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Cheap flights from Des Moines to Brussels from $545

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Brussels departing on 10/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Brussels

Cheap round-trip flights

Scandinavian Airlines Logo
2:13 pm - 9:40 amDSM-BRU
37h 27m2 stops
Scandinavian Airlines Logo
3:10 pm - 10:30 pmBRU-DSM
38h 20m2 stops
$554Scandinavian Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6
Scandinavian Airlines Logo
2:13 pm - 9:40 amDSM-BRU
37h 27m2 stops
Scandinavian Airlines Logo
3:10 pm - 10:30 pmBRU-DSM
38h 20m2 stops
$573Scandinavian Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6
Multiple Airlines Logo
5:04 am - 10:30 pmDSM-BRU
35h 26m2 stops
Multiple Airlines Logo
7:10 pm - 10:59 pmBRU-DSM
34h 49m2 stops
$675Multiple Airlines
Find Deal
Thu, Oct 30 - Thu, Nov 6
Delta Logo
10:00 am - 2:15 pmDSM-BRU
22h 15m2 stops
Delta Logo
11:00 am - 10:05 amBRU-DSM
30h 05m2 stops
$676Delta
Find Deal
Thu, Oct 30 - Thu, Nov 6
Delta Logo
2:13 pm - 2:15 pmDSM-BRU
18h 02m2 stops
Delta Logo
11:00 am - 9:20 amBRU-DSM
29h 20m2 stops
$716Delta
Find Deal
Thu, Oct 30 - Thu, Nov 6
Multiple Airlines Logo
5:04 am - 6:25 pmDSM-BRU
31h 21m2 stops
Multiple Airlines Logo
7:05 am - 10:59 pmBRU-DSM
22h 54m2 stops
$787Multiple Airlines
Find Deal
Fri, Oct 31 - Fri, Nov 7
United Airlines Logo
3:15 pm - 12:35 pmDSM-BRU
15h 20m2 stops
United Airlines Logo
10:10 am - 9:32 pmBRU-DSM
18h 22m1 stop
$862United Airlines
Find Deal
Fri, Oct 31 - Fri, Nov 7
United Airlines Logo
3:15 pm - 12:35 pmDSM-BRU
15h 20m2 stops
United Airlines Logo
10:10 am - 9:32 pmBRU-DSM
18h 22m1 stop
$866United Airlines
Find Deal
Fri, Oct 31 - Fri, Nov 7
Air Canada Logo
1:05 pm - 7:55 amDSM-BRU
12h 50m1 stop
Air Canada Logo
10:10 am - 5:25 pmBRU-DSM
14h 15m1 stop
$964Air Canada
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Thu, Oct 30 - Thu, Nov 6
Air Canada Logo
3:15 pm - 7:55 amDSM-BRU
10h 40m1 stop
Air Canada Logo
10:10 am - 9:32 pmBRU-DSM
18h 22m1 stop
$982Air Canada
Find Deal
Fri, Oct 31 - Fri, Nov 7

Delta flights from Des Moines to Brussels Bruxelles-National Airport

Our best Delta deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
Delta
Oct 30
DSM10:00 amDes Moines
22h 15m
2 stops
BRU2:15 pmBrussels Bruxelles-National
Nov 6
BRU11:00 amBrussels Bruxelles-National
30h 05m
2 stops
DSM10:05 amDes Moines
$676
Find similar
Delta
Oct 30
DSM2:13 pmDes Moines
18h 02m
2 stops
BRU2:15 pmBrussels Bruxelles-National
Nov 6
BRU11:00 amBrussels Bruxelles-National
29h 20m
2 stops
DSM9:20 amDes Moines
$716
Find similar
Delta
Sep 19
DSM10:55 amDes Moines
14h 45m
2 stops
BRU8:40 amBrussels Bruxelles-National
Sep 21
BRU10:45 amBrussels Bruxelles-National
14h 00m
1 stop
DSM5:45 pmDes Moines
$1,701
Find similar

Air Canada flights from Des Moines to Brussels Bruxelles-National Airport

Our best Air Canada deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
Air Canada
Oct 30
DSM1:05 pmDes Moines
12h 50m
1 stop
BRU7:55 amBrussels Bruxelles-National
Nov 6
BRU10:10 amBrussels Bruxelles-National
14h 15m
1 stop
DSM5:25 pmDes Moines
$964
Find similar
Air Canada
Oct 31
DSM3:15 pmDes Moines
10h 40m
1 stop
BRU7:55 amBrussels Bruxelles-National
Nov 7
BRU10:10 amBrussels Bruxelles-National
18h 22m
1 stop
DSM9:32 pmDes Moines
$982
Find similar
Air Canada
Nov 1
DSM3:15 pmDes Moines
10h 40m
1 stop
BRU7:55 amBrussels Bruxelles-National
Nov 8
BRU11:55 amBrussels Bruxelles-National
16h 37m
2 stops
DSM9:32 pmDes Moines
$1,178
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 10/30

