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Cheap flights from Des Moines to Brussels from $359

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Brussels departing on 5/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Brussels

Cheap round-trip flights

Enter your travel dates to find the best prices.
Air Canada Logo
6:49 pm - 7:50 am
DSM
-
BRU
31h 01m
2 stops
Air Canada Logo
10:00 am - 10:30 am
BRU
-
DSM
30h 30m
2 stops
$476Air Canada
Wed, Mar 18 - Wed, Mar 25
United Airlines Logo
8:00 am - 1:15 pm
DSM
-
BRU
23h 15m
2 stops
United Airlines Logo
10:00 am - 1:23 pm
BRU
-
DSM
33h 23m
2 stops
$487United Airlines
Wed, Mar 18 - Wed, Mar 25
United Airlines Logo
3:28 pm - 7:55 am
DSM
-
BRU
10h 27m
1 stop
United Airlines Logo
10:00 am - 1:23 pm
BRU
-
DSM
33h 23m
2 stops
$490United Airlines
Wed, Mar 18 - Wed, Mar 25
Air Canada Logo
3:28 pm - 7:50 am
DSM
-
BRU
34h 22m
2 stops
Air Canada Logo
10:00 am - 1:23 pm
BRU
-
DSM
33h 23m
2 stops
$493Air Canada
Mon, Mar 9 - Mon, Mar 16
KLM Logo
5:35 am - 8:00 am
DSM
-
BRU
20h 25m
1 stop
KLM Logo
10:00 am - 10:38 pm
BRU
-
DSM
18h 38m
1 stop
$495KLM
Mon, Mar 9 - Mon, Mar 16
KLM Logo
5:20 pm - 8:00 am
DSM
-
BRU
32h 40m
1 stop
KLM Logo
10:00 am - 10:38 pm
BRU
-
DSM
18h 38m
1 stop
$496KLM
Thu, Mar 19 - Thu, Mar 26
KLM Logo
5:20 pm - 8:00 am
DSM
-
BRU
32h 40m
1 stop
KLM Logo
10:00 am - 10:38 pm
BRU
-
DSM
18h 38m
1 stop
$500KLM
Thu, Mar 19 - Thu, Mar 26
KLM Logo
5:20 pm - 8:00 am
DSM
-
BRU
32h 40m
1 stop
KLM Logo
10:00 am - 10:38 pm
BRU
-
DSM
18h 38m
1 stop
$501KLM
Thu, Mar 19 - Thu, Mar 26
Air Canada Logo
2:04 pm - 7:50 am
DSM
-
BRU
35h 46m
2 stops
Air Canada Logo
10:00 am - 10:30 am
BRU
-
DSM
30h 30m
2 stops
$502Air Canada
Mon, Mar 9 - Mon, Mar 16
KLM Logo
5:20 pm - 8:00 am
DSM
-
BRU
32h 40m
1 stop
KLM Logo
10:00 am - 10:38 pm
BRU
-
DSM
18h 38m
1 stop
$505KLM
Tue, Mar 10 - Tue, Mar 17

Delta flights from Des Moines to Brussels Bruxelles-National Airport

Our best Delta deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
Delta
Mar 19
DSM6:15 amDes Moines
21h 55m
2 stops
BRU10:10 amBrussels Bruxelles-National
Mar 26
BRU10:00 amBrussels Bruxelles-National
18h 38m
1 stop
DSM10:38 pmDes Moines
$520
Delta
Mar 18
DSM11:33 amDes Moines
14h 27m
1 stop
BRU8:00 amBrussels Bruxelles-National
Mar 25
BRU2:45 pmBrussels Bruxelles-National
26h 03m
2 stops
DSM10:48 amDes Moines
$594
Delta
Mar 18
DSM5:35 amDes Moines
20h 25m
1 stop
BRU8:00 amBrussels Bruxelles-National
Mar 25
BRU10:45 amBrussels Bruxelles-National
30h 03m
2 stops
DSM10:48 amDes Moines
$595

