Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to Brussels from $456

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Brussels departing on 9/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Brussels

Cheap round-trip flights

Enter your travel dates to find the best prices.
Air Canada Logo
11:27 am - 7:10 amDSM  Des Moines-BRU Brussels Bruxelles-National
12h 43m2 stops Chicago O'Hare Intl Montreal Pierre Elliott Trudeau Intl
Air Canada Logo
9:10 am - 11:35 pmBRU  Brussels Bruxelles-National-DSM Des Moines
21h 25m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$769Air Canada
Tue, Sep 29 - Tue, Oct 6
Air Canada Logo
8:00 am - 7:50 amDSM  Des Moines-BRU Brussels Bruxelles-National
16h 50m2 stops Chicago O'Hare Intl Montreal Pierre Elliott Trudeau Intl
Air Canada Logo
10:00 am - 10:20 amBRU  Brussels Bruxelles-National-DSM Des Moines
31h 20m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$773Air Canada
Mon, Dec 7 - Wed, Dec 9
Air Canada Logo
6:15 am - 7:50 amDSM  Des Moines-BRU Brussels Bruxelles-National
18h 35m2 stops Chicago O'Hare Intl Montreal Pierre Elliott Trudeau Intl
Air Canada Logo
10:00 am - 2:11 pmBRU  Brussels Bruxelles-National-DSM Des Moines
35h 11m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$773Air Canada
Mon, Dec 7 - Wed, Dec 9
Air Canada Logo
6:15 am - 7:50 amDSM  Des Moines-BRU Brussels Bruxelles-National
18h 35m2 stops Chicago O'Hare Intl Montreal Pierre Elliott Trudeau Intl
Air Canada Logo
10:00 am - 2:11 pmBRU  Brussels Bruxelles-National-DSM Des Moines
35h 11m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$774Air Canada
Mon, Dec 7 - Wed, Dec 9
Multiple Airlines Logo
11:30 am - 4:15 pmDSM  Des Moines-BRU Brussels Bruxelles-National
21h 45m2 stops Chicago O'Hare Intl Munich Franz Josef Strauss
Multiple Airlines Logo
10:00 am - 2:11 pmBRU  Brussels Bruxelles-National-DSM Des Moines
35h 11m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$778Multiple Airlines
Thu, Dec 3 - Fri, Dec 11
Air Canada Logo
6:00 am - 7:10 amDSM  Des Moines-BRU Brussels Bruxelles-National
18h 10m2 stops Chicago O'Hare Intl Montreal Pierre Elliott Trudeau Intl
Air Canada Logo
9:10 am - 11:35 pmBRU  Brussels Bruxelles-National-DSM Des Moines
21h 25m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$778Air Canada
Wed, Sep 30 - Wed, Oct 7
Multiple Airlines Logo
11:30 am - 7:55 pmDSM  Des Moines-BRU Brussels Bruxelles-National
25h 25m2 stops Chicago O'Hare Intl Munich Franz Josef Strauss
Multiple Airlines Logo
10:00 am - 2:11 pmBRU  Brussels Bruxelles-National-DSM Des Moines
35h 11m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$779Multiple Airlines
Thu, Dec 3 - Fri, Dec 11
United Airlines Logo
1:45 pm - 1:15 pmDSM  Des Moines-BRU Brussels Bruxelles-National
16h 30m2 stops Denver Intl London Heathrow
United Airlines Logo
10:10 am - 7:25 pmBRU  Brussels Bruxelles-National-DSM Des Moines
16h 15m1 stop Chicago O'Hare Intl
$787United Airlines
Mon, Dec 7 - Wed, Dec 9
United Airlines Logo
11:30 am - 1:15 pmDSM  Des Moines-BRU Brussels Bruxelles-National
18h 45m2 stops Chicago O'Hare Intl London Heathrow
United Airlines Logo
10:10 am - 7:25 pmBRU  Brussels Bruxelles-National-DSM Des Moines
16h 15m1 stop Chicago O'Hare Intl
$787United Airlines
Mon, Dec 7 - Wed, Dec 9
United Airlines Logo
3:11 pm - 9:00 amDSM  Des Moines-BRU Brussels Bruxelles-National
10h 49m1 stop Chicago O'Hare Intl
United Airlines Logo
9:10 am - 10:31 amBRU  Brussels Bruxelles-National-DSM Des Moines
32h 21m2 stops Montreal Pierre Elliott Trudeau Intl Chicago O'Hare Intl
$787United Airlines
Tue, Sep 29 - Tue, Oct 6

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Air Canada flights from Des Moines to Brussels Bruxelles-National Airport

Our best Air Canada deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
Air Canada
Sep 29
DSM11:27 amDes Moines
12h 43m
2 stops
BRU7:10 amBrussels Bruxelles-National
Oct 6
BRU9:10 amBrussels Bruxelles-National
21h 25m
2 stops
DSM11:35 pmDes Moines
$769
Air Canada
Dec 7
DSM6:15 amDes Moines
18h 35m
2 stops
BRU7:50 amBrussels Bruxelles-National
Dec 9
BRU10:00 amBrussels Bruxelles-National
35h 11m
2 stops
DSM2:11 pmDes Moines
$773
Air Canada
Dec 7
DSM6:15 amDes Moines
18h 35m
2 stops
BRU7:50 amBrussels Bruxelles-National
Dec 9
BRU10:00 amBrussels Bruxelles-National
35h 11m
2 stops
DSM2:11 pmDes Moines
$774

