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Cheap flights from Denver to Panama City from $191

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Denver to Panama City departing on 10/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Multiple Airlines Logo
12:34 am - 10:40 amDEN-PTY
9h 06m1 stop
Multiple Airlines Logo
9:33 pm - 8:33 amPTY-DEN
12h 00m1 stop
$483Multiple Airlines
Find Deal
Sat, Oct 18 - Sun, Oct 26
Multiple Airlines Logo
8:21 pm - 7:29 pmDEN-PTY
22h 08m2 stops
Multiple Airlines Logo
9:33 pm - 8:33 amPTY-DEN
12h 00m1 stop
$500Multiple Airlines
Find Deal
Wed, Oct 15 - Wed, Oct 22
Multiple Airlines Logo
6:55 pm - 8:11 amDEN-PTY
12h 16m1 stop
Multiple Airlines Logo
9:33 pm - 8:33 amPTY-DEN
12h 00m1 stop
$513Multiple Airlines
Find Deal
Sun, Oct 5 - Fri, Oct 10
Multiple Airlines Logo
12:59 am - 2:30 pmDEN-PTY
12h 31m2 stops
Multiple Airlines Logo
6:34 pm - 8:33 amPTY-DEN
14h 59m1 stop
$520Multiple Airlines
Find Deal
Sat, Oct 18 - Sun, Oct 26
Copa Airlines Logo
9:38 pm - 5:33 amDEN-PTY
5h 55mnonstop
Copa Airlines Logo
12:56 pm - 5:16 pmPTY-DEN
6h 20mnonstop
$535Copa Airlines
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Sat, Jan 17 - Wed, Jan 28
Delta Logo
6:05 am - 8:04 pmDEN-PTY
11h 59m1 stop
Delta Logo
3:27 pm - 11:54 pmPTY-DEN
10h 27m1 stop
$539Delta
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Fri, Jan 16 - Tue, Jan 27
Copa Airlines Logo
9:36 pm - 5:33 amDEN-PTY
5h 57mnonstop
Copa Airlines Logo
12:56 pm - 5:17 pmPTY-DEN
6h 21mnonstop
$548Copa Airlines
Find Deal
Fri, Nov 14 - Sun, Nov 23
American Airlines Logo
11:59 pm - 1:10 pmDEN-PTY
11h 11m1 stop
American Airlines Logo
2:30 pm - 10:27 pmPTY-DEN
9h 57m1 stop
$549American Airlines
Find Deal
Fri, Feb 20 - Tue, Feb 24
Delta Logo
12:00 pm - 2:02 pmDEN-PTY
24h 02m1 stop
Delta Logo
3:27 pm - 11:54 pmPTY-DEN
10h 27m1 stop
$551Delta
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Thu, Jan 15 - Tue, Jan 27
American Airlines Logo
11:59 pm - 3:00 pmDEN-PTY
13h 01m1 stop
American Airlines Logo
4:40 pm - 9:26 amPTY-DEN
18h 46m2 stops
$554American Airlines
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Wed, Feb 18 - Sat, Feb 28

Copa Airlines flights from Denver to Panama City

Our best Copa Airlines deals on Denver to Panama City flight tickets
Copa Airlines
Jan 17
DEN9:38 pmDenver Intl
5h 55m
PTY5:33 amPanama City Tocumen Intl
Jan 28
PTY12:56 pmPanama City Tocumen Intl
6h 20m
DEN5:16 pmDenver Intl
$535
Find similar
Copa Airlines
Nov 14
DEN9:36 pmDenver Intl
5h 57m
PTY5:33 amPanama City Tocumen Intl
Nov 23
PTY12:56 pmPanama City Tocumen Intl
6h 21m
DEN5:17 pmDenver Intl
$548
Find similar
Copa Airlines
Oct 13
DEN10:46 pmDenver Intl
5h 47m
PTY5:33 amPanama City Tocumen Intl
Oct 20
PTY12:56 pmPanama City Tocumen Intl
6h 11m
DEN6:07 pmDenver Intl
$574
Find similar

Delta flights from Denver to Panama City

Our best Delta deals on Denver to Panama City flight tickets
Delta
Jan 16
DEN6:05 amDenver Intl
11h 59m
1 stop
PTY8:04 pmPanama City Tocumen Intl
Jan 27
PTY3:27 pmPanama City Tocumen Intl
10h 27m
1 stop
DEN11:54 pmDenver Intl
$539
Find similar
Delta
Jan 15
DEN12:00 pmDenver Intl
24h 02m
1 stop
PTY2:02 pmPanama City Tocumen Intl
Jan 27
PTY3:27 pmPanama City Tocumen Intl
10h 27m
1 stop
DEN11:54 pmDenver Intl
$551
Find similar
Delta
Nov 14
DEN6:00 amDenver Intl
11h 59m
1 stop
PTY7:59 pmPanama City Tocumen Intl
Nov 23
PTY8:05 amPanama City Tocumen Intl
16h 59m
1 stop
DEN11:04 pmDenver Intl
$552
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Denver to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Denver to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Sat 10/18

