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Cheap flights from Denver to Santiago from $310

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Denver to Santiago departing on 10/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Denver to Santiago (DEN-SCL)

Cheap round-trip flights

Copa Airlines Logo
9:36 pm - 12:06 amDEN-SCL
22h 30m1 stop
Copa Airlines Logo
12:20 pm - 5:17 pmSCL-DEN
32h 57m1 stop
$555Copa Airlines
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Sun, Nov 23 - Sat, Nov 29
United Airlines Logo
7:15 pm - 8:50 amDEN-SCL
33h 35m1 stop
United Airlines Logo
10:45 pm - 2:15 pmSCL-DEN
19h 30m1 stop
$562United Airlines
Find Deal
Thu, Jan 29 - Tue, Feb 17
American Airlines Logo
5:00 am - 7:50 amDEN-SCL
22h 50m1 stop
American Airlines Logo
10:15 pm - 6:09 pmSCL-DEN
23h 54m1 stop
$564American Airlines
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Mon, Feb 9 - Mon, Feb 23
LATAM Airlines Logo
7:05 am - 7:00 amDEN-SCL
19h 55m1 stop
LATAM Airlines Logo
8:20 am - 10:49 pmSCL-DEN
18h 29m2 stops
$567LATAM Airlines
Find Deal
Thu, Jan 29 - Tue, Feb 17
American Airlines Logo
5:00 am - 7:50 amDEN-SCL
22h 50m1 stop
American Airlines Logo
11:55 pm - 3:48 pmSCL-DEN
19h 53m2 stops
$568American Airlines
Find Deal
Mon, Feb 9 - Mon, Feb 23
LATAM Airlines Logo
1:35 pm - 5:20 pmDEN-SCL
23h 45m2 stops
LATAM Airlines Logo
4:35 am - 10:49 pmSCL-DEN
22h 14m2 stops
$574LATAM Airlines
Find Deal
Tue, Feb 10 - Wed, Feb 25
Delta Logo
6:05 am - 7:00 amDEN-SCL
20h 55m1 stop
Delta Logo
11:15 pm - 9:44 pmSCL-DEN
26h 29m1 stop
$614Delta
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Wed, Dec 3 - Sun, Dec 21
Logo
6:00 pm - 6:55 amDEN-SCL
32h 55m1 stop
Logo
10:15 pm - 11:54 pmSCL-DEN
29h 39m2 stops
$627
Find Deal
Thu, Jan 15 - Sun, Jan 25
Delta Logo
12:00 pm - 7:00 amDEN-SCL
15h 00m1 stop
Delta Logo
11:15 pm - 2:02 pmSCL-DEN
18h 47m1 stop
$654Delta
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Wed, Nov 12 - Mon, Dec 15
Logo
6:55 pm - 6:00 amDEN-SCL
32h 05m2 stops
Logo
10:55 pm - 8:33 amSCL-DEN
36h 38m1 stop
$675
Find Deal
Sat, Oct 4 - Sat, Oct 11

American Airlines flights from Denver to Santiago

Our best American Airlines deals on Denver to Santiago flight tickets
American Airlines
Feb 9
DEN5:00 amDenver Intl
22h 50m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Feb 23
SCL10:15 pmSantiago Arturo Merino Benitez
23h 54m
1 stop
DEN6:09 pmDenver Intl
$564
Find similar
American Airlines
Feb 9
DEN5:00 amDenver Intl
22h 50m
1 stop
SCL7:50 amSantiago Arturo Merino Benitez
Feb 23
SCL11:55 pmSantiago Arturo Merino Benitez
19h 53m
2 stops
DEN3:48 pmDenver Intl
$568
Find similar
American Airlines
Nov 11
DEN8:50 amDenver Intl
20h 15m
1 stop
SCL9:05 amSantiago Arturo Merino Benitez
Dec 16
SCL10:15 pmSantiago Arturo Merino Benitez
23h 46m
1 stop
DEN6:01 pmDenver Intl
$609
Find similar

United Airlines flights from Denver to Santiago

Our best United Airlines deals on Denver to Santiago flight tickets
United Airlines
Jan 29
DEN7:15 pmDenver Intl
33h 35m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Feb 17
SCL10:45 pmSantiago Arturo Merino Benitez
19h 30m
1 stop
DEN2:15 pmDenver Intl
$562
Find similar
United Airlines
Feb 10
DEN5:00 amDenver Intl
23h 50m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Feb 24
SCL10:45 pmSantiago Arturo Merino Benitez
14h 10m
1 stop
DEN8:55 amDenver Intl
$572
Find similar
United Airlines
Nov 23
DEN5:25 pmDenver Intl
35h 25m
1 stop
SCL8:50 amSantiago Arturo Merino Benitez
Dec 1
SCL10:45 pmSantiago Arturo Merino Benitez
27h 19m
1 stop
DEN10:04 pmDenver Intl
$580
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momondo Fare Finder

