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Cheap flights from Des Moines to Brussels from $419

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Brussels departing on 5/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Brussels

Cheap round-trip flights

Enter your travel dates to find the best prices.
Air Canada Logo
6:15 am - 7:10 am
DSM
-
BRU
17h 55m
2 stops
Air Canada Logo
9:55 am - 11:24 pm
BRU
-
DSM
20h 29m
2 stops
$697Air Canada
Wed, May 6 - Wed, May 13
Air Canada Logo
6:15 am - 7:10 am
DSM
-
BRU
17h 55m
2 stops
Air Canada Logo
9:55 am - 11:24 pm
BRU
-
DSM
20h 29m
2 stops
$734Air Canada
Wed, May 6 - Wed, May 13
Air Canada Logo
6:15 am - 7:10 am
DSM
-
BRU
17h 55m
2 stops
Air Canada Logo
9:55 am - 11:24 pm
BRU
-
DSM
20h 29m
2 stops
$742Air Canada
Mon, May 4 - Mon, May 11
Air Canada Logo
7:05 pm - 7:10 am
DSM
-
BRU
29h 05m
2 stops
Air Canada Logo
9:55 am - 10:37 am
BRU
-
DSM
31h 42m
2 stops
$744Air Canada
Tue, May 5 - Tue, May 12
Air Canada Logo
6:15 am - 7:10 am
DSM
-
BRU
17h 55m
2 stops
Air Canada Logo
9:55 am - 9:23 am
BRU
-
DSM
30h 28m
2 stops
$749Air Canada
Wed, May 6 - Wed, May 13
Multiple Airlines Logo
7:05 pm - 4:15 pm
DSM
-
BRU
14h 10m
2 stops
Multiple Airlines Logo
10:15 am - 9:23 pm
BRU
-
DSM
18h 08m
1 stop
$760Multiple Airlines
Tue, May 5 - Tue, May 12
Air Canada Logo
6:15 am - 7:10 am
DSM
-
BRU
17h 55m
2 stops
Air Canada Logo
9:55 am - 9:23 am
BRU
-
DSM
30h 28m
2 stops
$765Air Canada
Wed, May 6 - Wed, May 13
Air Canada Logo
6:15 am - 7:10 am
DSM
-
BRU
17h 55m
2 stops
Air Canada Logo
9:55 am - 11:24 pm
BRU
-
DSM
20h 29m
2 stops
$768Air Canada
Wed, May 6 - Wed, May 13
Air France Logo
6:31 pm - 7:40 am
DSM
-
BRU
30h 09m
1 stop
Air France Logo
9:45 am - 10:32 pm
BRU
-
DSM
19h 47m
1 stop
$770Air France
Tue, May 5 - Tue, May 12
KLM Logo
5:45 am - 7:40 am
DSM
-
BRU
18h 55m
1 stop
KLM Logo
3:10 pm - 4:48 pm
BRU
-
DSM
32h 38m
2 stops
$774KLM
Mon, May 4 - Mon, May 11

Air France flights from Des Moines to Brussels Bruxelles-National Airport

Our best Air France deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
Air France
May 5
DSM6:31 pmDes Moines
30h 09m
1 stop
BRU7:40 amBrussels Bruxelles-National
May 12
BRU9:45 amBrussels Bruxelles-National
19h 47m
1 stop
DSM10:32 pmDes Moines
$770
Air France
May 4
DSM11:51 amDes Moines
12h 49m
1 stop
BRU7:40 amBrussels Bruxelles-National
May 11
BRU9:45 amBrussels Bruxelles-National
15h 08m
1 stop
DSM5:53 pmDes Moines
$778
Air France
May 4
DSM11:51 amDes Moines
12h 49m
1 stop
BRU7:40 amBrussels Bruxelles-National
May 11
BRU9:45 amBrussels Bruxelles-National
19h 47m
1 stop
DSM10:32 pmDes Moines
$815

