Top Hotels
Neighborhoods
Insights
FAQs
Hotels in St. Charles

Vacation rentals in St. Charles, MO

Find deals on vacation rentals in St. Charles, MO

momondo compares 3M+ hotel and accommodation options.

Top rentals in St. Charles

Find the perfect vacation rental for your stay in St. Charles
Price
$123
$859
Review Score
0+
6+
7+
8+
9+

Vacation rentals in popular neighborhoods in St. Charles

Below is the most popular neighborhood in St. Charles to stay in, as well as some of the best vacation rentals in each area
Downtown
Search rentals in Downtown
30-Night Minimum South Main Apartment Photo
Best value

30-Night Minimum South Main Apartment

St. Charles, MO, United States

10.0
#1 Most popular

Victorian Gem Steps from Main St - Sleeps 9 & Pets

St. Charles, MO, United States

9.4
The Lewis & Clark Hangout Photo
#2 Most popular

The Lewis & Clark Hangout

St. Charles, MO, United States

8.6
Home Near Main Street-Covered Patio-Hot Tub! Photo
#3 Most popular

Home Near Main Street-Covered Patio-Hot Tub!

St. Charles, MO, United States

9.4

Hostels and cheap hotels in St. Charles

These hotels and hostels usually make for a cheap way to stay in St. Charles
Cozy Loft from 1860 in Frenchtown facing Katy trail St Charles MO Photo

Cozy Loft from 1860 in Frenchtown facing Katy trail St Charles MO

St. Charles, MO, United States

10852525
Stunning Loft from 1860 in Frechtown St Charles Mo Photo

Stunning Loft from 1860 in Frechtown St Charles Mo

St. Charles, MO, United States

10876310
30-Night Minimum South Main Apartment Photo

30-Night Minimum South Main Apartment

St. Charles, MO, United States

10.0
10164778
Private Basement - Two King Beds and Hot Tub Photo

Private Basement - Two King Beds and Hot Tub

St. Charles, MO, United States

8.4
10095850
Cozy Clark Suite in Frenchtown Photo

Cozy Clark Suite in Frenchtown

St. Charles, MO, United States

9.4
11023616
Historic 5th Street House - Fully Rehabbed # 2 Photo

Historic 5th Street House - Fully Rehabbed # 2

St. Charles, MO, United States

8.2
10706969

Get the best value vacation rental in St. Charles

These St. Charles vacation rentals have the best prices for their ratings
30-Night Minimum South Main Apartment Photo

30-Night Minimum South Main Apartment

St. Charles, MO, United States

10.0
10164778
Private Basement - Two King Beds and Hot Tub Photo

Private Basement - Two King Beds and Hot Tub

St. Charles, MO, United States

8.4
10095850
Cozy Clark Suite in Frenchtown Photo

Cozy Clark Suite in Frenchtown

St. Charles, MO, United States

9.4
11023616
Historic 2-Bed Gem in St. Charles French Town Photo

Historic 2-Bed Gem in St. Charles French Town

St. Charles, MO, United States

9.7
10401826
6th street 101 - Walk to Main St Photo

6th street 101 - Walk to Main St

St. Charles, MO, United States

10.0
11479453
The Rustic Revival - Charming 2br Retreat Photo

The Rustic Revival - Charming 2br Retreat

St. Charles, MO, United States

10.0
11556352

momondo's favorite vacation rentals in St. Charles

Learn more about these user-preferred vacation rentals in St. Charles
Stunning Loft from 1860 in Frechtown St Charles Mo Photo

Stunning Loft from 1860 in Frechtown St Charles Mo

St. Charles, MO, United States

$136
Spacious Historic Townhouse - Character for All Photo

Spacious Historic Townhouse - Character for All

St. Charles, MO, United States

9.4
$214
The Rustic Revival - Charming 2br Retreat Photo

The Rustic Revival - Charming 2br Retreat

St. Charles, MO, United States

10.0
$212
The St. Charles Guest House, lovely historic home, fun for families and groups Photo

The St. Charles Guest House, lovely historic home, fun for families and groups

St. Charles, MO, United States

9.9
$297

604 1 Two Bedroom One Bath With King Nea

St. Charles, MO, United States

7.3
$213
Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!! Photo

Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!!

