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Cheap flights from Denver to Panama City from $187

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Denver to Panama City departing on 9/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Denver to Panama City (DEN-PTY)

Cheap round-trip flights

Logo
6:55 pm - 8:11 amDEN-PTY
12h 16m1 stop
Logo
9:33 pm - 8:30 amPTY-DEN
11h 57m1 stop
$462
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Wed, Sep 17 - Sun, Sep 21
Logo
6:55 pm - 8:11 amDEN-PTY
12h 16m1 stop
Logo
9:33 pm - 8:30 amPTY-DEN
11h 57m1 stop
$471
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Sat, Sep 13 - Sat, Sep 27
Logo
12:34 am - 3:54 pmDEN-PTY
13h 20m1 stop
Logo
9:33 pm - 8:33 amPTY-DEN
13h 00m1 stop
$484
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Wed, Nov 5 - Thu, Nov 13
Logo
12:34 am - 4:06 pmDEN-PTY
14h 32m1 stop
Logo
9:33 pm - 8:33 amPTY-DEN
12h 00m1 stop
$489
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Sat, Oct 25 - Wed, Oct 29
Copa Airlines Logo
9:36 pm - 5:33 amDEN-PTY
5h 57mnonstop
Copa Airlines Logo
12:56 pm - 5:17 pmPTY-DEN
6h 21mnonstop
$535Copa Airlines
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Tue, Nov 25 - Tue, Dec 2
American Airlines Logo
11:59 pm - 1:38 pmDEN-PTY
11h 39m2 stops
American Airlines Logo
2:50 pm - 9:29 amPTY-DEN
20h 39m2 stops
$539American Airlines
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Mon, Dec 1 - Fri, Dec 5
Copa Airlines Logo
9:36 pm - 5:33 amDEN-PTY
5h 57mnonstop
Copa Airlines Logo
12:56 pm - 5:17 pmPTY-DEN
6h 21mnonstop
$548Copa Airlines
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Wed, Nov 19 - Fri, Nov 28
American Airlines Logo
12:18 am - 1:38 pmDEN-PTY
11h 20m1 stop
American Airlines Logo
2:43 pm - 11:18 pmPTY-DEN
10h 35m1 stop
$549American Airlines
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Mon, Nov 24 - Tue, Dec 2
Delta Logo
7:05 am - 8:04 pmDEN-PTY
10h 59m1 stop
Delta Logo
3:27 pm - 10:49 pmPTY-DEN
9h 22m1 stop
$559Delta
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Fri, Jan 9 - Sun, Jan 18
Delta Logo
6:20 pm - 1:55 pmDEN-PTY
17h 35m1 stop
Delta Logo
8:05 am - 10:49 pmPTY-DEN
16h 44m1 stop
$579Delta
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Sun, Jan 4 - Sat, Jan 17

Copa Airlines flights from Denver to Panama City

Our best Copa Airlines deals on Denver to Panama City flight tickets
Copa Airlines
Nov 25
DEN9:36 pmDenver Intl
5h 57m
PTY5:33 amPanama City Tocumen Intl
Dec 2
PTY12:56 pmPanama City Tocumen Intl
6h 21m
DEN5:17 pmDenver Intl
$535
Find similar
Copa Airlines
Nov 19
DEN9:36 pmDenver Intl
5h 57m
PTY5:33 amPanama City Tocumen Intl
Nov 28
PTY12:56 pmPanama City Tocumen Intl
6h 21m
DEN5:17 pmDenver Intl
$548
Find similar
Copa Airlines
Sep 11
DEN10:47 pmDenver Intl
5h 46m
PTY5:33 amPanama City Tocumen Intl
Sep 18
PTY12:56 pmPanama City Tocumen Intl
6h 11m
DEN6:07 pmDenver Intl
$688
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American Airlines flights from Denver to Panama City

Our best American Airlines deals on Denver to Panama City flight tickets
American Airlines
Dec 1
DEN11:59 pmDenver Intl
11h 39m
2 stops
PTY1:38 pmPanama City Tocumen Intl
Dec 5
PTY2:50 pmPanama City Tocumen Intl
20h 39m
2 stops
DEN9:29 amDenver Intl
$539
Find similar
American Airlines
Nov 24
DEN12:18 amDenver Intl
11h 20m
1 stop
PTY1:38 pmPanama City Tocumen Intl
Dec 2
PTY2:43 pmPanama City Tocumen Intl
10h 35m
1 stop
DEN11:18 pmDenver Intl
$549
Find similar
American Airlines
Feb 18
DEN4:54 pmDenver Intl
20h 06m
2 stops
PTY3:00 pmPanama City Tocumen Intl
Feb 28
PTY2:30 pmPanama City Tocumen Intl
20h 56m
2 stops
DEN9:26 amDenver Intl
$554
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momondo Fare Finder

 
Customize your flight search to find flights from Denver to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 28, 2025.
Use the filters below to find and compare flights from Denver to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Wed 9/17

