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Cheap flights from Charleston to Panama City from $144

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charleston to Panama City departing on 9/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Charleston to Panama City

Cheap round-trip flights

American Airlines Logo
6:00 am - 2:03 pmCHS-PTY
9h 03m1 stop
American Airlines Logo
3:15 pm - 11:59 pmPTY-CHS
7h 44m1 stop
$369American Airlines
Find Deal
Fri, Oct 24 - Fri, Oct 31
American Airlines Logo
6:00 am - 2:03 pmCHS-PTY
9h 03m1 stop
American Airlines Logo
3:15 pm - 1:23 pmPTY-CHS
21h 08m2 stops
$374American Airlines
Find Deal
Fri, Oct 24 - Fri, Oct 31
American Airlines Logo
4:30 pm - 2:03 pmCHS-PTY
22h 33m2 stops
American Airlines Logo
3:15 pm - 8:16 amPTY-CHS
16h 01m2 stops
$388American Airlines
Find Deal
Thu, Oct 9 - Thu, Oct 16
American Airlines Logo
7:54 pm - 2:03 pmCHS-PTY
19h 09m2 stops
American Airlines Logo
3:15 pm - 11:59 pmPTY-CHS
7h 44m1 stop
$394American Airlines
Find Deal
Fri, Oct 17 - Fri, Oct 24
American Airlines Logo
7:44 pm - 2:03 pmCHS-PTY
19h 19m1 stop
American Airlines Logo
3:15 pm - 11:59 pmPTY-CHS
7h 44m1 stop
$398American Airlines
Find Deal
Fri, Oct 17 - Fri, Oct 24
United Airlines Logo
11:00 am - 8:02 pmCHS-PTY
9h 02m1 stop
United Airlines Logo
11:55 pm - 9:50 amPTY-CHS
9h 55m1 stop
$409United Airlines
Find Deal
Fri, Jan 16 - Sun, Feb 1
Logo
10:11 am - 4:30 pmCHS-PTY
31h 19m3 stops
Logo
9:55 am - 9:06 amPTY-CHS
22h 11m3 stops
$709
Find Deal
Thu, Oct 9 - Thu, Oct 16
Logo
10:11 am - 9:10 pmCHS-PTY
11h 59m2 stops
Logo
9:55 am - 9:06 amPTY-CHS
22h 11m3 stops
$733
Find Deal
Thu, Oct 9 - Thu, Oct 16
Delta Logo
8:02 pm - 8:00 pmCHS-PTY
23h 58m1 stop
Delta Logo
8:00 am - 3:09 pmPTY-CHS
7h 09m1 stop
$751Delta
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Tue, Dec 23 - Mon, Dec 29
Delta Logo
8:02 pm - 8:00 pmCHS-PTY
23h 58m1 stop
Delta Logo
8:00 am - 3:09 pmPTY-CHS
7h 09m1 stop
$809Delta
Find Deal
Tue, Dec 23 - Sun, Dec 28

American Airlines flights from Charleston to Panama City

Our best American Airlines deals on Charleston to Panama City flight tickets
American Airlines
Oct 24
CHS6:00 amCharleston
9h 03m
1 stop
PTY2:03 pmPanama City Tocumen Intl
Oct 31
PTY3:15 pmPanama City Tocumen Intl
7h 44m
1 stop
CHS11:59 pmCharleston
$369
Find similar
American Airlines
Oct 24
CHS6:00 amCharleston
9h 03m
1 stop
PTY2:03 pmPanama City Tocumen Intl
Oct 31
PTY3:15 pmPanama City Tocumen Intl
21h 08m
2 stops
CHS1:23 pmCharleston
$374
Find similar
American Airlines
Oct 9
CHS4:30 pmCharleston
22h 33m
2 stops
PTY2:03 pmPanama City Tocumen Intl
Oct 16
PTY3:15 pmPanama City Tocumen Intl
16h 01m
2 stops
CHS8:16 amCharleston
$388
Find similar