St. Charles, MO, United States

9.9
$297
St. Charles 1860's Gem - Sleeps 6! Photo

St. Charles 1860's Gem - Sleeps 6!

St. Charles, MO, United States

9.6
$193
Amazing Renovated Historic Loft On Main Street Photo

Amazing Renovated Historic Loft On Main Street

St. Charles, MO, United States

9.9
$205
The Lofts Of North Main Street Photo

The Lofts Of North Main Street

St. Charles, MO, United States

9.5
$195
Prime Loft of Main Street Photo

Prime Loft of Main Street

St. Charles, MO, United States

9.5
$196
Minutes from Main Street - Updated House w/ 4 Patios, Private Parking & Trolley Photo

Minutes from Main Street - Updated House w/ 4 Patios, Private Parking & Trolley

St. Charles, MO, United States

9.3
$278
Adorable Historic in the ️ of St. Charles Photo

Adorable Historic in the ️ of St. Charles

St. Charles, MO, United States

9.6
$195

Dreamy St Charles Retreat With Furnished

St. Charles, MO, United States

9.9
$363
The Loft on Main | Steps to Dining & Nightlife Photo

The Loft on Main | Steps to Dining & Nightlife

142 North Main St, St. Charles, MO, United States

8.8
$249
Rhythm Loft Above the Honky Tonk Photo

Rhythm Loft Above the Honky Tonk

St. Charles, MO, United States

9.1
$190
Backstage Loft Above Honky Tonk Photo

Backstage Loft Above Honky Tonk

St. Charles, MO, United States

8.5
$196
Main Street Living! 2 Bedroom Unit Right Photo

Main Street Living! 2 Bedroom Unit Right

St. Charles, MO, United States

9.1
$244
Historic headquarters of city founder! Gated parking! Photo

Historic headquarters of city founder! Gated parking!

St. Charles, MO, United States

10.0
$247
Historic 2-Bed Gem in St. Charles French Town Photo

Historic 2-Bed Gem in St. Charles French Town

St. Charles, MO, United States

9.7
$186
Hot Tub Gazebo, Game Room with Arcade, 2 King Beds, Fire Pit - Sleeps 8 Photo

Hot Tub Gazebo, Game Room with Arcade, 2 King Beds, Fire Pit - Sleeps 8

St. Charles, MO, United States

10.0
$264

Useful insights on St. Charles vacation rentals

Get a quick overview on price and accommodation trends for your visit in St. Charles

Average Length of Stay

4 days
On average, people stay for 4 days when lodging at vacation rentals in St. Charles. The average accommodation price for 4 days in St. Charles in the past week is $1,138.

When to book a vacation rental in St. Charles

Check out the information below to find the best deal on a vacation rental in St. Charles
Low SeasonDecembercheapest month to stay
High SeasonSeptembermost expensive time to stay
75%expected price decrease
38%expected price increase

Price

$59 - $379

Cheapest day of weekTuesdayis the cheapest day of the week to book
Highest day of weekThursdayis the most expensive day of the week to book
$179is the average per night cost for a vacation rental on this day
$771is the average per night cost for a vacation rental on this day

Information about staying in St. Charles

Read these important travel tips before booking a vacation rental in St. Charles

How long do people typically book vacation apartments for in St. Charles?

4 nights is the typical length of a St. Charles vacation rental booking.

When is the best time to book a vacation rental in St. Charles?

The cheapest month to rent a vacation apartment in St. Charles is usually April. The cost of your apartment or rental property can be around 29% cheaper in April vs. the high season.

What’s the best area of St. Charles to book a vacation rental in?

Downtown is the most popular area of St. Charles to book a rental apartment in.

How many operators does momondo search for hotels in St. Charles?

The number of operators available for hotels in St. Charles is 147 as of September 2026.

When did momondo last update prices for hotels in St. Charles?

Prices for hotels in St. Charles refresh daily.

Save money when you book vacation rentals with momondo

Best deals on hotels

Best deals on hotels

See deals from 3M+ hotels and accommodations in one place.

Free cancellation

Free cancellation

Use our filter to find stays with free cancellation.

Millions of reviews

Millions of reviews

Check ratings based on millions of real guest reviews.

Price Alerts

Price Alerts

Not ready to book? to track prices.

An easier way to manage your St. Charles trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
2 guests, 1 room
Thu 10/1
Fri 10/2
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your stay in St. Charles