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Cheap flights from Des Moines to Brussels from $329

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Brussels departing on 5/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Brussels

Cheap round-trip flights

Enter your travel dates to find the best prices.
Air Canada Logo
6:48 pm - 7:50 am
DSM
-
BRU
30h 02m2 stops
Air Canada Logo
10:00 am - 9:50 pm
BRU
-
DSM
18h 50m2 stops
$439Air Canada
Tue, Feb 3 - Tue, Feb 10
Lufthansa Logo
11:30 am - 8:55 am
DSM
-
BRU
14h 25m1 stop
Lufthansa Logo
7:00 am - 5:47 pm
BRU
-
DSM
17h 47m2 stops
$449Lufthansa
Tue, Feb 3 - Tue, Feb 10
Lufthansa Logo
6:48 pm - 4:15 pm
DSM
-
BRU
14h 27m2 stops
Lufthansa Logo
10:10 am - 5:47 pm
BRU
-
DSM
14h 37m1 stop
$450Lufthansa
Wed, Feb 4 - Wed, Feb 11
Lufthansa Logo
6:48 pm - 4:15 pm
DSM
-
BRU
14h 27m2 stops
Lufthansa Logo
10:10 am - 5:47 pm
BRU
-
DSM
14h 37m1 stop
$451Lufthansa
Wed, Feb 4 - Wed, Feb 11
Lufthansa Logo
6:48 pm - 4:15 pm
DSM
-
BRU
14h 27m2 stops
Lufthansa Logo
10:10 am - 5:47 pm
BRU
-
DSM
14h 37m1 stop
$452Lufthansa
Wed, Feb 4 - Wed, Feb 11
Lufthansa Logo
11:30 am - 8:55 am
DSM
-
BRU
14h 25m1 stop
Lufthansa Logo
10:10 am - 5:47 pm
BRU
-
DSM
14h 37m1 stop
$456Lufthansa
Tue, Feb 3 - Tue, Feb 10
Lufthansa Logo
11:30 am - 8:55 am
DSM
-
BRU
14h 25m1 stop
Lufthansa Logo
10:10 am - 5:47 pm
BRU
-
DSM
14h 37m1 stop
$457Lufthansa
Tue, Feb 3 - Tue, Feb 10
Lufthansa Logo
11:30 am - 8:55 am
DSM
-
BRU
14h 25m1 stop
Lufthansa Logo
10:10 am - 5:47 pm
BRU
-
DSM
14h 37m1 stop
$458Lufthansa
Tue, Feb 3 - Tue, Feb 10
Lufthansa Logo
11:30 am - 8:55 am
DSM
-
BRU
14h 25m1 stop
Lufthansa Logo
10:10 am - 5:47 pm
BRU
-
DSM
14h 37m1 stop
$459Lufthansa
Tue, Feb 3 - Tue, Feb 10
Multiple Airlines Logo
3:35 pm - 1:15 pm
DSM
-
BRU
14h 40m2 stops
Multiple Airlines Logo
10:10 am - 10:30 pm
BRU
-
DSM
19h 20m2 stops
$474Multiple Airlines
Wed, Feb 4 - Wed, Feb 11

Air Canada flights from Des Moines to Brussels Bruxelles-National Airport

Our best Air Canada deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
Air Canada
Feb 3
DSM6:48 pmDes Moines
30h 02m
2 stops
BRU7:50 amBrussels Bruxelles-National
Feb 10
BRU10:00 amBrussels Bruxelles-National
18h 50m
2 stops
DSM9:50 pmDes Moines
$439
Find similar
Air Canada
Feb 3
DSM6:48 pmDes Moines
30h 02m
2 stops
BRU7:50 amBrussels Bruxelles-National
Feb 10
BRU10:00 amBrussels Bruxelles-National
18h 50m
2 stops
DSM9:50 pmDes Moines
$475
Find similar
Air Canada
Feb 3
DSM6:48 pmDes Moines
30h 02m
2 stops
BRU7:50 amBrussels Bruxelles-National
Feb 10
BRU10:00 amBrussels Bruxelles-National
18h 50m
2 stops
DSM9:50 pmDes Moines
$483
Find similar

Lufthansa flights from Des Moines to Brussels Bruxelles-National Airport

Our best Lufthansa deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
Lufthansa
Feb 3
DSM11:30 amDes Moines
14h 25m
1 stop
BRU8:55 amBrussels Bruxelles-National
Feb 10
BRU7:00 amBrussels Bruxelles-National
17h 47m
2 stops
DSM5:47 pmDes Moines
$449
Find similar
Lufthansa
Feb 4
DSM6:48 pmDes Moines
14h 27m
2 stops
BRU4:15 pmBrussels Bruxelles-National
Feb 11
BRU10:10 amBrussels Bruxelles-National
14h 37m
1 stop
DSM5:47 pmDes Moines
$450
Find similar
Lufthansa
Feb 4
DSM6:48 pmDes Moines
14h 27m
2 stops
BRU4:15 pmBrussels Bruxelles-National
Feb 11
BRU10:10 amBrussels Bruxelles-National
14h 37m
1 stop
DSM5:47 pmDes Moines
$451
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 21, 2025.
Use the filters below to find and compare flights from Des Moines to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 2/3

