Cheap flights from California to Panama City from $272

In general, April is the cheapest month to fly from California to Panama City. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $685. If you’re not able to fly to Panama City in April, then February is your next best option. Flight prices from California to Panama City during February average around $685.

Our data shows that Tuesday is the least expensive day to fly to Panama City. Tickets to fly out on this day can be as low as $686. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $726. These prices are subject to change though, so be sure to set up a Price Alert for flights to Panama City.

Our most recent data shows that the best time of day to fly to Panama City is in the morning. Flights from California to Panama City during this time can be as low as $694. Try not to purchase tickets in the evening because they tend to be around $706. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from San Diego to Panama City Tocumen Intl for the best California - Panama City Tocumen Intl flight prices

You are more likely to see cheaper flights to Panama City from California when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around $749 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from California for as low as $680 on momondo.

There are 3 cabin classes available to choose from on California to Panama City flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines, Delta, and American Airlines are the most popular carriers operating from California to Panama City Tocumen Intl

Copa Airlines, United Airlines and Avianca are the top three most popular airlines that fly to Panama City from California according to our data. Copa Airlines is the first choice among our users, with 74% of people opting to fly with this airline when traveling to Panama City. Keep in mind that there are 4 different airlines that fly to Panama City on a routine basis, so you have a few additional options to choose from.

9 flights are operational daily from California to Panama City as of November 2026. The most popular departure time for this route is 1:00AM, with 60% of flights per day taking off in the morning.

As of November 2026, there are 69 flights per week flying from California to Panama City. The most common day of the week flights depart is Mon, with 17% of flights taking off on this day.