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Cheap flights from Cusco to Santiago from $110

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Cusco to Santiago departing on 5/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Multiple Airlines Logo
10:32 pm - 10:49 amCUZ-SCL
10h 17m1 stop
Multiple Airlines Logo
11:05 pm - 9:05 pmSCL-CUZ
24h 00m1 stop
$231Multiple Airlines
Find Deal
Mon, Dec 15 - Wed, Dec 31
Sky Airline Logo
11:10 am - 1:45 pmCUZ-SCL
25h 35m1 stop
Sky Airline Logo
9:15 pm - 7:20 amSCL-CUZ
11h 05m1 stop
$262Sky Airline
Find Deal
Sun, Apr 5 - Wed, Apr 8
Multiple Airlines Logo
8:30 pm - 12:15 pmCUZ-SCL
13h 45m2 stops
Multiple Airlines Logo
9:29 pm - 6:26 amSCL-CUZ
10h 57m1 stop
$271Multiple Airlines
Find Deal
Mon, Dec 15 - Wed, Dec 31
Multiple Airlines Logo
9:20 pm - 9:10 pmCUZ-SCL
22h 50m1 stop
Multiple Airlines Logo
4:51 am - 11:04 amSCL-CUZ
7h 13m1 stop
$274Multiple Airlines
Find Deal
Thu, Apr 9 - Sun, Apr 12
Sky Airline Logo
7:05 am - 12:15 pmCUZ-SCL
28h 10m2 stops
Sky Airline Logo
9:15 pm - 6:25 amSCL-CUZ
10h 10m1 stop
$276Sky Airline
Find Deal
Sun, Apr 5 - Wed, Apr 8
Sky Airline Logo
9:20 pm - 1:45 pmCUZ-SCL
15h 25m1 stop
Sky Airline Logo
1:55 am - 5:50 pmSCL-CUZ
16h 55m2 stops
$279Sky Airline
Find Deal
Thu, Apr 9 - Sat, Apr 11
JetSMART Logo
11:12 am - 4:01 amCUZ-SCL
15h 49m1 stop
JetSMART Logo
4:51 am - 4:44 pmSCL-CUZ
12h 53m1 stop
$304JetSMART
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Wed, Apr 8 - Sun, Apr 12
LATAM Airlines Logo
9:30 am - 1:50 pmCUZ-SCL
3h 20mnonstop
LATAM Airlines Logo
7:45 pm - 10:15 pmSCL-CUZ
3h 30mnonstop
$337LATAM Airlines
Find Deal
Thu, Apr 9 - Sun, Apr 12
LATAM Airlines Logo
9:30 am - 2:45 pmCUZ-SCL
3h 15mnonstop
LATAM Airlines Logo
4:35 am - 9:25 amSCL-CUZ
6h 50m1 stop
$348LATAM Airlines
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Thu, Dec 25 - Wed, Dec 31
JetSMART Logo
9:02 pm - 12:35 amCUZ-SCL
49h 33m2 stops
JetSMART Logo
9:15 am - 9:26 pmSCL-CUZ
38h 11m2 stops
$482JetSMART
Find Deal
Wed, Mar 11 - Mon, Mar 16

JetSMART flights from Cusco to Santiago

Our best JetSMART deals on Cusco to Santiago flight tickets
JetSMART
Apr 8
CUZ11:12 amCusco Velazco Astete
15h 49m
1 stop
SCL4:01 amSantiago Arturo Merino Benitez
Apr 12
SCL4:51 amSantiago Arturo Merino Benitez
12h 53m
1 stop
CUZ4:44 pmCusco Velazco Astete
$304
Find similar
JetSMART
Nov 14
CUZ11:22 amCusco Velazco Astete
15h 52m
1 stop
SCL5:14 amSantiago Arturo Merino Benitez
Nov 21
SCL5:59 amSantiago Arturo Merino Benitez
17h 57m
1 stop
CUZ9:56 pmCusco Velazco Astete
$466
Find similar
JetSMART
Mar 11
CUZ9:02 pmCusco Velazco Astete
49h 33m
2 stops
SCL12:35 amSantiago Arturo Merino Benitez
Mar 16
SCL9:15 amSantiago Arturo Merino Benitez
38h 11m
2 stops
CUZ9:26 pmCusco Velazco Astete
$482
Find similar

LATAM Airlines flights from Cusco to Santiago

Our best LATAM Airlines deals on Cusco to Santiago flight tickets
LATAM Airlines
Apr 9
CUZ9:30 amCusco Velazco Astete
3h 20m
SCL1:50 pmSantiago Arturo Merino Benitez
Apr 12
SCL7:45 pmSantiago Arturo Merino Benitez
3h 30m
CUZ10:15 pmCusco Velazco Astete
$337
Find similar
LATAM Airlines
Dec 25
CUZ9:30 amCusco Velazco Astete
3h 15m
SCL2:45 pmSantiago Arturo Merino Benitez
Dec 31
SCL4:35 amSantiago Arturo Merino Benitez
6h 50m
1 stop
CUZ9:25 amCusco Velazco Astete
$348
Find similar
LATAM Airlines
Dec 15
CUZ9:30 amCusco Velazco Astete
3h 15m
SCL2:45 pmSantiago Arturo Merino Benitez
Dec 31
SCL3:45 pmSantiago Arturo Merino Benitez
3h 30m
CUZ5:15 pmCusco Velazco Astete
$425
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Cusco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 10, 2025.
Use the filters below to find and compare flights from Cusco to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Mon 12/15

