSM4:16 pmDes Moines
$961
United Airlines
Oct 6
DSM3:15 pmDes Moines
15h 00m
2 stops
BRU1:15 pmBrussels Bruxelles-National
Oct 13
BRU10:15 amBrussels Bruxelles-National
14h 18m
1 stop
DSM5:33 pmDes Moines
$978
United Airlines
Oct 6
DSM3:15 pmDes Moines
10h 45m
1 stop
BRU9:00 amBrussels Bruxelles-National
Oct 13
BRU10:15 amBrussels Bruxelles-National
16h 10m
1 stop
DSM7:25 pmDes Moines
$981

Air Canada flights from Des Moines to Brussels Bruxelles-National Airport

Our best Air Canada deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
Air Canada
Oct 4
DSM5:00 amDes Moines
19h 10m
2 stops
BRU7:10 amBrussels Bruxelles-National
Oct 14
BRU9:25 amBrussels Bruxelles-National
31h 55m
2 stops
DSM10:20 amDes Moines
$965
Air Canada
Oct 3
DSM6:45 pmDes Moines
29h 25m
2 stops
BRU7:10 amBrussels Bruxelles-National
Oct 14
BRU9:25 amBrussels Bruxelles-National
31h 55m
2 stops
DSM10:20 amDes Moines
$970
Air Canada
Oct 6
DSM8:00 amDes Moines
16h 10m
3 stops
BRU7:10 amBrussels Bruxelles-National
Oct 13
BRU9:25 amBrussels Bruxelles-National
17h 00m
3 stops
DSM7:25 pmDes Moines
$1,005

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 16, 2026.
Use the filters below to find and compare flights from Des Moines to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 10/5

11:04 am-7:50 pm

2 stops25h 46m

Brussels Bruxelles-National

Mon 10/12

3:15 pm-10:29 pm

2 stops38h 14m

$908

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 10/6

6:07 pm-8:25 pm

2 stops19h 18m

Brussels Bruxelles-National

Tue 10/13

7:05 am-8:11 pm

2 stops20h 06m

$934

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sun 10/4

11:04 am-7:50 pm

2 stops25h 46m

Brussels Bruxelles-National

Mon 10/12

3:15 pm-10:29 pm

2 stops38h 14m

$942

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 10/6

11:30 am-9:00 am

1 stop14h 30m

Brussels Bruxelles-National

Tue 10/13

9:25 am-4:16 pm

2 stops37h 51m

$961

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sun 10/4

5:00 am-7:10 am

2 stops19h 10m

Brussels Bruxelles-National

Wed 10/14

9:25 am-10:20 am

2 stops31h 55m

$965

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 10/3

6:45 pm-7:10 am

2 stops29h 25m

Brussels Bruxelles-National

Wed 10/14

9:25 am-10:20 am

2 stops31h 55m

$970

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sun 10/4

2:15 pm-2:35 pm

2 stops17h 20m

Brussels Bruxelles-National

Tue 10/13

10:20 am-10:29 pm

2 stops19h 09m

$977

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 10/6

3:15 pm-1:15 pm

2 stops15h 00m

Brussels Bruxelles-National

Tue 10/13

10:15 am-5:33 pm

1 stop14h 18m

$978
Quickest round-trip

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 10/6

3:15 pm-9:00 am

1 stop10h 45m

Brussels Bruxelles-National

Tue 10/13

10:15 am-7:25 pm

1 stop16h 10m

$981

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 10/7

3:15 pm-1:15 pm

2 stops15h 00m

Brussels Bruxelles-National

Fri 10/16

12:00 pm-11:01 pm

2 stops18h 01m

$982

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Brussels from

How to get the cheapest flight ticket from Des Moines to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Brussels Bruxelles-National?

British Airways, United Airlines, and American Airlines are the most popular carriers operating from Des Moines to Brussels Bruxelles-National

When to book flights from Des Moines to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Brussels Bruxelles-National Airport (DSM to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Brussels Bruxelles-National Airport

Fastest flight time

13h 10m

Direct flights

None
The fastest flight from Des Moines to Brussels Bruxelles-National Airport takes 13h 10m
There are no direct flights from Des Moines to Brussels Bruxelles-National Airport. There are no popular flight routes from Des Moines to Brussels Bruxelles-National Airport.
Search flight deals

Frequently asked questions about flying from Des Moines to Brussels Bruxelles-National Airport

  • How far is Des Moines to Brussels Bruxelles-National by plane?

    There are 4374.0 mi between Des Moines and Brussels Bruxelles-National. Flights usually cover this in 13h 10m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

    Prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from Des Moines Airport to Brussels Bruxelles-National Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The travel and health documents required for your trip to Brussels Bruxelles-National Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Brussels Bruxelles-National Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Brussels Bruxelles-National Airport?

Best airlines flying from Des Moines to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Des Moines to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $707Free CancellationRating
7.4
9,726 reviews
Search United Airlines flights

Traveling to a place near Brussels?

Book flights to Brussels if you plan to visit one of these locations
Bruges
Ghent
Leuven
Charleroi
Zaventem
Mons
Hasselt
Durbuy
Genk
Dinant
Namur
Waterloo
Aalst
Mechelen
Knokke-Heist
Spa
Francorchamps
Tournai
Oostkamp
Halle

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Brussels?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Brussels for you.

Can I find flights from Des Moines to Brussels with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Brussels flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Brussels?

Once you have performed a search for Des Moines to Brussels flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Brussels right now. Can momondo alert me if prices change?

Price alerts on flights to Brussels from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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