KLM flights from Des Moines to Brussels Bruxelles-National Airport

Our best KLM deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
KLM
May 4
DSM5:45 amDes Moines
18h 55m
1 stop
BRU7:40 amBrussels Bruxelles-National
May 11
BRU3:10 pmBrussels Bruxelles-National
32h 38m
2 stops
DSM4:48 pmDes Moines
$774
KLM
May 4
DSM5:45 amDes Moines
18h 55m
1 stop
BRU7:40 amBrussels Bruxelles-National
May 11
BRU3:10 pmBrussels Bruxelles-National
32h 38m
2 stops
DSM4:48 pmDes Moines
$779
KLM
May 4
DSM5:45 amDes Moines
18h 55m
1 stop
BRU7:40 amBrussels Bruxelles-National
May 11
BRU9:45 amBrussels Bruxelles-National
15h 08m
1 stop
DSM5:53 pmDes Moines
$820

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Des Moines to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 5/6

6:15 am-7:10 am

2 stops17h 55m

Brussels Bruxelles-National

Wed 5/13

9:55 am-11:24 pm

2 stops20h 29m

$697

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 5/6

6:15 am-7:10 am

2 stops17h 55m

Brussels Bruxelles-National

Wed 5/13

9:55 am-11:24 pm

2 stops20h 29m

$734

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 5/4

6:15 am-7:10 am

2 stops17h 55m

Brussels Bruxelles-National

Mon 5/11

9:55 am-11:24 pm

2 stops20h 29m

$742

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 5/5

7:05 pm-7:10 am

2 stops29h 05m

Brussels Bruxelles-National

Tue 5/12

9:55 am-10:37 am

2 stops31h 42m

$744

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 5/6

6:15 am-7:10 am

2 stops17h 55m

Brussels Bruxelles-National

Wed 5/13

9:55 am-9:23 am

2 stops30h 28m

$749
Quickest round-trip

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 5/5

7:05 pm-4:15 pm

2 stops14h 10m

Brussels Bruxelles-National

Tue 5/12

10:15 am-9:23 pm

1 stop18h 08m

$760

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 5/6

6:15 am-7:10 am

2 stops17h 55m

Brussels Bruxelles-National

Wed 5/13

9:55 am-9:23 am

2 stops30h 28m

$765

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 5/6

6:15 am-7:10 am

2 stops17h 55m

Brussels Bruxelles-National

Wed 5/13

9:55 am-11:24 pm

2 stops20h 29m

$768

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 5/5

6:31 pm-7:40 am

1 stop30h 09m

Brussels Bruxelles-National

Tue 5/12

9:45 am-10:32 pm

1 stop19h 47m

$770

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Mon 5/4

5:45 am-7:40 am

1 stop18h 55m

Brussels Bruxelles-National

Mon 5/11

3:10 pm-4:48 pm

2 stops32h 38m

$774

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Brussels from

How to get the cheapest flight ticket from Des Moines to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Brussels Bruxelles-National?

Aer Lingus, United Airlines, and Air Canada are the most popular carriers operating from Des Moines to Brussels Bruxelles-National

When to book flights from Des Moines to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Brussels Bruxelles-National Airport (DSM to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Brussels Bruxelles-National Airport

Fastest flight time

10h 27m

Direct flights

None
The fastest flight from Des Moines to Brussels Bruxelles-National Airport takes 10h 27m
There are no direct flights from Des Moines to Brussels Bruxelles-National Airport. There are no popular flight routes from Des Moines to Brussels Bruxelles-National Airport.
Search flight deals

  • How far is Des Moines to Brussels Bruxelles-National by plane?

    There are 4374.0 mi between Des Moines and Brussels Bruxelles-National. Flights usually cover this in 10h 27m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

    Prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from Des Moines Airport to Brussels Bruxelles-National Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The travel and health documents required for your trip to Brussels Bruxelles-National Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Brussels Bruxelles-National Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Brussels Bruxelles-National Airport?

Best airlines flying from Des Moines to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Des Moines to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $707Free CancellationRating
7.4
9,460 reviews
Search United Airlines flights

Traveling to a place near Brussels?

Book flights to Brussels if you plan to visit one of these locations
Ghent
Bruges
Leuven
Charleroi
Zaventem
Hasselt
Genk
Namur
Dinant
Waterloo
Durbuy
Mons
Aalst
Spa
Knokke-Heist
Mechelen
Francorchamps
Tournai
Oostkamp
Halle

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Brussels?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Brussels for you.

Can I find flights from Des Moines to Brussels with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Brussels flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Brussels?

Once you have performed a search for Des Moines to Brussels flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Brussels right now. Can momondo alert me if prices change?

Price alerts on flights to Brussels from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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