Cheap flights from Denver to Santiago from $306

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Denver to Santiago departing on 5/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.

Find the cheapest flights from Denver to Santiago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:05 pm - 5:30 am
DEN
-
SCL
28h 25m
2 stops
Multiple Airlines Logo
8:20 pm - 12:14 pm
SCL
-
DEN
41h 54m
3 stops
$665Multiple Airlines
Tue, Apr 21 - Tue, Apr 28
Multiple Airlines Logo
7:05 pm - 5:30 am
DEN
-
SCL
32h 25m
3 stops
Multiple Airlines Logo
8:20 pm - 12:14 pm
SCL
-
DEN
41h 54m
3 stops
$666Multiple Airlines
Tue, Apr 21 - Tue, Apr 28
Multiple Airlines Logo
11:05 pm - 5:30 am
DEN
-
SCL
28h 25m
2 stops
Multiple Airlines Logo
12:55 am - 9:40 am
SCL
-
DEN
34h 45m
2 stops
$671Multiple Airlines
Tue, Apr 21 - Mon, Apr 27
LATAM Airlines Logo
7:25 am - 5:35 am
DEN
-
SCL
20h 10m
1 stop
LATAM Airlines Logo
11:25 pm - 6:18 pm
SCL
-
DEN
20h 53m
1 stop
$673LATAM Airlines
Wed, Jun 24 - Wed, Jul 8
Multiple Airlines Logo
6:00 am - 5:30 am
DEN
-
SCL
45h 30m
3 stops
Multiple Airlines Logo
5:00 am - 12:18 am
SCL
-
DEN
45h 18m
3 stops
$688Multiple Airlines
Mon, Jun 1 - Fri, Jun 5
LATAM Airlines Logo
6:30 am - 5:35 am
DEN
-
SCL
21h 05m
1 stop
LATAM Airlines Logo
11:25 pm - 6:10 pm
SCL
-
DEN
21h 45m
1 stop
$689LATAM Airlines
Tue, Sep 1 - Mon, Sep 28
LATAM Airlines Logo
6:30 am - 5:35 am
DEN
-
SCL
21h 05m
1 stop
LATAM Airlines Logo
11:25 pm - 6:10 pm
SCL
-
DEN
21h 45m
1 stop
$693LATAM Airlines
Tue, Sep 1 - Mon, Sep 28
LATAM Airlines Logo
10:58 am - 5:35 am
DEN
-
SCL
16h 37m
2 stops
LATAM Airlines Logo
11:25 pm - 6:18 pm
SCL
-
DEN
20h 53m
1 stop
$694LATAM Airlines
Wed, Jun 24 - Wed, Jul 8
Multiple Airlines Logo
11:40 pm - 5:30 am
DEN
-
SCL
27h 50m
2 stops
Multiple Airlines Logo
5:00 am - 12:18 am
SCL
-
DEN
45h 18m
3 stops
$695Multiple Airlines
Mon, Jun 1 - Fri, Jun 5
LATAM Airlines Logo
12:29 pm - 5:35 am
DEN
-
SCL
15h 06m
1 stop
LATAM Airlines Logo
11:00 pm - 5:56 pm
SCL
-
DEN
20h 56m
2 stops
$700LATAM Airlines
Mon, Jul 13 - Sun, Jul 26

American Airlines flights from Denver to Santiago

Our best American Airlines deals on Denver to Santiago flight tickets
American Airlines
Aug 4
DEN12:13 pmDenver Intl
16h 37m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
Aug 16
SCL8:30 pmSantiago Arturo Merino Benitez
17h 42m
1 stop
DEN12:12 pmDenver Intl
$735
American Airlines
Aug 5
DEN11:52 pmDenver Intl
28h 58m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
Aug 12
SCL8:30 pmSantiago Arturo Merino Benitez
28h 08m
1 stop
DEN10:38 pmDenver Intl
$736
American Airlines
Aug 5
DEN7:20 amDenver Intl
21h 30m
2 stops
SCL6:50 amSantiago Arturo Merino Benitez
Aug 12
SCL8:30 pmSantiago Arturo Merino Benitez
17h 42m
1 stop
DEN12:12 pmDenver Intl
$738

Delta flights from Denver to Santiago

Our best Delta deals on Denver to Santiago flight tickets
Delta
Aug 4
DEN7:15 amDenver Intl
20h 20m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
Aug 16
SCL11:25 pmSantiago Arturo Merino Benitez
21h 45m
2 stops
DEN7:10 pmDenver Intl
$740
Delta
Jul 13
DEN10:25 amDenver Intl
18h 30m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
Jul 25
SCL11:25 pmSantiago Arturo Merino Benitez
20h 53m
1 stop
DEN6:18 pmDenver Intl
$780

momondo Fare Finder

 
Customize your flight search to find flights from Denver to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 27, 2026.
Use the filters below to find and compare flights from Denver to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 4/21

