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Cheap flights from Denver to Santiago from $249

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Denver to Santiago departing on 1/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Copa Airlines Logo
10:38 pm - 7:20 pmDEN-SCL
18h 42m1 stop
Copa Airlines Logo
4:20 am - 6:16 pmSCL-DEN
15h 56m1 stop
$532Copa Airlines
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Mon, Apr 27 - Mon, May 4
LATAM Airlines Logo
7:05 am - 5:35 amDEN-SCL
19h 30m2 stops
LATAM Airlines Logo
6:40 am - 11:54 pmSCL-DEN
20h 14m2 stops
$538LATAM Airlines
Find Deal
Wed, Mar 11 - Tue, Mar 17
Delta Logo
12:59 am - 7:00 amDEN-SCL
27h 01m1 stop
Delta Logo
8:20 am - 11:54 pmSCL-DEN
18h 34m2 stops
$549Delta
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Tue, Mar 10 - Tue, Mar 17
United Airlines Logo
7:45 am - 8:50 amDEN-SCL
21h 05m1 stop
United Airlines Logo
9:45 pm - 6:40 amSCL-DEN
35h 55m1 stop
$552United Airlines
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Sun, Mar 1 - Sun, Mar 8
Delta Logo
12:59 am - 7:00 amDEN-SCL
27h 01m1 stop
Delta Logo
11:05 pm - 6:10 pmSCL-DEN
21h 05m2 stops
$554Delta
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Sun, Mar 22 - Mon, Apr 6
United Airlines Logo
5:25 pm - 8:50 amDEN-SCL
35h 25m1 stop
United Airlines Logo
9:45 pm - 6:40 amSCL-DEN
35h 55m1 stop
$560United Airlines
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Sat, Feb 28 - Sun, Mar 8
Multiple Airlines Logo
12:59 am - 7:00 amDEN-SCL
27h 01m1 stop
Multiple Airlines Logo
11:00 am - 12:08 pmSCL-DEN
28h 08m1 stop
$563Multiple Airlines
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Mon, Mar 23 - Tue, Mar 31
Multiple Airlines Logo
11:14 pm - 10:15 pmDEN-SCL
19h 01m2 stops
Multiple Airlines Logo
10:35 am - 9:08 amSCL-DEN
26h 33m1 stop
$583Multiple Airlines
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Mon, Nov 24 - Wed, Dec 3
American Airlines Logo
10:45 am - 8:15 amDEN-SCL
17h 30m1 stop
American Airlines Logo
11:55 pm - 4:01 pmSCL-DEN
20h 06m2 stops
$659American Airlines
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Mon, Feb 9 - Mon, Feb 23
American Airlines Logo
9:17 am - 7:50 amDEN-SCL
18h 33m1 stop
American Airlines Logo
9:15 pm - 9:57 amSCL-DEN
16h 42m1 stop
$684American Airlines
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Mon, Feb 23 - Sat, Mar 7

Copa Airlines flights from Denver to Santiago

Our best Copa Airlines deals on Denver to Santiago flight tickets
Copa Airlines
Apr 27
DEN10:38 pmDenver Intl
18h 42m
1 stop
SCL7:20 pmSantiago Arturo Merino Benitez
May 4
SCL4:20 amSantiago Arturo Merino Benitez
15h 56m
1 stop
DEN6:16 pmDenver Intl
$532
Find similar
Copa Airlines
Mar 23
DEN10:48 pmDenver Intl
22h 46m
1 stop
SCL12:34 amSantiago Arturo Merino Benitez
Apr 6
SCL4:44 amSantiago Arturo Merino Benitez
15h 32m
1 stop
DEN6:16 pmDenver Intl
$587
Find similar
Copa Airlines
Apr 27
DEN10:38 pmDenver Intl
22h 05m
1 stop
SCL10:43 pmSantiago Arturo Merino Benitez
May 3
SCL12:16 amSantiago Arturo Merino Benitez
20h 00m
1 stop
DEN6:16 pmDenver Intl
$607
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LATAM Airlines flights from Denver to Santiago

