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Cheap flights from Des Moines to Brussels from $511

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Brussels departing on 8/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Brussels

Cheap round-trip flights

Enter your travel dates to find the best prices.
Lufthansa Logo
6:15 am - 8:55 am
DSM
-
BRU
19h 40m
1 stop
Lufthansa Logo
10:10 am - 5:33 pm
BRU
-
DSM
14h 23m
1 stop
$782Lufthansa
Wed, Dec 2 - Wed, Dec 9
United Airlines Logo
3:15 pm - 1:15 pm
DSM
-
BRU
15h 00m
2 stops
United Airlines Logo
10:10 am - 11:01 pm
BRU
-
DSM
19h 51m
1 stop
$786United Airlines
Wed, Dec 2 - Wed, Dec 9
United Airlines Logo
1:45 pm - 1:15 pm
DSM
-
BRU
16h 30m
2 stops
United Airlines Logo
10:00 am - 11:01 pm
BRU
-
DSM
20h 01m
2 stops
$789United Airlines
Wed, Dec 2 - Wed, Dec 9
United Airlines Logo
11:30 am - 8:55 am
DSM
-
BRU
14h 25m
1 stop
United Airlines Logo
10:10 am - 11:40 pm
BRU
-
DSM
20h 30m
1 stop
$790United Airlines
Wed, Dec 2 - Wed, Dec 9
Multiple Airlines Logo
6:15 am - 7:50 am
DSM
-
BRU
18h 35m
3 stops
Multiple Airlines Logo
10:00 am - 9:17 pm
BRU
-
DSM
18h 17m
2 stops
$804Multiple Airlines
Wed, Dec 2 - Wed, Dec 9
Air Canada Logo
8:00 am - 7:50 am
DSM
-
BRU
16h 50m
3 stops
Air Canada Logo
7:00 am - 7:25 pm
BRU
-
DSM
19h 25m
3 stops
$815Air Canada
Wed, Dec 2 - Wed, Dec 9
Air Canada Logo
11:32 am - 7:10 am
DSM
-
BRU
12h 38m
2 stops
Air Canada Logo
9:30 am - 10:26 am
BRU
-
DSM
31h 56m
2 stops
$832Air Canada
Tue, Aug 11 - Tue, Aug 18
KLM Logo
5:40 am - 7:40 am
DSM
-
BRU
19h 00m
1 stop
KLM Logo
9:45 am - 10:37 pm
BRU
-
DSM
19h 52m
1 stop
$857KLM
Tue, Aug 11 - Tue, Aug 18
Multiple Airlines Logo
10:23 am - 7:35 am
DSM
-
BRU
14h 12m
2 stops
Multiple Airlines Logo
9:45 am - 10:37 pm
BRU
-
DSM
19h 52m
1 stop
$867Multiple Airlines
Tue, Aug 11 - Tue, Aug 18
Air Canada Logo
11:32 am - 7:10 am
DSM
-
BRU
12h 38m
2 stops
Air Canada Logo
9:30 am - 10:26 am
BRU
-
DSM
31h 56m
2 stops
$885Air Canada
Tue, Aug 11 - Tue, Aug 18

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KLM flights from Des Moines to Brussels Bruxelles-National Airport

Our best KLM deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
KLM
Aug 11
DSM5:40 amDes Moines
19h 00m
1 stop
BRU7:40 amBrussels Bruxelles-National
Aug 18
BRU9:45 amBrussels Bruxelles-National
19h 52m
1 stop
DSM10:37 pmDes Moines
$857
KLM
Oct 6
DSM11:27 amDes Moines
13h 13m
1 stop
BRU7:40 amBrussels Bruxelles-National
Oct 13
BRU9:45 amBrussels Bruxelles-National
19h 44m
1 stop
DSM10:29 pmDes Moines
$924
KLM
Aug 13
DSM5:56 pmDes Moines
13h 44m
2 stops
BRU2:40 pmBrussels Bruxelles-National
Aug 20
BRU9:45 amBrussels Bruxelles-National
15h 05m
1 stop
DSM5:50 pmDes Moines
$948