Delta flights from Charleston to Panama City

Our best Delta deals on Charleston to Panama City flight tickets
Delta
Dec 23
CHS8:02 pmCharleston
23h 58m
1 stop
PTY8:00 pmPanama City Tocumen Intl
Dec 29
PTY8:00 amPanama City Tocumen Intl
7h 09m
1 stop
CHS3:09 pmCharleston
$751
Find similar
Delta
Dec 23
CHS8:02 pmCharleston
23h 58m
1 stop
PTY8:00 pmPanama City Tocumen Intl
Dec 28
PTY8:00 amPanama City Tocumen Intl
7h 09m
1 stop
CHS3:09 pmCharleston
$809
Find similar
Delta
Dec 24
CHS8:30 amCharleston
11h 30m
1 stop
PTY8:00 pmPanama City Tocumen Intl
Dec 28
PTY8:00 amPanama City Tocumen Intl
7h 09m
1 stop
CHS3:09 pmCharleston
$914
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Charleston to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Charleston to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 10/24

6:00 am-2:03 pm

1 stop9h 03m

Panama City Tocumen Intl

Fri 10/31

3:15 pm-11:59 pm

1 stop7h 44m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 10/24

6:00 am-2:03 pm

1 stop9h 03m

Panama City Tocumen Intl

Fri 10/31

3:15 pm-1:23 pm

2 stops21h 08m

$374

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 10/9

4:30 pm-2:03 pm

2 stops22h 33m

Panama City Tocumen Intl

Thu 10/16

3:15 pm-8:16 am

2 stops16h 01m

$388

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 10/17

7:54 pm-2:03 pm

2 stops19h 09m

Panama City Tocumen Intl

Fri 10/24

3:15 pm-11:59 pm

1 stop7h 44m

$394

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 10/17

7:44 pm-2:03 pm

1 stop19h 19m

Panama City Tocumen Intl

Fri 10/24

3:15 pm-11:59 pm

1 stop7h 44m

$398

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 1/16

11:00 am-8:02 pm

1 stop9h 02m

Panama City Tocumen Intl

Sun 2/1

11:55 pm-9:50 am

1 stop9h 55m

$409

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 10/9

10:11 am-4:30 pm

3 stops31h 19m

Panama City Tocumen Intl

Thu 10/16

9:55 am-9:06 am

3 stops22h 11m

$709

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 10/9

10:11 am-9:10 pm

2 stops11h 59m

Panama City Tocumen Intl

Thu 10/16

9:55 am-9:06 am

3 stops22h 11m

$733

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 12/23

8:02 pm-8:00 pm

1 stop23h 58m

Panama City Tocumen Intl

Mon 12/29

8:00 am-3:09 pm

1 stop7h 09m

$751

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 12/23

8:02 pm-8:00 pm

1 stop23h 58m

Panama City Tocumen Intl

Sun 12/28

8:00 am-3:09 pm

1 stop7h 09m

$809

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Charleston to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Charleston and Panama City?

What is the cheapest month to fly to Panama City?

In general, November is the cheapest month to fly from Charleston to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $402. If you’re not able to fly to Panama City in November, then September is your next best option. Flight prices from Charleston to Panama City during September average around $444.

What is the cheapest day to depart on your flight to Panama City?

Our data shows that Wednesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $341. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $712. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

What is the cheapest time of day to depart on your flight to Panama City?

Our most recent data shows that the best time of day to fly to Panama City is in the evening. Flights from Charleston to Panama City during this time can be as low as $466. Try not to purchase tickets in the afternoon because they tend to be around $495. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Charleston to Panama City flights?

You could potentially save up to 3% on your flight if you consider stops on a Charleston to Panama City flight.

When to book flights from Charleston to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Charleston to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charleston to Panama City (CHS to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charleston to Panama City

Direct flights

None
There are no direct flights from Charleston to Panama City. There are no popular flight routes from Charleston to Panama City.
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  • How far is Charleston to Panama City Tocumen Intl by plane?

    The straight-line distance from Charleston to Panama City Tocumen Intl is 1643.0 mi. 6h 27m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Charleston Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Charleston Airport to Panama City Tocumen Intl Airport refresh daily.

  • How many operators does momondo search for flights from Charleston Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Charleston Airport to Panama City Tocumen Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Charleston Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The required travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City Tocumen Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Charleston to Panama City?

Best airlines flying from Charleston to Panama City

Compare and see reviews for airlines that fly from Charleston to Panama City with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $361Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $369Free CancellationRating
7.9
7,960 reviews
Search Delta flights
United AirlinesPriceFrom $391Free CancellationRating
7.4
8,937 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Charleston to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Charleston to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Charleston to Panama City with flexible booking policies on momondo?

Flights from Charleston to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Charleston to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Charleston. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Charleston to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charleston to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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