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Cheap flights from Des Moines to Brussels from $373

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Brussels departing on 9/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Brussels

Cheap round-trip flights

British Airways Logo
6:07 pm - 4:20 pmDSM-BRU
16h 13m2 stops
British Airways Logo
8:45 pm - 10:08 pmBRU-DSM
32h 23m2 stops
$632British Airways
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Wed, Oct 29 - Mon, Nov 10
Scandinavian Airlines Logo
10:52 am - 9:40 amDSM-BRU
39h 48m2 stops
Scandinavian Airlines Logo
3:10 pm - 10:43 pmBRU-DSM
37h 33m2 stops
$660Scandinavian Airlines
Find Deal
Fri, Oct 17 - Sun, Oct 26
Scandinavian Airlines Logo
2:05 pm - 9:40 amDSM-BRU
36h 35m2 stops
Scandinavian Airlines Logo
8:30 pm - 10:37 pmBRU-DSM
33h 07m2 stops
$668Scandinavian Airlines
Find Deal
Fri, Sep 12 - Fri, Sep 19
Air Canada Logo
11:35 am - 8:05 amDSM-BRU
13h 30m2 stops
Air Canada Logo
10:00 am - 9:45 pmBRU-DSM
18h 45m2 stops
$722Air Canada
Find Deal
Sun, Sep 14 - Sun, Sep 21
Air Canada Logo
11:35 am - 8:05 amDSM-BRU
13h 30m2 stops
Air Canada Logo
10:00 am - 9:45 pmBRU-DSM
18h 45m2 stops
$736Air Canada
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Sun, Sep 14 - Sun, Sep 21
United Airlines Logo
8:00 am - 8:05 amDSM-BRU
17h 05m2 stops
United Airlines Logo
10:00 am - 5:14 pmBRU-DSM
38h 14m2 stops
$753United Airlines
Find Deal
Fri, Sep 12 - Fri, Sep 19
United Airlines Logo
1:10 pm - 9:00 amDSM-BRU
12h 50m1 stop
United Airlines Logo
10:00 am - 9:45 pmBRU-DSM
42h 45m3 stops
$754United Airlines
Find Deal
Fri, Sep 12 - Fri, Sep 19
Logo
3:25 pm - 8:05 amDSM-BRU
33h 40m2 stops
Logo
12:45 pm - 9:45 pmBRU-DSM
40h 00m2 stops
$803
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Sat, Sep 13 - Sat, Sep 20
Virgin Atlantic Logo
2:05 pm - 8:40 amDSM-BRU
11h 35m1 stop
Virgin Atlantic Logo
10:45 am - 5:45 pmBRU-DSM
14h 00m1 stop
$806Virgin Atlantic
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Tue, Sep 16 - Sun, Sep 28
Logo
6:25 pm - 8:05 amDSM-BRU
30h 40m2 stops
Logo
12:45 pm - 9:45 pmBRU-DSM
40h 00m2 stops
$807
Find Deal
Sat, Sep 13 - Sat, Sep 20

United Airlines flights from Des Moines to Brussels Bruxelles-National Airport

Our best United Airlines deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
United Airlines
Sep 12
DSM8:00 amDes Moines
17h 05m
2 stops
BRU8:05 amBrussels Bruxelles-National
Sep 19
BRU10:00 amBrussels Bruxelles-National
38h 14m
2 stops
DSM5:14 pmDes Moines
$753
Find similar
United Airlines
Sep 12
DSM1:10 pmDes Moines
12h 50m
1 stop
BRU9:00 amBrussels Bruxelles-National
Sep 19
BRU10:00 amBrussels Bruxelles-National
42h 45m
3 stops
DSM9:45 pmDes Moines
$754
Find similar
United Airlines
Sep 13
DSM11:35 amDes Moines
14h 25m
1 stop
BRU9:00 amBrussels Bruxelles-National
Sep 20
BRU12:00 pmBrussels Bruxelles-National
16h 45m
2 stops
DSM9:45 pmDes Moines
$761
Find similar

Scandinavian Airlines flights from Des Moines to Brussels Bruxelles-National Airport

Our best Scandinavian Airlines deals on Des Moines to Brussels Bruxelles-National Airport flight tickets
Scandinavian Airlines
Oct 17
DSM10:52 amDes Moines
39h 48m
2 stops
BRU9:40 amBrussels Bruxelles-National
Oct 26
BRU3:10 pmBrussels Bruxelles-National
37h 33m
2 stops
DSM10:43 pmDes Moines
$660
Find similar
Scandinavian Airlines
Sep 12
DSM2:05 pmDes Moines
36h 35m
2 stops
BRU9:40 amBrussels Bruxelles-National
Sep 19
BRU8:30 pmBrussels Bruxelles-National
33h 07m
2 stops
DSM10:37 pmDes Moines
$668
Find similar
Scandinavian Airlines
Sep 12
DSM2:05 pmDes Moines
36h 35m
2 stops
BRU9:40 amBrussels Bruxelles-National
Sep 19
BRU8:30 pmBrussels Bruxelles-National
33h 07m
2 stops
DSM10:37 pmDes Moines
$669
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Brussels Bruxelles-National Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Des Moines to Brussels Bruxelles-National Airport that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Wed 10/29