 
Customize your flight search to find flights from Denver to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Denver to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sun 11/23

9:36 pm-12:06 am

1 stop22h 30m

Santiago Arturo Merino Benitez

Sat 11/29

12:20 pm-5:17 pm

1 stop32h 57m

$555

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Thu 1/29

7:15 pm-8:50 am

1 stop33h 35m

Santiago Arturo Merino Benitez

Tue 2/17

10:45 pm-2:15 pm

1 stop19h 30m

$562

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 2/9

5:00 am-7:50 am

1 stop22h 50m

Santiago Arturo Merino Benitez

Mon 2/23

10:15 pm-6:09 pm

1 stop23h 54m

$564

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Thu 1/29

7:05 am-7:00 am

1 stop19h 55m

Santiago Arturo Merino Benitez

Tue 2/17

8:20 am-10:49 pm

2 stops18h 29m

$567

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Mon 2/9

5:00 am-7:50 am

1 stop22h 50m

Santiago Arturo Merino Benitez

Mon 2/23

11:55 pm-3:48 pm

2 stops19h 53m

$568

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Tue 2/10

1:35 pm-5:20 pm

2 stops23h 45m

Santiago Arturo Merino Benitez

Wed 2/25

4:35 am-10:49 pm

2 stops22h 14m

$574

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Wed 12/3

6:05 am-7:00 am

1 stop20h 55m

Santiago Arturo Merino Benitez

Sun 12/21

11:15 pm-9:44 pm

1 stop26h 29m

$614

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Thu 1/15

6:00 pm-6:55 am

1 stop32h 55m

Santiago Arturo Merino Benitez

Sun 1/25

10:15 pm-11:54 pm

2 stops29h 39m

$627

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Wed 11/12

12:00 pm-7:00 am

1 stop15h 00m

Santiago Arturo Merino Benitez

Mon 12/15

11:15 pm-2:02 pm

1 stop18h 47m

$654

DenverSantiago

DEN - SCL

DENSCL

Denver Intl

Sat 10/4

6:55 pm-6:00 am

2 stops32h 05m

Santiago Arturo Merino Benitez

Sat 10/11

10:55 pm-8:33 am

1 stop36h 38m

$675

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Denver to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, October is the cheapest month to fly from Denver to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $747. If you don’t want to visit Santiago in October, then you should wait until April to fly from Denver, when ticket prices are also cheap, with an average price of $752.

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart on your flight to Santiago is on a Tuesday when prices can be found for as low as $798. This is often the case because there is less demand to fly during this day of the week. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is $1,032.

What is the cheapest time of day to depart on your flight to Santiago?

In the afternoon is the cheapest time of day to fly from Denver to Santiago when you can find flight prices for as low as $827. Flying to Santiago in the afternoon is an ideal time because this is during off-peak travel hours. In the morning is when there is more demand to fly to Santiago, so prices are often more expensive at around $985 per ticket.

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $847 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Denver for as low as $763 on momondo.

When to book flights from Denver to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Denver to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Denver to Santiago (DEN to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to Santiago

Direct flights

None
There are no direct flights from Denver to Santiago. There are no popular flight routes from Denver to Santiago.
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  • How far is Denver Intl to Santiago Arturo Merino Benitez by plane?

    The straight-line distance from Denver Intl to Santiago Arturo Merino Benitez is 5508.2 mi. 12h 43m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Denver Intl Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Denver Intl Airport to Santiago Arturo Merino Benitez Airport were last updated today.

  • How many operators does momondo search for flights from Denver Intl Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Denver Intl Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Denver Intl Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The required travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santiago Arturo Merino Benitez Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Denver to Santiago?

Best airlines flying from Denver to Santiago

Compare and see reviews for airlines that fly from Denver to Santiago with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $563Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights
LATAM AirlinesPriceFrom $573Free CancellationRating
7.5
1,844 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $608Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
Copa AirlinesPriceFrom $620Free CancellationRating
7.5
1,512 reviews
Search Copa Airlines flights
DeltaPriceFrom $752Free CancellationRating
7.9
7,981 reviews
Search Delta flights
AeromexicoPriceFrom $803Free CancellationRating
7.4
1,716 reviews
Search Aeromexico flights

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Denver to Santiago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Denver to Santiago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Denver to Santiago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santiago from Denver which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Denver to Santiago?

momondo helps you find the best flight between Denver and Santiago by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Denver to Santiago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Denver to Santiago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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