Cheap flights from Cusco to Santiago from $136

In general, October is the cheapest month to fly from Cusco to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $245. If you don’t want to visit Santiago in October, then you should wait until December to fly from Cusco, when ticket prices are also cheap, with an average price of $259.

Fly from Cusco Velazco Astete to Santiago Arturo Merino Benitez for the best Cusco Velazco Astete - Santiago Arturo Merino Benitez flight prices

You are more likely to see cheaper flights to Santiago from Cusco when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around $328 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Cusco for as low as $178 on momondo.

There is only 1 cabin class available to choose from on Cusco to Santiago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 31% on your flight if you consider stops on a Cusco to Santiago flight.

As of September 2026, prices for Cusco to Santiago flights are approximately 12% cheaper when compared to flights at the same time last year.

Historically, on average around 8% of flights between Cusco and Santiago have experienced a delay on any given week. The average delay length over the past 12 months has been 202 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights in the early afternoon have, in the past, seen delays more frequently in comparison.

Friday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the least number of delays on this route over the last 12 months; with about 8% of their flights experiencing any sort of delay.