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Cheap flights from Denver to Panama City from $158

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Denver to Panama City departing on 11/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Multiple Airlines Logo
11:25 pm - 3:55 pmDEN-PTY
14h 30m1 stop
Multiple Airlines Logo
9:33 pm - 9:08 amPTY-DEN
13h 35m1 stop
$488Multiple Airlines
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Mon, Jan 12 - Mon, Jan 19
Multiple Airlines Logo
11:25 pm - 3:55 pmDEN-PTY
14h 30m1 stop
Multiple Airlines Logo
5:50 pm - 9:08 amPTY-DEN
17h 18m2 stops
$504Multiple Airlines
Find Deal
Mon, Jan 12 - Mon, Jan 19
Multiple Airlines Logo
12:34 am - 1:00 amDEN-PTY
22h 26m2 stops
Multiple Airlines Logo
1:15 pm - 10:35 amPTY-DEN
23h 20m1 stop
$511Multiple Airlines
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Wed, Nov 12 - Mon, Nov 17
Multiple Airlines Logo
12:34 am - 1:00 amDEN-PTY
22h 26m2 stops
Multiple Airlines Logo
1:15 pm - 10:27 amPTY-DEN
23h 12m1 stop
$512Multiple Airlines
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Wed, Nov 12 - Wed, Nov 19
Copa Airlines Logo
10:19 pm - 6:10 amDEN-PTY
5h 51mnonstop
Copa Airlines Logo
12:56 pm - 5:16 pmPTY-DEN
6h 20mnonstop
$535Copa Airlines
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Fri, Feb 20 - Tue, Feb 24
Copa Airlines Logo
9:38 pm - 5:33 amDEN-PTY
5h 55mnonstop
Copa Airlines Logo
12:56 pm - 5:16 pmPTY-DEN
6h 20mnonstop
$548Copa Airlines
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Fri, Jan 9 - Sun, Jan 18
United Airlines Logo
7:45 am - 7:38 pmDEN-PTY
9h 53m1 stop
United Airlines Logo
8:55 am - 6:16 pmPTY-DEN
11h 21m1 stop
$550United Airlines
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Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
6:54 pm - 1:10 pmDEN-PTY
16h 16m2 stops
American Airlines Logo
2:30 pm - 10:27 pmPTY-DEN
9h 57m1 stop
$554American Airlines
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Fri, Feb 20 - Wed, Feb 25
American Airlines Logo
11:59 pm - 3:38 pmDEN-PTY
13h 39m1 stop
American Airlines Logo
2:27 pm - 11:49 pmPTY-DEN
11h 22m1 stop
$557American Airlines
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Sat, Jan 17 - Wed, Jan 28
United Airlines Logo
7:45 am - 7:38 pmDEN-PTY
9h 53m1 stop
United Airlines Logo
4:41 pm - 11:41 pmPTY-DEN
9h 00m1 stop
$563United Airlines
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Fri, Jan 9 - Sun, Jan 18

American Airlines flights from Denver to Panama City

Our best American Airlines deals on Denver to Panama City flight tickets
American Airlines
Feb 20
DEN6:54 pmDenver Intl
16h 16m
2 stops
PTY1:10 pmPanama City Tocumen Intl
Feb 25
PTY2:30 pmPanama City Tocumen Intl
9h 57m
1 stop
DEN10:27 pmDenver Intl
$554
Find similar
American Airlines
Jan 17
DEN11:59 pmDenver Intl
13h 39m
1 stop
PTY3:38 pmPanama City Tocumen Intl
Jan 28
PTY2:27 pmPanama City Tocumen Intl
11h 22m
1 stop
DEN11:49 pmDenver Intl
$557
Find similar
American Airlines
Feb 28
DEN4:54 pmDenver Intl
20h 06m
2 stops
PTY3:00 pmPanama City Tocumen Intl
Mar 8
PTY1:50 pmPanama City Tocumen Intl
20h 59m
2 stops
DEN9:49 amDenver Intl
$559
Find similar

United Airlines flights from Denver to Panama City

Our best United Airlines deals on Denver to Panama City flight tickets
United Airlines
Feb 20
DEN7:45 amDenver Intl
9h 53m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Feb 24
PTY8:55 amPanama City Tocumen Intl
11h 21m
1 stop
DEN6:16 pmDenver Intl
$550
Find similar
United Airlines
Jan 9
DEN7:45 amDenver Intl
9h 53m
1 stop
PTY7:38 pmPanama City Tocumen Intl
Jan 18
PTY4:41 pmPanama City Tocumen Intl
9h 00m
1 stop
DEN11:41 pmDenver Intl
$563
Find similar
United Airlines
Nov 19
DEN6:00 amDenver Intl
10h 49m
1 stop
PTY6:49 pmPanama City Tocumen Intl
Apr 16
PTY10:00 amPanama City Tocumen Intl
14h 27m
1 stop
DEN11:27 pmDenver Intl
$576
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Denver to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from Denver to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Mon 1/12

