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Cheap flights from Denver to Panama City from $320

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Denver to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
9:55 pm - 5:33 amDEN  Denver Intl-PTY Panama City Tocumen Intl
5h 38mnonstop
Copa Airlines Logo
12:56 pm - 5:15 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
6h 19mnonstop
$629Copa Airlines
Fri, Feb 19 - Mon, Mar 1
Copa Airlines Logo
9:56 pm - 5:33 amDEN  Denver Intl-PTY Panama City Tocumen Intl
5h 37mnonstop
Copa Airlines Logo
12:45 pm - 5:04 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
6h 19mnonstop
$629Copa Airlines
Sun, Feb 28 - Wed, Mar 3
Copa Airlines Logo
9:55 pm - 5:33 amDEN  Denver Intl-PTY Panama City Tocumen Intl
5h 38mnonstop
Copa Airlines Logo
12:56 pm - 5:15 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
6h 19mnonstop
$629Copa Airlines
Fri, Feb 19 - Mon, Mar 1
American Airlines Logo
5:32 pm - 3:55 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
20h 23m2 stops Dallas/Fort Worth Miami
American Airlines Logo
4:55 pm - 8:13 amPTY  Panama City Tocumen Intl-DEN Denver Intl
17h 18m2 stops Miami Dallas/Fort Worth
$649American Airlines
Fri, Jan 15 - Thu, Jan 21
American Airlines Logo
11:59 pm - 1:25 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
11h 26m1 stop Miami
American Airlines Logo
2:25 pm - 10:03 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
9h 38m1 stop Miami
$654American Airlines
Wed, Feb 17 - Sun, Feb 28
American Airlines Logo
11:59 pm - 1:25 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
11h 26m1 stop Miami
American Airlines Logo
2:25 pm - 8:11 amPTY  Panama City Tocumen Intl-DEN Denver Intl
19h 46m2 stops Miami Dallas/Fort Worth
$659American Airlines
Wed, Feb 17 - Sun, Feb 28
Delta Logo
5:09 pm - 12:26 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
17h 17m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:29 pm - 11:17 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
9h 48m1 stop Atlanta Hartsfield-Jackson
$664Delta
Fri, Jan 15 - Sat, Jan 23
Delta Logo
5:09 pm - 12:21 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
17h 12m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:29 pm - 11:17 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
9h 48m1 stop Atlanta Hartsfield-Jackson
$664Delta
Fri, Jan 29 - Sun, Feb 7
United Airlines Logo
5:00 am - 2:14 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
8h 14m1 stop Houston George Bush Intcntl
United Airlines Logo
7:55 am - 4:24 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
9h 29m1 stop Houston George Bush Intcntl
$772United Airlines
Sat, Apr 17 - Fri, Apr 30
United Airlines Logo
5:00 am - 2:14 pmDEN  Denver Intl-PTY Panama City Tocumen Intl
8h 14m1 stop Houston George Bush Intcntl
United Airlines Logo
10:00 am - 7:45 pmPTY  Panama City Tocumen Intl-DEN Denver Intl
10h 45m1 stop Houston George Bush Intcntl
$772United Airlines
Fri, Apr 23 - Tue, Apr 27

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Copa Airlines flights from Denver to Panama City

Our best Copa Airlines deals on Denver to Panama City flight tickets
Copa Airlines
Feb 19
DEN9:55 pmDenver Intl
5h 38m
PTY5:33 amPanama City Tocumen Intl
Mar 1
PTY12:56 pmPanama City Tocumen Intl
6h 19m
DEN5:15 pmDenver Intl
$629
Copa Airlines
Feb 19
DEN9:55 pmDenver Intl
5h 38m
PTY5:33 amPanama City Tocumen Intl
Mar 1
PTY12:56 pmPanama City Tocumen Intl
6h 19m
DEN5:15 pmDenver Intl
$649
Copa Airlines
Jan 29
DEN9:50 pmDenver Intl
5h 43m
PTY5:33 amPanama City Tocumen Intl
Feb 7
PTY12:56 pmPanama City Tocumen Intl
6h 18m
DEN5:14 pmDenver Intl
$652

American Airlines flights from Denver to Panama City

Our best American Airlines deals on Denver to Panama City flight tickets
American Airlines
Feb 17
DEN11:59 pmDenver Intl
11h 26m
1 stop
PTY1:25 pmPanama City Tocumen Intl
Feb 28
PTY2:25 pmPanama City Tocumen Intl
9h 38m
1 stop
DEN10:03 pmDenver Intl
$654
American Airlines
Feb 17
DEN11:59 pmDenver Intl
11h 26m
1 stop
PTY1:25 pmPanama City Tocumen Intl
Feb 28
PTY2:25 pmPanama City Tocumen Intl
19h 46m
2 stops
DEN8:11 amDenver Intl
$659
American Airlines
Jan 15
DEN5:32 pmDenver Intl
20h 23m
2 stops
PTY3:55 pmPanama City Tocumen Intl
Jan 21
PTY4:55 pmPanama City Tocumen Intl
20h 37m
1 stop
DEN11:32 amDenver Intl
$665

momondo Fare Finder

 
Use the filters below to find and compare flights from Denver to Panama City that are best for you.