12:34 am-10:40 am

1 stop9h 06m

Panama City Tocumen Intl

Sun 10/26

9:33 pm-8:33 am

1 stop12h 00m

$483

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Wed 10/15

8:21 pm-7:29 pm

2 stops22h 08m

Panama City Tocumen Intl

Wed 10/22

9:33 pm-8:33 am

1 stop12h 00m

$500

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Sun 10/5

6:55 pm-8:11 am

1 stop12h 16m

Panama City Tocumen Intl

Fri 10/10

9:33 pm-8:33 am

1 stop12h 00m

$513

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Sat 10/18

12:59 am-2:30 pm

2 stops12h 31m

Panama City Tocumen Intl

Sun 10/26

6:34 pm-8:33 am

1 stop14h 59m

$520

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Sat 1/17

9:38 pm-5:33 am

Nonstop5h 55m

Panama City Tocumen Intl

Wed 1/28

12:56 pm-5:16 pm

Nonstop6h 20m

$535

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Fri 1/16

6:05 am-8:04 pm

1 stop11h 59m

Panama City Tocumen Intl

Tue 1/27

3:27 pm-11:54 pm

1 stop10h 27m

$539

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Fri 11/14

9:36 pm-5:33 am

Nonstop5h 57m

Panama City Tocumen Intl

Sun 11/23

12:56 pm-5:17 pm

Nonstop6h 21m

$548

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Fri 2/20

11:59 pm-1:10 pm

1 stop11h 11m

Panama City Tocumen Intl

Tue 2/24

2:30 pm-10:27 pm

1 stop9h 57m

$549

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Thu 1/15

12:00 pm-2:02 pm

1 stop24h 02m

Panama City Tocumen Intl

Tue 1/27

3:27 pm-11:54 pm

1 stop10h 27m

$551

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Wed 2/18

11:59 pm-3:00 pm

1 stop13h 01m

Panama City Tocumen Intl

Sat 2/28

4:40 pm-9:26 am

2 stops18h 46m

$554

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Denver to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, October is the cheapest month to fly from Denver to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $527. If you’re not able to fly to Panama City in October, then August is your next best option. Flight prices from Denver to Panama City during August average around $542.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $482. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $630. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Denver to Panama City during this time can be as low as $590. Try not to purchase tickets in the afternoon because they tend to be around $733. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Denver Intl to Panama City Tocumen Intl flight route?

Fly from Denver Intl to Panama City Tocumen Intl for the best Denver Intl - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $645 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Denver for as low as $559 on momondo.

What cabin class options are available on Denver Intl to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Denver Intl to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Denver to Panama City flights?

You could potentially save up to 8% on your flight if you consider stops on a Denver to Panama City flight.

How have Denver to Panama City flight prices changed over time?

As of September 2025, prices for Denver to Panama City flights are approximately 266% more expensive when compared to flights at the same time last year.

When to book flights from Denver to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Denver to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Denver to Panama City (DEN to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to Panama City

Best Price Found

$187

Fastest flight time

5h 45m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Denver in the past 72 hours is $187. The best round-trip flight deal from Denver to Panama City found on momondo in the last 72 hours is $430.
The fastest flight from Denver to Panama City takes 5h 45m
Direct flights go from Denver to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is Denver Intl to Panama City Tocumen Intl by plane?

    Panama City Tocumen Intl is 2639.1 mi away from Denver Intl. Flights usually cover this in 5h 47m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Denver Intl Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Denver Intl Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Denver Intl Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Denver Intl Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Denver Intl Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Denver to Panama City?

  • What is the most popular airline from Denver to Panama City?

Best airlines flying from Denver to Panama City

Compare and see reviews for airlines that fly from Denver to Panama City with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $474Free CancellationRating
7.6
1,531 reviews
Search Copa Airlines flights
DeltaPriceFrom $527Free CancellationRating
7.9
7,957 reviews
Search Delta flights
American AirlinesPriceFrom $527Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $527Free CancellationRating
7.4
8,924 reviews
Search United Airlines flights

  • Copa Airlines Flights From Denver to Panama City

    Copa Airlines is one of the most popular airlines flying from Denver to Panama City, operating 4 flights/week on average for this route. A good Copa Airlines flight deal for Denver to Panama City starts from $474 round-trip, up to an average price of $633. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Denver to Panama City

    Another popular option for Denver to Panama City flights is United Airlines (7.4/10, 8,924 ratings). United Airlines flies from Denver to Panama City around 4 times per week, with deals starting from $527 round-trip and rising to an average price of around $695.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Denver to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Denver to Panama City for you.

Can I find flights from Denver to Panama City with flexible booking policies on momondo?

All flight searches from Denver to Panama City on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Denver to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Denver. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Denver to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Denver and alert you when they change.

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