Welcome to the Holiday Inn Express near Houston NASA Space Center. Modern design & comfort unite at the Holiday Inn Express® Hotel & Suites Houston Space Center Clear Lake. Conveniently centered between Houston & Galveston, our hotel is the perfect choice whether you’re visiting Houston attractions, spending the day at the Kemah Boardwalk near Galveston Seawall Pleasure Pier or shopping at Baybrook Mall. The NASA Johnson Space Center is just 3 miles away along with an array of dining options! If you're in need of a hotel near Webster, TX for business, our more than 1,200 sq ft of meeting space is available if you need to host an event. Also, Clear Lake Regional Hospital, UTMB, Big League Dreams Baseball Park, Ellington Field Airport (EFD) & companies like Exxon & Marathon are nearby in neighboring Texas City. You will find our location convenient to the Galveston Cruise Terminals if you are taking a cruise. You can even park at our hotel until you return from your cruise. At the end of each day, return to our facility & let your stress melt away in the whirlpool, maintain your workout routine in the fitness center or stretch out in the poolside cabanas. Start your day the right way with a complimentary, hearty breakfast before flying out of the nearby Hobby Airport. Your satisfaction is our priority! We look forward to exceeding your expectations!