6:48 pm-7:50 am

2 stops30h 02m

Brussels Bruxelles-National

Tue 2/10

10:00 am-9:50 pm

2 stops18h 50m

$439

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 2/3

11:30 am-8:55 am

1 stop14h 25m

Brussels Bruxelles-National

Tue 2/10

7:00 am-5:47 pm

2 stops17h 47m

$449

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 2/4

6:48 pm-4:15 pm

2 stops14h 27m

Brussels Bruxelles-National

Wed 2/11

10:10 am-5:47 pm

1 stop14h 37m

$450

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 2/4

6:48 pm-4:15 pm

2 stops14h 27m

Brussels Bruxelles-National

Wed 2/11

10:10 am-5:47 pm

1 stop14h 37m

$451

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 2/4

6:48 pm-4:15 pm

2 stops14h 27m

Brussels Bruxelles-National

Wed 2/11

10:10 am-5:47 pm

1 stop14h 37m

$452

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 2/3

11:30 am-8:55 am

1 stop14h 25m

Brussels Bruxelles-National

Tue 2/10

10:10 am-5:47 pm

1 stop14h 37m

$456

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 2/3

11:30 am-8:55 am

1 stop14h 25m

Brussels Bruxelles-National

Tue 2/10

10:10 am-5:47 pm

1 stop14h 37m

$457

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 2/3

11:30 am-8:55 am

1 stop14h 25m

Brussels Bruxelles-National

Tue 2/10

10:10 am-5:47 pm

1 stop14h 37m

$458

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 2/3

11:30 am-8:55 am

1 stop14h 25m

Brussels Bruxelles-National

Tue 2/10

10:10 am-5:47 pm

1 stop14h 37m

$459

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 2/4

3:35 pm-1:15 pm

2 stops14h 40m

Brussels Bruxelles-National

Wed 2/11

10:10 am-10:30 pm

2 stops19h 20m

$474

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Brussels from

How to get the cheapest flight ticket from Des Moines to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Brussels Bruxelles-National Airport?

The cheapest day to depart from Des Moines to Brussels Bruxelles-National Airport is on a Wednesday. Travelers who choose to depart for Brussels Bruxelles-National Airport on a Wednesday will often find tickets for as low as $864. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Brussels Bruxelles-National Airport for around $1,370.

What is the cheapest time of day to depart on your flight to Brussels Bruxelles-National Airport?

Our most recent data shows that the best time of day to fly to Brussels Bruxelles-National Airport is in the morning. Flights from Des Moines to Brussels Bruxelles-National Airport during this time can be as low as $852. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $932 on average. Flights to Brussels Bruxelles-National Airport from Des Moines in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

When to book flights from Des Moines to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Brussels Bruxelles-National Airport (DSM to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Brussels Bruxelles-National Airport

Fastest flight time

14h 25m

Direct flights

None
The fastest flight from Des Moines to Brussels Bruxelles-National Airport takes 14h 25m
There are no direct flights from Des Moines to Brussels Bruxelles-National Airport. There are no popular flight routes from Des Moines to Brussels Bruxelles-National Airport.
Search flight deals

  • How far is Des Moines to Brussels Bruxelles-National by plane?

    There are 4374.0 mi between Des Moines and Brussels Bruxelles-National. Flights usually cover this in 14h 25m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

    Prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from Des Moines Airport to Brussels Bruxelles-National Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The travel and health documents required for your trip to Brussels Bruxelles-National Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Brussels Bruxelles-National Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Brussels Bruxelles-National Airport?

Best airlines flying from Des Moines to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Des Moines to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $707Free CancellationRating
7.4
9,099 reviews
Search United Airlines flights

Traveling to a place near Brussels?

Book flights to Brussels if you plan to visit one of these locations
Bruges
Ghent
Leuven
Charleroi
Hasselt
Spa
Zaventem
Namur
Dinant
Genk
Mons
Durbuy
Waterloo
Aalst
Mechelen
Francorchamps
Knokke-Heist
Tournai
Oostkamp
Halle

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Brussels?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Brussels for you.

Can I find flights from Des Moines to Brussels with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Brussels flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Brussels?

Once you have performed a search for Des Moines to Brussels flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Brussels right now. Can momondo alert me if prices change?

Price alerts on flights to Brussels from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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