6:55 pm-8:11 am

1 stop12h 16m

Panama City Tocumen Intl

Sun 9/21

9:33 pm-8:30 am

1 stop11h 57m

$462

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Sat 9/13

6:55 pm-8:11 am

1 stop12h 16m

Panama City Tocumen Intl

Sat 9/27

9:33 pm-8:30 am

1 stop11h 57m

$471

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Wed 11/5

12:34 am-3:54 pm

1 stop13h 20m

Panama City Tocumen Intl

Thu 11/13

9:33 pm-8:33 am

1 stop13h 00m

$484

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Sat 10/25

12:34 am-4:06 pm

1 stop14h 32m

Panama City Tocumen Intl

Wed 10/29

9:33 pm-8:33 am

1 stop12h 00m

$489

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Tue 11/25

9:36 pm-5:33 am

Nonstop5h 57m

Panama City Tocumen Intl

Tue 12/2

12:56 pm-5:17 pm

Nonstop6h 21m

$535

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Mon 12/1

11:59 pm-1:38 pm

2 stops11h 39m

Panama City Tocumen Intl

Fri 12/5

2:50 pm-9:29 am

2 stops20h 39m

$539

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Wed 11/19

9:36 pm-5:33 am

Nonstop5h 57m

Panama City Tocumen Intl

Fri 11/28

12:56 pm-5:17 pm

Nonstop6h 21m

$548

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Mon 11/24

12:18 am-1:38 pm

1 stop11h 20m

Panama City Tocumen Intl

Tue 12/2

2:43 pm-11:18 pm

1 stop10h 35m

$549

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Fri 1/9

7:05 am-8:04 pm

1 stop10h 59m

Panama City Tocumen Intl

Sun 1/18

3:27 pm-10:49 pm

1 stop9h 22m

$559

DenverPanama City

DEN - PTY

DENPTY

Denver Intl

Sun 1/4

6:20 pm-1:55 pm

1 stop17h 35m

Panama City Tocumen Intl

Sat 1/17

8:05 am-10:49 pm

1 stop16h 44m

$579

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Denver to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

In general, October is the cheapest month to fly from Denver to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $512. If you’re not able to fly to Panama City in October, then September is your next best option. Flight prices from Denver to Panama City during September average around $527.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $481. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $629. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Denver to Panama City during this time can be as low as $587. Try not to purchase tickets in the afternoon because they tend to be around $733. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Denver Intl to Panama City Tocumen Intl flight route?

Fly from Denver Intl to Panama City Tocumen Intl for the best Denver Intl - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $631 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Denver for as low as $560 on momondo.

What cabin class options are available on Denver Intl to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Denver Intl to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Denver to Panama City flights?

No. A direct flight is the cheapest option for a flight between Denver to Panama City.

How have Denver to Panama City flight prices changed over time?

As of August 2025, prices for Denver to Panama City flights are approximately 58% more expensive when compared to flights at the same time last year.

When to book flights from Denver to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Denver to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Denver to Panama City (DEN to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to Panama City

Best Price Found

$197

Fastest flight time

5h 46m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Denver in the past 72 hours is $197. The best round-trip flight deal from Denver to Panama City found on momondo in the last 72 hours is $436.
The fastest flight from Denver to Panama City takes 5h 46m
Direct flights go from Denver to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is Denver Intl to Panama City Tocumen Intl by plane?

    Panama City Tocumen Intl is 2639.1 mi away from Denver Intl. Flights usually cover this in 5h 57m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Denver Intl Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Denver Intl Airport to Panama City Tocumen Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Denver Intl Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Denver Intl Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Denver Intl Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Denver to Panama City?

  • What is the most popular airline from Denver to Panama City?

Best airlines flying from Denver to Panama City

Compare and see reviews for airlines that fly from Denver to Panama City with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $473Free CancellationRating
7.5
1,517 reviews
Search Copa Airlines flights
American AirlinesPriceFrom $491Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $518Free CancellationRating
7.9
7,977 reviews
Search Delta flights
United AirlinesPriceFrom $527Free CancellationRating
7.4
8,944 reviews
Search United Airlines flights

  • Copa Airlines Flights From Denver to Panama City

    Copa Airlines is one of the most popular airlines flying from Denver to Panama City, operating 5 flights/week on average for this route. A good Copa Airlines flight deal for Denver to Panama City starts from $473 round-trip, up to an average price of $629. Our users have rated Copa Airlines at 7.5/10.

  • United Airlines Flights From Denver to Panama City

    Another popular option for Denver to Panama City flights is United Airlines (7.4/10, 8,944 ratings). United Airlines flies from Denver to Panama City around 5 times per week, with deals starting from $527 round-trip and rising to an average price of around $699.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Denver to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Denver to Panama City for you.

Can I find flights from Denver to Panama City with flexible booking policies on momondo?

All flight searches from Denver to Panama City on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Denver to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Denver. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Denver to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Denver and alert you when they change.

An easier way to manage your Panama City trip

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