11:05 pm-5:30 am

2 stops28h 25m

Santiago Arturo Merino Benitez

Tue 4/28

8:20 pm-12:14 pm

3 stops41h 54m

$665

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 4/21

7:05 pm-5:30 am

3 stops32h 25m

Santiago Arturo Merino Benitez

Tue 4/28

8:20 pm-12:14 pm

3 stops41h 54m

$666

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 4/21

11:05 pm-5:30 am

2 stops28h 25m

Santiago Arturo Merino Benitez

Mon 4/27

12:55 am-9:40 am

2 stops34h 45m

$671

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Wed 6/24

7:25 am-5:35 am

1 stop20h 10m

Santiago Arturo Merino Benitez

Wed 7/8

11:25 pm-6:18 pm

1 stop20h 53m

$673

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 6/1

6:00 am-5:30 am

3 stops45h 30m

Santiago Arturo Merino Benitez

Fri 6/5

5:00 am-12:18 am

3 stops45h 18m

$688

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 9/1

6:30 am-5:35 am

1 stop21h 05m

Santiago Arturo Merino Benitez

Mon 9/28

11:25 pm-6:10 pm

1 stop21h 45m

$689

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 9/1

6:30 am-5:35 am

1 stop21h 05m

Santiago Arturo Merino Benitez

Mon 9/28

11:25 pm-6:10 pm

1 stop21h 45m

$693

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Wed 6/24

10:58 am-5:35 am

2 stops16h 37m

Santiago Arturo Merino Benitez

Wed 7/8

11:25 pm-6:18 pm

1 stop20h 53m

$694

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 6/1

11:40 pm-5:30 am

2 stops27h 50m

Santiago Arturo Merino Benitez

Fri 6/5

5:00 am-12:18 am

3 stops45h 18m

$695
Quickest round-trip

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 7/13

12:29 pm-5:35 am

1 stop15h 06m

Santiago Arturo Merino Benitez

Sun 7/26

11:00 pm-5:56 pm

2 stops20h 56m

$700

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Santiago from

How to get the cheapest flight ticket from Denver to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Denver and Santiago?

What is the cheapest month to fly to Santiago?

In general, September is the cheapest month to fly from Denver to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $663. If you don’t want to visit Santiago in September, then you should wait until October to fly from Denver, when ticket prices are also cheap, with an average price of $681.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $799 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Denver for as low as $618 on momondo.

Can stopping save me money on Denver to Santiago flights?

You could potentially save up to 1% on your flight if you consider stops on a Denver to Santiago flight.

How have Denver to Santiago flight prices changed over time?

As of March 2026, prices for Denver to Santiago flights are approximately 6% cheaper when compared to flights at the same time last year.

When to book flights from Denver to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Denver to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Denver to Santiago (DEN to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to Santiago

Fastest flight time

17h 55m

Direct flights

None
The fastest flight from Denver to Santiago takes 17h 55m
There are no direct flights from Denver to Santiago. There are no popular flight routes from Denver to Santiago.
  • How far is Denver Intl to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Denver Intl to Santiago Arturo Merino Benitez is 5508.2 mi. 17h 55m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Denver Intl Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Denver Intl Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from Denver Intl Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Denver Intl Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Denver Intl Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Denver to Santiago?

Best airlines flying from Denver to Santiago

Compare and see reviews for airlines that fly from Denver to Santiago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $369Free CancellationRating
7.5
1,579 reviews
Search Copa Airlines flights
LATAM AirlinesPriceFrom $537Free CancellationRating
7.4
1,902 reviews
Search LATAM Airlines flights
DeltaPriceFrom $544Free CancellationRating
7.9
8,353 reviews
Search Delta flights
United AirlinesPriceFrom $551Free CancellationRating
7.4
9,500 reviews
Search United Airlines flights
American AirlinesPriceFrom $590Free CancellationRating
7.1
11,519 reviews
Search American Airlines flights
AeromexicoPriceFrom $744Free CancellationRating
7.4
1,557 reviews
Search Aeromexico flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Valparaíso
Santa Cruz
Valle Nevado
San Fernando
Pichilemu
Zapallar

Why use momondo?

Why should I use momondo to find a flight deal from Denver to Santiago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Denver to Santiago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Denver to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from Denver which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Denver to Santiago?

momondo helps you find the best flight between Denver and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Denver to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Denver to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Santiago trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sun 4/26
Sun 5/3

Find better results for your trip to Chile