United Airlines flights from Des Moines to Brussels Bruxelles-National Airport

Our best United Airlines deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
United Airlines
Dec 7
DSM11:30 amDes Moines
18h 45m
2 stops
BRU1:15 pmBrussels Bruxelles-National
Dec 9
BRU10:10 amBrussels Bruxelles-National
16h 15m
1 stop
DSM7:25 pmDes Moines
$787
United Airlines
Dec 7
DSM11:30 amDes Moines
14h 25m
1 stop
BRU8:55 amBrussels Bruxelles-National
Dec 9
BRU10:10 amBrussels Bruxelles-National
14h 23m
1 stop
DSM5:33 pmDes Moines
$790
United Airlines
Dec 3
DSM3:15 pmDes Moines
15h 00m
2 stops
BRU1:15 pmBrussels Bruxelles-National
Dec 11
BRU10:10 amBrussels Bruxelles-National
18h 07m
1 stop
DSM9:17 pmDes Moines
$794

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 16, 2026.
Use the filters below to find and compare flights from Des Moines to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Tue 9/29

11:27 am-7:10 am

2 stops12h 43m

Brussels Bruxelles-National

Tue 10/6

9:10 am-11:35 pm

2 stops21h 25m

$769

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Mon 12/7

8:00 am-7:50 am

2 stops16h 50m

Brussels Bruxelles-National

Wed 12/9

10:00 am-10:20 am

2 stops31h 20m

$773

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Mon 12/7

6:15 am-7:50 am

2 stops18h 35m

Brussels Bruxelles-National

Wed 12/9

10:00 am-2:11 pm

2 stops35h 11m

$773

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Mon 12/7

6:15 am-7:50 am

2 stops18h 35m

Brussels Bruxelles-National

Wed 12/9

10:00 am-2:11 pm

2 stops35h 11m

$774

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Thu 12/3

11:30 am-4:15 pm

2 stops21h 45m

Brussels Bruxelles-National

Fri 12/11

10:00 am-2:11 pm

2 stops35h 11m

$778

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Wed 9/30

6:00 am-7:10 am

2 stops18h 10m

Brussels Bruxelles-National

Wed 10/7

9:10 am-11:35 pm

2 stops21h 25m

$778

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Thu 12/3

11:30 am-7:55 pm

2 stops25h 25m

Brussels Bruxelles-National

Fri 12/11

10:00 am-2:11 pm

2 stops35h 11m

$779
Quickest round-trip

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Mon 12/7

1:45 pm-1:15 pm

2 stops16h 30m

Brussels Bruxelles-National

Wed 12/9

10:10 am-7:25 pm

1 stop16h 15m

$787

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Mon 12/7

11:30 am-1:15 pm

2 stops18h 45m

Brussels Bruxelles-National

Wed 12/9

10:10 am-7:25 pm

1 stop16h 15m

$787

Des MoinesBrussels

DSM Des Moines - BRU Brussels Bruxelles-National

DSMBRU

Des Moines

Tue 9/29

3:11 pm-9:00 am

1 stop10h 49m

Brussels Bruxelles-National

Tue 10/6

9:10 am-10:31 am

2 stops32h 21m

$787

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

See travel insights to Brussels from

How to get the cheapest flight ticket from Des Moines to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Brussels Bruxelles-National Airport flights?

You could potentially save up to 7% on your flight if you consider stops on a Des Moines to Brussels Bruxelles-National Airport flight.

When to book flights from Des Moines to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Brussels Bruxelles-National Airport (DSM to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Brussels Bruxelles-National Airport

Fastest flight time

18h 55m

Direct flights

None
The fastest flight from Des Moines to Brussels Bruxelles-National Airport takes 18h 55m
There are no direct flights from Des Moines to Brussels Bruxelles-National Airport. There are no popular flight routes from Des Moines to Brussels Bruxelles-National Airport.
Search flight deals

Frequently asked questions about flying from Des Moines to Brussels Bruxelles-National Airport

  • How far is Des Moines to Brussels Bruxelles-National by plane?

    There are 4374.0 mi between Des Moines and Brussels Bruxelles-National. Flights usually cover this in 18h 55m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

    Prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from Des Moines Airport to Brussels Bruxelles-National Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The travel and health documents required for your trip to Brussels Bruxelles-National Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Brussels Bruxelles-National Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Brussels Bruxelles-National Airport?

Best airlines flying from Des Moines to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Des Moines to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $757Free CancellationRating
7.4
10,105 reviews
Search United Airlines flights

Traveling to a place near Brussels?

Book flights to Brussels if you plan to visit one of these locations
Bruges
Ghent
Leuven
Dinant
Mons
Durbuy
Zaventem
Charleroi
Genk
Aalst
Waterloo
Namur
Knokke-Heist
Spa
Hasselt
Mechelen
Francorchamps
Halle

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Brussels?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Brussels for you.

Can I find flights from Des Moines to Brussels with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Brussels flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Brussels?

Once you have performed a search for Des Moines to Brussels flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Brussels right now. Can momondo alert me if prices change?

Price alerts on flights to Brussels from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Brussels Bruxelles-National Airport trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Tue 9/15
Tue 9/22
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to Brussels

Popular cities in Belgium

Popular flights according to clicks in the last 7 days on momondo
Flights to Charleroi Brussels Airportfrom $610