Our best LATAM Airlines deals on Denver to Santiago flight tickets
LATAM Airlines
Mar 11
DEN7:05 amDenver Intl
19h 30m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
Mar 17
SCL6:40 amSantiago Arturo Merino Benitez
20h 14m
2 stops
DEN11:54 pmDenver Intl
$538
Find similar
LATAM Airlines
Mar 4
DEN12:59 amDenver Intl
25h 36m
2 stops
SCL6:35 amSantiago Arturo Merino Benitez
Mar 8
SCL11:55 pmSantiago Arturo Merino Benitez
21h 14m
1 stop
DEN6:09 pmDenver Intl
$544
Find similar
LATAM Airlines
Apr 2
DEN3:10 pmDenver Intl
13h 50m
1 stop
SCL8:00 amSantiago Arturo Merino Benitez
Apr 12
SCL7:40 pmSantiago Arturo Merino Benitez
30h 11m
2 stops
DEN11:51 pmDenver Intl
$569
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momondo Fare Finder

 
Customize your flight search to find flights from Denver to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Denver to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 4/27

10:38 pm-7:20 pm

1 stop18h 42m

Santiago Arturo Merino Benitez

Mon 5/4

4:20 am-6:16 pm

1 stop15h 56m

$532

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Wed 3/11

7:05 am-5:35 am

2 stops19h 30m

Santiago Arturo Merino Benitez

Tue 3/17

6:40 am-11:54 pm

2 stops20h 14m

$538

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 3/10

12:59 am-7:00 am

1 stop27h 01m

Santiago Arturo Merino Benitez

Tue 3/17

8:20 am-11:54 pm

2 stops18h 34m

$549

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 3/1

7:45 am-8:50 am

1 stop21h 05m

Santiago Arturo Merino Benitez

Sun 3/8

9:45 pm-6:40 am

1 stop35h 55m

$552

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 3/22

12:59 am-7:00 am

1 stop27h 01m

Santiago Arturo Merino Benitez

Mon 4/6

11:05 pm-6:10 pm

2 stops21h 05m

$554

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sat 2/28

5:25 pm-8:50 am

1 stop35h 25m

Santiago Arturo Merino Benitez

Sun 3/8

9:45 pm-6:40 am

1 stop35h 55m

$560

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 3/23

12:59 am-7:00 am

1 stop27h 01m

Santiago Arturo Merino Benitez

Tue 3/31

11:00 am-12:08 pm

1 stop28h 08m

$563

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 11/24

11:14 pm-10:15 pm

2 stops19h 01m

Santiago Arturo Merino Benitez

Wed 12/3

10:35 am-9:08 am

1 stop26h 33m

$583

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 2/9

10:45 am-8:15 am

1 stop17h 30m

Santiago Arturo Merino Benitez

Mon 2/23

11:55 pm-4:01 pm

2 stops20h 06m

$659

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 2/23

9:17 am-7:50 am

1 stop18h 33m

Santiago Arturo Merino Benitez

Sat 3/7

9:15 pm-9:57 am

1 stop16h 42m

$684

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Denver to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Denver and Santiago?

What is the cheapest month to fly to Santiago?

In general, September is the cheapest month to fly from Denver to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $681. If you don’t want to visit Santiago in September, then you should wait until April to fly from Denver, when ticket prices are also cheap, with an average price of $752.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Tuesday when prices can be found for as low as $798. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $1,032.

What is the cheapest time of day to depart on your flight to Santiago?

In the afternoon is the cheapest time of day to fly from Denver to Santiago when you can find flight prices for as low as $827. Flying to Santiago in the afternoon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $985 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $841 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Denver for as low as $746 on momondo.

When to book flights from Denver to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Denver to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Denver to Santiago (DEN to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to Santiago

Direct flights

None
There are no direct flights from Denver to Santiago. There are no popular flight routes from Denver to Santiago.
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  • How far is Denver Intl to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Denver Intl to Santiago Arturo Merino Benitez is 5508.2 mi. 12h 20m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Denver Intl Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Denver Intl Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from Denver Intl Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Denver Intl Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Denver Intl Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Denver to Santiago?

Best airlines flying from Denver to Santiago

Compare and see reviews for airlines that fly from Denver to Santiago with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $551Free CancellationRating
7.4
8,999 reviews
Search United Airlines flights
LATAM AirlinesPriceFrom $563Free CancellationRating
7.5
1,873 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $575Free CancellationRating
7.6
1,561 reviews
Search Copa Airlines flights
DeltaPriceFrom $623Free CancellationRating
7.9
8,002 reviews
Search Delta flights
American AirlinesPriceFrom $632Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights
AeromexicoPriceFrom $823Free CancellationRating
7.4
1,672 reviews
Search Aeromexico flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Denver to Santiago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Denver to Santiago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Denver to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from Denver which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Denver to Santiago?

momondo helps you find the best flight between Denver and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Denver to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Denver to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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