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Cheap flights from Tampa to Santa Cruz de la Sierra from $385

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Tampa to Santa Cruz de la Sierra departing on 10/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Tampa to Santa Cruz de la Sierra

Cheap round-trip flights

Enter your travel dates to find the best prices.
Copa Airlines Logo
9:26 am - 3:44 amTPA  Tampa-VVI Santa Cruz de la Sierra Viru Viru Intl
17h 18m2 stops Houston George Bush Intcntl Panama City Tocumen Intl
Copa Airlines Logo
1:14 am - 5:37 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-TPA Tampa
17h 23m1 stop Panama City Tocumen Intl
$860Copa Airlines
Fri, Jan 1 - Thu, Jan 14
Copa Airlines Logo
4:51 am - 3:44 amTPA  Tampa-VVI Santa Cruz de la Sierra Viru Viru Intl
21h 53m1 stop Panama City Tocumen Intl
Copa Airlines Logo
1:14 am - 12:35 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-TPA Tampa
12h 21m1 stop Panama City Tocumen Intl
$972Copa Airlines
Thu, Dec 31 - Thu, Jan 14
Multiple Airlines Logo
2:30 pm - 8:25 pmTPA  Tampa-VVI Santa Cruz de la Sierra Viru Viru Intl
28h 55m2 stops Panama City Tocumen Intl Sao Paulo Guarulhos Intl
Multiple Airlines Logo
1:40 pm - 3:27 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-TPA Tampa
26h 47m2 stops Sao Paulo Guarulhos Intl Panama City Tocumen Intl
$1,002Multiple Airlines
Fri, Nov 20 - Sun, Nov 29
Multiple Airlines Logo
2:55 pm - 8:35 amTPA  Tampa-VVI Santa Cruz de la Sierra Viru Viru Intl
16h 40m2 stops Bogotá El Dorado La Paz El Alto Intl
Multiple Airlines Logo
5:35 am - 1:25 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-TPA Tampa
32h 50m3 stops La Paz El Alto Intl Cusco Velazco Astete Bogotá El Dorado
$1,035Multiple Airlines
Fri, Nov 20 - Sun, Nov 29
Multiple Airlines Logo
4:51 am - 10:46 pmTPA  Tampa-VVI Santa Cruz de la Sierra Viru Viru Intl
16h 55m1 stop Panama City Tocumen Intl
Multiple Airlines Logo
8:00 pm - 10:00 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-TPA Tampa
27h 00m2 stops Lima J Chavez Intl Panama City Tocumen Intl
$1,104Multiple Airlines
Thu, Dec 31 - Fri, Jan 15
Multiple Airlines Logo
2:55 pm - 2:35 amTPA  Tampa-VVI Santa Cruz de la Sierra Viru Viru Intl
10h 40m1 stop Bogotá El Dorado
Multiple Airlines Logo
3:40 am - 8:09 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-TPA Tampa
17h 29m2 stops Bogotá El Dorado Fort Lauderdale
$1,118Multiple Airlines
Fri, Nov 20 - Sat, Nov 28
Multiple Airlines Logo
7:12 pm - 10:46 pmTPA  Tampa-VVI Santa Cruz de la Sierra Viru Viru Intl
26h 34m2 stops Newark Panama City Tocumen Intl
Multiple Airlines Logo
1:14 am - 5:37 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-TPA Tampa
17h 23m2 stops Panama City Tocumen Intl Houston George Bush Intcntl
$1,199Multiple Airlines
Fri, Jan 1 - Thu, Jan 14
Copa Airlines Logo
2:30 pm - 3:37 amTPA  Tampa-VVI Santa Cruz de la Sierra Viru Viru Intl
12h 07m1 stop Panama City Tocumen Intl
Copa Airlines Logo
1:08 am - 12:40 pmVVI  Santa Cruz de la Sierra Viru Viru Intl-TPA Tampa
12h 32m1 stop Panama City Tocumen Intl
$1,286Copa Airlines
Fri, Nov 20 - Sat, Nov 28
United Airlines Logo
9:40 am - 3:42 amTPA  Tampa-VVI Santa Cruz de la Sierra Viru Viru Intl
17h 02m2 stops Houston George Bush Intcntl Panama City Tocumen Intl
United Airlines Logo
11:53 am - 10:43 amVVI  Santa Cruz de la Sierra Viru Viru Intl-TPA Tampa
23h 50m2 stops Panama City Tocumen Intl Houston George Bush Intcntl
$1,487United Airlines
Mon, Dec 7 - Wed, Jan 6
United Airlines Logo
7:15 am - 10:48 pmTPA  Tampa-VVI Santa Cruz de la Sierra Viru Viru Intl
38h 33m2 stops Houston George Bush Intcntl Panama City Tocumen Intl
United Airlines Logo
11:53 am - 10:43 amVVI  Santa Cruz de la Sierra Viru Viru Intl-TPA Tampa
23h 50m2 stops Panama City Tocumen Intl Houston George Bush Intcntl
$1,487United Airlines
Mon, Dec 7 - Thu, Jan 7