Fly from

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Route

Depart

Return

Price

Cheapest round-trip

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Fri 2/19

9:55 pm-5:33 am

Nonstop5h 38m

Panama City Tocumen Intl

Mon 3/1

12:56 pm-5:15 pm

Nonstop6h 19m

$629
Quickest round-trip

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Sun 2/28

9:56 pm-5:33 am

Nonstop5h 37m

Panama City Tocumen Intl

Wed 3/3

12:45 pm-5:04 pm

Nonstop6h 19m

$629

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Fri 2/19

9:55 pm-5:33 am

Nonstop5h 38m

Panama City Tocumen Intl

Mon 3/1

12:56 pm-5:15 pm

Nonstop6h 19m

$629

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Fri 1/15

5:32 pm-3:55 pm

2 stops20h 23m

Panama City Tocumen Intl

Thu 1/21

4:55 pm-8:13 am

2 stops17h 18m

$649

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Wed 2/17

11:59 pm-1:25 pm

1 stop11h 26m

Panama City Tocumen Intl

Sun 2/28

2:25 pm-10:03 pm

1 stop9h 38m

$654

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Wed 2/17

11:59 pm-1:25 pm

1 stop11h 26m

Panama City Tocumen Intl

Sun 2/28

2:25 pm-8:11 am

2 stops19h 46m

$659

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Fri 1/15

5:09 pm-12:26 pm

1 stop17h 17m

Panama City Tocumen Intl

Sat 1/23

3:29 pm-11:17 pm

1 stop9h 48m

$664

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Fri 1/29

5:09 pm-12:21 pm

1 stop17h 12m

Panama City Tocumen Intl

Sun 2/7

3:29 pm-11:17 pm

1 stop9h 48m

$664

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Sat 4/17

5:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Fri 4/30

7:55 am-4:24 pm

1 stop9h 29m

$772

DenverPanama City

DEN Denver Intl - PTY Panama City Tocumen Intl

DENPTY

Denver Intl

Fri 4/23

5:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Tue 4/27

10:00 am-7:45 pm

1 stop10h 45m

$772

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Denver to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Denver and Panama City?

Prices are currently low for flights on this route.

Typical prices usually range from $672 to $797.
The lowest price recently found on this route was $629.

What is the cheapest month to fly to Panama City?

In general, May is the cheapest month to fly from Denver to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $602. If you’re not able to fly to Panama City in May, then April is your next best option. Flight prices from Denver to Panama City during April average around $602.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $539. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $659. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest Denver Intl to Panama City Tocumen Intl flight route?

Fly from Denver Intl to Panama City Tocumen Intl for the best Denver Intl - Panama City Tocumen Intl flight prices

How far in advance should I book a flight from Denver to Panama City?

You are more likely to see cheaper flights to Panama City from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $688 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Denver for as low as $569 on momondo.

What cabin class options are available on Denver to Panama City flights?

There are 3 cabin classes available to choose from on Denver to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Denver to Panama City flights?

No. A direct flight is the cheapest option for a flight between Denver to Panama City.

How have Denver to Panama City flight prices changed over time?

As of November 2026, prices for Denver to Panama City flights are approximately 96% more expensive when compared to flights at the same time last year.

When to book flights from Denver to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Denver to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Denver to Panama City (DEN to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to Panama City

Best Price Found

$320

Fastest flight time

5h 35m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Denver in the past 72 hours is $320. The best round-trip flight deal from Denver to Panama City found on momondo in the last 72 hours is $629.
The fastest flight from Denver to Panama City takes 5h 35m
Direct flights go from Denver to Panama City every day.
There is 1 airport in Panama City. From Denver there are direct flights to Panama City Tocumen Intl (PTY).
Search flight deals

Frequently asked questions about flying from Denver to Panama City

  • How far is Denver Intl to Panama City Tocumen Intl by plane?

    Panama City Tocumen Intl is 2639.1 mi away from Denver Intl. Flights usually cover this in 5h 35m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Denver Intl Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Denver Intl Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Denver Intl Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Denver Intl Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Denver Intl Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Denver to Panama City?

  • What is the most popular airline from Denver to Panama City?

Best airlines flying from Denver to Panama City

Compare and see reviews for airlines that fly from Denver to Panama City with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $482Free CancellationRating
7.6
1,552 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $531Free CancellationRating
7.3
10,460 reviews
Search United Airlines flights
American AirlinesPriceFrom $634Free CancellationRating
7.0
12,224 reviews
Search American Airlines flights

  • Copa Airlines Flights From Denver to Panama City

    Copa Airlines is one of the most popular airlines flying from Denver to Panama City, operating 5 flights/week on average for this route. A good Copa Airlines flight deal for Denver to Panama City starts from $482 round-trip, up to an average price of $676. Our users have rated Copa Airlines at 7.6/10.

  • United Airlines Flights From Denver to Panama City

    Another popular option for Denver to Panama City flights is United Airlines (7.3/10, 10,460 ratings). United Airlines flies from Denver to Panama City around 5 times per week, with deals starting from $531 round-trip and rising to an average price of around $688.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Denver to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Denver to Panama City for you.

Can I find flights from Denver to Panama City with flexible booking policies on momondo?

All flight searches from Denver to Panama City on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Denver to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Denver. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Denver to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Denver and alert you when they change.

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