Welcome to Holiday Inn Express & Suites Murphysboro-Carbondale, your perfect retreat in the heart of Southern Illinois. Located just seven miles from Southern Illinois University Carbondale, we offer a peaceful, authentic experience with easy access to campus events, alumni reunions, and nearby attractions. Discover the beauty of Shawnee National Forest, the Shawnee Hills Wine Trail, and Kinkaid Lake—all within minutes of the hotel. Explore the scenic Little Grand Canyon, go fishing or kayaking at Kinkaid Lake, or enjoy a visit to local vineyards and craft breweries. Our location is ideal for those seeking both adventure and relaxation in the great outdoors. Our hotel is conveniently located just off Highway 13, providing quick access to key destinations throughout Southern Illinois, including St. Joseph Memorial Hospital, Penn Aluminum, and Com-Pac International. Whether you're here for business or leisure, you'll find everything you need for a comfortable stay. Relax in our indoor heated pool, start your day with a complimentary Express Start Breakfast, and unwind in our well-appointed guest rooms. With modern amenities and warm hospitality, we’re committed to making your stay memorable. Whether visiting for university events, outdoor adventures, or a corporate trip, we ensure a welcoming, comfortable experience that exceeds your expectations.