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United Airlines flights from Tampa to Santa Cruz de la Sierra

Our best United Airlines deals on Tampa to Santa Cruz de la Sierra flight tickets
United Airlines
Aug 14
TPA5:23 pmTampa
53h 17m
2 stops
VVI10:40 pmSanta Cruz de la Sierra Viru Viru Intl
Sep 10
VVI11:47 amSanta Cruz de la Sierra Viru Viru Intl
46h 54m
2 stops
TPA10:41 amTampa
$643
United Airlines
Nov 21
TPA7:15 pmTampa
31h 22m
2 stops
VVI3:37 amSanta Cruz de la Sierra Viru Viru Intl
Dec 21
VVI11:42 amSanta Cruz de la Sierra Viru Viru Intl
30h 45m
2 stops
TPA5:27 pmTampa
$826
United Airlines
Dec 7
TPA7:15 amTampa
38h 33m
2 stops
VVI10:48 pmSanta Cruz de la Sierra Viru Viru Intl
Jan 7
VVI11:53 amSanta Cruz de la Sierra Viru Viru Intl
23h 50m
2 stops
TPA10:43 amTampa
$1,487

Copa Airlines flights from Tampa to Santa Cruz de la Sierra

Our best Copa Airlines deals on Tampa to Santa Cruz de la Sierra flight tickets
Copa Airlines
Aug 14
TPA3:27 pmTampa
12h 08m
1 stop
VVI3:35 amSanta Cruz de la Sierra Viru Viru Intl
Sep 10
VVI11:47 amSanta Cruz de la Sierra Viru Viru Intl
11h 18m
1 stop
TPA11:05 pmTampa
$818
Copa Airlines
Aug 17
TPA3:27 pmTampa
12h 08m
1 stop
VVI3:35 amSanta Cruz de la Sierra Viru Viru Intl
Aug 24
VVI11:47 amSanta Cruz de la Sierra Viru Viru Intl
11h 18m
1 stop
TPA11:05 pmTampa
$841
Copa Airlines
Nov 21
TPA7:15 pmTampa
31h 22m
2 stops
VVI3:37 amSanta Cruz de la Sierra Viru Viru Intl
Dec 21
VVI11:42 amSanta Cruz de la Sierra Viru Viru Intl
30h 45m
1 stop
TPA5:27 pmTampa
$849

momondo Fare Finder

 
Customize your flight search to find flights from Tampa to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Tampa to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