11:25 pm-3:55 pm

1 stop14h 30m

Panama City Tocumen Intl

Mon 1/19

9:33 pm-9:08 am

1 stop13h 35m

$488

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Mon 1/12

11:25 pm-3:55 pm

1 stop14h 30m

Panama City Tocumen Intl

Mon 1/19

5:50 pm-9:08 am

2 stops17h 18m

$504

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Wed 11/12

12:34 am-1:00 am

2 stops22h 26m

Panama City Tocumen Intl

Mon 11/17

1:15 pm-10:35 am

1 stop23h 20m

$511

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Wed 11/12

12:34 am-1:00 am

2 stops22h 26m

Panama City Tocumen Intl

Wed 11/19

1:15 pm-10:27 am

1 stop23h 12m

$512

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Fri 2/20

10:19 pm-6:10 am

Nonstop5h 51m

Panama City Tocumen Intl

Tue 2/24

12:56 pm-5:16 pm

Nonstop6h 20m

$535

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Fri 1/9

9:38 pm-5:33 am

Nonstop5h 55m

Panama City Tocumen Intl

Sun 1/18

12:56 pm-5:16 pm

Nonstop6h 20m

$548

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Fri 2/20

7:45 am-7:38 pm

1 stop9h 53m

Panama City Tocumen Intl

Tue 2/24

8:55 am-6:16 pm

1 stop11h 21m

$550

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Fri 2/20

6:54 pm-1:10 pm

2 stops16h 16m

Panama City Tocumen Intl

Wed 2/25

2:30 pm-10:27 pm

1 stop9h 57m

$554

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Sat 1/17

11:59 pm-3:38 pm

1 stop13h 39m

Panama City Tocumen Intl

Wed 1/28

2:27 pm-11:49 pm

1 stop11h 22m

$557

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Fri 1/9

7:45 am-7:38 pm

1 stop9h 53m

Panama City Tocumen Intl

Sun 1/18

4:41 pm-11:41 pm

1 stop9h 00m

$563

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Denver to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, August is the cheapest month to fly from Denver to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $542. If you’re not able to fly to Panama City in August, then October is your next best option. Flight prices from Denver to Panama City during October average around $586.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $483. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $635. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Denver to Panama City during this time can be as low as $592. Try not to purchase tickets in the afternoon because they tend to be around $733. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Denver Intl to Panama City Tocumen Intl flight route?

Fly from Denver Intl to Panama City Tocumen Intl for the best Denver Intl - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $647 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Denver for as low as $578 on momondo.

What cabin class options are available on Denver Intl to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Denver Intl to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Denver to Panama City flights?

You could potentially save up to 43% on your flight if you consider stops on a Denver to Panama City flight.

How have Denver to Panama City flight prices changed over time?

As of October 2025, prices for Denver to Panama City flights are approximately 39% more expensive when compared to flights at the same time last year.

When to book flights from Denver to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Denver to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Denver to Panama City (DEN to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to Panama City

Best Price Found

$174

Fastest flight time

5h 45m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Denver in the past 72 hours is $174. The best round-trip flight deal from Denver to Panama City found on momondo in the last 72 hours is $466.
The fastest flight from Denver to Panama City takes 5h 45m
Direct flights go from Denver to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is Denver Intl to Panama City Tocumen Intl by plane?

    Panama City Tocumen Intl is 2639.1 mi away from Denver Intl. Flights usually cover this in 5h 51m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Denver Intl Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Denver Intl Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Denver Intl Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Denver Intl Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Denver Intl Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Denver to Panama City?

  • What is the most popular airline from Denver to Panama City?

Best airlines flying from Denver to Panama City

Compare and see reviews for airlines that fly from Denver to Panama City with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $487Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
DeltaPriceFrom $518Free CancellationRating
7.9
7,979 reviews
Search Delta flights
American AirlinesPriceFrom $527Free CancellationRating
7.2
11,028 reviews
Search American Airlines flights
United AirlinesPriceFrom $527Free CancellationRating
7.4
8,988 reviews
Search United Airlines flights

  • Copa Airlines Flights From Denver to Panama City

    Copa Airlines is one of the most popular airlines flying from Denver to Panama City, operating 2 flights/week on average for this route. A good Copa Airlines flight deal for Denver to Panama City starts from $487 round-trip, up to an average price of $637. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Denver to Panama City

    Another popular option for Denver to Panama City flights is United Airlines (7.4/10, 8,988 ratings). United Airlines flies from Denver to Panama City around 2 times per week, with deals starting from $527 round-trip and rising to an average price of around $689.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Denver to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Denver to Panama City for you.

Can I find flights from Denver to Panama City with flexible booking policies on momondo?

All flight searches from Denver to Panama City on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Denver to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Denver. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Denver to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Denver and alert you when they change.

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