2:13 pm-9:40 am

2 stops37h 27m

Brussels Bruxelles-National

Thu 11/6

3:10 pm-10:30 pm

2 stops38h 20m

$554

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 10/30

2:13 pm-9:40 am

2 stops37h 27m

Brussels Bruxelles-National

Thu 11/6

3:10 pm-10:30 pm

2 stops38h 20m

$573

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 10/30

5:04 am-10:30 pm

2 stops35h 26m

Brussels Bruxelles-National

Thu 11/6

7:10 pm-10:59 pm

2 stops34h 49m

$675

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 10/30

10:00 am-2:15 pm

2 stops22h 15m

Brussels Bruxelles-National

Thu 11/6

11:00 am-10:05 am

2 stops30h 05m

$676

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 10/30

2:13 pm-2:15 pm

2 stops18h 02m

Brussels Bruxelles-National

Thu 11/6

11:00 am-9:20 am

2 stops29h 20m

$716

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 10/31

5:04 am-6:25 pm

2 stops31h 21m

Brussels Bruxelles-National

Fri 11/7

7:05 am-10:59 pm

2 stops22h 54m

$787

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 10/31

3:15 pm-12:35 pm

2 stops15h 20m

Brussels Bruxelles-National

Fri 11/7

10:10 am-9:32 pm

1 stop18h 22m

$862

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 10/31

3:15 pm-12:35 pm

2 stops15h 20m

Brussels Bruxelles-National

Fri 11/7

10:10 am-9:32 pm

1 stop18h 22m

$866

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Thu 10/30

1:05 pm-7:55 am

1 stop12h 50m

Brussels Bruxelles-National

Thu 11/6

10:10 am-5:25 pm

1 stop14h 15m

$964

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 10/31

3:15 pm-7:55 am

1 stop10h 40m

Brussels Bruxelles-National

Fri 11/7

10:10 am-9:32 pm

1 stop18h 22m

$982

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Brussels from

How to get the cheapest flight ticket from Des Moines to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Brussels Bruxelles-National Airport?

The cheapest day to depart from Des Moines to Brussels Bruxelles-National Airport is on a Wednesday. Travelers who choose to depart for Brussels Bruxelles-National Airport on a Wednesday will often find tickets for as low as $864. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Brussels Bruxelles-National Airport for around $1,370.

What is the cheapest time of day to depart on your flight to Brussels Bruxelles-National Airport?

Our most recent data shows that the best time of day to fly to Brussels Bruxelles-National Airport is in the morning. Flights from Des Moines to Brussels Bruxelles-National Airport during this time can be as low as $852. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $932 on average. Flights to Brussels Bruxelles-National Airport from Des Moines in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

When to book flights from Des Moines to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Brussels Bruxelles-National Airport (DSM to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Brussels Bruxelles-National Airport

Direct flights

None
There are no direct flights from Des Moines to Brussels Bruxelles-National Airport. There are no popular flight routes from Des Moines to Brussels Bruxelles-National Airport.
Search flight deals

  • How far is Des Moines to Brussels Bruxelles-National by plane?

    There are 4374.0 mi between Des Moines and Brussels Bruxelles-National. Flights usually cover this in 10h 40m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

    Prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from Des Moines Airport to Brussels Bruxelles-National Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The travel and health documents required for your trip to Brussels Bruxelles-National Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Brussels Bruxelles-National Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Brussels Bruxelles-National Airport?

Best airlines flying from Des Moines to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Des Moines to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $705Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights

Traveling to a place near Brussels?

Book flights to Brussels if you plan to visit one of these locations
Bruges
Ghent
Leuven
Charleroi
Hasselt
Spa
Namur
Aalst
Dinant
Mons
Zaventem
Waterloo
Genk
Mechelen
Francorchamps
Knokke-Heist
Tournai
Durbuy
Oostkamp
Halle

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Brussels?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Brussels for you.

Can I find flights from Des Moines to Brussels with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Brussels flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Brussels?

Once you have performed a search for Des Moines to Brussels flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Brussels right now. Can momondo alert me if prices change?

Price alerts on flights to Brussels from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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