6:07 pm-4:20 pm

2 stops16h 13m

Brussels Bruxelles-National

Mon 11/10

8:45 pm-10:08 pm

2 stops32h 23m

$632

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 10/17

10:52 am-9:40 am

2 stops39h 48m

Brussels Bruxelles-National

Sun 10/26

3:10 pm-10:43 pm

2 stops37h 33m

$660

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 9/12

2:05 pm-9:40 am

2 stops36h 35m

Brussels Bruxelles-National

Fri 9/19

8:30 pm-10:37 pm

2 stops33h 07m

$668

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sun 9/14

11:35 am-8:05 am

2 stops13h 30m

Brussels Bruxelles-National

Sun 9/21

10:00 am-9:45 pm

2 stops18h 45m

$722

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sun 9/14

11:35 am-8:05 am

2 stops13h 30m

Brussels Bruxelles-National

Sun 9/21

10:00 am-9:45 pm

2 stops18h 45m

$736

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 9/12

8:00 am-8:05 am

2 stops17h 05m

Brussels Bruxelles-National

Fri 9/19

10:00 am-5:14 pm

2 stops38h 14m

$753

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Fri 9/12

1:10 pm-9:00 am

1 stop12h 50m

Brussels Bruxelles-National

Fri 9/19

10:00 am-9:45 pm

3 stops42h 45m

$754

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 9/13

3:25 pm-8:05 am

2 stops33h 40m

Brussels Bruxelles-National

Sat 9/20

12:45 pm-9:45 pm

2 stops40h 00m

$803

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Tue 9/16

2:05 pm-8:40 am

1 stop11h 35m

Brussels Bruxelles-National

Sun 9/28

10:45 am-5:45 pm

1 stop14h 00m

$806

Des MoinesBrussels

DSM - BRU

DSMBRU

Des Moines

Sat 9/13

6:25 pm-8:05 am

2 stops30h 40m

Brussels Bruxelles-National

Sat 9/20

12:45 pm-9:45 pm

2 stops40h 00m

$807

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Brussels from

How to get the cheapest flight ticket from Des Moines to Brussels Bruxelles-National Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Brussels Bruxelles-National Airport?

The cheapest day to depart from Des Moines to Brussels Bruxelles-National Airport is on a Wednesday. Travelers who choose to depart for Brussels Bruxelles-National Airport on a Wednesday will often find tickets for as low as $864. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to Brussels Bruxelles-National Airport for around $1,370.

What is the cheapest time of day to depart on your flight to Brussels Bruxelles-National Airport?

Our most recent data shows that the best time of day to fly to Brussels Bruxelles-National Airport is in the morning. Flights from Des Moines to Brussels Bruxelles-National Airport during this time can be as low as $852. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $932 on average. Flights to Brussels Bruxelles-National Airport from Des Moines in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

When to book flights from Des Moines to Brussels Bruxelles-National Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Brussels Bruxelles-National Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Brussels Bruxelles-National Airport (DSM to BRU) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Brussels Bruxelles-National Airport

Best Price Found

$373

Fastest flight time

10h 35m

Direct flights

None
The best one-way flight to Brussels Bruxelles-National Airport from Des Moines in the past 72 hours is $373. The best round-trip flight deal from Des Moines to Brussels Bruxelles-National Airport found on momondo in the last 72 hours is $632.
The fastest flight from Des Moines to Brussels Bruxelles-National Airport takes 10h 35m
There are no direct flights from Des Moines to Brussels Bruxelles-National Airport. Popular non-direct route for this connection is Des Moines Airport - Brussels Bruxelles-National Airport.
Search flight deals

  • How far is Des Moines to Brussels Bruxelles-National by plane?

    There are 4374.0 mi between Des Moines and Brussels Bruxelles-National. Flights usually cover this in 10h 35m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

    Prices for flights from Des Moines Airport to Brussels Bruxelles-National Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Brussels Bruxelles-National Airport?

  • How old do you have to be to fly from Des Moines Airport to Brussels Bruxelles-National Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Brussels Bruxelles-National Airport.

  • What documentation or ID do you need to fly to Brussels Bruxelles-National Airport?

    The travel and health documents required for your trip to Brussels Bruxelles-National Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Brussels Bruxelles-National Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Brussels Bruxelles-National Airport?

Best airlines flying from Des Moines to Brussels Bruxelles-National Airport

Compare and see reviews for airlines that fly from Des Moines to Brussels Bruxelles-National Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $794Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights

Traveling to a place near Brussels?

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Genk
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Mechelen
Knokke-Heist
Tournai
Durbuy
Oostkamp

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Brussels?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Brussels for you.

Can I find flights from Des Moines to Brussels with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Brussels flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Brussels?

Once you have performed a search for Des Moines to Brussels flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Brussels right now. Can momondo alert me if prices change?

Price alerts on flights to Brussels from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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