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Cheap flights from Denver to Panama City from $357

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Denver to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:29 am - 1:26 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
10h 57m1 stop Miami
American Airlines Logo
4:48 pm - 9:48 amPTY  Panama City Tocumen Intl-DEN Denver Intl
19h 00m2 stops Miami Dallas/Fort Worth
$645American Airlines
Sun, Jan 31 - Sat, Feb 13
Copa Airlines Logo
9:55 pm - 5:33 amDEN  Denver Intl-PTY Panama City Tocumen Intl
5h 38mnonstop
Copa Airlines Logo
12:45 pm - 5:04 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
6h 19mnonstop
$649Copa Airlines
Sat, Feb 27 - Fri, Mar 5
Copa Airlines Logo
9:40 pm - 4:15 amDEN  Denver Intl-PTY Panama City Tocumen Intl
5h 35mnonstop
Copa Airlines Logo
12:45 pm - 6:04 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
6h 19mnonstop
$649Copa Airlines
Mon, Mar 15 - Wed, Mar 17
Copa Airlines Logo
9:40 pm - 4:15 amDEN  Denver Intl-PTY Panama City Tocumen Intl
5h 35mnonstop
Copa Airlines Logo
12:45 pm - 6:04 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
6h 19mnonstop
$649Copa Airlines
Mon, Mar 15 - Thu, Mar 18
American Airlines Logo
4:23 pm - 2:13 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
19h 50m2 stops Dallas/Fort Worth Miami
American Airlines Logo
2:41 pm - 11:45 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
11h 04m2 stops Miami Dallas/Fort Worth
$655American Airlines
Wed, Dec 9 - Wed, Dec 23
American Airlines Logo
6:18 pm - 2:13 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
17h 55m2 stops Chicago O'Hare Intl Miami
American Airlines Logo
2:41 pm - 11:54 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
11h 13m1 stop Miami
$655American Airlines
Wed, Dec 9 - Wed, Dec 23
United Airlines Logo
7:40 am - 5:12 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
7h 32m1 stop Houston George Bush Intcntl
United Airlines Logo
8:55 am - 4:26 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
9h 31m1 stop Houston George Bush Intcntl
$664United Airlines
Tue, Feb 2 - Fri, Feb 5
United Airlines Logo
5:00 am - 7:38 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
12h 38m1 stop Houston George Bush Intcntl
United Airlines Logo
8:55 am - 11:28 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
16h 33m1 stop Houston George Bush Intcntl
$664United Airlines
Fri, Feb 19 - Mon, Mar 1
Delta Logo
7:10 am - 9:45 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
12h 35m1 stop Atlanta Hartsfield-Jackson
Delta Logo
8:00 am - 11:17 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
17h 17m1 stop Atlanta Hartsfield-Jackson
$664Delta
Thu, Dec 31 - Fri, Jan 8
Delta Logo
6:00 am - 9:45 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
13h 45m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:29 pm - 11:17 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
9h 48m1 stop Atlanta Hartsfield-Jackson
$664Delta
Fri, Jan 1 - Tue, Jan 12

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American Airlines flights from Denver to Panama City

Our best American Airlines deals on Denver to Panama City flight tickets
American Airlines
Jan 31
DEN12:29 amDenver Intl
10h 57m
1 stop
PTY1:26 pmPanama City Tocumen Intl
Feb 13
PTY4:48 pmPanama City Tocumen Intl
19h 00m
2 stops
DEN9:48 amDenver Intl
$645
American Airlines
Dec 9
DEN6:18 pmDenver Intl
17h 55m
2 stops
PTY2:13 pmPanama City Tocumen Intl
Dec 23
PTY2:41 pmPanama City Tocumen Intl
11h 13m
1 stop
DEN11:54 pmDenver Intl
$655
American Airlines
Feb 19
DEN6:14 pmDenver Intl
19h 44m
2 stops
PTY3:58 pmPanama City Tocumen Intl
Mar 1
PTY2:25 pmPanama City Tocumen Intl
9h 38m
1 stop
DEN10:03 pmDenver Intl
$669

United Airlines flights from Denver to Panama City

Our best United Airlines deals on Denver to Panama City flight tickets
United Airlines
Dec 1
DEN5:00 amDenver Intl
12h 38m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Dec 6
PTY8:55 amPanama City Tocumen Intl
16h 34m
1 stop
DEN11:29 pmDenver Intl
$664
United Airlines
Dec 11
DEN8:30 pmDenver Intl
18h 42m
1 stop
PTY5:12 pmPanama City Tocumen Intl
Dec 18
PTY8:55 amPanama City Tocumen Intl
9h 22m
1 stop
DEN4:17 pmDenver Intl
$676
United Airlines
Dec 15
DEN5:00 amDenver Intl
7h 45m
1 stop
PTY2:45 pmPanama City Tocumen Intl
Dec 23
PTY8:55 amPanama City Tocumen Intl
9h 22m
1 stop
DEN4:17 pmDenver Intl
$725

momondo Fare Finder

 
Use the filters below to find and compare flights from Denver to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Sun 1/31