Air France flights from Des Moines to Brussels Bruxelles-National Airport

Our best Air France deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
Air France
Aug 12
DSM10:59 amDes Moines
13h 41m
2 stops
BRU7:40 amBrussels Bruxelles-National
Aug 19
BRU9:45 amBrussels Bruxelles-National
15h 05m
1 stop
DSM5:50 pmDes Moines
$904
Air France
Aug 13
DSM11:28 amDes Moines
13h 12m
1 stop
BRU7:40 amBrussels Bruxelles-National
Aug 20
BRU9:45 amBrussels Bruxelles-National
19h 52m
1 stop
DSM10:37 pmDes Moines
$945
Air France
Aug 13
DSM11:28 amDes Moines
13h 12m
1 stop
BRU7:40 amBrussels Bruxelles-National
Aug 20
BRU9:45 amBrussels Bruxelles-National
19h 52m
1 stop
DSM10:37 pmDes Moines
$947

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 2, 2026.
Use the filters below to find and compare flights from Des Moines to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 12/2

6:15 am-8:55 am

1 stop19h 40m

Brussels Bruxelles-National

Wed 12/9

10:10 am-5:33 pm

1 stop14h 23m

$782

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 12/2

3:15 pm-1:15 pm

2 stops15h 00m

Brussels Bruxelles-National

Wed 12/9

10:10 am-11:01 pm

1 stop19h 51m

$786

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 12/2

1:45 pm-1:15 pm

2 stops16h 30m

Brussels Bruxelles-National

Wed 12/9

10:00 am-11:01 pm

2 stops20h 01m

$789

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 12/2

11:30 am-8:55 am

1 stop14h 25m

Brussels Bruxelles-National

Wed 12/9

10:10 am-11:40 pm

1 stop20h 30m

$790

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 12/2

6:15 am-7:50 am

3 stops18h 35m

Brussels Bruxelles-National

Wed 12/9

10:00 am-9:17 pm

2 stops18h 17m

$804

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 12/2

8:00 am-7:50 am

3 stops16h 50m

Brussels Bruxelles-National

Wed 12/9

7:00 am-7:25 pm

3 stops19h 25m

$815

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 8/11

11:32 am-7:10 am

2 stops12h 38m

Brussels Bruxelles-National

Tue 8/18

9:30 am-10:26 am

2 stops31h 56m

$832

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 8/11

5:40 am-7:40 am

1 stop19h 00m

Brussels Bruxelles-National

Tue 8/18

9:45 am-10:37 pm

1 stop19h 52m

$857

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 8/11

10:23 am-7:35 am

2 stops14h 12m

Brussels Bruxelles-National

Tue 8/18

9:45 am-10:37 pm

1 stop19h 52m

$867

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 8/11

11:32 am-7:10 am

2 stops12h 38m

Brussels Bruxelles-National

Tue 8/18

9:30 am-10:26 am

2 stops31h 56m

$885

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Brussels from

How to get the cheapest flight ticket from Des Moines to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Brussels Bruxelles-National Airport flights?

You could potentially save up to 11% on your flight if you consider stops on a Des Moines to Brussels Bruxelles-National Airport flight.

When to book flights from Des Moines to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Brussels Bruxelles-National Airport (DSM to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Brussels Bruxelles-National Airport

Fastest flight time

10h 49m

Direct flights

None
The fastest flight from Des Moines to Brussels Bruxelles-National Airport takes 10h 49m
There are no direct flights from Des Moines to Brussels Bruxelles-National Airport. There are no popular flight routes from Des Moines to Brussels Bruxelles-National Airport.
Search flight deals

Frequently asked questions about flying from Des Moines to Brussels Bruxelles-National Airport

  • How far is Des Moines to Brussels Bruxelles-National by plane?

    There are 4374.0 mi between Des Moines and Brussels Bruxelles-National. Flights usually cover this in 10h 49m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

    Prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from Des Moines Airport to Brussels Bruxelles-National Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The travel and health documents required for your trip to Brussels Bruxelles-National Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Brussels Bruxelles-National Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Brussels Bruxelles-National Airport?

Best airlines flying from Des Moines to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Des Moines to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $707Free CancellationRating
7.4
9,926 reviews
Search United Airlines flights

Traveling to a place near Brussels?

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Ghent
Leuven
Charleroi
Zaventem
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Hasselt
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Dinant
Genk
Waterloo
Namur
Aalst
Mechelen
Knokke-Heist
Francorchamps
Spa
Tournai
Oostkamp
Halle

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Brussels?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Brussels for you.

Can I find flights from Des Moines to Brussels with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Brussels flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Brussels?

Once you have performed a search for Des Moines to Brussels flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Brussels right now. Can momondo alert me if prices change?

Price alerts on flights to Brussels from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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