TampaSanta Cruz de la Sierra

TPA Tampa - VVI Santa Cruz de la Sierra Viru Viru Intl

TPAVVI

Tampa

Fri 1/1

9:26 am-3:44 am

2 stops17h 18m

Santa Cruz de la Sierra Viru Viru Intl

Thu 1/14

1:14 am-5:37 pm

1 stop17h 23m

$860

TampaSanta Cruz de la Sierra

TPA Tampa - VVI Santa Cruz de la Sierra Viru Viru Intl

TPAVVI

Tampa

Thu 12/31

4:51 am-3:44 am

1 stop21h 53m

Santa Cruz de la Sierra Viru Viru Intl

Thu 1/14

1:14 am-12:35 pm

1 stop12h 21m

$972

TampaSanta Cruz de la Sierra

TPA Tampa - VVI Santa Cruz de la Sierra Viru Viru Intl

TPAVVI

Tampa

Fri 11/20

2:30 pm-8:25 pm

2 stops28h 55m

Santa Cruz de la Sierra Viru Viru Intl

Sun 11/29

1:40 pm-3:27 pm

2 stops26h 47m

$1,002

TampaSanta Cruz de la Sierra

TPA Tampa - VVI Santa Cruz de la Sierra Viru Viru Intl

TPAVVI

Tampa

Fri 11/20

2:55 pm-8:35 am

2 stops16h 40m

Santa Cruz de la Sierra Viru Viru Intl

Sun 11/29

5:35 am-1:25 pm

3 stops32h 50m

$1,035

TampaSanta Cruz de la Sierra

TPA Tampa - VVI Santa Cruz de la Sierra Viru Viru Intl

TPAVVI

Tampa

Thu 12/31

4:51 am-10:46 pm

1 stop16h 55m

Santa Cruz de la Sierra Viru Viru Intl

Fri 1/15

8:00 pm-10:00 pm

2 stops27h 00m

$1,104

TampaSanta Cruz de la Sierra

TPA Tampa - VVI Santa Cruz de la Sierra Viru Viru Intl

TPAVVI

Tampa

Fri 11/20

2:55 pm-2:35 am

1 stop10h 40m

Santa Cruz de la Sierra Viru Viru Intl

Sat 11/28

3:40 am-8:09 pm

2 stops17h 29m

$1,118

TampaSanta Cruz de la Sierra

TPA Tampa - VVI Santa Cruz de la Sierra Viru Viru Intl

TPAVVI

Tampa

Fri 1/1

7:12 pm-10:46 pm

2 stops26h 34m

Santa Cruz de la Sierra Viru Viru Intl

Thu 1/14

1:14 am-5:37 pm

2 stops17h 23m

$1,199
Quickest round-trip

TampaSanta Cruz de la Sierra

TPA Tampa - VVI Santa Cruz de la Sierra Viru Viru Intl

TPAVVI

Tampa

Fri 11/20

2:30 pm-3:37 am

1 stop12h 07m

Santa Cruz de la Sierra Viru Viru Intl

Sat 11/28

1:08 am-12:40 pm

1 stop12h 32m

$1,286

TampaSanta Cruz de la Sierra

TPA Tampa - VVI Santa Cruz de la Sierra Viru Viru Intl

TPAVVI

Tampa

Mon 12/7

9:40 am-3:42 am

2 stops17h 02m

Santa Cruz de la Sierra Viru Viru Intl

Wed 1/6

11:53 am-10:43 am

2 stops23h 50m

$1,487

TampaSanta Cruz de la Sierra

TPA Tampa - VVI Santa Cruz de la Sierra Viru Viru Intl

TPAVVI

Tampa

Mon 12/7

7:15 am-10:48 pm

2 stops38h 33m

Santa Cruz de la Sierra Viru Viru Intl

Thu 1/7

11:53 am-10:43 am

2 stops23h 50m

$1,487

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Tampa to Santa Cruz de la Sierra

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Tampa to Santa Cruz de la Sierra flights?

You could potentially save up to 34% on your flight if you consider stops on a Tampa to Santa Cruz de la Sierra flight.

When to book flights from Tampa to Santa Cruz de la Sierra

Are you open to changing your travel dates? Check out the ideal times to fly from Tampa to Santa Cruz de la Sierra according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Tampa to Santa Cruz de la Sierra (TPA to VVI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Tampa to Santa Cruz de la Sierra

Fastest flight time

12h 14m

Direct flights

None
The fastest flight from Tampa to Santa Cruz de la Sierra takes 12h 14m
There are no direct flights from Tampa to Santa Cruz de la Sierra. There are no popular flight routes from Tampa to Santa Cruz de la Sierra.
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Frequently asked questions about flying from Tampa to Santa Cruz de la Sierra

  • How far is Tampa to Santa Cruz de la Sierra Viru Viru Intl by plane?

    There are 3413.0 mi between Tampa and Santa Cruz de la Sierra Viru Viru Intl. A reasonable flight in good conditions will take 12h 14m.

  • When did momondo last update prices for flights from Tampa Airport to Santa Cruz de la Sierra Viru Viru Intl Airport?

    Prices for flights from Tampa Airport to Santa Cruz de la Sierra Viru Viru Intl Airport refresh daily.

  • How many operators does momondo search for flights from Tampa Airport to Santa Cruz de la Sierra Viru Viru Intl Airport?

  • How old do you have to be to fly from Tampa Airport to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Tampa Airport to Santa Cruz de la Sierra Viru Viru Intl Airport.

  • What documentation or ID do you need to fly to Santa Cruz de la Sierra Viru Viru Intl Airport?

    The necessary travel and health documents for your Santa Cruz de la Sierra Viru Viru Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Tampa to Santa Cruz de la Sierra?

Best airlines flying from Tampa to Santa Cruz de la Sierra

Compare and see reviews for airlines that fly from Tampa to Santa Cruz de la Sierra with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $529Free CancellationRating
7.6
1,563 reviews
Search Copa Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Tampa to Santa Cruz de la Sierra?

Finding the right flight to Santa Cruz de la Sierra from Tampa is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santa Cruz de la Sierra quick and easy, saving you time and money.

Can I find flights from Tampa to Santa Cruz de la Sierra with flexible booking policies on momondo?

Flights from Tampa to Santa Cruz de la Sierra with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Tampa to Santa Cruz de la Sierra?

momondo provides multiple filters to help you find the best flight to Santa Cruz de la Sierra from Tampa. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Tampa to Santa Cruz de la Sierra right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santa Cruz de la Sierra from Tampa. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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