12:29 am-1:26 pm

1 stop10h 57m

Panama City Tocumen Intl

Sat 2/13

4:48 pm-9:48 am

2 stops19h 00m

$645

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Sat 2/27

9:55 pm-5:33 am

Nonstop5h 38m

Panama City Tocumen Intl

Fri 3/5

12:45 pm-5:04 pm

Nonstop6h 19m

$649
Quickest round-trip

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Mon 3/15

9:40 pm-4:15 am

Nonstop5h 35m

Panama City Tocumen Intl

Wed 3/17

12:45 pm-6:04 pm

Nonstop6h 19m

$649

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Mon 3/15

9:40 pm-4:15 am

Nonstop5h 35m

Panama City Tocumen Intl

Thu 3/18

12:45 pm-6:04 pm

Nonstop6h 19m

$649

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Wed 12/9

4:23 pm-2:13 pm

2 stops19h 50m

Panama City Tocumen Intl

Wed 12/23

2:41 pm-11:45 pm

2 stops11h 04m

$655

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Wed 12/9

6:18 pm-2:13 pm

2 stops17h 55m

Panama City Tocumen Intl

Wed 12/23

2:41 pm-11:54 pm

1 stop11h 13m

$655

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Tue 2/2

7:40 am-5:12 pm

1 stop7h 32m

Panama City Tocumen Intl

Fri 2/5

8:55 am-4:26 pm

1 stop9h 31m

$664

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Fri 2/19

5:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Mon 3/1

8:55 am-11:28 pm

1 stop16h 33m

$664

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Thu 12/31

7:10 am-9:45 pm

1 stop12h 35m

Panama City Tocumen Intl

Fri 1/8

8:00 am-11:17 pm

1 stop17h 17m

$664

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Fri 1/1

6:00 am-9:45 pm

1 stop13h 45m

Panama City Tocumen Intl

Tue 1/12

3:29 pm-11:17 pm

1 stop9h 48m

$664

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Denver to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Denver and Panama City?

Prices are currently low for flights on this route.

Typical prices usually range from $672 to $797.
The lowest price recently found on this route was $645.

What is the cheapest month to fly to Panama City?

In general, May is the cheapest month to fly from Denver to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $602. If you’re not able to fly to Panama City in May, then April is your next best option. Flight prices from Denver to Panama City during April average around $602.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $540. If your travel schedule is flexible, try to avoid departing on a Thursday because tickets tend to average around $665. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest Denver Intl to Panama City Tocumen Intl flight route?

Fly from Denver Intl to Panama City Tocumen Intl for the best Denver Intl - Panama City Tocumen Intl flight prices

How far in advance should I book a flight from Denver to Panama City?

You are more likely to see cheaper flights to Panama City from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $690 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Denver for as low as $541 on momondo.

What cabin class options are available on Denver to Panama City flights?

There are 3 cabin classes available to choose from on Denver to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Denver to Panama City flights?

No. A direct flight is the cheapest option for a flight between Denver to Panama City.

How have Denver to Panama City flight prices changed over time?

As of November 2026, prices for Denver to Panama City flights are approximately 52% more expensive when compared to flights at the same time last year.

When to book flights from Denver to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Denver to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Denver to Panama City (DEN to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to Panama City

Best Price Found

$357

Fastest flight time

5h 35m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Denver in the past 72 hours is $357. The best round-trip flight deal from Denver to Panama City found on momondo in the last 72 hours is $645.
The fastest flight from Denver to Panama City takes 5h 35m
Direct flights go from Denver to Panama City every day.
There is 1 airport in Panama City. From Denver there are direct flights to Panama City Tocumen Intl (PTY).
Search flight deals

Frequently asked questions about flying from Denver to Panama City

  • How far is Denver Intl to Panama City Tocumen Intl by plane?

    Panama City Tocumen Intl is 2639.1 mi away from Denver Intl. Flights usually cover this in 5h 35m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Denver Intl Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Denver Intl Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Denver Intl Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Denver Intl Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Denver Intl Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Denver to Panama City?

  • What is the most popular airline from Denver to Panama City?

Best airlines flying from Denver to Panama City

Compare and see reviews for airlines that fly from Denver to Panama City with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $477Free CancellationRating
7.6
1,555 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $531Free CancellationRating
7.3
10,486 reviews
Search United Airlines flights
American AirlinesPriceFrom $634Free CancellationRating
7.0
12,231 reviews
Search American Airlines flights

  • Copa Airlines Flights From Denver to Panama City

    Copa Airlines is one of the most popular airlines flying from Denver to Panama City, operating 2 flights/week on average for this route. A good Copa Airlines flight deal for Denver to Panama City starts from $477 round-trip, up to an average price of $676. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Denver to Panama City

    Another popular option for Denver to Panama City flights is United Airlines (7.3/10, 10,486 ratings). United Airlines flies from Denver to Panama City around 2 times per week, with deals starting from $531 round-trip and rising to an average price of around $683.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Denver to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Denver to Panama City for you.

Can I find flights from Denver to Panama City with flexible booking policies on momondo?

All flight searches from Denver to Panama City on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Denver to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Denver. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Denver to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Denver and alert you when they change.

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