10:32 pm-10:49 am

1 stop10h 17m

Santiago Arturo Merino Benitez

Wed 12/31

11:05 pm-9:05 pm

1 stop24h 00m

$231

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Sun 4/5

11:10 am-1:45 pm

1 stop25h 35m

Santiago Arturo Merino Benitez

Wed 4/8

9:15 pm-7:20 am

1 stop11h 05m

$262

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Mon 12/15

8:30 pm-12:15 pm

2 stops13h 45m

Santiago Arturo Merino Benitez

Wed 12/31

9:29 pm-6:26 am

1 stop10h 57m

$271

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Thu 4/9

9:20 pm-9:10 pm

1 stop22h 50m

Santiago Arturo Merino Benitez

Sun 4/12

4:51 am-11:04 am

1 stop7h 13m

$274

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Sun 4/5

7:05 am-12:15 pm

2 stops28h 10m

Santiago Arturo Merino Benitez

Wed 4/8

9:15 pm-6:25 am

1 stop10h 10m

$276

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Thu 4/9

9:20 pm-1:45 pm

1 stop15h 25m

Santiago Arturo Merino Benitez

Sat 4/11

1:55 am-5:50 pm

2 stops16h 55m

$279

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Wed 4/8

11:12 am-4:01 am

1 stop15h 49m

Santiago Arturo Merino Benitez

Sun 4/12

4:51 am-4:44 pm

1 stop12h 53m

$304

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Thu 4/9

9:30 am-1:50 pm

Nonstop3h 20m

Santiago Arturo Merino Benitez

Sun 4/12

7:45 pm-10:15 pm

Nonstop3h 30m

$337

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Thu 12/25

9:30 am-2:45 pm

Nonstop3h 15m

Santiago Arturo Merino Benitez

Wed 12/31

4:35 am-9:25 am

1 stop6h 50m

$348

CuscoSantiago

CUZ - SCL

CUZSCL

Cusco Velazco Astete

Wed 3/11

9:02 pm-12:35 am

2 stops49h 33m

Santiago Arturo Merino Benitez

Mon 3/16

9:15 am-9:26 pm

2 stops38h 11m

$482

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santiago from

How to get the cheapest flight ticket from Cusco to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santiago?

In general, October is the cheapest month to fly from Cusco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $248. If you don’t want to visit Santiago in October, then you should wait until April to fly from Cusco, when ticket prices are also cheap, with an average price of $282.

What is the cheapest time of day to depart on your flight to Santiago?

In the morning is the cheapest time of day to fly from Cusco to Santiago when you can find flight prices for as low as $414. Flying to Santiago in the morning is an ideal time because this is during off-peak travel hours. In the evening is when there is more demand to fly to Santiago, so prices are often more expensive at around $469 per ticket.

What is the cheapest Cusco Velazco Astete to Santiago Arturo Merino Benitez flight route?

Fly from Cusco Velazco Astete to Santiago Arturo Merino Benitez for the best Cusco Velazco Astete - Santiago Arturo Merino Benitez flight prices

How far in advance should I book a flight to Santiago?

You are more likely to see cheaper flights to Santiago from Cusco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $315 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Cusco for as low as $161 on momondo.

What cabin class options are available on Cusco Velazco Astete to Santiago Arturo Merino Benitez flights?

There are 3 cabin classes available to choose from on Cusco Velazco Astete to Santiago Arturo Merino Benitez flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Cusco to Santiago flights?

You could potentially save up to 25% on your flight if you consider stops on a Cusco to Santiago flight.

How have Cusco to Santiago flight prices changed over time?

As of November 2025, prices for Cusco to Santiago flights are approximately 8% more expensive when compared to flights at the same time last year.

When to book flights from Cusco to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Cusco to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Cusco to Santiago (CUZ to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Cusco to Santiago

Fastest flight time

3h 15m

Direct flights

Every day

Airports in Santiago

1 airport
The fastest flight from Cusco to Santiago takes 3h 15m
Direct flights go from Cusco to Santiago every day.
There is 1 airport near Santiago: Santiago Arturo Merino Benitez (SCL)
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  • How far is Cusco Velazco Astete to Santiago Arturo Merino Benitez by plane?

    Santiago Arturo Merino Benitez is 1377.5 mi away from Cusco Velazco Astete. By plane, this route typically takes 3h 15m.

  • When did momondo last update prices for flights from Cusco Velazco Astete Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Cusco Velazco Astete Airport to Santiago Arturo Merino Benitez Airport refresh daily.

  • How many operators does momondo search for flights from Cusco Velazco Astete Airport to Santiago Arturo Merino Benitez Airport?

  • How old do you have to be to fly from Cusco Velazco Astete Airport to Santiago Arturo Merino Benitez Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Cusco Velazco Astete Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The necessary travel and health documents for your Santiago Arturo Merino Benitez Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Cusco to Santiago?

  • What is the most popular airline from Cusco to Santiago?

Best airlines flying from Cusco to Santiago

Compare and see reviews for airlines that fly from Cusco to Santiago with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $292Free CancellationRating
7.5
1,872 reviews
Search LATAM Airlines flights

  • LATAM Airlines Flights From Cusco to Santiago

    The lowest priced LATAM Airlines flight from Cusco to Santiago from the last 72 hours was $292. Generally, LATAM Airlines has 10 flights on this route every week with an average price of $469. LATAM Airlines is rated 7.5/10 by our users.

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Viña del Mar
Santa Cruz
Valparaíso
Valle Nevado
San Fernando
Pichilemu

Why use momondo?

Why should I use momondo to find a flight deal from Cusco to Santiago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santiago from Cusco.

Can I find flights from Cusco to Santiago with flexible booking policies on momondo?

Yes. All flights to Santiago from Cusco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Cusco to Santiago?

Once you have performed a search for Cusco to Santiago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Cusco to Santiago right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Cusco to Santiago now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santiago and let you know when they change.

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