United Airlines flights from Des Moines to Brussels Bruxelles-National Airport

Our best United Airlines deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
United Airlines
Mar 18
DSM8:00 amDes Moines
23h 15m
2 stops
BRU1:15 pmBrussels Bruxelles-National
Mar 25
BRU10:00 amBrussels Bruxelles-National
33h 23m
2 stops
DSM1:23 pmDes Moines
$487
United Airlines
Mar 18
DSM3:28 pmDes Moines
10h 27m
1 stop
BRU7:55 amBrussels Bruxelles-National
Mar 25
BRU10:00 amBrussels Bruxelles-National
33h 23m
2 stops
DSM1:23 pmDes Moines
$490
United Airlines
Mar 20
DSM7:15 amDes Moines
24h 00m
2 stops
BRU1:15 pmBrussels Bruxelles-National
Mar 27
BRU10:10 amBrussels Bruxelles-National
30h 18m
1 stop
DSM10:28 amDes Moines
$561

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 6, 2026.
Use the filters below to find and compare flights from Des Moines to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 3/18

6:49 pm-7:50 am

2 stops31h 01m

Brussels Bruxelles-National

Wed 3/25

10:00 am-10:30 am

2 stops30h 30m

$476

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 3/18

8:00 am-1:15 pm

2 stops23h 15m

Brussels Bruxelles-National

Wed 3/25

10:00 am-1:23 pm

2 stops33h 23m

$487

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 3/18

3:28 pm-7:55 am

1 stop10h 27m

Brussels Bruxelles-National

Wed 3/25

10:00 am-1:23 pm

2 stops33h 23m

$490

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 3/9

3:28 pm-7:50 am

2 stops34h 22m

Brussels Bruxelles-National

Mon 3/16

10:00 am-1:23 pm

2 stops33h 23m

$493

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 3/9

5:35 am-8:00 am

1 stop20h 25m

Brussels Bruxelles-National

Mon 3/16

10:00 am-10:38 pm

1 stop18h 38m

$495

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 3/19

5:20 pm-8:00 am

1 stop32h 40m

Brussels Bruxelles-National

Thu 3/26

10:00 am-10:38 pm

1 stop18h 38m

$496

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 3/19

5:20 pm-8:00 am

1 stop32h 40m

Brussels Bruxelles-National

Thu 3/26

10:00 am-10:38 pm

1 stop18h 38m

$500

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 3/19

5:20 pm-8:00 am

1 stop32h 40m

Brussels Bruxelles-National

Thu 3/26

10:00 am-10:38 pm

1 stop18h 38m

$501

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 3/9

2:04 pm-7:50 am

2 stops35h 46m

Brussels Bruxelles-National

Mon 3/16

10:00 am-10:30 am

2 stops30h 30m

$502

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 3/10

5:20 pm-8:00 am

1 stop32h 40m

Brussels Bruxelles-National

Tue 3/17

10:00 am-10:38 pm

1 stop18h 38m

$505

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Brussels from

How to get the cheapest flight ticket from Des Moines to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Brussels Bruxelles-National?

Aer Lingus and Air Canada are the most popular carriers operating from Des Moines to Brussels Bruxelles-National

When to book flights from Des Moines to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Brussels Bruxelles-National Airport (DSM to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Brussels Bruxelles-National Airport

Fastest flight time

13h 46m

Direct flights

None
The fastest flight from Des Moines to Brussels Bruxelles-National Airport takes 13h 46m
There are no direct flights from Des Moines to Brussels Bruxelles-National Airport. There are no popular flight routes from Des Moines to Brussels Bruxelles-National Airport.
Search flight deals

  • How far is Des Moines to Brussels Bruxelles-National by plane?

    There are 4374.0 mi between Des Moines and Brussels Bruxelles-National. Flights usually cover this in 13h 46m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

    Prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from Des Moines Airport to Brussels Bruxelles-National Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The travel and health documents required for your trip to Brussels Bruxelles-National Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Brussels Bruxelles-National Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Brussels Bruxelles-National Airport?

Best airlines flying from Des Moines to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Des Moines to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $707Free CancellationRating
7.4
9,240 reviews
Search United Airlines flights

Traveling to a place near Brussels?

Book flights to Brussels if you plan to visit one of these locations
Ghent
Bruges
Leuven
Charleroi
Zaventem
Hasselt
Spa
Namur
Dinant
Genk
Mons
Waterloo
Durbuy
Aalst
Knokke-Heist
Mechelen
Francorchamps
Tournai
Oostkamp
Halle

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Brussels?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Brussels for you.

Can I find flights from Des Moines to Brussels with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Brussels flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Brussels?

Once you have performed a search for Des Moines to Brussels flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Brussels right now. Can momondo alert me if prices change?

Price alerts on flights to Brussels from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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